MCID: BSL003
MIFTS: 35

Basaloid Lung Carcinoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Basaloid Lung Carcinoma

MalaCards integrated aliases for Basaloid Lung Carcinoma:

Name: Basaloid Lung Carcinoma 12 15
Basaloid Lung Cancer 70

Classifications:



External Ids:

Disease Ontology 12 DOID:7045
NCIt 50 C7266
UMLS 70 C1332463 C2205887

Summaries for Basaloid Lung Carcinoma

MalaCards based summary : Basaloid Lung Carcinoma, also known as basaloid lung cancer, is related to mulchandani-bhoj-conlin syndrome and lipid-rich breast carcinoma. An important gene associated with Basaloid Lung Carcinoma is BRCA1 (BRCA1 DNA Repair Associated), and among its related pathways/superpathways are Chks in Checkpoint Regulation and Glioma. Affiliated tissues include lung, and related phenotypes are Decreased viability with cisplatin and Synthetic lethal with cisplatin

Related Diseases for Basaloid Lung Carcinoma

Diseases related to Basaloid Lung Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 169)
# Related Disease Score Top Affiliating Genes
1 mulchandani-bhoj-conlin syndrome 10.1 PGR BRCA1
2 lipid-rich breast carcinoma 10.1 PGR KRT5
3 pregnancy adenoma 10.1 PGR KRT5
4 external ear carcinoma 10.1 PGR KRT5
5 breast papillary carcinoma 10.1 PGR KRT5
6 breast myoepithelial carcinoma 10.1 PGR KRT5
7 breast metaplastic carcinoma 10.1 PGR KRT5
8 ovarian serous adenofibroma 10.1 TP53 BRCA1
9 breast mucinous carcinoma 10.1 PGR KRT5
10 ovarian serous cystadenofibroma 10.1 TP53 BRCA1
11 ovarian carcinosarcoma 10.1 TP53 BRCA1
12 lipid-rich carcinoma 10.1 PGR KRT5
13 eccrine papillary adenocarcinoma 10.1 PGR KRT5
14 cutaneous adenocystic carcinoma 10.1 PGR KRT5
15 breast osteosarcoma 10.1 PGR KRT5
16 apocrine sweat gland neoplasm 10.1 PGR KRT5
17 uterus leiomyosarcoma 10.1 PGR KRT5
18 apocrine adenocarcinoma 10.1 PGR KRT5
19 ovarian benign neoplasm 10.1 TP53 BRCA1
20 uterine corpus sarcoma 10.1 PGR KRT5
21 papillary adenoma 10.0 TP53 KRT5
22 intraductal breast benign neoplasm 10.0 PGR KRT5
23 cribriform carcinoma 10.0 PGR KRT5
24 bartholin's gland adenocarcinoma 10.0 PGR KRT5
25 intraductal papilloma 10.0 PGR KRT5
26 mucoepidermoid esophageal carcinoma 10.0 TP53 KRT5
27 bartholin's gland adenoma 10.0 TP53 PGR
28 bartholin's gland benign neoplasm 10.0 TP53 PGR
29 vestibular gland benign neoplasm 10.0 TP53 PGR
30 carcinosarcoma 10.0 TP53 PGR
31 ovarian seromucinous carcinoma 10.0 TP53 PGR
32 apocrine adenosis of breast 10.0 TP53 PGR
33 necrotizing sialometaplasia 10.0 TP53 KRT5
34 comedo carcinoma 10.0 TP53 PGR
35 large cell acanthoma 10.0 TP53 KRT5
36 acanthoma 10.0 TP53 KRT5
37 eccrine sweat gland cancer 10.0 TP53 KRT5
38 bizarre leiomyoma 10.0 TP53 PGR
39 cystadenofibroma 10.0 TP53 KRT5
40 esophageal adenosquamous carcinoma 10.0 TP53 KRT5
41 adenosquamous carcinoma 10.0 TP53 KRT5
42 clear cell basal cell carcinoma 10.0 TP53 KRT5
43 peritoneal serous adenocarcinoma 10.0 TP53 PGR
44 cervical adenosarcoma 10.0 TP53 PGR
45 adenosarcoma 10.0 TP53 PGR
46 keratinizing squamous cell carcinoma 10.0 TP53 KRT5
47 chordoid glioma 10.0 TP53 PGR
48 vaginal cancer 10.0 TP53 PGR
49 fallopian tube clear cell adenocarcinoma 10.0 BRCA2 BRCA1
50 microglandular adenosis 10.0 TP53 PGR

Graphical network of the top 20 diseases related to Basaloid Lung Carcinoma:



Diseases related to Basaloid Lung Carcinoma

Symptoms & Phenotypes for Basaloid Lung Carcinoma

GenomeRNAi Phenotypes related to Basaloid Lung Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with cisplatin GR00101-A-4 8.96 BRCA1 BRCA2
2 Synthetic lethal with cisplatin GR00101-A-1 8.62 BRCA1 BRCA2

