MCID: BSL006
MIFTS: 40

Basaloid Squamous Cell Carcinoma

Categories: Cancer diseases, Skin diseases
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Aliases & Classifications for Basaloid Squamous Cell Carcinoma

MalaCards integrated aliases for Basaloid Squamous Cell Carcinoma:

Name: Basaloid Squamous Cell Carcinoma 11 14 16 71
Basaloid Carcinoma 11 16 71

Classifications:



External Ids:

Disease Ontology 11 DOID:5522
NCIt 49 C54244
SNOMED-CT 68 128634009
UMLS 71 C1266005 C1704216

Summaries for Basaloid Squamous Cell Carcinoma

Disease Ontology: 11 A squamous cell carcinoma that has a solid, closely packed growth of cells with hyperchromatic nuclei, scant cytoplasm, small cystic spaces, and foci of necrosis. It has overlying squamous dysplasia, rare foci of overt keratinization, and/or coexistent keratinizing squamous cell carcinoma.

MalaCards based summary: Basaloid Squamous Cell Carcinoma, also known as basaloid carcinoma, is related to cervical basaloid squamous cell carcinoma and thymus basaloid carcinoma. An important gene associated with Basaloid Squamous Cell Carcinoma is KRT5 (Keratin 5), and among its related pathways/superpathways are Neuroscience and Cytoskeletal Signaling. The drugs Carboplatin and Paclitaxel have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and cervix, and related phenotypes are growth/size/body region and digestive/alimentary

Related Diseases for Basaloid Squamous Cell Carcinoma

Diseases related to Basaloid Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 693)
# Related Disease Score Top Affiliating Genes
1 cervical basaloid squamous cell carcinoma 32.9 KRT7 CDKN2A
2 thymus basaloid carcinoma 32.5 SYP NKX2-1 KRT5
3 anus basaloid carcinoma 31.9 SYP PTGER4 KRT7 KRT5 KIT CDKN2A
4 squamous cell carcinoma 31.6 TP53 NKX2-1 KRT7 KRT14 CDKN2A
5 adenoid cystic carcinoma 30.8 TP53 NCAM1 KRT7 KRT14 KIT CDKN2A
6 inverted papilloma 30.8 TP53 KRT5 CDKN2A
7 penile benign neoplasm 30.7 TP53 CDKN2A
8 lip and oral cavity cancer 30.7 TP53 KIT CDKN2A
9 skin squamous cell carcinoma 30.7 TP53 KRT5 KRT14 CDKN2A
10 trachea carcinoma 30.6 NKX2-1 KRT7 KRT5
11 eccrine porocarcinoma 30.6 NUTM1 KRT7 KRT5
12 mucoepidermoid carcinoma 30.5 KRT8 KRT7 KRT14
13 conjunctival squamous cell carcinoma 30.5 TP53 CDKN2A
14 carcinosarcoma 30.4 TP53 SYP KRT7 KIT CDKN2A
15 cloacogenic carcinoma 30.4 SYP KRT5 ENO2
16 anal canal paget's disease 30.3 KRT7 CDKN2A
17 papilloma 30.3 TP53 KRT8 KRT7 KRT5 KRT14 CDKN2A
18 salivary gland adenoid cystic carcinoma 30.3 TP53 KRT7 KRT5 KIT
19 germ cell cancer 30.3 TP53 KIT ENO2
20 basosquamous carcinoma 30.3 TP53 PTGER4 KRT7
21 myoma 30.3 TP53 KIT ENO2
22 suppressor of tumorigenicity 3 30.2 TP53 CDKN2A
23 neuroendocrine carcinoma 30.1 SYP NKX2-1 NCAM1 KRT7 KIT ENO2
24 ameloblastoma 30.1 TP53 KRT8 KRT14
25 keratoacanthoma 30.1 TP53 KRT8 KRT17 KRT14
26 carcinoid tumors, intestinal 30.1 SYP NKX2-1 ENO2 CHGA
27 pilomatrixoma 30.1 KRT5 KRT17 KRT14 ENO2
28 leiomyosarcoma 30.1 TP53 KIT ENO2 CDKN2A
29 cervical squamous cell carcinoma 30.1 TP53 KRT8 KRT17 KRT14 CDKN2A
30 adenoid squamous cell carcinoma 30.1 TP53 KRT8 KRT7 KRT5
31 carcinoid syndrome 30.0 SYP ENO2 CHGA
32 thymus cancer 30.0 TP53 NKX2-1 KRT7 KRT5 KIT
33 verrucous carcinoma 30.0 TP53 KRT5 KRT14 CDKN2A
34 olfactory neuroblastoma 29.9 SYP NUTM1 NCAM1 ENO2 CHGA
35 oropharynx cancer 29.9 TP53 KRT7 KRT5 KRT14 KIT CDKN2A
36 thymic carcinoma 29.9 SYP NUTM1 NKX2-1 KRT7 KRT5 KIT
37 cervix carcinoma 29.8 TP53 KRT7 INSM1 CDKN2A
38 thymoma 29.8 TP53 SYP NKX2-1 KRT7 KIT CDKN2A
39 adenocarcinoma 29.8 TP53 NKX2-1 NAPSA KRT7 CHGA CDKN2A
40 adenosquamous carcinoma 29.5 NKX2-1 KRT8 KRT7 KRT5 INSM1 CHGA
41 small cell carcinoma 29.4 TP53 SYP NKX2-1 NCAM1 NAPSA KRT7
42 sinonasal undifferentiated carcinoma 29.3 SYP NUTM1 NCAM1 KRT7 KRT5 ENO2
43 lung cancer susceptibility 3 29.3 TP53 NKX2-1 NAPSA KRT8 KRT7 CDKN2A
44 ewing sarcoma 29.3 TP53 SYP NUTM1 NCAM1 KIT ENO2
45 skin carcinoma 29.2 TP53 SYP KRT8 KRT7 KRT5 KRT14
46 ductal carcinoma in situ 29.2 TP53 KRT8 KRT5 KRT17 KRT14 CDKN2A
47 lung benign neoplasm 29.2 TP53 SYP NKX2-1 NCAM1 KRT7 ENO2
48 basal cell carcinoma 29.1 TP53 SYP PTGER4 KRT8 KRT7 KRT5
49 large cell carcinoma 29.1 TP53 SYP NKX2-1 NAPSA KRT7 KRT5
50 keratinizing squamous cell carcinoma 29.0 TP53 SYP NUTM1 NKX2-1 NAPSA KRT7

