MCID: BNG014
MIFTS: 30

Benign Breast Adenomyoepithelioma

Categories: Cancer diseases

Aliases & Classifications for Benign Breast Adenomyoepithelioma

MalaCards integrated aliases for Benign Breast Adenomyoepithelioma:

Name: Benign Breast Adenomyoepithelioma 12 15 73
Benign Adenomyoepithelioma of the Breast 12

Classifications:



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Disease Ontology 12 DOID:1641
NCIt 50 C5144
UMLS 73 C1332477

Summaries for Benign Breast Adenomyoepithelioma

Disease Ontology : 12 A breast benign neoplasm that is characterized by dual differentiation into luminal cells and myoepithelial cells.

MalaCards based summary : Benign Breast Adenomyoepithelioma, also known as benign adenomyoepithelioma of the breast, is related to lichen planopilaris and epidermolysis bullosa simplex, autosomal recessive 1. An important gene associated with Benign Breast Adenomyoepithelioma is KRT14 (Keratin 14), and among its related pathways/superpathways are Developmental Biology and Keratinization. Affiliated tissues include lung, skin and kidney, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Benign Breast Adenomyoepithelioma

Diseases in the Breast Adenomyoepithelioma family:

Benign Breast Adenomyoepithelioma

Diseases related to Benign Breast Adenomyoepithelioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 91)
# Related Disease Score Top Affiliating Genes
1 lichen planopilaris 10.1 KRT14 KRT5
2 epidermolysis bullosa simplex, autosomal recessive 1 10.1 KRT14 KRT5
3 epidermolysis bullosa simplex 10.1 KRT14 KRT5
4 epidermolysis bullosa 10.1 KRT14 KRT5
5 epidermolysis bullosa simplex, localized 10.1 KRT14 KRT5
6 epidermolysis bullosa simplex, generalized 10.1 KRT14 KRT5
7 epidermolysis bullosa simplex with mottled pigmentation 10.1 KRT14 KRT5
8 cervical clear cell adenocarcinoma 10.1 KRT14 KRT5
9 odontoma 10.1 KRT14 KRT5
10 vesiculobullous skin disease 10.1 KRT14 KRT5
11 limbal stem cell deficiency 10.1 KRT14 SFN
12 breast benign neoplasm 10.1 KRT14 KRT5
13 thoracic benign neoplasm 10.1 KRT14 KRT5
14 epidermolysis bullosa simplex, dowling-meara type 10.1 KRT14 KRT5
15 spiradenoma 10.1 KRT14 KRT7
16 brooke-spiegler syndrome 10.1 KRT14 KRT7
17 inverted transitional papilloma 10.0 KRT5 KRT7
18 balloon cell malignant melanoma 10.0 KRT5 KRT7
19 ceruminoma 10.0 KRT5 KRT7
20 malignant spiradenoma 10.0 KRT5 KRT7
21 skin benign neoplasm 10.0 KRT14 KRT5
22 benign mesothelioma 10.0 KRT5 KRT7
23 sensory organ benign neoplasm 10.0 KRT5 KRT7
24 bile duct mucoepidermoid carcinoma 10.0 KRT5 KRT7
25 middle ear adenoma 10.0 KRT5 KRT7
26 epithelial-myoepithelial carcinoma 10.0 KRT14 KRT7
27 malignant biphasic mesothelioma 10.0 KRT5 KRT7
28 prostate squamous cell carcinoma 10.0 KRT5 KRT7
29 peritoneum cancer 10.0 KRT5 KRT7
30 gastric squamous cell carcinoma 10.0 KRT5 KRT7
31 dowling-degos disease 10.0 KRT14 KRT5
32 lymphoepithelioma-like carcinoma 10.0 KRT5 KRT7
33 eccrine sweat gland neoplasm 10.0 KRT5 KRT7
34 cystadenofibroma 10.0 KRT5 KRT7
35 nasal cavity squamous cell carcinoma 10.0 KRT5 KRT7
36 atypical choroid plexus papilloma 10.0 KRT5 KRT7
37 breast secretory carcinoma 10.0 KRT5 KRT7
38 white sponge nevus 1 10.0 KRT14 KRT7
39 necrotizing sialometaplasia 10.0 KRT5 KRT7
40 anus cancer 10.0 KRT5 KRT7
41 cystitis cystica 10.0 KRT5 KRT7
42 craniopharyngioma 10.0 KRT14 KRT7
43 esophageal basaloid squamous cell carcinoma 10.0 EGFR KRT14
44 thymus cancer 10.0 KRT5 KRT7
45 pleomorphic carcinoma 9.9 EGFR KRT7
46 breast carcinoma in situ 9.9 EGFR KRT5
47 cervical adenosquamous carcinoma 9.9 EGFR KRT7
48 horseshoe kidney 9.9 EGFR KRT7
49 large cell neuroendocrine carcinoma 9.9 EGFR KRT7
50 breast adenomyoepithelioma 9.9 KRT14 KRT5 KRT7

