MCID: BCK005
MIFTS: 37

Becker Nevus Syndrome

Categories: Fetal diseases, Rare diseases, Reproductive diseases, Skin diseases

Aliases & Classifications for Becker Nevus Syndrome

MalaCards integrated aliases for Becker Nevus Syndrome:

Name: Becker Nevus Syndrome 58 54 60 74
Becker's Nevus 77 54
Pigmentary Hairy Epidermal Nevus 60
Pigmented Hairy Epidermal Nevus 74
Hairy Epidermal Nevus Syndrome 54
Becker's Melanosis 74
Becker Melanosis 54
Becker Naevus 54
Becker Nevus 54

Classifications:



External Ids:

OMIM 58 604919
ICD10 via Orphanet 35 D22.5
UMLS via Orphanet 75 C0263579 C1858042
Orphanet 60 ORPHA64755
MedGen 43 C1858042

Summaries for Becker Nevus Syndrome

NIH Rare Diseases : 54 Becker nevus syndrome is characterized by the presence of a Becker nevus in association with underdevelopment (hypoplasia) of the breast or other skin-related, muscular, or skeletal defects, all of which usually involve the same side of the body as the nevus (ipsilateral). Specific signs and symptoms in addition to the nevus may include ipsilateral breast hypoplasia; skeletal abnormalities such as hypoplasia of the shoulder girdle, scoliosis, fused ribs, and ipsilateral shortness of the arm; and several other features. The condition is thought to be sporadic (occurring in individuals with no history of the condition in the family). Treatment varies depending upon the specific symptoms present and the extent of the condition in the affected individual.

MalaCards based summary : Becker Nevus Syndrome, also known as becker's nevus, is related to hypertrichosis and congenital heart defects, hamartomas of tongue, and polysyndactyly. An important gene associated with Becker Nevus Syndrome is ACTB (Actin Beta). The drugs Triamcinolone and Hydroquinone have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and bone, and related phenotypes are lipoatrophy and micromelia

Wikipedia : 77 Becker''s nevus (also known as "Becker''s melanosis", "Becker''s pigmentary hamartoma", "nevoid... more...

Description from OMIM: 604919

Related Diseases for Becker Nevus Syndrome

Graphical network of the top 20 diseases related to Becker Nevus Syndrome:



Diseases related to Becker Nevus Syndrome

Symptoms & Phenotypes for Becker Nevus Syndrome

Human phenotypes related to Becker Nevus Syndrome:

60 33 (show all 20)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 lipoatrophy 60 33 hallmark (90%) Very frequent (99-80%) HP:0100578
2 micromelia 60 33 hallmark (90%) Very frequent (99-80%) HP:0002983
3 hypermelanotic macule 60 33 hallmark (90%) Very frequent (99-80%) HP:0001034
4 supernumerary nipple 60 33 hallmark (90%) Very frequent (99-80%) HP:0002558
5 hamartoma 60 33 hallmark (90%) Very frequent (99-80%) HP:0010566
6 shoulder girdle muscle atrophy 60 33 hallmark (90%) Very frequent (99-80%) HP:0003724
7 pectus excavatum 60 33 frequent (33%) Frequent (79-30%) HP:0000767
8 pectus carinatum 60 33 frequent (33%) Frequent (79-30%) HP:0000768
9 aplasia/hypoplasia of the breasts 60 33 frequent (33%) Frequent (79-30%) HP:0010311
10 scoliosis 60 33 occasional (7.5%) Occasional (29-5%) HP:0002650
11 kyphosis 60 33 occasional (7.5%) Occasional (29-5%) HP:0002808
12 spina bifida occulta 60 33 occasional (7.5%) Occasional (29-5%) HP:0003298
13 lower limb asymmetry 60 33 occasional (7.5%) Occasional (29-5%) HP:0100559
14 rib fusion 60 33 occasional (7.5%) Occasional (29-5%) HP:0000902
15 supernumerary ribs 60 33 occasional (7.5%) Occasional (29-5%) HP:0005815
16 abnormality of tibia morphology 60 33 occasional (7.5%) Occasional (29-5%) HP:0002992
17 upper limb asymmetry 60 33 occasional (7.5%) Occasional (29-5%) HP:0100560
18 abnormality of the scrotum 60 33 occasional (7.5%) Occasional (29-5%) HP:0000045
19 hypoplastic labia minora 60 33 occasional (7.5%) Occasional (29-5%) HP:0000064
20 nevus 33 HP:0003764

Clinical features from OMIM:

604919

Drugs & Therapeutics for Becker Nevus Syndrome

Drugs for Becker Nevus Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Triamcinolone Approved, Vet_approved Phase 2 124-94-7 31307
2
Hydroquinone Approved, Investigational Phase 2 123-31-9 785
3
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 5538 444795
4 Triamcinolone hexacetonide Phase 2
5 Anti-Inflammatory Agents Phase 2
6 Hormones Phase 2
7 Immunosuppressive Agents Phase 2
8 Hormone Antagonists Phase 2
9 Immunologic Factors Phase 2
10 Triamcinolone diacetate Phase 2
11 triamcinolone acetonide Phase 2
12 glucocorticoids Phase 2
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Fractional Laser as Treatment Option for Various Pigment Disorders Completed NCT01083498 Phase 2