Graphical network of the top 20 diseases related to Basaloid Squamous Cell Carcinoma:



Diseases related to Basaloid Squamous Cell Carcinoma

Symptoms & Phenotypes for Basaloid Squamous Cell Carcinoma

MGI Mouse Phenotypes related to Basaloid Squamous Cell Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.13 CDKN2A CHGA ENO2 INSM1 KIT KRT14
2 digestive/alimentary MP:0005381 9.91 CDKN2A INSM1 KIT KRT14 KRT17 KRT5
3 pigmentation MP:0001186 9.77 CDKN2A KIT KRT14 KRT17 TP53
4 cellular MP:0005384 9.73 CDKN2A ENO2 INSM1 KIT KRT14 KRT17
5 craniofacial MP:0005382 9.7 ENO2 INSM1 KIT KRT14 KRT17 KRT5
6 respiratory system MP:0005388 9.23 CDKN2A ENO2 INSM1 KIT KRT14 NKX2-1

Drugs & Therapeutics for Basaloid Squamous Cell Carcinoma

Drugs for Basaloid Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 3 41575-94-4 10339178 38904
2
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
3
Nivolumab Approved Phase 3 946414-94-4
4 Albumin-Bound Paclitaxel Phase 3
5 Antimitotic Agents Phase 3
6 Tubulin Modulators Phase 3
7 Antineoplastic Agents, Immunological Phase 3
8 Immune Checkpoint Inhibitors Phase 3
9
Ipilimumab Approved Phase 2 477202-00-9
10
Mitomycin Approved Phase 2 50-07-7 5746
11
Cisplatin Approved Phase 2 15663-27-1 2767 5702198 441203
12
Fluorouracil Approved Phase 2 51-21-8 3385
13
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
14
Cetuximab Approved Phase 1, Phase 2 205923-56-4
15 Immunoglobulins, Intravenous Phase 2
16 Immunoglobulins Phase 2
17 Antibodies, Monoclonal Phase 2
18 Antibodies Phase 2
19 Anti-Bacterial Agents Phase 2
20 Alkylating Agents Phase 2
21 Antibiotics, Antitubercular Phase 2
22 Antimetabolites Phase 2
23 Immunosuppressive Agents Phase 2
24 Immunologic Factors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized Phase II/III Trial of De-Intensified Radiation Therapy for Patients With Early-Stage, P16-Positive, Non-Smoking Associated Oropharyngeal Cancer Recruiting NCT03952585 Phase 2, Phase 3 Cisplatin
2 A Randomized Phase III Study of Immune Checkpoint Inhibition With Chemotherapy in Treatment-Na�ve Metastatic Anal Cancer Patients Recruiting NCT04444921 Phase 3 Carboplatin;Paclitaxel
3 A Randomized Phase III Study of Nivolumab After Combined Modality Therapy (CMT) in High Risk Anal Cancer Active, not recruiting NCT03233711 Phase 3
4 A Randomized, Phase II Study of Ficlatuzumab With or Without Cetuximab in Patients With Cetuximab-Resistant, Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma Completed NCT03422536 Phase 2 Ficlatuzumab
5 Phase 2 Study (With Safety Lead in) of the Safety, Tolerability and Efficacy of Anti-CTLA4 (Ipilimumab) and Anti-PD-1 (Nivolumab) in Combination With Radiation Therapy to 50-66 Gy in Low-Intermediate Volume, Local-Regionally Advanced HPV-Positive Oropharyngeal Squamous Cell Carcinoma (OPSCC) Recruiting NCT03799445 Phase 2
6 A Randomized Phase II Study De-Intensified ChemoRadiation for Early-Stage Anal Squamous Cell Carcinoma (DECREASE) Recruiting NCT04166318 Phase 2 Capecitabine;Fluorouracil;Mitomycin
7 Risk-Adapted Therapy for HIV-Associated Anal Cancer Recruiting NCT04929028 Phase 2 Capecitabine;Fluorouracil;Mitomycin
8 InterAACT - An International Multicentre Open Label Randomised Phase II Advanced Anal Cancer Trial Comparing Cisplatin Plus 5-Fluorouracil Versus Carboplatin Plus Weekly Paclitaxel in Patients With Inoperable Locally Recurrent or Metastatic Disease Active, not recruiting NCT02560298 Phase 2 Capecitabine;Carboplatin;Cisplatin;Fluorouracil;Paclitaxel
9 A Phase I/II Trial of Abraxane in Combination With Carboplatin, Erbitux and Intensity Modulated Radiation Therapy (IMRT)for Treatment of Locally Advanced Squamous Cancer of the Head and Neck Terminated NCT00570674 Phase 1, Phase 2 Abraxane;Erbitux;Carboplatin

Search NIH Clinical Center for Basaloid Squamous Cell Carcinoma

Genetic Tests for Basaloid Squamous Cell Carcinoma

Anatomical Context for Basaloid Squamous Cell Carcinoma

Organs/tissues related to Basaloid Squamous Cell Carcinoma:

MalaCards : Skin, Lung, Cervix, Salivary Gland, Prostate, Colon, Tonsil

Publications for Basaloid Squamous Cell Carcinoma

Articles related to Basaloid Squamous Cell Carcinoma:

