MCID: BSL004
MIFTS: 38

Basilar Artery Occlusion

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Basilar Artery Occlusion

MalaCards integrated aliases for Basilar Artery Occlusion:

Name: Basilar Artery Occlusion 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:13446
ICD9CM 36 433.0
SNOMED-CT 69 78658006
ICD10 34 I65.1
UMLS 74 C0265098

Summaries for Basilar Artery Occlusion

MalaCards based summary : Basilar Artery Occlusion is related to acute myocardial infarction and vertebral artery occlusion. An important gene associated with Basilar Artery Occlusion is PLAT (Plasminogen Activator, Tissue Type), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Myometrial Relaxation and Contraction Pathways. The drugs Mannitol and Xylometazoline have been mentioned in the context of this disorder. Affiliated tissues include brain, pons and heart, and related phenotypes are hematopoietic system and nervous system

Related Diseases for Basilar Artery Occlusion

Diseases related to Basilar Artery Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 acute myocardial infarction 30.4 ITGA2B PLAT PLG
2 vertebral artery occlusion 29.8 FOSB PLG SLC25A16
3 ligneous conjunctivitis 10.4 PLAT PLG
4 inferior myocardial infarction 10.4 PLAT PLG
5 brain stem infarction 10.4 APOBEC3G PLG
6 central retinal artery occlusion 10.4 PLAT PLG
7 acute anterolateral myocardial infarction 10.4 ITGA2B PLG
8 lateral myocardial infarction 10.4 ITGA2B PLG
9 cerebral falx meningioma 10.4 F2 PLG
10 leech infestation 10.3 F2 PLG
11 intracranial vasospasm 10.3 PLAT TSPAN33
12 intestinal impaction 10.3 F2 PLG
13 alpha-2-plasmin inhibitor deficiency 10.3 F2 PLG
14 giant hemangioma 10.3 F2 PLG
15 occlusion precerebral artery 10.3 PLAT PLG
16 carotid artery thrombosis 10.3 ITGA2B PLAT
17 blue toe syndrome 10.3 F2 PLG
18 femoral neuropathy 10.3 F2 PLG
19 acute cor pulmonale 10.3 PLAT PLG
20 intermediate coronary syndrome 10.3 ITGA2B PLAT PLG
21 anterior cranial fossa meningioma 10.3 F2 PLG
22 korean hemorrhagic fever 10.3 F2 PLG
23 arteries, anomalies of 10.3 ITGA2B PLAT PLG
24 marantic endocarditis 10.3 F2 PLAT
25 intracranial embolism 10.3 F2 PLAT PLG
26 pulmonary artery disease 10.2 F2 PLAT PLG
27 vein disease 10.2 F2 PLAT PLG
28 thrombophilia due to activated protein c resistance 10.2 F2 PLAT PLG
29 livedoid vasculitis 10.2 F2 PLG
30 coronary artery anomaly 10.2 F2 PLAT PLG
31 blood coagulation disease 10.2 F2 ITGA2B PLG
32 retinal vascular occlusion 10.2 F2 PLG
33 hemorrhagic disease 10.2 F2 ITGA2B PLAT
34 thrombosis 10.2
35 ischemia 10.2
36 thrombophlebitis 10.2 F2 PLAT
37 acute pulmonary heart disease 10.1 PLAT PLG
38 anterior spinal artery syndrome 10.1 F2 PLG
39 cerebrovascular disease 10.1 F2 ITGA2B PLAT
40 carotid artery dissection 10.1 DFFA PLAT PLG
41 myocardial infarction 10.1
42 mutism 10.1
43 stroke, ischemic 10.0 F2 PLAT PLG TSPAN33
44 immune system disease 10.0 ARRB1 ARRB2 ITGA2B
45 ocular motor apraxia 9.9
46 muscular dystrophy, duchenne type 9.9
47 human immunodeficiency virus type 1 9.9
48 burns 9.9
49 hydrocephalus 9.9
50 cryptococcal meningitis 9.9

Graphical network of the top 20 diseases related to Basilar Artery Occlusion:



Diseases related to Basilar Artery Occlusion

Symptoms & Phenotypes for Basilar Artery Occlusion

MGI Mouse Phenotypes related to Basilar Artery Occlusion:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.61 ARRB1 ARRB2 F2 GPR182 ITGA2B PANX1
2 nervous system MP:0003631 9.28 ARRB1 ARRB2 DFFA F2 FOSB OXTR

Drugs & Therapeutics for Basilar Artery Occlusion

Drugs for Basilar Artery Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mannitol Approved, Investigational Not Applicable 69-65-8 6251 453
2
Xylometazoline Approved, Investigational Not Applicable 526-36-3 5709
3
Glycerol Approved, Investigational Not Applicable 56-81-5 753
4 Tissue Plasminogen Activator Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Acute Basilar Artery Occlusion: Endovascular Interventions vs Standard Medical Treatment Completed NCT02441556 Not Applicable
2 Basilar Artery Occlusion Chinese Endovascular Trial Recruiting NCT02737189 Not Applicable Medical Treatment
3 Basilar Artery International Cooperation Study Recruiting NCT01717755 Not Applicable
4 Effect of Surgical Revascularization on Hemorrhagic Moyamoya Disease Recruiting NCT03627975 Not Applicable

Search NIH Clinical Center for Basilar Artery Occlusion

Genetic Tests for Basilar Artery Occlusion

Anatomical Context for Basilar Artery Occlusion

MalaCards organs/tissues related to Basilar Artery Occlusion:

42
Brain, Pons, Heart

Publications for Basilar Artery Occlusion

Articles related to Basilar Artery Occlusion:

(show top 50) (show all 322)
# Title Authors Year
1
DWI-pc-ASPECT score in basilar artery occlusion: is 6 points or less always indicative of a bad outcome? ( 30803336 )
2019
2
Basilar artery occlusion successfully treated with delayed intravascular intervention and mild hypothermia. ( 30855353 )
2019
3
Mechanical Thrombectomy in Subtypes of Basilar Artery Occlusion: Relationship to Recanalization Rate and Clinical Outcome. ( 30912720 )
2019
4
Diving into a Shallow Pool: Endovascular Treatment for Basilar Artery Occlusion. ( 30917294 )
2019
5
Endovascular treatment of acute basilar artery occlusion: Tama-REgistry of Acute Thrombectomy (TREAT) study. ( 31005761 )
2019
6
Therapy for acute basilar artery occlusion: a systematic review and meta-analysis. ( 31016013 )
2019
7
Rapid Successful Reperfusion of Basilar Artery Occlusion Strokes With Pretreatment Diffusion-Weighted Imaging Posterior-Circulation ASPECTS <8 Is Associated With Good Outcome. ( 31070075 )
2019
8
Delayed Revascularization in Patients With Basilar Artery Occlusion. ( 31092160 )
2019
9
Response to Late-Window Endovascular Revascularization Is Associated With Collateral Status in Basilar Artery Occlusion. ( 31092168 )
2019
10
Firstline a direct aspiration first pass technique versus firstline stent retriever for acute basilar artery occlusion: a systematic review and meta-analysis. ( 30692214 )
2019
11
Value of Posterior circulation ASPECTS and Pons-Midbrain Index on non-contrast CT and CT Angiography Source Images in patients with basilar artery occlusion recanalized after mechanical thrombectomy. ( 30616862 )
2019
12
Nuances of transradial approach for mechanical thombectomy in acute basilar artery occlusion. ( 30611178 )
2019
13
Endovascular management of basilar artery occlusion secondary to fusiform aneurysm with intraluminal thrombus. ( 30611176 )
2019
14
Endovascular therapy in acute basilar artery occlusion: A retrospective single-centre Australian analysis. ( 30407732 )
2019
15
Thrombolysis and adjunct anticoagulation in patients with acute basilar artery occlusion. ( 30134080 )
2019
16
Correction to: Mechanical Thrombectomy in Basilar Artery Occlusion : Presence of Bilateral Posterior Communicating Arteries is a Predictor of Favorable Clinical Outcome. ( 29318351 )
2019
17
Mechanical Thrombectomy in Basilar Artery Occlusion : Presence of Bilateral Posterior Communicating Arteries is a Predictor of Favorable Clinical Outcome. ( 29260256 )
2019
18
Recovery of injured corticospinal tracts after late recanalisation of basilar artery occlusion. ( 30637132 )
2018
19
Erratum. Mechanical thrombectomy in basilar artery occlusion: influence of reperfusion on clinical outcome and impact of the first-line strategy (ADAPT vs stent retriever). ( 30544327 )
2018
20
Intravenous infusion of mesenchymal stem cells for protection against brainstem infarction in a persistent basilar artery occlusion model in the adult rat. ( 30485204 )
2018
21
Acute Basilar Artery Occlusion: Early Computed Tomography Finding Predicts Catastrophic Outcome. ( 30271072 )
2018
22
Early Diffusion-Weighted Imaging Brain Stem Score for Acute Basilar Artery Occlusion Treated with Mechanical Thrombectomy. ( 30072180 )
2018
23
Endovascular Thrombectomy for Acute Basilar Artery Occlusion: A Multicenter Retrospective Observational Study. ( 29982231 )
2018
24
Endovascular Treatment of Acute Basilar Artery Occlusion: Registro Endovascolare Lombardo Occlusione Basilar Artery (RELOBA) Study Group Experience. ( 29958848 )
2018
25
The history of basilar artery occlusion: when art aids science. ( 29898084 )
2018
26
Basilar Artery Occlusion with "Seizures" as a Presenting Symptom: Three Cases Treated Using Mechanical Thrombectomy. ( 29886293 )
2018
27
Revascularization Techniques for Acute Basilar Artery Occlusion : Technical Considerations and Outcome in the Setting of Severe Posterior Circulation Steno-Occlusive Disease. ( 29651586 )
2018
28
Outcome of endovascular treatment for acute basilar artery occlusion in the modern era: a single institution experience. ( 29651500 )
2018
29
Late recanalization of basilar artery occlusion in a previously healthy 17-month-old child. ( 29627789 )
2018
30
Acute Basilar Artery Occlusion: Does Recanalization Improve Clinical Outcome? A Critically Appraised Topic. ( 29494441 )
2018
31
The Basilar Artery on Computed Tomography Angiography Score for Acute Basilar Artery Occlusion Treated with Mechanical Thrombectomy. ( 29422378 )
2018
32
Predictors for Mortality after Mechanical Thrombectomy of Acute Basilar Artery Occlusion. ( 29393092 )
2018
33
Mechanical thrombectomy in basilar artery occlusion: influence of reperfusion on clinical outcome and impact of the first-line strategy (ADAPT vs stent retriever). ( 29327997 )
2018
34
The efficiency analysis of thrombolytic rt-PA combined with intravascular interventional therapy in patients with acute basilar artery occlusion. ( 28123346 )
2017
35
Dominant vertebral artery status and functional outcome after endovascular therapy of symptomatic basilar artery occlusion. ( 28131432 )
2017
36
The Basilar Artery on Computed Tomography Angiography Prognostic Score for Basilar Artery Occlusion. ( 28228577 )
2017
37
Efficacy and safety of direct aspiration first pass technique versus stent-retriever thrombectomy in acute basilar artery occlusion-a retrospective single center experience. ( 28251328 )
2017
38
Intra-arterial Treatment for Basilar Artery Occlusion-Reply. ( 27893877 )
2017
39
Intra-arterial Treatment for Basilar Artery Occlusion. ( 27893872 )
2017
40
Where did the clot go? An unusual complication of mechanical thrombectomy caused by malignancy related subclavian steal phenomenon in a patient with acute basilar artery occlusion. ( 27799374 )
2017
41
Successful recanalization in acute basilar artery occlusion treated with endovascular therapy is independent of thrombus length. ( 27789788 )
2017
42
Editorial: Cocaine and Acute Basilar Artery Occlusion: What we Know to Date? ( 27633287 )
2017
43
Revascularization of acute basilar artery occlusion using the Tigertriever adjustable clot retriever. ( 27511204 )
2017
44
A leap forward in the endovascular management of acute basilar artery occlusion since the appearance of stent retrievers: a single-center comparative study. ( 27257830 )
2017
45
Basilar artery occlusion in a child treated successfully with mechanical thrombectomy using ADAPT. ( 27075484 )
2017
46
Cerebral blood volume lesion extent predicts functional outcome in patients with vertebral and basilar artery occlusion. ( 29160168 )
2017
47
Effectiveness and Safety of Mechanical Thrombectomy with Stent Retrievers in Basilar Artery Occlusion: Comparison with Anterior Circulation Occlusions. ( 29142622 )
2017
48
Hybrid Retrograde-Antegrade Recanalization of Acute Basilar Artery Occlusion. ( 29118804 )
2017
49
Multimodal Therapy for Non-Superacute Vertebral Basilar Artery Occlusion. ( 29118803 )
2017
50
Late recanalization of basilar artery occlusion in a previously healthy 17-month-old child. ( 29030498 )
2017

