MCID: BRR002
MIFTS: 35

Barrett's Adenocarcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Barrett's Adenocarcinoma

MalaCards integrated aliases for Barrett's Adenocarcinoma:

Name: Barrett's Adenocarcinoma 12 15 71
Barrett Adenocarcinoma 12 17
Adenocarcinoma Arising in Barrett's Mucosa 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7941
NCIt 49 C7027
UMLS 71 C1332460

Summaries for Barrett's Adenocarcinoma

MalaCards based summary : Barrett's Adenocarcinoma, also known as barrett adenocarcinoma, is related to esophagitis and barrett esophagus. An important gene associated with Barrett's Adenocarcinoma is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Cytochrome P450 - arranged by substrate type and Drug metabolism - cytochrome P450. Affiliated tissues include breast, heart and lung, and related phenotypes are homeostasis/metabolism and liver/biliary system

Related Diseases for Barrett's Adenocarcinoma

Diseases related to Barrett's Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)
# Related Disease Score Top Affiliating Genes
1 esophagitis 30.7 TP53 PTGS2 CDKN2A
2 barrett esophagus 30.3 TP53 PTGS2 GSTP1 FHIT ERBB2 CDKN2A
3 squamous cell carcinoma 29.5 TP53 PTGS2 GSTP1 FHIT ERBB2 CDKN2A
4 gastric adenocarcinoma 29.2 TP53 PTGS2 GSTP1 FHIT ERBB2 CDKN2A
5 esophageal cancer 28.7 TP53 RAD51 PTGS2 OGG1 GSTP1 FHIT
6 adenocarcinoma 10.9
7 gastric papillary adenocarcinoma 10.5 TP53 ERBB2
8 breast squamous cell carcinoma 10.5 TP53 ERBB2
9 apocrine adenosis of breast 10.5 TP53 ERBB2
10 parotid gland cancer 10.5 TP53 ERBB2
11 comedo carcinoma 10.5 TP53 ERBB2
12 parotid gland adenoid cystic carcinoma 10.5 ERBB2 CDKN2A
13 vulvar intraepithelial neoplasia 10.4 TP53 CDKN2A
14 pleomorphic adenoma carcinoma 10.4 TP53 ERBB2
15 ovarian seromucinous carcinoma 10.4 TP53 CDKN2A
16 bowenoid papulosis 10.4 PTGS2 CDKN2A
17 gastroesophageal reflux 10.4
18 esophagus verrucous carcinoma 10.4 TP53 CDKN2A
19 breast malignant phyllodes tumor 10.4 TP53 ERBB2
20 spitz nevus 10.4 TP53 CDKN2A
21 type 1 diabetes mellitus 3 10.4 GSTM5 GSTM2
22 large intestine adenocarcinoma 10.4 TP53 ERBB2
23 vulvar disease 10.3 TP53 ERBB2 CDKN2A
24 peritoneum cancer 10.3 TP53 ERBB2 CDKN2A
25 chronic cervicitis 10.3 TP53 CDKN2A
26 breast papillomatosis 10.3 ERBB2 CDKN2A
27 tonsil cancer 10.3 TP53 ERBB2 CDKN2A
28 uterine corpus cancer 10.3 TP53 ERBB2 CDKN2A
29 vulva cancer 10.3 TP53 ERBB2 CDKN2A
30 ovarian cystadenocarcinoma 10.3 TP53 ERBB2 CDKN2A
31 oropharynx cancer 10.3 TP53 ERBB2 CDKN2A
32 childhood medulloblastoma 10.3 TP53 ERBB2 CDKN2A
33 pancreatic ductal carcinoma 10.3 TP53 ERBB2 CDKN2A
34 actinic keratosis 10.3 TP53 PTGS2 CDKN2A
35 mucinous adenocarcinoma 10.3 TP53 ERBB2 CDKN2A
36 endometrial adenocarcinoma 10.3 TP53 ERBB2 CDKN2A
37 in situ carcinoma 10.3 TP53 ERBB2 CDKN2A
38 ovary adenocarcinoma 10.3 TP53 ERBB2 CDKN2A
39 pleomorphic adenoma 10.2 TP53 ERBB2 CDKN2A
40 oral leukoplakia 10.2 TP53 CDKN2A
41 pre-malignant neoplasm 10.2 TP53 PTGS2 ERBB2 CDKN2A
42 cervical adenocarcinoma 10.2 TP53 PTGS2 ERBB2 CDKN2A
43 skin melanoma 10.2 TP53 PTGS2 ERBB2 CDKN2A
44 ductal carcinoma in situ 10.2 TP53 PTGS2 ERBB2 CDKN2A
45 colorectal adenoma 10.2 TP53 PTGS2 GSTP1 CDKN2A
46 thyroid lymphoma 10.2 TP53 CDKN2A
47 colorectal adenocarcinoma 10.2 TP53 PTGS2 ERBB2 CDKN2A
48 uterine carcinosarcoma 10.2 TP53 PTGS2 ERBB2 CDKN2A
49 peptic esophagitis 10.2
50 dysphagia 10.2