(show top 50) (show all 562)
# Title Authors PMID Year
1
Large cell neuroendocrine carcinoma of the floor of mouth and retromolar trigone in association with basaloid squamous cell carcinoma. 62
35523694 2022
2
Integrated molecular characterization of esophageal basaloid squamous cell carcinoma: a subtype with distinct RNA expression pattern and immune characteristics, but no specific genetic mutations. 62
36371676 2022
3
Survival comparison of different histological subtypes of oropharyngeal squamous cell carcinoma: A propensity-matched score analysis based on SEER database. 62
36317416 2022
4
Metachronous Primary Lung Cancer Occurring during the Spontaneous Regression of Locally Advanced Lung Cancer: A Rare Case Report. 62
36198568 2022
5
POU2F3 in SCLC: Clinicopathologic and Genomic Analysis With a Focus on Its Diagnostic Utility in Neuroendocrine-Low SCLC. 62
35760287 2022
6
Clinicopathological and mutational analysis of esophageal basaloid squamous cell carcinoma. 62
35641667 2022
7
Basaloid Squamous Cell Carcinoma, an Aggressive and Rare Cancer of the Oral Cavity: Can We Prevent It at the Primary Care Setting? 62
36225467 2022
8
A case of finger metastasis from esophageal basaloid squamous cell carcinoma. 62
34813081 2022
9
A diagnostic pitfall; Small cell carcinoma-like features in basaloid squamous cell carcinoma of the esophagus. 62
35861388 2022
10
Coexistence of Basaloid Squamous Cell Carcinoma and Large Cell Neuroendocrine Carcinoma in the Larynx: A Case Report and Literature Review. 62
32921173 2022
11
Ovarian Low-grade Basaloid Carcinoma Arising in Brenner Tumor: A New Variant of Malignant Brenner Tumor. 62
34015796 2022
12
Neuroendocrine differentiation distinguishes basaloid variant of lung squamous cell carcinoma. 62
35538551 2022
13
Analysis of Human Papillomavirus (HPV) and Polyomaviruses (HPyVs) in Adenoid Cystic Carcinoma (AdCC) of the Head and Neck Region Reveals Three HPV-Positive Cases with Adenoid Cystic-like Features. 62
35632780 2022
14
Basaloid squamous cell carcinoma of anal canal with adenoid cystic pattern and liver metastasis: A rare case report. 62
34931759 2022
15
CT findings of basaloid squamous cell carcinoma of the lung in 12 patients: A distinct category of squamous cell carcinoma in 2015 WHO classification of lung tumors. 62
35583530 2022
16
Oral basaloid squamous cell carcinoma: A case report with emphasis on histopathological diagnosis criteria. 62
35279544 2022
17
Prolonged Response of Metastatic Programmed Death-Ligand 1 (PD-L1) Negative Basaloid Squamous Cell Carcinoma of the Lung to Maintenance Immunotherapy. 62
35619841 2022
18
Basaloid squamous cell carcinoma of the hypopharynx: an analysis of 213 cases. 62
34319483 2022
19
A right pulmonary vein abnormality treated with 3D CT assistance in thoracoscopic surgery for esophageal cancer: a case report. 62
35294660 2022
20
[Clinicopathological study in 28 cases of oral basaloid squamous cell carcinomas]. 62
35165469 2022
21
Basaloid squamous cell carcinoma with prominent shadow (ghost) cell differentiation. An unreported neoplasm of the parotid gland. 62
36074688 2022
22
Diagnostic and Therapeutic Challenges in a Patient with Synchronous Very High-Risk Prostate Adenocarcinoma and Anal Carcinoma. 62
35049707 2022
23
