MCID: BSL011
MIFTS: 40

Basal Cell Carcinoma, Multiple

Categories: Cancer diseases, Genetic diseases, Rare diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Basal Cell Carcinoma, Multiple

MalaCards integrated aliases for Basal Cell Carcinoma, Multiple:

Name: Basal Cell Carcinoma, Multiple 53 29 55 6 72
Multiple Basal Cell Carcinoma 53

Classifications:



External Ids:

UMLS 72 C1854245

Summaries for Basal Cell Carcinoma, Multiple

MalaCards based summary : Basal Cell Carcinoma, Multiple, also known as multiple basal cell carcinoma, is related to basal cell carcinoma and basal cell nevus syndrome. An important gene associated with Basal Cell Carcinoma, Multiple is RASA1 (RAS P21 Protein Activator 1), and among its related pathways/superpathways are Pathways in cancer and Presynaptic function of Kainate receptors. The drugs Verteporfin and Dermatologic Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and lung, and related phenotypes are cardiovascular system and digestive/alimentary

Related Diseases for Basal Cell Carcinoma, Multiple

Diseases in the Small Cell Carcinoma family:

Basal Cell Carcinoma 1 Basal Cell Carcinoma 2
Basal Cell Carcinoma 3 Basal Cell Carcinoma 4
Basal Cell Carcinoma 5 Basal Cell Carcinoma 6
Basal Cell Carcinoma 7 Cell Type Cancer
Basal Cell Carcinoma Large Cell Carcinoma
Basal Cell Carcinoma, Multiple

Diseases related to Basal Cell Carcinoma, Multiple via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 84, show less)
# Related Disease Score Top Affiliating Genes
1 basal cell carcinoma 29.0 SMO RASA1 PTCH2 PTCH1
2 basal cell nevus syndrome 28.8 SMO PTCH2 PTCH1
3 bazex syndrome 11.8
4 basal cell carcinoma 1 11.4
5 nevus, epidermal 10.1
6 skin atrophy 10.1
7 tinea capitis 10.1
8 dermatophytosis 10.1
9 spondyloarthropathy 1 10.1
10 inflammatory spondylopathy 10.1
11 skin carcinoma 10.1
12 hypotrichosis 10.1
13 spondylitis 10.1
14 myotonic dystrophy 10.1
15 myotonia atrophica 10.1
16 phacomatosis pigmentokeratotica 10.1
17 phakomatosis pigmentokeratotica 10.1
18 holoprosencephaly 7 10.1 PTCH1 LOC100507346
19 capillary malformations, congenital 10.0
20 xeroderma pigmentosum, variant type 10.0
21 anhidrosis 10.0
22 lentigines 9.8
23 pheochromocytoma 9.8
24 dowling-degos disease 1 9.8
25 triiodothyronine receptor auxiliary protein 9.8
26 congenital heart defects, hamartomas of tongue, and polysyndactyly 9.8
27 cartilage-hair hypoplasia 9.8
28 mycosis fungoides 9.8
29 focal dermal hypoplasia 9.8
30 ataxia and polyneuropathy, adult-onset 9.8
31 brooke-spiegler syndrome 9.8
32 nasopharyngeal carcinoma 9.8
33 basal cell carcinoma 2 9.8
34 nevus comedonicus 9.8
35 oculocutaneous albinism 9.8
36 chronic venous insufficiency 9.8
37 adrenal gland pheochromocytoma 9.8
38 venous insufficiency 9.8
39 lymphocytic leukemia 9.8
40 rickets 9.8
41 erysipelas 9.8
42 allergic hypersensitivity disease 9.8
43 entropion 9.8
44 leukemia 9.8
45 squamous cell papilloma 9.8
46 amenorrhea 9.8
47 rheumatic disease 9.8
48 lymphadenitis 9.8
49 keratosis 9.8
50 melanoma 9.8
51 enthesopathy 9.8
52 papilloma 9.8
53 kidney cancer 9.8
54 benign mesothelioma 9.8
55 dermatitis 9.8
56 pulmonary tuberculosis 9.8
57 keratoacanthoma 9.8
58 merkel cell carcinoma 9.8
59 spindle cell carcinoma 9.8
60 pigmented basal cell carcinoma 9.8
61 adenoid basal cell carcinoma 9.8
62 superficial basal cell carcinoma 9.8
63 pustulosis of palm and sole 9.8
64 eccrine acrospiroma 9.8
65 syringocystadenoma papilliferum 9.8
66 follicular infundibulum tumor 9.8
67 in situ carcinoma 9.8
68 actinic keratosis 9.8
69 psoriasis 9.8
70 learning disability 9.8
71 alopecia 9.8
72 albinism 9.8
73 bap1 tumor predisposition syndrome 9.8
74 cerebellar degeneration 9.8
75 erythrokeratoderma ''en cocardes'' 9.8
76 pili torti 9.8
77 9q22.3 microdeletion 9.8
78 spinocerebellar degeneration 9.8
79 lymphedema 9.8
80 parkes weber syndrome 9.8 RASA1 CCNH
81 weber syndrome 9.8 RASA1 CCNH
82 keratocystic odontogenic tumor 9.6 SMO PTCH1
83 ameloblastoma 9.5 SMO PTCH1
84 medulloblastoma 8.9 SMO PTCH2 PTCH1

