MCID: BSL003
MIFTS: 34

Basaloid Lung Carcinoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Basaloid Lung Carcinoma

MalaCards integrated aliases for Basaloid Lung Carcinoma:

Name: Basaloid Lung Carcinoma 12 15
Basaloid Lung Cancer 71

Classifications:



External Ids:

Disease Ontology 12 DOID:7045
NCIt 49 C7266
UMLS 71 C1332463 C2205887

Summaries for Basaloid Lung Carcinoma

MalaCards based summary : Basaloid Lung Carcinoma, also known as basaloid lung cancer, is related to mulchandani-bhoj-conlin syndrome and ovarian serous adenofibroma. An important gene associated with Basaloid Lung Carcinoma is CXCL13 (C-X-C Motif Chemokine Ligand 13), and among its related pathways/superpathways are DNA Damage and Gastric cancer. Affiliated tissues include lung, and related phenotypes are Synthetic lethal with cisplatin and integument

Related Diseases for Basaloid Lung Carcinoma

Diseases related to Basaloid Lung Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 157)
# Related Disease Score Top Affiliating Genes
1 mulchandani-bhoj-conlin syndrome 10.1 PGR BRCA1
2 ovarian serous adenofibroma 10.1 TP53 BRCA1
3 ovarian serous cystadenofibroma 10.1 TP53 BRCA1
4 pregnancy adenoma 10.1 PGR KRT5
5 lipid-rich breast carcinoma 10.1 PGR KRT5
6 external ear carcinoma 10.1 PGR KRT5
7 breast papillary carcinoma 10.1 PGR KRT5
8 breast metaplastic carcinoma 10.1 PGR KRT5
9 breast mucinous carcinoma 10.1 PGR KRT5
10 breast myoepithelial carcinoma 10.1 PGR KRT5
11 ovarian benign neoplasm 10.1 TP53 BRCA1
12 lipid-rich carcinoma 10.1 PGR KRT5
13 eccrine papillary adenocarcinoma 10.1 PGR KRT5
14 cutaneous adenocystic carcinoma 10.1 PGR KRT5
15 endometritis 10.1 PGR CXCL13
16 apocrine sweat gland neoplasm 10.0 PGR KRT5
17 ovarian cystadenoma 10.0 TP53 BRCA1
18 breast osteosarcoma 10.0 PGR KRT5
19 uterus leiomyosarcoma 10.0 PGR KRT5
20 gastric lymphoma 10.0 TP53 CXCL13
21 intraductal breast benign neoplasm 10.0 PGR KRT5
22 cribriform carcinoma 10.0 PGR KRT5
23 intraductal papilloma 10.0 PGR KRT5
24 bartholin's gland adenoma 10.0 TP53 PGR
25 bartholin's gland benign neoplasm 10.0 TP53 PGR
26 vestibular gland benign neoplasm 10.0 TP53 PGR
27 mucoepidermoid esophageal carcinoma 10.0 TP53 KRT5
28 endometrial squamous cell carcinoma 10.0 TP53 PGR
29 ovarian seromucinous carcinoma 10.0 TP53 PGR
30 apocrine adenosis of breast 10.0 TP53 PGR
31 necrotizing sialometaplasia 10.0 TP53 KRT5
32 comedo carcinoma 10.0 TP53 PGR
33 bizarre leiomyoma 10.0 TP53 PGR
34 eccrine sweat gland cancer 10.0 TP53 KRT5
35 large cell acanthoma 10.0 TP53 KRT5
36 breast adenoid cystic carcinoma 10.0 TP53 PGR
37 fallopian tube clear cell adenocarcinoma 10.0 BRCA2 BRCA1
38 rare malignant breast tumor 10.0 BRCA2 BRCA1
39 keratinizing squamous cell carcinoma 10.0 TP53 KRT5
40 ovary transitional cell carcinoma 10.0 BRCA2 BRCA1
41 hereditary site-specific ovarian cancer syndrome 10.0 BRCA2 BRCA1
42 familial ovarian cancer 10.0 BRCA2 BRCA1
43 tetraploidy 10.0 BRCA2 BRCA1
44 cancerophobia 10.0 BRCA2 BRCA1
45 clear cell basal cell carcinoma 10.0 TP53 KRT5
46 papillary adenoma 10.0 TP53 KRT5
47 nosophobia 10.0 BRCA2 BRCA1
48 esophageal adenosquamous carcinoma 10.0 TP53 KRT5
49 peritoneal serous adenocarcinoma 10.0 TP53 PGR
50 chordoid glioma 10.0 TP53 PGR

Graphical network of the top 20 diseases related to Basaloid Lung Carcinoma:



Diseases related to Basaloid Lung Carcinoma

Symptoms & Phenotypes for Basaloid Lung Carcinoma

GenomeRNAi Phenotypes related to Basaloid Lung Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with cisplatin GR00101-A-1 8.62 BRCA1 BRCA2

MGI Mouse Phenotypes related to Basaloid Lung Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.43 BRCA1 BRCA2 KRT5 PGR PRNP TP53
2 limbs/digits/tail MP:0005371 9.1 BRCA1 BRCA2 KRT5 PGR PRNP TP53

Drugs & Therapeutics for Basaloid Lung Carcinoma

Search Clinical Trials , NIH Clinical Center for Basaloid Lung Carcinoma

Genetic Tests for Basaloid Lung Carcinoma

Anatomical Context for Basaloid Lung Carcinoma

MalaCards organs/tissues related to Basaloid Lung Carcinoma:

40
Lung

Publications for Basaloid Lung Carcinoma

Articles related to Basaloid Lung Carcinoma:

# Title Authors PMID Year
1
Stage-specific embryonic antigen-4 is expressed in basaloid lung cancer and associated with poor prognosis. 61
22743677 2013
2
Pulmonary oligometastases: histological features and difficulties in determining site of origin. 61
22674914 2012

Variations for Basaloid Lung Carcinoma

Cosmic variations for Basaloid Lung Carcinoma:

9 (show top 50) (show all 1540)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM149314749 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1144G>T p.G382C 16:72959002-72959002 9
2 COSM149318860 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1172A>G p.Q391R 16:72958974-72958974 9
3 COSM143041512 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1316C>T p.P439L 11:102229729-102229729 9
4 COSM97230831 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1159A>C p.I387L 22:41653558-41653558 9
5 COSM85312404 XRCC1 lung,NS,carcinoma,undifferentiated carcinoma c.1207A>G p.M403V 19:43546970-43546970 9
6 COSM91372655 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 9
7 COSM91383011 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1360A>T p.K454* 11:32392044-32392044 9
8 COSM124478343 WNT8A lung,NS,carcinoma,undifferentiated carcinoma c.422G>C p.G141A 5:138088927-138088927 9
9 COSM87652733 WNT10B lung,NS,carcinoma,undifferentiated carcinoma c.1006A>C p.K336Q 12:48966259-48966259 9
10 COSM84601598 USP5 lung,NS,carcinoma,undifferentiated carcinoma c.755C>T p.T252I 12:6856877-6856877 9
11 COSM88410243 USP38 lung,NS,carcinoma,undifferentiated carcinoma c.994G>C p.A332P 4:143197868-143197868 9
12 COSM87541563 USP32 lung,NS,carcinoma,undifferentiated carcinoma c.192T>A p.I64= 17:60301699-60301699 9
13 COSM145430147 UHRF1 lung,NS,carcinoma,undifferentiated carcinoma c.1467C>G p.F489L 19:4947122-4947122 9
14 COSM127070824 UBR5 lung,NS,carcinoma,undifferentiated carcinoma c.2691A>T p.Q897H 8:102305221-102305221 9
15 COSM127059821 UBR5 lung,NS,carcinoma,undifferentiated carcinoma c.1555A>G p.S519G 8:102326590-102326590 9
16 COSM85195038 U2AF1 lung,NS,carcinoma,undifferentiated carcinoma c.319G>C p.D107H 21:43095467-43095467 9
17 COSM130300868 TYK2 lung,NS,carcinoma,undifferentiated carcinoma c.3560G>T p.C1187F 19:10350838-10350838 9
18 COSM131090496 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.1922C>T p.S641L 14:81143980-81143980 9
19 COSM131094722 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.412C>T p.L138F 14:81091088-81091088 9
20 COSM131094002 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.937A>C p.K313Q 14:81142995-81142995 9
21 COSM87049256 TSC2 lung,NS,carcinoma,undifferentiated carcinoma c.1840G>T p.A614S 16:2071510-2071510 9
22 COSM85721789 TSC1 lung,NS,carcinoma,undifferentiated carcinoma c.694G>T p.E232* 9:132921406-132921406 9
23 COSM90140992 TRAF7 lung,NS,carcinoma,undifferentiated carcinoma c.1193C>T p.P398L 16:2173978-2173978 9
24 COSM90145840 TRAF7 lung,NS,carcinoma,undifferentiated carcinoma c.1287C>G p.Y429* 16:2174274-2174274 9
25 COSM87090089 TRAF5 lung,NS,carcinoma,undifferentiated carcinoma c.302G>C p.R101T 1:211356392-211356392 9
26 COSM87898991 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.535C>T p.H179Y 17:7675077-7675077 9
27 COSM87901497 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.461G>T p.G154V 17:7675151-7675151 9
28 COSM87935416 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.499C>T p.Q167* 17:7675113-7675113 9
29 COSM87904420 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.514G>T p.V172F 17:7675098-7675098 9
30 COSM87898444 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.536A>G p.H179R 17:7675076-7675076 9
31 COSM87906107 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.473G>T p.R158L 17:7675139-7675139 9
32 COSM87909792 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.919+1G>T p.? 17:7673700-7673700 9
33 COSM87940740 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.811G>T p.E271* 17:7673809-7673809 9
34 COSM87899785 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.991C>T p.Q331* 17:7673537-7673537 9
35 COSM87902162 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.783-1G>T p.? 17:7673838-7673838 9
36 COSM87915599 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.842A>G p.D281G 17:7673778-7673778 9
37 COSM87897914 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.527G>T p.C176F 17:7675085-7675085 9
38 COSM87899377 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.375+1G>A p.? 17:7675993-7675993 9
39 COSM87900565 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.1024C>T p.R342* 17:7670685-7670685 9
40 COSM87918616 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.993+1G>A p.? 17:7673534-7673534 9
41 COSM87897711 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.818G>A p.R273H 17:7673802-7673802 9
42 COSM87900157 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.818G>T p.R273L 17:7673802-7673802 9
43 COSM87942817 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.376-1G>T p.? 17:7675237-7675237 9
44 COSM87903076 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.796G>T p.G266* 17:7673824-7673824 9
45 COSM87898836 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.560-1G>A p.? 17:7674972-7674972 9
46 COSM87898881 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.578A>G p.H193R 17:7674953-7674953 9
47 COSM150205149 TLR4 lung,NS,carcinoma,undifferentiated carcinoma c.337C>A p.P113T 9:117712465-117712465 9
48 COSM85378871 TLR2 lung,NS,carcinoma,undifferentiated carcinoma c.1169A>G p.Q390R 4:153704076-153704076 9
49 COSM90180942 TLN1 lung,NS,carcinoma,undifferentiated carcinoma c.5624C>T p.S1875L 9:35705660-35705660 9
50 COSM90180404 TLN1 lung,NS,carcinoma,undifferentiated carcinoma c.1087C>T p.P363S 9:35721665-35721665 9

