MCID: BSL006
MIFTS: 43

Basaloid Squamous Cell Carcinoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Basaloid Squamous Cell Carcinoma

MalaCards integrated aliases for Basaloid Squamous Cell Carcinoma:

Name: Basaloid Squamous Cell Carcinoma 12 15 17 70
Basaloid Carcinoma 12 17 70

Classifications:



External Ids:

Disease Ontology 12 DOID:5522
NCIt 50 C54244
SNOMED-CT 67 128634009
UMLS 70 C1266005 C1704216

Summaries for Basaloid Squamous Cell Carcinoma

Disease Ontology : 12 A squamous cell carcinoma that has a solid, closely packed growth of cells with hyperchromatic nuclei, scant cytoplasm, small cystic spaces, and foci of necrosis. It has overlying squamous dysplasia, rare foci of overt keratinization, and/or coexistent keratinizing squamous cell carcinoma.

MalaCards based summary : Basaloid Squamous Cell Carcinoma, also known as basaloid carcinoma, is related to cervical basaloid squamous cell carcinoma and esophageal basaloid squamous cell carcinoma. An important gene associated with Basaloid Squamous Cell Carcinoma is SYP (Synaptophysin), and among its related pathways/superpathways are Developmental Biology and MicroRNAs in cancer. The drugs nivolumab and Antineoplastic Agents, Immunological have been mentioned in the context of this disorder. Affiliated tissues include breast, lung and thymus, and related phenotypes are cellular and digestive/alimentary

Related Diseases for Basaloid Squamous Cell Carcinoma

Diseases related to Basaloid Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 596)
# Related Disease Score Top Affiliating Genes
1 cervical basaloid squamous cell carcinoma 32.9 KRT7 CDKN2A
2 esophageal basaloid squamous cell carcinoma 32.6 TP53 KRT14 EGFR
3 squamous cell papilloma 31.2 TP53 KRT14 CDKN2A
4 squamous cell carcinoma 31.1 TP63 TP53 KRT7 KRT19 EGFR CDKN2A
5 cloacogenic carcinoma 30.7 SYP ENO2
6 leiomyosarcoma 30.6 TP53 ENO2 CDKN2A
7 squamous cell carcinoma, head and neck 30.6 TP63 TP53 KRT19 EGFR CDKN2A
8 carcinosarcoma 30.5 TP53 KRT7 EGFR CDKN2A
9 olfactory neuroblastoma 30.5 SYP ENO2 CHGA
10 sinonasal undifferentiated carcinoma 30.4 SYP ENO2
11 anal canal paget's disease 30.4 KRT7 CDKN2A
12 penile cancer 30.3 TP53 EGFR CDKN2A
13 suppressor of tumorigenicity 3 30.3 TP53 CDKN2A
14 ameloblastoma 30.3 TP53 KRT8 KRT19 KRT14
15 papillary squamous carcinoma 30.2 SYP KRT7 EGFR CDKN2A
16 in situ carcinoma 30.2 TP53 KRT8 KRT17 KRT14 EGFR CDKN2A
17 pilomatrixoma 30.2 KRT17 KRT14 ENO2
18 carcinoid syndrome 30.1 SYP ENO2 CHGA
19 tongue squamous cell carcinoma 30.1 TP53 SOX2 EGFR CDKN2A
20 verrucous carcinoma 30.1 TP53 EGFR CDKN2A
21 oropharynx cancer 30.0 TP53 KRT7 KRT14 EGFR CDKN2A
22 adenoid squamous cell carcinoma 30.0 KRT8 KRT7 KRT20 KRT19
23 adenocarcinoma 30.0 TP53 KRT7 KRT20 EGFR CDKN2A
24 thymoma 29.9 TP63 TP53 SYP EGFR
25 adenoid cystic carcinoma 29.9 TP63 TP53 KRT7 KRT20 KRT19 KRT14
26 neuroendocrine carcinoma 29.8 TP63 SYP KRT7 KRT20 KRT19 ENO2
27 colorectal adenocarcinoma 29.8 TP53 KRT7 KRT20 EGFR CDKN2A
28 keratinizing squamous cell carcinoma 29.7 TP53 SYP KRT7 EGFR CDKN2A
29 ductal carcinoma in situ 29.6 TP53 KRT8 KRT14 EGFR CDKN2A
30 lung cancer susceptibility 3 29.5 TP53 KRT7 KRT20 KRT19 EGFR CDKN2A
31 oral cancer 29.5 TP53 KRT19 KRT13 EGFR CDKN2A
32 inverted papilloma 29.5 TP53 KRT7 KRT20 KRT13 EGFR CDKN2A
33 large cell neuroendocrine carcinoma 29.5 SYP KRT7 KRT20 ENO2 EGFR CHGA
34 neuroblastoma 29.4 TP53 SYP SOX2 ENO2 EGFR CHGA
35 lung squamous cell carcinoma 29.4 TP63 TP53 SOX2 KRT19 EGFR CDKN2A
36 mammary paget's disease 29.4 KRT8 KRT7 KRT20 KRT14 EGFR
37 adenosquamous carcinoma 29.3 TP63 TP53 SYP KRT8 KRT7 KRT19
38 cervical squamous cell carcinoma 29.3 TP63 TP53 SOX2 KRT8 KRT17 EGFR
39 lymphoepithelioma-like carcinoma 29.1 KRT8 KRT7 KRT20 KRT19 ENO2 EGFR
40 small cell carcinoma 29.0 TP53 SYP KRT8 KRT7 KRT20 KRT19
41 thymic carcinoma 28.8 TP63 TP53 SYP KRT7 KRT20 KRT19
42 teratoma 28.8 TP53 SYP SOX2 KRT7 KRT20 ENO2
43 papilloma 28.7 TP63 TP53 KRT8 KRT7 KRT20 KRT14
44 small cell cancer of the lung 28.7 TP53 SYP KRT7 KRT20 ENO2 EGFR
45 large cell carcinoma 28.7 TP63 SYP KRT7 KRT20 KRT19 ENO2
46 mucoepidermoid carcinoma 28.6 TP63 TP53 KRT7 KRT19 KRT14 KRT13
47 basal cell carcinoma 28.2 TP63 TP53 SYP SOX2 KRT8 KRT7
48 transitional cell carcinoma 28.2 TP63 TP53 KRT8 KRT7 KRT20 KRT19
49 skin carcinoma 27.8 TP53 SYP SOX2 KRT8 KRT7 KRT20
50 anus basaloid carcinoma 11.5

