MCID: BNG014
MIFTS: 26

Benign Breast Adenomyoepithelioma

Categories: Cancer diseases

Aliases & Classifications for Benign Breast Adenomyoepithelioma

MalaCards integrated aliases for Benign Breast Adenomyoepithelioma:

Name: Benign Breast Adenomyoepithelioma 12 15 71
Benign Adenomyoepithelioma of the Breast 12

Classifications:



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Disease Ontology 12 DOID:1641
NCIt 49 C5144
UMLS 71 C1332477

Summaries for Benign Breast Adenomyoepithelioma

Disease Ontology : 12 A breast benign neoplasm that is characterized by dual differentiation into luminal cells and myoepithelial cells.

MalaCards based summary : Benign Breast Adenomyoepithelioma, also known as benign adenomyoepithelioma of the breast, is related to breast adenomyoepithelioma and rare tumor. An important gene associated with Benign Breast Adenomyoepithelioma is SFN (Stratifin), and among its related pathways/superpathways are Developmental Biology and Relaxin signaling pathway. Affiliated tissues include breast, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Benign Breast Adenomyoepithelioma

Diseases in the Breast Adenomyoepithelioma family:

Benign Breast Adenomyoepithelioma

Diseases related to Benign Breast Adenomyoepithelioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 220)
# Related Disease Score Top Affiliating Genes
1 breast adenomyoepithelioma 10.3 KRT5 KRT14
2 rare tumor 10.3
3 limbal stem cell deficiency 10.2 SFN KRT14
4 breast myoepithelial neoplasm 10.2 KRT5 KRT14
5 epidermolysis bullosa simplex, autosomal recessive 1 10.2 KRT5 KRT14
6 micronodular basal cell carcinoma 10.2 KRT5 KRT14
7 breast myoepithelial carcinoma 10.2 KRT5 KRT14
8 ureter squamous cell carcinoma 10.2 KRT7 KRT5
9 inverted transitional papilloma 10.2 KRT7 KRT5
10 ureter adenocarcinoma 10.2 KRT7 KRT5
11 epidermolysis bullosa simplex, localized 10.2 KRT5 KRT14
12 ceruminoma 10.2 KRT7 KRT5
13 malignant acrospiroma 10.2 KRT7 KRT5
14 microinvasive cervical squamous cell carcinoma 10.2 KRT7 KRT5
15 cutaneous mucoepidermoid carcinoma 10.2 KRT7 KRT5
16 auditory system benign neoplasm 10.2 KRT7 KRT5
17 eccrine adenocarcinoma 10.2 KRT7 KRT5
18 external ear carcinoma 10.2 KRT7 KRT5
19 vulvar apocrine adenocarcinoma 10.2 KRT7 KRT5
20 middle ear adenoma 10.2 KRT7 KRT5
21 lung clear cell carcinoma 10.2 KRT7 KRT5
22 gastric squamous cell carcinoma 10.2 KRT7 KRT5
23 necrotizing sialometaplasia 10.2 KRT7 KRT5
24 sensory organ benign neoplasm 10.2 KRT7 KRT5
25 bile duct mucoepidermoid carcinoma 10.2 KRT7 KRT5
26 breast mucinous carcinoma 10.2 KRT7 KRT5
27 clear cell hidradenoma 10.2 KRT7 KRT5
28 hidradenoma 10.2 KRT7 KRT5
29 reticulate acropigmentation of kitamura 10.2 KRT5 KRT14
30 middle ear adenocarcinoma 10.2 KRT7 KRT5
31 epidermolysis bullosa simplex, generalized 10.2 KRT5 KRT14
32 malignant biphasic mesothelioma 10.2 KRT7 KRT5
33 benign mesothelioma 10.2 KRT7 KRT5
34 pericardium cancer 10.2 KRT7 KRT5
35 eccrine sweat gland cancer 10.2 KRT7 KRT5
36 balloon cell malignant melanoma 10.2 KRT7 KRT5
37 nephrogenic adenoma of the urethra 10.2 KRT7 KRT5
38 cystadenofibroma 10.2 KRT7 KRT5
39 liver leiomyosarcoma 10.2 KRT7 KRT5
40 solid adenocarcinoma with mucin production 10.2 KRT7 KRT5
41 thymus clear cell carcinoma 10.2 KRT7 KRT5
42 fibroma 10.2 KRT7 KRT14
43 eccrine porocarcinoma 10.1 KRT7 KRT5
44 nasal cavity olfactory neuroblastoma 10.1 KRT7 KRT5
45 esophageal basaloid squamous cell carcinoma 10.1 KRT14 EGFR
46 epidermolysis bullosa simplex with mottled pigmentation 10.1 KRT5 KRT14
47 mucinous stomach adenocarcinoma 10.1 KRT7 KRT5
48 epididymis adenocarcinoma 10.1 KRT7 KRT5
49 epididymis cancer 10.1 KRT7 KRT5
50 middle ear carcinoma 10.1 KRT7 KRT5