MGI Mouse Phenotypes related to Basaloid Lung Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.93 BRCA1 BRCA2 KRT5 PGR PRNP TP53
2 immune system MP:0005387 9.88 BRCA1 BRCA2 KRT5 PGR PRNP TP53
3 integument MP:0010771 9.85 BRCA1 BRCA2 KRT5 PGR PRNP TP53
4 endocrine/exocrine gland MP:0005379 9.83 BRCA1 BRCA2 PGR PRNP TP53
5 limbs/digits/tail MP:0005371 9.8 BRCA1 BRCA2 KRT5 PGR PRNP TP53
6 neoplasm MP:0002006 9.56 BRCA1 BRCA2 PGR TP53
7 normal MP:0002873 9.55 BRCA1 BRCA2 PGR PRNP TP53
8 reproductive system MP:0005389 9.35 BRCA1 BRCA2 PGR PRNP TP53
9 skeleton MP:0005390 9.02 BRCA1 BRCA2 PGR PRNP TP53

Drugs & Therapeutics for Basaloid Lung Carcinoma

Search Clinical Trials , NIH Clinical Center for Basaloid Lung Carcinoma

Genetic Tests for Basaloid Lung Carcinoma

Anatomical Context for Basaloid Lung Carcinoma

MalaCards organs/tissues related to Basaloid Lung Carcinoma:

40
Lung

Publications for Basaloid Lung Carcinoma

Articles related to Basaloid Lung Carcinoma:

# Title Authors PMID Year
1
Stage-specific embryonic antigen-4 is expressed in basaloid lung cancer and associated with poor prognosis. 61
22743677 2013
2
Pulmonary oligometastases: histological features and difficulties in determining site of origin. 61
22674914 2012

Variations for Basaloid Lung Carcinoma

Cosmic variations for Basaloid Lung Carcinoma:

9 (show top 50) (show all 1540)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM102042323 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.-23-8009A>G p.? 16:72958974-72958974 6
2 COSM87291734 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1172A>G p.Q391R 16:72958974-72958974 6
3 COSM102040476 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.-23-8037G>T p.? 16:72959002-72959002 6
4 COSM149314749 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1144G>T p.G382C 16:72959002-72959002 6
5 COSM87290218 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1144G>T p.G382C 16:72959002-72959002 6
6 COSM149318860 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1172A>G p.Q391R 16:72958974-72958974 6
7 COSM126973051 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.770C>T p.P257L 11:102229729-102229729 6
8 COSM145028029 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1154C>T p.P385L 11:102229729-102229729 6
9 COSM128452039 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1142C>T p.P381L 11:102229729-102229729 6
10 COSM85237448 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1304C>T p.P435L 11:102229729-102229729 6
11 COSM143041512 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1316C>T p.P439L 11:102229729-102229729 6
12 COSM127997731 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1256C>T p.P419L 11:102229729-102229729 6
13 COSM133274224 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1268C>T p.P423L 11:102229729-102229729 6
14 COSM90948266 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1202C>T p.P401L 11:102229729-102229729 6
15 COSM108017622 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1009A>C p.I337L 22:41653558-41653558 6
16 COSM95166535 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1159A>C p.I387L 22:41653558-41653558 6
17 COSM97230831 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1159A>C p.I387L 22:41653558-41653558 6
18 COSM105839764 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1009A>C p.I337L 22:41653558-41653558 6
19 COSM106337415 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1159A>C p.I387L 22:41653558-41653558 6
20 COSM103711109 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1036A>C p.I346L 22:41653558-41653558 6
21 COSM85312404 XRCC1 lung,NS,carcinoma,undifferentiated carcinoma c.1207A>G p.M403V 19:43546970-43546970 6
22 COSM134125623 XRCC1 lung,NS,carcinoma,undifferentiated carcinoma c.1114A>G p.M372V 19:43546970-43546970 6
23 COSM100781761 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.724A>T p.K242* 11:32392044-32392044 6
24 COSM111539040 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1309A>T p.K437* 11:32392044-32392044 6
25 COSM149728755 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 6
26 COSM130518653 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.673A>T p.K225* 11:32392044-32392044 6
27 COSM113475703 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 6
28 COSM111529696 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 6
29 COSM113484991 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1360A>T p.K454* 11:32392044-32392044 6
30 COSM147414475 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 6
31 COSM149739953 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1360A>T p.K454* 11:32392044-32392044 6
32 COSM148580942 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 6
33 COSM148593279 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1360A>T p.K454* 11:32392044-32392044 6
34 COSM91372655 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 6
35 COSM91383011 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1360A>T p.K454* 11:32392044-32392044 6
36 COSM147426277 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1309A>T p.K437* 11:32392044-32392044 6
37 COSM124478343 WNT8A lung,NS,carcinoma,undifferentiated carcinoma c.422G>C p.G141A 5:138088927-138088927 6
38 COSM104050903 WNT8A lung,NS,carcinoma,undifferentiated carcinoma c.368G>C p.G123A 5:138088927-138088927 6
39 COSM105123686 WNT10B lung,NS,carcinoma,undifferentiated carcinoma c.*288A>C p.? 12:48966259-48966259 6
40 COSM87652733 WNT10B lung,NS,carcinoma,undifferentiated carcinoma c.1006A>C p.K336Q 12:48966259-48966259 6
41 COSM102763785 WNT10B lung,NS,carcinoma,undifferentiated carcinoma c.*288A>C p.? 12:48966259-48966259 6
42 COSM99767946 USP5 lung,NS,carcinoma,undifferentiated carcinoma c.755C>T p.T252I 12:6856877-6856877 6
43 COSM84601598 USP5 lung,NS,carcinoma,undifferentiated carcinoma c.755C>T p.T252I 12:6856877-6856877 6
44 COSM121848752 USP38 lung,NS,carcinoma,undifferentiated carcinoma c.994G>C p.A332P 4:143197868-143197868 6
45 COSM88410243 USP38 lung,NS,carcinoma,undifferentiated carcinoma c.994G>C p.A332P 4:143197868-143197868 6
46 COSM87541563 USP32 lung,NS,carcinoma,undifferentiated carcinoma c.192T>A p.I64= 17:60301699-60301699 6
47 COSM99795256 USP32 lung,NS,carcinoma,undifferentiated carcinoma c.192T>A p.I64= 17:60301699-60301699 6
48 COSM143996084 UHRF1 lung,NS,carcinoma,undifferentiated carcinoma c.1620C>G p.F540L 19:4947122-4947122 6
49 COSM143964403 UHRF1 lung,NS,carcinoma,undifferentiated carcinoma c.1428C>G p.F476L 19:4947122-4947122 6
50 COSM145430147 UHRF1 lung,NS,carcinoma,undifferentiated carcinoma c.1467C>G p.F489L 19:4947122-4947122 6

