MCID: BSL006
MIFTS: 44

Basaloid Squamous Cell Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Basaloid Squamous Cell Carcinoma

MalaCards integrated aliases for Basaloid Squamous Cell Carcinoma:

Name: Basaloid Squamous Cell Carcinoma 12 15 17 74
Basaloid Carcinoma 12 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:5522
NCIt 51 C54244

Summaries for Basaloid Squamous Cell Carcinoma

Disease Ontology : 12 A squamous cell carcinoma that has a solid, closely packed growth of cells with hyperchromatic nuclei, scant cytoplasm, small cystic spaces, and foci of necrosis. It has overlying squamous dysplasia, rare foci of overt keratinization, and/or coexistent keratinizing squamous cell carcinoma.

MalaCards based summary : Basaloid Squamous Cell Carcinoma, also known as basaloid carcinoma, is related to esophageal basaloid squamous cell carcinoma and adenoid cystic carcinoma. An important gene associated with Basaloid Squamous Cell Carcinoma is KRT14 (Keratin 14), and among its related pathways/superpathways are Developmental Biology and Cytoskeletal Signaling. The drugs Fluorouracil and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and cervix, and related phenotypes are craniofacial and digestive/alimentary

Related Diseases for Basaloid Squamous Cell Carcinoma

Diseases related to Basaloid Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 317)
# Related Disease Score Top Affiliating Genes
1 esophageal basaloid squamous cell carcinoma 34.0 EGFR KRT14 TP53
2 adenoid cystic carcinoma 30.7 KRT14 KRT7 TP53
3 suppressor of tumorigenicity 3 30.4 CDKN2A TP53
4 keratinizing squamous cell carcinoma 30.4 CDKN2A TP53
5 penile cancer 30.1 CDKN2A EGFR TP53
6 basal cell carcinoma 30.0 KRT17 KRT7 KRT8 TP53
7 inverted papilloma 29.8 CDKN2A KRT13 KRT7 TP53
8 mucoepidermoid carcinoma 29.7 EGFR KRT13 KRT14 KRT7
9 small cell carcinoma 29.6 CDKN2A EGFR ENO2 KRT7 SYP TP53
10 in situ carcinoma 29.2 CDKN2A EGFR KRT14 KRT17 TP53
11 papilloma 29.0 CDKN2A KRT13 KRT14 KRT7 KRT8 TP53
12 small cell cancer of the lung 28.9 CDKN2A EGFR ENO2 KRT7 SYP TP53
13 lung cancer 28.4 CDKN2A EGFR ENO2 KRT7 SYP TP53
14 cervical basaloid squamous cell carcinoma 12.4
15 anus basaloid carcinoma 12.4
16 vulvar basaloid squamous cell carcinoma 12.4
17 thymus basaloid carcinoma 12.4
18 penis basaloid carcinoma 12.2
19 basaloid squamous cell skin carcinoma 11.4
20 squamous cell carcinoma 11.2
21 squamous cell carcinoma, head and neck 10.7
22 breast benign neoplasm 10.4 KRT14 TP53
23 thoracic benign neoplasm 10.4 KRT14 TP53
24 fibroepithelial basal cell carcinoma 10.4 KRT14 TP53
25 supraglottis cancer 10.4 ENO2 TP53
26 basal cell carcinoma 1 10.4
27 liver angiosarcoma 10.4 ENO2 TP53
28 sweat gland disease 10.4 KRT14 KRT7
29 appendix cancer 10.4 KRT7 TP53
30 lipoadenoma 10.4 KRT14 KRT7
31 papillary serous adenocarcinoma 10.4 KRT7 TP53
32 female reproductive endometrioid cancer 10.4 KRT7 TP53
33 acinar cell carcinoma 10.4 KRT7 TP53
34 pseudomyxoma peritonei 10.4 KRT7 TP53
35 biliary papillomatosis 10.4 KRT7 TP53
36 duodenum cancer 10.4 ENO2 KRT7
37 chondroid lipoma 10.4 ENO2 KRT7
38 pericardium cancer 10.4 ENO2 KRT7
39 malignant spiradenoma 10.4 KRT7 TP53
40 thyroid lymphoma 10.4 CDKN2A TP53
41 papillary transitional carcinoma 10.4 ENO2 KRT7
42 anogenital venereal wart 10.4 CDKN2A TP53
43 penile disease 10.4 CDKN2A TP53
44 megaesophagus 10.4 CDKN2A TP53
45 vulvar intraepithelial neoplasia 10.4 KRT7 TP53
46 scrotal carcinoma 10.4 CDKN2A TP53
47 verrucous carcinoma 10.4 CDKN2A TP53
48 bladder squamous cell carcinoma 10.4 CDKN2A TP53
49 ameloblastic carcinoma 10.4 CDKN2A KRT14
50 anal squamous cell carcinoma 10.4 CDKN2A TP53

Graphical network of the top 20 diseases related to Basaloid Squamous Cell Carcinoma:



Diseases related to Basaloid Squamous Cell Carcinoma

Symptoms & Phenotypes for Basaloid Squamous Cell Carcinoma

MGI Mouse Phenotypes related to Basaloid Squamous Cell Carcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.55 EGFR ENO2 KRT14 KRT17 TP53
2 digestive/alimentary MP:0005381 9.43 CDKN2A EGFR KRT14 KRT17 KRT8 TP53
3 pigmentation MP:0001186 9.02 CDKN2A EGFR KRT14 KRT17 TP53

Drugs & Therapeutics for Basaloid Squamous Cell Carcinoma

Drugs for Basaloid Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 3,Phase 2,Phase 1 51-21-8 3385
2
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 2767 441203 84093
3
nivolumab Approved Phase 2, Phase 3 946414-94-4
4 Antimetabolites, Antineoplastic Phase 3,Phase 2,Phase 1
5 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
6 Immunologic Factors Phase 3,Phase 2,Phase 1
7 Antimetabolites Phase 3,Phase 2,Phase 1
8 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
9 Alkylating Agents Phase 3,Phase 2
10 Anti-Bacterial Agents Phase 3,Phase 2
11 Mitomycins Phase 3,Phase 2
12 Antibiotics, Antitubercular Phase 3,Phase 2
13 Antineoplastic Agents, Immunological Phase 2, Phase 3,Phase 1
14
Cetuximab Approved Phase 2,Phase 1 205923-56-4 56842117 2333
15
Paclitaxel Approved, Vet_approved Phase 2,Phase 1 33069-62-4 36314
16
Carboplatin Approved Phase 2,Phase 1 41575-94-4 10339178 38904 498142
17
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
18
Ipilimumab Approved Phase 2 477202-00-9
19 Albumin-Bound Paclitaxel Phase 2,Phase 1
20 Antibodies Phase 2
21 Antibodies, Monoclonal Phase 2
22 Immunoglobulins Phase 2
23 Antineoplastic Agents, Phytogenic Phase 2,Phase 1
24 Antimitotic Agents Phase 2,Phase 1
25
Panitumumab Approved, Investigational Phase 1 339177-26-3 50070211
26
Docetaxel Approved, Investigational Phase 1 114977-28-5 148124

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer Unknown status NCT00003652 Phase 3 cisplatin;fluorouracil
2 Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer Completed NCT00003596 Phase 3 cisplatin;fluorouracil;mitomycin C
3 Radiation Therapy Plus Fluorouracil With or Without Additional Chemotherapy in Treating Patients With Primary Anal Cancer Completed NCT00025090 Phase 3 cisplatin;fluorouracil;mitomycin C
4 De-intensified Radiation Therapy With Chemotherapy (Cisplatin) or Immunotherapy (Nivolumab) in Treating Patients With Early-Stage, HPV-Positive, Non-Smoking Associated Oropharyngeal Cancer Not yet recruiting NCT03952585 Phase 2, Phase 3 Cisplatin
5 Intensity-Modulated Radiation Therapy, Fluorouracil, and Mitomycin C in Treating Patients With Invasive Anal Cancer Completed NCT00423293 Phase 2 fluorouracil;mitomycin C
6 Combined Modality Therapy for Patients With With HIV and Stage I, Stage II, or Stage III Anal Cancer Completed NCT00324415 Phase 2 cisplatin;fluorouracil
7 Nivolumab After Combined Modality Therapy in Treating Patients With High Risk Stage II-IIIB Anal Cancer Recruiting NCT03233711 Phase 2
8 Ficlatuzumab w/wo Cetuximab in Patients w/Cetuximab-Resistant, Recurrent or Metastatic Head/Neck Squamous Cell Carcinoma Recruiting NCT03422536 Phase 2 Ficlatuzumab
9 Cisplatin and Fluorouracil Compared With Carboplatin and Paclitaxel in Treating Patients With Inoperable Locally Recurrent or Metastatic Anal Cancer Active, not recruiting NCT02560298 Phase 2 Capecitabine;Carboplatin;Cisplatin;Fluorouracil;Paclitaxel
10 Cetuximab, Cisplatin, Fluorouracil, and Radiation Therapy in Treating Patients With Anal Cancer Active, not recruiting NCT00316888 Phase 2 cisplatin;fluorouracil
11 Ipilimumab, Nivolumab, and Radiation Therapy in Treating Patients With HPV Positive Advanced Oropharyngeal Squamous Cell Carcinoma Not yet recruiting NCT03799445 Phase 2
12 Abraxane in Combination With Carboplatin, Erbitux and IMRT for Locally Advanced Squamous Cancer of the Head and Neck Terminated NCT00570674 Phase 1, Phase 2 Abraxane;Erbitux;Carboplatin
13 Panitumumab Chemoradiotherapy Chemotherapy for Squamous Cancer of the Head and Neck Completed NCT00513383 Phase 1 Panitumumab;Carboplatin;Paclitaxel;5-Fluorouracil;Docetaxel;Cisplatin

Search NIH Clinical Center for Basaloid Squamous Cell Carcinoma

Genetic Tests for Basaloid Squamous Cell Carcinoma

Anatomical Context for Basaloid Squamous Cell Carcinoma

MalaCards organs/tissues related to Basaloid Squamous Cell Carcinoma:

42
Lung, Breast, Cervix, Thymus, Skin, Tongue, Prostate

Publications for Basaloid Squamous Cell Carcinoma

Articles related to Basaloid Squamous Cell Carcinoma:

(show top 50) (show all 264)
# Title Authors Year
1
Basaloid Squamous Cell Carcinoma of the Larynx: A National Cancer Database Analysis. ( 30717636 )
2019
2
A comparative analysis of clinicopathological factors between esophageal small cell and basaloid squamous cell carcinoma. ( 30813135 )
2019
3
Basaloid Squamous Cell Carcinoma of Tonsil: an Unusual and Aggressive Variant. ( 30948878 )
2019
4
Clinical characteristics and prognosis of basaloid squamous cell carcinoma of the lung: a population-based analysis. ( 31106047 )
2019
5
A Limited Immunohistochemical Panel to Distinguish Basal Cell Carcinoma of Cutaneous Origin From Basaloid Squamous Cell Carcinoma of the Head and Neck. ( 27438511 )
2018
6
Metastatic primary cutaneous basaloid squamous cell carcinoma: transformation after 20 years of neglect. ( 26336073 )
2018
7
Pulmonary Basaloid Squamous Cell Carcinoma in a Dog. ( 29598999 )
2018
8
Basaloid squamous cell carcinoma: Report of two cases with review of literature. ( 29731566 )
2018
9
Laryngeal Basaloid Squamous Cell Carcinoma with a Substantial Spindle Cell Component: Case Presentation and Updated Review of Literature. ( 29869750 )
2018
10
Basaloid squamous cell carcinoma - A rare and aggressive variant of squamous cell carcinoma: A case report and review of literature. ( 29937662 )
2018
11
Basaloid squamous cell carcinoma: Report of two rare cases and review of literature. ( 30158794 )
2018
12
Unusual metastatic localization to the kidney of basaloid squamous cell carcinoma of the oropharynx. ( 30426881 )
2018
13
Basaloid squamous cell carcinoma arising in an inverted papilloma in the nasal cavity: A case report and review. ( 27720480 )
2017
14
Bilateral Basaloid Squamous Cell Carcinoma of the Parotid Gland: A Case Report and Review of the Literature. ( 28333602 )
2017
15
Basaloid Squamous Cell Carcinoma of Tongue: A Report with Emphasis on Immunohistochemistry. ( 28511524 )
2017
16
Cytomorphology of Basaloid Squamous Cell Carcinoma: A Diagnostic Dilemma. ( 28571158 )
2017
17
Basaloid Squamous Cell Carcinoma of the Head and Neck: Subclassification into Basal, Ductal, and Mixed Subtypes Based on Comparison of Clinico-pathologic Features and Expression of p53, Cyclin D1, Epidermal Growth Factor Receptor, p16, and Human Papillomavirus. ( 28593937 )
2017
18
A novel gene expression scoring system for accurate diagnosis of basaloid squamous cell carcinoma of the esophagus. ( 28731134 )
2017
19
Clinicopahological features of superficial basaloid squamous cell carcinoma of the esophagus. ( 28881881 )
2017
20
A Case of Basaloid Squamous Cell Carcinoma of Polypoid Type in the Esophagus. ( 29033778 )
2017
21
Subcutaneous metastasis from recurrent basaloid squamous cell carcinoma of the esophagus. ( 29078709 )
2017
22
A long-surviving patient with advanced esophageal basaloid squamous cell carcinoma treated only with radiotherapy: case report and literature review. ( 29216832 )
2017
23
Aggressiveness pattern and second primary tumor risk associated with basaloid squamous cell carcinoma of the larynx. ( 29221167 )
2017
24
Basaloid Squamous Cell Carcinoma of the Lung Associated With Syndrome of Inappropriate Antidiuretic Hormone Secretion. ( 29317964 )
2017
25
Basaloid Squamous Cell Carcinoma of the Anus Revisited. ( 26866355 )
2016
26
Basaloid Squamous Cell Carcinoma of Scalp From A Pre-Existing Cylindroma Metastasising To Brain: A Rare Case Report. ( 27437239 )
2016
27
Basaloid squamous cell carcinoma of oral cavity: Report of two cases. ( 27721627 )
2016
28
Soft Tissue Reconstruction for Basaloid Squamous Cell Carcinoma on the Hemiface. ( 27896203 )
2016
29
The Preoperative Neutrophil-To-Lymphocyte Ratio Is a Novel Immune Parameter for the Prognosis of Esophageal Basaloid Squamous Cell Carcinoma. ( 27959959 )
2016
30
Basaloid squamous cell carcinoma of the mandible. ( 30894957 )
2016
31
Neural Axis Metastasis from Metachronous Pulmonary Basaloid Carcinoma Developed after Chemotherapy & Radiation Therapy of Uterine Cervical Carcinoma. ( 27857930 )
2016
32
[Cytology of basaloid squamous cell carcinoma and small cell carcinoma of lung: a comparative study]. ( 27033386 )
2016
33
Basal cell carcinoma vs basaloid squamous cell carcinoma of the skin: an immunohistochemical reappraisal. ( 25702956 )
2015
34
Basaloid squamous cell carcinoma of the maxilla. ( 26055591 )
2015
35
Basaloid Squamous Cell Carcinoma: An Unusual Ball-Valve Laryngeal Obstruction. ( 26082908 )
2015
36
Basaloid squamous cell carcinoma of cervix showing neuroendocrine differentiation. ( 26148627 )
2015
37
Basaloid Squamous Cell Carcinoma of the Sigmoid Colon. ( 26157950 )
2015
38
Basaloid squamous cell carcinoma of the uterine cervix: Cytological and histological features. ( 26391899 )
2015
39
Basaloid Squamous Cell Carcinoma on the Skin of the Hand. ( 26618138 )
2015
40
Surgical resection and chemoradiotherapy for metachronous pulmonary metastasis of basaloid squamous cell carcinoma of the oesophagus. ( 26629851 )
2015
41
Basaloid Squamous Cell Carcinoma of the Ethmoid Sinus with Invasion into the Skull Base Treated with Craniofacial Resection and Adjuvant Intensity-Modulated Radiation Therapy: A Case Report. ( 26835192 )
2015
42
Basaloid squamous cell carcinoma of the conjunctiva. ( 24481508 )
2015
43
Human papillomavirus-related basaloid squamous cell carcinoma of the bladder associated with genital tract human papillomavirus infection. ( 25236950 )
2015
44
Editorial comment to Human papillomavirus-related basaloid squamous cell carcinoma of the bladder associated with genital tract human papillomavirus infection. ( 25376368 )
2015
45
PTCH1 mutation is a frequent event in oesophageal basaloid squamous cell carcinoma. ( 25395299 )
2015
46
Basaloid squamous cell carcinoma of the sinonasal tract with metastasis to the liver: a case report and literature review. ( 25651356 )
2015
47
Molecular Characteristics of Basaloid Squamous Cell Carcinoma of the Esophagus: Analysis of KRAS, BRAF, and PIK3CA Mutations and LINE-1 Methylation. ( 25691283 )
2015
48
Basaloid squamous cell carcinoma of the maxilla: Report of a case and literature review. ( 25798549 )
2015
49
Surgical management in a rare case of basaloid squamous cell carcinoma of the maxilla. ( 25914753 )
2015
50
Molecular pathology and potential therapeutic targets in esophageal basaloid squamous cell carcinoma. ( 26045734 )
2015

Variations for Basaloid Squamous Cell Carcinoma

Expression for Basaloid Squamous Cell Carcinoma

Search GEO for disease gene expression data for Basaloid Squamous Cell Carcinoma.

Pathways for Basaloid Squamous Cell Carcinoma

GO Terms for Basaloid Squamous Cell Carcinoma

Cellular components related to Basaloid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.97 CDKN2A ENO2 KRT13 KRT14 KRT17 KRT7
2 extracellular exosome GO:0070062 9.8 ENO2 KRT13 KRT14 KRT17 KRT7 KRT8
3 cell periphery GO:0071944 9.43 KRT14 KRT17 KRT8
4 intermediate filament cytoskeleton GO:0045111 9.33 KRT13 KRT17 KRT8
5 keratin filament GO:0045095 9.26 KRT13 KRT14 KRT7 KRT8
6 intermediate filament GO:0005882 9.02 KRT13 KRT14 KRT17 KRT7 KRT8

Biological processes related to Basaloid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 epidermis development GO:0008544 9.43 EGFR KRT14 KRT17
2 keratinization GO:0031424 9.35 KRT13 KRT14 KRT17 KRT7 KRT8
3 replicative senescence GO:0090399 9.32 CDKN2A TP53
4 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.16 EGFR TP53
5 cornification GO:0070268 9.02 KRT13 KRT14 KRT17 KRT7 KRT8

Molecular functions related to Basaloid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 8.62 KRT13 KRT17

Sources for Basaloid Squamous Cell Carcinoma

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