BEJEL
MCID: BJL001
MIFTS: 28

Bejel (BEJEL)

Categories: Bone diseases, Infectious diseases, Oral diseases, Rare diseases, Skin diseases

Aliases & Classifications for Bejel

MalaCards integrated aliases for Bejel:

Name: Bejel 12 75 53 15 72
Nonvenereal Endemic Syphilis 12 75
Treponemal Infections 44 72
Nonvenereal Syphilis 53 33
Dichuchwa 53 72
Njovera 12 53
Non-Venereal Endemic Syphilis 72
Endemic Syphilis 53
Frenga 53

Classifications:



External Ids:

Disease Ontology 12 DOID:13431
MeSH 44 D014211
ICD10 33 A65
UMLS 72 C0004945 C0040843 C0343841 more

Summaries for Bejel

Disease Ontology : 12 A primary bacterial infectious disease that results in infection located in mucosa of mouth, located in skin or located in bone, has material basis in Treponema pallidum subsp endemicum, which is transmitted by contact or transmitted by sharing of domestic utensils. The infection has symptom moist patches in the mouth, has symptom lumps in long bones, tissues around the mouth, nose, and roof of the mouth. These lumps destroy tissue, causing bones to be deformed and disfiguring the face.

MalaCards based summary : Bejel, also known as nonvenereal endemic syphilis, is related to yaws and syphilis. An important gene associated with Bejel is EPB41L3 (Erythrocyte Membrane Protein Band 4.1 Like 3). The drugs Penicillin G and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and testes.

Wikipedia : 75 Bejel, or endemic syphilis, is a chronic skin and tissue disease caused by infection by the endemicum... more...

Related Diseases for Bejel

Graphical network of the top 20 diseases related to Bejel:



Diseases related to Bejel

Symptoms & Phenotypes for Bejel

Drugs & Therapeutics for Bejel

DrugBank drugs 16 :

# Drug Name Indication DrugBank ID
1 Procaine benzylpenicillin For the treatment of a number of bacterial infections such as syphilis, anthrax, mouth infections, pneumonia and diphtheria. DB09320

Drugs for Bejel (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Penicillin G Approved, Vet_approved Phase 3 61-33-6 5904
2
Azithromycin Approved Phase 3 83905-01-5 447043 55185
3
carbamide peroxide Approved Phase 3 124-43-6
4
Procaine Approved, Investigational, Vet_approved Phase 3 59-46-1 4914
5 penicillins Phase 3
6 Anti-Bacterial Agents Phase 3
7 Anti-Infective Agents Phase 3
8 Penicillin G Procaine Phase 3
9 Penicillin G Benzathine Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Single-dose Azithromycin Versus Penicillin G Benzathine for the Treatment of Yaws in Children Completed NCT01382004 Phase 3 Penicillin-G-benzathine;Azithromycin

Search NIH Clinical Center for Bejel

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Procaine benzylpenicillin

Cochrane evidence based reviews: treponemal infections

Genetic Tests for Bejel

Anatomical Context for Bejel

MalaCards organs/tissues related to Bejel:

41
Skin, Bone, Testes

Publications for Bejel

Articles related to Bejel:

(show top 50) (show all 126)
# Title Authors PMID Year
1
Dual screen and confirm rapid test does not reduce overtreatment of syphilis in pregnant women living in a non-venereal treponematoses endemic region: a field evaluation among antenatal care attendees in Burkina Faso. 38
30580325 2019
2
Bejel, a Nonvenereal Treponematosis, among Men Who Have Sex with Men, Japan. 38
31310214 2019
3
Identification of positively selected genes in human pathogenic treponemes: Syphilis-, yaws-, and bejel-causing strains differ in sets of genes showing adaptive evolution. 38
31216284 2019
4
Bejel in Cuba: molecular identification of Treponema pallidum subsp. endemicum in patients diagnosed with venereal syphilis. 38
29454847 2018
5
Genetics of human and animal uncultivable treponemal pathogens. 38
29578082 2018
6
Point-of-care tests for syphilis and yaws in a low-income setting - A qualitative study of healthcare worker and patient experiences. 38
29672524 2018
7
First Paleogenetic Evidence of Probable Syphilis and Treponematoses Cases in the Brazilian Colonial Period. 38
30406142 2018
8
Survey of Treponemal Infections in Free-Ranging and Captive Macaques, 1999-2012. 38
28418297 2017
9
Functional clues from the crystal structure of an orphan periplasmic ligand-binding protein from Treponema pallidum. 38
28168761 2017
10
Human Treponema pallidum 11q/j isolate belongs to subsp. endemicum but contains two loci with a sequence in TP0548 and TP0488 similar to subsp. pertenue and subsp. pallidum, respectively. 38
28263990 2017
11
Between Colonial, National, and International Medicine: The Case of Bejel. 38
29276190 2017
12
Performance of Syphilis Sentinel Surveillance in the context of endemic Treponematoses: experience from Ghana. 38
27938337 2016
13
Pinta: Latin America's Forgotten Disease? 38
26304920 2015
14
Molecular differentiation of Treponema pallidum subspecies in skin ulceration clinically suspected as yaws in Vanuatu using real-time multiplex PCR and serological methods. 38
25404075 2015
15
A Retrospective Study on Genetic Heterogeneity within Treponema Strains: Subpopulations Are Genetically Distinct in a Limited Number of Positions. 38
26436423 2015
16
Endemic treponemal diseases. 38
25157125 2014
17
Syphilis-causing strains belong to separate SS14-like or Nichols-like groups as defined by multilocus analysis of 19 Treponema pallidum strains. 38
24841252 2014
18
Whole genome sequence of the Treponema pallidum subsp. endemicum strain Bosnia A: the genome is related to yaws treponemes but contains few loci similar to syphilis treponemes. 38
25375929 2014
19
The endemic treponematoses. 38
24396138 2014
20
Advances in the diagnosis of endemic treponematoses: yaws, bejel, and pinta. 38
24205410 2013
21
Treponemal infection in free-ranging European brown hares (Lepus europaeus) in central Italy: serology and epidemiology. 38
23060513 2012
22
Genetic diversity in Treponema pallidum: implications for pathogenesis, evolution and molecular diagnostics of syphilis and yaws. 38
22198325 2012
23
Treponema infection associated with genital ulceration in wild baboons. 38
21411621 2012
24
Treponema pallidum infection in the wild baboons of East Africa: distribution and genetic characterization of the strains responsible. 38
23284649 2012
25
Endemic treponemal infections in international adoptees and immigrant children: how common are they? 38
21504459 2011
26
Climate and New World periosteal reaction patterns: implications for migration routes into the western hemisphere. 38
20481062 2009
27
The sequence of the acidic repeat protein (arp) gene differentiates venereal from nonvenereal Treponema pallidum subspecies, and the gene has evolved under strong positive selection in the subspecies that causes syphilis. 38
18554302 2008
28
Isolation and laboratory maintenance of Treponema pallidum. 38
18770607 2007
29
Bejel: acquirable only in childhood? 38
17049474 2006
30
[A comparative study of the emergence of the AIDS and syphilis pandemics]. 38
17446154 2006
31
Endemic treponematosis: review and update. 38
16714199 2006
32
Regional, social, and evolutionary perspectives on treponemal infection in the Southeastern United States. 38
16345066 2006
33
[Overview of endemic treponematoses]. 38
16615610 2006
34
History of syphilis. 38
15844068 2005
35
[Interpretation of questionable syphilis serologies]. 38
15109173 2004
36
Treponemal infections in the pediatric population. 38
11173204 2000
37
First European exposure to syphilis: the Dominican Republic at the time of Columbian contact. 38
11049773 2000
38
[Bejel: an unusual cause of stomatitis in the child]. 38
10095894 1999
39
The flanking region sequences of the 15-kDa lipoprotein gene differentiate pathogenic treponemes. 38
9534979 1998
40
Seroepidemiology of HIV, HBV, HCV and treponemal infections. 38
9842162 1998
41
[Identification of a focus of bejel in Mauritania]. 38
10088115 1998
42
[Serologic studies of non-venereal treponematoses in infants in Niamey, Niger]. 38
9718553 1998
43
Sexually transmitted diseases in domestic expatriate workers in Jeddah, Saudi Arabia. 38
17377460 1997
44
Serologic tests for treponematoses in the United Arab Emirates. 38
8915734 1996
45
Evaluation of cerebrospinal fluid in Southeast Asian refugees with reactive serologic tests for syphilis. 38
8993199 1996
46
Seroprevalences of Toxoplasma, malaria, rubella, cytomegalovirus, HIV and treponemal infections among pregnant women in Cotonou, Republic of Benin. 38
8533662 1995
47
Treponemal disease revisited: skeletal discriminators for yaws, bejel, and venereal syphilis. 38
7620034 1995
48
IgA antiphospholipid antibodies in HTLV-1-associated tropical spastic paraparesis. 38
7795617 1995
49
Bejel in Malatya, Turkey. 38
7776395 1995
50
[Case for diagnosis. Bejel]. 38
8572499 1995

Variations for Bejel

Expression for Bejel

Search GEO for disease gene expression data for Bejel.

Pathways for Bejel

GO Terms for Bejel

Sources for Bejel

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
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44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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