MCID: BLL003
MIFTS: 49

Bell's Palsy

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Bell's Palsy

MalaCards integrated aliases for Bell's Palsy:

Name: Bell's Palsy 12 76 53 54 43 15
Bell Palsy 12 53 44 73
Facial Paralysis 53 73
Facial Cranial Nerve Paralysis 53
Idiopathic Facial Palsy 53
Refrigeration Palsy 53
Facial Nerve Palsy 53
Bell's Palsy 12
Antoni's Palsy 53
Facial Palsy 53

Classifications:



External Ids:

Disease Ontology 12 DOID:12506
ICD10 33 G51.0
ICD9CM 35 351.0
MeSH 44 D020330
UMLS 73 C0376175

Summaries for Bell's Palsy

NINDS : 54 Bell's palsy is a form of temporary facial paralysis resulting from damage or trauma to the 7th cranial nerve, one of the facial nerves. It is the most common cause of facial paralysis. Generally, Bell's palsy affects only one side of the face, but it can affect both sides. Symptoms vary among individuals and include sudden weakness on one side of the face, drooping eyelid or corner of the mouth, drooling, inability to close the eye or mouth, altered taste, and excessive tearing in the eye. Symptoms appear suddenly and reach their peak within 72 hours. Bell's palsy can range in severity from mild weakness to total paralysis, and can cause significant facial distortion. The exact cause of Bell's palsy isn't known, but many scientists believe that reactivation of a dormant viral infection can cause the facial nerve to swell and become inflamed. Several other conditions can cause facial paralysis that might be diagnosed as Bell's palsy. The disorder can affect anyone at any age. Risk factors include pregnancy, preeclampsia, obesity, hypertention, diabetes, and upper respiratory ailments.

MalaCards based summary : Bell's Palsy, also known as bell palsy, is related to facial paralysis and essential tremor, and has symptoms including hemiplegia, ophthalmoplegia and oral manifestations. An important gene associated with Bell's Palsy is HS1BP3 (HCLS1 Binding Protein 3). The drugs Methylprednisolone and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and bone.

Disease Ontology : 12 A facial paralysis resulting from dysfunction in the cranial nerve VII (facial nerve).

NIH Rare Diseases : 53 Bell's palsy is a form of temporary facial paralysis which results from damage or trauma to one of the facial nerves. This disorder is characterized by the sudden onset of facial paralysis that often affects just one side and can cause significant facial distortion. Symptoms vary, but may include twitching, weakness, drooping eyelid or corner of the mouth, drooling, dry eye or mouth, impairment of taste, and excessive tearing in the eye. While the exact cause is unknown, many researchers believe that a virus may lead to swelling of the 7th cranial nerve. Steroids, such as prednisone, may reduce the inflammation and swelling. Other medications used to treat Bell's palsy include acyclovir (to fight viral infections) and aspirin, acetaminophen, or ibuprofen (to relieve pain).Physical therapy, facial massage and acupuncture have also been used.

MedlinePlus : 43 Bell's palsy is the most common cause of facial paralysis. It usually affects just one side of the face. Symptoms appear suddenly and are at their worst about 48 hours after they start. They can range from mild to severe and include Twitching Weakness Paralysis Drooping eyelid or corner of mouth Drooling Dry eye or mouth Excessive tearing in the eye Impaired ability to taste Scientists think that a viral infection makes the facial nerve swell or become inflamed. You are most likely to get Bell's palsy if you are pregnant, diabetic or sick with a cold or flu. Three out of four patients improve without treatment. With or without treatment, most people begin to get better within 2 weeks and recover completely within 3 to 6 months. NIH: National Institute of Neurological Disorders and Stroke

Wikipedia : 76 Bell\'s palsy is a type of facial paralysis that results in an inability to control the facial muscles... more...

Related Diseases for Bell's Palsy

Graphical network of the top 20 diseases related to Bell's Palsy:



Diseases related to Bell's Palsy

Symptoms & Phenotypes for Bell's Palsy

UMLS symptoms related to Bell's Palsy:


hemiplegia, ophthalmoplegia, oral manifestations, sciatica, facial paresis, facial palsy, upper motor neuron, facial palsy, lower motor neuron, hemifacial paralysis, back pain, headache, flaccid muscle tone, pain, seizures, syncope, tremor, chronic pain, muscle weakness, vertigo/dizziness, generalized muscle weakness, sleeplessness

