MCID: BSS001
MIFTS: 30

Basosquamous Carcinoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Basosquamous Carcinoma

MalaCards integrated aliases for Basosquamous Carcinoma:

Name: Basosquamous Carcinoma 12 15
Carcinoma, Basosquamous 44 70
Basisquamous Cell Carcinoma 12
Basosquamous Cell Carcinoma 12
Metatypical Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5063
MeSH 44 D002281
NCIt 50 C2922
SNOMED-CT 67 37304002
UMLS 70 C0007118

Summaries for Basosquamous Carcinoma

MalaCards based summary : Basosquamous Carcinoma, also known as carcinoma, basosquamous, is related to metatypical basal cell carcinoma and skin carcinoma. An important gene associated with Basosquamous Carcinoma is PTGER4 (Prostaglandin E Receptor 4), and among its related pathways/superpathways are CLEC7A (Dectin-1) signaling and O-linked glycosylation. The drugs Talimogene laherparepvec and nivolumab have been mentioned in the context of this disorder. Affiliated tissues include skin, appendix and lymph node.

Related Diseases for Basosquamous Carcinoma

Diseases related to Basosquamous Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Related Disease Score Top Affiliating Genes
1 metatypical basal cell carcinoma 32.2 PTGER4 PTCH1
2 skin carcinoma 30.1 TP53 PTGER4 PTCH1 KRT17
3 basaloid squamous cell carcinoma 30.0 TP53 KRT17
4 actinic keratosis 29.9 TP53 KRT17
5 keratoacanthoma 29.8 TP53 KRT17
6 basal cell carcinoma 10.7
7 rare tumor 10.3
8 cystic basal cell carcinoma 10.2 PTGER4 PTCH1
9 follicular infundibulum tumor 10.2 PTGER4 KRT17
10 inverted follicular keratosis 10.2 PTGER4 KRT17
11 keratosis 10.2
12 polycystic liver disease 1 with or without kidney cysts 10.1 PTCH1 KRT17
13 tn polyagglutination syndrome 10.1 MUC15 MUC12
14 xeroderma pigmentosum, variant type 10.1
15 kala-azar 1 10.1
16 leishmaniasis 10.1
17 cutaneous leishmaniasis 10.1
18 esophageal basaloid squamous cell carcinoma 10.1 TP53 PTGER4
19 eccrine sweat gland cancer 10.1 TP53 PTGER4
20 malignant spiradenoma 10.1 TP53 PTGER4
21 calcifying epithelial odontogenic tumor 10.1 TP53 PTCH1
22 laryngeal neuroendocrine tumor 10.1 TP53 PTCH1
23 peritoneum cancer 10.1 TP53 PTGER4
24 cerebellum cancer 10.1 TP53 PTCH1
25 sebaceous adenocarcinoma 10.1 TP53 PTGER4
26 keratocystic odontogenic tumor 10.1 TP53 PTCH1
27 acanthoma 10.1 TP53 KRT17
28 ifap syndrome 2 10.0
29 synchronous bilateral breast carcinoma 10.0 TP53 KRT17
30 vulvar dystrophy 10.0 TP53 KRT17
31 muir-torre syndrome 10.0 TP53 PTGER4
32 uterus carcinoma in situ 10.0 TP53 KRT17
33 cervix uteri carcinoma in situ 10.0 TP53 KRT17
34 connective tissue benign neoplasm 10.0 TP53 PTCH1
35 anus cancer 10.0 WDR17 TP53
36 biliary tract benign neoplasm 10.0 TP53 MUC6
37 malignant exocrine pancreas neoplasm 10.0 TP53 MUC6
38 cervical adenoma malignum 10.0 TP53 MUC6
39 benign teratoma 10.0 TP53 PTCH1
40 appendix disease 10.0 TP53 MUC6
41 keratosis, seborrheic 10.0 TP53 KRT17
42 appendix cancer 10.0 TP53 MUC6
43 kearns-sayre syndrome 10.0
44 autosomal recessive disease 10.0
45 ptosis 10.0
46 blind hypotensive eye 10.0
47 allergic disease 10.0
48 telangiectasis 10.0
49 squamous cell carcinoma 10.0
50 optic nerve disease 10.0

