MCID: BNG013
MIFTS: 43

Benign Breast Phyllodes Tumor

Categories: Cancer diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Benign Breast Phyllodes Tumor

MalaCards integrated aliases for Benign Breast Phyllodes Tumor:

Name: Benign Breast Phyllodes Tumor 12 15 74
Phyllodes Tumor 45 17 74
Phyllodes Tumor, Benign 12 74
Benign Phyllodes Neoplasm of the Breast 12
Benign Cystosarcoma Phyllodes 12
Benign Phyllodes Neoplasm 12
Cystosarcoma Phyllodes 12
Phyllodes Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1631
MeSH 45 D003557
SNOMED-CT 69 16566002 71232009
ICD10 34 D48.6

Summaries for Benign Breast Phyllodes Tumor

Disease Ontology : 12 A breast benign neoplasm that has_material_basis in epithelial and stromal tissue and derives from periductal stromal cells of the breast.

MalaCards based summary : Benign Breast Phyllodes Tumor, also known as phyllodes tumor, is related to breast fibroadenoma and angiosarcoma. An important gene associated with Benign Breast Phyllodes Tumor is PGR (Progesterone Receptor), and among its related pathways/superpathways are DNA Damage and Hematopoietic cell lineage. The drugs Parathyroid hormone and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include breast, prostate and lung, and related phenotypes are immune system and muscle

Wikipedia : 77 Phyllodes tumors (from Greek: phullon leaf), also cystosarcoma phyllodes, cystosarcoma phylloides and... more...

Related Diseases for Benign Breast Phyllodes Tumor

Diseases in the Benign Breast Phyllodes Tumor family:

Breast Malignant Phyllodes Tumor

Diseases related to Benign Breast Phyllodes Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 146)
# Related Disease Score Top Affiliating Genes
1 breast fibroadenoma 30.5 MKI67 MME PGR
2 angiosarcoma 30.2 KIT VIM
3 fibromatosis 30.0 KIT VIM
4 ductal carcinoma in situ 30.0 MKI67 PGR
5 malignant fibroxanthoma 30.0 MKI67 VIM
6 cribriform carcinoma 29.7 KIT PGR TP63
7 leiomyosarcoma 29.6 KIT PGR VIM
8 breast malignant phyllodes tumor 11.7
9 benign prostate phyllodes tumor 11.3
10 prostate malignant phyllodes tumor 11.2
11 li-fraumeni syndrome 11.2
12 li-fraumeni syndrome 2 11.2
13 sarcoma 10.5
14 osteogenic sarcoma 10.4
15 infant gynecomastia 10.3
16 gynecomastia 10.3
17 adenocarcinoma 10.3
18 liposarcoma 10.3
19 in situ carcinoma 10.3
20 hypoglycemia 10.3
21 breast cancer 10.2
22 breast reconstruction 10.2
23 myxoid leiomyosarcoma 10.2 MME PGR
24 cervical carcinosarcoma 10.2 MME PGR
25 endometrial stromal nodule 10.2 MME PGR
26 spermatocele 10.2 MME PGR
27 breast benign neoplasm 10.2 MME PGR
28 thoracic benign neoplasm 10.2 MME PGR
29 endometrial stromal tumor 10.2 MME PGR
30 pancreatic mucinous cystadenoma 10.2 MME PGR
31 adenoid basal cell carcinoma 10.2 KIT PGR
32 cystadenoma 10.2 MME PGR
33 peritoneal benign neoplasm 10.2 KIT PGR
34 diffuse peritoneal leiomyomatosis 10.2 KIT PGR
35 chondrosarcoma 10.2
36 desmoid tumor 10.2
37 fibrosarcoma 10.2
38 scirrhous adenocarcinoma 10.2
39 histiocytoma 10.2
40 fibrous histiocytoma 10.2
41 paraplegia 10.2
42 breast giant fibroadenoma 10.2
43 soft tissue sarcoma 10.2
44 undifferentiated pleomorphic sarcoma 10.2
45 malignant leydig cell tumor 10.2 KIT MME
46 rete testis adenocarcinoma 10.1 KIT MME
47 adenomyosis 10.1 MME PGR
48 lymphangiomatosis 10.1 PGR VIM
49 rete testis neoplasm 10.1 KIT MME
50 dysgerminoma of ovary 10.1 KIT PGR

Graphical network of the top 20 diseases related to Benign Breast Phyllodes Tumor:



Diseases related to Benign Breast Phyllodes Tumor

Symptoms & Phenotypes for Benign Breast Phyllodes Tumor

MGI Mouse Phenotypes related to Benign Breast Phyllodes Tumor:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.55 KIT MME PGR TP63 VIM
2 muscle MP:0005369 9.26 KIT PGR TP63 VIM
3 no phenotypic analysis MP:0003012 8.92 KIT MKI67 PGR TP63

