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MCID: BRT043
MIFTS: 39

Bartonellosis

Categories: Infectious diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Bartonellosis

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MalaCards integrated aliases for Bartonellosis:

Name: Bartonellosis 12 15 17
Bartonella Infections 45 74
Bartonella Infectious Disease 12
Rochalimaea Infection 12
Bartonelliasis 12

Classifications:

MalaCards categories:
Global: Infectious diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:11102
ICD9CM 36 088.0
MeSH 45 D001474
NCIt 51 C84586
SNOMED-CT 69 17116008
ICD10 34 A44 A44.9
UMLS 74 C0004771
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Summaries for Bartonellosis

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Disease Ontology : 12 A primary bacterial infectious disease that is caused by the bacteria of the genus Bartonella.

MalaCards based summary : Bartonellosis, also known as bartonella infections, is related to cat-scratch disease and carrion's disease. An important gene associated with Bartonellosis is HTRA1 (HtrA Serine Peptidase 1), and among its related pathways/superpathways is Mitochondrial protein import. The drugs Prednisone and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and bone, and related phenotypes are Decreased viability with cisplatin and Reduced mammosphere formation

Wikipedia : 77 Bartonellosis is an infectious disease produced by bacteria of the genus Bartonella.Bartonella species... more...

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Related Diseases for Bartonellosis

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Diseases related to Bartonellosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 cat-scratch disease 32.5 CS EEA1 HSPD1 HTRA1
2 carrion's disease 32.4 ASXL3 HSPD1 HSPE1
3 bacillary angiomatosis 31.2 ATR HSPE1 SLC35G5 STAB1
4 trench fever 11.4
5 neuroretinitis 10.2
6 sarcoma 10.2
7 lyme disease 10.2
8 babesiosis 10.2
9 endocarditis 10.1
10 kaposi sarcoma 10.1
11 ehrlichiosis 10.1
12 plague 10.1
13 human granulocytic anaplasmosis 10.0 ATR HSPD1
14 infective endocarditis 10.0
15 sleeping sickness 10.0
16 granulomatous hepatitis 10.0
17 chronic kidney failure 9.9
18 hemolytic anemia 9.9
19 hepatitis 9.9
20 thrombocytopenia 9.9
21 salmonellosis 9.9
22 uveitis 9.9
23 hyperinsulinemic hypoglycemia 9.9
24 leptospirosis 9.9
25 kidney disease 9.9
26 macular holes 9.9
27 leishmaniasis 9.9
28 iridocyclitis 9.9
29 yellow fever 9.9
30 hypoglycemia 9.9
31 anterior uveitis 9.9
32 xp22.3 microdeletion syndrome 9.9
33 sennetsu fever 9.9 HSPD1 HSPE1
34 chancroid 9.9 HSPD1 HSPE1
35 leukodystrophy, hypomyelinating, 4 9.8 HSPD1 HSPE1
36 rheumatoid arthritis 9.8
37 arthritis 9.8
38 granuloma annulare 9.8
39 q fever 9.8
40 panniculitis 9.8
41 panic disorder 9.8
42 juvenile rheumatoid arthritis 9.8
43 meningitis 9.8
44 pyogenic granuloma 9.8
45 depression 9.8
46 leprosy 3 9.8 HSPD1 HSPE1
47 testicular disease 9.7 HSPD1 HSPE1
48 mycobacterium tuberculosis 1 9.6 HSPD1 HSPE1

Graphical network of the top 20 diseases related to Bartonellosis:



Diseases related to Bartonellosis
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Symptoms & Phenotypes for Bartonellosis

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GenomeRNAi Phenotypes related to Bartonellosis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with cisplatin GR00101-A-4 8.96 ASXL3 ATR
2 Reduced mammosphere formation GR00396-S 8.92 ATR CS HSPD1 HSPE1
Sources

