MCID: BSL004
MIFTS: 36

Basilar Artery Occlusion

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Basilar Artery Occlusion

MalaCards integrated aliases for Basilar Artery Occlusion:

Name: Basilar Artery Occlusion 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:13446
ICD10 33 I65.1
ICD9CM 35 433.0
SNOMED-CT 68 78658006
UMLS 73 C0265098

Summaries for Basilar Artery Occlusion

MalaCards based summary : Basilar Artery Occlusion is related to acute myocardial infarction and vertebral artery occlusion. An important gene associated with Basilar Artery Occlusion is PLAT (Plasminogen Activator, Tissue Type), and among its related pathways/superpathways are Paradoxical activation of RAF signaling by kinase inactive BRAF and Myometrial Relaxation and Contraction Pathways. The drugs Glycerol and Mannitol have been mentioned in the context of this disorder. Affiliated tissues include brain and heart, and related phenotype is hematopoietic system.

Related Diseases for Basilar Artery Occlusion

Diseases related to Basilar Artery Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
# Related Disease Score Top Affiliating Genes
1 acute myocardial infarction 30.2 ITGA2B PLAT PLG
2 vertebral artery occlusion 29.9 FOSB PLG SLC25A16
3 ligneous conjunctivitis 10.2 PLAT PLG
4 intracranial embolism 10.2 PLAT PLG
5 inferior myocardial infarction 10.2 PLAT PLG
6 central retinal artery occlusion 10.2 PLAT PLG
7 brain stem infarction 10.2 APOBEC3G PLG
8 occlusion precerebral artery 10.2 PLAT PLG
9 acute cor pulmonale 10.2 PLAT PLG
10 acute pulmonary heart disease 10.2 PLAT PLG
11 acute anterolateral myocardial infarction 10.2 ITGA2B PLG
12 lateral myocardial infarction 10.2 ITGA2B PLG
13 intracranial vasospasm 10.2 PLAT TSPAN33
14 carotid artery thrombosis 10.2 ITGA2B PLAT
15 lemierre's syndrome 10.2 PLG SLC25A16
16 thrombosis 10.2
17 ischemia 10.2
18 pulmonary artery disease 10.1 PLAT PLG
19 intermediate coronary syndrome 10.1 ITGA2B PLAT PLG
20 arteries, anomalies of 10.1 ITGA2B PLAT PLG
21 intracranial thrombosis 10.1 ITGA2B PLG
22 carotid artery dissection 10.1 PLAT PLG
23 myocardial infarction 10.1
24 mutism 10.1
25 subdural empyema 10.0 FOSB TSPAN33
26 hepatic veno-occlusive disease 10.0 PLAT PLG
27 stroke, ischemic 10.0 PLAT PLG TSPAN33
28 muscular dystrophy, duchenne type 9.9
29 burns 9.9
30 hydrocephalus 9.9
31 cryptococcal meningitis 9.9
32 arteriovenous malformation 9.9
33 cortical blindness 9.9
34 locked-in syndrome 9.9
35 transient cerebral ischemia 9.9
36 syphilis 9.9
37 akinetic mutism 9.9
38 hydranencephaly 9.9
39 central nervous system vasculitis 9.9
40 vasculitis 9.9
41 meningitis 9.9
42 muscular dystrophy 9.9
43 headache 9.9

Graphical network of the top 20 diseases related to Basilar Artery Occlusion:



Diseases related to Basilar Artery Occlusion

Symptoms & Phenotypes for Basilar Artery Occlusion

MGI Mouse Phenotypes related to Basilar Artery Occlusion:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.23 ARRB1 ARRB2 GPR182 ITGA2B PANX1 PLAT

Drugs & Therapeutics for Basilar Artery Occlusion

Drugs for Basilar Artery Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glycerol Approved, Investigational Not Applicable 56-81-5 753
2
Mannitol Approved, Investigational Not Applicable 69-65-8 453 6251
3
Xylometazoline Approved, Investigational Not Applicable 526-36-3 5709
4 Tissue Plasminogen Activator Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Acute Basilar Artery Occlusion: Endovascular Interventions vs Standard Medical Treatment Completed NCT02441556 Not Applicable
2 Basilar Artery Occlusion Chinese Endovascular Trial Recruiting NCT02737189 Not Applicable Medical Treatment
3 Basilar Artery International Cooperation Study Recruiting NCT01717755 Not Applicable
4 Effect of Surgical Revascularization on Hemorrhagic Moyamoya Disease Recruiting NCT03627975 Not Applicable

Search NIH Clinical Center for Basilar Artery Occlusion

Genetic Tests for Basilar Artery Occlusion

Anatomical Context for Basilar Artery Occlusion

MalaCards organs/tissues related to Basilar Artery Occlusion:

41
Brain, Heart

Publications for Basilar Artery Occlusion

Articles related to Basilar Artery Occlusion:

(show top 50) (show all 308)
# Title Authors Year
1
Thrombolysis and adjunct anticoagulation in patients with acute basilar artery occlusion. ( 30134080 )
2019
2
Endovascular Treatment of Acute Basilar Artery Occlusion: Registro Endovascolare Lombardo Occlusione Basilar Artery (RELOBA) Study Group Experience. ( 29958848 )
2018
3
Basilar artery occlusion with "seizures" as a presenting symptom: three cases treated using mechanical thrombectomy. ( 29886293 )
2018
4
Acute Basilar Artery Occlusion: Does Recanalization Improve Clinical Outcome? A Critically Appraised Topic. ( 29494441 )
2018
5
The history of basilar artery occlusion: when art aids science. ( 29898084 )
2018
6
Outcome of endovascular treatment for acute basilar artery occlusion in the modern era: a single institution experience. ( 29651500 )
2018
7
Mechanical thrombectomy in basilar artery occlusion: influence of reperfusion on clinical outcome and impact of the first-line strategy (ADAPT vs stent retriever). ( 29327997 )
2018
8
The Basilar Artery on Computed Tomography Angiography Score for Acute Basilar Artery Occlusion Treated with Mechanical Thrombectomy. ( 29422378 )
2018
9
Predictors for Mortality after Mechanical Thrombectomy of Acute Basilar Artery Occlusion. ( 29393092 )
2018
10
Revascularization Techniques for Acute Basilar Artery Occlusion : Technical Considerations and Outcome in the Setting of Severe Posterior Circulation Steno-Occlusive Disease. ( 29651586 )
2018
11
Late recanalization of basilar artery occlusion in a previously healthy 17-month-old child. ( 29627789 )
2018
12
Correction to: Mechanical Thrombectomy in Basilar Artery Occlusion : Presence of Bilateral Posterior Communicating Arteries is a Predictor of Favorable Clinical Outcome. ( 29318351 )
2018
13
Endovascular Thrombectomy for Acute Basilar Artery Occlusion: A Multicenter Retrospective Observational Study. ( 29982231 )
2018
14
Early Diffusion-Weighted Imaging Brain Stem Score for Acute Basilar Artery Occlusion Treated with Mechanical Thrombectomy. ( 30072180 )
2018
15
Acute Basilar Artery Occlusion: Early Computed Tomography Finding Predicts Catastrophic Outcome. ( 30271072 )
2018
16
Endovascular therapy in acute basilar artery occlusion: A retrospective single-centre Australian analysis. ( 30407732 )
2018
17
Intravenous infusion of mesenchymal stem cells for protection against brainstem infarction in a persistent basilar artery occlusion model in the adult rat. ( 30485204 )
2018
18
Erratum. Mechanical thrombectomy in basilar artery occlusion: influence of reperfusion on clinical outcome and impact of the first-line strategy (ADAPT vs stent retriever). ( 30544327 )
2018
19
Concomitant carotid aplasia and basilar artery occlusion in a child with PHACES syndrome. ( 28814594 )
2017
20
Intra-arterial Treatment for Basilar Artery Occlusion. ( 27893872 )
2017
21
Treatment of acute basilar artery occlusion: Systematic review and meta-analysis. ( 28823413 )
2017
22
Clinical Outcomes of Patients with Acute Basilar Artery Occlusion in Brazil: An Observational Study. ( 28551292 )
2017
23
Efficacy and safety of direct aspiration first pass technique versus stent-retriever thrombectomy in acute basilar artery occlusion-a retrospective single center experience. ( 28251328 )
2017
24
Child Neurology: Childhood basilar artery occlusion and stroke. ( 28808172 )
2017
25
Mechanical Thrombectomy for Acute Basilar Artery Occlusion in Early Therapeutic Time Window. ( 28848166 )
2017
26
Multimodal Therapy for Non-Superacute Vertebral Basilar Artery Occlusion. ( 29118803 )
2017
27
Acute basilar artery occlusion: Endovascular Interventions versus Standard Medical Treatment (BEST) Trial-Design and protocol for a randomized, controlled, multicenter study. ( 28361616 )
2017
28
Acute superior mesenteric artery occlusion complicated by basilar artery occlusion. ( 28828111 )
2017
29
Hybrid Retrograde-Antegrade Recanalization of Acute Basilar Artery Occlusion. ( 29118804 )
2017
30
Acute Basilar Artery Occlusion: Differences in Characteristics and Outcomes after Endovascular Therapy between Patients with and without Underlying Severe Atherosclerotic Stenosis. ( 28546252 )
2017
31
Mechanical Thrombectomy in Basilar Artery Occlusion : Presence of Bilateral Posterior Communicating Arteries is aA Predictor of Favorable Clinical Outcome. ( 29260256 )
2017
32
Late recanalization of basilar artery occlusion in a previously healthy 17-month-old child. ( 29030498 )
2017
33
Effectiveness and Safety of Mechanical Thrombectomy with Stent Retrievers in Basilar Artery Occlusion: Comparison with Anterior Circulation Occlusions. ( 29142622 )
2017
34
ADC quantification in basilar artery occlusion as an indicator of clinical outcome after endovascular treatment. ( 28699370 )
2017
35
The Basilar Artery on Computed Tomography Angiography Prognostic Score for Basilar Artery Occlusion. ( 28228577 )
2017
36
The efficiency analysis of thrombolytic rt-PA combined with intravascular interventional therapy in patients with acute basilar artery occlusion. ( 28123346 )
2017
37
Dominant vertebral artery status and functional outcome after endovascular therapy of symptomatic basilar artery occlusion. ( 28131432 )
2017
38
Intra-arterial Treatment for Basilar Artery Occlusion-Reply. ( 27893877 )
2017
39
Neuroimaging Predictors of Clinical Outcome in Acute Basilar Artery Occlusion. ( 28674517 )
2017
40
Cerebral blood volume lesion extent predicts functional outcome in patients with vertebral and basilar artery occlusion. ( 29160168 )
2017
41
Collateral flow predicts outcome after basilar artery occlusion: The posterior circulation collateral score. ( 27016515 )
2016
42
Endovascular mechanical thrombectomy in basilar artery occlusion: variables affecting recanalization and outcome. ( 26872664 )
2016
43
Where did the clot go? An unusual complication of mechanical thrombectomy caused by malignancy related subclavian steal phenomenon in a patient with acute basilar artery occlusion. ( 27797875 )
2016
44
Mechanical thrombectomy in acute basilar artery occlusion: A safety and efficacy single centre study. ( 26908588 )
2016
45
Revascularization of acute basilar artery occlusion using theA Tigertriever adjustable clot retriever. ( 27511204 )
2016
46
A leap forward in the endovascular management of acute basilar artery occlusion since the appearance of stent retrievers: a single-center comparative study. ( 27257830 )
2016
47
Thrombectomy using a stent retriever with artificially induced vertebral artery vasospasm in a patient with acute basilar artery occlusion: a case report. ( 26678752 )
2016
48
Basilar artery occlusion in a child treated successfully with mechanical thrombectomy using ADAPT. ( 27068722 )
2016
49
A Comparison between Mechanical Thrombectomy and Intra-arterial Fibrinolysis in Acute Basilar Artery Occlusion: Single Center Experiences. ( 27283281 )
2016
50
Safety and Outcome of Intra-Arterial Treatment for Basilar Artery Occlusion. ( 27532477 )
2016