PD-1 inhibitor therapy of basal cell carcinoma with pulmonary metastasis. 62
34855248 2022
24
Primary basaloid squamous cell carcinoma of the parotid gland mimicking metastasis of basal cell carcinoma of the contralateral periorbital region: case report. 62
35242692 2022
25
Solid Carcinoma of the Canine Mammary Gland: a Histological Type or Tumour Cell Arrangement? 62
35152966 2022
26
Transoral laryngeal microsurgery for early-stage laryngeal basaloid squamous cell carcinoma. 62
34969794 2021
27
Cetuximab and paclitaxel combination therapy for recurrent basaloid squamous cell carcinoma in the ethmoid sinus. 62
32684403 2021
28
Surgical management of locally invasive basaloid carcinoma of thymic gland. 62
34858582 2021
29
[Basaloid carcinoma of the left femur in a nonagenarian patient]. 62
33775430 2021
30
Esophageal basaloid squamous cell carcinoma presenting as a subepithelial lesion. 62
34224084 2021
31
Basaloid Squamous Cell Carcinoma of the Uterine Cervix: Report of a Case With Molecular Analysis. 62
33792431 2021
32
Adenoid cystic carcinoma and basaloid carcinoma of the breast: A clinicopathological study. 62
34544554 2021
33
Glioma-Associated Oncogene-1 Expression in Basal Cell Carcinoma and Its Histologic Mimics. 62
33264133 2021
34
NUT carcinoma of the lung. 62
34176698 2021
35
Basaloid squamous cell carcinoma. 62
35281164 2021
36
Cervical carcinoma with histologic components of sarcomatoid carcinoma and multiple basaloid variants: A case report and review of the literature. 62
34124329 2021
37
Constitutive Hedgehog/GLI2 signaling drives extracutaneous basaloid squamous cell carcinoma development and bone remodeling. 62
34117865 2021
38
Comedo-like skin metastases in cervical carcinoma. 62
34279858 2021
39
Basaloid squamous cell carcinoma in the maxillary gingiva. 62
34528572 2021
40
Sequential treatment from mandibulectomy to reconstruction on mandibular oral cancer - Case review II: mandibular anterior and the floor of the mouth lesion of basaloid squamous cell carcinoma and clear cell odontogenic carcinoma. 62
34187962 2021
41
[Clinicopathological features of basal cell type dysplasia of esophagus]. 62
34078053 2021
42
Mediastinal basaloid carcinoma arising from thymic cysts in two dogs. 62
33814518 2021
43
The Utility of MYB Immunohistochemistry (IHC) in Fine Needle Aspiration (FNA) Diagnosis of Adenoid Cystic Carcinoma (AdCC). 62
32661670 2021
44
Cutaneous metastasis from esophageal basaloid squamous cell carcinoma: A case report. 62
33596520 2021
45
Comparative Analysis of Clinicopathological Characteristics, Survival Features, and Protein Expression Between Basaloid and Squamous Cell Carcinoma of the Esophagus. 62
34345181 2021
46
Beyond Squamous Cell Carcinoma: Basaloid Squamous Cell Carcinoma of the Esophagus. 62
33585108 2021
47
Basaloid squamous cell carcinoma of gingiva: A rare case report. 62
34760071 2021
48
Diagnosis of NUT Carcinoma Despite False-Negative Next-Generation Sequencing Results: A Case Report and Literature Review. 62
34475768 2021
49
Dural and Multiple Brain Metastases From Basaloid Nasopharyngeal Carcinoma: Case Report and Literature Review. 62
34336659 2021
50
The Prognostic Impact of Preoperative Serum Apolipoprotein A-I in Patients with Esophageal Basaloid Squamous Cell Carcinoma. 62
34588815 2021

