MCID: BNG013
MIFTS: 35

Benign Breast Phyllodes Tumor

Categories: Cancer diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Benign Breast Phyllodes Tumor

MalaCards integrated aliases for Benign Breast Phyllodes Tumor:

Name: Benign Breast Phyllodes Tumor 12 15 70
Phyllodes Tumor 44 17 70
Benign Phyllodes Neoplasm of the Breast 12
Benign Cystosarcoma Phyllodes 12
Benign Phyllodes Neoplasm 12
Phyllodes Tumor, Benign 70
Cystosarcoma Phyllodes 12
Phyllodes Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1631
MeSH 44 D003557
ICD10 32 D48.6
UMLS 70 C0010701 C0334501 C1332533

Summaries for Benign Breast Phyllodes Tumor

Disease Ontology : 12 A breast benign neoplasm that has material basis in epithelial and stromal tissue and derives from periductal stromal cells of the breast.

MalaCards based summary : Benign Breast Phyllodes Tumor, also known as phyllodes tumor, is related to breast malignant phyllodes tumor and breast fibroadenoma. An important gene associated with Benign Breast Phyllodes Tumor is PGR (Progesterone Receptor), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Hematopoietic cell lineage. Affiliated tissues include breast, prostate and lymph node.

Wikipedia : 73 Phyllodes tumors (from Greek: phullon leaf), also cystosarcoma phyllodes, cystosarcoma phylloides and... more...

Related Diseases for Benign Breast Phyllodes Tumor

Diseases in the Benign Breast Phyllodes Tumor family:

Breast Malignant Phyllodes Tumor

Diseases related to Benign Breast Phyllodes Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 326)
# Related Disease Score Top Affiliating Genes
1 breast malignant phyllodes tumor 32.0 PGR MME KIT CD34
2 breast fibroadenoma 30.6 TP63 PGR MME MKI67 LCOR
3 tubular adenocarcinoma 30.4 PGR MME
4 leiomyosarcoma 30.4 VIM PGR KIT
5 hidradenoma 30.3 VIM MME
6 pleomorphic liposarcoma 30.3 VIM KIT
7 breast osteosarcoma 30.2 PGR MME
8 ductal carcinoma in situ 30.2 PGR MME MKI67
9 intraductal papilloma 30.2 TP63 PGR
10 prostate sarcoma 30.1 PGR CD34
11 fibrous histiocytoma 30.0 VIM KIT CD34
12 carcinosarcoma 30.0 VIM PGR MME KIT
13 mesenchymal cell neoplasm 29.9 MME KIT CD34
14 embryonal sarcoma 29.8 VIM MKI67 KIT
15 spindle cell sarcoma 29.8 VIM KIT CD34
16 angiosarcoma 29.8 VIM KIT CD34
17 cribriform carcinoma 29.8 TP63 PGR KIT
18 mammary paget's disease 29.7 PGR LCOR
19 desmoid tumor 29.7 MKI67 KIT CD34
20 intussusception 29.7 KIT CD34
21 breast sarcoma 29.7 PGR MME CD34
22 adenosarcoma 29.6 VIM PGR MME MKI67 KIT
23 neurilemmoma 29.5 VIM KIT CD34
24 hemangioma 29.3 VIM PGR KIT CD34
25 leiomyoma 29.2 VIM PGR MME MKI67 KIT CD34
26 inflammatory myofibroblastic tumor 29.1 VIM MKI67 KIT CD34
27 leukemia, acute myeloid 29.0 MME LCOR KIT CD34
28 benign prostate phyllodes tumor 11.3
29 li-fraumeni syndrome 11.1
30 li-fraumeni syndrome 2 11.1
31 rare tumor 10.6
32 overgrowth syndrome 10.6
33 liposarcoma 10.4
34 rare breast tumor 10.4
35 fibrosarcoma 10.4
36 cervical adenomyoma 10.3 PGR MME
37 adenomyoma 10.3 PGR MME
38 cervical benign neoplasm 10.3 PGR MME
39 uterine corpus adenosarcoma 10.3 PGR MME
40 fallopian tube endometriosis 10.3 PGR MME
41 cervical serous adenocarcinoma 10.3 PGR MME
42 breast metaplastic carcinoma 10.3 PGR MME
43 pancreatic mucinous cystadenoma 10.3 PGR MME
44 ovarian endometrioid stromal sarcoma 10.3 PGR MME
45 comedo carcinoma 10.3 PGR LCOR
46 osteogenic sarcoma 10.3
47 infant gynecomastia 10.3
48 gynecomastia 10.3
49 soft tissue sarcoma 10.3
50 cutaneous adenocystic carcinoma 10.3 PGR MME

