BEJEL
MCID: BJL001
MIFTS: 32

Bejel (BEJEL)

Categories: Bone diseases, Infectious diseases, Oral diseases, Rare diseases, Skin diseases

Aliases & Classifications for Bejel

MalaCards integrated aliases for Bejel:

Name: Bejel 12 74 52 15 71
Nonvenereal Endemic Syphilis 12 74
Treponemal Infections 43 71
Nonvenereal Syphilis 52 32
Dichuchwa 52 71
Njovera 12 52
Non-Venereal Endemic Syphilis 71
Endemic Syphilis 52
Frenga 52

Classifications:



External Ids:

Disease Ontology 12 DOID:13431
MeSH 43 D014211
ICD10 32 A65
UMLS 71 C0004945 C0040843 C0343841 more

Summaries for Bejel

Disease Ontology : 12 A primary bacterial infectious disease that results in infection located in mucosa of mouth, located in skin or located in bone, has material basis in Treponema pallidum subsp endemicum, which is transmitted by contact or transmitted by sharing of domestic utensils. The infection has symptom moist patches in the mouth, has symptom lumps in long bones, tissues around the mouth, nose, and roof of the mouth. These lumps destroy tissue, causing bones to be deformed and disfiguring the face.

MalaCards based summary : Bejel, also known as nonvenereal endemic syphilis, is related to syphilis and yaws. An important gene associated with Bejel is TPR (Translocated Promoter Region, Nuclear Basket Protein). The drugs Procaine and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and testes, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 74 Bejel, or endemic syphilis, is a chronic skin and tissue disease caused by infection by the endemicum... more...

Related Diseases for Bejel

Graphical network of the top 20 diseases related to Bejel:



Diseases related to Bejel

Symptoms & Phenotypes for Bejel

GenomeRNAi Phenotypes related to Bejel according to GeneCards Suite gene sharing:

26 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.58 RNF112 TPR
2 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.58 TPR
3 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.58 RNF112
4 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.58 RNF112
5 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.58 RNF112
6 Increased shRNA abundance (Z-score > 2) GR00366-A-205 9.58 RNF112 TPR
7 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.58 RNF112
8 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.58 RNF112
9 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.58 RNF112
10 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.58 RNF112
11 Increased shRNA abundance (Z-score > 2) GR00366-A-60 9.58 TPR
12 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.58 RNF112
13 Increased shRNA abundance (Z-score > 2) GR00366-A-82 9.58 RNF112
14 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.58 TPR
15 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.58 RNF112
16 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.58 RNF112

Drugs & Therapeutics for Bejel

Drugs for Bejel (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Procaine Approved, Investigational, Vet_approved Phase 3 59-46-1 4914
2
Azithromycin Approved Phase 3 83905-01-5 55185 447043
3
carbamide peroxide Approved Phase 3 124-43-6
4
Penicillin G Approved, Vet_approved Phase 3 61-33-6 5904
5 Anti-Bacterial Agents Phase 3
6 Anti-Infective Agents Phase 3
7 penicillins Phase 3
8 Penicillin G Benzathine Phase 3
9 Penicillin G Procaine Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Single-dose Azithromycin Versus Penicillin G Benzathine for the Treatment of Yaws in Children Completed NCT01382004 Phase 3 Penicillin-G-benzathine;Azithromycin

Search NIH Clinical Center for Bejel

Cochrane evidence based reviews: treponemal infections

Genetic Tests for Bejel

Anatomical Context for Bejel

MalaCards organs/tissues related to Bejel:

40
Skin, Bone, Testes, T Cells

Publications for Bejel

Articles related to Bejel:

(show top 50) (show all 129)
# Title Authors PMID Year
1
The pan-genome of Treponema pallidum reveals differences in genome plasticity between subspecies related to venereal and non-venereal syphilis. 61
31924165 2020
2
Advancing the understanding of treponemal disease in the past and present. 61
31956996 2020
3
The "Scourge of the Renaissance". A short review about Treponema pallidum infection. 61
31625831 2019
4
Dual screen and confirm rapid test does not reduce overtreatment of syphilis in pregnant women living in a non-venereal treponematoses endemic region: a field evaluation among antenatal care attendees in Burkina Faso. 61
30580325 2019
5
Bejel, a Nonvenereal Treponematosis, among Men Who Have Sex with Men, Japan. 61
31310214 2019
6
Identification of positively selected genes in human pathogenic treponemes: Syphilis-, yaws-, and bejel-causing strains differ in sets of genes showing adaptive evolution. 61
31216284 2019
7
Bejel in Cuba: molecular identification of Treponema pallidum subsp. endemicum in patients diagnosed with venereal syphilis. 61
29454847 2018
8
Genetics of human and animal uncultivable treponemal pathogens. 61
29578082 2018
9
Point-of-care tests for syphilis and yaws in a low-income setting - A qualitative study of healthcare worker and patient experiences. 61
29672524 2018
10
First Paleogenetic Evidence of Probable Syphilis and Treponematoses Cases in the Brazilian Colonial Period. 61
30406142 2018
11
Survey of Treponemal Infections in Free-Ranging and Captive Macaques, 1999-2012. 61
28418297 2017
12
Functional clues from the crystal structure of an orphan periplasmic ligand-binding protein from Treponema pallidum. 61
28168761 2017
13
Human Treponema pallidum 11q/j isolate belongs to subsp. endemicum but contains two loci with a sequence in TP0548 and TP0488 similar to subsp. pertenue and subsp. pallidum, respectively. 61
28263990 2017
14
Between Colonial, National, and International Medicine: The Case of Bejel. 61
29276190 2017
15
Performance of Syphilis Sentinel Surveillance in the context of endemic Treponematoses: experience from Ghana. 61
27938337 2016
16
Pinta: Latin America's Forgotten Disease? 61
26304920 2015
17
Molecular differentiation of Treponema pallidum subspecies in skin ulceration clinically suspected as yaws in Vanuatu using real-time multiplex PCR and serological methods. 61
25404075 2015
18
A Retrospective Study on Genetic Heterogeneity within Treponema Strains: Subpopulations Are Genetically Distinct in a Limited Number of Positions. 61
26436423 2015
19
Endemic treponemal diseases. 61
25157125 2014
20
Syphilis-causing strains belong to separate SS14-like or Nichols-like groups as defined by multilocus analysis of 19 Treponema pallidum strains. 61
24841252 2014
21
The endemic treponematoses. 61
24396138 2014
22
Whole genome sequence of the Treponema pallidum subsp. endemicum strain Bosnia A: the genome is related to yaws treponemes but contains few loci similar to syphilis treponemes. 61
25375929 2014
23
Advances in the diagnosis of endemic treponematoses: yaws, bejel, and pinta. 61
24205410 2013
24
Treponemal infection in free-ranging European brown hares (Lepus europaeus) in central Italy: serology and epidemiology. 61
23060513 2012
25
Genetic diversity in Treponema pallidum: implications for pathogenesis, evolution and molecular diagnostics of syphilis and yaws. 61
22198325 2012
26
Treponema infection associated with genital ulceration in wild baboons. 61
21411621 2012
27
Treponema pallidum infection in the wild baboons of East Africa: distribution and genetic characterization of the strains responsible. 61
23284649 2012
28
Endemic treponemal infections in international adoptees and immigrant children: how common are they? 61
21504459 2011
29
Climate and New World periosteal reaction patterns: implications for migration routes into the western hemisphere. 61
20481062 2009
30
The sequence of the acidic repeat protein (arp) gene differentiates venereal from nonvenereal Treponema pallidum subspecies, and the gene has evolved under strong positive selection in the subspecies that causes syphilis. 61
18554302 2008
31
Isolation and laboratory maintenance of Treponema pallidum. 61
18770607 2007
32
Bejel: acquirable only in childhood? 61
17049474 2006
33
[A comparative study of the emergence of the AIDS and syphilis pandemics]. 61
17446154 2006
34
Endemic treponematosis: review and update. 61
16714199 2006
35
Regional, social, and evolutionary perspectives on treponemal infection in the Southeastern United States. 61
16345066 2006
36
[Overview of endemic treponematoses]. 61
16615610 2006
37
History of syphilis. 61
15844068 2005
38
[Interpretation of questionable syphilis serologies]. 61
15109173 2004
39
Treponemal infections in the pediatric population. 61
11173204 2000
40
First European exposure to syphilis: the Dominican Republic at the time of Columbian contact. 61
11049773 2000
41
[Bejel: an unusual cause of stomatitis in the child]. 61
10095894 1999
42
The flanking region sequences of the 15-kDa lipoprotein gene differentiate pathogenic treponemes. 61
9534979 1998
43
Seroepidemiology of HIV, HBV, HCV and treponemal infections. 61
9842162 1998
44
[Identification of a focus of bejel in Mauritania]. 61
10088115 1998
45
[Serologic studies of non-venereal treponematoses in infants in Niamey, Niger]. 61
9718553 1998
46
Sexually transmitted diseases in domestic expatriate workers in Jeddah, Saudi Arabia. 61
17377460 1997
47
Serologic tests for treponematoses in the United Arab Emirates. 61
8915734 1996
48
Evaluation of cerebrospinal fluid in Southeast Asian refugees with reactive serologic tests for syphilis. 61
8993199 1996
49
Seroprevalences of Toxoplasma, malaria, rubella, cytomegalovirus, HIV and treponemal infections among pregnant women in Cotonou, Republic of Benin. 61
8533662 1995
50
Treponemal disease revisited: skeletal discriminators for yaws, bejel, and venereal syphilis. 61
7620034 1995

Variations for Bejel

Expression for Bejel

Search GEO for disease gene expression data for Bejel.

Pathways for Bejel

GO Terms for Bejel

Cellular components related to Bejel according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extrinsic component of membrane GO:0019898 8.62 TPR RNF112

Biological processes related to Bejel according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron projection morphogenesis GO:0048812 8.96 NCKAP1L EPB41L3
2 cortical actin cytoskeleton organization GO:0030866 8.62 NCKAP1L EPB41L3

Sources for Bejel

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10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
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30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
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48 NCI
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50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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