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MCID: BRT043
MIFTS: 35

Bartonellosis

Categories: Infectious diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Bartonellosis

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MalaCards integrated aliases for Bartonellosis:

Name: Bartonellosis 12 15
Bartonella Infections 44 73
Bartonella Infectious Disease 12
Rochalimaea Infection 12
Bartonelliasis 12

Classifications:

MalaCards categories:
Global: Infectious diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:11102
ICD10 33 A44 A44.9
ICD9CM 35 088.0
MeSH 44 D001474
NCIt 50 C84586
SNOMED-CT 68 17116008
UMLS 73 C0004771
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Summaries for Bartonellosis

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Disease Ontology : 12 A primary bacterial infectious disease that is caused by the bacteria of the genus Bartonella.

MalaCards based summary : Bartonellosis, also known as bartonella infections, is related to carrion's disease and cat-scratch disease. An important gene associated with Bartonellosis is HSPD1 (Heat Shock Protein Family D (Hsp60) Member 1), and among its related pathways/superpathways are Tuberculosis and Mitochondrial protein import. The drugs Azithromycin and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and liver, and related phenotypes are Decreased viability with cisplatin and Reduced mammosphere formation

Wikipedia : 76 Bartonellosis is an infectious disease produced by bacteria of the genus Bartonella.Bartonella species... more...

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Related Diseases for Bartonellosis

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Diseases related to Bartonellosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 carrion's disease 32.8 HSPE1 HSPD1 ASXL3
2 cat-scratch disease 32.4 HTRA1 HSPD1 EEA1 CS CORO1A
3 bacillary angiomatosis 31.6 STAB1 HSPE1 ATR
4 trench fever 11.4
5 neuroretinitis 10.2
6 sarcoma 10.1
7 babesiosis 10.1
8 kaposi sarcoma 10.0
9 ehrlichiosis 10.0
10 plague 10.0
11 endocarditis 10.0
12 human granulocytic anaplasmosis 10.0 HSPD1 ATR
13 sennetsu fever 10.0 HSPE1 HSPD1
14 chancroid 10.0 HSPE1 HSPD1
15 leukodystrophy, hypomyelinating, 4 10.0 HSPE1 HSPD1
16 testicular disease 9.9 HSPE1 HSPD1
17 sleeping sickness 9.9
18 granulomatous hepatitis 9.9
19 leprosy 3 9.9 HSPE1 HSPD1
20 chronic kidney failure 9.9
21 hemolytic anemia 9.9
22 hepatitis 9.9
23 thrombocytopenia 9.9
24 salmonellosis 9.9
25 lyme disease 9.9
26 uveitis 9.9
27 hyperinsulinemic hypoglycemia 9.9
28 leptospirosis 9.9
29 kidney disease 9.9
30 leishmaniasis 9.9
31 viral infectious disease 9.9
32 iridocyclitis 9.9
33 yellow fever 9.9
34 hypoglycemia 9.9
35 mycobacterium tuberculosis 1 9.8 HSPE1 HSPD1
36 rheumatoid arthritis 9.8
37 arthritis 9.8
38 granuloma annulare 9.8
39 infective endocarditis 9.8
40 q fever 9.8
41 panniculitis 9.8
42 panic disorder 9.8
43 juvenile rheumatoid arthritis 9.8
44 meningitis 9.8
45 pyogenic granuloma 9.8
46 depression 9.8

Graphical network of the top 20 diseases related to Bartonellosis:



Diseases related to Bartonellosis
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Symptoms & Phenotypes for Bartonellosis

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GenomeRNAi Phenotypes related to Bartonellosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with cisplatin GR00101-A-4 8.96 ASXL3 ATR
2 Reduced mammosphere formation GR00396-S 8.92 ATR CS HSPD1 HSPE1
Sources