Graphical network of the top 20 diseases related to Basosquamous Carcinoma:



Diseases related to Basosquamous Carcinoma

Symptoms & Phenotypes for Basosquamous Carcinoma

Drugs & Therapeutics for Basosquamous Carcinoma

Drugs for Basosquamous Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Talimogene laherparepvec Approved, Experimental, Investigational Phase 2 1187560-31-1
2
nivolumab Approved Phase 2 946414-94-4
3 Antineoplastic Agents, Immunological Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Study of Talimogene Laherparepvec Followed by Talimogene Laherparepvec + Nivolumab in Refractory T Cell and NK Cell Lymphomas, Cutaneous Squamous Cell Carcinoma, Merkel Cell Carcinoma, and Other Rare Skin Tumors Recruiting NCT02978625 Phase 2

Search NIH Clinical Center for Basosquamous Carcinoma

Cochrane evidence based reviews: carcinoma, basosquamous

Genetic Tests for Basosquamous Carcinoma

Anatomical Context for Basosquamous Carcinoma

MalaCards organs/tissues related to Basosquamous Carcinoma:

40
Skin, Appendix, Lymph Node, Bone Marrow, Eye, Cerebellum, Skeletal Muscle

Publications for Basosquamous Carcinoma

Articles related to Basosquamous Carcinoma:

(show top 50) (show all 124)
# Title Authors PMID Year
1
Xeroderma pigmentosum in Yemen. 61
33538348 2021
2
Osseointegrated Implants for Orbito-Facial Prostheses: Common Complications and Solutions. 61
33741879 2021
3
Skin tumors in xeroderma pigmentosum: Evaluation of a large series and a literature review. 61
33569789 2021
4
Prompt and safe skin cancer treatment should remain a priority during the pandemic: a rapidly growing basosquamous carcinoma to the tip of the nose in an immunocompromised patient. 61
33622755 2021
5
Use of pedicled latissimus dorsi flap in anterior chest wall reconstruction. 61
33436363 2021
6
Association between periorbital cutaneous leishmaniasis and basosquamous carcinoma. 61
33681937 2021
7
Characterization of Basosquamous Cell Carcinoma: A Distinct Type of Keratinizing Tumour. 61
33269406 2021
8
Reappraising basosquamous carcinoma: a summary of histologic features, diagnosis, and treatment. 61
32166375 2020
9
Cutaneous leishmaniasis dermatoscopically mimicking basosquamous carcinoma in a solid organ transplant recipient. 61
32594633 2020
10
Postauricular Island Flap in Reconstruction of Auricula Tumor Defects. 61
32472892 2020
11
Clinical and epidemiological analysis of basosquamous carcinoma: results of the multicenter study. 61
33116191 2020
12
The Prognostic Value of Podoplanin Expression in Nonmelanoma Skin Cancers: Correlation With Lymphatic Vessel Density. 61
31688008 2020
13
Clinicopathological correlation of malignant skin tumors: A retrospective study of 5 years. 61
32536845 2020
14
Basosquamous carcinoma and melanoma collision tumor in a child with xeroderma pigmentosum. 61
31957124 2020
15
Basosquamous carcinoma: epigenetic considerations in a case. 61
32467698 2020
16
Defining the Genetics of Basosquamous Carcinoma. 61
31648686 2019
17
Genetic Mutations Underlying Phenotypic Plasticity in Basosquamous Carcinoma. 61
31207229 2019
18
Complete response of a locally advanced basosquamous carcinoma with vismodegib treatment. 61
31389370 2019
19
Silymarin-loaded nanostructured lipid carrier gel for the treatment of skin cancer. 61
31050580 2019
20
Complete response of locally advanced basosquamous carcinoma to vismodegib in two patients. 61
30998204 2019
21
Degree of differentiation of cutaneous squamous cell carcinoma: a comparison between a Swedish cohort of organ transplant recipients and immunocompetent patients. 61
30479868 2018
22
Detection of Felis catus papillomavirus type 2 within multicentric basosquamous carcinoma in a domestic cat. 61
29998924 2018
23
Sentinel lymph node metastasis in primary cutaneous basosquamous carcinoma. A cross-sectional study. 61
29714816 2018
24
Perineural spread of basosquamous carcinoma to the orbit, cavernous sinus, and infratemporal fossa. 61
29053047 2018
25
Primary basosquamous carcinoma of the lower eyelid with ocular invasion A case report. 61
29626183 2018
26
Basal cell carcinoma and basosquamous carcinoma, two faces of the same condition? 61
30534845 2018
27
The curious case of a forehead metatypical basal cell carcinoma. 61
29940648 2018
28
Utilization of Topographical Mohs Micrographic Surgery Maps for Rapid Review of Clinicopathologic Characteristics of Nonmelanoma Skin Cancers of the Ear. 61
28858932 2018
29
Basosquamous Carcinoma: A Single Centre Clinicopathological Evaluation and Proposal of an Evidence-Based Protocol. 61
29973992 2018
30
Reflectance confocal microscopic presentation of basosquamous carcinoma. 61
28622414 2017
31
Toll-Like Receptor 7 Staining in Malignant Epithelial Tumors. 61
28857981 2017
32
Ulcerated Metatypical Basal Cell Carcinoma of the Forehead. 61
29104696 2017
33
Primary myxoid melanoma with dermoscopic findings. 61
28515997 2017
34
Basosquamous carcinoma: Dermoscopic clues to diagnosis. 61
27570202 2017
35
Basosquamous Carcinoma: Controversy, Advances, and Future Directions. 61
27340741 2017
36
Basosquamous carcinoma: appearance and reality. 61
28058108 2017
37
Metastatic Basosquamous Carcinoma: Report of Two Cases and Clinicopathological Considerations. 61
27235385 2016
38
Rescue therapy with anti-programmed cell death protein 1 inhibitors of advanced cutaneous squamous cell carcinoma and basosquamous carcinoma: preliminary experience in five cases. 61
27059424 2016
39
Primary cutaneous malignancies in the Northern Cape Province of South Africa: A retrospective histopathological review. 61
28112098 2016
40
Facial extensive ulcer. 61
27008486 2016
41
Host immune responses and peritumoral stromal reactions in different basal cell carcinoma subtypes: histopathological comparison of basosquamous carcinoma and high-risk and low-risk basal cell carcinoma subtypes. 61
27511329 2016
42
[The role of dermoscopy in the diagnosis of basosquamous carcinoma]. 61
28293368 2016
43
Basosquamous Carcinoma Masquerading as Angiolymphoid Hyperplasia. 61
26955161 2016
44
Case of basosquamous carcinoma: Dermoscopic and immunohistochemical findings. 61
26211637 2015
45
Nonmelanoma cutaneous cancers involving the skull base: outcomes of aggressive multimodal management. 61
25909577 2015
46
Basal cell carcinoma: clinical and pathological features. 61
26099353 2015
47
Basosquamous carcinoma: is it an aggressive tumor? 61
25139415 2015
48
Basosquamous carcinoma of the head and neck: clinical and histologic characteristics and their impact on disease progression. 61
25810014 2015
49
The Effects of Cyclin D1 and Bcl-2 Expressıon on Aggressive Behavior in Basal Cell and Basosquamous Carcinoma. 61
26351483 2015
50
Basal cell carcinomas in a tertiary referral centre: a systematic analysis. 61
24974741 2014

Variations for Basosquamous Carcinoma

Expression for Basosquamous Carcinoma

Search GEO for disease gene expression data for Basosquamous Carcinoma.

Pathways for Basosquamous Carcinoma

GO Terms for Basosquamous Carcinoma

Cellular components related to Basosquamous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi lumen GO:0005796 8.92 MUC6 MUC20 MUC15 MUC12

Biological processes related to Basosquamous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.26 MUC6 MUC20 MUC15 MUC12
2 embryonic organ development GO:0048568 9.16 TP53 PTCH1
3 O-glycan processing GO:0016266 8.92 MUC6 MUC20 MUC15 MUC12

Sources for Basosquamous Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....