Bell's Palsy disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: BLL003 MIFTS: 53	Bell's Palsy Categories: Eye diseases, Infectious diseases, Neuronal diseases, Rare diseases, Smell/Taste diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Bell's Palsy

MalaCards integrated aliases for Bell's Palsy:

Name: Bell's Palsy ¹¹ ¹⁹ ⁵² ⁷⁵ ⁵ ⁴¹ ¹⁴ ¹⁶

Bell Palsy ¹¹ ¹⁹ ⁴³ ⁷¹ ³¹ ³³

Facial Nerve Palsy ¹⁹ ³³

Facial Paralysis ¹⁹ ⁷¹

Facial Palsy ¹⁹ ³³

Seventh Cranial Nerve Paralysis ³³

Facial Cranial Nerve Paralysis ¹⁹

Idiopathic Facial Palsy ¹⁹

Facial Nerve Paralysis ³³

Refrigeration Palsy ¹⁹

Face Paralysis Nos ³³

Bell's Palsy ¹¹

Antoni's Palsy ¹⁹

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Neuronal diseases Eye diseases Smell/Taste diseases

See all MalaCards categories (disease lists)

ICD10: ³¹

Diseases of the nervous system

Nerve, nerve root and plexus disorders

Facial nerve disorders

Bell palsy

ICD11: ³³

Diseases of the nervous system

Disorders of nerve root, plexus or peripheral nerves

Disorders of cranial nerves

Disorders of facial nerve

Bell palsy

External Ids:

Disease Ontology ¹¹ DOID:12506

ICD9CM ³⁴ 351.0

MeSH ⁴³ D020330

SNOMED-CT ⁶⁸ 193093009

ICD10 ³¹ G51.0

EFO ¹⁶ EFO_0007167

ICD11 ³³ 2004402146

UMLS ⁷¹ C0015469 C0376175

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Summaries for Bell's Palsy

NINDS: ⁵² Bell's palsy is a form of temporary facial paralysis resulting from damage or trauma to the 7th cranial nerve, one of the facial nerves. It is the most common cause of facial paralysis. Generally, Bell's palsy affects only one side of the face, but it can affect both sides. Symptoms vary among individuals and include sudden weakness on one side of the face, drooping eyelid or corner of the mouth, drooling, inability to close the eye or mouth, altered taste, and excessive tearing in the eye. Symptoms appear suddenly and reach their peak within 72 hours. Bell's palsy can range in severity from mild weakness to total paralysis, and can cause significant facial distortion. The exact cause of Bell's palsy isn't known, but many scientists believe that reactivation of a dormant viral infection can cause the facial nerve to swell and become inflamed. Several other conditions can cause facial paralysis that might be diagnosed as Bell's palsy. The disorder can affect anyone at any age. Risk factors include pregnancy, preeclampsia, obesity, hypertention, diabetes, and upper respiratory ailments.

MalaCards based summary: Bell's Palsy, also known as bell palsy, is related to lyme disease and herpes zoster, and has symptoms including tremor, muscle weakness and back pain. An important gene associated with Bell's Palsy is MARVELD1 (MARVEL Domain Containing 1), and among its related pathways/superpathways are Hematopoietic Stem Cells and Lineage-specific Markers and Th17 Differentiation. The drugs Valaciclovir and Acetylcholine have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and salivary gland, and related phenotype is cellular.

MedlinePlus: ⁴¹ Bell's palsy is the most common cause of facial paralysis. It usually affects just one side of the face. Symptoms appear suddenly and are at their worst about 48 hours after they start. They can range from mild to severe and include: Twitching Weakness Paralysis Drooping eyelid or corner of mouth Drooling Dry eye or mouth Excessive tearing in the eye Impaired ability to taste Scientists think that a viral infection makes the facial nerve swell or become inflamed. You are most likely to get Bell's palsy if you are pregnant, diabetic or sick with a cold or flu. Three out of four patients improve without treatment. With or without treatment, most people begin to get better within 2 weeks and recover completely within 3 to 6 months. NIH: National Institute of Neurological Disorders and Stroke

GARD: ¹⁹ Bell's palsy is a form of temporary facial paralysis which results from damage or trauma to one of the facial nerves. Symptoms vary, but may include twitching, weakness, drooping eyelid or corner of the mouth, drooling, dry eye or mouth, impairment of taste, and excessive tearing in the eye. The exact cause is unknown.

