MCID: BNG013
MIFTS: 36

Benign Breast Phyllodes Tumor

Categories: Cancer diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Benign Breast Phyllodes Tumor

MalaCards integrated aliases for Benign Breast Phyllodes Tumor:

Name: Benign Breast Phyllodes Tumor 12 15 71
Phyllodes Tumor 43 17 71
Benign Phyllodes Neoplasm of the Breast 12
Benign Cystosarcoma Phyllodes 12
Benign Phyllodes Neoplasm 12
Phyllodes Tumor, Benign 71
Cystosarcoma Phyllodes 12
Phyllodes Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1631
MeSH 43 D003557
SNOMED-CT 67 16566002 720344007
ICD10 32 D48.6
UMLS 71 C0010701 C0334501 C1332533

Summaries for Benign Breast Phyllodes Tumor

Disease Ontology : 12 A breast benign neoplasm that has material basis in epithelial and stromal tissue and derives from periductal stromal cells of the breast.

MalaCards based summary : Benign Breast Phyllodes Tumor, also known as phyllodes tumor, is related to breast malignant phyllodes tumor and pleomorphic liposarcoma. An important gene associated with Benign Breast Phyllodes Tumor is PGR (Progesterone Receptor), and among its related pathways/superpathways is Primary Focal Segmental Glomerulosclerosis FSGS. The drugs Fluorouracil and Parathyroid hormone have been mentioned in the context of this disorder. Affiliated tissues include breast, prostate and lung, and related phenotype is limbs/digits/tail.

Wikipedia : 74 Phyllodes tumors (from Greek: phullon leaf), also cystosarcoma phyllodes, cystosarcoma phylloides and... more...

Related Diseases for Benign Breast Phyllodes Tumor

Diseases in the Benign Breast Phyllodes Tumor family:

Breast Malignant Phyllodes Tumor

Diseases related to Benign Breast Phyllodes Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 252)
# Related Disease Score Top Affiliating Genes
1 breast malignant phyllodes tumor 33.3 PGR MME MED12 KIT
2 pleomorphic liposarcoma 30.6 VIM KIT
3 malignant fibrous histiocytoma 30.6 VIM MKI67 KIT
4 hidradenoma 30.5 VIM MME
5 mesenchymal cell neoplasm 30.5 MME KIT
6 ductal carcinoma in situ 30.4 PGR MME MKI67
7 breast sarcoma 30.4 PGR MME
8 breast osteosarcoma 30.4 PGR MME
9 constipation 30.4 VIM MED12 KIT
10 cribriform carcinoma 30.4 PGR KIT
11 breast fibroadenoma 30.3 PLVAP PGR MME MKI67 MED12 LCOR
12 leiomyoma, uterine 30.3 PGR MED12 IGF2
13 adenofibroma 30.3 VIM MME
14 carcinosarcoma 30.2 VIM PGR MME KIT
15 breast adenocarcinoma 30.1 PGR MED12 LCOR
16 hemangioma 30.0 PGR KIT IGF2
17 embryonal sarcoma 30.0 VIM MKI67 KIT
18 inflammatory myofibroblastic tumor 29.9 VIM MKI67 KIT
19 leiomyosarcoma 29.9 VIM PGR MED12 KIT IGF2
20 adenosarcoma 29.8 VIM PGR MME MKI67 KIT
21 gastrointestinal stromal tumor 29.4 VIM MKI67 KIT IGF2
22 leiomyoma 29.1 VIM PGR MME MKI67 MED12 KIT
23 li-fraumeni syndrome 11.7
24 li-fraumeni syndrome 2 11.7
25 benign prostate phyllodes tumor 11.5
26 rare tumor 10.7
27 overgrowth syndrome 10.7
28 breast cancer 10.6
29 sarcoma 10.6
30 spindle cell sarcoma 10.6
31 liposarcoma 10.5
32 rare breast tumor 10.5
33 fibrosarcoma 10.5
34 adenoma 10.5
35 cervical adenomyoma 10.5 PGR MME
36 fallopian tube endometriosis 10.5 PGR MME
37 cervical benign neoplasm 10.4 PGR MME
38 uterine corpus adenosarcoma 10.4 PGR MME
39 cervical serous adenocarcinoma 10.4 PGR MME
40 breast leiomyoma 10.4 PGR MME
41 urethra leiomyoma 10.4 MME KIT
42 osteogenic sarcoma 10.4
43 infant gynecomastia 10.4
44 gynecomastia 10.4
45 breast metaplastic carcinoma 10.4 PGR MME
46 cervical polyp 10.4 PGR MME
47 mucocele of appendix 10.4 MME KIT
48 liver leiomyoma 10.4 PGR KIT
49 vulvar leiomyoma 10.4 PGR MME
50 pancreatic mucinous cystadenoma 10.4 PGR MME

Graphical network of the top 20 diseases related to Benign Breast Phyllodes Tumor:



Diseases related to Benign Breast Phyllodes Tumor

Symptoms & Phenotypes for Benign Breast Phyllodes Tumor

MGI Mouse Phenotypes related to Benign Breast Phyllodes Tumor:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.02 IGF2 KIT MED12 PGR PLVAP

Drugs & Therapeutics for Benign Breast Phyllodes Tumor

Drugs for Benign Breast Phyllodes Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 1 51-21-8 3385
2
Parathyroid hormone Approved, Investigational Phase 1 9002-64-6
3
Belinostat Approved, Investigational Phase 1 866323-14-0
4 Immunologic Factors Phase 1
5 Histone Deacetylase Inhibitors Phase 1
6 Androgens Phase 1
7 Immunosuppressive Agents Phase 1
8 Antimetabolites Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase I Safety, Pharmacodynamic, Anti-Tumor Activity, and Pharmacokinetic Study of PXD101 Alone and in Combination With 5-Fluorouracil in Patients With Advanced Solid Tumors Completed NCT00413322 Phase 1 belinostat;5-Fluorouracil (5-FU)
2 A Prospective Study of Adjuvant Radiation Therapy After Resection of Borderline and Malignant Phyllodes Tumors Completed NCT00003404
3 A Prospective Study of Partial Breast Adjuvant Radiation Therapy After Resection of Borderline and Malignant Phyllodes Tumors Recruiting NCT01089374

Search NIH Clinical Center for Benign Breast Phyllodes Tumor

Cochrane evidence based reviews: phyllodes tumor

Genetic Tests for Benign Breast Phyllodes Tumor

Anatomical Context for Benign Breast Phyllodes Tumor

MalaCards organs/tissues related to Benign Breast Phyllodes Tumor:

40
Breast, Prostate, Lung, Lymph Node, Bone, Pancreas, Skin

Publications for Benign Breast Phyllodes Tumor

Articles related to Benign Breast Phyllodes Tumor:

(show top 50) (show all 899)
# Title Authors PMID Year
1
A case of a giant phyllodes tumor of the breast with hypoglycemia caused by high-molecular-weight insulin-like growth factor II. 61 54
19259766 2010
2
Expression of c-kit in fibroepithelial lesions of the breast is a mast cell phenomenon. 61 54
18500266 2008
3
Hypoglycemic coma secondary to big insulin-like growth factor II secretion by a giant phyllodes tumor of the breast. 61 54
17319862 2007
4
Amplifications of EGFR gene and protein expression of EGFR, Her-2/neu, c-kit, and androgen receptor in phyllodes tumor of the prostate. 61 54
17192792 2007
5
CD10, actin, and vimentin expression in breast phyllodes tumors correlates with tumor grades of the WHO grading system. 54 61
16703173 2006
6
p53 and c-kit (CD117) protein expression as prognostic indicators in breast phyllodes tumors: a tissue microarray study. 54 61
16258510 2005
7
Progressive deregulation of the cell cycle with higher tumor grade in the stroma of breast phyllodes tumors. 61 54
15981808 2005
8
Expression of p53 protein and Ki-67 antigen in phyllodes tumor of the breast. 54 61
15077883 2004
9
Prognostic evaluation of proliferative activity and DNA content in the phyllodes tumor of the breast: immunohistochemical and flow cytometric study of 118 cases. 61 54
11245343 2001
10
CD34, CD117, and actin expression in phyllodes tumor of the breast. 61 54
11104647 2000
11
Malignant phyllodes tumor of the breast with hypoglycemia: report of a case. 61 54
9657015 1998
12
Giant cystosarcoma phyllodes of the prostate associated with adenocarcinoma. 61 54
1310247 1992
13
Benign Phyllodes Tumor in Children: A Study of 8 Cases and Review of the Literature. 61
31107366 2020
14
Next-generation sequencing in residual liquid-based cytology specimens for cancer genome analysis. 61
32511899 2020
15
Periductal Stromal Tumors and Phyllodes Tumors Represent a Spectrum of Fibroepithelial Lesions: What Is in a Name? 61
32517525 2020
16
Pure ground glass opacity (GGO) on chest CT: a rare presentation of lung metastasis of Malignant Phyllodes Tumor. 61
32578005 2020
17
ASO Author Reflections: How Far Should We Go in Local Management for a Localized Malignant Phyllodes Tumor of the Breast? 61
32206956 2020
18
Multifocal intra-parenchymal and sub-pectoral malignant phyllodes tumor in young female, rare and unusual presentation: A case report. 61
32480338 2020
19
Pediatric Malignant Phyllodes Tumors of the Breast: Characteristics and Outcomes Based on the Surveillance Epidemiology and End Results Database. 61
31991330 2020
20
Local recurrence after breast-conserving therapy for phyllodes tumors: A 15-year retrospective review. 61
31814215 2020
21
A Radiomics Approach for the Classification of Fibroepithelial Lesions on Breast Ultrasonography. 61
32102739 2020
22
Fibroepithelial Lesions (FELs) of the Breast: Is Routine Excision Always Necessary? 61
31974650 2020
23
Cellular fibroepithelial lesions diagnosed on core needle biopsy: Is there any role of clinical-sonography features helping to differentiate fibroadenomas and phyllodes tumor? 61
32396665 2020
24
Malignant phyllodes tumor of the male breast. 61
31876033 2020
25
Recurrent borderline phyllodes tumor in nipple: a rare case report and review of the literature. 61
32420273 2020
26
Phyllodes tumor with osteosarcomatous differentiation should be followed closely: An unusual case. 61
31493305 2020
27
The Reconstruction after a Giant Phyllodes Tumor Resection Using a DIEP Flap. 61
32440428 2020
28
Patterns of care and predictors of adjuvant radiation therapy in phyllodes tumor of the breast. 61
32275108 2020
29
Expression profile and bioinformatics analysis of COMMD10 in BALB/C mice and human. 61
30787448 2020
30
Heterogeneous risk profiles among B3 breast lesions of uncertain malignant potential. 61
31451072 2020
31
Vulvar Phyllodes Tumor Presenting as an Epidermoid Cyst. 61
32248550 2020
32
Management of a periductal stromal tumor in a young woman: Our breast unit experience. 61
32297694 2020
33
Giant phyllodes tumor occupying the whole breast in a young female: feasibility of mastectomy and immediate reconstruction. 61
32280449 2020
34
Texture Analysis of Ultrasound Images to Differentiate Simple Fibroadenomas From Complex Fibroadenomas and Benign Phyllodes Tumors. 61
32329531 2020
35
Relative apparent diffusion coefficient (rADC) in breast lesions of uncertain malignant potential (B3 lesions) and pathologically proven breast carcinoma (B5 lesions) following breast biopsy. 61
32007817 2020
36
[Phyllodes tumor of the breast with heart and lung metastases: a case report]. 61
32146753 2020
37
Giant phyllodes tumor of the breast. 61
31486153 2020
38
Beta-HCG-producing phyllodes tumor. 61
31605427 2020
39
Neuroendocrine carcinoma of the breast arising in malignant phyllodes tumor. 61
31495014 2020
40
Lacrimal Sac Metastasis from Phyllodes Tumor of the Breast. 61
32037753 2020
41
A rare case of mixed type liposarcoma of breast arising in malignant phyllodes tumor. 61
31493302 2020
42
Malignant giant phyllodes tumor with heterologous osteosarcomatous differentiation and aneurysmatic bone cyst-like features. 61
32068321 2020
43
Phyllodes tumor with extensive intraductal spread radiologically mimicking ductal carcinoma in situ. 61
31538381 2020
44
Rapidly progressing malignant phyllodes tumor of the prostate with normal prostate-specific antigen levels: A case report. 61
32108628 2020
45
Phyllodes tumor of the prostate: Long-term follow up of a rare condition. 61
31641599 2020
46
[Phyllodes Tumor of the Breast Occurring near Postoperative Fibroadenoma Scar-A Case Report]. 61
32381888 2020
47
Metaplastic (adenosquamous) carcinoma in a phyllodes tumor with osseous metaplasia and ductal carcinoma in situ: A diagnostic challenge on core biopsy. 61
31909550 2020
48
Phyllodes Tumor of the Breast: A Clinicopathological Evaluation of 55 Cases. 61
31912011 2020
49
Primary Osteosarcoma of the Breast with Extensive Chondroid Matrix in a Teenager Female Patient: The Paradoxical Diagnosis in Breast Mastopathy. 61
32021493 2020
50
Characterizing excised breast masses in children and adolescents-Can a more aggressive pathology be predicted? 61
32061367 2020

Variations for Benign Breast Phyllodes Tumor

Copy number variations for Benign Breast Phyllodes Tumor from CNVD:

7
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 16441 1 124300000 247249719 Gain Phyllodes tumor
2 38178 10 1 40300000 Loss Phyllodes tumor
3 69804 12 56300000 66000000 Amplification MDM2 Phyllodes tumor
4 77646 13 46200000 48900000 Loss RB1 Phyllodes tumor
5 191456 5 1 180857866 Gain Phyllodes tumor
6 214475 6 60500000 170899992 Loss Phyllodes tumor
7 233913 8 128816946 128822855 Amplification MYC Phyllodes tumor

Expression for Benign Breast Phyllodes Tumor

Search GEO for disease gene expression data for Benign Breast Phyllodes Tumor.

Pathways for Benign Breast Phyllodes Tumor

Pathways related to Benign Breast Phyllodes Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.67 VIM MME MKI67

GO Terms for Benign Breast Phyllodes Tumor

Biological processes related to Benign Breast Phyllodes Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of MAPK cascade GO:0043410 8.8 TMEM106A KIT IGF2

Sources for Benign Breast Phyllodes Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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