Drugs & Therapeutics for Bell's Palsy

Drugs for Bell's Palsy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 79)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Not Applicable 83-43-2 6741
2
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Not Applicable 50-24-8 5755
3
Acyclovir Approved Phase 4,Not Applicable 59277-89-3 2022
4
Acetylcholine Approved Phase 4,Not Applicable 51-84-3 187
5
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
6 Antiemetics Phase 4,Phase 3,Not Applicable
7 Anti-Inflammatory Agents Phase 4,Phase 3,Not Applicable
8 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Not Applicable
9 Autonomic Agents Phase 4,Phase 3,Not Applicable
10 Gastrointestinal Agents Phase 4,Phase 3,Not Applicable
11 glucocorticoids Phase 4,Phase 3,Not Applicable
12 Hormone Antagonists Phase 4,Phase 3,Not Applicable
13 Hormones Phase 4,Phase 3,Not Applicable
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Not Applicable
15 Methylprednisolone acetate Phase 4,Phase 3,Not Applicable
16 Methylprednisolone Hemisuccinate Phase 4,Phase 3,Not Applicable
17 Neuroprotective Agents Phase 4,Phase 3,Not Applicable
18 Peripheral Nervous System Agents Phase 4,Phase 3,Not Applicable
19 Prednisolone acetate Phase 4,Phase 3,Not Applicable
20 Prednisolone hemisuccinate Phase 4,Phase 3,Not Applicable
21 Prednisolone phosphate Phase 4,Phase 3,Not Applicable
22 Protective Agents Phase 4,Phase 3,Not Applicable
23 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable
24 Antiviral Agents Phase 4,Not Applicable
25 valacyclovir Phase 4,Not Applicable
26 abobotulinumtoxinA Phase 4,Not Applicable
27 Botulinum Toxins Phase 4,Not Applicable
28 Botulinum Toxins, Type A Phase 4,Not Applicable
29 Cholinergic Agents Phase 4,Not Applicable
30 incobotulinumtoxinA Phase 4
31 Neuromuscular Agents Phase 4,Not Applicable
32 Neurotransmitter Agents Phase 4,Not Applicable
33 onabotulinumtoxinA Phase 4,Not Applicable
34 Vaccines Phase 4,Phase 3,Phase 2
35 Anesthetics Phase 4,Phase 3,Not Applicable
36 Anesthetics, Local Phase 4,Not Applicable
37 Anti-Arrhythmia Agents Phase 4,Phase 3
38 Central Nervous System Depressants Phase 4,Phase 3,Not Applicable
39 Diuretics, Potassium Sparing Phase 4
40 Sodium Channel Blockers Phase 4
41
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 3 7487-88-9 24083
42
Nicardipine Approved, Investigational Phase 3,Phase 1 55985-32-5 4474
43
Benzocaine Approved, Investigational Phase 3 1994-09-7, 94-09-7 2337
44
Diltiazem Approved, Investigational Phase 3 42399-41-7 39186
45
Labetalol Approved Phase 3 36894-69-6 3869
46 tannic acid Approved, Nutraceutical Phase 3
47 Urapidil Investigational Phase 3 34661-75-1
48 Analgesics Phase 3
49 Anticonvulsants Phase 3
50 calcium channel blockers Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 75)
# Name Status NCT ID Phase Drugs
1 Scandinavian Bell's Palsy Study Completed NCT00510263 Phase 4 Prednisolone + placebo;Valaciclovir + placebo;Prednisolone + valaciclovir;Placebo + placebo
2 Comparison of Three Botulinum Neuromodulators for Management of Facial Synkinesis Completed NCT03048383 Phase 4 OnabotulinumtoxinA Injectable Product;AbobotulinumtoxinA Injectable Product;Incobotulinumtoxin A Injectable Product
3 A Study of Fluzone® High-Dose Vaccine Compared With Fluzone® Vaccine In Elderly Adults Completed NCT01427309 Phase 4
4 Reinnervation of Facial Muscles After Lengthening Temporalis Myoplasty Terminated NCT01833221 Phase 4 injection of 1% lidocaine, 2mL for facial nerve block
5 Corticosteroids in Prevention of Facial Palsy After Cranial Base Surgery Completed NCT00438087 Phase 3 methylprednisolone
6 Additional 6-Month Safety Follow-up After Completion of Precursor Study 880801 Completed NCT01604746 Phase 3
7 Field Administration of Stroke Therapy - Magnesium (FAST-MAG) Trial Completed NCT00059332 Phase 3 Magnesium Sulfate;Normal Saline
8 A Study to Investigate Mepolizumab in the Treatment of Eosinophilic Granulomatosis With Polyangiitis Completed NCT02020889 Phase 3 Placebo
9 Intratympanic Steroid for Bell's Palsy Recruiting NCT03508440 Phase 2, Phase 3 Prednisone
10 Neuroprotectant for Hypertensive Intracerebral Hemorrhage Not yet recruiting NCT03546283 Phase 3 Placebos;Cattle Encephalon Glycoside and Ignotin
11 Multi-Year Study of Fluzone High-Dose Influenza Vaccine Compared With Fluzone® Vaccine in Adults Aged 65 Years and Older Terminated NCT00976027 Phase 3