Disease Ontology: ¹¹ A facial paralysis resulting from dysfunction in the cranial nerve VII (facial nerve).

Wikipedia: ⁷⁵ Bell's palsy is a type of facial paralysis that results in a temporary inability to control the facial... more...

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Related Diseases for Bell's Palsy

Diseases related to Bell's Palsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1486)

#	Related Disease	Score	Top Affiliating Genes
1	lyme disease	31.6	TNF IL6 CRP
2	herpes zoster	31.3	TLR3 CD8A CD4
3	melkersson-rosenthal syndrome	30.6	TNF CRP ACE
4	intracranial abscess	30.6	CRP CD4
5	pfeiffer syndrome	30.5	TNF CRP CD8A CD4
6	guillain-barre syndrome	30.5	TNF MBP ALB
7	brain stem infarction	30.5	LIPN CRP
8	pityriasis rosea	30.4	CD8A CD4 ACE2
9	uveoparotid fever	30.4	CD4 ACE
10	mononeuritis multiplex	30.3	TNF CRP CD4
11	syphilitic meningitis	30.3	CRP CD4
12	hepatitis e	30.3	TNF TLR3 ALB
13	tick-borne encephalitis	30.2	TLR3 CD8A CD4
14	multiple cranial nerve palsy	30.2	CRP CD4 ACE
15	neuritis	30.2	TNF MBP IL6
16	panniculitis	30.2	CRP CD8A CD4
17	central nervous system tuberculosis	30.1	TNF CRP CD4
18	tuberculoid leprosy	30.1	TNF CD8A CD4
19	parotitis	30.1	CRP CD8A CD4 ALB
20	lepromatous leprosy	30.1	TNF CD8A CD4
21	cerebellopontine angle tumor	30.1	KANTR FKBP4
22	severe acute respiratory syndrome	30.1	TNF IL6 CRP ACE2 ACE
23	viral infectious disease	30.1	TNF TLR3 IL6 CD4 ACE2
24	cavernous sinus thrombosis	30.0	CRP CD4 ACE2
25	hypertensive encephalopathy	30.0	CRP ALB ACE
26	tolosa-hunt syndrome	30.0	CRP ACE
27	hepatitis a	30.0	TNF TLR3 CD4 ALB
28	cat-scratch disease	30.0	CRP CD4 ACE
29	otitis media	30.0	TNF IL6 CRP ALB
30	covid-19	29.9	TNF IL6 CRP ACE2 ACE
31	neuroretinitis	29.9	CRP CD4 ACE
32	xerophthalmia	29.9	TNF MTRNR2L5 CRP CD8A CD4
33	eclampsia	29.9	TNF IL6 ALB ACE
34	abducens palsy	29.9	KANTR CRP
35	granulomatosis with polyangiitis	29.9	TNF CRP CD8A CD4
36	superior mesenteric artery syndrome	29.9	CRP ALB
37	osteomyelitis	29.9	TNF IL6 CRP
38	nerve compression syndrome	29.9	LIPN IL6 CRP ALB
39	vitiligo-associated multiple autoimmune disease susceptibility 1	29.8	TNF CD8A CD4
40	pre-eclampsia	29.8	TNF IL6 CRP ALB ACE
41	chlamydia	29.8	TNF IL6 CRP
42	renal hypertension	29.8	CRP ALB ACE
43	polyarteritis nodosa	29.8	TNF IL6 CRP
44	aortic valve insufficiency	29.8	CRP ALB ACE
45	otitis externa	29.8	IL6 CRP CD4
46	amyloidosis	29.8	TNF IL6 CRP ALB
47	mononeuropathy	29.8	TNF IL6 CRP CD4 ALB ACE
48	rubella	29.8	TNF TLR3 IL6
49	human cytomegalovirus infection	29.7	TNF IL6 CD8A CD4
50	japanese encephalitis	29.7	TLR3 CD8A CD4

Graphical network of the top 20 diseases related to Bell's Palsy:

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Symptoms & Phenotypes for Bell's Palsy

UMLS symptoms related to Bell's Palsy:

tremor; muscle weakness; back pain; ophthalmoplegia; headache; syncope; generalized muscle weakness; hemiplegia; pain; chronic pain; sciatica; seizures; vertigo/dizziness; sleeplessness; oral manifestations; facial paresis; facial palsy, upper motor neuron; facial palsy, lower motor neuron; hemifacial paralysis; flaccid muscle tone

