Basal Cell Carcinoma, Multiple disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Basal Cell Carcinoma, Multiple

MalaCards integrated aliases for Basal Cell Carcinoma, Multiple:

Name: Basal Cell Carcinoma, Multiple ⁵³ ²⁹ ⁵⁵ ⁷³

Multiple Basal Cell Carcinoma ⁵³

Classifications:

MalaCards categories:
Global: Rare diseases Genetic diseases Cancer diseases
Anatomical: Skin diseases Respiratory diseases

See all MalaCards categories (disease lists)

External Ids:

UMLS ⁷³ C1854245

Sources

Summaries for Basal Cell Carcinoma, Multiple

MalaCards based summary : Basal Cell Carcinoma, Multiple, also known as multiple basal cell carcinoma, is related to basal cell nevus syndrome and basal cell carcinoma. An important gene associated with Basal Cell Carcinoma, Multiple is PTCH1 (Patched 1), and among its related pathways/superpathways are G-Beta Gamma Signaling and Pathways in cancer. The drugs Verteporfin and Photosensitizing Agents have been mentioned in the context of this disorder. Affiliated tissues include skin and bone, and related phenotypes are Increased viability and cardiovascular system

Sources

Related Diseases for Basal Cell Carcinoma, Multiple

Diseases in the Small Cell Carcinoma family:

Basal Cell Carcinoma 1	Basal Cell Carcinoma 2
Basal Cell Carcinoma 3	Basal Cell Carcinoma 4
Basal Cell Carcinoma 5	Basal Cell Carcinoma 6
Basal Cell Carcinoma 7	Cell Type Benign Neoplasm
Basal Cell Carcinoma	Large Cell Carcinoma
Basal Cell Carcinoma, Multiple

Diseases related to Basal Cell Carcinoma, Multiple via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)

#	Related Disease	Score	Top Affiliating Genes
1	basal cell nevus syndrome	31.7	PTCH1 PTCH2 SMO
2	basal cell carcinoma	29.1	CYP1A1 PTCH1 PTCH2 RASA1 SMO
3	bazex syndrome	11.6
4	basal cell carcinoma 1	11.6
5	multiple familial trichoepithelioma	11.2
6	tinea capitis	10.1
7	nevus, epidermal	10.0
8	xeroderma pigmentosum, variant type	10.0
9	focal dermal hypoplasia	10.0
10	hypotrichosis	10.0
11	phacomatosis pigmentokeratotica	10.0
12	phakomatosis pigmentokeratotica	10.0
13	albinism, oculocutaneous, type v	9.9	PTCH2 SLC45A2
14	albinism, oculocutaneous, type vii	9.9	PTCH2 SLC45A2
15	keratocystic odontogenic tumor	9.8	PTCH1 SMO
16	myotonic dystrophy 1	9.8
17	pheochromocytoma	9.8
18	cartilage-hair hypoplasia	9.8
19	brooke-spiegler syndrome	9.8
20	nevus comedonicus	9.8
21	acute lymphocytic leukemia	9.8
22	burn scar	9.8
23	lymphedema	9.8
24	oculocutaneous albinism	9.8
25	lymphocytic leukemia	9.8
26	rickets	9.8
27	hypohidrosis	9.8
28	erysipelas	9.8
29	lymphadenitis	9.8
30	keratoacanthoma	9.8
31	merkel cell carcinoma	9.8
32	superficial basal cell carcinoma	9.8
33	vulva basal cell carcinoma	9.8
34	human immunodeficiency virus infectious disease	9.8
35	learning disability	9.8
36	albinism	9.8
37	myotonic dystrophy	9.8
38	inflammatory linear verrucous epidermal nevus	9.8
39	myotonia atrophica	9.8
40	9q22.3 microdeletion	9.8
41	ameloblastoma	9.8	PTCH1 SMO
42	medulloblastoma	9.5	PTCH1 PTCH2 SMO

Graphical network of the top 20 diseases related to Basal Cell Carcinoma, Multiple:

Sources

Symptoms & Phenotypes for Basal Cell Carcinoma, Multiple

GenomeRNAi Phenotypes related to Basal Cell Carcinoma, Multiple according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased viability	GR00386-A-1	9.1	CYP1A1 PTCH1 PTCH2 RASA1 SLC45A2 SMO