12 Antihypertensive Treatment of Acute Cerebral Hemorrhage-II Terminated NCT01176565 Phase 3 Intravenous nicardipine hydrochloride
13 Quadrant Versus Superficial Parotidectomy Withdrawn NCT01607866 Phase 2, Phase 3
14 Comparison of Antibiotic Therapy Alone or Combined With Corticosteroids for the Treatment of Nontuberculous Mycobacterial Cervicofacial Lymphadenitis in Children: A Randomized Double-Blind Placebo-Controlled Study Withdrawn NCT01614977 Phase 3 Methylprednisoline
15 Palliative Re-irradiation for Progressive Diffuse Intrinsic Pontine Glioma (DIPG) in Children Completed NCT01777633 Phase 1, Phase 2
16 Seasonal Flu Vaccine in Adult Transplant Recipients Completed NCT01258023 Phase 2
17 Contrastim Stroke Trial Completed NCT01049802 Phase 1, Phase 2
18 A Study of GSK2118436 in BRAF Mutant Metastatic Melanoma Completed NCT01153763 Phase 2 GSK2118436
19 A Study to Evaluate the Efficacy and Safety of TF0023 Spray on Subjects With Ischemic Strokes Recruiting NCT02785120 Phase 2 TF0023
20 Activated Protein C in Acute Stroke Trial Terminated NCT00533546 Phase 2 Activated Protein C
21 Metyrosine (Demser®) for the Treatment of Psychotic Disorders in Patients With Velocardiofacial Syndrome Terminated NCT01127503 Phase 2 Metyrosine;Placebo
22 Antihypertensive Treatment in Acute Cerebral Hemorrhage Completed NCT00415610 Phase 1 nicardipine
23 The Relationship Between Psychological Factors and Bell's Palsy Unknown status NCT01377766
24 Prednisone and Acupuncture for the Treatment of Facial Neuritis: a Multiple Center, CER in China Unknown status NCT01201642 Not Applicable Prednisolone
25 Two Different Surgical Methods of Blepharospasm Unknown status NCT02765113 Early Phase 1
26 Comparing the Behavior of the Cardiac Autonomic Regulation System During 24h in Patient Post Stroke and Controls Unknown status NCT02735616
27 A Clinical Study on the Combined Magnetic and Oxygen Treatment for Bell's Palsy Completed NCT01686464 Not Applicable prednisone and valacyclovir treatments
28 Randomized Controlled Trial of Acupuncture to Treat Bell's Palsy According to Different Stages Completed NCT00608660 Not Applicable
29 Acupuncture With Deqi And Psychological Effects in Treatment of Bell's Palsy Completed NCT00685789 Not Applicable
30 Prednisone-Placebo vs Prednisone-Valacyclovir in Bell´s Palsy Completed NCT00561106 Not Applicable prednisone- valacyclovir;prednisone-placebo
31 Steroid-Antiviral Treatment in Rehabilitation of Facial Palsy Completed NCT02328079 Not Applicable Steroids (Prednisolone) and Steroids plus Antiviral (Prednisolone + acyclovir)
32 Microbiologic Findings of Acute Facial Palsy in Children Completed NCT01537952
33 Anthropometric Angular Measurement to Determine Muscle Tonus in Patients With Peripheral Facial Paralysis Completed NCT00903669
34 Assessment of the Cross-face Nerve Graft in the Treatment of Facial Paralysis Completed NCT03006783
35 Myofunctional Therapy in Facial Palsy Completed NCT00989209 Not Applicable Botulinum Toxin Type A
36 Cognitive Function and Emotional Possessing in Bilateral Facial Palsy Completed NCT02179450
37 Study of a New Technique to Improve the Symptoms of Orofacial Discomfort in Patients With Peripheral Facial Paralysis Completed NCT01327157 Not Applicable
38 Complications in Parotid Surgery Completed NCT02486393
39 Retrospective Clinical Outcome of Parotid Tumor Surgery Completed NCT01983176
40 Post-parotidectomy Facial Paresis: Intraoperative and Postoperative Factors Completed NCT02527226 Not Applicable
41 Postmarketing Safety Study of Q/LAIV in Subjects 2 Through 49 Years of Age Completed NCT01985997
42 Clinical Research Core Dental Screening Protocol Completed NCT00090818
43 Post-authorisation Passive Enhanced Safety Surveillance of Seasonal Influenza Vaccines Completed NCT02893878
44 National Prospective and Comparative Study on the Mode of Delivery of Twins Completed NCT01987063
45 Acute Recanalization of Thrombo-Embolic Ischemic Stroke With pREset (ARTESp) Completed NCT02437409
46 Descriptive, Post-marketing, Passive Surveillance Safety Study of ADACEL™ Vaccine Completed NCT00258882
47 Anterior Ultrasound-guided Cervical Plexus Block for Carotid Endarterectomy Completed NCT01640613
48 REACT AGAINST STROKE Completed NCT02846363
49 Ultrasound Evaluation of Tongue Movements in Speech and Swallowing Completed NCT00001167
50 Neuronal and Glial Biomarkers in Stroke Completed NCT02409043

