MCID: BCK005
MIFTS: 33

Becker Nevus Syndrome

Categories: Fetal diseases, Rare diseases, Reproductive diseases, Skin diseases

Aliases & Classifications for Becker Nevus Syndrome

MalaCards integrated aliases for Becker Nevus Syndrome:

Name: Becker Nevus Syndrome 56 52 58 71
Becker's Nevus 74 52
Pigmentary Hairy Epidermal Nevus 58
Pigmented Hairy Epidermal Nevus 71
Hairy Epidermal Nevus Syndrome 52
Becker's Melanosis 71
Becker Melanosis 52
Becker Naevus 52
Becker Nevus 52

Classifications:

Orphanet: 58  
Rare gynaecological and obstetric diseases
Rare skin diseases
Developmental anomalies during embryogenesis


External Ids:

OMIM 56 604919
ICD10 via Orphanet 33 D22.5
UMLS via Orphanet 72 C0263579 C1858042
Orphanet 58 ORPHA64755
MedGen 41 C1858042
UMLS 71 C0263579 C0544863 C1858042

Summaries for Becker Nevus Syndrome

NIH Rare Diseases : 52 Becker nevus syndrome is characterized by the presence of a Becker nevus in association with underdevelopment (hypoplasia) of the breast or other skin-related, muscular, or skeletal defects, all of which usually involve the same side of the body as the nevus (ipsilateral). Specific signs and symptoms in addition to the nevus may include ipsilateral breast hypoplasia; skeletal abnormalities such as hypoplasia of the shoulder girdle, scoliosis , fused ribs, and ipsilateral shortness of the arm; and several other features. The condition is thought to be sporadic (occurring in individuals with no history of the condition in the family). Treatment varies depending upon the specific symptoms present and the extent of the condition in the affected individual.

MalaCards based summary : Becker Nevus Syndrome, also known as becker's nevus, is related to hypertrichosis and neurofibromatosis, type iv, of riccardi. An important gene associated with Becker Nevus Syndrome is ACTB (Actin Beta). The drugs Hydroquinone and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and smooth muscle, and related phenotypes are lipoatrophy and hypermelanotic macule

Wikipedia : 74 Becker's nevus (also known as "Becker's melanosis", "Becker's pigmentary hamartoma", "nevoid melanosis",... more...

More information from OMIM: 604919

Related Diseases for Becker Nevus Syndrome

Diseases related to Becker Nevus Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 hypertrichosis 10.6
2 neurofibromatosis, type iv, of riccardi 10.3
3 dermatitis 10.3
4 nevus, epidermal 10.3
5 scoliosis 10.3
6 neurofibromatosis, type ii 10.2
7 lentigines 10.2
8 keratosis 10.2
9 melanoma 10.2
10 folliculitis 10.2
11 phacomatosis pigmentovascularis 10.2
12 acanthosis nigricans 10.1
13 mastocytosis, cutaneous 10.1
14 melanoma, cutaneous malignant 1 10.1
15 lipoid congenital adrenal hyperplasia 10.1
16 orthostatic intolerance 10.1
17 retinal dystrophy, iris coloboma, and comedogenic acne syndrome 10.1
18 nevus comedonicus 10.1
19 dysplastic nevus syndrome 10.1
20 leiomyoma 10.1
21 lymphangioma 10.1
22 urticaria 10.1
23 ichthyosis 10.1
24 basal cell carcinoma 10.1
25 cystic lymphangioma 10.1
26 leiomyoma cutis 10.1
27 plexiform neurofibroma 10.1
28 skin melanoma 10.1
29 pityriasis versicolor 10.1
30 lichen planus 10.1
31 neurofibroma 10.1
32 47,xyy 10.1
33 dwarfism 10.1
34 prurigo nodularis 10.1
35 nevus of ota 10.1
36 congenital smooth muscle hamartoma 10.1
37 rare lymphatic malformation 10.1
38 segmental odontomaxillary dysplasia 10.1
39 nipples, supernumerary 10.0
40 dowling-degos disease 1 10.0
41 neural tube defects 10.0
42 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.0
43 spina bifida occulta 10.0
44 papilloma 10.0
45 kabuki syndrome 1 10.0
46 nevus anemicus 10.0
47 vitiligo-associated multiple autoimmune disease susceptibility 6 10.0
48 vitiligo-associated multiple autoimmune disease susceptibility 1 10.0
49 desmoid tumor 10.0
50 allergic hypersensitivity disease 10.0