Variations for Basaloid Squamous Cell Carcinoma

Expression for Basaloid Squamous Cell Carcinoma

Search GEO for disease gene expression data for Basaloid Squamous Cell Carcinoma.

Pathways for Basaloid Squamous Cell Carcinoma

Pathways related to Basaloid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.24 SYP NKX2-1 NCAM1 ENO2
2 12.11 KRT8 KRT7 KRT5 KRT17
3
Show member pathways
12.09 KRT8 KRT7 KRT5 KRT17 KRT14
4
Show member pathways
11.84 KRT8 KRT7 KRT5 KRT17 KRT14
5 11.59 KIT CHGA CDKN2A
6 11.1 KRT5 KRT14 CDKN2A
7 10.81 TP53 KRT5 KRT17 KRT14

GO Terms for Basaloid Squamous Cell Carcinoma

Cellular components related to Basaloid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament cytoskeleton GO:0045111 9.63 KRT8 KRT7 KRT17
2 intermediate filament GO:0005882 9.61 KRT8 KRT7 KRT5 KRT17 KRT14
3 keratin filament GO:0045095 9.32 KRT8 KRT7 KRT5 KRT17 KRT14

Biological processes related to Basaloid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.56 KRT8 KRT7 KRT5 KRT17
2 mast cell chemotaxis GO:0002551 9.46 KIT CHGA
3 intermediate filament organization GO:0045109 9.32 KRT8 KRT7 KRT5 KRT17 KRT14

Molecular functions related to Basaloid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of skin epidermis GO:0030280 9.1 KRT8 KRT7 KRT5

Sources for Basaloid Squamous Cell Carcinoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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