Search NIH Clinical Center for Bell's Palsy

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: bell palsy

Genetic Tests for Bell's Palsy

Anatomical Context for Bell's Palsy

MalaCards organs/tissues related to Bell's Palsy:

41
Eye, Testes, Bone, Skin, Tongue, Neutrophil, Brain

Publications for Bell's Palsy

Articles related to Bell's Palsy:

(show top 50) (show all 643)
# Title Authors Year
1
The effect of metabolic syndrome on Bell's palsy recovery rate. ( 29374993 )
2018
2
Prognostic role of neurophysiological testing 3-7 days after onset of acute unilateral Bell's palsy. ( 29496378 )
2018
3
Prognostic value of the blink reflex test in Bell's palsy and Ramsay-Hunt syndrome. ( 29402606 )
2018
4
A Case of An Unusual Bell's Palsy Mimic. ( 29961527 )
2018
5
Pontine haemorrhage disguised as Bell's palsy. ( 29437741 )
2018
6
Augmentation effect of acupuncture on Bi'nao for hypophasis in patients with Bell's palsy: study protocol for a randomized controlled trial. ( 29891003 )
2018
7
Delayed facial nerve decompression for severe refractory cases of Bell's palsy: a 25-year experience. ( 29301560 )
2018
8
A Case of Bell's Palsy Complicated by Subsequent Herpes Simplex Virus Encephalitis. ( 29144221 )
2018
9
Prevalence and characteristics of hearing loss in patients diagnosed with Bell's Palsy. ( 29164322 )
2018
10
Idiopathic Non-traumatic Facial Nerve Palsy (Bell's Palsy) in Neonates; An Atypical Age and Management Dilemma. ( 29468002 )
2018
11
A Case Report of a Child with Bell's Palsy. ( 29872589 )
2018
12
Usefulness of High-Resolution 3D Multi-Sequences for Peripheral Facial Palsy: Differentiation Between Bell's Palsy and Ramsay Hunt Syndrome. ( 29135869 )
2017
13
Does Type 2 Diabetes Mellitus Affect the Healing of Bell's Palsy in Adults? ( 29284561 )
2017
14
Recurrent Bell's palsy following ventriculoperitoneal shunt insertion: an unusual case to face. ( 29191062 )
2017
15
Increased risk of peripheral arterial occlusive disease in patients with Bell's palsy using population data. ( 29216223 )
2017
16
Bell's Palsy in Children (BellPIC): protocol for a multicentre, placebo-controlled randomized trial. ( 28193257 )
2017
17
Bell's palsy in children: Current treatment patterns in Australia and New Zealand. A PREDICT study. ( 28177168 )
2017
18
Disrupted functional connectivity of striatal sub-regions in Bell's palsy patients. ( 28180070 )
2017
19
Oxidative Stress and Antioxidant Status in Patients with Bell's Palsy. ( 28680345 )
2017
20
Facial nerve palsy in a child: Bell's palsy? Think again! ( 29527278 )
2017
21
Concurrent pityriasis rosea and Bell's palsy. ( 28115404 )
2017
22
Bidirectional association between Bell's palsy and anxiety disorders: A nationwide population-based retrospective cohort study. ( 28359982 )
2017
23
High Incidence of Bell's Palsy After Mastoidectomy: A Longitudinal Follow-up Study. ( 29065089 )
2017
24
Proposal of a Video-recording System for the Assessment of Bell's Palsy: Methodology and Preliminary Results. ( 28708795 )
2017
25
PML-IRIS in an HIV-2-infected patient presenting as Bell's palsy. ( 28831749 )
2017
26
Bell's Palsy. ( 28375913 )
2017
27
Progression of Lyme disease to Bell's Palsy despite treatment with doxycycline. ( 28705754 )
2017
28
Acupuncture and Kinesio Taping for the acute management of Bell's palsy: A case report. ( 29154053 )
2017
29
Sensorimotor Cortical Neuroplasticity in the Early Stage of Bell's Palsy. ( 28299208 )
2017
30
Prognostic factors of Bell's palsy and Ramsay Hunt syndrome. ( 28079835 )
2017
31
Role of low-level laser therapy added to facial expression exercises in patients with idiopathic facial (Bell's) palsy. ( 28337563 )
2017
32
Benefits of High-dose Steroida88+a88Hespandera88+a88Mannitol Administration in the Treatment of Bell's Palsy. ( 28068304 )
2017
33
Invasive fungal rhinosinusitis presenting as Bell's palsy in a kidney and liver transplant recipient. ( 28495416 )
2017
34
Effect of Age and Severity of Facial Palsy on Taste Thresholds in Bell's Palsy Patients. ( 28417103 )
2017
35
Lyme disease and Bell's palsy: an epidemiological study of diagnosis and risk in England. ( 28396367 )
2017
36
Bell's palsy: excluding serious illness in urgent and emergency care settings. ( 28403702 )
2017
37
A View of the Therapy for Bell's Palsy Based on Molecular Biological Analyses of Facial Muscles. ( 29283103 )
2017
38
Onset of bell's palsy in late pregnancy and early puerperium is associated with worse long-term outcomes. ( 28349542 )
2017
39
Development of Bell's Palsy After Treatment With Ipilimumab and Nivolumab for Metastatic Melanoma: A Case Report. ( 28926356 )
2017
40
High-dose corticosteroids improve the prognosis of Bell's palsy compared with low-dose corticosteroids: A propensity score analysis. ( 28947095 )
2017
41
Bell's palsy and influenza(H1N1)pdm09 containing vaccines: A self-controlled case series. ( 28467420 )
2017
42
Management of Bell's palsy. ( 28798513 )
2017
43
Bell's Palsy. ( 26611696 )
2016
44
Prevalence of Bell's palsy in Qena Governorate, Egypt. ( 27238882 )
2016
45
Prognostic factors for recovery in Portuguese patients with Bell's palsy. ( 27426639 )
2016
46
Synkinesis in Bell's palsy in a randomised controlled trial. ( 27882653 )
2016
47
Thiol/disulphide homeostasis in Bell's palsy as a novel pathogenetic marker. ( 27383276 )
2016
48
Mandibular Canal Widening and Bell's Palsy: Sequelae of Perineural Invasion in Oral Cancer. ( 28025626 )
2016
49
Steroid/Antiviral for the treatment of Bell's palsy: Double blind randomized clinical trial. ( 27689547 )
2016
50
Ocular vestibular evoked myogenic potential testing for the prognosis of Bell's palsy. ( 27609665 )
2016