Graphical network of the top 20 diseases related to Barrett's Adenocarcinoma:



Diseases related to Barrett's Adenocarcinoma

Symptoms & Phenotypes for Barrett's Adenocarcinoma

MGI Mouse Phenotypes related to Barrett's Adenocarcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.97 CDKN2A ERBB2 FHIT GPX3 GSTM5 GSTO1
2 liver/biliary system MP:0005370 9.5 CDKN2A GSTZ1 OGG1 PTGS2 SOCS1 SOCS3
3 neoplasm MP:0002006 9.17 CDKN2A ERBB2 FHIT OGG1 PTGS2 SOCS1

Drugs & Therapeutics for Barrett's Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Barrett's Adenocarcinoma

Genetic Tests for Barrett's Adenocarcinoma

Anatomical Context for Barrett's Adenocarcinoma

MalaCards organs/tissues related to Barrett's Adenocarcinoma:

40
Breast, Heart, Lung, Skin, Ovary, Cervix, Lymph Node

Publications for Barrett's Adenocarcinoma

Articles related to Barrett's Adenocarcinoma:

(show top 50) (show all 297)
# Title Authors PMID Year
1
Barrett's adenocarcinoma with esophageal varices successfully treated by endoscopic submucosal dissection with direct varices coagulation. 61
31559540 2019
2
Time trends in the incidence of esophageal adenocarcinoma, gastric adenocarcinoma, and superficial esophagogastric junction adenocarcinoma. 61
30927083 2019
3
A Primary Barrett's Adenocarcinoma with a Squamous Cell Carcinoma Component. 61
31118396 2019
4
Strong Intra-Esophageal Reflux May Contribute to the Development of Barrett's Adenocarcinoma and Affect the Localization. 61
31412336 2019
5
Host factors influence Barrett's carcinogenesis: findings from a mouse gastroduodenal reflux model. 61
30790117 2019
6
Endoscopic Treatment of Early Barrett's Adenocarcinoma and Dysplasia: Focus on Submucosal Cancer. 61
30176662 2019
7
Buried Barrett's Adenocarcinoma Clearly Demonstrated with Acetic Acid Chromoendoscopy. 61
30166635 2018
8
Reduced ╬▒GlcNAc glycosylation on gastric gland mucin is a biomarker of malignant potential for gastric cancer, Barrett's adenocarcinoma, and pancreatic cancer. 61
29658052 2018
9
Genome-Wide Analysis of Barrett's Adenocarcinoma. A First Step Towards Identifying Patients at Risk and Developing Therapeutic Paths. 61
29223109 2018
10
Treatment of long-segment Barrett's adenocarcinoma by complete circular endoscopic submucosal dissection: a case report. 61
29351773 2018
11
Endoscopic Submucosal Dissection for Adenocarcinomas of the Esophagogastric Junction. 61
29393168 2018
12
Association between circulating levels of sex steroid hormones and esophageal adenocarcinoma in the FINBAR Study. 61
29342161 2018
13
Minimally invasive esophagectomy for Barrett's adenocarcinoma. 61
30505964 2018
14
Tumor location is a risk factor for lymph node metastasis in superficial Barrett's adenocarcinoma. 61
28924592 2017
15
Dietary inflammatory index and risk of reflux oesophagitis, Barrett's oesophagus and oesophageal adenocarcinoma: a population-based case-control study. 61
28571591 2017
16
Different time trend and management of esophagogastric junction adenocarcinoma in three Asian countries. 61
28425657 2017
17
Sex steroid hormones in relation to Barrett's esophagus: an analysis of the FINBAR Study. 61
28241109 2017
18
Laser Imaging Facilitates Early Detection of Synchronous Adenocarcinomas in Patients with Barrett's Esophagus. 61
27157857 2017
19
[Gastrointestinal Diseases in the Era without Helicobacter pylori infection. Topics: VII. Barrett Adenocarcinoma]. 61
30179407 2017
20
[Treatment Strategy for Esophagogastric Junction Carcinoma;Highly Controversial Topic in the Upper Gastrointestinal Malignancy]. 61
28174399 2017
21