MGI Mouse Phenotypes related to Bell's Palsy:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	9.36	ACE ACE2 ALB CD4 CD8A FKBP4

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Drugs & Therapeutics for Bell's Palsy

Drugs for Bell's Palsy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 64)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Valaciclovir

Approved, Investigational

Phase 4

124832-27-5, 124832-26-4

60773 135398742

Acetylcholine

Approved, Investigational

Phase 4

51-84-3

187

Prednisolone phosphate

Approved, Vet_approved

Phase 4

302-25-0

Prednisolone acetate

Approved, Vet_approved

Phase 4

52-21-1

Prednisolone

Approved, Vet_approved

Phase 4

50-24-8

4894 5755

Methylprednisolone hemisuccinate

Approved

Phase 4

2921-57-5

1875

Methylprednisolone

Approved, Vet_approved

Phase 4

83-43-2

4159 6741

Apraclonidine

Approved

Phase 4

66711-21-5

2216

Lidocaine

Approved, Vet_approved

Phase 4

137-58-6

3676

Prednisolone hemisuccinate

Experimental

Phase 4

2920-86-7

4897

Cortisone

Experimental

Phase 4

53-06-5

222786

Neuroprotective Agents

Phase 4

Antiemetics

Phase 4

Gastrointestinal Agents

Phase 4

abobotulinumtoxinA

Phase 4

Botulinum Toxins, Type A

Phase 4

Botulinum Toxins

Phase 4

incobotulinumtoxinA

Phase 4

Cholinergic Agents

Phase 4

Antineoplastic Agents, Hormonal

Phase 4

Hormones

Phase 4

Hormone Antagonists

Phase 4

glucocorticoids

Phase 4

Anti-Inflammatory Agents

Phase 4

Methylprednisolone Acetate

Phase 4

584547

Neurotransmitter Agents

Phase 4

Adrenergic alpha-Agonists

Phase 4

Adrenergic Agonists

Phase 4

Adrenergic Agents

Phase 4

Anesthetics

Phase 4

Anti-Arrhythmia Agents

Phase 4

Sodium Channel Blockers

Phase 4

Anesthetics, Local

Phase 4

Diuretics, Potassium Sparing

Phase 4

Dexamethasone acetate

Approved, Investigational, Vet_approved

Phase 2, Phase 3

1177-87-3

3680

Dexamethasone

Approved, Investigational, Vet_approved

Phase 2, Phase 3

50-02-2

3003 5743

Phenol

Approved, Experimental

Phase 2, Phase 3

108-95-2

996

Benzocaine

Approved, Investigational

Phase 2, Phase 3

1994-09-7, 94-09-7

2337

Tannic acid

Approved

Phase 2, Phase 3

1401-55-4

16129878 16129778

Pharmaceutical Solutions

Phase 2, Phase 3

Hyaluronic acid

Approved, Vet_approved

Phase 2

9004-61-9

53477741

Nimodipine

Approved, Investigational

Phase 2

66085-59-4

4497

Protective Agents

Phase 2

Adjuvants, Immunologic

Phase 2

Viscosupplements

Phase 2

Immunologic Factors

Phase 2

Antihypertensive Agents

Phase 2

Vasodilator Agents

Phase 2

Calcium, Dietary

Phase 2

calcium channel blockers

Phase 2

Interventional clinical trials:

(show top 50) (show all 75)