MGI Mouse Phenotypes related to Basal Cell Carcinoma, Multiple:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	9.55	CYP1A1 PTCH1 PTCH2 RASA1 SMO
2	digestive/alimentary	MP:0005381	9.26	PTCH1 PTCH2 RASA1 SMO
3	muscle	MP:0005369	8.92	PTCH1 PTCH2 RASA1 SMO

Sources

Drugs & Therapeutics for Basal Cell Carcinoma, Multiple

Drugs for Basal Cell Carcinoma, Multiple (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Verteporfin

Approved, Investigational

Phase 3

129497-78-5

2

Photosensitizing Agents

Phase 3,Phase 2

3

Dermatologic Agents

Phase 3,Phase 2

4

Aminolevulinic acid

Approved

Phase 2,Phase 1

106-60-5

137

Synonyms:

106-60-5

35BEC718-C970-426A-9859-BF58284C60B4

5 Aminolaevulinate

5 Aminolevulinate

5451-09-2

5-ALA

5-amino-4-oxo-Pentanoate

5-amino-4-Oxopentanoate

5-Amino-4-oxopentanoate

5-amino-4-oxo-Pentanoic acid

5-amino-4-Oxopentanoic acid

5-Amino-4-oxopentanoic acid

5-amino-4-Oxovalerate

5-amino-4-Oxovaleric acid

5-Amino-4-oxovaleric acid

5-Aminolaevulinate

5-Aminolaevulinic acid

5-amino-levulinate

5-amino-Levulinate

5-Aminolevulinate

5-amino-Levulinic acid

5-Aminolevulinic acid

AC-054

AC1L18K9

Acid hydrochloride, aminolevulinic

Acid, aminolevulinic

Acid, Delta-aminolevulinic

AKOS003587520

Aladerm

Aminolevulinate

Aminolevulinic

amino-Levulinic acid

Aminolevulinic acid

Aminolevulinic acid hydrochloride

Bertek brand OF aminolevulinic acid hydrochloride

BIDD:GT0260

BSPBio_003407

C00430

CCRIS 8958

CHEBI:17549

CHEMBL601

CID137

CPD000857229

D07567

dALA

DALA

DB00855

Delta Aminolevulinic acid

delta-ALA

delta-Aminolevulinate

delta-aminolevulinic acid

delta-Aminolevulinic acid

DivK1c_006954

EINECS 203-414-1

Hydrochloride, aminolevulinic acid

I14-10101

KBio1_001898

KBio2_002062

KBio2_004630

KBio2_007198

KBio3_002627

KBioGR_001176

KBioSS_002062

Kerastick

Levulan

Levulinic acid, 5-amino- (8CI)

LMFA01100055

LS-101793

MLS001333097

MLS001333098

MolPort-001-788-423

NCGC00178086-01

Pentanoic acid, 5-amino-4-oxo- (9CI)

SAM002589919

SMR000857229

SPBio_001843

SpecPlus_000858

Spectrum_001582

Spectrum2_001662

Spectrum3_001654

Spectrum4_000618

Spectrum5_001505

ST50819610

UNII-88755TAZ87

δ-ala

δ-ALA

δ-aminolevulinate

δ-aminolevulinic acid

5

Pharmaceutical Solutions

Phase 2

6

Vitamin D3

Approved, Nutraceutical

Phase 1,Not Applicable

67-97-0

5280795 6221

Synonyms:

()-Vitamin D3

(+)-vitamin D3

(+)-Vitamin D3

(1S,3Z)-3-[(2e)-2-[(1R,3AR,7as)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexan-1-ol

(1S,3Z)-3-[(2E)-2-[(1R,3AR,7as)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexan-1-ol