Graphical network of the top 20 diseases related to Basaloid Squamous Cell Carcinoma:



Diseases related to Basaloid Squamous Cell Carcinoma

Symptoms & Phenotypes for Basaloid Squamous Cell Carcinoma

MGI Mouse Phenotypes related to Basaloid Squamous Cell Carcinoma:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.21 CDKN2A EGFR ENO2 KRT14 KRT17 KRT19
2 digestive/alimentary MP:0005381 10.18 CDKN2A EGFR KRT13 KRT14 KRT17 KRT19
3 growth/size/body region MP:0005378 10.18 CDKN2A CHGA EGFR ENO2 KRT13 KRT14
4 craniofacial MP:0005382 10.15 EGFR ENO2 KRT13 KRT14 KRT17 KRT19
5 endocrine/exocrine gland MP:0005379 10.09 CDKN2A CHGA EGFR KRT14 KRT19 PGRMC2
6 embryo MP:0005380 10.06 CDKN2A EGFR KRT19 KRT8 PGRMC2 SOX2
7 integument MP:0010771 9.97 CDKN2A EGFR KRT14 KRT17 KRT19 SOX2
8 neoplasm MP:0002006 9.87 CDKN2A EGFR KRT14 KRT19 SOX2 TP53
9 no phenotypic analysis MP:0003012 9.86 CDKN2A CHGA EGFR KRT17 KRT19 SOX2
10 reproductive system MP:0005389 9.65 CDKN2A CHGA EGFR KRT14 KRT19 KRT8
11 pigmentation MP:0001186 9.63 CDKN2A EGFR KRT14 KRT17 SOX2 TP53
12 respiratory system MP:0005388 9.23 CDKN2A EGFR ENO2 KRT14 KRT19 SOX2