Expression for Basaloid Lung Carcinoma

Search GEO for disease gene expression data for Basaloid Lung Carcinoma.

Pathways for Basaloid Lung Carcinoma

Pathways related to Basaloid Lung Carcinoma according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.34 TP53 BRCA2 BRCA1
2
Show member pathways
12.31 TP53 BRCA2 BRCA1
3 12.08 TP53 BRCA2 BRCA1
4
Show member pathways
11.92 TP53 PGR BRCA2 BRCA1
5 11.52 TP53 BRCA2 BRCA1
6 11.43 TP53 BRCA1
7 11.37 TP53 BRCA1
8 11.26 TP53 PRNP
9 11.22 TP53 BRCA1
10 11.16 TP53 BRCA1
11 11.12 TP53 BRCA1
12 11.07 TP53 PRNP
13 10.91 TP53 BRCA1
14 10.86 TP53 BRCA1
15 10.78 TP53 BRCA1
16
Show member pathways
10.72 TP53 BRCA2 BRCA1
17 10.54 TP53 BRCA1

GO Terms for Basaloid Lung Carcinoma

Cellular components related to Basaloid Lung Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lateral element GO:0000800 8.62 BRCA2 BRCA1

Biological processes related to Basaloid Lung Carcinoma according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 cell cycle GO:0007049 9.56 TP53 PRNP BRCA2 BRCA1
2 cellular response to drug GO:0035690 9.55 TP53 PRNP
3 positive regulation of neuron apoptotic process GO:0043525 9.54 TP53 PRNP
4 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.52 BRCA2 BRCA1
5 nucleotide-excision repair GO:0006289 9.51 TP53 BRCA2
6 positive regulation of cell cycle arrest GO:0071158 9.49 TP53 BRCA1
7 chromosome organization GO:0051276 9.48 TP53 BRCA2
8 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.46 TP53 BRCA2
9 response to gamma radiation GO:0010332 9.43 TP53 BRCA2
10 cell aging GO:0007569 9.4 TP53 BRCA2
11 negative regulation of reactive oxygen species metabolic process GO:2000378 9.37 TP53 BRCA1
12 response to X-ray GO:0010165 9.32 TP53 BRCA2
13 chordate embryonic development GO:0043009 9.16 BRCA2 BRCA1
14 double-strand break repair GO:0006302 9.13 TP53 BRCA2 BRCA1
15 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 8.8 TP53 BRCA2 BRCA1

Molecular functions related to Basaloid Lung Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.35 TP53 PRNP PGR BRCA2 BRCA1
2 enzyme binding GO:0019899 9.33 TP53 PGR BRCA1
3 tubulin binding GO:0015631 9.32 PRNP BRCA1
4 copper ion binding GO:0005507 9.26 TP53 PRNP
5 protease binding GO:0002020 8.8 TP53 PRNP BRCA2

Sources for Basaloid Lung Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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