#	Name	Status	NCT ID	Phase	Drugs
1	A Multicentre Placebo-Controlled Evaluation of Prednisolone and/or Valaciclovir for the Treatment of Bell's Palsy	Completed	NCT00510263	Phase 4	Prednisolone + placebo;Valaciclovir + placebo;Prednisolone + valaciclovir;Placebo + placebo
2	Mixed Methods Investigation of Chronic Facial Paralysis in Individuals With Synkinesis: Study of Outcomes Before and After Treatment	Completed	NCT04148872	Phase 4	Chemodenervation (4 months)
3	Randomized, Single-blind Comparison of Three Commercially Available Botulinum Neuromodulators in the Management of Facial Synkinesis	Completed	NCT03048383	Phase 4	OnabotulinumtoxinA Injectable Product;AbobotulinumtoxinA Injectable Product;Incobotulinumtoxin A Injectable Product
4	Do We Need to Taper Down Steroid Therapy for Bell's Palsy: A Prospective Randomized Controlled Trial	Recruiting	NCT04406376	Phase 4	Prednisone tablet
5	The Facial Nerve Palsy And Cortisone Evaluation (FACE) Study in Children: A Randomized Double-blind, Placebo-controlled, Multicenter Trial	Recruiting	NCT03781700	Phase 4	Prednisolone;Placebo Oral Tablet
6	Efficacy of Topical Apraclonidine for the Treatment of Ocular Synkinesis	Not yet recruiting	NCT05167760	Phase 4	Apraclonidine
7	Study of the Reinnervation of Facial Muscles After Lengthening Temporalis Myoplasty	Terminated	NCT01833221	Phase 4	injection of 1% lidocaine, 2mL for facial nerve block
8	Assessment of Corticosteroid Effect in the Prevention of Facial Palsy After Cerebella-pontine Angle Surgery	Completed	NCT00438087	Phase 3	methylprednisolone
9	Intratympanic Steroid Injection for Treatment of Idiopathic Facial Nerve Paralysis	Recruiting	NCT03508440	Phase 2, Phase 3	Prednisone
10	A Phase 2a, Multicenter, Randomized, Subject and Evaluator Blinded, Controlled Study Evaluating the Safety and Efficacy of NTX-001 Compared to Standard of Care in the Treatment and Prevention of Facial Paralysis Requiring Surgical Repair.	Recruiting	NCT05293522	Phase 2
11	Clinical, Instrumental and Histological Evaluation of the Combined Use of Onabotulinumtoxin A and Hyaluronic Acid Fillers in Patients With Facial Paralysis	Recruiting	NCT05012566	Phase 2	Vistabex
12	Intraoperative Application of Nimodipine to the Facial and Cochlear Nerves During Vestibular Schwannoma Resection to Avoid Spasm-related Postoperative Facial Paralysis and Deafness - a Prospective Randomized Pilot Study	Recruiting	NCT04801953	Phase 2	NiMODipine Injectable Solution
13	Mimetic Interfaces - Toispuoleisen Kasvohermohalvauksen Kojeellinen Kuntoutus Terveen Puolen Lihasaktiviteettiohjauksella. Stimulaattorin Prototyypin Testaus terveillä koehenkilöillä ja Kasvohermohalvauspotilailla.	Unknown status	NCT03496025	Phase 1
14	Prednisone Acetate and Acupuncture for the Treatment of Facial Neuritis: a Multiple Center, Comparative Effectiveness Research in China	Unknown status	NCT01201642		Prednisolone
15	Study of Psychological Factors on the Occurence of Bell's Palsy	Unknown status	NCT01377766
16	Surgery or Clinical Follow-up in Patients With Bell's Palsy. A Prospective, Parallell, Single Center, Randomized , Open Surgery Clinical Study.	Unknown status	NCT02179684
17	Intratympanic Stereoidal Injections for Facial Nerve Palsy	Unknown status	NCT03371589		Dexamethasone
18	Ancillary Procedures in Patients of Refractory Facial Palsy Patients Selection and Evaluation of the Outcomes	Unknown status	NCT04237961
19	Validation of a French-language Version of Specific Quality of Life Questionnaires in Patients With Peripheral Facial Palsy	Unknown status	NCT03581253
20	Comparative Study of Peripheral Facial Paralysis Sequelae Based on the Initial Medical Care of Lyme Disease Among Children	Unknown status	NCT03981874
21	Reliability of Multislice Computed Tomography Scan in Cases With Facial Nerve Paralysis Due to Temporal Bone Trauma	Unknown status	NCT03469427
