MCID: BSP001
MIFTS: 28

Basophil Adenoma

Categories: Blood diseases, Cancer diseases, Endocrine diseases

Aliases & Classifications for Basophil Adenoma

MalaCards integrated aliases for Basophil Adenoma:

Name: Basophil Adenoma 12 15 17
Adenoma, Basophil 43 71
Pituitary Gland Basophilic Adenoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4542
MeSH 43 D000237
NCIt 49 C2856
SNOMED-CT 67 9436005
UMLS 71 C0001431

Summaries for Basophil Adenoma

MalaCards based summary : Basophil Adenoma, also known as adenoma, basophil, is related to acth-secreting pituitary adenoma and acromegaly. An important gene associated with Basophil Adenoma is POMC (Proopiomelanocortin), and among its related pathways/superpathways are Aldosterone synthesis and secretion and G alpha (s) signalling events. The drugs Dexamethasone acetate and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include pituitary and t cells, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Basophil Adenoma

Diseases related to Basophil Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 acth-secreting pituitary adenoma 29.5 PRKAR1A POMC
2 acromegaly 29.1 PRKAR1A POMC
3 adrenal carcinoma 29.0 PRKAR1A POMC PDE11A
4 conn's syndrome 29.0 PRKAR1A POMC PDE11A
5 mixed eosinophil-basophil adenoma 12.5
6 adenoma 10.5
7 myxedema 10.0
8 pituitary adenoma 4, acth-secreting 9.9
9 goiter 9.9
10 pituitary tumors 9.9
11 froelich syndrome 9.9 MS4A6E MS4A4A
12 alzheimer disease 4 9.9 MS4A6E MS4A4A
13 hormone producing pituitary cancer 9.8 PRKAR1A POMC
14 hyperpituitarism 9.8 PRKAR1A POMC
15 pituitary adenoma 9.8 PRKAR1A POMC
16 growth hormone secreting pituitary adenoma 9.8 PRKAR1A POMC
17 lentigines 9.8 PRKAR1A POMC
18 functioning pituitary adenoma 9.8 PRKAR1A POMC
19 osseous heteroplasia, progressive 9.7 PRKAR1A POMC
20 adrenal cortical adenoma 9.7 PRKAR1A POMC
21 thyroid carcinoma, familial medullary 9.7 PRKAR1A POMC
22 adrenal adenoma 9.7 PRKAR1A POMC
23 pituitary gland disease 9.7 PRKAR1A POMC
24 paraganglioma and gastric stromal sarcoma 9.7 PRKAR1A PDE11A
25 endocrine organ benign neoplasm 9.7 PRKAR1A POMC
26 primary hyperparathyroidism 9.6 PRKAR1A POMC
27 pituitary adenoma, prolactin-secreting 9.6 PRKAR1A POMC
28 multiple endocrine neoplasia, type i 9.6 PRKAR1A POMC
29 sex cord-gonadal stromal tumor 9.4 PRKAR1A POMC PDE11A
30 adrenal cortical carcinoma 9.4 PRKAR1A POMC PDE11A
31 adrenal gland disease 9.4 PRKAR1A POMC PDE11A
32 breast ductal adenoma 9.4 PRKAR1A PDE8B PDE11A
33 breast adenoma 9.4 PRKAR1A PDE8B PDE11A
34 acth-independent cushing syndrome 9.4 PRKAR1A PDE8B PDE11A
35 mccune-albright syndrome 9.4 PRKAR1A PDE8B PDE11A
36 melanotic neurilemmoma 9.1 PRKAR1A POMC PDE8B PDE11A
37 acth-independent macronodular adrenal hyperplasia 9.1 PRKAR1A POMC PDE8B PDE11A
38 adrenal cortex disease 9.1 PRKAR1A POMC PDE8B PDE11A
39 carney complex variant 9.1 PRKAR1A POMC PDE8B PDE11A
40 primary pigmented nodular adrenocortical disease 9.1 PRKAR1A POMC PDE8B PDE11A
41 osteoporosis 8.9 PRKAR1A PDE8B PDE11A

Graphical network of the top 20 diseases related to Basophil Adenoma:



Diseases related to Basophil Adenoma

Symptoms & Phenotypes for Basophil Adenoma

GenomeRNAi Phenotypes related to Basophil Adenoma according to GeneCards Suite gene sharing:

26 (show all 30)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-105 9.91 MS4A4A PRKAR1A
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-106 9.91 MS4A4A
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-124 9.91 MS4A6E
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-136 9.91 MS4A4A
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-16 9.91 PRKAR1A
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-164 9.91 PRKAR1A
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-189 9.91 PRKAR1A
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 9.91 MS4A4A
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-212 9.91 MS4A4A
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-32 9.91 MS4A6E
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-39 9.91 PRKAR1A
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.91 PRKAR1A
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-5 9.91 MS4A4A
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-50 9.91 PRKAR1A
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.91 PRKAR1A
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-70 9.91 MS4A6E
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.91 PRKAR1A
18 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.47 POMC
19 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.47 MS4A6E
20 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.47 MS4A6E
21 Increased shRNA abundance (Z-score > 2) GR00366-A-139 9.47 MS4A6E
22 Increased shRNA abundance (Z-score > 2) GR00366-A-170 9.47 MS4A6E
23 Increased shRNA abundance (Z-score > 2) GR00366-A-18 9.47 MS4A6E
24 Increased shRNA abundance (Z-score > 2) GR00366-A-187 9.47 PDE11A
25 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.47 MS4A6E
26 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.47 PDE11A POMC
27 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.47 MS4A6E
28 Increased shRNA abundance (Z-score > 2) GR00366-A-72 9.47 MS4A6E
29 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.47 PDE11A
30 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.47 POMC

Drugs & Therapeutics for Basophil Adenoma

Drugs for Basophil Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1 1177-87-3
2
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
3 Gastrointestinal Agents Phase 1
4 Hormones Phase 1
5 Antineoplastic Agents, Hormonal Phase 1
6 Antiemetics Phase 1
7 Hormone Antagonists Phase 1
8 glucocorticoids Phase 1
9 BB 1101 Phase 1
10 Anti-Inflammatory Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A PHASE 1/2 STUDY OF RO4929097, AN ORAL SMALL MOLECULE INHIBITOR OF GAMMA-SECRETASE, IN CHILDREN WITH RELAPSED/REFRACTORY SOLID OR CNS TUMORS, LYMPHOMA, OR T-CELL LEUKEMIA Terminated NCT01088763 Phase 1 gamma-secretase/Notch signalling pathway inhibitor RO4929097;dexamethasone

Search NIH Clinical Center for Basophil Adenoma

Cochrane evidence based reviews: adenoma, basophil

Genetic Tests for Basophil Adenoma

Anatomical Context for Basophil Adenoma

MalaCards organs/tissues related to Basophil Adenoma:

40
Pituitary, T Cells

Publications for Basophil Adenoma

Articles related to Basophil Adenoma:

(show all 17)
# Title Authors PMID Year
1
Transnasal stereotactic surgery of pituitary adenomas concomitant with acromegaly. 61
8916351 1995
2
[Genetic aspects of renal tumors in adults]. 61
1304117 1992
3
Cushing's disease in a young woman with anorexia nervosa: pathophysiological implications. 61
3026602 1986
4
Cyclical Cushing's disease: two distinct rhythms in a patient with a basophil adenoma. 61
2981244 1985
5
Mania in Cushing's syndrome: case report. 61
6317660 1983
6
Cyproheptadine-induced remission of Cushing's disease due to pituitary basophil adenoma. 61
6295736 1982
7
Electroconvulsive therapy following pituitary surgery. 61
41885 1979
8
Pregnancy and Nelson's syndrome. Two case reports. 61
698156 1978
9
Cushing's syndrome, nodular adrenal hyperplasia and virilizing carcinoma. 61
209918 1978
10
[Pituitary adenoma with alpha, 17-39 ACTH and beta, MSH cells, without hypercorticism (author's transl)]. 61
207217 1978
11
Treatment of Nelson's syndrome by pituitary implantation of yttrium-90 or gold-198. 61
182313 1976
12
[Mixed adenoma (basophil & eosinophil) of the pituitary, with bitemporal hemianopsia, Cushing syndrome and acromegaly]. 61
13579569 1958
13
[Cushing's disease with basophil adenoma]. 61
12994178 1952
14
[Basophil adenoma with slow evolution and virilism]. 61
12980573 1952
15
Pars intermedia basophil adenoma of the hypophysis. 61
19970391 1938
16
BASOPHIL ADENOMA OF THE PITUITARY GLAND WITH RENAL CHANGES. 61
20778876 1935
17
Cardiovascular Renal Changes Associated with Basophil Adenoma of the Anterior Lobe of the Pituitary (Cushing's Syndrome). 61
19970135 1934

Variations for Basophil Adenoma

Expression for Basophil Adenoma

Search GEO for disease gene expression data for Basophil Adenoma.

Pathways for Basophil Adenoma

Pathways related to Basophil Adenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.1 POMC PDE8B PDE11A
2 10.96 POMC PDE8B PDE11A
3 10.57 PRKAR1A POMC

GO Terms for Basophil Adenoma

Molecular functions related to Basophil Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphoric diester hydrolase activity GO:0008081 9.16 PDE8B PDE11A
2 3',5'-cyclic-nucleotide phosphodiesterase activity GO:0004114 8.96 PDE8B PDE11A
3 3',5'-cyclic-GMP phosphodiesterase activity GO:0047555 8.62 PRKAR1A PDE11A

Sources for Basophil Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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