Graphical network of the top 20 diseases related to Basal Cell Carcinoma, Multiple:



Diseases related to Basal Cell Carcinoma, Multiple

Symptoms & Phenotypes for Basal Cell Carcinoma, Multiple

MGI Mouse Phenotypes related to Basal Cell Carcinoma, Multiple:

46 (showing 3, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.55 CYP1A1 PTCH1 PTCH2 RASA1 SMO
2 digestive/alimentary MP:0005381 9.26 PTCH1 PTCH2 RASA1 SMO
3 muscle MP:0005369 8.92 PTCH1 PTCH2 RASA1 SMO

Drugs & Therapeutics for Basal Cell Carcinoma, Multiple

Drugs for Basal Cell Carcinoma, Multiple (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 18, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Verteporfin Approved, Investigational Phase 3 129497-78-5
2 Dermatologic Agents Phase 3
3 Photosensitizing Agents Phase 3
4
Aminolevulinic acid Approved Phase 1 106-60-5 137
5
Vitamin D3 Approved, Nutraceutical Phase 1 67-97-0 6221 5280795
6
Ergocalciferol Approved, Nutraceutical Phase 1 50-14-6 5280793
7
Vitamin D Approved, Nutraceutical, Vet_approved Phase 1 1406-16-2
8
Calcium Approved, Nutraceutical Phase 1 7440-70-2 271
9 Micronutrients Phase 1
10 Hormones Phase 1
11 Vitamins Phase 1
12 Ergocalciferols Phase 1
13 Nutrients Phase 1
14 Vitamin D2 Phase 1
15 Trace Elements Phase 1
16 Calciferol Phase 1
17 Calcium, Dietary Phase 1
18 Bone Density Conservation Agents Phase 1

Interventional clinical trials:

(showing 5, show less)
# Name Status NCT ID Phase Drugs
1 A Randomized, Placebo-Controlled, Masked, Multicenter Phase III Study Of Photodynamic Therapy With Verteporfin For Injection (VFI) For The Treatment Of Multiple Basal Cell Carcinoma Terminated NCT00049959 Phase 3 verteporfin PDT
2 A Randomized, Double-blinded, Regimen-controlled, Phase II, Multicenter Study to Assess the Efficacy and Safety of Two Different Vismodegib Regimens in Patients With Multiple Basal Cell Carcinomas Completed NCT01815840 Phase 2 Vismodegib;Placebo
3 Photodynamic Therapy and Vismodegib for Multiple Basal Cell Carcinomas Completed NCT02639117 Phase 1 Vismodegib
4 Vitamin D as a Nutritional Neoadjuvant During Photodynamic Therapy of Basal Cell Carcinoma in Basal Cell Nevus Syndrome Recruiting NCT03483441 Phase 1 PDT
5 Vitamin D as a Nutritional Neoadjuvant During Photodynamic Therapy of Basal Cell Carcinoma in Basal Cell Nevus Syndrome Recruiting NCT03467789

Search NIH Clinical Center for Basal Cell Carcinoma, Multiple

Genetic Tests for Basal Cell Carcinoma, Multiple

Genetic tests related to Basal Cell Carcinoma, Multiple:

# Genetic test Affiliating Genes
1 Basal Cell Carcinoma, Multiple 29 PTCH1 PTCH2 RASA1 SMO

Anatomical Context for Basal Cell Carcinoma, Multiple

MalaCards organs/tissues related to Basal Cell Carcinoma, Multiple:

41
Skin, Bone, Lung, B Cells

Publications for Basal Cell Carcinoma, Multiple

Articles related to Basal Cell Carcinoma, Multiple:

(showing 66, show less)
# Title Authors PMID Year
1
[Skeletal and dermatological manifestations of the nevoid Basal cell carcinoma syndrome (Gorlin-Goltz syndrome). Results of 8 patients in 12 years]. 9 38
17492539 2007
2
Molecular characterization of Italian nevoid basal cell carcinoma syndrome patients. 9 38
15712338 2005
3
A new germline mutation of the PTCH gene in a Japanese patient with nevoid basal cell carcinoma syndrome associated with meningioma. 9 38
12604725 2003
4
Truncal tumor site is associated with high risk of multiple basal cell carcinoma and is influenced by glutathione S-transferase, GSTT1, and cytochrome P450, CYP1A1 genotypes, and their interaction. 9 38
9077484 1997
5
A clinical review of reconstructive techniques for patients with multiple skin cancers on the face. 38
30282429 2018
6
Multiple Basal Cell Carcinoma Arising in a Verrucous Epidermal Naevus: Clinical, Histological and Therapeutic Observations. 38
28759100 2018
7
Correlates of multiple basal cell carcinoma in a retrospective cohort study: Sex, histologic subtypes, and anatomic distribution. 38
28392289 2017
8
Confocal and dermoscopic features of basal cell carcinoma in Gorlin-Goltz syndrome: A case report. 38
26768321 2017
9
The clinicopathological spectrum of trichoepitheliomas: a retrospective descriptive study. 38
26220252 2016
10
Treatment of multiple unresectable basal cell carcinomas from Gorlin-Goltz syndrome: a case report. 38
25750342 2015
11
Multiple nevoid basal cell carcinoma syndrome associated with congenital orbital teratoma, caused by a PTCH1 frameshift mutation. 38
25117323 2014
12
Metastatic Basal cell carcinoma accompanying gorlin syndrome. 38
25506011 2014
13
Multiple tumor types including leiomyoma and Wilms tumor in a patient with Gorlin syndrome due to 9q22.3 microdeletion encompassing the PTCH1 and FANC-C loci. 38
24124115 2013
14
Familial Multiple Basal Cell Carcinoma (Gorlin's Syndrome): A Case Report of a Father and Son. 38
24249904 2013
15
Treatment of Gorlin syndrome (nevoid basal cell carcinoma syndrome) with methylaminolevulinate photodynamic therapy in seven patients, including two children: interest of tumescent anesthesia for pain control in children. 38
22500823 2013
16
Multiple metastatic basal cell carcinoma with concurrent metastatic pleomorphic sarcoma in chronic lymphedema area--case report. 38
23197211 2012
17
Oral diffuse B-cell non-Hodgkin's lymphoma associated to Gorlin-Goltz syndrome: a case report with one year follow-up. 38
21623100 2011
18
Cutaneous cancers in an interventional cardiologist: a cautionary tale. 38
21114530 2011
19
Porokeratosis of Mibelli: Successful treatment with 5 percent topical imiquimod and topical 5 percent 5-fluorouracil. 38
21199636 2010
20
Risk factors for single and multiple basal cell carcinomas. 38
20713815 2010
21
Simultaneous treatment of multiple basal cell carcinoma lesions. 38
19029050 2008
22
Multiple hypersonographic spots in basal cell carcinoma. 38
17903154 2007
23
Optimizing meso-tetra-hydroxyphenyl-chlorin-mediated photodynamic therapy for basal cell carcinoma. 38
16984216 2006
24
Impaired removal of 8-hydroxydeoxyguanosine induced by UVB radiation in naevoid basal cell carcinoma syndrome cells. 9
16280022 2005
25
Long-term toxic effects of radiations: sarcomatoid carcinoma and multiple basal cell carcinoma of the limbs in chronic radiodermatitis. 38
15803869 2005
26
Delineation of an interstitial 9q22 deletion in basal cell nevus syndrome. 9
15690381 2005
27
Radiological features in 82 patients with nevoid basal cell carcinoma (NBCC or Gorlin) syndrome. 9
15545745 2004
28
Merkel cell carcinoma and multiple basal cell carcinoma in an African albino woman with HIV infection. 38
15544700 2004
29
Onset of multiple basal cell carcinoma 60 years after X-ray treatment for tinea capitis. 38
15096161 2004
30