Impact of RAD51C-mediated Homologous Recombination on Genomic Integrity in Barrett's Adenocarcinoma Cells. 61
29399538 2017
22
[Pathogenetic aspects in precursor lesions of gastrointestinal tumors]. 61
27638535 2016
23
Her-2 Expression in Gastroesophageal Intestinal Metaplasia, Dysplasia, and Adenocarcinoma. 61
26186253 2016
24
[Endoscopic therapy of esophageal diseases]. 61
27307161 2016
25
A case of simultaneous esophageal squamous cell carcinoma and Barrett's adenocarcinoma. 61
27220657 2016
26
Case of Barrett's adenocarcinoma with marked endoscopic morphological changes in Barrett's esophagus over a long follow-up period of 15 years. 61
26946036 2016
27
Feasibility of optical coherence tomography for the evaluation of Barrett's mucosa buried underneath esophageal squamous epithelium. 61
26583560 2016
28
Role of nitric oxide in the pathogenesis of Barrett's-associated carcinogenesis. 61
26909236 2016
29
Proton Pump Inhibitors Display Antitumor Effects in Barrett's Adenocarcinoma Cells. 61
27932981 2016
30
Endoscopic Treatment of Early Barrett's Neoplasia: Expanding Indications, New Challenges. 61
27573769 2016
31
Submucosal invasion and risk of lymph node invasion in early Barrett's cancer: potential impact of different classification systems on patient management. 61
26668743 2015
32
[A Case of Synchronous Multiple Esophageal Cancers Composed of Squamous Cell Carcinoma and Barrett's Adenocarcinoma]. 61
26805207 2015
33
[Barrett's esophagus: its diagnosis and management in Japan]. 61
26165069 2015
34
Useful strategies to prevent severe stricture after endoscopic submucosal dissection for superficial esophageal neoplasm. 61
26109798 2015
35
Single center experience of endoscopic submucosal dissection (ESD) in early Barrett's adenocarcinoma. 61
25294533 2015
36
A cross sectional study of p504s, CD133, and Twist expression in the esophageal metaplasia dysplasia adenocarcinoma sequence. 61
24612412 2015
37
Strategy for prevention of cancers of the esophagus. 61
25266020 2014
38
Ischemic heart disease, factor predisposing to Barrett's adenocarcinoma: A case control study. 61
25133047 2014
39
Clinical outcomes of endoscopic submucosal dissection for superficial Barrett's adenocarcinoma. 61
24565073 2014
40
Multi-colour FISH in oesophageal adenocarcinoma-predictors of prognosis independent of stage and grade. 61
24853183 2014
41
Barrett's esophagus in the patients with familial adenomatous polyposis. 61
23771323 2014
42
Endoscopic diagnosis of early Barrett's neoplasia: perspectives for advanced endoscopic technology. 61
24754238 2014
43
The evil lies below the surface: Subsquamous tumor extension in Barrett's adenocarcinoma. 61
26134612 2014
44
Targeting homologous recombination and telomerase in Barrett's adenocarcinoma: impact on telomere maintenance, genomic instability and tumor growth. 61
23604115 2014
45
Reduced expression of ╬▒GlcNAc in Barrett's oesophagus adjacent to Barrett's adenocarcinoma--a possible biomarker to predict the malignant potential of Barrett's oesophagus. 61
24117499 2014
46
Clinical Efficacy of Endoscopic Submucosal Dissection for Adenocarcinomas of the Esophagogastric Junction. 61
26134607 2014
47
[Challenges and limits for endoscopic resection of oesophageal and oesophagogastric cancer]. 61
24585194 2014
48
Volumetric laser endomicroscopy detects subsquamous Barrett's adenocarcinoma. 61
24496431 2014
49
Role of proton pump inhibitor on esophageal carcinogenesis and pancreatic acinar cell metaplasia development: an experimental in vivo study. 61
25415190 2014
50
Different histological status of gastritis in superficial adenocarcinoma of the esophagogastric junction. 61
24220802 2014