Drugs & Therapeutics for Benign Breast Phyllodes Tumor

Drugs for Benign Breast Phyllodes Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Parathyroid hormone Approved, Investigational Phase 1 9002-64-6
2
Fluorouracil Approved Phase 1 51-21-8 3385
3
Belinostat Approved, Investigational Phase 1 866323-14-0
4 Androgens Phase 1
5 Antimetabolites Phase 1
6 Immunosuppressive Agents Phase 1
7 Antimetabolites, Antineoplastic Phase 1
8 Immunologic Factors Phase 1
9 Histone Deacetylase Inhibitors Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid Tumors Completed NCT00413322 Phase 1 belinostat;5-Fluorouracil (5-FU)
2 Radiation Therapy After Surgery in Treating Women With Phyllodes Tumor of the Breast Completed NCT00003404 Not Applicable
3 Phyllodes Tumor Partial Breast Radiation Study Recruiting NCT01089374 Not Applicable

Search NIH Clinical Center for Benign Breast Phyllodes Tumor

Cochrane evidence based reviews: phyllodes tumor

Genetic Tests for Benign Breast Phyllodes Tumor

Anatomical Context for Benign Breast Phyllodes Tumor

MalaCards organs/tissues related to Benign Breast Phyllodes Tumor:

42
Breast, Prostate, Lung, Lymph Node, Skin, Pancreas, Bone

Publications for Benign Breast Phyllodes Tumor

Articles related to Benign Breast Phyllodes Tumor:

(show top 50) (show all 431)
# Title Authors Year
1
Cytologic diagnosis of metastatic malignant phyllodes tumor of the breast in pleural effusion. ( 30829462 )
2019
2
Malignant phyllodes tumor of the breast with liposarcomatous differentiation: A case report with imaging findings. ( 30834064 )
2019
3
Malignant Phyllodes Tumor Recurrence in the Pleural Cavity via the Deep Inferior Epigastric Perforator Flap and Internal Mammary Vessel Bundle: A Case Report. ( 30882414 )
2019
4
Phyllodes tumor with a benign heterologous osseous component: A diagnostic challenge. ( 30901115 )
2019
5
Concurrent phyllodes tumor, eccrine carcinoma, and multinodular goiter 20 years after radiotherapy for Hodgkin lymphoma. ( 30564357 )
2018
6
A Hypoglycemia-inducing Giant Borderline Phyllodes Tumor Secreting High-molecular-weight Insulin-Like Growth Factor II: Immunohistochemistry and a Western Blot Analysis. ( 29021486 )
2018
7
Case Report: presentation of pleomorphic liposarcoma arising in a borderline phyllodes tumor. ( 30567077 )
2018
8
Well-differentiated liposarcoma of the breast arising in a background of malignant phyllodes tumor in a pregnant woman: A rare case report and review of literature. ( 30303154 )
2018
9
Distinction between phyllodes tumor and fibroadenoma in breast ultrasound using deep learning image analysis. ( 30258856 )
2018
10
Increased CD105 expression is associated with disease progression in phyllodes tumors - A report of a borderline phyllodes tumor with lung metastases and a study of 54 phyllodes tumors. ( 29414396 )
2018
11
Association of clinicopathological features and prognosis of TERT alterations in phyllodes tumor of breast. ( 29497099 )
2018
12
Phyllodes Tumor of the Prostate With Epithelial Intestinal Metaplasia. ( 29543676 )
2018
13
Pediatric phyllodes tumors: A review of the National Cancer Data Base and adherence to NCCN guidelines for phyllodes tumor treatment. ( 29605260 )
2018
14
Malignant transformation of phyllodes tumor: a case report and review of literature. ( 29636939 )
2018
15
A huge benign cystic phyllodes tumor presenting as a complex cystic mass on ultrasound examination. ( 30033689 )
2018
16
Huge Fungating Benign Phyllodes Tumor of Breast. ( 30034456 )
2018
17
A huge phyllodes tumor in the breast: a case report. ( 30034663 )
2018
18
Malignant Phyllodes Tumor of the Breast with Metastasis to the Pancreas: A Case Report and Review of Literature. ( 30050709 )
2018
19
Radiopathological characteristics and outcomes of phyllodes tumor of the breast in Malaysian women. ( 30075507 )
2018
20
Malignant Phyllodes tumor in a young female: A Case Report. ( 30145554 )
2018
21
Effect of postoperative time for adjuvant radiotherapy in malignant phyllodes tumor: An institutional experience. ( 30197347 )
2018
22
Malignant phyllodes tumor metastatic to bilateral ovaries: A Krukenberg-like presentation. ( 30197364 )
2018
23
Percutaneous removal of benign phyllodes tumor of the breast: An alternative to surgery. ( 30251456 )
2018
24
Invasive lobular carcinoma involving a borderline phyllodes tumor. ( 30350383 )
2018
25
Malignant phyllodes tumor with metastases to lung, adrenal and brain: A rare case report. ( 30455875 )
2018
26
Phyllodes tumor of the breast with nipple discharge: A case report. ( 30593154 )
2018
27
Coexistence of Ductal Carcinoma Within Mammary Phyllodes Tumor: A Review of 557 Cases From a 20-year Region-wide Database in Hong Kong and Southern China. ( 28689011 )
2018
28
Focal Anomalous Expression of Cytokeratin and p63 in Malignant Phyllodes Tumor: A Comparison With Spindle Cell Metaplastic Carcinoma. ( 28968268 )
2018
29
Metastatic giant malignant phyllodes tumor of the breast. ( 29139587 )
2018
30
A Case of Benign Phyllodes Tumor in a Transgender Woman Receiving Cross-Sex Hormones. ( 29169272 )
2018
31
Early stage malignant phyllodes tumor case report. ( 29247967 )
2018
32
Case Report: Metastatic Phyllodes Tumor. ( 29317034 )
2018
33
Phyllodes Tumor of the Breast: Ultrasound-Pathology Correlation. ( 29412020 )
2018
34
[Breast osteosarcoma originating in a phyllodes tumor. Report of one case]. ( 29189868 )
2017
35
Molecular alterations in lesions of anogenital mammary-like glands and their mammary counterparts including hidradenoma papilliferum, intraductal papilloma, fibroadenoma and phyllodes tumor. ( 28648934 )
2017
36
Benign Phyllodes Tumor With Cystic Squamous Metaplasia: A Cytohistological Correlation of a Rare Case. ( 29531557 )
2017
37
A Rare Case of Phyllodes Tumor Metastasis to the Stomach Presenting as Anemia. ( 27586673 )
2017
38
Metastasis of Mammary Gland Malignant Phyllodes Tumor to the Mandibular Region: A Case Report and Review of the Literature. ( 27765548 )
2017
39
Radiation therapy for malignant phyllodes tumor of the breast: An analysis of SEER data. ( 28013032 )
2017
40
Multiple metastatic malignant phyllodes tumor of the breast with tonsillar metastasis: a case report. ( 28103951 )
2017
41
The Reconstruction Choice for Giant Phyllodes Tumor of Breast: Bi-pedicled Deep Inferior Epigastric Perforator Flap. ( 28130560 )
2017
42
Fulminant course in a case of malignant phyllodes tumor. ( 28203559 )
2017
43
Phyllodes Tumor in the Vulva. ( 28224691 )
2017
44
Phyllodes Tumor With Heterologous Liposarcomatous Differentiation. ( 28381138 )
2017
45
A giant phyllodes tumor of the breast causing severe disfigurement. A case report. ( 28406095 )
2017
46
Giant phyllodes tumor of the breast with diffuse myxoid changes in an adolescent girl: a case report. ( 28458828 )
2017
47
Synchronous Malignant Phyllodes Tumor with Skin Ulceration and Invasive Carcinoma as Collision Tumor. ( 28469344 )
2017
48
Invasive Ductal Carcinoma within a Benign Phyllodes Tumor. ( 28724885 )
2017
49
A rare presentation of malignant phyllodes tumor with bloody nipple discharge-report of a case. ( 28861384 )
2017
50
Mammary phyllodes tumor with six episodes of a relapse: a case report. ( 28911335 )
2017

Variations for Benign Breast Phyllodes Tumor

Copy number variations for Benign Breast Phyllodes Tumor from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 16441 1 124300000 247249719 Gain Phyllodes tumor
2 38178 10 1 40300000 Loss Phyllodes tumor
3 69804 12 56300000 66000000 Amplification MDM2 Phyllodes tumor
4 77646 13 46200000 48900000 Loss RB1 Phyllodes tumor
5 191456 5 1 180857866 Gain Phyllodes tumor
6 214475 6 60500000 170899992 Loss Phyllodes tumor
7 233913 8 128816946 128822855 Amplification MYC Phyllodes tumor

Expression for Benign Breast Phyllodes Tumor

Search GEO for disease gene expression data for Benign Breast Phyllodes Tumor.

Pathways for Benign Breast Phyllodes Tumor

Pathways related to Benign Breast Phyllodes Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.6 MKI67 TP63 VIM
2 11.31 KIT MME
3 11.13 KIT MME
4 10.88 KIT MME
5 10.67 MKI67 MME VIM

GO Terms for Benign Breast Phyllodes Tumor

Biological processes related to Benign Breast Phyllodes Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of Notch signaling pathway GO:0045747 8.62 KIT TP63

Sources for Benign Breast Phyllodes Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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