MCID: BRR002
MIFTS: 43

Barrett's Adenocarcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Barrett's Adenocarcinoma

MalaCards integrated aliases for Barrett's Adenocarcinoma:

Name: Barrett's Adenocarcinoma 12 15 74
Barrett Adenocarcinoma 12 17
Adenocarcinoma Arising in Barrett's Mucosa 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7941
NCIt 51 C7027
UMLS 74 C1332460

Summaries for Barrett's Adenocarcinoma

MalaCards based summary : Barrett's Adenocarcinoma, also known as barrett adenocarcinoma, is related to adenocarcinoma and squamous cell carcinoma. An important gene associated with Barrett's Adenocarcinoma is TP53 (Tumor Protein P53), and among its related pathways/superpathways are DNA Double-Strand Break Repair and Endometrial cancer. The drugs acetic acid and Epinephrine have been mentioned in the context of this disorder. Affiliated tissues include lymph node, bone and heart, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and cellular

Related Diseases for Barrett's Adenocarcinoma

Diseases related to Barrett's Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 113)
# Related Disease Score Top Affiliating Genes
1 adenocarcinoma 31.4 CDKN2A ERBB2 PTGS2 TP53
2 squamous cell carcinoma 29.9 CDKN2A ERBB2 PTGS2 TP53 XRCC1
3 gastric adenocarcinoma 29.5 CDKN2A ERBB2 FHIT PTGS2 TP53
4 gastric cancer 29.2 CDKN2A ERBB2 FHIT PTGS2 TP53
5 protoplasmic astrocytoma 10.4 PTGS2 TP53
6 recurrent respiratory papillomatosis 10.4 PTGS2 TP53
7 gastric papillary adenocarcinoma 10.4 ERBB2 TP53
8 pleomorphic adenoma carcinoma 10.4 ERBB2 TP53
9 uterine corpus serous adenocarcinoma 10.4 ERBB2 TP53
10 breast squamous cell carcinoma 10.4 ERBB2 TP53
11 uterine body mixed cancer 10.4 ERBB2 TP53
12 glioma susceptibility 1 10.3 ERBB2 TP53
13 microglandular adenosis 10.3 ERBB2 TP53
14 bladder squamous cell carcinoma 10.3 CDKN2A TP53
15 keratinizing squamous cell carcinoma 10.3 CDKN2A TP53
16 breast papillomatosis 10.3 CDKN2A ERBB2
17 spitz nevus 10.3 CDKN2A TP53
18 bowenoid papulosis 10.3 CDKN2A PTGS2
19 bladder carcinoma in situ 10.3 CDKN2A TP53
20 breast benign neoplasm 10.3 ERBB2 TP53
21 vulva squamous cell carcinoma 10.3 CDKN2A TP53
22 fallopian tube endometrioid adenocarcinoma 10.3 CDKN2A ERBB2
23 scrotal carcinoma 10.3 CDKN2A TP53
24 thoracic benign neoplasm 10.3 ERBB2 TP53
25 thyroid lymphoma 10.3 CDKN2A TP53
26 uterine corpus cancer 10.3 ERBB2 TP53
27 vulvar disease 10.3 CDKN2A TP53
28 nasal cavity adenocarcinoma 10.3 CDKN2A TP53
29 bartholin's gland disease 10.3 CDKN2A TP53
30 vulval paget's disease 10.3 CDKN2A ERBB2
31 anal squamous cell carcinoma 10.3 CDKN2A TP53
32 balanitis xerotica obliterans 10.3 CDKN2A PTGS2
33 glycogen-rich clear cell breast carcinoma 10.3 CDKN2A TP53
34 gastric adenosquamous carcinoma 10.3 CDKN2A TP53
35 anogenital venereal wart 10.3 CDKN2A TP53
36 vulva adenocarcinoma 10.3 CDKN2A ERBB2
37 cervix uteri carcinoma in situ 10.3 CDKN2A TP53
38 uterus carcinoma in situ 10.3 CDKN2A TP53
39 meningeal melanomatosis 10.3 CDKN2A TP53
40 dedifferentiated liposarcoma 10.3 CDKN2A TP53
41 endocervical adenocarcinoma 10.3 CDKN2A TP53
42 esophagus adenocarcinoma 10.2 ERBB2 PTGS2 TP53
43 ductal carcinoma in situ 10.2 ERBB2 PTGS2 TP53
44 non-proliferative fibrocystic change of the breast 10.2 ERBB2 TP53 XRCC1
45 stomach disease 10.2 ERBB2 PTGS2 TP53
46 uterine carcinosarcoma 10.2 ERBB2 PTGS2 TP53
47 penile disease 10.2 CDKN2A TP53
48 papilledema 10.2 OGG1 TP53
49 cardia cancer 10.2 TP53 XRCC1
50 cervix small cell carcinoma 10.2 CDKN2A TP53