Graphical network of the top 20 diseases related to Becker Nevus Syndrome:



Diseases related to Becker Nevus Syndrome

Symptoms & Phenotypes for Becker Nevus Syndrome

Human phenotypes related to Becker Nevus Syndrome:

58 31 (show all 20)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 lipoatrophy 58 31 hallmark (90%) Very frequent (99-80%) HP:0100578
2 hypermelanotic macule 58 31 hallmark (90%) Very frequent (99-80%) HP:0001034
3 micromelia 58 31 hallmark (90%) Very frequent (99-80%) HP:0002983
4 supernumerary nipple 58 31 hallmark (90%) Very frequent (99-80%) HP:0002558
5 hamartoma 58 31 hallmark (90%) Very frequent (99-80%) HP:0010566
6 shoulder girdle muscle atrophy 58 31 hallmark (90%) Very frequent (99-80%) HP:0003724
7 pectus excavatum 58 31 frequent (33%) Frequent (79-30%) HP:0000767
8 pectus carinatum 58 31 frequent (33%) Frequent (79-30%) HP:0000768
9 aplasia/hypoplasia of the breasts 58 31 frequent (33%) Frequent (79-30%) HP:0010311
10 scoliosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002650
11 kyphosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002808
12 supernumerary ribs 58 31 occasional (7.5%) Occasional (29-5%) HP:0005815
13 abnormality of tibia morphology 58 31 occasional (7.5%) Occasional (29-5%) HP:0002992
14 hypoplastic labia minora 58 31 occasional (7.5%) Occasional (29-5%) HP:0000064
15 spina bifida occulta 58 31 occasional (7.5%) Occasional (29-5%) HP:0003298
16 rib fusion 58 31 occasional (7.5%) Occasional (29-5%) HP:0000902
17 lower limb asymmetry 58 31 occasional (7.5%) Occasional (29-5%) HP:0100559
18 upper limb asymmetry 58 31 occasional (7.5%) Occasional (29-5%) HP:0100560
19 abnormality of the scrotum 58 31 occasional (7.5%) Occasional (29-5%) HP:0000045
20 nevus 31 HP:0003764

Clinical features from OMIM:

604919

Drugs & Therapeutics for Becker Nevus Syndrome

Drugs for Becker Nevus Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydroquinone Approved, Investigational Phase 2 123-31-9 785
2
Triamcinolone Approved, Vet_approved Phase 2 124-94-7 31307
3
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 5538 444795
4 Triamcinolone hexacetonide Phase 2
5 triamcinolone acetonide Phase 2
6 Triamcinolone diacetate Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Ablative Fractional Laser Therapy as Treatment for Becker's Nevus; a Pilot Study Completed NCT01083498 Phase 2

Search NIH Clinical Center for Becker Nevus Syndrome

Genetic Tests for Becker Nevus Syndrome

Anatomical Context for Becker Nevus Syndrome

MalaCards organs/tissues related to Becker Nevus Syndrome:

40
Skin, Breast, Smooth Muscle, Tongue, Bone, Heart

Publications for Becker Nevus Syndrome

Articles related to Becker Nevus Syndrome:

(show top 50) (show all 152)
# Title Authors PMID Year
1
Becker nevus syndrome. 61 56
9024572 1997
2
Epidermal nevus syndromes. 56
7640190 1995
3
Neurofibromatosis Type 1 with Becker's Nevus and Nevus of Ota. 61
32029954 2020
4
The co-existence of cutaneous melanoma and urticaria pigmentosa in a patient with Becker's nevus. 61
31803997 2019
5
Becker's nevus syndrome. 61
31297897 2019
6
Intense pulsed light treatment for Becker's nevus. 61
31416363 2019
7
Lasers for Becker's nevus. 61
30762191 2019
8
Becker's nevus syndrome. 61
30650953 2019
9
A Rare Case of Checkerboard-Like Becker Nevi with a Unique Distribution of Abnormalities. 61
31218086 2019
10
Multiple bilateral Becker's nevus in a Saudi female: a rare presentation. 61
31872177 2019
11
Successful treatment of Becker's Nevus with long-pulsed 1064-nm Nd:YAG and 755-nm alexandrite laser and review of the literature. 61
28498021 2018
12
Becker's Nevus with Recurrent Eczema Limited to the Nevus Lesion. 61
29386838 2018
13
Clinicopathologic characteristics of early-onset Becker's nevus in Korean children and adolescents. 61
29090468 2018
14
Epidermal nevus syndromes: New insights into whorls and swirls. 61
29044700 2018
15
Giant congenital Becker's nevus overlying a plexiform neurofibroma: Merely a coincidence or more than it? 61
29210362 2017
16
[Smooth muscle hamartoma in volar skin]. 61
28812115 2017
17
Becker's nevus in neurofibromatosis type 1: a single center experience in Italy. 61
28906096 2017
18
Treatment of Breast Hypoplasia in Becker Nevus Syndrome. 61
28295908 2017
19
Becker's Nevus and Lethal Beta-Actin Mutations. 61
28625464 2017
20
Postzygotic Mutations in Beta-Actin Are Associated with Becker's Nevus and Becker's Nevus Syndrome. 61
28347698 2017
21
Efficacy and safety of short-pulse erbium: Yttrium aluminum garnet laser treatment of Becker's nevus in Saudi patients: A pilot study. 61
28936145 2017
22
Some Becker's Nevus Melanocytes Remain Alive after Treatment with Q-Switched Alexandrite Laser. 61
28566917 2017
23
Becker's nevus syndrome: a report of a rare disease with unusual associations. 61
27655000 2017
24
An unusual case of phakomatosis pigmentovascularis type IIb with Becker's nevus. 61
27694062 2017
25
Becker's nevus associated with basal cell carcinoma: an unusual presentation in a sun-protected area. 61
28225979 2017
26
Clinicopathological Features and Immunohistochemical Alterations of Keratinocyte Proliferation, Melanocyte Density, Smooth Muscle Hyperplasia and Nerve Fiber Distribution in Becker's Nevus. 61
27904268 2016
27
Constituents of Cryptotaenia japonica Inhibit Melanogenesis via CREB- and MAPK-Associated Signaling Pathways in Murine B16 Melanoma Cells. 61
27689982 2016
28
Giant bilateral Becker's nevus appearing as gladiator arm armor. 61
27559520 2016
29
Becker's nevus among siblings. 61
27088958 2016
30
Hypertrichotic Becker's nevi treated with combination 1,550 nm non-ablative fractional photothermolysis and laser hair removal. 61
26996148 2016
31
Treatment of pigmentary disorders in patients with skin of color with a novel 755 nm picosecond, Q-switched ruby, and Q-switched Nd:YAG nanosecond lasers: A retrospective photographic review. 61
26922302 2016
32
A retrospective analysis on the management of pigmented lesions using a picosecond 755-nm alexandrite laser in Asians. 61
26696500 2016
33
Becker's Nevus Syndrome in a Pediatric Female Patient. 61
27891278 2016
34
Asymmetrical growth of beard due to Becker's nevus on the face: a rare presentation. 61
24981788 2016
35
Becker nevus syndrome; probably the first report of concurrent acrally located congenital BN, soft tissue hypertrophy and fused carpal bones. 61
25176291 2016
36
Mosaic Neurocutaneous Disorders and Their Causes. 61
26706010 2015
37
Becker's nevus. 61
25991871 2015
38
NEVUS DEPIGMENTOSUS ASSOCIATED WITH NEVUS SPILUS: FIRST REPORT IN THE WORLD LITERATURE. 61
26656555 2015
39
Bilateral Symmetrical Congenital Giant Becker's Nevus: A Rare Presentation. 61
26538733 2015
40
Breast lipofilling: A new treatment of Becker nevus syndrome. 61
25746302 2015
41
Becker's nevus syndrome. 61
26265883 2015
42
Sebaceus and Becker's Nevus: Overview of Their Presentation, Pathogenesis, Associations, and Treatment. 61
25782676 2015
43
Acquired linear Becker's nevus on lower limb in blaschkoid pattern. 61
25851753 2015
44
Images in clinical medicine. Becker's nevus. 61
25806917 2015
45
Becker's nevus with neurofibromatosis type 1. 61
25745321 2015
46
Epidermal nevus syndromes. 61
26564089 2015
47
A case of Becker's nevus with pityriasis versicolor. 61
24438156 2014
48
Becker nevus syndrome presented with ipsilateral breast hypoplasia. 61
25484431 2014
49
[The interesting case: unilateral hypoplasia of the breast in Becker nevus syndrome]. 61
25162246 2014
50
[Becker's nevus]. 61
24955912 2014

Variations for Becker Nevus Syndrome

Expression for Becker Nevus Syndrome

Search GEO for disease gene expression data for Becker Nevus Syndrome.

Pathways for Becker Nevus Syndrome

GO Terms for Becker Nevus Syndrome

Sources for Becker Nevus Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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