22	Photobiomodulation Therapy for Idiopathic Facial Paralysis: Randomized Trial Controlled	Completed	NCT05585346		Prednisolone Acetate
23	Study of Effects of Deqi and Neuropsychological Factors on Acupuncture Effects in Treatment of Bell's Palsy	Completed	NCT00685789
24	A New Clinical Therapy for Bell's Palsy	Completed	NCT01686464		prednisone and valacyclovir treatments
25	Studying of Acupuncture for Bell's Palsy According to Different Stages	Completed	NCT00608660
26	Electro Physiological Responses to Kabat Motor Control Re-education on Bell's Palsy: A Randomized Controlled Study	Completed	NCT04894513
27	Effects of Kabat Technique and Neuromuscular Re-Education in Patients With Bell's Palsy	Completed	NCT04807491
28	EFFECTIVENESS OF PULSED ULTRASOUND TREATMENT ON PATIENT WITH BELL'S PALSY, A DOUBLE-BLIND, RANDOMİZED, PLACEBO-CONTROLLED TRIAL	Completed	NCT04412733
29	Effects of Mirror Therapy Application of Tablet pc on Acute Bell's Palsy.	Completed	NCT04936152
30	Ultrasound-Guided Stellate Ganglion Block With Botulinum Toxin Versus Steroid in Refractory Bell's Palsy	Completed	NCT05099835		Botox;triamcinolonacetonide
31	Stellate Gnaglion Block Versus Conventional Therapey in Refractory Bell's Palsy; A Rondomized Single Blind Clinical Trial	Completed	NCT05094245
32	Effect of Neural Mobilization in Bells Palsy: A Randomized Controlled Trial	Completed	NCT04280120
33	Effect of Laser Acupuncture Treatment on Chronic Facial Paralysis: A Randomized Sham Control, Double Blind Pilot Study	Completed	NCT03592797
34	Function and Form Outcomes in Patients With Facial Paralysis	Completed	NCT03974763
35	The Role of Collagen in the Rehabilitation of Peripheral Paralysis of the Facial Nerve	Completed	NCT04353908
36	Photobiomodulation Therapy for Facial Paralysis Over 8 Weeks: An Open-Label Pilot, Non-concurrent Control Study	Completed	NCT05585333
37	Non-surgical Correction of Eye Lid Paralysis With External Magnet Systems	Completed	NCT02988856
38	Lengthening Temporalis Myoplasty and Improvement of Primary Swallowing Disorders in Facial Paralysis	Completed	NCT03284125
39	Assessment of the Cross-face Nerve Graft in the Treatment of Facial Paralysis	Completed	NCT03006783
40	Improvement of Facial Symmetry With Myofunctional Therapy Combined to Botulinum Toxin Injections in Long Standing Facial Paralysis	Completed	NCT00989209		Botulinum Toxin Type A
41	Antiviral Treatment in Facial Palsy. Randomized Control Trial	Completed	NCT02328079		Steroids (Prednisolone) and Steroids plus Antiviral (Prednisolone + acyclovir)
42	Production et Perception émotionnelle Chez Les Patients paralysés Faciaux: Marqueurs Respiratoires, Phonatoires et expressivité Faciale.	Completed	NCT03619720
43	Post-parotidectomy Facial Paresis: Intraoperative and Postoperative Factors	Completed	NCT02527226
44	The Role of MyotonPro in Assessing the Biomechanical Properties of Facial Muscles in Facial Paralysis Patients and Its Role in Monitoring Recovery Following Facial Reanimation Surgery	Completed	NCT02489162
45	Anthropometric Angular Measurement to Determine Muscle Tonus in Patients With Peripheral Facial Paralysis	Completed	NCT00903669
46	Treatment Bell´s Palsy: Prednisone vs Prednisone Valacyclovir	Completed	NCT00561106		prednisone- valacyclovir;prednisone-placebo
47	Effect of Stellate Ganglion Block Combined With Facial Nerve Block on the Treatment of Idiopathic Facial Paralysis	Completed	NCT04800666		Mecobalamin Tablets
48	A Pilot Study Evaluating the Effectiveness of Information and Therapy Guides for Improving the Psychosocial Wellbeing of People With Facial Palsy.	Completed	NCT03943953
49	Comparison of Motor Imagery Technique and Mime Therapy on Facial Expressions in Facial Palsy Patients; A Randomized Clinical Trial	Completed	NCT04993417
50	Pilot Study Assessing Cognitive Function and Emotional Possessing in Patients With Bilateral Facial Palsy	Completed	NCT02179450