Graphical network of the top 20 diseases related to Barrett's Adenocarcinoma:



Diseases related to Barrett's Adenocarcinoma

Symptoms & Phenotypes for Barrett's Adenocarcinoma

GenomeRNAi Phenotypes related to Barrett's Adenocarcinoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.02 ERCC2 OGG1 RAD51 TP53 XRCC1

MGI Mouse Phenotypes related to Barrett's Adenocarcinoma:

47 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.18 ADIPOR1 ADIPOR2 CDKN2A ERBB2 ERCC2 OGG1
2 behavior/neurological MP:0005386 10.15 ADIPOR1 ADIPOR2 CDKN2A ERBB2 ERCC2 OGG1
3 homeostasis/metabolism MP:0005376 10.1 ADIPOR1 ADIPOR2 CDKN2A ERBB2 ERCC2 FHIT
4 growth/size/body region MP:0005378 10.09 ADIPOR1 ADIPOR2 CDKN2A ERBB2 ERCC2 PTGS2
5 embryo MP:0005380 9.93 CDKN2A ERBB2 PTGS2 RAD51 TP53 XRCC1
6 adipose tissue MP:0005375 9.91 ADIPOR1 ADIPOR2 ERCC2 PTGS2 TP53
7 mortality/aging MP:0010768 9.91 CDKN2A ERBB2 ERCC2 FHIT OGG1 PTGS2
8 integument MP:0010771 9.85 CDKN2A ERBB2 ERCC2 FHIT PTGS2 TP53
9 liver/biliary system MP:0005370 9.8 ADIPOR1 ADIPOR2 CDKN2A OGG1 PTGS2 TP53
10 neoplasm MP:0002006 9.76 CDKN2A ERBB2 ERCC2 FHIT OGG1 PTGS2
11 nervous system MP:0003631 9.56 ADIPOR2 CDKN2A ERBB2 ERCC2 OGG1 PTGS2
12 skeleton MP:0005390 9.17 ADIPOR1 ADIPOR2 CDKN2A ERBB2 ERCC2 PTGS2

Drugs & Therapeutics for Barrett's Adenocarcinoma

Drugs for Barrett's Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
acetic acid Approved 64-19-7 176
2
Epinephrine Approved, Vet_approved Not Applicable 51-43-4 5816
3
Racepinephrine Approved Not Applicable 329-65-7 838
4
Vitamin A Approved, Nutraceutical, Vet_approved 22737-96-8, 68-26-8, 11103-57-4 9904001 445354
5 Anti-Bacterial Agents
6
Retinol acetate 127-47-9 10245972
7 Retinol palmitate
8 Anti-Infective Agents
9 retinol
10 Adjuvants, Immunologic
11 Immunologic Factors
12 Protective Agents
13 Epinephryl borate Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Aceto-whitening in the Assessment of Gastrointestinal Neoplasia Unknown status NCT01618643
2 ESD Versus EMR for Treatment of Early Barrett`s Adenocarcinoma Completed NCT01871636 Not Applicable
3 Neoplastic Barrett Esophagus: Endoscopic Piecemeal vs. En Bloc Resection Recruiting NCT03427346 Not Applicable
4 Endoscopic Mucosal Resection and Cellular Matrix Enrolling by invitation NCT03240679 Not Applicable

Search NIH Clinical Center for Barrett's Adenocarcinoma

Genetic Tests for Barrett's Adenocarcinoma

Anatomical Context for Barrett's Adenocarcinoma

MalaCards organs/tissues related to Barrett's Adenocarcinoma:

42
Lymph Node, Bone, Heart, Endothelial

Publications for Barrett's Adenocarcinoma

Articles related to Barrett's Adenocarcinoma:

(show top 50) (show all 107)
# Title Authors Year
1
Genome-Wide Analysis of Barrett's Adenocarcinoma. A First Step Towards Identifying Patients at Risk and Developing Therapeutic Paths. ( 29223109 )
2018
2
Treatment of long-segment Barrett's adenocarcinoma by complete circular endoscopic submucosal dissection: a case report. ( 29351773 )
2018
3
Reduced I+GlcNAc glycosylation on gastric gland mucin is a biomarker of malignant potential for gastric cancer, Barrett's adenocarcinoma, and pancreatic cancer. ( 29658052 )
2018
4
Minimally invasive esophagectomy for Barrett's adenocarcinoma. ( 30505964 )
2018
5
Endoscopic Treatment of Early Barrett's Adenocarcinoma and Dysplasia: Focus on Submucosal Cancer. ( 30176662 )
2018
6
Buried Barrett's Adenocarcinoma Clearly Demonstrated with Acetic Acid Chromoendoscopy. ( 30166635 )
2018
7
Tumor location is a risk factor for lymph node metastasis in superficial Barrett's adenocarcinoma. ( 28924592 )
2017
8
Impact of RAD51C-mediated Homologous Recombination on Genomic Integrity in Barrett's Adenocarcinoma Cells. ( 29399538 )
2017
9
Proton Pump Inhibitors Display Antitumor Effects in Barrett's Adenocarcinoma Cells. ( 27932981 )
2016
10
A case of Barrett's adenocarcinoma with marked endoscopic morphological changes in Barrett's esophagus over a long follow-up period of 15a88years. ( 26946036 )
2016
11
A case of simultaneous esophageal squamous cell carcinoma and Barrett's adenocarcinoma. ( 27220657 )
2016
12
Single center experience of endoscopic submucosal dissection (ESD) in early Barrett's adenocarcinoma. ( 25294533 )
2015
13
Clinical outcomes of endoscopic submucosal dissection for superficial Barrett's adenocarcinoma. ( 24565073 )
2014
14
The evil lies below the surface: Subsquamous tumor extension in Barrett's adenocarcinoma. ( 26134612 )
2014
15
Ischemic heart disease, factor predisposing to Barrett's adenocarcinoma: A case control study. ( 25133047 )
2014
16
Volumetric laser endomicroscopy detects subsquamous Barrett's adenocarcinoma. ( 24496431 )
2014
17
Differences in the Characteristics of Barrett's Esophagus and Barrett's Adenocarcinoma between the United States and Japan. ( 23606979 )
2013
18
A second-generation 2-Methoxyestradiol prodrug is effective against Barrett's adenocarcinoma in a mouse xenograft model. ( 23288782 )
2013
19
Targeting homologous recombination and telomerase in Barrett's adenocarcinoma: impact on telomere maintenance, genomic instability and tumor growth. ( 23604115 )
2013
20
Reduced expression of I+GlcNAc in Barrett's oesophagus adjacent to Barrett's adenocarcinoma - a possible biomarker to predict the malignant potential of Barrett's oesophagus. ( 24117499 )
2013
21
Small Barrett's adenocarcinoma, 3 mm in size, in long-segment Barrett's esophagus detected after 4 years of follow up. ( 23617677 )
2013
22
Current status of endoscopic diagnosis and treatment of superficial Barrett's adenocarcinoma in Asia-Pacific region. ( 23617667 )
2013
23
Barrett's adenocarcinoma in long-segment Barrett's esophagus successfully detected by narrow-band imaging with magnifying endoscopy. ( 23617678 )
2013
24
GERD-Barrett-Adenocarcinoma: Do We Have Suitable Prognostic and Predictive Molecular Markers? ( 23573078 )
2013
25
Increased expression of the 5-lipoxygenase pathway and its cellular localization in Barrett's adenocarcinoma. ( 22690932 )
2012
26
Targeting PI3K and RAD51 in Barrett's adenocarcinoma: impact on DNA damage checkpoints, expression profile and tumor growth. ( 22399496 )
2012
27