Variations for Basilar Artery Occlusion

Expression for Basilar Artery Occlusion

Search GEO for disease gene expression data for Basilar Artery Occlusion.

Pathways for Basilar Artery Occlusion

Pathways related to Basilar Artery Occlusion according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.88 ARRB1 ARRB2 F2 ITGA2B PLAT PLG
2
Show member pathways
11.95 ARRB1 ARRB2 GPR182 OXTR
3
Show member pathways
11.87 ARRB1 ARRB2 F2
4
Show member pathways
11.85 F2 PLAT PLG
5 11.75 F2 PLAT PLG
6
Show member pathways
11.71 ARRB1 ARRB2 ITGA2B
7
Show member pathways
11.53 F2 PLAT PLG
8 10.97 ARRB2 SLC12A3
9 10.82 PLAT PLG
10 10.77 ARRB1 ARRB2 FOSB
11 10.69 F2 PLG
12 10.07 PLAT PLG

GO Terms for Basilar Artery Occlusion

Cellular components related to Basilar Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.4 ARRB1 ARRB2 DFFA F2 GPR182 ITGA2B
2 blood microparticle GO:0072562 9.13 F2 ITGA2B PLG

Biological processes related to Basilar Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.56 F2 GPR182 OXTR TSPAN33
2 platelet activation GO:0030168 9.54 ARRB1 ARRB2 F2
3 negative regulation of interleukin-6 production GO:0032715 9.48 ARRB1 ARRB2
4 negative regulation of proteolysis GO:0045861 9.46 F2 PLAT
5 positive regulation of collagen biosynthetic process GO:0032967 9.43 ARRB2 F2
6 positive regulation of receptor internalization GO:0002092 9.4 ARRB1 ARRB2
7 G protein-coupled receptor internalization GO:0002031 9.32 ARRB1 ARRB2
8 negative regulation of fibrinolysis GO:0051918 9.16 F2 PLG
9 follicle-stimulating hormone signaling pathway GO:0042699 8.96 ARRB1 ARRB2
10 fibrinolysis GO:0042730 8.8 F2 PLAT PLG

Molecular functions related to Basilar Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.71 ARRB1 ARRB2 PLG TSPAN33
2 serine-type peptidase activity GO:0008236 9.61 F2 PLAT PLG
3 arrestin family protein binding GO:1990763 9.37 ARRB1 ARRB2
4 alpha-1B adrenergic receptor binding GO:0031692 9.32 ARRB1 ARRB2
5 angiotensin receptor binding GO:0031701 9.26 ARRB1 ARRB2
6 alpha-1A adrenergic receptor binding GO:0031691 9.16 ARRB1 ARRB2
7 signaling receptor binding GO:0005102 9.1 ARRB1 ARRB2 F2 PANX1 PLAT PLG
8 follicle-stimulating hormone receptor binding GO:0031762 8.96 ARRB1 ARRB2

Sources for Basilar Artery Occlusion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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