Variations for Barrett's Adenocarcinoma

Copy number variations for Barrett's Adenocarcinoma from CNVD:

7 (show top 50) (show all 60)
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 39411 10 114900000 119100000 Gain ABLIM1 Barrett''s adenocarcinoma
2 39412 10 114900000 119100000 Gain AFAP1L2 Barrett''s adenocarcinoma
3 42467 10 34500000 38800000 Gain CCNY Barrett''s adenocarcinoma
4 42468 10 34500000 38800000 Gain CUL2 Barrett''s adenocarcinoma
5 65755 12 21200000 26300000 Gain SSPN Barrett''s adenocarcinoma
6 66184 12 26300000 27700000 Gain ARNTL2 Barrett''s adenocarcinoma
7 66185 12 26300000 27700000 Gain TM7SF3 Barrett''s adenocarcinoma
8 73111 12 91200000 94800000 Gain KRT19P2 Barrett''s adenocarcinoma
9 74577 13 109100000 114142980 Gain Barrett''s adenocarcinoma
10 75797 13 24400000 26700000 Gain Barrett''s adenocarcinoma
11 79796 13 77800000 86500000 Gain SOX1 Barrett''s adenocarcinoma
12 81034 14 100400000 102200000 Gain SLC25A29 Barrett''s adenocarcinoma
13 88798 14 95400000 100400000 Gain TCL1A Barrett''s adenocarcinoma
14 88799 14 95400000 100400000 Gain TCL1B Barrett''s adenocarcinoma
15 107009 17 11200000 15900000 Loss RICH2 Barrett''s adenocarcinoma
16 114436 17 47600000 54900000 Gain CUEDC1 Barrett''s adenocarcinoma
17 115246 17 55600000 58400000 Gain LRRC37A3 Barrett''s adenocarcinoma
18 116543 17 6800000 11200000 Loss MYH13 Barrett''s adenocarcinoma
19 116544 17 6800000 11200000 Loss TP53 Barrett''s adenocarcinoma
20 122243 18 54400000 57100000 Loss Barrett''s adenocarcinoma
21 125938 19 16100000 19800000 Gain AP1M1 Barrett''s adenocarcinoma
22 127254 19 30200000 37100000 Gain ZNF536 Barrett''s adenocarcinoma
23 134771 2 106700000 108600000 Gain GCC2 Barrett''s adenocarcinoma
24 141056 2 205600000 209100000 Gain Barrett''s adenocarcinoma
25 144816 2 29800000 31900000 Gain ALK Barrett''s adenocarcinoma
26 151523 20 22300000 25700000 Gain SSTR4 Barrett''s adenocarcinoma
27 151524 20 22300000 25700000 Loss CST4 Barrett''s adenocarcinoma
28 152533 20 31500000 33900000 Gain CEP250 Barrett''s adenocarcinoma
29 154854 20 49200000 54400000 Gain CBLN4 Barrett''s adenocarcinoma
30 170891 3 161200000 169200000 Gain BCHE Barrett''s adenocarcinoma
