MCID: BSS001
MIFTS: 34

Basosquamous Carcinoma

Categories: Cancer diseases, Skin diseases
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Aliases & Classifications for Basosquamous Carcinoma

MalaCards integrated aliases for Basosquamous Carcinoma:

Name: Basosquamous Carcinoma 11 14
Carcinoma, Basosquamous 43 71
Basisquamous Cell Carcinoma 11
Basosquamous Cell Carcinoma 11
Metatypical Carcinoma 11

Classifications:



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Disease Ontology 11 DOID:5063
MeSH 43 D002281
NCIt 49 C2922
SNOMED-CT 68 37304002
UMLS 71 C0007118

Summaries for Basosquamous Carcinoma

MalaCards based summary: Basosquamous Carcinoma, also known as carcinoma, basosquamous, is related to metatypical basal cell carcinoma and basal cell carcinoma 1. An important gene associated with Basosquamous Carcinoma is PTGER4 (Prostaglandin E Receptor 4), and among its related pathways/superpathways are Wnt / Hedgehog / Notch and Development_Hedgehog and PTH signaling pathways in bone and cartilage development. The drugs Nivolumab and Talimogene laherparepvec have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and bone marrow, and related phenotypes are Negative genetic interaction between BLM-/- and BLM+/+ and neoplasm

Related Diseases for Basosquamous Carcinoma

Diseases related to Basosquamous Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 190)
# Related Disease Score Top Affiliating Genes
1 metatypical basal cell carcinoma 31.9 PTGER4 PTCH1 KRT7
2 basal cell carcinoma 1 31.5 PTCH2 PTCH1
3 skin carcinoma 29.9 TP53 PTCH2 PTCH1 KRT7 GLI1
4 basal cell carcinoma 29.9 TP53 PTGER4 PTCH2 PTCH1 KRT7 KRT15
5 basaloid squamous cell carcinoma 29.8 TP53 PTGER4 KRT7
6 muir-torre syndrome 29.8 TP53 PTGER4 KRT7
7 skin benign neoplasm 29.5 TP53 PTCH1 KRT7 GLI1
8 vulva basal cell carcinoma 10.3 PTGER4 PTCH1
9 pigmented basal cell carcinoma 10.3 PTGER4 PTCH1
10 keratosis 10.3
11 actinic keratosis 10.3
12 rare tumor 10.3
13 infiltrative basal cell carcinoma 10.3 PTCH1 KRT15
14 squamous cell carcinoma, head and neck 10.2
15 pericytoma with t(7;12) 10.2 PTCH1 GLI1
16 bartholin's gland adenocarcinoma 10.2 PTGER4 KRT7
17 malignant epithelial mesothelioma 10.2 PTGER4 KRT7
18 rete testis neoplasm 10.2 PTGER4 KRT7
19 rete testis adenocarcinoma 10.2 PTGER4 KRT7
20 nodular hidradenoma 10.2 PTGER4 KRT7
21 pericardial mesothelioma 10.2 PTGER4 KRT7
22 pericardium cancer 10.2 PTGER4 KRT7
23 spiradenoma 10.2 KRT7 KRT15
24 adenoid basal cell carcinoma 10.2 KRT7 KRT15
25 epididymis adenocarcinoma 10.1 PTGER4 KRT7
26 acrocapitofemoral dysplasia 10.1 PTCH1 GLI1
27 epididymis cancer 10.1 PTGER4 KRT7
28 xeroderma pigmentosum, variant type 10.1
29 squamous cell carcinoma 10.1
30 skin squamous cell carcinoma 10.1
31 leishmaniasis 10.1
32 cutaneous leishmaniasis 10.1
33 apocrine sweat gland neoplasm 10.1 KRT7 KRT15
34 benign peritoneal mesothelioma 10.1 PTGER4 KRT7
35 eccrine porocarcinoma 10.1 KRT7 KRT15
36 comedo carcinoma 10.1 TP53 PTGER4
37 chromophil adenoma of the kidney 10.1 PTCH2 KRT7
38 laryngeal neuroendocrine tumor 10.1 TP53 PTCH1
39 polydactyly, postaxial, type a1 10.1 PTCH1 GLI1
40 greig cephalopolysyndactyly syndrome 10.1 PTCH1 GLI1
41 conjunctival squamous cell carcinoma 10.1 TP53 KRT15
42 sebaceous gland neoplasm 10.1 TP53 KRT15
43 polycystic liver disease 1 with or without kidney cysts 10.1 PTCH1 KRT7
44 melanoma 10.1
45 anus basaloid carcinoma 10.0 PTGER4 PTCH1 KRT7
46 inverted follicular keratosis 10.0 PTGER4 PHLDA1
47 skin papilloma 10.0 TP53 KRT15
48 follicular infundibulum tumor 10.0 PHLDA1 KRT15
49 pancreatic foamy gland adenocarcinoma 10.0 TP53 KRT7
50 basal cell carcinoma, infundibulocystic 10.0 PTCH1 PHLDA1