Search NIH Clinical Center for Becker Nevus Syndrome

Genetic Tests for Becker Nevus Syndrome

Anatomical Context for Becker Nevus Syndrome

MalaCards organs/tissues related to Becker Nevus Syndrome:

42
Skin, Breast, Bone, Smooth Muscle

Publications for Becker Nevus Syndrome

Articles related to Becker Nevus Syndrome:

(show all 38)
# Title Authors Year
1
Becker's nevus syndrome. ( 30650953 )
2019
2
Lasers for Becker's nevus. ( 30762191 )
2019
3
Becker's Nevus with Recurrent Eczema Limited to the Nevus Lesion. ( 29386838 )
2018
4
Successful treatment of Becker's Nevus with long-pulsed 1064-nm Nd:YAG and 755-nm alexandrite laser and review of the literature. ( 28498021 )
2018
5
Clinicopathologic characteristics of early-onset Becker's nevus in Korean children and adolescents. ( 29090468 )
2018
6
Treatment of Breast Hypoplasia in Becker Nevus Syndrome. ( 28295908 )
2017
7
Becker's nevus associated with basal cell carcinoma: an unusual presentation in a sun-protected area. ( 28225979 )
2017
8
Postzygotic Mutations in Beta-Actin Are Associated with Becker's Nevus and Becker's Nevus Syndrome. ( 28347698 )
2017
9
Some Becker's Nevus Melanocytes Remain Alive after Treatment with Q-Switched Alexandrite Laser. ( 28566917 )
2017
10
Becker's Nevus and Lethal Beta-Actin Mutations. ( 28625464 )
2017
11
Efficacy and safety of short-pulse erbium: Yttrium aluminum garnet laser treatment of Becker's nevus in Saudi patients: A pilot study. ( 28936145 )
2017
12
Becker's nevus syndrome: a report of a rare disease with unusual associations. ( 27655000 )
2017
13
An unusual case of phakomatosis pigmentovascularis type IIb with Becker's nevus. ( 27694062 )
2017
14
Becker Nevus Syndrome of the Lower Body: One Case and Review of the Literature. ( 27882383 )
2016
15
Clinicopathological Features and Immunohistochemical Alterations of Keratinocyte Proliferation, Melanocyte Density, Smooth Muscle Hyperplasia and Nerve Fiber Distribution in Becker's Nevus. ( 27904268 )
2016
16
Asymmetrical growth of beard due to Becker's nevus on the face: a rare presentation. ( 24981788 )
2016
17
Becker's nevus among siblings. ( 27088958 )
2016
18
Giant bilateral Becker's nevus appearing as gladiator arm armor. ( 27559520 )
2016
19
Becker's Nevus Syndrome in a Pediatric Female Patient. ( 27891278 )
2016
20
Breast lipofilling: A new treatment of Becker nevus syndrome. ( 25746302 )
2015
21
Becker's nevus with neurofibromatosis type 1. ( 25745321 )
2015
22
Sebaceus and Becker's Nevus: Overview of Their Presentation, Pathogenesis, Associations, and Treatment. ( 25782676 )
2015
23
Images in clinical medicine. Becker's nevus. ( 25806917 )
2015
24
Acquired linear Becker's nevus on lower limb in blaschkoid pattern. ( 25851753 )
2015
25
Becker's nevus. ( 25991871 )
2015
26
Becker's nevus syndrome. ( 26265883 )
2015
27
Bilateral Symmetrical Congenital Giant Becker's Nevus: A Rare Presentation. ( 26538733 )
2015
28
[The interesting case: unilateral hypoplasia of the breast in Becker nevus syndrome]. ( 25162246 )
2014
29
Becker nevus syndrome; probably the first report of concurrent acrally located congenital BN, soft tissue hypertrophy and fused carpal bones. ( 25176291 )
2014
30
Becker nevus syndrome presented with ipsilateral breast hypoplasia. ( 25484431 )
2014
31
Becker's Nevus Syndrome. ( 25071279 )
2014
32
Pigmented epithelioid melanocytoma developed in a patient with Becker nevus syndrome. ( 22452553 )
2012
33
Do you know this syndrome? Becker nevus syndrome. ( 21437545 )
2011
34
Patient with giant Becker's nevus and epidermal nevus. ( 25386275 )
2011
35
Becker nevus syndrome. ( 20676475 )
2010
36
Becker nevus syndrome and supernumerary nipples. ( 9557900 )
1998
37
Supernumerary nipple in association with Becker nevus vs. Becker nevus syndrome: a semantic problem only. ( 9557899 )
1998
38
Becker nevus syndrome. ( 9024572 )
1997

Variations for Becker Nevus Syndrome

Expression for Becker Nevus Syndrome

Search GEO for disease gene expression data for Becker Nevus Syndrome.

Pathways for Becker Nevus Syndrome

GO Terms for Becker Nevus Syndrome

Sources for Becker Nevus Syndrome

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35 ICD10 via Orphanet
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63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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