(3 beta,5Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-3-ol

(3b,5Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-3-ol

(3beta,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol

(3beta,5Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-3-ol

(3S,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol

(3β,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol

(3Β,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol

(5Z,7E)-(3S)-9,10-seco-5,7,10(19)-cholestatrien-3-ol

(5Z,7E)-(3S)-9,10-secocholesta-5,7,10(19)-trien-3-ol

(5Z,7E)-(3S)-9,10-Secocholesta-5,7,10(19)-trien-3-ol

1406-16-2

25(OH)D

47763_SUPELCO

57651-82-8

67-97-0

7-DEHYDROCHOLESTEROL

7-Dehydrocholesterol activated

7-Dehydrocholesterol, Activated

7-Dehydrocholesterol, irradiated

7-Dehydrocholestrol, activated

8024-19-9

8050-67-7

89193_FLUKA

9,10-Seco(5Z,7E)-5,7,10(19)-cholestatrien-3beta-ol

9,10-Seco(5Z,7E)-5,7,10(19)-cholestatrien-3-ol

9,10-Secocholesta-5(Z),7(E),10(19)-trien-3(.beta.)-ol

9,10-Secocholesta-5,7,10(19)-trien-3-beta-ol

AB1002422

AC-11697

AC1L1ECK

AC1L1M23

AC1LU7IZ

AC1NQXLN

AC1NR2UO

AC1NR2UR

AC1NR2UU

AC1NS4AJ

AC1NSHJX

AC1O5EOF

AC1O7GAV

AC1O7GQ3

AC1O8FEU

AC1O8PWJ

AC1OF2GI

AC1OF2GL

AC1OIEW5

AC1OIEWB

ACon1_001997

ACTIVATED

Activated 7-dehydrocholesterol

Arachitol

Bio-0845

bmse000507

BPBio1_000460

BSPBio_000418

BSPBio_002408

C05443

C1357_SIAL

C27H44O

C9756_SIGMA

C9774_SIAL

Calciol

CAS-67-97-0

CC

CCRIS 5813

CCRIS 6286

CHEBI:283119

CHEBI:28940

CHEMBL1042

CHEMBL432780

cholecalciferol

Cholecalciferol

Cholecalciferol (D3)

Cholecalciferol (JP15/USP)

Cholecalciferol [USAN:BAN:JAN]

Cholecalciferol, D3

Cholecalciferols

Cholecalciferolum

CID10000117

CID10045875

CID10340013

CID10883523

CID10894379

CID11014566

CID11025493

CID11058152

CID11463269

CID1548921

CID2735

CID5280795

CID5283710

CID5283711

CID5283712

CID5353527

CID5363362

CID6221

CID6432644

CID6604201

CID6604662

CID6708595

CID6713938

CID6992015

CID6992016

CID7067439

CID7067440

CID7251172

CID7251174

CID9821465

Colecalciferol

Colecalciferol (INN)

Colecalciferolo

Colecalciferolo [DCIT]

colecalciferolum

Colecalciferolum

Colecalciferolum [INN-Latin]

Colecalcipherol

D00188

D3-Vicotrat

D3-Vigantol

DB00169

Delsterol

Delta-D

Delta-D (TN)