Drugs & Therapeutics for Bartonellosis

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Drugs for Bartonellosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4,Phase 3 83905-01-5 55185 447043
2
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
3
Ritonavir Approved, Investigational Phase 4,Phase 3 155213-67-5 392622
4
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
5
Nevirapine Approved Phase 4 129618-40-2 4463
6
Tenofovir Experimental, Investigational Phase 4 147127-20-6 464205
7 Hormone Antagonists Phase 4
8 Antineoplastic Agents, Hormonal Phase 4
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
10 glucocorticoids Phase 4
11 Hormones Phase 4
12 Anti-Inflammatory Agents Phase 4
13 Antiviral Agents Phase 4,Phase 3
14 Nucleic Acid Synthesis Inhibitors Phase 4
15 HIV Protease Inhibitors Phase 4,Phase 3
16 Anti-HIV Agents Phase 4,Phase 3
17 Cytochrome P-450 CYP3A Inducers Phase 4
18 Cytochrome P-450 Enzyme Inhibitors Phase 4
19 Anti-Infective Agents Phase 4,Phase 3
20 Atazanavir Sulfate Phase 4
21 Reverse Transcriptase Inhibitors Phase 4
22 Anti-Retroviral Agents Phase 4,Phase 3
23 Cytochrome P-450 CYP3A Inhibitors Phase 4
24
protease inhibitors Phase 4,Phase 3
25 Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Phase 4
26
Aldesleukin Approved Phase 3 85898-30-2, 110942-02-4
27 tannic acid Approved Phase 3
28
Benzocaine Approved, Investigational Phase 3 94-09-7, 1994-09-7 2337
29
Efavirenz Approved, Investigational Phase 3 154598-52-4 64139
30
Maraviroc Approved, Investigational Phase 3 376348-65-1 3002977
31
Fosamprenavir Approved Phase 3 226700-79-4 131536
32 Peripheral Nervous System Agents Phase 3
33 Analgesics Phase 3
34 Interleukin-2 Phase 3
35 Analgesics, Non-Narcotic Phase 3
36 Gentamicins Phase 3
37 Anti-Bacterial Agents Phase 3
38 Immunoglobulins
39 Antibodies
40 Liver Extracts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease Unknown status NCT01469702 Phase 4 prednison and azithromycin;prednison, azithromycin;prednison, Azenil
2 Nevirapine vs. Atazanavir Boosted With Ritonavir on a Background of Truvada in Human Immunodeficiency Virus (HIV) Infected Naive Patients (NEwArT) Completed NCT00552240 Phase 4 tenofovir DF 300 mg QD;tenofovir DF 300 mg QD;emtricitabine 200 mg QD;emtricitabine 200 mg QD;Nevirapine 200 mg BID;Atazanavir 300 mg;Ritonavir 100 mg
3 Interleukin-2 Plus Antiretroviral Therapy for HIV-Infected Patients With Low CD4+ Counts (SILCAAT Study) Completed NCT00013611 Phase 3 Proleukin
4 An International Study to Evaluate Recombinant Interleukin-2 in HIV Positive Patients Taking Anti-retroviral Therapy Completed NCT00004978 Phase 3 Recombinant interleukin-2 (rIL-2)
5 Immuno-stimulation With Maraviroc Combined to Antiretroviral Therapy in Advanced Late Diagnosed HIV-1 Infected Patients Completed NCT01348308 Phase 3 Maraviroc (Celsentri);Placebo
6 Intra-nodal Injection of Gentamicin for the Treatment of Suppurated Cat Scratch Disease's Lymphadenitis Recruiting NCT03132116 Phase 3 gentamicin;placebo
7 Bartonella in Liver Transplant Patients Recruiting NCT02595710

Search NIH Clinical Center for Bartonellosis

Cochrane evidence based reviews: bartonella infections

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Genetic Tests for Bartonellosis

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Anatomical Context for Bartonellosis

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MalaCards organs/tissues related to Bartonellosis:

41
Bone, Skin, Liver, Testes, Kidney, Endothelial, Bone Marrow
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Publications for Bartonellosis

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Articles related to Bartonellosis:

(show top 50) (show all 132)
# Title Authors Year
1
Ocular manifestations of bartonellosis. ( 30124532 )
2018
2
Evaluation of cell culture-grown Bartonella antigens in immunofluorescent antibody assays for the serological diagnosis of bartonellosis in dogs. ( 30307643 )
2018
3
Bartonella infections in humans dogs and cats. ( 29631316 )
2018
4
Bartonella infections in three species of Microtus: prevalence and genetic diversity, vertical transmission and the effect of concurrent Babesia microti infection on its success. ( 30165879 )
2018
5
Bartonella infections in cats and dogs including zoonotic aspects. ( 30514361 )
2018
6
Bartonellosis, One Health and all creatures great and small. ( 28133871 )
2017
7
Ocular Bartonellosis. ( 28778273 )
2017
8
Clinical Profile and Visual Outcome of Ocular Bartonellosis in Malaysia. ( 28265290 )
2017
9
Bartonellosis in Chronic Kidney Disease: An Unrecognized and Unsuspected Diagnosis. ( 28884961 )
2017
10
Bartonellosis ( 28613624 )
2017
11
Acute Unilateral Vision Loss in a Female Adolescent Due to Ocular Bartonellosis. ( 28398939 )
2017
12
Ultrasound imaging as the basis of a clinical diagnosis of systemic bartonellosis in a patient after bone marrow transplantation. A case report. ( 27446604 )
2016
13
Role of Whole-Body MR with DWIBS in child's Bartonellosis. ( 27598022 )
2016
14
Clinical determinants of Lyme borreliosis, babesiosis, bartonellosis, anaplasmosis, and ehrlichiosis in an Australian cohort. ( 25565883 )
2015
15
Neuroretinitis in ocular bartonellosis. ( 25453244 )
2015
16
Ocular bartonellosis in transplant recipients: two case reports and review of the literature. ( 26146758 )
2015
17
Paleomicrobiology of Bartonella infections. ( 26369716 )
2015
18
Hyperinsulinemic hypoglycemia syndrome in 2 dogs with bartonellosis. ( 24934703 )
2014
19
Neuroretinitis in ocular bartonellosis: a case series. ( 25120352 )
2014
20
Risk factors for human lice and bartonellosis among the homeless, San Francisco, California, USA. ( 25280380 )
2014
21
Bartonellosis: one health perspectives for an emerging infectious disease. ( 24936029 )
2014
22
Pathogenicity and treatment of Bartonella infections. ( 24933445 )
2014
23
Macular hole: a rare complication of ocular bartonellosis. ( 23681239 )
2013
24
Cat scratch disease and other Bartonella infections. ( 23654065 )
2013
25
Treatment outcomes of human bartonellosis: a systematic review and meta-analysis. ( 23602630 )
2013
26
Bartonella infections in deer keds (Lipoptena cervi) and moose (Alces alces) in Norway. ( 23104416 )
2013
27
Global distribution of Bartonella infections in domestic bovine and characterization of Bartonella bovis strains using multi-locus sequence typing. ( 24278342 )
2013
28
Chronic Bartonellosis in cats: what are the potential implications? ( 22918844 )
2012
29
Feline bartonellosis: we're just scratching the surface. ( 22918842 )
2012
30
Paradoxical response in ocular bartonellosis. ( 22057809 )
2012
31
Cryptogenic hepatitis and bartonellosis. ( 22307338 )
2012
32
Bartonella and Bartonella infections in China: from the clinic to the laboratory. ( 22304899 )
2012
33
Differences in the ecology of Bartonella infections of Apodemus flavicollis and Myodes glareolus in a boreal forest. ( 22336264 )
2012
34
Emerging incidence of Lyme borreliosis, babesiosis, bartonellosis, and granulocytic ehrlichiosis in Australia. ( 22267937 )
2011
35
Bartonellosis in cats: a role in uveitis? ( 21923819 )
2011
36
Disseminated bartonellosis presenting as neuroretinitis in a young adult with human immunodeficiency virus infection. ( 20216243 )
2010
37
Bartonellosis: an emerging infectious disease of zoonotic importance to animals and human beings. ( 20230432 )
2010
38
Bartonellosis diagnosis requires careful evaluation. ( 20835501 )
2010
39
Feline bartonellosis. ( 20933137 )
2010
40
The pathophysiology of the acute phase of human bartonellosis resembles AIDS. ( 19665314 )
2010
41
Bartonellosis. ( 20018462 )
2010
42
Bartonellosis, an increasingly recognized zoonosis. ( 20148999 )
2010
43
Inoculation bartonellosis in an adult: a case report. ( 20184210 )
2010
44
Flea-associated zoonotic diseases of cats in the USA: bartonellosis, flea-borne rickettsioses, and plague. ( 20185369 )
2010
45
Identification of Bartonella infections in febrile human patients from Thailand and their potential animal reservoirs. ( 20519614 )
2010
46
Bartonellosis causing bilateral Leber neuroretinitis: a case report. ( 19253255 )
2009
47
Ocular bartonellosis. ( 19319232 )
2009
48
Bartonellosis. ( 19362689 )
2009
49
Comparative medical features of canine and human bartonellosis. ( 19438635 )
2009
50
Bartonellosis as cause of death after red blood cell unit transfusion. ( 19728230 )
2009
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Variations for Bartonellosis

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Expression for Bartonellosis

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Search GEO for disease gene expression data for Bartonellosis.
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Pathways for Bartonellosis

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Pathways related to Bartonellosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Tuberculosis 37
11.05 CORO1A EEA1 HSPD1
2
Mitochondrial protein import 66
10.75 CS HSPD1
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GO Terms for Bartonellosis

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Cellular components related to Bartonellosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial matrix GO:0005759 9.33 CS HSPD1 HSPE1
2 early endosome GO:0005769 9.13 CORO1A EEA1 HSPD1
3 extracellular exosome GO:0070062 9.1 CORO1A CS EEA1 HSPD1 HSPE1 HTRA1

Biological processes related to Bartonellosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.16 HSPD1 HSPE1
2 response to unfolded protein GO:0006986 8.96 HSPD1 HSPE1
3 positive regulation of T cell activation GO:0050870 8.62 CORO1A HSPD1

Molecular functions related to Bartonellosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chaperone binding GO:0051087 8.62 HSPD1 HSPE1
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Sources for Bartonellosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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