Drugs & Therapeutics for Bartonellosis

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Drugs for Bartonellosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
2
Azithromycin Approved Phase 4,Phase 3 83905-01-5 447043 55185
3
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
4
Nevirapine Approved Phase 4 129618-40-2 4463
5
Ritonavir Approved, Investigational Phase 4,Phase 3 155213-67-5 392622
6
Tenofovir Approved, Experimental, Investigational Phase 4 147127-20-6 464205
7 Hormones Phase 4
8 Antineoplastic Agents, Hormonal Phase 4
9 glucocorticoids Phase 4
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
11 Hormone Antagonists Phase 4
12 Anti-Inflammatory Agents Phase 4
13
protease inhibitors Phase 4,Phase 3
14 Cytochrome P-450 Enzyme Inhibitors Phase 4
15 Antiviral Agents Phase 4,Phase 3
16 HIV Protease Inhibitors Phase 4,Phase 3
17 Atazanavir Sulfate Phase 4
18 Reverse Transcriptase Inhibitors Phase 4
19 Anti-HIV Agents Phase 4,Phase 3
20 Anti-Retroviral Agents Phase 4,Phase 3
21 Cytochrome P-450 CYP3A Inhibitors Phase 4
22 Anti-Infective Agents Phase 4,Phase 3
23 Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Phase 4
24 Cytochrome P-450 CYP3A Inducers Phase 4
25 Nucleic Acid Synthesis Inhibitors Phase 4
26
Benzocaine Approved, Investigational Phase 3 1994-09-7, 94-09-7 2337
27
tannic acid Approved Phase 3 1401-55-4
28
Aldesleukin Approved Phase 3 110942-02-4, 85898-30-2
29
Maraviroc Approved, Investigational Phase 3 376348-65-1 3002977
30
Fosamprenavir Approved Phase 3 226700-79-4 131536
31
Efavirenz Approved, Investigational Phase 3 154598-52-4 64139
32 Analgesics, Non-Narcotic Phase 3
33 Peripheral Nervous System Agents Phase 3
34 Interleukin-2 Phase 3
35 Analgesics Phase 3
36 Gentamicins Phase 3
37 Anti-Bacterial Agents Phase 3
38 Immunoglobulins
39 Antibodies
40 Liver Extracts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease Unknown status NCT01469702 Phase 4 prednison and azithromycin;prednison, azithromycin;prednison, Azenil
2 Nevirapine vs. Atazanavir Boosted With Ritonavir on a Background of Truvada in Human Immunodeficiency Virus (HIV) Infected Naive Patients (NEwArT) Completed NCT00552240 Phase 4 tenofovir DF 300 mg QD;tenofovir DF 300 mg QD;emtricitabine 200 mg QD;emtricitabine 200 mg QD;Nevirapine 200 mg BID;Atazanavir 300 mg;Ritonavir 100 mg
3 Interleukin-2 Plus Antiretroviral Therapy for HIV-Infected Patients With Low CD4+ Counts (SILCAAT Study) Completed NCT00013611 Phase 3 Proleukin
4 An International Study to Evaluate Recombinant Interleukin-2 in HIV Positive Patients Taking Anti-retroviral Therapy Completed NCT00004978 Phase 3 Recombinant interleukin-2 (rIL-2)
5 Immuno-stimulation With Maraviroc Combined to Antiretroviral Therapy in Advanced Late Diagnosed HIV-1 Infected Patients Completed NCT01348308 Phase 3 Maraviroc (Celsentri);Placebo
6 Intra-nodal Injection of Gentamicin for the Treatment of Suppurated Cat Scratch Disease's Lymphadenitis Recruiting NCT03132116 Phase 3 gentamicin;placebo
7 Bartonella in Liver Transplant Patients Recruiting NCT02595710

Search NIH Clinical Center for Bartonellosis

Cochrane evidence based reviews: bartonella infections

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Genetic Tests for Bartonellosis

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Anatomical Context for Bartonellosis

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MalaCards organs/tissues related to Bartonellosis:

42
Liver, Kidney, Bone, Skin, Testes, Endothelial, Bone Marrow
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Publications for Bartonellosis

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Articles related to Bartonellosis:

(show top 50) (show all 135)
# Title Authors Year
1
False Negative Results in Bartonellosis Diagnosis. ( 30730266 )
2019
2
Multimodality imaging of multifocal ocular bartonellosis with an optic nerve head mass. ( 30851793 )
2019
3
Human Bartonellosis: An Underappreciated Public Health Problem? ( 31010191 )
2019
4
Ocular manifestations of bartonellosis. ( 30124532 )
2018
5
Evaluation of cell culture-grown Bartonella antigens in immunofluorescent antibody assays for the serological diagnosis of bartonellosis in dogs. ( 30307643 )
2018
6
Feline bartonellosis key issues and possible vectors ( 30720968 )
2018
7
Bartonella infections in humans dogs and cats. ( 29631316 )
2018
8
Bartonella infections in three species of Microtus: prevalence and genetic diversity, vertical transmission and the effect of concurrent Babesia microti infection on its success. ( 30165879 )
2018
9
Bartonella infections in cats and dogs including zoonotic aspects. ( 30514361 )
2018
10
Bartonellosis, One Health and all creatures great and small. ( 28133871 )
2017
11
Clinical Profile and Visual Outcome of Ocular Bartonellosis in Malaysia. ( 28265290 )
2017
12
Acute Unilateral Vision Loss in a Female Adolescent Due to Ocular Bartonellosis. ( 28398939 )
2017
13
Ocular Bartonellosis. ( 28778273 )
2017
14
Bartonellosis in Chronic Kidney Disease: An Unrecognized and Unsuspected Diagnosis. ( 28884961 )
2017
15
Ultrasound imaging as the basis of a clinical diagnosis of systemic bartonellosis in a patient after bone marrow transplantation. A case report. ( 27446604 )
2016
16
Role of Whole-Body MR with DWIBS in child's Bartonellosis. ( 27598022 )
2016
17
Clinical determinants of Lyme borreliosis, babesiosis, bartonellosis, anaplasmosis, and ehrlichiosis in an Australian cohort. ( 25565883 )
2015
18
Neuroretinitis in ocular bartonellosis. ( 25453244 )
2015
19
Ocular bartonellosis in transplant recipients: two case reports and review of the literature. ( 26146758 )
2015
20
Paleomicrobiology of Bartonella infections. ( 26369716 )
2015
21
Hyperinsulinemic hypoglycemia syndrome in 2 dogs with bartonellosis. ( 24934703 )
2014
22
Bartonellosis: one health perspectives for an emerging infectious disease. ( 24936029 )
2014
23
Neuroretinitis in ocular bartonellosis: a case series. ( 25120352 )
2014
24
Risk factors for human lice and bartonellosis among the homeless, San Francisco, California, USA. ( 25280380 )
2014
25
Pathogenicity and treatment of Bartonella infections. ( 24933445 )
2014
26
Treatment outcomes of human bartonellosis: a systematic review and meta-analysis. ( 23602630 )
2013
27
Macular hole: a rare complication of ocular bartonellosis. ( 23681239 )
2013
28
Cat scratch disease and other Bartonella infections. ( 23654065 )
2013
29
Bartonella infections in deer keds (Lipoptena cervi) and moose (Alces alces) in Norway. ( 23104416 )
2013
30
Global distribution of Bartonella infections in domestic bovine and characterization of Bartonella bovis strains using multi-locus sequence typing. ( 24278342 )
2013
31
Paradoxical response in ocular bartonellosis. ( 22057809 )
2012
32
Cryptogenic hepatitis and bartonellosis. ( 22307338 )
2012
33
Feline bartonellosis: we're just scratching the surface. ( 22918842 )
2012
34
Chronic Bartonellosis in cats: what are the potential implications? ( 22918844 )
2012
35
Bartonella and Bartonella infections in China: from the clinic to the laboratory. ( 22304899 )
2012
36
Differences in the ecology of Bartonella infections of Apodemus flavicollis and Myodes glareolus in a boreal forest. ( 22336264 )
2012
37
Emerging incidence of Lyme borreliosis, babesiosis, bartonellosis, and granulocytic ehrlichiosis in Australia. ( 22267937 )
2011
38
Bartonellosis in cats: a role in uveitis? ( 21923819 )
2011
39
The pathophysiology of the acute phase of human bartonellosis resembles AIDS. ( 19665314 )
2010
40
Bartonellosis. ( 20018462 )
2010
41
Bartonellosis, an increasingly recognized zoonosis. ( 20148999 )
2010
42
Inoculation bartonellosis in an adult: a case report. ( 20184210 )
2010
43
Flea-associated zoonotic diseases of cats in the USA: bartonellosis, flea-borne rickettsioses, and plague. ( 20185369 )
2010
44
Disseminated bartonellosis presenting as neuroretinitis in a young adult with human immunodeficiency virus infection. ( 20216243 )
2010
45
Bartonellosis: an emerging infectious disease of zoonotic importance to animals and human beings. ( 20230432 )
2010
46
Bartonellosis diagnosis requires careful evaluation. ( 20835501 )
2010
47
Feline bartonellosis. ( 20933137 )
2010
48
Identification of Bartonella infections in febrile human patients from Thailand and their potential animal reservoirs. ( 20519614 )
2010
49
Bartonellosis causing bilateral Leber neuroretinitis: a case report. ( 19253255 )
2009
50
Ocular bartonellosis. ( 19319232 )
2009
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Variations for Bartonellosis

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Expression for Bartonellosis

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Search GEO for disease gene expression data for Bartonellosis.
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Pathways for Bartonellosis

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Pathways related to Bartonellosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Mitochondrial protein import 67
10.42 CS HSPD1
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GO Terms for Bartonellosis

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Cellular components related to Bartonellosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.35 CS EEA1 HSPD1 HSPE1 HTRA1
2 mitochondrial matrix GO:0005759 8.8 CS HSPD1 HSPE1

Biological processes related to Bartonellosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 8.96 HSPD1 HSPE1
2 response to unfolded protein GO:0006986 8.62 HSPD1 HSPE1

Molecular functions related to Bartonellosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chaperone binding GO:0051087 8.62 HSPD1 HSPE1
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Sources for Bartonellosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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