Search NIH Clinical Center for Bell's Palsy

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

Scopolamine

Scopolamine Hydrobromide

Cochrane evidence based reviews: bell palsy

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Genetic Tests for Bell's Palsy

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Anatomical Context for Bell's Palsy

Organs/tissues related to Bell's Palsy:

MalaCards : Eye, Bone, Salivary Gland, Skin, Brain, Skeletal Muscle, Tongue

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Publications for Bell's Palsy

Articles related to Bell's Palsy:

(show top 50) (show all 13997)

#	Title	Authors	PMID	Year
1	Clinical use of thread embedding acupuncture for facial nerve palsy: A web-based survey. ⁶² ⁴¹	Kang D...Nam SS	36451397	2022
2	Bell's palsy misdiagnosis: characteristics of occult tumors causing facial paralysis. ⁶² ⁴¹	Chung EJ...Yoo J	36258246	2022
3	Bell's Palsy: Etiology, Management and Dental Implications. ⁶² ⁴¹	Danesh A...Ouanounou A	36322635	2022
4	Posterior reversible encephalopathy syndrome (PRES): Should more attention be paid to the atypical forms? ⁶²	Andour H...Touarsa F	36457790	2023
5	Sural Nerve Vertical Cross-Face Graft for Lacrimal Gland Neurotization to Improve Tear Secretion in Neurodeprivative Dry Eye. ⁶²	Giannaccare G...Biglioli F	36459583	2023
6	Association Between Clinical Symptoms, Electrodiagnostic Findings, Clinical Outcome, and Prodromal Symptoms in Patients With Bell's Palsy. ⁶²	Chae SA...Chon J	35109694	2023
7	Epidemiology, clinical features, and treatment modalities of facial nerve palsy in COVID-19 patients: a systematic review. ⁶²	Turki A...Huy NT	35917018	2022
8	Bilateral facial palsy as the first sign of HIV infection. ⁶²	Giammello F...Girlanda P	35945381	2022
9	Therapists' perceptions and attitudes in facial palsy rehabilitation therapy: A mixed methods study. ⁶²	van Veen MM...Dijkstra PU	33890851	2022
10	Effectiveness of multiwave locked system laser on the treatment of patients with idiopathic Bell's palsy: a randomized double-blind placebo controlled trial. ⁶²	Alayat MS...Fiky AARE	35881208	2022
11	Ruptured bilateral middle cerebral artery aneurysms diagnosed based on cerebral vasospasm-associated ischemic symptoms: A case report. ⁶²	Yoshida Y...Iwadate Y	36176966	2022
12	A case of head and neck cutaneous squamous cell carcinoma highlighting aggressive perineural features. ⁶²	Kalil GH...Jefferson GD	36189160	2022
13	Nocardia Farcinica Mastoiditis and Epidural Abscess in an Immunocompetent Patient: A Rare Entity. ⁶²	Gkrinia E...Kivekas I	36453208	2022
14	Surgical management of tympanojugular paragangliomas using the flexible CO2 laser. ⁶²	Hackenberg S...Scherzad A	35511294	2022
15	Trends and Outcomes of Fungal Temporal Bone Osteomyelitis: A Scoping Review. ⁶²	Macias D...Rizk HG	36351221	2022
16	Cholesteatoma With Cochlear Fistula and Carotid Dehiscence. ⁶²	Nasrollahi T...Djalilian HR	36045486	2022
17	Enhancement of cranial nerves in Lyme neuroborreliosis: incidence and correlation with clinical symptoms and prognosis. ⁶²	Lindland ES...Beyer MK	35608630	2022
18	Long-term results of upfront, single-session Gamma Knife radiosurgery for large cystic vestibular schwannomas. ⁶²	Peker S...Temel Y	36471101	2022
19	Asymmetric crying facies in an elderly, when a facial asymmetry is not a facial paralysis but a marker of possible congenital malformations: case report and review of the literature. ⁶²	Thomas Q...Giroud M	36456879	2022
20	Objective assessment of eyelid position and tear meniscus in facial nerve palsy. ⁶²	Galindo-Ferreiro A...Schellini SA	34958290	2022
21	A post-marketing safety assessment of COVID-19 mRNA vaccination for serious adverse outcomes using administrative claims data linked with vaccination registry in a city of Japan. ⁶²	Takeuchi Y...Yasunaga H	36371366	2022
22	ELN missense variant in patient with mid-aortic syndrome case report. ⁶²	Phan TN...Nguyen TT	36460951	2022