Tissue and tumor mosaicism of the myotonin protein kinase gene trinucleotide repeat in a patient with multiple basal cell carcinomas associated with myotonic dystrophy. 38
14726854 2004
31
Effects of chlorin-mediated photodynamic therapy combined with fluoropyrimidines in vitro and in a patient. 38
12647016 2003
32
Novel mutations in the PATCHED gene in basal cell nevus syndrome. 9
12175781 2002
33
Ultrapulse CO2 used for the successful treatment of basal cell carcinomas found in patients with basal cell nevus syndrome. 9
11896785 2002
34
[Experience with glyciphonic ointment therapy for primary multiple basal cell carcinoma of the skin]. 38
12530271 2002
35
[Gorlin-Goltz syndrome]. 9
11744885 2001
36
Two male patients with nevoid basal cell carcinoma syndrome from Turkey. 38
11765170 2001
37
PTCH mutations in squamous cell carcinoma of the skin. 38
11286632 2001
38
A novel polymorphism in the PTC gene allows easy identification of allelic loss in basal cell nevus syndrome lesions. 9
11277394 2001
39
Nonsyndromic type of hereditary multiple basal cell carcinoma. 38
11078568 2000
40
Multiple basal cell carcinomas and malignant melanoma following radiotherapy for ankylosing spondylitis. 38
11012589 2000
41
[Clinico-epidemiologic characteristics of superficial multiple basal cell carcinoma at the Dermatovenereology Clinic in Novi Sad 1986-1996]. 38
10352507 1999
42
Multiple basal cell carcinoma developing two years after 60Co irradiation. 38
9649688 1998
43
Multiple basal cell carcinoma. A clinical evaluation of risk factors. 38
9534891 1998
44
Three cases of multiple basal cell carcinoma arising in port-wine stains previously treated with thorium X. 38
8977700 1996
45
[Retinoids in chemoprevention of tumors of the skin and mucous membranes. Theoretical principles and practical applications]. 38
8002334 1994
46
A YAC contig spanning the nevoid basal cell carcinoma syndrome, Fanconi anaemia group C, and xeroderma pigmentosum group A loci on chromosome 9q. 9
7829076 1994
47
Malignant meningioma in Gorlin's syndrome: cytogenetic and p53 gene analysis. Case report. 38
8057157 1994
48
Fine genetic mapping of the gene for nevoid basal cell carcinoma syndrome. 9
8001963 1994
49
Further localization of the gene for nevoid basal cell carcinoma syndrome (NBCCS) in 15 Australasian families: linkage and loss of heterozygosity. 9
8352281 1993
50
Multiple basal cell carcinoma in tropical Australia. 38
1459761 1992
51
Multiple basal cell carcinoma associated with keratoacanthoma. 38
1292252 1992
52
Benzo(a)pyrene metabolism, DNA-binding and UV-induced repair of DNA damage in cultured skin fibroblasts from a patient with unilateral multiple basal cell carcinoma. 38
2923792 1989
53
Basal cell carcinomas and lymphoma: biologic behavior and associated factors in sixty-three patients. 38
3204176 1988
54
[Basal-cell nevomatosis associated with multifocal fetal rhabdomyoma. A case]. 38
2974590 1988
55
Basal cell carcinoma with lung metastasis. 38
4032866 1985
56
Multiple basal-cell carcinoma of the vulva. 38
6747076 1984
57
Laser phototherapy following HpD administration in superficial neoplastic lesions. 38
6474583 1984
58
Decreased lymphocyte blastogenic responses in patients with multiple basal cell carcinoma. 38
7240477 1981
59
Multiple basal cell carcinoma 58 years after X-ray therapy. 38
507882 1979
60
Neurocutaneous syndromes and retroperitoneal tumors. 38
442351 1979
61
Two cases of nevoid basal cell carcinoma syndrome. 38
930589 1977
62
Multiple basal cell carcinoma and internal malignant tumors. 38
1130803 1975
63
Unusual case of multiple basal cell carcinoma with metastasis to the parotid lymph gland. 38
5673242 1968
64
Multiple basal cell carcinoma in a 24-year-old man. 38
5641342 1968
65
Basal cell carcinoma: multiple lesions. 38
5923808 1966
66
[Experimental production of cutaneous neoplastic proliferation by scarification and estrogen application in a case of multiple basal cell carcinoma of the trunk]. 38
13343909 1956