Deparal

Dihydrocholesterol

DivK1c_006276

Duphafral D3 1000

Ebivit

EINECS 200-673-2

EINECS 215-797-2

EPA Pesticide Chemical Code 202901

FeraCol

HMS1569E20

HMS2092M12

HSDB 820

I05-0041

Irradiated 7-dehydrocholesterol

KBio1_001220

KBio2_001643

KBio2_004211

KBio2_006779

KBio3_001628

KBioGR_001602

KBioSS_001643

LMST03020001

LMST03020219

LMST03020220

LMST03020221

LS-1570

LS-825

LT00244775

MEGxm0_000458

Micro-dee

MolPort-001-740-051

MolPort-001-785-972

MolPort-003-666-021

MolPort-004-946-964

NCGC00016301-01

NCGC00017328-01

NCGC00091072-01

NCGC00142511-01

NCGC00159331-02

NCGC00159331-04

NCGC00178668-01

NCGC00179565-01

NCGC00179565-02

NEO Dohyfral D3

NSC 375571

NSC375571

NSC-375571

Oleovitamin D3

Prestwick_63

Prestwick0_000429

Prestwick1_000429

Prestwick2_000429

Prestwick3_000429

Provitamine

Provitina

Rampage

Ricketon

SMP1_000068

SPBio_001298

SPBio_002357

SpecPlus_000180

Spectrum_001163

Spectrum2_001369

Spectrum3_000764

Spectrum4_001201

SR-05000001559

SR-05000001559-3

ST057172

TNP00266

Trivitan

UNII-1C6V77QF41

UPCMLD-DP152

UPCMLD-DP152:001

Vi-de-3-hydrosol

Vigorsan

VITAMIN D

Vitamin D 3

vitamin d-3

Vitamin D3

Vitamin D-3

Vitamin D3 emulsifiable

VITAMIN D3 POWDER

VITAMIN_D3

Vitinc Dan-Dee-3

ZINC04474460

ZINC04492874

ZINC04492875

ZINC04492876

ZINC04492878

δ-D

7

Ergocalciferol

Approved, Nutraceutical

Phase 1,Not Applicable

50-14-6

5280793

Synonyms:

(+)-Vitamin D2

(3b,5Z,7E,22E)-9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol

(3beta,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol

(3beta,5Z,7E,22E)-9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol

(3-beta,5Z,7E,22E)-9,10-Secoergosta-5,7,10,(19),22-tetraen-3-ol

(3S,5Z,7E,14xi,17alpha,22E)-9,10-secoergosta-5,7,10,22-tetraen-3-ol

(3S,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol

(3S,5Z,7E,22E)-9,10-secoergosta-5,7,10,22-tetraen-3-ol

(3β,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol

(5E,7E,22E)-9,10-Secoergosta-5,7,10,22-tetraen-3-ol

(5Z,7E,22E)-(3S)-9,10-seco-5,7,10(19),22-ergostatetraen-3-ol

(5Z,7E,22E)-(3S)-9,10-seco-5,7,10(19),22-Ergostatetraen-3-ol

(5Z,7E,22E)-(3S)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol

(5Z,7E,22E)-(3S)-9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol

22-Tetraen 3beta 9,10,secoergosta-5,7,10(19)-ol

31316-19-5

47768_SUPELCO

4-Methylene-3-[2-[tetrahydro-7a-methyl-1-(1,4,5-trimethyl-2-hexenyl)-4(3ah)-indanylidene]ethylidene]-cyclohexanol

50-14-6

7489-18-1

7E677DC1-E1C4-4FC5-8F4A-BCE1857F7E87

8017-28-5

9,10,Secoergosta-5,7,10(19),22-tetraen 3.beta.-ol

9,10-Seco(5Z,7E,22E)-5,7,10(19),22-ergostatetraen-3-ol

9,10-Secoergosta-5,7,10(19),22-tetraen-3-beta-ol

9,10-Secoergosta-5,7,10(19),22-tetraen-3b-ol

95220_FLUKA

95220_SIGMA

AC-1355

AC1L1FIE

AC1NQXLH

AC1NS4DE

AC1NS9GI

AC1NSSVD

AC1NWAM3

AC1O5EDK

AC1O6WAM

ACon1_002187

Activated ergosterol

beta-Ol

bmse000510

BPBio1_000418

BSPBio_000380

BSPBio_001974

buco-D

Buco-D

C05441

C28H44O

Calciferol

Calciferol (TN)

Calciferol (vitamin D2)

CALCIFEROL IN A GELATIN MATRIX

CALCIFEROL, U.S.P.

Calciferols

Calciferolum

Calciferon 2

CHEBI:28934

CHEMBL1536

CID11003810

CID3249

CID5280793

CID5315257

CID5353610

CID5356615

CID5702050

CID6432478

CID6536972

component of Geltabs Vitamin D

Condacaps

Condocaps

Condol

Crtron

Crystallina

D00187

D2, Vitamin

Daral

D-Arthin

Davitamon D

Davitin

DB00153

Decaps

Dee-osterol

Dee-Osterol

Dee-ron

Dee-Ron

Dee-ronal

Dee-Ronal

Dee-roual

Dee-Roual

delta-Arthin

Deltalin

delta-Tracetten

De-rat concentrate

Deratol

Detalup

Diactol

Divit urto

Doral

Drisdol

Drisdol (TN)

