MCID: BRR004
MIFTS: 25

Baroreflex Failure

Categories: Blood diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Baroreflex Failure

MalaCards integrated aliases for Baroreflex Failure:

Name: Baroreflex Failure 53 59

Characteristics:

Orphanet epidemiological data:

59
baroreflex failure
Inheritance: Not applicable;

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

ICD10 via Orphanet 34 G90.4
Orphanet 59 ORPHA443084

Summaries for Baroreflex Failure

NIH Rare Diseases : 53 Baroreflex failure is a rare disorder that causes fluctuations in blood pressure with episodes of severe hypertension (high blood pressure) and elevated heart rate in response to stress, exercise, and pain. Individuals may also have hypotension (low blood pressure) with normal or reduced heart rate during periods of rest. Symptoms of baroreflex failure may include headache, sweating, and a heart rate that does not respond to medications. The onset of baroreflex failure may be very abrupt or more gradual. In many cases, the cause of baroreflex failure is not known. However, baroreflex failure can result from surgery or radiation treatment for cancers of the neck, injury to the nerves involved in sensing blood pressure, or a degenerative neurologic disease. Treatment usually involves medications to control blood pressure and heart rate along with stress reduction techniques.

MalaCards based summary : Baroreflex Failure is related to pure autonomic failure and syncope. An important gene associated with Baroreflex Failure is ELP1 (Elongator Complex Protein 1). The drugs Dopamine and Levodopa have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and testes.

Wikipedia : 75 The baroreflex or baroreceptor reflex is one of the body's homeostatic mechanisms that helps to maintain... more...

Related Diseases for Baroreflex Failure

Graphical network of the top 20 diseases related to Baroreflex Failure:



Diseases related to Baroreflex Failure

Symptoms & Phenotypes for Baroreflex Failure

Drugs & Therapeutics for Baroreflex Failure

Drugs for Baroreflex Failure (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
2
Levodopa Approved Phase 3 59-92-7 6047
3
Metoclopramide Approved, Investigational Phase 3 364-62-5 4168
4
Methyldopa Approved Phase 3 555-30-6 38853
5
Carbidopa Approved Phase 3 28860-95-9 34359
6
Droxidopa Approved, Investigational Phase 3 23651-95-8 443940
7 Neurotransmitter Agents Phase 3
8 Dopamine Agents Phase 3
9 Adrenergic alpha-2 Receptor Agonists Phase 3
10 Adrenergic Agonists Phase 3
11 Gastrointestinal Agents Phase 3
12 alpha-methyltyrosine Phase 3
13 Antiemetics Phase 3
14 Adrenergic alpha-Agonists Phase 3
15 Neurotransmitter Uptake Inhibitors Phase 3
16 Peripheral Nervous System Agents Phase 3
17 Antiparkinson Agents Phase 3
18 Adrenergic Agents Phase 3
19 Antihypertensive Agents Phase 3
20 Sympatholytics Phase 3
21 Aromatic Amino Acid Decarboxylase Inhibitors Phase 3
22 Atomoxetine Hydrochloride Phase 3
23 Dopamine Antagonists Phase 3
24 Dopamine D2 Receptor Antagonists Phase 3
25 Autonomic Agents Phase 3
26
Norepinephrine Approved Phase 2 51-41-2 439260
27 Sympathomimetics Phase 1, Phase 2
28 Vasoconstrictor Agents Phase 1, Phase 2
29
Racepinephrine Approved 329-65-7 838
30
Epinephrine Approved, Vet_approved 51-43-4 5816
31 Epinephryl borate

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Hypotensive Patients Having a Unique Pattern of Autonomic Symptoms Enrolling by invitation NCT00581477 Phase 3 droxidopa;placebo;alpha-methyldopa;carbidopa;metyrosine;levodopa;atomoxetine;metoclopramide
2 Safety and Efficacy of Intravenous Norepinephrine for Orthostatic Hypotension Completed NCT01285908 Phase 1, Phase 2 Intravenous Norepinephrine Infusion
3 Carbidopa in Familial Dysautonomia: Phase-II Study, Investigational New Drug (IND) 117435, Date: 01/07/13 Recruiting NCT02553265 Phase 2 Carbidopa Low Dose;Carbidopa High Dose
4 Clinical Laboratory Evaluation of Chronic Orthostatic Intolerance Completed NCT00069693
5 BAROSTIM THERAPY™ In Resistant Hypertension: A Post-Market Registry With the CE-Marked BAROSTIM NEO™ System Recruiting NCT02880631
6 BAROSTIM THERAPY ™ in Heart Failure With Preserved Ejection Fraction: A Post-Market Registry With the CE-Marked BAROSTIM NEO™ System Recruiting NCT02876042
7 BAROSTIM THERAPY™ in Heart Failure With Reduced Ejection Fraction: A Post-Market Registry With the CE-Marked BAROSTIM NEO™ System Recruiting NCT02880618
8 Investigation of the Efficacy and Safety of Baroreflex Activation Therapy in Patients With Refractory Hypertension and Those With Highly Variable Blood Pressure Due to Peripheral Baroreflex Failure Not yet recruiting NCT03730519

Search NIH Clinical Center for Baroreflex Failure

Genetic Tests for Baroreflex Failure

Anatomical Context for Baroreflex Failure

MalaCards organs/tissues related to Baroreflex Failure:

41
Heart, Brain, Testes, Spinal Cord, Medulla Oblongata

Publications for Baroreflex Failure

Articles related to Baroreflex Failure:

(show top 50) (show all 118)
# Title Authors PMID Year
1
Estimation of the baroreflex total loop gain by the power spectral analysis of continuous arterial pressure recordings. 38
30608176 2019
2
Diagnostic treatment dilemma: baroreflex failure or autoimmune autonomic ganglionopathy? 38
30151691 2018
3
PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex. 38
30361375 2018
4
Baroreflex failure and beat-to-beat blood pressure variation. 38
29880837 2018
5
Ambulatory blood pressure profiles in familial dysautonomia. 38
29435868 2018
6
[Differential Diagnostics of Vasovagal Fainting, Orthostatic Hypotension and Baroreflex Failure in a Patient With Syncope]. 38
29870329 2018
7
Intraoperative baroreflex failure following lignocaine infiltration during unilateral radical neck dissection. 38
30104854 2018
8
Third-degree atrioventricular block followed by syncope, labile hypertension, and orthostatic hypotension in a patient with nasopharyngeal cancer: baroreflex failure. 38
30038845 2018
9
Baroreceptor reflex failure: Review of the literature and the potential impact on patients with head and neck cancer. 38
28675547 2017
10
Management of Supine Hypertension Complicating Neurogenic Orthostatic Hypotension. 38
28702747 2017
11
Cerebral autoregulation and symptoms of orthostatic hypotension in familial dysautonomia. 38
27613312 2017
12
Cardiovascular sequel of neck irradiation in head and neck cancer patients. 38
28376642 2017
13
Overt and Subclinical Baroreflex Dysfunction After Bilateral Carotid Body Tumor Resection: Pathophysiology, Diagnosis, and Implications for Management. 38
28245992 2017
14
Blood pressure oscillations in baroreflex failure. 38
27541037 2016
15
Baroreflex dysfunction in sick newborns makes heart rate an unreliable surrogate for blood pressure changes. 38
26859365 2016
16
Mother-induced hypertension in familial dysautonomia. 38
26589199 2016
17
Volatile Hypertension Following Anterior Cervical Discectomy and Fusion: A Case Report. 38
29252718 2016
18
Baroreflex failure increases the risk of pulmonary edema in conscious rats with normal left ventricular function. 38
26589328 2016
19
Heart Failure as a Disruption of Dynamic Circulatory Homeostasis Mediated by the Brain. 38
26973279 2016
20
Chewing-induced hypertension in afferent baroreflex failure: a sympathetic response? 38
26435473 2015
21
Orthostatic Hypotension: Mechanisms, Causes, Management. 38
26174784 2015
22
Catecholamine excess: pseudopheochromocytoma and beyond. 38
25908471 2015
23
Current treatments in familial dysautonomia. 38
25323828 2014
24
Dialysate temperature adjustment as an effective treatment for baroreflex failure syndrome in hemodialysis patient. 38
25231766 2014
25
Quantitative indices of baroreflex-sympathoneural function: application to patients with chronic autonomic failure. 38
24706176 2014
26
Postprandial hypotension in de novo Parkinson's disease: a comparison with orthostatic hypotension. 38
24703893 2014
27
Baroreflex failure, sympathetic storm, and cerebral vasospasm in fibulin-4 cutis laxa. 38
24733866 2014
28
Hemorrhagic onset of hemangioblastoma located in the dorsal medulla oblongata presenting with tako-tsubo cardiomyopathy and neurogenic pulmonary edema: a case report. 38
24803905 2014
29
Striking volume intolerance is induced by mimicking arterial baroreflex failure in normal left ventricular function. 38
24291683 2014
30
Long term safety and efficacy of internal carotid artery adventitial stripping in carotid sinus syndrome. 38
25392145 2014
31
Supine-to-standing transcranial Doppler test in patients with multiple system atrophy. 38
23466059 2013
32
Long-term effects of neck irradiation on cardiovascular autonomic function: a study in nasopharyngeal carcinoma patients after radiotherapy. 38
23386577 2013
33
Impaired baroreflex function in mice overexpressing alpha-synuclein. 38
23888153 2013
34
A novel approach to the design of an artificial bionic baroreflex. 38
24110562 2013
35
Recurrent syncope, orthostatic hypotension and volatile hypertension: think outside the box. 38
23882400 2013
36
Moebius syndrome with baroreflex failure in an adolescent female. 38
27625823 2012
37
Baroreflex failure following radiotherapy for head and neck cancer: A case study. 38
24674125 2012
38
Cardiovascular dysautonomia in Parkinson disease: from pathophysiology to pathogenesis. 38
22094370 2012
39
Carotid body tumors and our surgical approaches. 38
23730577 2012
40
Postoperative hypertension following radical neck dissection. 38
22345960 2012
41
Mechanisms of orthostatic hypotension and supine hypertension in Parkinson disease. 38
21762927 2011
42
Autonomic dysfunction in PD: a window to early detection? 38
21529844 2011
43
Afferent baroreflex failure and tako-tsubo cardiomyopathy. 38
21240537 2011
44
Tako-tsubo cardiomyopathy in a patient with bilateral lesions in the dorsal medulla. 38
20963467 2011
45
What Happens before Syncope? Study of the Time Frame Preceding Vasovagal Syncope. 38
22347649 2011
46
Afferent baroreflex failure in familial dysautonomia. 38
21098405 2010
47
Pachymeningeal enhancement in baroreflex failure syndrome. 38
20660869 2010
48
Baroreflex failure syndrome: a rare complication of bilateral carotid body tumor excision. 38
20935434 2010
49
Components of arterial systolic pressure and RR-interval oscillation spectra in a case of baroreflex failure, a human open-loop model of vascular control. 38
19907435 2010
50
Cardiac ectopy in chronic autonomic failure. 38
20012145 2010

Variations for Baroreflex Failure

Expression for Baroreflex Failure

Search GEO for disease gene expression data for Baroreflex Failure.

Pathways for Baroreflex Failure

GO Terms for Baroreflex Failure

Sources for Baroreflex Failure

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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