Graphical network of the top 20 diseases related to Benign Breast Adenomyoepithelioma:



Diseases related to Benign Breast Adenomyoepithelioma

Symptoms & Phenotypes for Benign Breast Adenomyoepithelioma

GenomeRNAi Phenotypes related to Benign Breast Adenomyoepithelioma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.4 KRT5
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.4 KRT5
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.4 KRT5
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.4 KRT5
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-58 9.4 EGFR
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.4 KRT7
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.4 KRT5 KRT7
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.4 KRT7
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.4 EGFR KRT5 KRT7

MGI Mouse Phenotypes related to Benign Breast Adenomyoepithelioma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.46 EGFR KRT14 KRT5 SFN
2 digestive/alimentary MP:0005381 9.26 EGFR KRT14 KRT5 SFN
3 integument MP:0010771 8.92 EGFR KRT14 KRT5 SFN

Drugs & Therapeutics for Benign Breast Adenomyoepithelioma

Search Clinical Trials , NIH Clinical Center for Benign Breast Adenomyoepithelioma

Genetic Tests for Benign Breast Adenomyoepithelioma

Anatomical Context for Benign Breast Adenomyoepithelioma

MalaCards organs/tissues related to Benign Breast Adenomyoepithelioma:

41
Lung, Skin, Kidney, Prostate, Pancreas, Thymus

Publications for Benign Breast Adenomyoepithelioma

Articles related to Benign Breast Adenomyoepithelioma:

# Title Authors Year
1
Imaging features of benign adenomyoepithelioma of the breast. ( 23325754 )
2013
2
Ultrasonographic features of benign adenomyoepithelioma of the breast. ( 20808695 )
2010
3
Benign adenomyoepithelioma of the breast: imaging findings mimicking malignancy and histopathological features. ( 17325921 )
2007
4
Fine-needle aspiration biopsy of benign adenomyoepithelioma of the breast: radiologic and pathologic correlation in four cases. ( 17924402 )
2007
5
Benign adenomyoepithelioma of the breast: a case with gross mimicking of malignancy. ( 12390363 )
2002
6
Benign adenomyoepithelioma of the breast. ( 2544054 )
1989

Variations for Benign Breast Adenomyoepithelioma

Expression for Benign Breast Adenomyoepithelioma

Search GEO for disease gene expression data for Benign Breast Adenomyoepithelioma.

Pathways for Benign Breast Adenomyoepithelioma

Pathways related to Benign Breast Adenomyoepithelioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.83 EGFR KRT14 KRT5 KRT7
2
Show member pathways
11.79 KRT14 KRT5 KRT7
3 11.52 EGFR SFN
4 11.38 EGFR SFN
5
Show member pathways
11.17 KRT14 KRT5 KRT7
6 10.75 EGFR SFN
7 10.71 KRT14 KRT5 SFN

GO Terms for Benign Breast Adenomyoepithelioma

Cellular components related to Benign Breast Adenomyoepithelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.46 KRT14 KRT5 KRT7 SFN
2 intermediate filament GO:0005882 9.13 KRT14 KRT5 KRT7
3 keratin filament GO:0045095 8.8 KRT14 KRT5 KRT7

Biological processes related to Benign Breast Adenomyoepithelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane organization GO:0061024 9.37 EGFR SFN
2 cornification GO:0070268 9.33 KRT14 KRT5 KRT7
3 positive regulation of cell growth GO:0030307 9.32 EGFR SFN
4 hemidesmosome assembly GO:0031581 9.26 KRT14 KRT5
5 epidermis development GO:0008544 9.13 EGFR KRT14 KRT5
6 keratinization GO:0031424 8.92 KRT14 KRT5 KRT7 SFN

Molecular functions related to Benign Breast Adenomyoepithelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 8.62 KRT14 KRT5

Sources for Benign Breast Adenomyoepithelioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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