Variations for Bell's Palsy

Expression for Bell's Palsy

Search GEO for disease gene expression data for Bell's Palsy.

Pathways for Bell's Palsy

GO Terms for Bell's Palsy

Cellular components related to Bell's Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 azurophil granule lumen GO:0035578 8.62 DEFA1 DEFA3

Biological processes related to Bell's Palsy according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 defense response to Gram-negative bacterium GO:0050829 9.51 DEFA1 DEFA3
2 defense response to virus GO:0051607 9.5 DEFA1 DEFA3 MX1
3 antimicrobial humoral response GO:0019730 9.49 DEFA1 DEFA3
4 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.48 DEFA1 DEFA3
5 killing of cells of other organism GO:0031640 9.46 DEFA1 DEFA3
6 antibacterial humoral response GO:0019731 9.43 DEFA1 DEFA3
7 defense response to fungus GO:0050832 9.4 DEFA1 DEFA3
8 innate immune response in mucosa GO:0002227 9.37 DEFA1 DEFA3
9 intracellular estrogen receptor signaling pathway GO:0030520 9.26 DEFA1 DEFA3
10 mitochondrial fission GO:0000266 9.16 MX1 PRKN
11 defense response GO:0006952 9.13 DEFA1 DEFA3 MX1
12 membrane disruption in other organism GO:0051673 8.62 DEFA1 DEFA3

Sources for Bell's Palsy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
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51 NDF-RT
54 NINDS
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57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
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74 UMLS via Orphanet
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