MCID: BCK005
MIFTS: 35

Becker Nevus Syndrome

Categories: Fetal diseases, Rare diseases, Reproductive diseases, Skin diseases

Aliases & Classifications for Becker Nevus Syndrome

MalaCards integrated aliases for Becker Nevus Syndrome:

Name: Becker Nevus Syndrome 57 53 59 73
Becker's Nevus 76 53
Pigmentary Hairy Epidermal Nevus 59
Pigmented Hairy Epidermal Nevus 73
Hairy Epidermal Nevus Syndrome 53
Becker's Melanosis 73
Becker Melanosis 53
Becker Naevus 53
Becker Nevus 53

Classifications:



External Ids:

OMIM 57 604919
Orphanet 59 ORPHA64755
UMLS via Orphanet 74 C0263579 C1858042
ICD10 via Orphanet 34 D22.5
MedGen 42 C1858042

Summaries for Becker Nevus Syndrome

NIH Rare Diseases : 53 Becker nevus syndrome is characterized by the presence of a Becker nevus in association with underdevelopment (hypoplasia) of the breast or other skin-related, muscular, or skeletal defects, all of which usually involve the same side of the body as the nevus (ipsilateral). Specific signs and symptoms in addition to the nevus may include ipsilateral breast hypoplasia; skeletal abnormalities such as hypoplasia of the shoulder girdle, scoliosis, fused ribs, and ipsilateral shortness of the arm; and several other features. The condition is thought to be sporadic (occurring in individuals with no history of the condition in the family). Treatment varies depending upon the specific symptoms present and the extent of the condition in the affected individual.

MalaCards based summary : Becker Nevus Syndrome, also known as becker's nevus, is related to congenital heart defects, hamartomas of tongue, and polysyndactyly and neurofibroma. An important gene associated with Becker Nevus Syndrome is ACTB (Actin Beta). Affiliated tissues include skin, breast and bone, and related phenotypes are pectus excavatum and scoliosis

Wikipedia : 76 Becker''s nevus (also known as "Becker''s melanosis", "Becker''s pigmentary hamartoma", "nevoid... more...

Description from OMIM: 604919

Related Diseases for Becker Nevus Syndrome

Diseases related to Becker Nevus Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.0
2 neurofibroma 10.0
3 nipples, supernumerary 10.0
4 neurofibromatosis, type ii 10.0
5 kabuki syndrome 1 10.0
6 nevus anemicus 10.0
7 desmoid tumor 10.0

Graphical network of the top 20 diseases related to Becker Nevus Syndrome:



Diseases related to Becker Nevus Syndrome

Symptoms & Phenotypes for Becker Nevus Syndrome

Clinical features from OMIM:

604919

Human phenotypes related to Becker Nevus Syndrome:

59 32 (show all 20)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 pectus excavatum 59 32 frequent (33%) Frequent (79-30%) HP:0000767
2 scoliosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0002650
3 kyphosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0002808
4 pectus carinatum 59 32 frequent (33%) Frequent (79-30%) HP:0000768
5 lipoatrophy 59 32 hallmark (90%) Very frequent (99-80%) HP:0100578
6 micromelia 59 32 hallmark (90%) Very frequent (99-80%) HP:0002983
7 spina bifida occulta 59 32 occasional (7.5%) Occasional (29-5%) HP:0003298
8 hypermelanotic macule 59 32 hallmark (90%) Very frequent (99-80%) HP:0001034
9 lower limb asymmetry 59 32 occasional (7.5%) Occasional (29-5%) HP:0100559
10 rib fusion 59 32 occasional (7.5%) Occasional (29-5%) HP:0000902
11 supernumerary ribs 59 32 occasional (7.5%) Occasional (29-5%) HP:0005815
12 supernumerary nipple 59 32 hallmark (90%) Very frequent (99-80%) HP:0002558
13 abnormality of tibia morphology 59 32 occasional (7.5%) Occasional (29-5%) HP:0002992
14 upper limb asymmetry 59 32 occasional (7.5%) Occasional (29-5%) HP:0100560
15 hamartoma 59 32 hallmark (90%) Very frequent (99-80%) HP:0010566
16 abnormality of the scrotum 59 32 occasional (7.5%) Occasional (29-5%) HP:0000045
17 aplasia/hypoplasia of the breasts 59 32 frequent (33%) Frequent (79-30%) HP:0010311
18 hypoplastic labia minora 59 32 occasional (7.5%) Occasional (29-5%) HP:0000064
19 shoulder girdle muscle atrophy 59 32 hallmark (90%) Very frequent (99-80%) HP:0003724
20 nevus 32 HP:0003764

Drugs & Therapeutics for Becker Nevus Syndrome

Search Clinical Trials , NIH Clinical Center for Becker Nevus Syndrome

Genetic Tests for Becker Nevus Syndrome

Anatomical Context for Becker Nevus Syndrome

MalaCards organs/tissues related to Becker Nevus Syndrome:

41
Skin, Breast, Bone, Smooth Muscle

Publications for Becker Nevus Syndrome

Articles related to Becker Nevus Syndrome:

(show all 41)
# Title Authors Year
1
Becker's Nevus with Recurrent Eczema Limited to the Nevus Lesion. ( 29386838 )
2018
2
Successful treatment of Becker's Nevus with long-pulsed 1064-nm Nd:YAG and 755-nm alexandrite laser and review of the literature. ( 28498021 )
2018
3
Clinicopathologic characteristics of early-onset Becker's nevus in Korean children and adolescents. ( 29090468 )
2018
4
Lightening Becker's nevus: Role of topical therapies. ( 30195570 )
2018
5
Treatment of Breast Hypoplasia in Becker Nevus Syndrome. ( 28295908 )
2017
6
Becker's nevus associated with basal cell carcinoma: an unusual presentation in a sun-protected area. ( 28225979 )
2017
7
Becker's nevus syndrome: a report of a rare disease with unusual associations. ( 27655000 )
2017
8
An unusual case of phakomatosis pigmentovascularis type IIb with Becker's nevus. ( 27694062 )
2017
9
Postzygotic Mutations in Beta-Actin Are Associated with Becker's Nevus and Becker's Nevus Syndrome. ( 28347698 )
2017
10
Some Becker's Nevus Melanocytes Remain Alive after Treatment with Q-Switched Alexandrite Laser. ( 28566917 )
2017
11
Becker's Nevus and Lethal Beta-Actin Mutations. ( 28625464 )
2017
12
Efficacy and safety of short-pulse erbium: Yttrium aluminum garnet laser treatment of Becker's nevus in Saudi patients: A pilot study. ( 28936145 )
2017
13
Becker Nevus Syndrome of the Lower Body: One Case and Review of the Literature. ( 27882383 )
2016
14
Asymmetrical growth of beard due to Becker's nevus on the face: a rare presentation. ( 24981788 )
2016
15
Becker's nevus among siblings. ( 27088958 )
2016
16
Giant bilateral Becker's nevus appearing as gladiator arm armor. ( 27559520 )
2016
17
Becker's Nevus Syndrome in a Pediatric Female Patient. ( 27891278 )
2016
18
Clinicopathological Features and Immunohistochemical Alterations of Keratinocyte Proliferation, Melanocyte Density, Smooth Muscle Hyperplasia and Nerve Fiber Distribution in Becker's Nevus. ( 27904268 )
2016
19
Breast lipofilling: A new treatment of Becker nevus syndrome. ( 25746302 )
2015
20
Becker's nevus with neurofibromatosis type 1. ( 25745321 )
2015
21
Sebaceus and Becker's Nevus: Overview of Their Presentation, Pathogenesis, Associations, and Treatment. ( 25782676 )
2015
22
Images in clinical medicine. Becker's nevus. ( 25806917 )
2015
23
Acquired linear Becker's nevus on lower limb in blaschkoid pattern. ( 25851753 )
2015
24
Becker's nevus. ( 25991871 )
2015
25
Becker's nevus syndrome. ( 26265883 )
2015
26
Bilateral Symmetrical Congenital Giant Becker's Nevus: A Rare Presentation. ( 26538733 )
2015
27
[The interesting case: unilateral hypoplasia of the breast in Becker nevus syndrome]. ( 25162246 )
2014
28
Becker nevus syndrome; probably the first report of concurrent acrally located congenital BN, soft tissue hypertrophy and fused carpal bones. ( 25176291 )
2014
29
Becker nevus syndrome presented with ipsilateral breast hypoplasia. ( 25484431 )
2014
30
Becker's Nevus Syndrome. ( 25071279 )
2014
31
Pigmented epithelioid melanocytoma developed in a patient with Becker nevus syndrome. ( 22452553 )
2012
32
Do you know this syndrome? Becker nevus syndrome. ( 21437545 )
2011
33
Patient with giant Becker's nevus and epidermal nevus. ( 25386275 )
2011
34
Becker nevus syndrome. ( 20676475 )
2010
35
Becker's nevus syndrome revisited. ( 15583590 )
2004
36
Paradominant inheritance, supernumerary nipples and Becker's nevus: once again! ( 11701421 )
2001
37
Simultaneous occurrence of segmental odontomaxillary dysplasia and Becker's nevus. ( 10513874 )
1999
38
Becker nevus syndrome and supernumerary nipples. ( 9557900 )
1998
39
Supernumerary nipple in association with Becker nevus vs. Becker nevus syndrome: a semantic problem only. ( 9557899 )
1998
40
Becker nevus syndrome. ( 9024572 )
1997
41
Lymphangioma associated with Becker's nevus: a report of coincident hamartomas in a child. ( 9336810 )
1997

Variations for Becker Nevus Syndrome

Expression for Becker Nevus Syndrome

Search GEO for disease gene expression data for Becker Nevus Syndrome.

Pathways for Becker Nevus Syndrome

GO Terms for Becker Nevus Syndrome

Sources for Becker Nevus Syndrome

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69 SNOMED-CT via HPO
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71 TGDB
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74 UMLS via Orphanet
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