Expression for Basaloid Lung Carcinoma

Search GEO for disease gene expression data for Basaloid Lung Carcinoma.

Pathways for Basaloid Lung Carcinoma

Pathways related to Basaloid Lung Carcinoma according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1 12.1 TP53 BRCA2 BRCA1
2
Show member pathways
11.92 TP53 PGR BRCA2 BRCA1
3 11.52 TP53 BRCA2 BRCA1
4 11.26 TP53 PRNP
5 11.22 TP53 BRCA1
6 11.16 TP53 BRCA1
7 11.12 TP53 BRCA1
8 11.05 TP53 PRNP
9 10.91 TP53 BRCA1
10 10.86 TP53 BRCA1
11 10.78 TP53 BRCA1
12
Show member pathways
10.72 TP53 BRCA2 BRCA1
13 10.54 TP53 BRCA1

GO Terms for Basaloid Lung Carcinoma

Cellular components related to Basaloid Lung Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lateral element GO:0000800 8.62 BRCA2 BRCA1

Biological processes related to Basaloid Lung Carcinoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 cell cycle GO:0007049 9.67 TP53 PRNP BRCA2 BRCA1
2 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.52 BRCA2 BRCA1
3 nucleotide-excision repair GO:0006289 9.51 TP53 BRCA2
4 chromosome organization GO:0051276 9.49 TP53 BRCA2
5 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.48 TP53 BRCA2
6 cell aging GO:0007569 9.46 TP53 BRCA2
7 positive regulation of cell cycle arrest GO:0071158 9.43 TP53 BRCA1
8 response to gamma radiation GO:0010332 9.4 TP53 BRCA2
9 negative regulation of reactive oxygen species metabolic process GO:2000378 9.32 TP53 BRCA1
10 response to X-ray GO:0010165 9.26 TP53 BRCA2
11 chordate embryonic development GO:0043009 9.16 BRCA2 BRCA1
12 double-strand break repair GO:0006302 9.13 TP53 BRCA2 BRCA1
13 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 8.8 TP53 BRCA2 BRCA1

Molecular functions related to Basaloid Lung Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 9.46 ZNF185 TP53 PGR BRCA1
2 identical protein binding GO:0042802 9.35 TP53 PRNP PGR BRCA2 BRCA1
3 protease binding GO:0002020 8.8 TP53 PRNP BRCA2

Sources for Basaloid Lung Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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