31 172565 3 184200000 186000000 Gain MAGEF1 Barrett''s adenocarcinoma
32 172566 3 184200000 186000000 Gain MUC13 Barrett''s adenocarcinoma
33 172567 3 184200000 186000000 Gain VPS8 Barrett''s adenocarcinoma
34 177566 3 58500000 63700000 Loss Barrett''s adenocarcinoma
35 196847 5 172200000 176500000 Gain MSX2 Barrett''s adenocarcinoma
36 203652 6 1 2300000 Gain Barrett''s adenocarcinoma
37 204555 6 11200000 13500000 Gain PHACTR1 Barrett''s adenocarcinoma
38 205460 6 127300000 130400000 Gain C6orf190 Barrett''s adenocarcinoma
39 205461 6 127300000 130400000 Gain PTPRK Barrett''s adenocarcinoma
40 212308 6 36800000 40600000 Gain DNAH8 Barrett''s adenocarcinoma
41 219021 7 120900000 123600000 Loss SLC13A1 Barrett''s adenocarcinoma
42 219022 7 120900000 123600000 Loss TAS2R16 Barrett''s adenocarcinoma
43 225150 7 43300000 46600000 Gain RAMP3 Barrett''s adenocarcinoma
44 225833 7 50900000 53900000 Gain Barrett''s adenocarcinoma
45 227260 7 66100000 71800000 Gain CALN1 Barrett''s adenocarcinoma
46 227261 7 66100000 71800000 Gain WBSCR17 Barrett''s adenocarcinoma
47 227796 7 7200000 13300000 Gain ICA1 Barrett''s adenocarcinoma
48 231014 8 101600000 106100000 Gain ANKRD46 Barrett''s adenocarcinoma
49 231021 8 101600000 106100000 Gain RNF19 Barrett''s adenocarcinoma
50 232059 8 110600000 112200000 Gain PKHD1L1 Barrett''s adenocarcinoma

Expression for Barrett's Adenocarcinoma

Search GEO for disease gene expression data for Barrett's Adenocarcinoma.

Pathways for Barrett's Adenocarcinoma

Pathways related to Barrett's Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.04 GSTZ1 GSTP1 GSTO2 GSTO1 GSTM5 GSTM3
2
Show member pathways
12.68 PTGS2 GSTP1 GSTO2 GSTO1 GSTM5 GSTM3
3
Show member pathways
12.67 TP53 RAD51 GSTP1 ERBB2 CDKN2A
4
Show member pathways
12.64 TP53 GSTP1 GSTO2 GSTO1 GSTM5 GSTM3
5 12.42 TP53 RAD51 PTGS2 GSTP1 GSTO2 GSTO1
6 12.37 TP53 SOCS1 PTGS2 ERBB2 CDKN2A
7
Show member pathways
12.07 GSTZ1 GSTP1 GSTO2 GSTO1 GSTM5 GSTM3
8 11.94 TP53 GSTP1 GSTO2 GSTO1 GSTM5 GSTM3
9 11.93 GSTP1 GSTM5 GSTM3 GSTM2 GPX3
10 11.81 TP53 SOCS3 SOCS1 PTGS2
11 11.65 TP53 PTGS2 FHIT
12 11.53 TP53 ERBB2 CDKN2A
13 11.14 TP53 GSTP1 GSTO2 GSTO1 GSTM5 GSTM3
14 10.71 PTGS2 GSTP1