Clinicopathological characteristics of human epidermal growth factor receptor 2-positive Barrett's adenocarcinoma. ( 23180947 )
2012
28
MALDI imaging mass spectrometry reveals COX7A2, TAGLN2 and S100-A10 as novel prognostic markers in Barrett's adenocarcinoma. ( 22365974 )
2012
29
Barrett's adenocarcinoma of the esophagus: better outcomes through new methods of diagnosis and treatment. ( 21629515 )
2011
30
How much length of the distal esophagus is removed by transhiatal approach for squamous cell carcinoma and Barrett's adenocarcinoma in Japanese patients? ( 22234066 )
2011
31
Human Barrett's adenocarcinoma of the esophagus, associated myofibroblasts, and endothelium can arise from bone marrow-derived cells after allogeneic stem cell transplant. ( 20677919 )
2011
32
Genomic evolution in Barrett's adenocarcinoma cells: critical roles of elevated hsRAD51, homologous recombination and Alu sequences in the genome. ( 21423218 )
2011
33
A rare case of Barrett's adenocarcinoma including squamous cell carcinoma component. ( 26190613 )
2011
34
Barrett's adenocarcinoma 52 years after subtotal esophagectomy for pediatric peptic stricture. ( 20103354 )
2010
35
A case of early Barrett's adenocarcinoma repeatedly developing multiple metachronous lesions shortly after endoscopic therapy: an analysis for genetic and epigenetic alterations. ( 20650453 )
2010
36
Anticancer activity of a broccoli derivative, sulforaphane, in barrett adenocarcinoma: potential use in chemoprevention and as adjuvant in chemotherapy. ( 21151478 )
2010
37
Genome-wide analysis of genetic alterations in Barrett's adenocarcinoma using single nucleotide polymorphism arrays. ( 18663352 )
2009
38
Aspirin is not chemoprotective for Barrett's adenocarcinoma of the oesophagus in multicentre cohort. ( 19620873 )
2009
39
Differences in the definitions used for esophageal and gastric diseases in different countries: endoscopic definition of the esophagogastric junction, the precursor of Barrett's adenocarcinoma, the definition of Barrett's esophagus, and histologic criteria for mucosal adenocarcinoma or high-grade dysplasia. ( 19828957 )
2009
40
Cardiac rather than intestinal-type background in endoscopic resection specimens of minute Barrett adenocarcinoma. ( 18755496 )
2009
41
Re: Cardiac rather than intestinal-type background in endoscopic resection specimens of minute Barrett adenocarcinoma. ( 19616700 )
2009
42
Cardiac rather than intestinal-type background in endoscopic resection specimens of minute Barrett adenocarcinoma. ( 19913679 )
2009
43
Telomere maintenance in laser capture microdissection-purified Barrett's adenocarcinoma cells and effect of telomerase inhibition in vivo. ( 18676772 )
2008
44
Corn-derived carbohydrate inositol hexaphosphate inhibits Barrett's adenocarcinoma growth by pro-apoptotic mechanisms. ( 18202808 )
2008
45
No association between hOGG1, XRCC1, and XPD polymorphisms and risk of reflux esophagitis, Barrett's esophagus, or esophageal adenocarcinoma: results from the factors influencing the Barrett's adenocarcinoma relationship case-control study. ( 18349297 )
2008
46
Comparison of DNA histograms by standard flow cytometry and image cytometry on sections in Barrett's adenocarcinoma. ( 18513411 )
2008
47
Results of a multimodal therapy in patients with stage IV Barrett's adenocarcinoma. ( 18802733 )
2008
48
Immunohistochemical expression of p63 in esophageal Barrett's adenocarcinoma. ( 21479434 )
2008
49
Methylation of SOCS-3 and SOCS-1 in the carcinogenesis of Barrett's adenocarcinoma. ( 17376806 )
2007
50
Usefulness of magnifying endoscopy with narrow band imaging for the detection of specialized intestinal metaplasia in columnar-lined esophagus and Barrett's adenocarcinoma. ( 17185078 )
2007

