MCID: BRR004
MIFTS: 22

Baroreflex Failure

Categories: Blood diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Baroreflex Failure

MalaCards integrated aliases for Baroreflex Failure:

Name: Baroreflex Failure 54 60

Characteristics:

Orphanet epidemiological data:

60
baroreflex failure
Inheritance: Not applicable;

Classifications:

Orphanet: 60  
Rare neurological diseases


External Ids:

ICD10 via Orphanet 35 G90.4
Orphanet 60 ORPHA443084

Summaries for Baroreflex Failure

NIH Rare Diseases : 54 Baroreflex failure is a rare disorder that causes fluctuations in blood pressure with episodes of severe hypertension (high blood pressure) and elevated heart rate in response to stress, exercise, and pain. Individuals may also have hypotension (low blood pressure) with normal or reduced heart rate during periods of rest. Symptoms of baroreflex failure may include headache, sweating, and a heart rate that does not respond to medications. The onset of baroreflex failure may be very abrupt or more gradual. In many cases, the cause of baroreflex failure is not known. However, baroreflex failure can result from surgery or radiation treatment for cancers of the neck, injury to the nerves involved in sensing blood pressure, or a degenerative neurologic disease. Treatment usually involves medications to control blood pressure and heart rate along with stress reduction techniques.

MalaCards based summary : Baroreflex Failure is related to nasopharyngeal carcinoma and pure autonomic failure. An important gene associated with Baroreflex Failure is ELP1 (Elongator Complex Protein 1). The drugs Norepinephrine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include heart and brain.

Wikipedia : 77 The baroreflex or baroreceptor reflex is one of the body''s homeostatic mechanisms that helps to... more...

Related Diseases for Baroreflex Failure

Diseases related to Baroreflex Failure via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)
# Related Disease Score Top Affiliating Genes
1 nasopharyngeal carcinoma 10.0
2 pure autonomic failure 10.0
3 multiple system atrophy 1 9.8
4 moebius syndrome 9.8
5 neuropathy, hereditary sensory and autonomic, type iii 9.8
6 neuroblastoma 9.8
7 paraganglioma 9.8
8 atrioventricular block 9.8
9 third-degree atrioventricular block 9.8
10 pulmonary edema 9.8
11 neuroma 9.8
12 cutis laxa 9.8
13 autoimmune autonomic ganglionopathy 9.8
14 syncope 9.8
15 dysautonomia 9.8
16 headache 9.8

Graphical network of the top 20 diseases related to Baroreflex Failure:



Diseases related to Baroreflex Failure

Symptoms & Phenotypes for Baroreflex Failure

Drugs & Therapeutics for Baroreflex Failure

Drugs for Baroreflex Failure (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Norepinephrine Approved Phase 2 51-41-2 439260
2
Dopamine Approved Phase 2 62-31-7, 51-61-6 681
3
Carbidopa Approved Phase 2 28860-95-9 34359
4 Dopamine Agents Phase 2
5 Antiparkinson Agents Phase 2
6 Neurotransmitter Agents Phase 2
7 Aromatic Amino Acid Decarboxylase Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Carbidopa for the Treatment of Excessive Blood Pressure Variability Recruiting NCT02553265 Phase 2 Carbidopa Low Dose;Carbidopa High Dose
2 Effects of Water and Glucose Drinks on Cardiovascular Function in Subjects With and Without Postprandial Hypotension Completed NCT02713412 Not Applicable
3 UK Registry for Baroreflex Activation Therapy Not yet recruiting NCT03730519 Not Applicable

Search NIH Clinical Center for Baroreflex Failure

Genetic Tests for Baroreflex Failure

Anatomical Context for Baroreflex Failure

MalaCards organs/tissues related to Baroreflex Failure:

42
Heart, Brain

Publications for Baroreflex Failure

Articles related to Baroreflex Failure:

(show all 43)
# Title Authors Year
1
Baroreflex failure and beat-to-beat blood pressure variation. ( 29880837 )
2018
2
Third-degree atrioventricular block followed by syncope, labile hypertension, and orthostatic hypotension in a patient with nasopharyngeal cancer: baroreflex failure. ( 30038845 )
2018
3
Diagnostic treatment dilemma: baroreflex failure or autoimmune autonomic ganglionopathy? ( 30151691 )
2018
4
Intraoperative baroreflex failure following lignocaine infiltration during unilateral radical neck dissection. ( 30104854 )
2018
5
Blood pressure oscillations in baroreflex failure. ( 27541037 )
2016
6
Baroreflex failure increases the risk of pulmonary edema in conscious rats with normal left ventricular function. ( 26589328 )
2016
7
Chewing-induced hypertension in afferent baroreflex failure: a sympathetic response? ( 26435473 )
2015
8
Dialysate temperature adjustment as an effective treatment for baroreflex failure syndrome in hemodialysis patient. ( 25231766 )
2014
9
Baroreflex failure, sympathetic storm, and cerebral vasospasm in fibulin-4 cutis laxa. ( 24733866 )
2014
10
Striking volume intolerance is induced by mimicking arterial baroreflex failure in normal left ventricular function. ( 24291683 )
2014
11
Baroreflex failure following radiotherapy for head and neck cancer: A case study. ( 24674125 )
2012
12
Moebius syndrome with baroreflex failure in an adolescent female. ( 27625823 )
2012
13
Afferent baroreflex failure and tako-tsubo cardiomyopathy. ( 21240537 )
2011
14
Pachymeningeal enhancement in baroreflex failure syndrome. ( 20660869 )
2010
15
Afferent baroreflex failure in familial dysautonomia. ( 21098405 )
2010
16
Components of arterial systolic pressure and RR-interval oscillation spectra in a case of baroreflex failure, a human open-loop model of vascular control. ( 19907435 )
2010
17
Baroreflex failure syndrome: a rare complication of bilateral carotid body tumor excision. ( 20935434 )
2010
18
Radiation-induced cranial neuropathies manifesting as baroreflex failure and progressive bulbar impairment. ( 19276789 )
2009
19
Paroxysmal hypertension due to baroreflex failure. ( 18322544 )
2008
20
Postlaryngectomy hypertensive crisis: a manifestation of perioperative acute baroreflex failure? ( 18063210 )
2007
21
Selective baroreflex failure complicated by unilateral neck irradiation. ( 16782217 )
2007
22
"Malignant" baroreflex failure after surgical resection of carotid body tumor. ( 17395286 )
2007
23
Mixed cranial nerve neuroma revealing itself as baroreflex failure. ( 16798103 )
2006
24
Headache in patients with baroreflex failure. ( 16866730 )
2006
25
Baroreflex failure: a rare complication of carotid paraganglioma surgery. ( 16652097 )
2006
26
Baroreflex failure. ( 15837841 )
2005
27
Baroreflex failure secondary to paraneoplastic encephalomyelitis in a 17 year old woman with neuroblastoma. ( 15489413 )
2004
28
Baroreflex failure: a neglected type of secondary hypertension. ( 15366697 )
2004
29
Effect of posture on blood and intraocular pressures in multiple system atrophy, pure autonomic failure, and baroreflex failure. ( 14597588 )
2003
30
Baroreflex failure as a late sequela of neck irradiation. ( 12782644 )
2003
31
Bionic technology revitalizes native baroreflex function in rats with baroreflex failure. ( 12163435 )
2002
32
Four faces of baroreflex failure: hypertensive crisis, volatile hypertension, orthostatic tachycardia, and malignant vagotonia. ( 12034659 )
2002
33
Brain stem stroke causing baroreflex failure and paroxysmal hypertension. ( 10926969 )
2000
34
Baroreflex failure syndrome after bilateral excision of carotid body tumors: an underestimated problem. ( 10753291 )
2000
35
Munchausen's syndrome presenting as baroreflex failure. ( 10979787 )
2000
36
Baroreflex failure following radiation therapy for nasopharyngeal carcinoma. ( 10638805 )
1999
37
Novel therapeutic strategy against central baroreflex failure: a bionic baroreflex system. ( 10411856 )
1999
38
Intraocular pressure and baroreflex failure. ( 9734892 )
1998
39
Malignant vagotonia due to selective baroreflex failure. ( 9369258 )
1997
40
Diagnosis and management of baroreflex failure. ( 11541912 )
1995
41
Baroreflex failure in a patient with central nervous system lesions involving the nucleus tractus solitarii. ( 8144218 )
1994
42
Baroreflex failure--a diagnostic challenge. ( 8413462 )
1993
43
The diagnosis and treatment of baroreflex failure. ( 8413455 )
1993

Variations for Baroreflex Failure

Expression for Baroreflex Failure

Search GEO for disease gene expression data for Baroreflex Failure.

Pathways for Baroreflex Failure

GO Terms for Baroreflex Failure

Sources for Baroreflex Failure

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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