23	Physical rehabilitation of central facial palsy: A survey of current multidisciplinary practice. ⁶²	Vaughan A...Miles A	34928754	2022
24	Selective Neurectomy for Treatment of Post-Facial Paralysis Synkinesis: A Systematic Review. ⁶²	Shikara M...Justicz N	36155895	2022
25	Incidence and Management of Facial Paralysis After Skull Base Trauma, an Administrative Database Study. ⁶²	Wamkpah NS...Durakovic N	36214506	2022
26	Therapeutic strategy for facial paralysis based on the combined application of Si-based agent and methylcobalamin. ⁶²	Koyama Y...Shimada S	36438600	2022
27	Effect of the acupuncture within 24 hour after the onset of peripheral facial paralysis. ⁶²	Song GM...Mou KJ	35850903	2022
28	Ectopic thymic carcinoma of the parotid gland. ⁶²	Cheng J...Zheng N	35339333	2022
29	Is There a Role for Cerebral Ultrasonography in Near-Term/Term Neonates Following Assisted Vaginal Delivery? A Prospective, Single-Center Study. ⁶²	Poryo M...Tutdibi E	32911558	2022
30	Axonal Regeneration Through Autologous Grafts: Does the Axonal Load Influence Regeneration? ⁶²	Leckenby JI...Grobbelaar AO	36037615	2022
31	Coronavirus-associated mucormycosis: different from sinonasal mucormycosis. ⁶²	Kataria T...Agarwal S	35791976	2022
32	Comparative analysis of benign and malignant parotid gland tumors: A retrospective study of 992 patients. ⁶²	Lee DH...Lim SC	36473266	2022
33	Superficial versus total parotidectomy for recurrent pleomorphic adenoma in the parotid gland. ⁶²	Roh JL	36067593	2022
34	Predicting Depressor Anguli Oris Excision Outcomes Using Local Muscle Block. ⁶²	O'Rourke SP...Miller MQ	36378249	2022
35	Does preoperative gamma knife treatment affect the result of microresection of vestibular schwannoma? ⁶²	Huang B...Zhang Y	36316569	2022
36	Maxillofacial Skeleton and Facial Anatomy. ⁶²	Junn JC...Som PM	36244720	2022
37	Hemifacial Spasm Caused by Distal Neurovascular Compression Confirmed by Lateral Spread Response Monitoring. ⁶²	Xu X...Chen Y	36409872	2022
38	Dual-Innervated Free Gracilis Muscle Transfer for Facial Reanimation in Children. ⁶²	Deramo PJ...Nguyen PD	36279580	2022
39	Treatment, Survival, and Demographics in Temporal Bone Malignancies: A Pooled Data Analysis. ⁶²	Gore MR	36452912	2022
40	Aural tuberculosis at the start of the 21st century. Literature review according to SWiM guidelines. Part 2: Treatment. ⁶²	Malinvaud D...Laccourreye O	35778340	2022
41	Delayed Facial Nerve Paralysis After Vestibular Schwannoma Resection. ⁶²	Jia XH...Zhao WD	36379361	2022
42	Totally Endoscopic Transcanal Facial Nerve Decompression in Patients with Traumatic Facial Nerve Paralysis: from Geniculate Ganglion to Mastoid Segment. ⁶²	Daneshi A...Mohebbi S	36382446	2022
43	Thematic Analysis of Canadian Patient-Reported Outcomes in Facial Nerve Paralysis: A Combined Interpretive Description and Modified Delphi Approach. ⁶²	Wihlidal JGJ...Mendez A	35486834	2022
44	Tri-Vector Gracilis Microneurovascular Free Tissue Transfer with Periocular Component to Achieve a Duchenne Smile in Patients with Facial Paralysis. ⁶²	Byrne PJ...Genther DJ	36265011	2022
45	Commentary on: "Tri-Vector Gracilis Microneurovascular Free Tissue Transfer with Periocular Component to Achieve a Duchenne Smile in Patients with Facial Paralysis" by Byrne et al. ⁶²	Davis ME...Greene J	36264588	2022
46	Does SARS-CoV2 vaccine exposure trigger acute-onset polyradiculopathy characterized by more common facial paralysis? ⁶²	Galassi G...Kaleci S	36059144	2022
47	Automatic Analysis of Asymmetry in Facial Paralysis Patients Using Landmark-Based Measures. ⁶²	Bose D...Kochhar A	35271372	2022
48	Pintail Comb Injury as a Rare Cause of Penetrating Temporal Bone Trauma With Facial Paralysis. ⁶²	Cooper DJ...Pelosi S	33172309	2022
49	Analysis of Risk Factors and Prediction Model for Recurrence of Hemifacial Spasm After Radiofrequency Ablation. ⁶²	Fei Y...Yao M	36375197	2022
50	Symptoms and clinical features in patients affected by endolymphatic sac tumor: a systematic review and meta-analysis. ⁶²	Gioacchini FM...Re M	35704074	2022