Graphical network of the top 20 diseases related to Basosquamous Carcinoma:



Diseases related to Basosquamous Carcinoma

Symptoms & Phenotypes for Basosquamous Carcinoma

GenomeRNAi Phenotypes related to Basosquamous Carcinoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Negative genetic interaction between BLM-/- and BLM+/+ GR00255-A-1 8.92 KRT15 KRT7 PTCH1 PTCH2

MGI Mouse Phenotypes related to Basosquamous Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.02 GLI1 PTCH1 PTCH2 PTGER4 TP53

Drugs & Therapeutics for Basosquamous Carcinoma

Drugs for Basosquamous Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nivolumab Approved Phase 2 946414-94-4
2
Talimogene laherparepvec Approved, Experimental, Investigational Phase 2 1187560-31-1
3 Immune Checkpoint Inhibitors Phase 2
4 Antineoplastic Agents, Immunological Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Study of Talimogene Laherparepvec Followed by Talimogene Laherparepvec + Nivolumab in Refractory T Cell and NK Cell Lymphomas, Cutaneous Squamous Cell Carcinoma, Merkel Cell Carcinoma, and Other Rare Skin Tumors Recruiting NCT02978625 Phase 2

Search NIH Clinical Center for Basosquamous Carcinoma

Cochrane evidence based reviews: carcinoma, basosquamous

Genetic Tests for Basosquamous Carcinoma

Anatomical Context for Basosquamous Carcinoma

Organs/tissues related to Basosquamous Carcinoma:

MalaCards : Skin, Lymph Node, Bone Marrow, Bone, Endothelial, Eye, Brain

Publications for Basosquamous Carcinoma

Articles related to Basosquamous Carcinoma:

(show top 50) (show all 185)
# Title Authors PMID Year
1
Metastasis of a basosquamous carcinoma arising in a nevus sebaceus. 62
36131688 2022
2
Line-field confocal optical coherence tomography of basosquamous carcinoma: a case series with histopathological correlation. 62
35224784 2022
3
Impressive response to four cemiplimab cycles of a sonidegib-resistant giant basosquamous carcinoma of the midface. 62
35143084 2022
4
Clinical and histopathological profile of primary caruncular lesions. 62
35647965 2022
5
Locally advanced basosquamous carcinoma: Our experience with sonidegib. 62
35278014 2022
6
Position paper on a simplified histopathological classification of basal cell carcinoma: results of the European Consensus Project. 62
34931722 2022
7
Remediation of Mild, Acute Radiation Dermatitis Using a Stem Cell-Based Topical: A Real-World Case Report. 62
35250401 2021
8
Basosquamous Carcinoma: A Commentary. 62
34885255 2021
9
How to spot a basosquamous carcinoma: a study on demographics, clinical-dermatoscopic features and histopathological correlations. 62
34933836 2021
10
Basal cell carcinoma-not always the 'good guy': Case report of a life-threatening basosquamous carcinoma and review of the literature. 62
34504603 2021
11
Eyelid basal cell carcinoma with neuroendocrine differentiation: a case report and literature review. 62
32586182 2021
12
Intra-arterial infusion chemotherapy in the treatment of advanced basosquamous carcinoma of the nose. 62
34307816 2021
13
Skin tumors in xeroderma pigmentosum: Evaluation of a large series and a literature review. 62
33569789 2021
14
Osseointegrated Implants for Orbito-Facial Prostheses: Common Complications and Solutions. 62
33741879 2021
15
Skin shop: long-term management and follow-up of narrowly and incompletely excised non-melanomatous skin cancer. 62
33719193 2021
16
Xeroderma pigmentosum in Yemen. 62
33538348 2021
17
Prompt and safe skin cancer treatment should remain a priority during the pandemic: a rapidly growing basosquamous carcinoma to the tip of the nose in an immunocompromised patient. 62
33622755 2021
18
Reconstruction of Complex Scalp Defects in Different Locations: Suggestions for Puzzle. 62
34712077 2021
19
Interdigitating Dendritic Cell Tumor of Submandibular Lymph Node: Case Report and Literature Review. 62
33936237 2021
20
Characterization of Basosquamous Cell Carcinoma: A Distinct Type of Keratinizing Tumour. 62
33269406 2021
21
Association between periorbital cutaneous leishmaniasis and basosquamous carcinoma. 62
33681937 2021
22
Use of pedicled latissimus dorsi flap in anterior chest wall reconstruction. 62
33436363 2021
23
Cutaneous leishmaniasis dermatoscopically mimicking basosquamous carcinoma in a solid organ transplant recipient. 62
32594633 2020
24
Reappraising basosquamous carcinoma: a summary of histologic features, diagnosis, and treatment. 62
32166375 2020
25
Postauricular Island Flap in Reconstruction of Auricula Tumor Defects. 62
32472892 2020
26
Clinical and epidemiological analysis of basosquamous carcinoma: results of the multicenter study. 62
33116191 2020
27
Novel mutation identified in the DDB2 gene in patients with xeroderma pigmentosum group-E. 62
32530099 2020
28
The Prognostic Value of Podoplanin Expression in Nonmelanoma Skin Cancers: Correlation With Lymphatic Vessel Density. 62
31688008 2020
29
Clinicopathological correlation of malignant skin tumors: A retrospective study of 5 years. 62
32536845 2020
30
Different histopathologic profiles and outcomes between sun-exposed BCC and non-sun-exposed BCC. 62
32355183 2020
31
Basosquamous carcinoma and melanoma collision tumor in a child with xeroderma pigmentosum. 62
31957124 2020
32
Basosquamous carcinoma: epigenetic considerations in a case. 62
32467698 2020
33
Defining the Genetics of Basosquamous Carcinoma. 62
31648686 2019
34
Genetic Mutations Underlying Phenotypic Plasticity in Basosquamous Carcinoma. 62
31207229 2019
35
Surgical Excision with Rotational Flap Reconstruction for Basosquamous Cell Carcinoma in Xeroderma Pigmentosa: A Case Report. 62
31742046 2019
36
Complete response of a locally advanced basosquamous carcinoma with vismodegib treatment. 62
31389370 2019
37
Basosquamous cell carcinoma arising from an infundibular cyst on the hip. 62
30861152 2019
38
Silymarin-loaded nanostructured lipid carrier gel for the treatment of skin cancer. 62
31050580 2019
39
Complete response of locally advanced basosquamous carcinoma to vismodegib in two patients. 62
30998204 2019
40
Customized double-shell immobilization device combined with VMAT radiation treatment of basosquamous cell carcinoma of the scalp. 62
30680884 2019
41
A custom positioning aid for an auricular prosthesis: A clinical report. 62
29961616 2018
42
Degree of differentiation of cutaneous squamous cell carcinoma: a comparison between a Swedish cohort of organ transplant recipients and immunocompetent patients. 62
30479868 2018
43
Detection of Felis catus papillomavirus type 2 within multicentric basosquamous carcinoma in a domestic cat. 62
29998924 2018
44
Sentinel lymph node metastasis in primary cutaneous basosquamous carcinoma. A cross-sectional study. 62
29714816 2018
45
Perineural spread of basosquamous carcinoma to the orbit, cavernous sinus, and infratemporal fossa. 62
29053047 2018
46
Primary basosquamous carcinoma of the lower eyelid with ocular invasion A case report. 62
29626183 2018
47
The curious case of a forehead metatypical basal cell carcinoma. 62
29940648 2018
48
Basal cell carcinoma and basosquamous carcinoma, two faces of the same condition? 62
30534845 2018
49
Basosquamous Carcinoma: A Single Centre Clinicopathological Evaluation and Proposal of an Evidence-Based Protocol. 62
29973992 2018
50
Utilization of Topographical Mohs Micrographic Surgery Maps for Rapid Review of Clinicopathologic Characteristics of Nonmelanoma Skin Cancers of the Ear. 62
28858932 2018

Variations for Basosquamous Carcinoma

Expression for Basosquamous Carcinoma

Search GEO for disease gene expression data for Basosquamous Carcinoma.

Pathways for Basosquamous Carcinoma

GO Terms for Basosquamous Carcinoma

Biological processes related to Basosquamous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of smoothened signaling pathway GO:0008589 9.73 PTCH1 GLI1
2 negative regulation of stem cell proliferation GO:2000647 9.71 TP53 PTCH1
3 cell fate determination GO:0001709 9.67 PTCH2 PTCH1
4 epidermis development GO:0008544 9.62 PTCH2 PTCH1 KRT15
5 prostate gland development GO:0030850 9.56 PTCH1 GLI1
6 smoothened signaling pathway GO:0007224 9.55 PTCH2 PTCH1 GLI1
7 positive regulation of epidermal cell differentiation GO:0045606 9.26 PTCH2 PTCH1
8 epidermal cell fate specification GO:0009957 8.92 PTCH2 PTCH1

Molecular functions related to Basosquamous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hedgehog family protein binding GO:0097108 9.46 PTCH2 PTCH1
2 hedgehog receptor activity GO:0008158 9.26 PTCH2 PTCH1
3 smoothened binding GO:0005119 8.92 PTCH2 PTCH1

Sources for Basosquamous Carcinoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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