Variations for Basal Cell Carcinoma, Multiple

ClinVar genetic disease variations for Basal Cell Carcinoma, Multiple:

6 (showing 27, show less)
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 RASA1 NM_002890.3(RASA1): c.656C> G (p.Ser219Ter) single nucleotide variant Pathogenic rs1554044823 5:86627281-86627281 5:87331464-87331464
2 RASA1 NM_002890.3(RASA1): c.2131C> T (p.Arg711Ter) single nucleotide variant Pathogenic rs863223718 5:86672329-86672329 5:87376512-87376512
3 PTCH1 NM_001083602.2(PTCH1): c.2437G> A (p.Asp813Asn) single nucleotide variant Uncertain significance rs750373573 9:98224206-98224206 9:95461924-95461924
4 PTCH1 NM_001083602.2(PTCH1): c.3845A> G (p.Asn1282Ser) single nucleotide variant Uncertain significance rs371943557 9:98209495-98209495 9:95447213-95447213
5 PTCH1 NM_001083602.2(PTCH1): c.2473G> A (p.Gly825Ser) single nucleotide variant Uncertain significance rs570091335 9:98224170-98224170 9:95461888-95461888
6 PTCH1 NM_001083602.2(PTCH1): c.1791G> C (p.Gln597His) single nucleotide variant Uncertain significance rs753002023 9:98231294-98231294 9:95469012-95469012
7 PTCH2 NM_001166292.1(PTCH2): c.109C> T (p.Arg37Cys) single nucleotide variant Uncertain significance 1:45307675-45307675 1:44842003-44842003
8 PTCH1 NM_001083602.2(PTCH1): c.3940G> A (p.Ala1314Thr) single nucleotide variant Uncertain significance 9:98209400-98209400 9:95447118-95447118
9 PTCH1 NM_001083602.2(PTCH1): c.3851G> A (p.Arg1284Gln) single nucleotide variant Uncertain significance 9:98209489-98209489 9:95447207-95447207
10 PTCH1 NM_001083602.2(PTCH1): c.751C> T (p.Leu251Phe) single nucleotide variant Uncertain significance 9:98242369-98242369 9:95480087-95480087
11 PTCH1 NM_001083602.2(PTCH1): c.3377G> A (p.Arg1126His) single nucleotide variant Uncertain significance rs762040036 9:98211580-98211580 9:95449298-95449298
12 PTCH1 NM_001083602.2(PTCH1): c.214C> T (p.Arg72Cys) single nucleotide variant Uncertain significance rs139535966 9:98248139-98248139 9:95485857-95485857
13 PTCH2 NM_001166292.1(PTCH2): c.565C> G (p.Leu189Val) single nucleotide variant Uncertain significance rs747885797 1:45297430-45297430 1:44831758-44831758
14 PTCH1 NM_001083602.2(PTCH1): c.3710G> T (p.Arg1237Leu) single nucleotide variant Uncertain significance rs779365332 9:98209630-98209630 9:95447348-95447348
15 PTCH1 NM_001083602.2(PTCH1): c.703G> A (p.Asp235Asn) single nucleotide variant Uncertain significance rs767601899 9:98242716-98242716 9:95480434-95480434
16 PTCH1 NM_001083602.2(PTCH1): c.2089G> T (p.Val697Phe) single nucleotide variant Uncertain significance rs544963328 9:98229671-98229671 9:95467389-95467389
17 PTCH1 NM_001083602.2(PTCH1): c.3721C> T (p.Pro1241Ser) single nucleotide variant Uncertain significance rs574880967 9:98209619-98209619 9:95447337-95447337
18 PTCH1 NM_001083602.2(PTCH1): c.3964G> A (p.Gly1322Arg) single nucleotide variant Uncertain significance rs587778631 9:98209376-98209376 9:95447094-95447094
19 PTCH1 NM_001083602.2(PTCH1): c.3853A> G (p.Asn1285Asp) single nucleotide variant Uncertain significance rs786204103 9:98209487-98209487 9:95447205-95447205
20 PTCH1 NM_001083602.2(PTCH1): c.2242A> C (p.Asn748His) single nucleotide variant Uncertain significance rs754623561 9:98229518-98229518 9:95467236-95467236
21 PTCH1 NM_001083602.2(PTCH1): c.4-1726C> G single nucleotide variant Uncertain significance rs779791579 9:98270607-98270607 9:95508325-95508325
22 PTCH1 NM_001083602.2(PTCH1): c.4-1582G> A single nucleotide variant Uncertain significance rs150069331 9:98270463-98270463 9:95508181-95508181
23 PTCH1 NM_001083602.2(PTCH1): c.940G> A (p.Glu314Lys) single nucleotide variant Uncertain significance rs772903899 9:98241359-98241359 9:95479077-95479077
24 PTCH1 NM_001083602.2(PTCH1): c.3826C> T (p.Arg1276Cys) single nucleotide variant Uncertain significance rs781539921 9:98209514-98209514 9:95447232-95447232
25 PTCH1 NM_001083602.2(PTCH1): c.3536A> G (p.Gln1179Arg) single nucleotide variant Uncertain significance rs767792734 9:98211421-98211421 9:95449139-95449139
26 PTCH2 NM_001166292.1(PTCH2): c.3347C> T (p.Pro1116Leu) single nucleotide variant Uncertain significance rs539161089 1:45288751-45288751 1:44823079-44823079
27 PTCH2 NM_001166292.1(PTCH2): c.19C> G (p.Leu7Val) single nucleotide variant Uncertain significance rs1030456781 1:45308586-45308586 1:44842914-44842914