Drugs & Therapeutics for Basaloid Squamous Cell Carcinoma

Drugs for Basaloid Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2, Phase 3 946414-94-4
2 Antineoplastic Agents, Immunological Phase 3
3
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
4
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
5
Fluorouracil Approved Phase 2 51-21-8 3385
6
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
7
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
8
Cetuximab Approved Phase 2 205923-56-4 56842117 2333
9 Antibiotics, Antitubercular Phase 2
10 Alkylating Agents Phase 2
11 Mitomycins Phase 2
12 Anti-Bacterial Agents Phase 2
13 Tubulin Modulators Phase 2
14 Antimitotic Agents Phase 2
15 Albumin-Bound Paclitaxel Phase 2
16 Immunosuppressive Agents Phase 2
17 Antimetabolites Phase 2
18 Immunologic Factors Phase 2
19 Immunoglobulins Phase 2
20 Antibodies Phase 2
21 Immunoglobulins, Intravenous Phase 2
22 Antibodies, Monoclonal Phase 2
23
Panitumumab Approved, Investigational Phase 1 339177-26-3 50070211
24
Docetaxel Approved, Investigational Phase 1 114977-28-5 148124

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized Phase II/III Trial of De-Intensified Radiation Therapy for Patients With Early-Stage, P16-Positive, Non-Smoking Associated Oropharyngeal Cancer Recruiting NCT03952585 Phase 2, Phase 3 Cisplatin
2 A Randomized Phase III Study of Immune Checkpoint Inhibition With Chemotherapy in Treatment-Naïve Metastatic Anal Cancer Patients Recruiting NCT04444921 Phase 3 Carboplatin;Paclitaxel
3 A Randomized Phase III Study of Nivolumab After Combined Modality Therapy (CMT) in High Risk Anal Cancer Recruiting NCT03233711 Phase 3
4 A Randomized Phase II Study De-Intensified ChemoRadiation for Early-Stage Anal Squamous Cell Carcinoma (DECREASE) Recruiting NCT04166318 Phase 2 Capecitabine;Fluorouracil;Mitomycin
5 InterAACT - An International Multicentre Open Label Randomised Phase II Advanced Anal Cancer Trial Comparing Cisplatin Plus 5-Fluorouracil Versus Carboplatin Plus Weekly Paclitaxel in Patients With Inoperable Locally Recurrent or Metastatic Disease Active, not recruiting NCT02560298 Phase 2 Capecitabine;Carboplatin;Cisplatin;Fluorouracil;Paclitaxel
6 A Randomized, Phase II Study of Ficlatuzumab With or Without Cetuximab in Patients With Cetuximab-Resistant, Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma Active, not recruiting NCT03422536 Phase 2 Ficlatuzumab
7 Phase I Study Panitumumab Plus Chemoradiotherapy and Induction Chemotherapy in Patients With Locally Advanced Squamous Cell Cancer of the Head and Neck Completed NCT00513383 Phase 1 Panitumumab;Carboplatin;Paclitaxel;5-Fluorouracil;Docetaxel;Cisplatin

Search NIH Clinical Center for Basaloid Squamous Cell Carcinoma

Genetic Tests for Basaloid Squamous Cell Carcinoma

Anatomical Context for Basaloid Squamous Cell Carcinoma

MalaCards organs/tissues related to Basaloid Squamous Cell Carcinoma:

40
Breast, Lung, Thymus, Cervix, Skin, Prostate, Appendix

Publications for Basaloid Squamous Cell Carcinoma

Articles related to Basaloid Squamous Cell Carcinoma:

(show top 50) (show all 516)
# Title Authors PMID Year
1
Basaloid Squamous Cell Carcinoma of the Uterine Cervix: Report of a Case With Molecular Analysis. 61
33792431 2021
2
Cutaneous metastasis from esophageal basaloid squamous cell carcinoma: A case report. 61
33596520 2021
3
[Basaloid carcinoma of the left femur in a nonagenarian patient]. 61
33775430 2021
4
Beyond Squamous Cell Carcinoma: Basaloid Squamous Cell Carcinoma of the Esophagus. 61
33585108 2021
5
Basaloid squamous cell carcinoma of the uterine cervix coexisting with undifferentiated sarcoma. 61
33488332 2020
6
The importance of adjuvant treatment and primary anatomical site in head and neck basaloid squamous cell carcinoma survival: an analysis of the National Cancer Database. 61
32440914 2020
7
Glioma-Associated Oncogene-1 Expression in Basal Cell Carcinoma and Its Histologic Mimics. 61
33264133 2020
8
CYLD-mutant cylindroma-like basaloid carcinoma of the anus: a genetically and morphologically distinct class of HPV-related anal carcinoma. 61
32461623 2020
9
Revisiting a rare disease: Oral cavity basaloid squamous cell carcinoma at a high-volume tertiary center. 61
32682190 2020
10
Difference in characteristics and outcomes of basaloid squamous cell carcinoma and squamous cell carcinoma, usual type in cervix: A population-based study from SEER 18 database. 61
32573088 2020
11
Basaloid squamous cell carcinoma with adenoid cystic-like features of the head and neck region: A report of two cases. 61
32667090 2020
12
Coexistence of Basaloid Squamous Cell Carcinoma and Large Cell Neuroendocrine Carcinoma in the Larynx: A Case Report and Literature Review. 61
32921173 2020
13
Basaloid Nasopharyngeal Carcinoma: An Entity That Remains Oblivious. 61
33431368 2020
14
Laryngeal Squamous Cell Carcinoma with Osteosarcomatous Differentiation and Involvement of Thyroid Cartilage Mimicking Sarcoma Arising from Thyroid Cartilage. 61
31873935 2020
15
Pulmonary metastasectomy for esophageal basaloid squamous cell carcinoma component at 66 months after esophagectomy. 61
32757102 2020
16
Successful treatment of basaloid squamous cell carcinoma in the rectosigmoid colon: A case report and review of literature. 61
32775387 2020
17
The Utility of MYB Immunohistochemistry (IHC) in Fine Needle Aspiration (FNA) Diagnosis of Adenoid Cystic Carcinoma (AdCC). 61
32661670 2020
18
A rare case of nasal Schneiderian (inverted) papilloma associated with basaloid squamous cell carcinoma. 61
32534706 2020
19
Cetuximab and paclitaxel combination therapy for recurrent basaloid squamous cell carcinoma in the ethmoid sinus. 61
32684403 2020
20
[Basaloid squamous cell carcinoma in gingiva: a case report]. 61
32573146 2020
21
Characteristics of penile cancer in Japan: An analysis of nationwide hospital-based cancer registry data. 61
32307745 2020
22
Lung nuclear protein in testis carcinoma in an elderly Korean woman: A case report with cytohistological analysis. 61
32319714 2020
23
Basaloid squamous cell carcinoma of the breast. 61
32199592 2020
24
Survival comparison of Three histological subtypes of lung squamous cell carcinoma: A population-based propensity score matching analysis. 61
32062199 2020
25
Basaloid squamous cell carcinoma: a 31-year retrospective study and analysis of 214 cases reported in the literature. 61
31912260 2020
26
Histological subtype remains a prognostic factor for survival in nasopharyngeal carcinoma patients. 61
31188486 2020
27
A case of thymic basaloid carcinoma with rectal carcinoma. 61
32966925 2020
28
Cutaneous HPV16 and p16 Positive Basaloid Squamous Cell Carcinoma with Brain Metastasis: A Case Report. 61
32637111 2020
29
Comprehensive Molecular Characterizations of Chinese Patients With Different Subtypes of Lung Squamous Cell Carcinoma. 61
33363036 2020
30
Laryngeal Basaloid Squamous Cell Carcinoma with a Substantial Spindle Cell Component: Case Presentation and Updated Review of Literature. 61
29869750 2019
31
Esophageal Carcinosarcoma with Basaloid Squamous Cell Carcinoma: A Case Report and Review of the Literature. 61
31852851 2019
32
Primary Intra-Osseous Basaloid Squamous Cell Carcinoma of Mandible: Report of Rare Case with Proposed Diagnostic Criteria. 61
31839099 2019
33
Differential miRNA Expression in Basaloid Squamous Cell Carcinoma of the Oesophagus: miR-3687 Targets PGRMC2. 61
31810911 2019
34
Non-placement versus placement of a drainage tube around the cervical anastomosis in McKeown esophagectomy: study protocol for a randomized controlled trial. 61
31870427 2019
35
Basaloid nasopharyngeal carcinoma: A population-based analysis of a rare tumor. 61
30632158 2019
36
SOX10 Immunoexpression in Basaloid Squamous Cell Carcinomas: A Diagnostic Pitfall for Ruling out Salivary Differentiation. 61
30498968 2019
37
Thymic basaloid carcinoma: a rare clinical entity. 61
31780620 2019
38
Unusual Appearance of Basaloid SCC in Tonsil: A Case Report. 61
31742090 2019
39
Metastatic basaloid squamous cell carcinoma of thymic origin. 61
31570341 2019
40
Liver metastatic basaloid squamous cell carcinoma with negative expression of pancytokeratin: a case report and literature review. 61
31488173 2019
41
[Basaloid Squamous Cell Carcinoma;Report of a Case]. 61
31353361 2019
42
Differential expression of claudin‑4, occludin, SOX2 and proliferating cell nuclear antigen between basaloid squamous cell carcinoma and squamous cell carcinoma. 61
31257482 2019
43
HPV related cloacogenic carcinoma of the anal canal with divergent histomorphology. 61
31361242 2019
44
Human Papillomavirus-Independent Squamous Lesions of the Vulva. 61
31097103 2019
45
Association study of cell cycle proteins and human papillomavirus in laryngeal cancer in Chinese population. 61
30681775 2019
46
A Rare Case of Stage IV Basaloid Squamous Cell Cancer with Intrapulmonary and Brain Metastases. 61
31068568 2019
47
Endoscopic features and associated histology of an basaloid squamous cell carcinoma of the esophagus at the very early stage. 61
31142308 2019
48
Basaloid Squamous Cell Carcinoma of the Larynx: A National Cancer Database Analysis. 61
30717636 2019
49
Basaloid Squamous Cell Carcinoma of Tonsil: an Unusual and Aggressive Variant. 61
30948878 2019
50
Subcutaneous metastasis from recurrent basaloid squamous cell carcinoma of the esophagus. 61
29078709 2019

Variations for Basaloid Squamous Cell Carcinoma

Expression for Basaloid Squamous Cell Carcinoma

Search GEO for disease gene expression data for Basaloid Squamous Cell Carcinoma.

Pathways for Basaloid Squamous Cell Carcinoma

GO Terms for Basaloid Squamous Cell Carcinoma

Cellular components related to Basaloid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 10.06 TP53 SOX2 KRT8 KRT7 KRT20 KRT19
2 keratin filament GO:0045095 9.46 KRT8 KRT7 KRT14 KRT13
3 intermediate filament cytoskeleton GO:0045111 9.43 KRT8 KRT17 KRT13
4 cell periphery GO:0071944 9.26 KRT8 KRT19 KRT17 KRT14
5 intermediate filament GO:0005882 9.17 KRT8 KRT7 KRT20 KRT19 KRT17 KRT14

Biological processes related to Basaloid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.65 TP53 KRT8 KRT7 KRT19 EGFR
2 keratinization GO:0031424 9.5 KRT8 KRT7 KRT20 KRT19 KRT17 KRT14
3 replicative senescence GO:0090399 9.4 TP53 CDKN2A
4 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.37 TP53 EGFR
5 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 9.32 TP63 SOX2
6 cornification GO:0070268 9.17 KRT8 KRT7 KRT20 KRT19 KRT17 KRT14
7 cell differentiation involved in embryonic placenta development GO:0060706 9.16 KRT8 KRT19

Molecular functions related to Basaloid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 9.43 KRT20 KRT19 KRT14
2 structural molecule activity GO:0005198 9.35 KRT20 KRT19 KRT17 KRT14 KRT13
3 p53 binding GO:0002039 9.33 TP63 TP53 CDKN2A
4 MDM2/MDM4 family protein binding GO:0097371 8.8 TP63 TP53 CDKN2A

Sources for Basaloid Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....