Graphical network of the top 20 diseases related to Benign Breast Phyllodes Tumor:



Diseases related to Benign Breast Phyllodes Tumor

Symptoms & Phenotypes for Benign Breast Phyllodes Tumor

Drugs & Therapeutics for Benign Breast Phyllodes Tumor

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Prospective Study of Adjuvant Radiation Therapy After Resection of Borderline and Malignant Phyllodes Tumors Completed NCT00003404
2 A Prospective Study of Partial Breast Adjuvant Radiation Therapy After Resection of Borderline and Malignant Phyllodes Tumors Recruiting NCT01089374
3 Pilot Study on the Feasibility of Cryotherapy as an Alternative Treatment for Phyllodes Tumors/Breast Fibroepithelial Lesions (FELs) Needing Surgery Recruiting NCT04571307

Search NIH Clinical Center for Benign Breast Phyllodes Tumor

Cochrane evidence based reviews: phyllodes tumor

Genetic Tests for Benign Breast Phyllodes Tumor

Anatomical Context for Benign Breast Phyllodes Tumor

MalaCards organs/tissues related to Benign Breast Phyllodes Tumor:

40
Breast, Prostate, Lymph Node, Pancreas, Bone, Brain, Skin

Publications for Benign Breast Phyllodes Tumor

Articles related to Benign Breast Phyllodes Tumor:

(show top 50) (show all 959)
# Title Authors PMID Year
1
A case of a giant phyllodes tumor of the breast with hypoglycemia caused by high-molecular-weight insulin-like growth factor II. 61 54
19259766 2010
2
Expression of c-kit in fibroepithelial lesions of the breast is a mast cell phenomenon. 61 54
18500266 2008
3
Hypoglycemic coma secondary to big insulin-like growth factor II secretion by a giant phyllodes tumor of the breast. 54 61
17319862 2007
4
Amplifications of EGFR gene and protein expression of EGFR, Her-2/neu, c-kit, and androgen receptor in phyllodes tumor of the prostate. 54 61
17192792 2007
5
CD10, actin, and vimentin expression in breast phyllodes tumors correlates with tumor grades of the WHO grading system. 61 54
16703173 2006
6
p53 and c-kit (CD117) protein expression as prognostic indicators in breast phyllodes tumors: a tissue microarray study. 54 61
16258510 2005
7
Progressive deregulation of the cell cycle with higher tumor grade in the stroma of breast phyllodes tumors. 61 54
15981808 2005
8
Expression of p53 protein and Ki-67 antigen in phyllodes tumor of the breast. 54 61
15077883 2004
9
Prognostic evaluation of proliferative activity and DNA content in the phyllodes tumor of the breast: immunohistochemical and flow cytometric study of 118 cases. 61 54
11245343 2001
10
CD34, CD117, and actin expression in phyllodes tumor of the breast. 61 54
11104647 2000
11
Malignant phyllodes tumor of the breast with hypoglycemia: report of a case. 54 61
9657015 1998
12
Giant cystosarcoma phyllodes of the prostate associated with adenocarcinoma. 61 54
1310247 1992
13
Phyllodes tumor of the breast clinical experience and outcomes: A retrospective cohort tertiary hospital experience. 61
33472142 2021
14
Outcomes of systemic therapy in metastatic phyllodes tumor of the breast. 61
33575859 2021
15
Benign and borderline phyllodes tumors of the breast: Clinicopathologic analysis of 205 cases with emphasis on the surgical margin status and local recurrence rate. 61
33513547 2021
16
[A Case of a Malignant Phyllodes Tumor in the Breast with Lymph Node Metastasis]. 61
33790180 2021
17
Incidental Pathologic Findings in Young Adult Reduction Mammaplasty. 61
33620923 2021
18
Breast complaints in children and the effect of family history. 61
32745292 2021
19
The significance of enhancer of zeste homolog 2 (EZH2) expression in spindle cell lesions of the breast. 61
33730427 2021
20
Detection of MED12 mutations in mesenchymal components of uterine adenomyomas. 61
33259844 2021
21
Chemotherapy and targeted treatments of breast sarcoma by histologic subtype. 61
33554686 2021
22
Impact of RASSF1A gene methylation on clinico-pathological features of tumor and non-tumor tissue of breast cancer. 61
33621744 2021
23
Giant Juvenile Fibroadenoma of the breast in a 13-year-old Pakistani girl with excellent cosmetic outcome after subareolar enucleation - A case report. 61
33757260 2021
24
[Prognosis analysis of local recurrence after excision of breast phyllodes tumors]. 61
33378803 2021
25
Periductal Stromal Tumors and Phyllodes Tumors Represent a Spectrum of Fibroepithelial Lesions: What Is in a Name? 61
32517525 2021
26
Malignant Phyllodes Tumor of the Breast With Metastasis to the Orbit: A Rare Case Report. 61
32732545 2021
27
The role of adjuvant radiotherapy in patients with malignant phyllodes tumor of the breast: a propensity-score matching analysis. 61
32748225 2021
28
Granulocyte-colony stimulating factor-producing malignant phyllodes tumor of the breast: a rare case. 61
33447858 2021
29
Phyllodes Tumors of the Breast: A Single-Center Experience. 61
33796829 2021
30
Predictive Factors of Early Recurrence in Patients with Phyllodes Tumor of the Breast. 61
33796825 2021
31
Giant Benign Mammary Phyllodes Tumor: Report of a Case and Review of the Literature. 61
33776693 2021
32
The limited role of ultrasound in the surgical assessment of solid pediatric breast lesions. 61
33465666 2021
33
Periductal stromal tumor of the breast in a young lady: A case report. 61
33474791 2021
34
Pancreatic metastasis from malignant phyllodes tumor of the breast. 61
33242383 2021
35
Fatal outcome of malignant phyllodes tumor of the breast in pregnancy: a case and literature review. 61
33633994 2021
36
Report of Two Cases with Simultaneously Detected Tubular Carcinoma and Phyllodes Tumor of the Breast. 61
33796835 2021
37
Identification of PKHD1 mutations in Brain, Breast and Rectal tumors by Next Generation DNA Sequencing. 61
33716212 2021
38
Non-invasive ductal carcinoma within malignant phyllodes tumor of the breast. 61
33473040 2021
39
[Treatment Regimens for Breast Cancer in Elderly Patients in Whom the Diagnosis Was Switched from Malignant Phyllodes Tumor to Spindle-Cell Carcinoma after Surgery]. 61
33468796 2020
40
High expression of microRNA20b is associated with malignant clinicopathological features and poor prognosis in breast phyllodes tumor. 61
32803488 2020
41
Malignant phyllodes tumor with liposarcomatous differentiation: Diagnosed on cytology. 61
33378115 2020
42
[Study of Phyllodes Tumor of the Breast in 44 Cases of Resection]. 61
33468770 2020
43
The implications of neighborhood socioeconomic status on surgical management and mortality in malignant phyllodes patients in the Surveillance, Epidemiology, and End Results program. 61
32847674 2020
44
World's Oldest Case of Synchronous Bilateral Benign Phyllodes Tumors of the Breast: A Rare Occurrence. 61
33520491 2020
45
Malignant phyllodes tumor of the breast with rapid progression: a case report. 61
33284362 2020
46
Extramammary Borderline Phyllodes Tumor Presenting as an Umbilical Mass. 61
33345669 2020
47
Giant malignant phyllodes tumor of the breast: Insights into optimal management and reconstructive options for a rare and challenging entity. 61
33108821 2020
48
A case of recurrent malignant phyllodes tumor undergoing nipple-sparing mastectomy with immediate breast reconstruction. 61
33237380 2020
49
Malignant phyllodes tumor with extensive lipomatous differentiation. 61
32994850 2020
50
Early-onset malignant phyllodes breast tumor in a patient with germline pathogenic variants in NF1 and BRCA1 genes. 61
33210232 2020

Variations for Benign Breast Phyllodes Tumor

Copy number variations for Benign Breast Phyllodes Tumor from CNVD:

7
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 16441 1 124300000 247249719 Gain Phyllodes tumor
2 38178 10 1 40300000 Loss Phyllodes tumor
3 69804 12 56300000 66000000 Amplification MDM2 Phyllodes tumor
4 77646 13 46200000 48900000 Loss RB1 Phyllodes tumor
5 191456 5 1 180857866 Gain Phyllodes tumor
6 214475 6 60500000 170899992 Loss Phyllodes tumor
7 233913 8 128816946 128822855 Amplification MYC Phyllodes tumor

Expression for Benign Breast Phyllodes Tumor

Search GEO for disease gene expression data for Benign Breast Phyllodes Tumor.

Pathways for Benign Breast Phyllodes Tumor

Pathways related to Benign Breast Phyllodes Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.5 MME KIT CD34
2 11.33 MME KIT CD34
3 11 VIM MME MKI67
4 10.67 MME KIT CD34

GO Terms for Benign Breast Phyllodes Tumor

Biological processes related to Benign Breast Phyllodes Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 paracrine signaling GO:0038001 8.62 PGR CD34

Molecular functions related to Benign Breast Phyllodes Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.1 ZNF350 TP63 PGR PEG10 MKI67 LCOR

Sources for Benign Breast Phyllodes Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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