Sources

Genes for Bell's Palsy

Genes related to Bell's Palsy (0 elite genes):

(show all 18)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MARVELD1	MARVEL Domain Containing 1	Protein Coding	7.34	DISEASES inferred ¹⁴
2	LIPN	Lipase Family Member N	Protein Coding	6.42	DISEASES inferred ¹⁴
3	MTRNR2L5	MT-RNR2 Like 5 (Pseudogene)	Pseudogene	6.4	DISEASES inferred ¹⁴
4	CD4	CD4 Molecule	Protein Coding	5.84	DISEASES inferred ¹⁴
5	MIR4642	MicroRNA 4642	RNA Gene	5.83	DISEASES inferred ¹⁴
6	ACE2	Angiotensin Converting Enzyme 2	Protein Coding	5.68	DISEASES inferred ¹⁴
7	FKBP4	FKBP Prolyl Isomerase 4	Protein Coding	5.52	DISEASES inferred ¹⁴
8	CD8A	CD8a Molecule	Protein Coding	5.44	DISEASES inferred ¹⁴
9	CRP	C-Reactive Protein	Protein Coding	5.4	DISEASES inferred ¹⁴
10	ACE	Angiotensin I Converting Enzyme	Protein Coding	5.21	DISEASES inferred ¹⁴
11	HOXB1	Homeobox B1	Protein Coding	5.18	DISEASES inferred ¹⁴
12	TNF	Tumor Necrosis Factor	Protein Coding	5.15	DISEASES inferred ¹⁴
13	ALB	Albumin	Protein Coding	5.14	DISEASES inferred ¹⁴
14	KANTR	KANTR Integral Membrane Protein	Protein Coding	5.13	DISEASES inferred ¹⁴
15	SERINC4	Serine Incorporator 4	Protein Coding	5.09	DISEASES inferred ¹⁴
16	MBP	Myelin Basic Protein	Protein Coding	5	DISEASES inferred ¹⁴
17	IL6	Interleukin 6	Protein Coding	4.99	DISEASES inferred ¹⁴
18	TLR3	Toll Like Receptor 3	Protein Coding	4.95	DISEASES inferred ¹⁴

Sources

Variations for Bell's Palsy

Sources

Expression for Bell's Palsy

Search GEO for disease gene expression data for Bell's Palsy.

Sources

Pathways for Bell's Palsy

Pathways related to Bell's Palsy according to GeneCards Suite gene sharing:

(show all 14)

#	Super pathways	Score	Top Affiliating Genes
1	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	11.69	TNF IL6 CD8A CD4
2	Th17 Differentiation ⁶⁵ Show member pathways IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	11.67	TLR3 IL6 CD4
3	Innate Lymphoid Cells Differentiation ⁶⁵	11.59	TNF CD8A CD4
4	IL27-mediated signaling events ⁶¹ Show member pathways IL12 signaling pathway ⁶⁷ Th1 Differentiation ⁶⁵	11.56	TNF TLR3 IL6 CD4
5	Acute viral myocarditis ⁷⁴	11.55	TLR3 IL6 CD4
6	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	11.5	TNF IL6 CRP
7	Fibrin complement receptor 3 signaling pathway ⁷⁴	11.24	TNF TLR3 IL6
8	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.13	TNF IL6 CD8A CD4
9	Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway ⁷⁴	11.06	TNF IL6 ACE2
10	Cytokines and inflammatory response ⁷⁴	11.01	CD4 IL6 TNF
11	Network map of SARS-CoV-2 signaling pathway ⁷⁴ Show member pathways Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex ⁷⁴	10.91	IL6 CRP CD8A CD4 ACE2
12	Overview of nanoparticle effects ⁷⁴	10.61	TNF IL6 CRP
13	COVID-19 adverse outcome pathway ⁷⁴	10.52	IL6 ACE2
14	Cells and molecules involved in local acute inflammatory response ⁷⁴ Show member pathways IL8-mediated signaling events ⁶¹	10.16	TNF IL6

Sources

GO Terms for Bell's Palsy

Biological processes related to Bell's Palsy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of chemokine production	GO:0032722	9.85	TNF TLR3 IL6
2	immune response	GO:0006955	9.81	TNF TLR3 MBP IL6 CD8A CD4
3	negative regulation of signaling receptor activity	GO:2000272	9.65	TNF MTRNR2L5 ACE2
4	regulation of systemic arterial blood pressure by renin-angiotensin	GO:0003081	9.62	ACE2 ACE
5	positive regulation of interleukin-6 production	GO:0032755	9.56	TNF TLR3 MBP IL6
6	negative regulation of lipid storage	GO:0010888	9.1	TNF IL6 CRP