MCID: BSP001
MIFTS: 29

Basophil Adenoma

Categories: Blood diseases, Cancer diseases, Endocrine diseases
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Aliases & Classifications for Basophil Adenoma

MalaCards integrated aliases for Basophil Adenoma:

Name: Basophil Adenoma 11 14 16
Adenoma, Basophil 43 71
Pituitary Gland Basophilic Adenoma 11

Classifications:



External Ids:

Disease Ontology 11 DOID:4542
MeSH 43 D000237
NCIt 49 C2856
SNOMED-CT 68 9436005
UMLS 71 C0001431

Summaries for Basophil Adenoma

MalaCards based summary: Basophil Adenoma, also known as adenoma, basophil, is related to adenoma and acromegaly. An important gene associated with Basophil Adenoma is POMC (Proopiomelanocortin), and among its related pathways/superpathways are Signal Transduction and GPCR downstream signalling. The drugs Dexamethasone acetate and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include pituitary, and related phenotype is Increased shRNA abundance (Z-score > 2).

Related Diseases for Basophil Adenoma

Diseases related to Basophil Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 adenoma 30.0 PRKAR1A POMC GNAS
2 acromegaly 29.4 POMC GNAS
3 pituitary adenoma 29.3 PRKAR1A POMC GNAS
4 conn's syndrome 29.0 PRKAR1A POMC PDE8B PDE11A GNAS
5 mixed eosinophil-basophil adenoma 11.4
6 pituitary-dependent cushing's disease 10.2
7 acth-independent macronodular adrenal hyperplasia 1 10.0 POMC GNAS
8 dowling-degos disease 1 10.0 POMC GNAS
9 diencephalic neoplasm 10.0 PDE8B PDE11A
10 hypothalamic neoplasm 10.0 PDE8B PDE11A
11 precocious puberty, male-limited 10.0 POMC GNAS
12 hyperprolactinemia 9.9 POMC GNAS
13 pituitary tumors 9.9
14 thyroid gland disease 9.9 POMC GNAS
15 pseudohypoparathyroidism 9.8 PRKAR1A GNAS
16 hypoparathyroidism 9.8 PRKAR1A GNAS
17 acth-secreting pituitary adenoma 9.8 PRKAR1A POMC
18 breast ductal adenoma 9.8 PRKAR1A PDE11A
19 breast adenoma 9.8 PRKAR1A PDE11A
20 hypertension and brachydactyly syndrome 9.8 PRKAR1A GNAS
21 pseudopseudohypoparathyroidism 9.8 PRKAR1A GNAS
22 multiple endocrine neoplasia, type iv 9.8 PRKAR1A GNAS
23 adrenal cortical adenoma 9.8 PRKAR1A POMC
24 dicer1 syndrome 9.8 PRKAR1A GNAS
25 hypothyroidism, congenital, nongoitrous, 1 9.8 PRKAR1A GNAS
26 hyperthyroidism 9.8 POMC GNAS
27 acrodysostosis 9.8 PRKAR1A GNAS
28 lissencephaly, x-linked, 2 9.8 PRKAR1A GNAS
29 hypothyroidism 9.8 POMC PDE8B GNAS
30 osseous heteroplasia, progressive 9.8 PRKAR1A GNAS
31 pseudohypoparathyroidism, type ib 9.8 PRKAR1A GNAS
32 hypocalcemia, autosomal dominant 1 9.7 PRKAR1A GNAS
33 parathyroid adenoma 9.7 PRKAR1A GNAS
34 endocrine organ benign neoplasm 9.7 PRKAR1A POMC
35 peutz-jeghers syndrome 9.7 PRKAR1A GNAS
36 hormone producing pituitary cancer 9.6 PRKAR1A POMC GNAS
37 pituitary cancer 9.6 PRKAR1A POMC GNAS
38 hyperpituitarism 9.6 PRKAR1A POMC GNAS
39 pseudohypoparathyroidism, type ia 9.6 PRKAR1A POMC GNAS
40 functioning pituitary adenoma 9.6 PRKAR1A POMC GNAS
41 growth hormone secreting pituitary adenoma 9.6 PRKAR1A POMC GNAS
42 adrenal adenoma 9.6 PRKAR1A POMC GNAS
43 pituitary gland disease 9.6 PRKAR1A POMC GNAS
44 multiple endocrine neoplasia 9.6 PRKAR1A POMC GNAS
45 multiple endocrine neoplasia, type i 9.6 PRKAR1A POMC GNAS
46 prolactinoma 9.6 PRKAR1A POMC GNAS
47 beckwith-wiedemann syndrome 9.5 PRKAR1A PDE11A GNAS
48 melanotic neurilemmoma 9.4 PRKAR1A POMC PDE8B PDE11A
49 adrenal cortex disease 9.4 PRKAR1A POMC PDE8B PDE11A
50 adrenal carcinoma 9.4 PRKAR1A POMC PDE8B PDE11A

Graphical network of the top 20 diseases related to Basophil Adenoma:



Diseases related to Basophil Adenoma

Symptoms & Phenotypes for Basophil Adenoma

GenomeRNAi Phenotypes related to Basophil Adenoma according to GeneCards Suite gene sharing:

25 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.47 POMC
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.47 MS4A6E
3 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.47 MS4A6E
4 Increased shRNA abundance (Z-score > 2) GR00366-A-139 9.47 MS4A6E
5 Increased shRNA abundance (Z-score > 2) GR00366-A-170 9.47 MS4A6E
6 Increased shRNA abundance (Z-score > 2) GR00366-A-18 9.47 MS4A6E
7 Increased shRNA abundance (Z-score > 2) GR00366-A-187 9.47 PDE11A
8 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.47 MS4A6E
9 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.47 PDE11A POMC
10 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.47 MS4A6E
11 Increased shRNA abundance (Z-score > 2) GR00366-A-72 9.47 MS4A6E
12 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.47 PDE11A
13 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.47 POMC

Drugs & Therapeutics for Basophil Adenoma

Drugs for Basophil Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1 1177-87-3 3680
2
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 3003 5743
3 Antineoplastic Agents, Hormonal Phase 1
4 R04929097 Phase 1
5 Hormones Phase 1
6 Hormone Antagonists Phase 1
7 Antiemetics Phase 1
8 glucocorticoids Phase 1
9 BB 1101 Phase 1
10 Anti-Inflammatory Agents Phase 1
11 Gastrointestinal Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A PHASE 1/2 STUDY OF RO4929097, AN ORAL SMALL MOLECULE INHIBITOR OF GAMMA-SECRETASE, IN CHILDREN WITH RELAPSED/REFRACTORY SOLID OR CNS TUMORS, LYMPHOMA, OR T-CELL LEUKEMIA Terminated NCT01088763 Phase 1 gamma-secretase/Notch signalling pathway inhibitor RO4929097;dexamethasone

Search NIH Clinical Center for Basophil Adenoma

Cochrane evidence based reviews: adenoma, basophil

Genetic Tests for Basophil Adenoma

Anatomical Context for Basophil Adenoma

Organs/tissues related to Basophil Adenoma:

MalaCards : Pituitary

Publications for Basophil Adenoma

Articles related to Basophil Adenoma:

(show all 15)
# Title Authors PMID Year
1
Transnasal stereotactic surgery of pituitary adenomas concomitant with acromegaly. 62
8916351 1995
2
Cushing's disease in a young woman with anorexia nervosa: pathophysiological implications. 62
3026602 1986
3
Cyclical Cushing's disease: two distinct rhythms in a patient with a basophil adenoma. 62
2981244 1985
4
Mania in Cushing's syndrome: case report. 62
6317660 1983
5
Cyproheptadine-induced remission of Cushing's disease due to pituitary basophil adenoma. 62
6295736 1982
6
Electroconvulsive therapy following pituitary surgery. 62
41885 1979
7
Pregnancy and Nelson's syndrome. Two case reports. 62
698156 1978
8
Cushing's syndrome, nodular adrenal hyperplasia and virilizing carcinoma. 62
209918 1978
9
[Pituitary adenoma with alpha, 17-39 ACTH and beta, MSH cells, without hypercorticism (author's transl)]. 62
207217 1978
10
Treatment of Nelson's syndrome by pituitary implantation of yttrium-90 or gold-198. 62
182313 1976
11
[Basophil adenoma with slow evolution and virilism]. 62
12980573 1952
12
[Cushing's disease with basophil adenoma]. 62
12994178 1952
13
Pars intermedia basophil adenoma of the hypophysis. 62
19970391 1938
14
BASOPHIL ADENOMA OF THE PITUITARY GLAND WITH RENAL CHANGES. 62
20778876 1935
15
Cardiovascular Renal Changes Associated with Basophil Adenoma of the Anterior Lobe of the Pituitary (Cushing's Syndrome). 62
19970135 1934

Variations for Basophil Adenoma

Expression for Basophil Adenoma

Search GEO for disease gene expression data for Basophil Adenoma.

Pathways for Basophil Adenoma

Pathways related to Basophil Adenoma according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1 13.22 PRKAR1A POMC PDE8B PDE11A GNAS
2
Show member pathways
12.63 PRKAR1A POMC PDE8B PDE11A GNAS
3
Show member pathways
12.22 PRKAR1A POMC GNAS
4
Show member pathways
11.64 PRKAR1A GNAS
5
Show member pathways
11.59 PRKAR1A GNAS
6
Show member pathways
11.57 PRKAR1A GNAS
7 11.47 POMC GNAS
8
Show member pathways
11.45 PRKAR1A GNAS
9 11.42 PRKAR1A GNAS
10
Show member pathways
11.23 PRKAR1A POMC PDE8B PDE11A GNAS
11 11.12 PDE8B PDE11A
12 10.98 PRKAR1A POMC
13 10.91 PRKAR1A GNAS
14 10.7 POMC GNAS
15 10.52 PRKAR1A GNAS

GO Terms for Basophil Adenoma

Biological processes related to Basophil Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cAMP-mediated signaling GO:0043950 8.8 POMC GNAS

Molecular functions related to Basophil Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 3',5'-cyclic-nucleotide phosphodiesterase activity GO:0004114 9.26 PDE8B PDE11A
2 phosphoric diester hydrolase activity GO:0008081 9.16 PDE8B PDE11A
3 3',5'-cyclic-AMP phosphodiesterase activity GO:0004115 8.92 PDE8B PDE11A

Sources for Basophil Adenoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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