MCID: BRR004
MIFTS: 21

Baroreflex Failure

Categories: Blood diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Baroreflex Failure

MalaCards integrated aliases for Baroreflex Failure:

Name: Baroreflex Failure 20 58

Characteristics:

Orphanet epidemiological data:

58
baroreflex failure
Inheritance: Not applicable;

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

ICD10 via Orphanet 33 G90.4
Orphanet 58 ORPHA443084

Summaries for Baroreflex Failure

GARD : 20 Baroreflex failure is a rare disorder that causes fluctuations in blood pressure with episodes of severe hypertension (high blood pressure) and elevated heart rate in response to stress, exercise, and pain. Individuals may also have hypotension (low blood pressure) with normal or reduced heart rate during periods of rest. Symptoms of baroreflex failure may include headache, sweating, and a heart rate that does not respond to medications. The onset of baroreflex failure may be very abrupt or more gradual. In many cases, the cause of baroreflex failure is not known. However, baroreflex failure can result from surgery or radiation treatment for cancers of the neck, injury to the nerves involved in sensing blood pressure, or a degenerative neurologic disease. Treatment usually involves medications to control blood pressure and heart rate along with stress reduction techniques.

MalaCards based summary : Baroreflex Failure is related to pure autonomic failure and syncope. An important gene associated with Baroreflex Failure is ELP1 (Elongator Acetyltransferase Complex Subunit 1). Affiliated tissues include heart, spinal cord and medulla oblongata.

Wikipedia : 73 The baroreflex or baroreceptor reflex is one of the body's homeostatic mechanisms that helps to maintain... more...

Related Diseases for Baroreflex Failure

Graphical network of the top 20 diseases related to Baroreflex Failure:



Diseases related to Baroreflex Failure

Symptoms & Phenotypes for Baroreflex Failure

Drugs & Therapeutics for Baroreflex Failure

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Investigation of the Efficacy and Safety of Baroreflex Activation Therapy in Patients With Refractory Hypertension and Those With Highly Variable Blood Pressure Due to Peripheral Baroreflex Failure Not yet recruiting NCT03730519

Search NIH Clinical Center for Baroreflex Failure

Genetic Tests for Baroreflex Failure

Anatomical Context for Baroreflex Failure

MalaCards organs/tissues related to Baroreflex Failure:

40
Heart, Spinal Cord, Medulla Oblongata, Adrenal Gland, Tonsil

Publications for Baroreflex Failure

Articles related to Baroreflex Failure:

(show top 50) (show all 127)
# Title Authors PMID Year
1
Do indices of baroreflex failure and peripheral noradrenergic deficiency predict the magnitude of orthostatic hypotension in Lewy body diseases? 61
33710459 2021
2
Afferent Baroreflex Dysfunction: Decreased or Excessive Signaling Results in Distinct Phenotypes. 61
32906172 2020
3
Carbidopa for Afferent Baroreflex Failure in Familial Dysautonomia: A Double-Blind Randomized Crossover Clinical Trial. 61
32654554 2020
4
Hyperperfusion Syndrome and Baroreflex Failure following Carotid Artery Angioplasty and Stenting for Symptomatic Radiation-Associated Carotid Artery Stenosis. 61
33505276 2020
5
Hyponatremia accompanying volatile hypertension caused by baroreflex failure after neck surgery: case report and literature review. 61
32371768 2020
6
Severe impaired blood pressure control caused by baroreflex failure as a late sequela of neck irradiation. 61
31764585 2020
7
Does glyceryl trinitrate cause central sympatholytic effects? Insights from a case of baroreflex failure. 61
31943625 2020
8
Chemoradiotherapy for Inoperable Carotid Body Leiomyosarcoma: A Case Report and Review of Literature. 61
33643904 2020
9
Blood Pressure Management in Afferent Baroreflex Failure: JACC Review Topic of the Week. 61
31806138 2019
10
Estimation of the baroreflex total loop gain by the power spectral analysis of continuous arterial pressure recordings. 61
30608176 2019
11
Diagnostic treatment dilemma: baroreflex failure or autoimmune autonomic ganglionopathy? 61
30151691 2018
12
PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex. 61
30361375 2018
13
Baroreflex failure and beat-to-beat blood pressure variation. 61
29880837 2018
14
Ambulatory blood pressure profiles in familial dysautonomia. 61
29435868 2018
15
[Differential Diagnostics of Vasovagal Fainting, Orthostatic Hypotension and Baroreflex Failure in a Patient With Syncope]. 61
29870329 2018
16
Intraoperative baroreflex failure following lignocaine infiltration during unilateral radical neck dissection. 61
30104854 2018
17
Third-degree atrioventricular block followed by syncope, labile hypertension, and orthostatic hypotension in a patient with nasopharyngeal cancer: baroreflex failure. 61
30038845 2018
18
Baroreceptor reflex failure: Review of the literature and the potential impact on patients with head and neck cancer. 61
28675547 2017
19
Management of Supine Hypertension Complicating Neurogenic Orthostatic Hypotension. 61
28702747 2017
20
Cerebral autoregulation and symptoms of orthostatic hypotension in familial dysautonomia. 61
27613312 2017
21
Cardiovascular sequel of neck irradiation in head and neck cancer patients. 61
28376642 2017
22
Overt and Subclinical Baroreflex Dysfunction After Bilateral Carotid Body Tumor Resection: Pathophysiology, Diagnosis, and Implications for Management. 61
28245992 2017
23
Blood pressure oscillations in baroreflex failure. 61
27541037 2016
24
Baroreflex dysfunction in sick newborns makes heart rate an unreliable surrogate for blood pressure changes. 61
26859365 2016
25
Mother-induced hypertension in familial dysautonomia. 61
26589199 2016
26
Volatile Hypertension Following Anterior Cervical Discectomy and Fusion: A Case Report. 61
29252718 2016
27
Baroreflex failure increases the risk of pulmonary edema in conscious rats with normal left ventricular function. 61
26589328 2016
28
Heart Failure as a Disruption of Dynamic Circulatory Homeostasis Mediated by the Brain. 61
26973279 2016
29
Chewing-induced hypertension in afferent baroreflex failure: a sympathetic response? 61
26435473 2015
30
Orthostatic Hypotension: Mechanisms, Causes, Management. 61
26174784 2015
31
Catecholamine excess: pseudopheochromocytoma and beyond. 61
25908471 2015
32
Current treatments in familial dysautonomia. 61
25323828 2014
33
Dialysate temperature adjustment as an effective treatment for baroreflex failure syndrome in hemodialysis patient. 61
25231766 2014
34
Quantitative indices of baroreflex-sympathoneural function: application to patients with chronic autonomic failure. 61
24706176 2014
35
Postprandial hypotension in de novo Parkinson's disease: a comparison with orthostatic hypotension. 61
24703893 2014
36
Baroreflex failure, sympathetic storm, and cerebral vasospasm in fibulin-4 cutis laxa. 61
24733866 2014
37
Hemorrhagic onset of hemangioblastoma located in the dorsal medulla oblongata presenting with tako-tsubo cardiomyopathy and neurogenic pulmonary edema: a case report. 61
24803905 2014
38
Striking volume intolerance is induced by mimicking arterial baroreflex failure in normal left ventricular function. 61
24291683 2014
39
Long term safety and efficacy of internal carotid artery adventitial stripping in carotid sinus syndrome. 61
25392145 2014
40
Supine-to-standing transcranial Doppler test in patients with multiple system atrophy. 61
23466059 2013
41
Long-term effects of neck irradiation on cardiovascular autonomic function: a study in nasopharyngeal carcinoma patients after radiotherapy. 61
23386577 2013
42
A novel approach to the design of an artificial bionic baroreflex. 61
24110562 2013
43
Recurrent syncope, orthostatic hypotension and volatile hypertension: think outside the box. 61
23882400 2013
44
Impaired baroreflex function in mice overexpressing alpha-synuclein. 61
23888153 2013
45
Moebius syndrome with baroreflex failure in an adolescent female. 61
27625823 2012
46
Baroreflex failure following radiotherapy for head and neck cancer: A case study. 61
24674125 2012
47
Carotid body tumors and our surgical approaches. 61
23730577 2012
48
Cardiovascular dysautonomia in Parkinson disease: from pathophysiology to pathogenesis. 61
22094370 2012
49
Postoperative hypertension following radical neck dissection. 61
22345960 2012
50
Autonomic dysfunction in PD: a window to early detection? 61
21529844 2011

Variations for Baroreflex Failure

Expression for Baroreflex Failure

Search GEO for disease gene expression data for Baroreflex Failure.

Pathways for Baroreflex Failure

GO Terms for Baroreflex Failure

Sources for Baroreflex Failure

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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