Graphical network of the top 20 diseases related to Benign Breast Adenomyoepithelioma:



Diseases related to Benign Breast Adenomyoepithelioma

Symptoms & Phenotypes for Benign Breast Adenomyoepithelioma

GenomeRNAi Phenotypes related to Benign Breast Adenomyoepithelioma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.1 KRT5
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-182 9.1 KRT5
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-6 9.1 KRT8
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.1 KRT5 KRT7 KRT8

MGI Mouse Phenotypes related to Benign Breast Adenomyoepithelioma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.73 EGFR ESR1 KRT14 KRT5 KRT8 SFN
2 hearing/vestibular/ear MP:0005377 9.46 EGFR KRT14 KRT8 SFN
3 integument MP:0010771 9.35 EGFR ESR1 KRT14 KRT5 SFN
4 neoplasm MP:0002006 8.92 EGFR ESR1 KRT14 SFN

Drugs & Therapeutics for Benign Breast Adenomyoepithelioma

Search Clinical Trials , NIH Clinical Center for Benign Breast Adenomyoepithelioma

Genetic Tests for Benign Breast Adenomyoepithelioma

Anatomical Context for Benign Breast Adenomyoepithelioma

MalaCards organs/tissues related to Benign Breast Adenomyoepithelioma:

40
Breast

Publications for Benign Breast Adenomyoepithelioma

Articles related to Benign Breast Adenomyoepithelioma:

# Title Authors PMID Year
1
Benign Bilateral Adenomyoepithelioma of the Mammary Gland in a Ring-tailed Lemur (Lemur catta). 61
28942309 2017
2
Imaging features of benign adenomyoepithelioma of the breast. 61
23325754 2013
3
Ultrasonographic features of benign adenomyoepithelioma of the breast. 61
20808695 2010
4
Fine-needle aspiration biopsy of benign adenomyoepithelioma of the breast: radiologic and pathologic correlation in four cases. 61
17924402 2007
5
Benign adenomyoepithelioma of the breast: imaging findings mimicking malignancy and histopathological features. 61
17325921 2007
6
Benign adenomyoepithelioma of the breast: a case with gross mimicking of malignancy. 61
12390363 2002
7
Benign adenomyoepithelioma of the breast. 61
2544054 1989

Variations for Benign Breast Adenomyoepithelioma

Expression for Benign Breast Adenomyoepithelioma

Search GEO for disease gene expression data for Benign Breast Adenomyoepithelioma.

Pathways for Benign Breast Adenomyoepithelioma

Pathways related to Benign Breast Adenomyoepithelioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.87 KRT8 KRT7 KRT5 KRT14 EGFR
2
Show member pathways
12.25 KRT14 ESR1 EGFR
3 12.1 KRT8 KRT7 KRT5
4
Show member pathways
11.71 KRT8 KRT7 KRT5 KRT14
5 11.25 SFN KRT5 KRT14
6 11.14 ESR1 EGFR
7 11.03 SFN ESR1
8
Show member pathways
10.96 KRT8 KRT7 KRT5 KRT14
9 10.91 KRT8 ESR1
10 10.81 SFN EGFR

GO Terms for Benign Breast Adenomyoepithelioma

Cellular components related to Benign Breast Adenomyoepithelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.87 SFN KRT8 KRT7 KRT5 KRT14 ESR1
2 nucleus GO:0005634 9.7 SFN KRT8 KRT7 KRT5 KRT14 ESR1
3 extracellular exosome GO:0070062 9.65 SFN KRT8 KRT7 KRT5 KRT14
4 intermediate filament GO:0005882 9.26 KRT8 KRT7 KRT5 KRT14
5 keratin filament GO:0045095 8.92 KRT8 KRT7 KRT5 KRT14

Biological processes related to Benign Breast Adenomyoepithelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of fibroblast proliferation GO:0048146 9.37 ESR1 EGFR
2 epidermis development GO:0008544 9.33 KRT5 KRT14 EGFR
3 cellular response to estradiol stimulus GO:0071392 9.32 ESR1 EGFR
4 hemidesmosome assembly GO:0031581 9.26 KRT5 KRT14
5 cornification GO:0070268 9.26 KRT8 KRT7 KRT5 KRT14
6 keratinization GO:0031424 9.02 SFN KRT8 KRT7 KRT5 KRT14

Molecular functions related to Benign Breast Adenomyoepithelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 scaffold protein binding GO:0097110 8.96 KRT8 KRT5
2 nitric-oxide synthase regulator activity GO:0030235 8.62 ESR1 EGFR

Sources for Benign Breast Adenomyoepithelioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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