GO Terms for Barrett's Adenocarcinoma

Cellular components related to Barrett's Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 10 TP53 SOCS1 RAD51 PTGS2 GSTZ1 GSTP1
2 cytosol GO:0005829 9.5 TP53 TAGLN2 SOCS3 SOCS1 RAD51 GSTZ1
3 intercellular bridge GO:0045171 9.13 GSTM5 GSTM3 GSTM2

Biological processes related to Barrett's Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.97 TP53 SOCS3 PTGS2 OGG1 GSTP1
2 cytokine-mediated signaling pathway GO:0019221 9.88 TP53 SOCS3 SOCS1 PTGS2
3 response to oxidative stress GO:0006979 9.71 TP53 PTGS2 OGG1 GPX3
4 regulation of protein phosphorylation GO:0001932 9.65 SOCS3 SOCS1 RAD51
5 negative regulation of protein kinase activity GO:0006469 9.62 SOCS3 SOCS1 GSTP1 CDKN2A
6 replicative senescence GO:0090399 9.57 TP53 CDKN2A
7 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.56 SOCS3 SOCS1
8 negative regulation of tyrosine phosphorylation of STAT protein GO:0042532 9.55 SOCS3 SOCS1
9 glutathione metabolic process GO:0006749 9.55 GSTZ1 GSTP1 GSTM5 GSTM3 GSTM2
10 negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060315 9.54 GSTO1 GSTM2
11 cellular response to arsenic-containing substance GO:0071243 9.52 GSTO2 GSTO1
12 L-ascorbic acid metabolic process GO:0019852 9.51 GSTO2 GSTO1
13 cellular oxidant detoxification GO:0098869 9.5 PTGS2 GSTZ1 GSTP1 GSTO2 GSTO1 GSTM2
14 positive regulation of ryanodine-sensitive calcium-release channel activity GO:0060316 9.49 GSTO1 GSTM2
15 negative regulation of immature T cell proliferation in thymus GO:0033088 9.46 ERBB2 CDKN2A
16 nitrobenzene metabolic process GO:0018916 9.43 GSTM3 GSTM2
17 xenobiotic catabolic process GO:0042178 9.43 GSTO1 GSTM3 GSTM2
18 cellular detoxification of nitrogen compound GO:0070458 9.37 GSTM3 GSTM2
19 glutathione derivative biosynthetic process GO:1901687 9.17 GSTZ1 GSTP1 GSTO2 GSTO1 GSTM5 GSTM3

Molecular functions related to Barrett's Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.23 TP53 TAGLN2 SOCS3 SOCS1 S100A10 RAD51
2 transferase activity GO:0016740 10.09 PTGS2 GSTZ1 GSTP1 GSTO2 GSTO1 GSTM5
3 identical protein binding GO:0042802 10.01 TP53 RAD51 GSTZ1 GSTO2 GSTM5 GSTM3
4 protein homodimerization activity GO:0042803 9.95 TP53 S100A10 PTGS2 GSTZ1 GSTM3 GSTM2
5 enzyme binding GO:0019899 9.85 TP53 RAD51 PTGS2 GSTM3 GSTM2
6 1-phosphatidylinositol-3-kinase regulator activity GO:0046935 9.49 SOCS3 SOCS1
7 methylarsonate reductase activity GO:0050610 9.37 GSTO2 GSTO1
8 glutathione binding GO:0043295 9.33 GSTP1 GSTM3 GSTM2
9 glutathione dehydrogenase (ascorbate) activity GO:0045174 9.32 GSTO2 GSTO1
10 glutathione peroxidase activity GO:0004602 9.26 GSTZ1 GSTP1 GSTM2 GPX3
11 glutathione transferase activity GO:0004364 9.17 GSTZ1 GSTP1 GSTO2 GSTO1 GSTM5 GSTM3

Sources for Barrett's Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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