Expression for Basal Cell Carcinoma, Multiple

Search GEO for disease gene expression data for Basal Cell Carcinoma, Multiple.

Pathways for Basal Cell Carcinoma, Multiple

GO Terms for Basal Cell Carcinoma, Multiple

Cellular components related to Basal Cell Carcinoma, Multiple according to GeneCards Suite gene sharing:

(showing 3, show less)
# Name GO ID Score Top Affiliating Genes
1 caveola GO:0005901 9.16 SMO PTCH1
2 endocytic vesicle membrane GO:0030666 8.96 SMO PTCH1
3 ciliary membrane GO:0060170 8.62 SMO PTCH1

Biological processes related to Basal Cell Carcinoma, Multiple according to GeneCards Suite gene sharing:

(showing 18, show less)
# Name GO ID Score Top Affiliating Genes
1 epidermis development GO:0008544 9.58 PTCH2 PTCH1
2 pattern specification process GO:0007389 9.57 SMO PTCH1
3 vasculogenesis GO:0001570 9.56 SMO RASA1
4 heart morphogenesis GO:0003007 9.55 SMO PTCH1
5 dorsal/ventral pattern formation GO:0009953 9.54 SMO PTCH1
6 digestive tract development GO:0048565 9.52 SMO CYP1A1
7 embryonic organ development GO:0048568 9.51 SMO PTCH1
8 negative regulation of smoothened signaling pathway GO:0045879 9.49 PTCH2 PTCH1
9 renal system development GO:0072001 9.48 SMO PTCH1
10 cell fate determination GO:0001709 9.46 PTCH2 PTCH1
11 somite development GO:0061053 9.43 SMO PTCH1
12 cellular response to cholesterol GO:0071397 9.4 SMO PTCH1
13 dorsal/ventral neural tube patterning GO:0021904 9.37 SMO PTCH1
14 mammary gland epithelial cell differentiation GO:0060644 9.32 SMO PTCH1
15 commissural neuron axon guidance GO:0071679 9.26 SMO PTCH1
16 positive regulation of epidermal cell differentiation GO:0045606 9.16 PTCH2 PTCH1
17 smoothened signaling pathway GO:0007224 9.13 SMO PTCH2 PTCH1
18 epidermal cell fate specification GO:0009957 8.62 PTCH2 PTCH1

Molecular functions related to Basal Cell Carcinoma, Multiple according to GeneCards Suite gene sharing:

(showing 4, show less)
# Name GO ID Score Top Affiliating Genes
1 patched binding GO:0005113 9.26 SMO PTCH1
2 smoothened binding GO:0005119 9.16 PTCH2 PTCH1
3 hedgehog receptor activity GO:0008158 8.96 PTCH2 PTCH1
4 hedgehog family protein binding GO:0097108 8.62 PTCH2 PTCH1

Sources for Basal Cell Carcinoma, Multiple

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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