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MCID: BSL011
MIFTS: 33

Basal Cell Carcinoma, Multiple

Categories: Cancer diseases, Genetic diseases, Rare diseases, Respiratory diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Basal Cell Carcinoma, Multiple

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MalaCards integrated aliases for Basal Cell Carcinoma, Multiple:

Name: Basal Cell Carcinoma, Multiple 54 30 56 74
Multiple Basal Cell Carcinoma 54

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases Genetic diseases
Anatomical: Skin diseases Respiratory diseases
See all MalaCards categories (disease lists)


External Ids:

UMLS 74 C1854245
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Summaries for Basal Cell Carcinoma, Multiple

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MalaCards based summary : Basal Cell Carcinoma, Multiple, also known as multiple basal cell carcinoma, is related to bazex syndrome and basal cell carcinoma 1. An important gene associated with Basal Cell Carcinoma, Multiple is PTCH1 (Patched 1), and among its related pathways/superpathways are Pathways in cancer and Presynaptic function of Kainate receptors. The drugs Verteporfin and Veratrum Alkaloids have been mentioned in the context of this disorder. Affiliated tissues include skin and bone, and related phenotypes are no phenotypic analysis and normal

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Related Diseases for Basal Cell Carcinoma, Multiple

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Diseases in the Small Cell Carcinoma family:

Basal Cell Carcinoma 1 Basal Cell Carcinoma 2
Basal Cell Carcinoma 3 Basal Cell Carcinoma 4
Basal Cell Carcinoma 5 Basal Cell Carcinoma 6
Basal Cell Carcinoma 7 Basal Cell Carcinoma
Large Cell Carcinoma Basal Cell Carcinoma, Multiple

Diseases related to Basal Cell Carcinoma, Multiple via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 bazex syndrome 11.7
2 basal cell carcinoma 1 11.6
3 basal cell nevus syndrome 11.5
4 multiple familial trichoepithelioma 11.2
5 basal cell carcinoma 10.3
6 tinea capitis 10.1
7 myotonic dystrophy 10.1
8 myotonia atrophica 10.1
9 myotonic dystrophy 1 10.0
10 nevus, epidermal 10.0
11 xeroderma pigmentosum, variant type 10.0
12 focal dermal hypoplasia 10.0
13 hypotrichosis 10.0
14 phacomatosis pigmentokeratotica 10.0
15 phakomatosis pigmentokeratotica 10.0
16 pheochromocytoma 9.8
17 congenital heart defects, hamartomas of tongue, and polysyndactyly 9.8
18 cartilage-hair hypoplasia 9.8
19 mycosis fungoides 9.8
20 brooke-spiegler syndrome 9.8
21 nevus comedonicus 9.8
22 acute lymphocytic leukemia 9.8
23 burn scar 9.8
24 leukemia 9.8
25 lymphedema 9.8
26 oculocutaneous albinism 9.8
27 lymphocytic leukemia 9.8
28 rickets 9.8
29 erysipelas 9.8
30 lymphadenitis 9.8
31 keratoacanthoma 9.8
32 merkel cell carcinoma 9.8
33 spindle cell carcinoma 9.8
34 superficial basal cell carcinoma 9.8
35 vulva basal cell carcinoma 9.8
36 human immunodeficiency virus infectious disease 9.8
37 eccrine acrospiroma 9.8
38 learning disability 9.8
39 albinism 9.8
40 inflammatory linear verrucous epidermal nevus 9.8
41 9q22.3 microdeletion 9.8
42 light and heavy chain deposition disease 9.8
43 nodular basal cell carcinoma 9.6 PTCH1 WNT3
44 squamous cell carcinoma 9.5 CYP1A1 PTCH1

Graphical network of the top 20 diseases related to Basal Cell Carcinoma, Multiple:



Diseases related to Basal Cell Carcinoma, Multiple
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Symptoms & Phenotypes for Basal Cell Carcinoma, Multiple

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MGI Mouse Phenotypes related to Basal Cell Carcinoma, Multiple:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 no phenotypic analysis MP:0003012 9.13 CYP1A1 PTCH1 WNT3
2 normal MP:0002873 8.8 CYP1A1 PTCH1 WNT3
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Drugs & Therapeutics for Basal Cell Carcinoma, Multiple

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Drugs for Basal Cell Carcinoma, Multiple (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 86)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Verteporfin Approved, Investigational Phase 3 129497-78-5
2 Veratrum Alkaloids Phase 3,Phase 2
3 Antihypertensive Agents Phase 3,Phase 2
4 Dermatologic Agents Phase 3,Phase 2,Not Applicable
5 Photosensitizing Agents Phase 3,Phase 2,Not Applicable
6
Aminolevulinic acid Approved Phase 2,Phase 1,Not Applicable 106-60-5 137
7
Nicotinamide Approved, Investigational Phase 2 98-92-0 936
8
Tazarotene Approved, Investigational Phase 2 118292-40-3 5381
9
Celecoxib Approved, Investigational Phase 2 169590-42-5 2662
10
Fluorouracil Approved Phase 1, Phase 2 51-21-8 3385
11
Miconazole Approved, Investigational, Vet_approved Phase 2,Phase 1 22916-47-8 4189
12
Itraconazole Approved, Investigational Phase 2 84625-61-6 55283
13
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
14
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
15
Cyclophosphamide Approved, Investigational Phase 2 6055-19-2, 50-18-0 2907
16
Carboplatin Approved Phase 2 41575-94-4 38904 10339178 498142
17
Etoposide Approved Phase 2 33419-42-0 36462
18
leucovorin Approved Phase 2 58-05-9 6006 143
19
Ipilimumab Approved Phase 2 477202-00-9
20
nivolumab Approved Phase 2 946414-94-4
21
Niacin Approved, Investigational, Nutraceutical Phase 2 59-67-6 938
22
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
23
Emodepside Investigational, Vet_approved Phase 2 155030-63-0
24 Pharmaceutical Solutions Phase 2,Not Applicable
25 Nutrients Phase 2,Phase 1,Not Applicable
26 Vitamin B Complex Phase 2
27 Nicotinic Acids Phase 2
28 Trace Elements Phase 2,Phase 1,Not Applicable
29 Vitamins Phase 2,Phase 1,Not Applicable
30 Vitamin B3 Phase 2
31 Keratolytic Agents Phase 2
32 Micronutrients Phase 2,Phase 1,Not Applicable
33 Vitamin B9 Phase 2
34 Folate Phase 2
35 Cyclooxygenase Inhibitors Phase 2
36 Anti-Inflammatory Agents, Non-Steroidal Phase 2
37 Cyclooxygenase 2 Inhibitors Phase 2
38 Anti-Inflammatory Agents Phase 2
39 Peripheral Nervous System Agents Phase 2
40 Analgesics, Non-Narcotic Phase 2
41 Antirheumatic Agents Phase 2
42 Analgesics Phase 2
43 Interferon-gamma Phase 1, Phase 2,Phase 2
44 interferons Phase 1, Phase 2
45 Antifungal Agents Phase 2,Phase 1
46 Anti-Infective Agents Phase 2,Phase 1
47 Immunosuppressive Agents Phase 2,Phase 1
48 Immunologic Factors Phase 2,Phase 1
49 Hormones Phase 2,Phase 1,Not Applicable
50 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2

Interventional clinical trials:

(show all 33)
# Name Status NCT ID Phase Drugs
1 Study of Patidegib Topical Gel, 2%, for the Reduction of Disease Burden of Persistently Developing Basal Cell Carcinomas (BCCs) in Subjects With Basal Cell Nevus Syndrome Recruiting NCT03703310 Phase 3 Patidegib Topical Gel, 2%;Patidegib Topical Gel, Vehicle
2 Two Studies to Determine if Verteporfin PDT is Effective & Safe in Treating Multiple Basal Cell Carcinoma of the Skin. Terminated NCT00049959 Phase 3 verteporfin PDT
3 Efficacy, Safety and Tolerability of Topically Applied LDE225 Cream (Hedgehog Pathway Inhibitor) in Adult Patients With Nevoid Basal Cell Carcinoma Syndrome (NBCCS) Withdrawn NCT03070691 Phase 2, Phase 3 LDE225B;Vehicle
4 A Study of Two Vismodegib Regimens in Participants With Multiple Basal Cell Carcinomas Completed NCT01815840 Phase 2 Vismodegib;Placebo
5 Trial Comparing the Effects of Intermittent Vismodegib vs. PDT in Patients With Multiple Basal Cell Carcinomas Completed NCT01556009 Phase 2 Vismodegib;Aminolevulinic acid %20 topical solution
6 Trial of Patidegib Gel 2%, 4%, and Vehicle to Decrease the Number of Surgically Eligible Basal Cell Carcinomas (BCC) in Gorlin Syndrome Patients Completed NCT02762084 Phase 2 patidegib;vehicle gel
7 A Trial to Evaluate the Safety, Local Tolerability, Pharmacokinetics and Pharmacodynamics of LDE225 on Skin Basal Cell Carcinomas in Gorlin Syndrome Patients Completed NCT00961896 Phase 2 Vehicle;LDE225 0.25%;LDE225 0.75%
8 Topical Tazarotene in Treating Patients With Basal Cell Skin Cancer and Basal Cell Nevus Syndrome on the Chest and Back Completed NCT00783965 Phase 2 tazarotene
9 To Determine The Efficacy and Safety of GDC-0449 in Patients With Basal Cell Nevus Syndrome (BCNS) Completed NCT00957229 Phase 2 GDC-0449
10 Topical Tazarotene in Treating Patients With Basal Cell Skin Cancer and Basal Cell Nevus Syndrome on the Face Completed NCT00489086 Phase 2 tazarotene
11 Efficacy, Safety and Pharmacokinetics of Oral LDE225 in Treatment of Patients With Nevoid Basal Cell Carcinoma Syndrome (NBCCS) Completed NCT01350115 Phase 2 LDE225;Placebo
12 Celecoxib in Preventing Basal Cell Carcinoma in Patients With Basal Cell Nevus Syndrome Completed NCT00023621 Phase 2 celecoxib
13 A Study of the Efficacy and Safety of ASN-002 in Adult Patients With Low-risk Nodular Basal Cell Carcinoma Completed NCT02550678 Phase 1, Phase 2 5-FU
14 Clinical Trial of Patidegib Gel 2%, 4%, and Vehicle Applied Once or Twice Daily to Decrease the GLI1 Biomarker in Sporadic Nodular Basal Cell Carcinomas Completed NCT02828111 Phase 2 Patidegib;Vehicle gel
15 Open-label Trial of SUBAâ„¢-Itraconazole (SUBA-Cap) in Subjects With Basal Cell Carcinoma Nevus Syndrome (BCCNS) Active, not recruiting NCT02354261 Phase 2 SUBA-Itraconazole
16 Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed, Non-metastatic Desmoplastic Medulloblastoma Active, not recruiting NCT02017964 Phase 2 Carboplatin;Cyclophosphamide;Etoposide;Methotrexate;Vincristine Sulfate
17 Nivolumab With Vismodegib in Patients With Basal Cell Nevus Syndrome Not yet recruiting NCT03767439 Phase 2 Vismodegib;Nivolumab;Ipilimumab
18 Study of ASN-002 to Treat Basal Cell Carcinomas (BCCs) in Individuals With Basal Cell Nevus Syndrome (BCNS) Suspended NCT03208296 Phase 1, Phase 2
19 Pilot Study of Sonidegib and Buparlisib in Treating Patients With Advanced or Metastatic Basal Cell Carcinoma Terminated NCT02303041 Phase 2 Buparlisib;Sonidegib
20 Photodynamic Therapy and Vismodegib for Multiple Basal Cell Carcinomas Completed NCT02639117 Phase 1 Vismodegib
21 Topical Sirolimus in Patients With Basal Cell Nevus Syndrome and in Healthy Participants Completed NCT00433485 Phase 1 sirolimus
22 Development of a Nanosecond Pulsed Electric Field System to Treat Skin Cancer Completed NCT01463709 Phase 1
23 Vitamin D and Photodynamic Therapy for Treatment of BCC in BCNS Recruiting NCT03483441 Phase 1 PDT
24 The Evaluation of Oral Acitretin in the Treatment of Psoriasis, Cutaneous Disorders of Keratinization, Multiple Basal Cell Carcinomas and Other Retinoid Responsive Diseases Completed NCT00005660
25 Blue vs Red Light During Levulan Based Photodynamic Therapy in Patients With Basal Cell Nevus Syndrome Completed NCT02157623 Not Applicable Levulan
26 Study of BMS-833923 in Two Specific Patients With Basal Cell Nevus Syndrome Completed NCT02100371 Not Applicable BMS-833923
27 Use of an SPF30 Sunscreen and an After-sun-lotion in Skin Cancer Risk Patients Completed NCT00555633
28 Isotretinoin in Preventing Skin Cancer Completed NCT00025012 Not Applicable isotretinoin
29 Levocarnitine in Treating Patients With Vismodegib-Associated Muscle Spasms Completed NCT01893892 Not Applicable
30 A Clinical Trial of Dermacorder for Detecting Malignant Skin Lesions Completed NCT01014819
31 Vitamin D as a Nutritional Neoadjuvant During Photodynamic Therapy of Basal Cell Carcinoma Recruiting NCT03467789 Not Applicable
32 Familial Investigations of Childhood Cancer Predisposition Recruiting NCT03050268
33 A Study to Assess the Effectiveness and Safety of Vismodegib (Erivedge®) in Participants With Advanced Basal Cell Carcinoma (BCC) Active, not recruiting NCT02371967 Vismodegib

Search NIH Clinical Center for Basal Cell Carcinoma, Multiple

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Genetic Tests for Basal Cell Carcinoma, Multiple

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Genetic tests related to Basal Cell Carcinoma, Multiple:

# Genetic test Affiliating Genes
1 Basal Cell Carcinoma, Multiple 30
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Anatomical Context for Basal Cell Carcinoma, Multiple

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MalaCards organs/tissues related to Basal Cell Carcinoma, Multiple:

42
Skin, Bone
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Publications for Basal Cell Carcinoma, Multiple

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Articles related to Basal Cell Carcinoma, Multiple:

(show all 21)
# Title Authors Year
1
Multiple Basal Cell Carcinoma Arising in a Verrucous Epidermal Naevus: Clinical, Histological and Therapeutic Observations. ( 28759100 )
2018
2
Correlates of multiple basal cell carcinoma in a retrospective cohort study: Sex, histologic subtypes, and anatomic distribution. ( 28392289 )
2017
3
Familial Multiple Basal Cell Carcinoma (Gorlin's Syndrome): A Case Report of a Father and Son. ( 24249904 )
2013
4
Simultaneous treatment of multiple basal cell carcinoma lesions. ( 19029050 )
2008
5
Long-term toxic effects of radiations: sarcomatoid carcinoma and multiple basal cell carcinoma of the limbs in chronic radiodermatitis. ( 15803869 )
2005
6
Onset of multiple basal cell carcinoma 60 years after X-ray treatment for tinea capitis. ( 15096161 )
2004
7
Merkel cell carcinoma and multiple basal cell carcinoma in an African albino woman with HIV infection. ( 15544700 )
2004
8
Nonsyndromic type of hereditary multiple basal cell carcinoma. ( 11078568 )
2000
9
Multiple basal cell carcinoma. A clinical evaluation of risk factors. ( 9534891 )
1998
10
Multiple basal cell carcinoma developing two years after 60Co irradiation. ( 9649688 )
1998
11
Truncal tumor site is associated with high risk of multiple basal cell carcinoma and is influenced by glutathione S-transferase, GSTT1, and cytochrome P450, CYP1A1 genotypes, and their interaction. ( 9077484 )
1997
12
Three cases of multiple basal cell carcinoma arising in port-wine stains previously treated with thorium X. ( 8977700 )
1996
13
Multiple basal cell carcinoma associated with keratoacanthoma. ( 1292252 )
1992
14
Multiple basal cell carcinoma in tropical Australia. ( 1459761 )
1992
15
Benzo(a)pyrene metabolism, DNA-binding and UV-induced repair of DNA damage in cultured skin fibroblasts from a patient with unilateral multiple basal cell carcinoma. ( 2923792 )
1989
16
Multiple basal-cell carcinoma of the vulva. ( 6747076 )
1984
17
Decreased lymphocyte blastogenic responses in patients with multiple basal cell carcinoma. ( 7240477 )
1981
18
Multiple basal cell carcinoma 58 years after X-ray therapy. ( 507882 )
1979
19
Multiple basal cell carcinoma and internal malignant tumors. ( 1130803 )
1975
20
Multiple basal cell carcinoma in a 24-year-old man. ( 5641342 )
1968
21
Unusual case of multiple basal cell carcinoma with metastasis to the parotid lymph gland. ( 5673242 )
1968
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Variations for Basal Cell Carcinoma, Multiple

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Expression for Basal Cell Carcinoma, Multiple

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Search GEO for disease gene expression data for Basal Cell Carcinoma, Multiple.
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Pathways for Basal Cell Carcinoma, Multiple

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Pathways related to Basal Cell Carcinoma, Multiple according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Pathways in cancer 38
11.98 PTCH1 WNT3
2
Presynaptic function of Kainate receptors 67
Show member pathways
 11.56 PTCH1 WNT3
3
Proteoglycans in cancer 38
11.26 PTCH1 WNT3
4
Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling 66
Show member pathways
 11.11 PTCH1 WNT3
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GO Terms for Basal Cell Carcinoma, Multiple

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Cellular components related to Basal Cell Carcinoma, Multiple according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endocytic vesicle membrane GO:0030666 8.62 PTCH1 WNT3

Biological processes related to Basal Cell Carcinoma, Multiple according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 8.96 CYP1A1 PTCH1
2 response to organic cyclic compound GO:0014070 8.62 CYP1A1 PTCH1
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Sources for Basal Cell Carcinoma, Multiple

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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