D-Tracetten

E5750_SIGMA

EINECS 200-014-9

Ercalciol

ergocalciferol

Ergocalciferol

Ergocalciférol

Ergocalciferol (D2)

Ergocalciferol (JP15/USP)

Ergocalciferol [INN:BAN:JAN]

Ergocalciferol oil

Ergocalciferol: Vitamin D

Ergocalciferolo

Ergocalciferolo [DCIT]

Ergocalciferols

Ergocalciferolum

Ergocalciferolum [INN-Latin]

Ergorone

Ergosterol activated

Ergosterol irradiated

'Ergosterol irradiated'

Ergosterol, irradiated

Ertron

Fortodyl

Geltabs

Geltabs Vitamin D

Haliver

Hi-deratol

Hi-Deratol

HMS1920K20

HMS2091B19

HMS502I07

HSDB 819

Hyperkil

I05-0022

IDI1_000805

Infron

Irradiated ergosta-5,7,22-trien-3.beta.-ol

Irradiated ergosta-5,7,22-trien-3beta-ol

Irradiated ergosta-5,7,22-trien-3-beta-ol

Irradiated ergosterol

LMST03010001

LMST03010014

LS-3228

MEGxm0_000466

Metadee

Mina D2

MLS001332467

MLS001332468

MolPort-001-740-057

MolPort-001-793-930

MolPort-002-526-645

MolPort-003-666-178

MolPort-006-822-629

Mulsiferol

Mykostin

NCGC00142497-01

NCGC00179579-01

NCGC00179579-02

Novovitamin-D

NSC 62792

NSC62792

Oleovitamin D

Oleovitamin D, Synthetic

Oleovitamin D2

Osteil

Ostelin

Prestwick_554

Prestwick3_000420

Radiostol

Radstein

Radsterin

Rodine C

Rodinec

Shock-ferol

Shock-ferol sterogyl

SMR000857106

Sorex C.R

Sorex C.R.

SPECTRUM1500276

Spectrum5_000666

ST057150

Sterogyl

STOCK1N-53397

Synthetic vitamin D

Synthetic Vitamin D

UNII-VS041H42XC

Uvesterol D

Uvesterol-D

Vigantol

vio D

vio-D

Vio-D

Viostdrol

Viosterol

Viosterol in oil

Viosterol in Oil

Vitamin D 2

vitamin d-2

Vitamin D2

Vitamin- D2

VITAMIN D2

VITAMIN D2 WATER DISPERSABLE U.S.P.

Vitamin-?D2

VITAMIN_D2

Vitamina D2

Vitavel-D

WLN: L56 FYTJ A1 BY1&1U1Y1&Y1&1 FU2U- BL6YYTJ AU1 DQ

ZINC04474571

ZINC04629876

8

Vitamin D

Approved, Nutraceutical, Vet_approved

Phase 1,Not Applicable

1406-16-2

9

Vitamin D2

Phase 1,Not Applicable

10

Micronutrients

Phase 1,Not Applicable

11

Bone Density Conservation Agents

Phase 1,Not Applicable

12

Calciferol

Phase 1,Not Applicable

13

Vitamins

Phase 1,Not Applicable

14

Ergocalciferols

Phase 1,Not Applicable

15

Trace Elements

Phase 1,Not Applicable

16

Acitretin

Approved

55079-83-9

5284513 6437841

Synonyms:

(2E,4E,6E,8E)-3,7-dimethyl-9-[2,3,6-trimethyl-4-(methyloxy)phenyl]nona-2,4,6,8-tetraenoic acid

(2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid

(all-e)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid

(all-E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid

13-cis-Acitretin

13-cis-Etretin

44707_FLUKA

44707_SIGMA

54757-46-9

55079-83-9

9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid

9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid

AC1NR4LJ

AC1Q5T6I

AC-4702

Acetretin

Acitretin

Acitretin (USAN/INN)

Acitretin [USAN:INN:BAN]

Acitretin andreu brand

Acitretin roche brand

Acitretin, (Z,e,e,e)-isomer

Acitretina

Acitretina [Spanish]

Acitretine

Acitretine [French]