Variations for Barrett's Adenocarcinoma

Copy number variations for Barrett's Adenocarcinoma from CNVD:

7 (show top 50) (show all 60)
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 39411 10 114900000 119100000 Gain ABLIM1 Barrett''s adenocarcinoma
2 39412 10 114900000 119100000 Gain AFAP1L2 Barrett''s adenocarcinoma
3 42467 10 34500000 38800000 Gain CCNY Barrett''s adenocarcinoma
4 42468 10 34500000 38800000 Gain CUL2 Barrett''s adenocarcinoma
5 65755 12 21200000 26300000 Gain SSPN Barrett''s adenocarcinoma
6 66184 12 26300000 27700000 Gain ARNTL2 Barrett''s adenocarcinoma
7 66185 12 26300000 27700000 Gain TM7SF3 Barrett''s adenocarcinoma
8 73111 12 91200000 94800000 Gain KRT19P2 Barrett''s adenocarcinoma
9 74577 13 109100000 114142980 Gain Barrett''s adenocarcinoma
10 75797 13 24400000 26700000 Gain Barrett''s adenocarcinoma
11 79796 13 77800000 86500000 Gain SOX1 Barrett''s adenocarcinoma
12 81034 14 100400000 102200000 Gain SLC25A29 Barrett''s adenocarcinoma
13 88798 14 95400000 100400000 Gain TCL1A Barrett''s adenocarcinoma
14 88799 14 95400000 100400000 Gain TCL1B Barrett''s adenocarcinoma
15 107009 17 11200000 15900000 Loss RICH2 Barrett''s adenocarcinoma
16 114436 17 47600000 54900000 Gain CUEDC1 Barrett''s adenocarcinoma
17 115246 17 55600000 58400000 Gain LRRC37A3 Barrett''s adenocarcinoma
18 116543 17 6800000 11200000 Loss MYH13 Barrett''s adenocarcinoma
19 116544 17 6800000 11200000 Loss TP53 Barrett''s adenocarcinoma
20 122243 18 54400000 57100000 Loss Barrett''s adenocarcinoma
21 125938 19 16100000 19800000 Gain AP1M1 Barrett''s adenocarcinoma
22 127254 19 30200000 37100000 Gain ZNF536 Barrett''s adenocarcinoma
23 134771 2 106700000 108600000 Gain GCC2 Barrett''s adenocarcinoma
24 141056 2 205600000 209100000 Gain Barrett''s adenocarcinoma
25 144816 2 29800000 31900000 Gain ALK Barrett''s adenocarcinoma
26 151523 20 22300000 25700000 Gain SSTR4 Barrett''s adenocarcinoma
27 151524 20 22300000 25700000 Loss CST4 Barrett''s adenocarcinoma
28 152533 20 31500000 33900000 Gain CEP250 Barrett''s adenocarcinoma
29 154854 20 49200000 54400000 Gain CBLN4 Barrett''s adenocarcinoma
30 170891 3 161200000 169200000 Gain BCHE Barrett''s adenocarcinoma
31 172565 3 184200000 186000000 Gain MAGEF1 Barrett''s adenocarcinoma
32 172566 3 184200000 186000000 Gain MUC13 Barrett''s adenocarcinoma
33 172567 3 184200000 186000000 Gain VPS8 Barrett''s adenocarcinoma
34 177566 3 58500000 63700000 Loss Barrett''s adenocarcinoma
35 196847 5 172200000 176500000 Gain MSX2 Barrett''s adenocarcinoma
36 203652 6 1 2300000 Gain Barrett''s adenocarcinoma
37 204555 6 11200000 13500000 Gain PHACTR1 Barrett''s adenocarcinoma
38 205460 6 127300000 130400000 Gain C6orf190 Barrett''s adenocarcinoma
39 205461 6 127300000 130400000 Gain PTPRK Barrett''s adenocarcinoma
40 212308 6 36800000 40600000 Gain DNAH8 Barrett''s adenocarcinoma
41 219021 7 120900000 123600000 Loss SLC13A1 Barrett''s adenocarcinoma
42 219022 7 120900000 123600000 Loss TAS2R16 Barrett''s adenocarcinoma
43 225150 7 43300000 46600000 Gain RAMP3 Barrett''s adenocarcinoma
44 225833 7 50900000 53900000 Gain Barrett''s adenocarcinoma
45 227260 7 66100000 71800000 Gain CALN1 Barrett''s adenocarcinoma
46 227261 7 66100000 71800000 Gain WBSCR17 Barrett''s adenocarcinoma
47 227796 7 7200000 13300000 Gain ICA1 Barrett''s adenocarcinoma
48 231014 8 101600000 106100000 Gain ANKRD46 Barrett''s adenocarcinoma
49 231021 8 101600000 106100000 Gain RNF19 Barrett''s adenocarcinoma
50 232059 8 110600000 112200000 Gain PKHD1L1 Barrett''s adenocarcinoma

Expression for Barrett's Adenocarcinoma

Search GEO for disease gene expression data for Barrett's Adenocarcinoma.

Pathways for Barrett's Adenocarcinoma

Pathways related to Barrett's Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.93 ERCC2 OGG1 RAD51 TP53 XRCC1
2
Show member pathways
12.61 CDKN2A ERBB2 RAD51 TP53
3
Show member pathways
12.41 CDKN2A ERBB2 FHIT TP53
4 12.28 CDKN2A ERBB2 PTGS2 RAD51 TP53
5 12.14 CDKN2A ERBB2 PTGS2 TP53
6
Show member pathways
11.96 ERCC2 OGG1 RAD51 TP53 XRCC1
7 11.81 CDKN2A ERCC2 TP53
8
Show member pathways
11.81 ADIPOR1 ADIPOR2 TP53
9 11.67 CDKN2A ERBB2 TP53
10 11.55 FHIT PTGS2 TP53
11 11.49 CDKN2A ERCC2 RAD51 TP53 XRCC1
12 11.44 CDKN2A ERCC2 TP53
13 11.36 CDKN2A ERBB2 TP53
14 11.3 CDKN2A ERBB2 TP53
15 11.08 CDKN2A TP53
16 11.02 RAD51 TP53
17 10.84 CDKN2A TP53
18
Show member pathways
10.82 CDKN2A TP53

GO Terms for Barrett's Adenocarcinoma

Biological processes related to Barrett's Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 DNA repair GO:0006281 9.76 ERCC2 OGG1 RAD51 XRCC1
2 aging GO:0007568 9.71 ERCC2 OGG1 PTGS2
3 fatty acid metabolic process GO:0006631 9.69 ADIPOR1 ADIPOR2 PTGS2
4 response to oxidative stress GO:0006979 9.67 ERCC2 OGG1 PTGS2
5 cellular response to DNA damage stimulus GO:0006974 9.65 ERCC2 OGG1 RAD51 TP53 XRCC1
6 cellular response to ionizing radiation GO:0071479 9.55 RAD51 TP53
7 intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 9.52 FHIT TP53
8 fatty acid oxidation GO:0019395 9.48 ADIPOR1 ADIPOR2
9 replicative senescence GO:0090399 9.43 CDKN2A TP53
10 regulation of fatty acid biosynthetic process GO:0042304 9.4 ADIPOR1 ADIPOR2
11 adiponectin-activated signaling pathway GO:0033211 9.37 ADIPOR1 ADIPOR2
12 nucleotide-excision repair GO:0006289 9.33 ERCC2 OGG1 TP53
13 negative regulation of immature T cell proliferation in thymus GO:0033088 9.32 CDKN2A ERBB2
14 base-excision repair GO:0006284 9.13 OGG1 TP53 XRCC1
15 negative regulation of cell growth GO:0030308 8.92 ADIPOR1 ADIPOR2 CDKN2A TP53

Molecular functions related to Barrett's Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.73 ADIPOR1 ADIPOR2 ERBB2 FHIT RAD51 TP53
2 protein heterodimerization activity GO:0046982 9.71 ADIPOR1 ADIPOR2 ERBB2 TP53
3 nucleotide binding GO:0000166 9.67 ERBB2 ERCC2 FHIT RAD51
4 enzyme binding GO:0019899 9.62 PTGS2 RAD51 TP53 XRCC1
5 protein C-terminus binding GO:0008022 9.61 ERBB2 ERCC2 RAD51
6 damaged DNA binding GO:0003684 9.33 ERCC2 OGG1 XRCC1
7 adiponectin binding GO:0055100 8.96 ADIPOR1 ADIPOR2
8 adipokinetic hormone receptor activity GO:0097003 8.62 ADIPOR1 ADIPOR2

Sources for Barrett's Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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