MCID: BRT060
MIFTS: 34

Bartholin's Gland Disease

Categories: Endocrine diseases, Reproductive diseases

Aliases & Classifications for Bartholin's Gland Disease

MalaCards integrated aliases for Bartholin's Gland Disease:

Name: Bartholin's Gland Disease 12 15
Bartholin Gland Disease 17

Classifications:



External Ids:

Disease Ontology 12 DOID:60002
ICD10 34 N75

Summaries for Bartholin's Gland Disease

Disease Ontology : 12 Disease that is located in Bartholin's gland.

MalaCards based summary : Bartholin's Gland Disease, also known as bartholin gland disease, is related to breast malignant phyllodes tumor and uterine body mixed cancer. An important gene associated with Bartholin's Gland Disease is SLC10A2 (Solute Carrier Family 10 Member 2), and among its related pathways/superpathways are Pathways in cancer and Signaling by ERBB4. Affiliated tissues include breast, lung and testis, and related phenotypes are cellular and homeostasis/metabolism

Wikipedia : 77 The Bartholin''s glands (also called Bartholin glands or greater vestibular glands) are two pea sized... more...

Related Diseases for Bartholin's Gland Disease

Diseases related to Bartholin's Gland Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 217)
# Related Disease Score Top Affiliating Genes
1 breast malignant phyllodes tumor 10.5 PGR TP53
2 uterine body mixed cancer 10.5 PGR TP53
3 olfactory groove meningioma 10.5 PGR TP53
4 retroperitoneal leiomyosarcoma 10.5 ERBB3 PGR
5 sclerosing liposarcoma 10.5 PAX8 TP53
6 sarcomatoid mesothelioma 10.5 CDKN2A NAPSA
7 bizarre leiomyoma 10.5 CDKN2A PGR
8 thyroid lymphoma 10.4 CDKN2A TP53
9 megaesophagus 10.4 CDKN2A TP53
10 vulva squamous cell carcinoma 10.4 CDKN2A TP53
11 scrotal carcinoma 10.4 CDKN2A TP53
12 bladder squamous cell carcinoma 10.4 CDKN2A TP53
13 anal squamous cell carcinoma 10.4 CDKN2A TP53
14 keratinizing squamous cell carcinoma 10.4 CDKN2A TP53
15 gastric adenosquamous carcinoma 10.4 CDKN2A TP53
16 spitz nevus 10.4 CDKN2A TP53
17 progesterone resistance 10.4 ESR1 PGR
18 progesterone-receptor positive breast cancer 10.4 ESR1 PGR
19 water-clear cell adenoma 10.4 GATA3 PAX8
20 estrogen excess 10.4 ESR1 PGR
21 intramuscular hemangioma 10.4 ESR1 PGR
22 deep angioma 10.4 ESR1 PGR
23 endometrium carcinoma in situ 10.4 PGR TP53
24 papillary adenoma 10.4 KRT7 NAPSA
25 breast squamous cell carcinoma 10.4 CD86 TP53
26 thymus adenocarcinoma 10.4 KRT7 NAPSA
27 pancreatic serous cystadenoma 10.4 KRT7 PGR
28 sensory organ benign neoplasm 10.4 KRT7 PAX8
29 benign metastasizing leiomyoma 10.4 KRT7 PGR
30 renal pelvis adenocarcinoma 10.4 KRT7 PAX8
31 skin carcinoma in situ 10.4 CD86 CDKN2A
32 vestibular gland benign neoplasm 10.3 ESR1 PGR
33 anal canal carcinoma 10.3 CDKN2A KRT7
34 benign breast phyllodes tumor 10.3 MME PGR
35 nasal cavity cancer 10.3 CDKN2A KRT7
36 bartholin's gland adenoma 10.3 ESR1 PGR
37 cystic nephroma 10.3 MME PGR
38 myxoid leiomyosarcoma 10.3 MME PGR
39 vulvar syringoma 10.3 ESR1 PGR
40 bile duct adenoma 10.3 CDKN2A KRT7
41 lung leiomyoma 10.3 ESR1 PGR
42 clear cell hidradenoma 10.3 MME PAX8
43 glassy cell carcinoma of the cervix 10.3 ESR1 PGR
44 vulvar dystrophy 10.3 CDKN2A PGR
45 vulvar benign neoplasm 10.3 ESR1 PGR
46 trigonitis 10.3 ESR1 PGR
47 vulvar leiomyoma 10.3 ESR1 PGR
48 eccrine papillary adenocarcinoma 10.3 KRT7 PGR
49 ovarian disease 10.3 ESR1 PGR TP53
50 nephrogenic adenoma of urinary bladder 10.3 KRT7 PAX8

Graphical network of the top 20 diseases related to Bartholin's Gland Disease:



Diseases related to Bartholin's Gland Disease

Symptoms & Phenotypes for Bartholin's Gland Disease

MGI Mouse Phenotypes related to Bartholin's Gland Disease:

47 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.3 AR CD86 CDKN2A ERBB3 ESR1 GATA3
2 homeostasis/metabolism MP:0005376 10.29 AR CD86 CDKN2A ERBB3 ESR1 GATA3
3 behavior/neurological MP:0005386 10.23 AR CALB2 CD86 CDKN2A ERBB3 ESR1
4 cardiovascular system MP:0005385 10.22 AR CDKN2A ERBB3 ESR1 GATA3 PAX8
5 endocrine/exocrine gland MP:0005379 10.22 AR CD86 CDKN2A ERBB3 ESR1 GATA3
6 immune system MP:0005387 10.19 AR CD86 CDKN2A ERBB3 ESR1 GATA3
7 digestive/alimentary MP:0005381 10.15 AR CDKN2A ERBB3 ESR1 GATA3 PIP
8 embryo MP:0005380 10.14 AR CDKN2A ERBB3 ESR1 GATA3 PAX8
9 integument MP:0010771 10.08 AR CDKN2A ERBB3 ESR1 GATA3 MME
10 muscle MP:0005369 10.03 AR CD86 CDKN2A ERBB3 ESR1 GATA3
11 nervous system MP:0003631 10.02 AR CALB2 CD86 CDKN2A ERBB3 ESR1
12 liver/biliary system MP:0005370 9.93 AR CDKN2A ESR1 MME SLC10A2 TP53
13 neoplasm MP:0002006 9.88 AR CDKN2A ERBB3 ESR1 PGR TP53
14 normal MP:0002873 9.86 AR CALB2 ERBB3 ESR1 GATA3 PAX8
15 no phenotypic analysis MP:0003012 9.8 CDKN2A ESR1 GATA3 PAX8 PGR TP53
16 pigmentation MP:0001186 9.55 AR CDKN2A ERBB3 GATA3 TP53
17 renal/urinary system MP:0005367 9.43 AR ESR1 GATA3 KRT7 PAX8 TP53
18 reproductive system MP:0005389 9.23 AR CDKN2A ESR1 GATA3 PAX8 PGR

Drugs & Therapeutics for Bartholin's Gland Disease

Search Clinical Trials , NIH Clinical Center for Bartholin's Gland Disease

Genetic Tests for Bartholin's Gland Disease

Anatomical Context for Bartholin's Gland Disease

MalaCards organs/tissues related to Bartholin's Gland Disease:

42
Breast, Lung, Testis, Cervix, Thymus, Bone, Smooth Muscle

Publications for Bartholin's Gland Disease

Variations for Bartholin's Gland Disease

Expression for Bartholin's Gland Disease

Search GEO for disease gene expression data for Bartholin's Gland Disease.

Pathways for Bartholin's Gland Disease

Pathways related to Bartholin's Gland Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.75 AR CDKN2A ESR1 PAX8 TP53
2
Show member pathways
11.47 ERBB3 ESR1 PGR
3
Show member pathways
11.29 AR ESR1 PGR
4 11.02 AR ESR1 GATA3

GO Terms for Bartholin's Gland Disease

Cellular components related to Bartholin's Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 8.92 AR ESR1 GATA3 TP53

Biological processes related to Bartholin's Gland Disease according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.91 AR CDKN2A ESR1 GATA3 PAX8 PGR
2 protein deubiquitination GO:0016579 9.8 AR ESR1 GATA3 TP53
3 kidney development GO:0001822 9.72 GATA3 MME PAX8
4 male gonad development GO:0008584 9.71 AR ESR1 GATA3
5 positive regulation of protein kinase B signaling GO:0051897 9.71 CD86 ERBB3 ESR1 GATA3
6 transcription, DNA-templated GO:0006351 9.63 AR ESR1 PAX8
7 positive regulation of gene expression GO:0010628 9.63 AR CDKN2A ERBB3 GATA3 PIP TP53
8 steroid hormone mediated signaling pathway GO:0043401 9.61 AR ESR1 PGR
9 uterus development GO:0060065 9.57 ESR1 GATA3
10 mammary gland alveolus development GO:0060749 9.56 AR ESR1
11 mesonephros development GO:0001823 9.52 GATA3 PAX8
12 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.51 ESR1 TP53
13 otic vesicle development GO:0071599 9.48 GATA3 PAX8
14 positive regulation of thyroid hormone generation GO:2000611 9.32 GATA3 PAX8
15 tertiary branching involved in mammary gland duct morphogenesis GO:0060748 9.26 AR PGR
16 positive regulation of transcription, DNA-templated GO:0045893 9.17 AR CD86 CDKN2A ESR1 GATA3 PAX8
17 replicative senescence GO:0090399 9.13 CDKN2A MME TP53

Molecular functions related to Bartholin's Gland Disease according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.88 AR ESR1 GATA3 PAX8 PGR
2 DNA-binding transcription factor activity GO:0003700 9.88 AR ESR1 GATA3 PAX8 PGR TP53
3 zinc ion binding GO:0008270 9.85 AR ESR1 GATA3 MME PGR TP53
4 enzyme binding GO:0019899 9.8 AR ESR1 PGR TP53
5 transcription regulatory region DNA binding GO:0044212 9.73 AR GATA3 PAX8 TP53
6 ATPase binding GO:0051117 9.63 AR ESR1 PGR
7 transcription factor binding GO:0008134 9.55 AR CDKN2A ESR1 GATA3 TP53
8 aspartic-type endopeptidase activity GO:0004190 9.51 NAPSA PIP
9 steroid hormone receptor activity GO:0003707 9.5 AR ESR1 PGR
10 nuclear receptor activity GO:0004879 9.43 AR ESR1 PGR
11 steroid binding GO:0005496 9.13 AR ESR1 PGR
12 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.1 AR ESR1 GATA3 PAX8 PGR TP53

Sources for Bartholin's Gland Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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