Acitretinum

Acitretinum [Latin]

all-trans-3,7-Dimethyl-9-(4-methoxy-2,3,6-trimethylphenyl)-2,4,6,8-nonatetraenoic acid

all-trans-Acitretin

Andreu brand OF acitretin

BIDD:GT0617

Bio-0002

CCRIS 5534

CHEBI:50173

CHEMBL1131

CID5284513

CPD000499573

D02754

EINECS 259-474-4

Etretin

FT-0082892

Hoffmann la roche brand OF acitretin

Hoffmann-la roche brand OF acitretin

HSDB 7187

Isoacitretin

Isoetretin

LS-96920

MLS001076667

MolPort-003-925-892

NCGC00163127-01

NCGC00163127-02

Neotigason

Retinoid etretin

Ro 10-1670

Ro 10-1670/000

Ro 13-7652

Ro-10-1670

Ro-10-1670/000

Ro-13-7652

Roche brand OF acitretin

S1368_Selleck

SAM002589973

SBB064171

SMR000499573

Soriatane

Soriatane (TN)

Soriatane, Acitretin

Spectrum5_002065

TMMP

U0279

UNII-LCH760E9T7

17

Keratolytic Agents

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Two Studies to Determine if Verteporfin PDT is Effective & Safe in Treating Multiple Basal Cell Carcinoma of the Skin.	Terminated	NCT00049959	Phase 3	verteporfin PDT
2	A Study of Two Vismodegib Regimens in Participants With Multiple Basal Cell Carcinomas	Completed	NCT01815840	Phase 2	Vismodegib;Placebo
3	Trial Comparing the Effects of Intermittent Vismodegib vs. PDT in Patients With Multiple Basal Cell Carcinomas	Completed	NCT01556009	Phase 2	Vismodegib;Aminolevulinic acid %20 topical solution
4	Photodynamic Therapy and Vismodegib for Multiple Basal Cell Carcinomas	Completed	NCT02639117	Phase 1	Vismodegib
5	Vitamin D and Photodynamic Therapy for Treatment of BCC in BCNS	Recruiting	NCT03483441	Phase 1	PDT
6	The Evaluation of Oral Acitretin in the Treatment of Psoriasis, Cutaneous Disorders of Keratinization, Multiple Basal Cell Carcinomas and Other Retinoid Responsive Diseases	Completed	NCT00005660
7	Vitamin D as a Nutritional Neoadjuvant During Photodynamic Therapy of Basal Cell Carcinoma	Recruiting	NCT03467789	Not Applicable

Search NIH Clinical Center for Basal Cell Carcinoma, Multiple

Sources

Genetic Tests for Basal Cell Carcinoma, Multiple

Genetic tests related to Basal Cell Carcinoma, Multiple:

#	Genetic test	Affiliating Genes
1	Basal Cell Carcinoma, Multiple ²⁹	PTCH1 PTCH2 RASA1 SMO

Sources

Anatomical Context for Basal Cell Carcinoma, Multiple

MalaCards organs/tissues related to Basal Cell Carcinoma, Multiple:

⁴¹

Skin, Bone

Sources

Publications for Basal Cell Carcinoma, Multiple

Articles related to Basal Cell Carcinoma, Multiple:

(show all 21)