Variations for Basilar Artery Occlusion

Expression for Basilar Artery Occlusion

Search GEO for disease gene expression data for Basilar Artery Occlusion.

Pathways for Basilar Artery Occlusion

GO Terms for Basilar Artery Occlusion

Cellular components related to Basilar Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.32 ARRB1 ARRB2 GPR182 ITGA2B OXTR PANX1

Biological processes related to Basilar Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to progesterone GO:0032570 9.37 FOSB OXTR
2 negative regulation of interleukin-6 production GO:0032715 9.32 ARRB1 ARRB2
3 positive regulation of receptor internalization GO:0002092 9.26 ARRB1 ARRB2
4 fibrinolysis GO:0042730 9.16 PLAT PLG
5 G protein-coupled receptor internalization GO:0002031 8.96 ARRB1 ARRB2
6 follicle-stimulating hormone signaling pathway GO:0042699 8.62 ARRB1 ARRB2

Molecular functions related to Basilar Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.72 ARRB1 ARRB2 PANX1 PLAT PLG
2 enzyme binding GO:0019899 9.71 ARRB1 ARRB2 PLG TSPAN33
3 phosphoprotein binding GO:0051219 9.43 ARRB1 PLAT
4 arrestin family protein binding GO:1990763 9.37 ARRB1 ARRB2
5 alpha-1B adrenergic receptor binding GO:0031692 9.26 ARRB1 ARRB2
6 angiotensin receptor binding GO:0031701 9.16 ARRB1 ARRB2
7 alpha-1A adrenergic receptor binding GO:0031691 8.96 ARRB1 ARRB2
8 follicle-stimulating hormone receptor binding GO:0031762 8.62 ARRB1 ARRB2

Sources for Basilar Artery Occlusion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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