MCID: BNG013
MIFTS: 41

Benign Breast Phyllodes Tumor

Categories: Cancer diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Benign Breast Phyllodes Tumor

MalaCards integrated aliases for Benign Breast Phyllodes Tumor:

Name: Benign Breast Phyllodes Tumor 12 15 73
Phyllodes Tumor, Benign 12 73
Phyllodes Tumor 44 73
Benign Phyllodes Neoplasm of the Breast 12
Benign Cystosarcoma Phyllodes 12
Benign Phyllodes Neoplasm 12
Cystosarcoma Phyllodes 12
Phyllodes Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1631
ICD10 33 D48.6
MeSH 44 D003557
SNOMED-CT 68 16566002 71232009

Summaries for Benign Breast Phyllodes Tumor

Disease Ontology : 12 A breast benign neoplasm that has_material_basis in epithelial and stromal tissue and derives from periductal stromal cells of the breast.

MalaCards based summary : Benign Breast Phyllodes Tumor, also known as phyllodes tumor, benign, is related to breast fibroadenoma and ovarian brenner tumor. An important gene associated with Benign Breast Phyllodes Tumor is PGR (Progesterone Receptor), and among its related pathways/superpathways are DNA Damage and Hematopoietic cell lineage. Affiliated tissues include breast, prostate and lung, and related phenotypes are immune system and muscle

Wikipedia : 76 Phyllodes tumors (from Greek: phullon leaf), also cystosarcoma phyllodes, cystosarcoma phylloides and... more...

Related Diseases for Benign Breast Phyllodes Tumor

Diseases in the Benign Breast Phyllodes Tumor family:

Breast Malignant Phyllodes Tumor

Diseases related to Benign Breast Phyllodes Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 130)
# Related Disease Score Top Affiliating Genes
1 breast fibroadenoma 30.8 MKI67 MME PGR
2 ovarian brenner tumor 30.3 KIT MME
3 ductal carcinoma in situ 30.1 MKI67 PGR
4 angiosarcoma 30.1 KIT VIM
5 fibromatosis 29.9 KIT VIM
6 cribriform carcinoma 29.7 KIT PGR TP63
7 leiomyosarcoma 29.5 KIT PGR VIM
8 breast malignant phyllodes tumor 11.7
9 benign prostate phyllodes tumor 11.3
10 prostate malignant phyllodes tumor 11.2
11 li-fraumeni syndrome 11.2
12 li-fraumeni syndrome 2 11.2
13 sarcoma 10.5
14 osteogenic sarcoma 10.4
15 infant gynecomastia 10.3
16 gynecomastia 10.3
17 adenocarcinoma 10.3
18 liposarcoma 10.2
19 hypoglycemia 10.2
20 scirrhous adenocarcinoma 10.2
21 breast giant fibroadenoma 10.2
22 desmoid tumor 10.2
23 soft tissue sarcoma 10.2
24 myxoid leiomyosarcoma 10.1 MME PGR
25 cervical carcinosarcoma 10.1 MME PGR
26 endometrial stromal nodule 10.1 MME PGR
27 spermatocele 10.1 MME PGR
28 breast benign neoplasm 10.1 MME PGR
29 thoracic benign neoplasm 10.1 MME PGR
30 endometrial stromal tumor 10.1 MME PGR
31 pancreatic mucinous cystadenoma 10.1 MME PGR
32 cystadenoma 10.1 MME PGR
33 in situ carcinoma 10.1
34 benign meningioma 10.1 MKI67 PGR
35 adenomyosis 10.1 MME PGR
36 adenoid basal cell carcinoma 10.1 KIT PGR
37 breast adenoid cystic carcinoma 10.1 KIT PGR
38 peritoneal benign neoplasm 10.1 KIT PGR
39 diffuse peritoneal leiomyomatosis 10.1 KIT PGR
40 oral leukoplakia 10.1 MKI67 TP63
41 malignant leydig cell tumor 10.1 KIT MME
42 rete testis adenocarcinoma 10.1 KIT MME
43 papillary thyroid microcarcinoma 10.1 MKI67 TP63
44 rete testis neoplasm 10.0 KIT MME
45 dysgerminoma of ovary 10.0 KIT PGR
46 juvenile nasopharyngeal angiofibroma 10.0 KIT PGR
47 angiomyolipoma 10.0 KIT PGR
48 pulmonary vein stenosis 10.0 KIT MKI67
49 renal oncocytoma 10.0 KIT MME
50 muscle cancer 10.0 KIT PGR

Graphical network of the top 20 diseases related to Benign Breast Phyllodes Tumor:



Diseases related to Benign Breast Phyllodes Tumor

Symptoms & Phenotypes for Benign Breast Phyllodes Tumor

MGI Mouse Phenotypes related to Benign Breast Phyllodes Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.55 KIT MME PGR TP63 VIM
2 muscle MP:0005369 9.26 KIT PGR TP63 VIM
3 no phenotypic analysis MP:0003012 8.92 KIT MKI67 PGR TP63

Drugs & Therapeutics for Benign Breast Phyllodes Tumor

Search Clinical Trials , NIH Clinical Center for Benign Breast Phyllodes Tumor

Cochrane evidence based reviews: phyllodes tumor

Genetic Tests for Benign Breast Phyllodes Tumor

Anatomical Context for Benign Breast Phyllodes Tumor

MalaCards organs/tissues related to Benign Breast Phyllodes Tumor:

41
Breast, Prostate, Lung, Thyroid, Ovary, Testis, Smooth Muscle

Publications for Benign Breast Phyllodes Tumor

Articles related to Benign Breast Phyllodes Tumor:

(show top 50) (show all 98)
# Title Authors Year
1
A Hypoglycemia-inducing Giant Borderline Phyllodes Tumor Secreting High-molecular-weight Insulin-Like Growth Factor II: Immunohistochemistry and a Western Blot Analysis. ( 29021486 )
2018
2
Well-differentiated liposarcoma of the breast arising in a background of malignant phyllodes tumor in a pregnant woman: A rare case report and review of literature. ( 30303154 )
2018
3
Distinction between phyllodes tumor and fibroadenoma in breast ultrasound using deep learning image analysis. ( 30258856 )
2018
4
Phyllodes Tumor of the Prostate With Epithelial Intestinal Metaplasia. ( 29543676 )
2018
5
Increased CD105 expression is associated with disease progression in phyllodes tumors - A report of a borderline phyllodes tumor with lung metastases and a study of 54 phyllodes tumors. ( 29414396 )
2018
6
[Breast osteosarcoma originating in a phyllodes tumor. Report of one case]. ( 29189868 )
2017
7
Molecular alterations in lesions of anogenital mammary-like glands and their mammary counterparts including hidradenoma papilliferum, intraductal papilloma, fibroadenoma and phyllodes tumor. ( 28648934 )
2017
8
Phyllodes Tumor of the Breast: 307 Treated Cases, the Largest Mexican Experience at a Single Breast Disease Institution. ( 28855932 )
2016
9
Insulin-like growth factor II messenger RNA-binding protein-3 is an indicator of malignant phyllodes tumor of the breast. ( 27137988 )
2016
10
Expression of CAF-Related Proteins Is Associated with Histologic Grade of Breast Phyllodes Tumor. ( 27881889 )
2016
11
A Case of Giant Borderline Phyllodes Tumor of the Breast Associated with Hypoglycemia. ( 27628602 )
2016
12
Heterologous Liposarcomatous Differentiation in Malignant Phyllodes Tumor is Histologically Similar but Immunohistochemically and Molecularly Distinct from Well-differentiated Liposarcoma of Soft Tissue. ( 26843318 )
2016
13
Massively parallel sequencing analysis of synchronous fibroepithelial lesions supports the concept of progression from fibroadenoma to phyllodes tumor. ( 28721388 )
2016
14
Perianal Tumor With Overlap Features of Fibroadenoma and Phyllodes Tumor Arising From Anogenital Mammary-like Glands. ( 26959694 )
2016
15
Malignant Phyllodes Tumor Including Aneurysmal Bone Cyst-Like Areas in Pregnancy - a Case Report and Review of the Literature. ( 27721719 )
2016
16
Recurrent angio-fibroma of breast masquerading as phyllodes tumor. ( 26458623 )
2015
17
Liposarcoma of the breast arising in a malignant phyllodes tumor: A case report and review of the literature. ( 26468454 )
2015
18
Pleomorphic liposarcoma arising in a malignant phyllodes tumor of breast: A rare occurrence. ( 26881623 )
2015
19
Transformation of benign fibroadenoma to malignant phyllodes tumor. ( 26331090 )
2015
20
Phyllodes Tumor of the Breast With Malignant Melanoma Component: A Case Report. ( 26113664 )
2015
21
Synchronous bilateral primary breast malignant phyllodes tumor and carcinoma of the breast with Paget's disease: a case report and review of the literature. ( 26770378 )
2015
22
Phyllodes tumor of the breast: role of Axl and ST6GalNAcII in the development of mammary phyllodes tumors. ( 24961352 )
2014
23
Collision tumor with inflammatory breast carcinoma and malignant phyllodes tumor: a case report and literature review. ( 24400686 )
2014
24
Phyllodes Tumor in Survivors of Childhood Osteosarcoma: A Single Institution's Experience. ( 24065044 )
2014
25
Expression of Yes-associated protein (YAP) in breast phyllodes tumor. ( 25337244 )
2014
26
Ductal carcinoma in situ in a benign phyllodes tumor of breast: A rare presentation. ( 25097439 )
2014
27
Fibroadenoma versus phyllodes tumor: distinguishing factors in patients diagnosed with fibroepithelial lesions after a core needle biopsy. ( 24356293 )
2014
28
Significant histologic features differentiating cellular fibroadenoma from phyllodes tumor on core needle biopsy specimens. ( 25125627 )
2014
29
Phyllodes Tumor of Anogenital Mammary-like Glands with Diffuse Pseudoangiomatous Stromal Hyperplasia. ( 24272935 )
2013
30
Expression of TWIST1, Snail, Slug, and NF-I_B and methylation of the TWIST1 promoter in mammary phyllodes tumor. ( 23150175 )
2013
31
First case of transformation for breast fibroadenoma to high-grade malignant phyllodes tumor in an in vitro fertilization patient: misdiagnosis of recurrence, treatment and review of the literature. ( 24089229 )
2013
32
Malignant phyllodes tumor and acute megakaryoblastic leukemia sharing a common clonal origin. ( 24455338 )
2013
33
Angiosarcoma in recurrent malignant phyllodes tumor of breast. ( 22771666 )
2012
34
Recurrent Mastitis after Core Needle Biopsy: Case Report of an Unusual Complication after Core Needle Biopsy of a Phyllodes Tumor. ( 22872800 )
2012
35
Invasive cribriform carcinoma arising in malignant phyllodes tumor of breast: a case report. ( 23110003 )
2012
36
Phyllodes tumor of the breast: role of CD10 in predicting metastasis. ( 22006372 )
2012
37
ER, p53 and MIB-1 are significantly associated with malignant phyllodes tumor. ( 23442362 )
2012
38
Jejunal intussusception due to malignant phyllodes tumor of the breast. ( 22381472 )
2012
39
Giant sized epidermal inclusion cyst of the breast initially mimicking a large fibroadenoma or phyllodes tumor. ( 22880186 )
2012
40
Phyllodes tumor of the prostate. ( 22360509 )
2012
41
Malignant transformation of breast fibroadenoma to malignant phyllodes tumor: long-term outcome of 36 malignant phyllodes tumors. ( 22121516 )
2011
42
Ductal carcinoma in situ arising within a benign phyllodes tumor: A case report with a review of the literature. ( 22866068 )
2011
43
Differentiation between phyllodes tumor and fibroadenoma using real-time elastography. ( 22194044 )
2011
44
A case of a giant phyllodes tumor of the breast with hypoglycemia caused by high-molecular-weight insulin-like growth factor II. ( 19259766 )
2010
45
Loss of SDHB and NF1 genes in a malignant phyllodes tumor of the breast as detected by oligo-array comparative genomic hybridization. ( 20082856 )
2010
46
Cytological clues in the distinction between phyllodes tumor and fibroadenoma. ( 20094997 )
2010
47
Distinction of phyllodes tumor from fibroadenoma: Cytologists' perspective. ( 21157551 )
2010
48
Beta-human chorionic gonadotropin production associated with phyllodes tumor of the breast: an unusual paraneoplastic phenomenon. ( 19624411 )
2009
49
Case of the season: a giant fibroadenoma in the guise of a phyllodes tumor; characterization role of MRI. ( 19233082 )
2009
50
Evidence for transformation of fibroadenoma of the breast to malignant phyllodes tumor. ( 19276971 )
2009

Variations for Benign Breast Phyllodes Tumor

Copy number variations for Benign Breast Phyllodes Tumor from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 16441 1 124300000 247249719 Gain Phyllodes tumor
2 38178 10 1 40300000 Loss Phyllodes tumor
3 69804 12 56300000 66000000 Amplification MDM2 Phyllodes tumor
4 77646 13 46200000 48900000 Loss RB1 Phyllodes tumor
5 191456 5 1 180857866 Gain Phyllodes tumor
6 214475 6 60500000 170899992 Loss Phyllodes tumor
7 233913 8 128816946 128822855 Amplification MYC Phyllodes tumor

Expression for Benign Breast Phyllodes Tumor

Search GEO for disease gene expression data for Benign Breast Phyllodes Tumor.

Pathways for Benign Breast Phyllodes Tumor

Pathways related to Benign Breast Phyllodes Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.6 MKI67 TP63 VIM
2 11.31 KIT MME
3 11.13 KIT MME
4 10.88 KIT MME
5 10.67 MKI67 MME VIM

GO Terms for Benign Breast Phyllodes Tumor

Biological processes related to Benign Breast Phyllodes Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of Notch signaling pathway GO:0045747 8.62 KIT TP63

Sources for Benign Breast Phyllodes Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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