#	Title	Authors	Year
1	Multiple Basal Cell Carcinoma Arising in a Verrucous Epidermal Naevus: Clinical, Histological and Therapeutic Observations. ( 28759100 )	Satolli F...Feliciani C	2018
2	Correlates of multiple basal cell carcinoma in a retrospective cohort study: Sex, histologic subtypes, and anatomic distribution. ( 28392289 )	Kuo KY...Sarin KY	2017
3	Familial Multiple Basal Cell Carcinoma (Gorlin's Syndrome): A Case Report of a Father and Son. ( 24249904 )		2013
4	Simultaneous treatment of multiple basal cell carcinoma lesions. ( 19029050 )	Montgomery L...Clark BG	2008
5	Long-term toxic effects of radiations: sarcomatoid carcinoma and multiple basal cell carcinoma of the limbs in chronic radiodermatitis. ( 15803869 )	Foti C...Angelini G	2005
6	Onset of multiple basal cell carcinoma 60 years after X-ray treatment for tinea capitis. ( 15096161 )		2004
7	Merkel cell carcinoma and multiple basal cell carcinoma in an African albino woman with HIV infection. ( 15544700 )	Colebunders R...Van Marck E	2004
8	Nonsyndromic type of hereditary multiple basal cell carcinoma. ( 11078568 )	Happle R	2000
9	Multiple basal cell carcinoma. A clinical evaluation of risk factors. ( 9534891 )	Wallberg P...Lindberg M	1998
10	Multiple basal cell carcinoma developing two years after 60Co irradiation. ( 9649688 )	Iwamoto I...Suzuki H	1998
11	Truncal tumor site is associated with high risk of multiple basal cell carcinoma and is influenced by glutathione S-transferase, GSTT1, and cytochrome P450, CYP1A1 genotypes, and their interaction. ( 9077484 )	Lear J.T....Fryer A.A.	1997
12	Three cases of multiple basal cell carcinoma arising in port-wine stains previously treated with thorium X. ( 8977700 )	Shah M...Palmer IR	1996
13	Multiple basal cell carcinoma associated with keratoacanthoma. ( 1292252 )		1992
14	Multiple basal cell carcinoma in tropical Australia. ( 1459761 )	Czarnecki D...Tait B	1992
15	Benzo(a)pyrene metabolism, DNA-binding and UV-induced repair of DNA damage in cultured skin fibroblasts from a patient with unilateral multiple basal cell carcinoma. ( 2923792 )	Don PS...Bickers DR	1989
16	Multiple basal-cell carcinoma of the vulva. ( 6747076 )	Goldberg DJ	1984
17	Decreased lymphocyte blastogenic responses in patients with multiple basal cell carcinoma. ( 7240477 )	Myskowski PL...Good RA	1981
18	Multiple basal cell carcinoma 58 years after X-ray therapy. ( 507882 )	van Dijk TJ...Mali WJ	1979
19	Multiple basal cell carcinoma and internal malignant tumors. ( 1130803 )	M?ller R...Reymann F	1975
20	Multiple basal cell carcinoma in a 24-year-old man. ( 5641342 )	Burgoon CF...Tuckman DJ	1968
21	Unusual case of multiple basal cell carcinoma with metastasis to the parotid lymph gland. ( 5673242 )	Hirshowitz B...Mahler D	1968

Sources

Genes for Basal Cell Carcinoma, Multiple

Genes related to Basal Cell Carcinoma, Multiple (4 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	PTCH1	Patched 1	Protein Coding	121.35	Genetic Tests ²⁹ Novoseek inferred ⁵⁵	8001963 7829076 12175781 (more) 15690381 16280022 17492539 15545745 8352281 11896785 15712338 11277394 11744885 12604725
2	RASA1	RAS P21 Protein Activator 1	Protein Coding	100	Genetic Tests ²⁹
3	PTCH2	Patched 2	Protein Coding	100	Genetic Tests ²⁹
4	SMO	Smoothened, Frizzled Class Receptor	Protein Coding	100	Genetic Tests ²⁹
5	SLC45A2	Solute Carrier Family 45 Member 2	Protein Coding	16.75	GeneCards inferred via : Publications (show sections)
6	CYP1A1	Cytochrome P450 Family 1 Subfamily A Member 1	Protein Coding	14.6	Novoseek inferred ⁵⁵	9077484

Sources

Variations for Basal Cell Carcinoma, Multiple

Sources

Expression for Basal Cell Carcinoma, Multiple

Search GEO for disease gene expression data for Basal Cell Carcinoma, Multiple.

Sources

Pathways for Basal Cell Carcinoma, Multiple

Pathways related to Basal Cell Carcinoma, Multiple according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	G-Beta Gamma Signaling ⁶⁴ Show member pathways CRHR Pathway ⁶⁴ GHRH Signaling ⁶⁴ Hedgehog Signaling in Mammals ⁶⁴ Relaxin Pathway ⁶⁴ Signaling in Gap Junctions ⁶⁴	12.48	PTCH1 PTCH2 SMO
2	Pathways in cancer ³⁷	12.3	PTCH1 PTCH2 SMO
3	Presynaptic function of Kainate receptors ⁶⁶ Show member pathways Activation of Ca-permeable Kainate Receptor ⁶⁶ Activation of Kainate Receptors upon glutamate binding ⁶⁶ Activation of Na-permeable Kainate Receptors ⁶⁶ Calcitonin-like ligand receptors ⁶⁶ Class B/2 (Secretin family receptors) ⁶⁶ G beta-gamma signalling through PLC beta ⁶⁶ Glucagon-type ligand receptors ⁶⁶ G-Protein Signaling through Tubby Protein ⁶⁴ Ionotropic activity of Kainate Receptors ⁶⁶	11.9	PTCH1 PTCH2 SMO
4	Axon guidance ³⁷	11.68	PTCH1 RASA1 SMO
5	Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling ⁶⁵ Show member pathways Basal cell carcinoma ³⁷	11.51	PTCH1 PTCH2 SMO
6	Hedgehog Pathway ⁷² Show member pathways GLI proteins bind promoters of Hh responsive genes to promote transcription ⁶⁶ Hedgehog signaling events mediated by Gli proteins ¹ Hedgehog signaling pathway ³⁷ Hedgehog Signaling Pathway ¹	11.24	PTCH1 PTCH2 SMO
7	Development_Hedgehog and PTH signaling pathways in bone and cartilage development ²²	10.96	PTCH1 SMO
8	Signaling events mediated by the Hedgehog family ¹ Show member pathways Ligand-receptor interactions ⁶⁶	10.28	PTCH1 PTCH2 SMO

Sources

GO Terms for Basal Cell Carcinoma, Multiple

Cellular components related to Basal Cell Carcinoma, Multiple according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	caveola	GO:0005901	9.16	PTCH1 SMO
2	endocytic vesicle membrane	GO:0030666	8.96	PTCH1 SMO
3	ciliary membrane	GO:0060170	8.62	PTCH1 SMO

Biological processes related to Basal Cell Carcinoma, Multiple according to GeneCards Suite gene sharing:

(show all 19)

#	Name	GO ID	Score	Top Affiliating Genes
1	response to organic cyclic compound	GO:0014070	9.58	CYP1A1 PTCH1
2	epidermis development	GO:0008544	9.58	PTCH1 PTCH2
3	pattern specification process	GO:0007389	9.57	PTCH1 SMO
4	vasculogenesis	GO:0001570	9.56	RASA1 SMO
5	heart morphogenesis	GO:0003007	9.55	PTCH1 SMO
6	dorsal/ventral pattern formation	GO:0009953	9.54	PTCH1 SMO
7	digestive tract development	GO:0048565	9.52	CYP1A1 SMO
8	embryonic organ development	GO:0048568	9.51	PTCH1 SMO
9	negative regulation of smoothened signaling pathway	GO:0045879	9.49	PTCH1 PTCH2
10	renal system development	GO:0072001	9.48	PTCH1 SMO
11	cell fate determination	GO:0001709	9.46	PTCH1 PTCH2
12	cellular response to cholesterol	GO:0071397	9.43	PTCH1 SMO
13	somite development	GO:0061053	9.4	PTCH1 SMO
14	dorsal/ventral neural tube patterning	GO:0021904	9.37	PTCH1 SMO
15	mammary gland epithelial cell differentiation	GO:0060644	9.32	PTCH1 SMO
16	commissural neuron axon guidance	GO:0071679	9.26	PTCH1 SMO
17	positive regulation of epidermal cell differentiation	GO:0045606	9.16	PTCH1 PTCH2
18	smoothened signaling pathway	GO:0007224	9.13	PTCH1 PTCH2 SMO
19	epidermal cell fate specification	GO:0009957	8.62	PTCH1 PTCH2

Molecular functions related to Basal Cell Carcinoma, Multiple according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	patched binding	GO:0005113	9.26	PTCH1 SMO
2	hedgehog family protein binding	GO:0097108	9.16	PTCH1 PTCH2
3	hedgehog receptor activity	GO:0008158	8.96	PTCH1 PTCH2
4	smoothened binding	GO:0005119	8.62	PTCH1 PTCH2

Sources

Sources for Basal Cell Carcinoma, Multiple

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia