MCID: BNG030
MIFTS: 50

Benign Ependymoma

Categories: Cancer diseases, Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Benign Ependymoma

MalaCards integrated aliases for Benign Ependymoma:

Name: Benign Ependymoma 12 15
Ependymoma 44 73
Who Grade Ii Ependymal Tumor 12
Myxopapillary Ependymoma 73
Epithelial Ependymoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4844
MeSH 44 D004806
NCIt 50 C3017
SNOMED-CT 68 57706008

Summaries for Benign Ependymoma

MalaCards based summary : Benign Ependymoma, also known as ependymoma, is related to anaplastic ependymoma and cellular ependymoma, and has symptoms including back pain An important gene associated with Benign Ependymoma is TSC2 (TSC Complex Subunit 2), and among its related pathways/superpathways are Regulation of lipid metabolism Insulin signaling-generic cascades and AMP-activated Protein Kinase (AMPK) Signaling. Affiliated tissues include brain, spinal cord and bone, and related phenotypes are behavior/neurological and nervous system

Related Diseases for Benign Ependymoma

Diseases in the Ependymoma family:

Benign Ependymoma Malignant Ependymoma
Malignant Adult Ependymoma

Diseases related to Benign Ependymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 293)
# Related Disease Score Top Affiliating Genes
1 anaplastic ependymoma 33.9 GFAP NF2 SYP
2 cellular ependymoma 33.5 GFAP SYP
3 malignant ependymoma 33.5 GFAP NF2
4 clear cell ependymoma 33.3 ENO2 GFAP SYP
5 spinal cord ependymoma 33.2 EPB41L3 NF2
6 papillary ependymoma 33.0 ENO2 GFAP RBFOX3 SYP
7 tanycytic ependymoma 32.9 GFAP NF2 RBFOX3 SYP
8 subependymoma 31.9 ENO2 GFAP SYP TSC2
9 neurofibromatosis, type ii 31.5 EPB41L3 NF2
10 subependymal glioma 30.7 ENO2 GFAP KCTD1 MTOR SYP TSC1
11 papilloma of choroid plexus 30.3 GFAP SYP
12 hydrocephalus 30.3 ENO2 GFAP SYP
13 hemangioblastoma 30.2 ENO2 GFAP SYP
14 angiocentric glioma 30.2 GFAP SYP
15 oligodendroglioma 30.1 ENO2 GFAP SYP
16 teratoma 30.1 ENO2 GFAP SYP
17 atypical teratoid rhabdoid tumor 29.9 GFAP SYP
18 chordoid meningioma 29.9 GFAP SYP
19 medulloepithelioma 29.8 GFAP SYP
20 renal cell carcinoma, nonpapillary 29.8 MTOR TSC1 TSC2
21 spinal meningioma 29.8 ENO2 NF2
22 rhabdoid cancer 29.7 ENO2 SYP
23 ganglioglioma 29.7 ENO2 GFAP SYP TSC2
24 carcinoid syndrome 29.6 ENO2 SYP
25 astroblastoma 29.6 ENO2 GFAP SYP
26 central neurocytoma 29.6 ENO2 GFAP SYP
27 cystic teratoma 29.6 ENO2 GFAP SYP
28 ganglioneuroma 29.6 ENO2 GFAP SYP
29 neuroma 29.5 ENO2 GFAP NF2
30 ependymoma 29.5 ENO2 GFAP NF2 SYP
31 meningioma, familial 28.8 ENO2 EPB41L3 GFAP NF2 SYP
32 myxopapillary ependymoma 12.5
33 pediatric ependymoma 12.5
34 adult brain ependymoma 12.2
35 pediatric supratentorial ependymoma 12.2
36 brain ependymoma 12.1
37 pediatric infratentorial ependymoma 12.1
38 low grade ependymoma 12.1
39 mixed astrocytoma-ependymoma 12.0
40 brain stem ependymoma 12.0
41 malignant adult ependymoma 12.0
42 adult spinal cord ependymoma 12.0
43 mixed astrocytoma-ependymoma-oligodendroglioma 12.0
44 parietal lobe ependymoma 11.9
45 medulloblastoma 11.4
46 glioma 11.4
47 multiple endocrine neoplasia, type i 11.4
48 glioma susceptibility 1 11.2
49 glioma susceptibility 2 11.0
50 glioma susceptibility 3 11.0

Graphical network of the top 20 diseases related to Benign Ependymoma:



Diseases related to Benign Ependymoma

Symptoms & Phenotypes for Benign Ependymoma

UMLS symptoms related to Benign Ependymoma:


back pain

MGI Mouse Phenotypes related to Benign Ependymoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.56 ENO2 EPB41L3 GFAP MTOR NF2 SYP
2 nervous system MP:0003631 9.23 ENO2 EPB41L3 GFAP MTOR NF2 SYP

Drugs & Therapeutics for Benign Ependymoma

Search Clinical Trials , NIH Clinical Center for Benign Ependymoma

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: ependymoma

Genetic Tests for Benign Ependymoma

Anatomical Context for Benign Ependymoma

MalaCards organs/tissues related to Benign Ependymoma:

41
Brain, Spinal Cord, Bone, Liver, Pineal, Lung, Kidney

Publications for Benign Ependymoma

Articles related to Benign Ependymoma:

(show top 50) (show all 237)
# Title Authors Year
1
Pineal Anaplastic Ependymoma With Multifocal Intradural Extramedullary Metastases on MRI and 18FDG-PET. ( 30080187 )
2018
2
Preoperative and intraoperative perfusion magnetic resonance imaging in a RELA fusion-positive anaplastic ependymoma: A case report. ( 30105138 )
2018
3
Pediatric Case of Li-Fraumeni Syndrome Complicated with Supratentorial Anaplastic Ependymoma. ( 30196175 )
2018
4
Microsurgical Resection of Anaplastic Ependymoma of the Cerebellopontine Angle in an Adult: 3-Dimensional Operative Video. ( 30295880 )
2018
5
Intramedullary spinal cord ependymoma and astrocytoma: intraoperative frozen-section diagnosis, extent of resection, and outcomes. ( 30485241 )
2018
6
Clinical, radiological, and histological features and treatment outcomes of supratentorial extraventricular ependymoma: 14 cases from a single center. ( 28686116 )
2018
7
Pituitary Ependymoma: A Case Report and Review of the Literature. ( 29102750 )
2018
8
Impact of radiation therapy and extent of resection for ependymoma in young children: A population-based study. ( 29115718 )
2018
9
MRI Characteristics of Spinal Ependymoma in WHO Grade II: A Review of 59 Cases. ( 29189641 )
2018
10
Metastases of spinal myxopapillary ependymoma: unique characteristics and clinical management. ( 29219779 )
2018
11
Remarkable efficacy of temozolomide for relapsed spinal myxopapillary ependymoma with multiple recurrence and cerebrospinal dissemination: a case report and literature review. ( 29270703 )
2018
12
Patterns of relapse for children with localized intracranial ependymoma. ( 29511977 )
2018
13
Spinal ependymoma in adults: a multicenter investigation of surgical outcome and progression-free survival. ( 29521579 )
2018
14
Ependymoma. ( 29548057 )
2018
15
Heterogeneity within the PF-EPN-B ependymoma subgroup. ( 30019219 )
2018
16
MRI Phenotype of RELA-fused Pediatric Supratentorial Ependymoma. ( 30027327 )
2018
17
Is NF2 a Key Player of the Differentially Expressed Gene Between Spinal Cord Ependymoma and Intracranial Ependymoma? ( 30031196 )
2018
18
Predictors of Functional Outcome after Spinal Ependymoma Resection. ( 30069091 )
2018
19
Analysis of Multimodal Intraoperative Monitoring During Intramedullary Spinal Ependymoma Surgery. ( 30096497 )
2018
20
MRI Characteristics of Spinal Ependymoma in WHO Grade II: A Review of 59 Cases: Erratum. ( 30102672 )
2018
21
Fourth ventricle ependymoma mimicking benign paroxysmal positional vertigo. ( 30104227 )
2018
22
High Cervical Ependymoma Resection: 2-Dimensional Operative Video. ( 30107551 )
2018
23
Pediatric intracranial ependymoma: correlating signs and symptoms at recurrence with outcome in the second prospective AIEOP protocol follow-up. ( 30109673 )
2018
24
Second cancer risk after radiation therapy of ependymoma using the flattening filter free irradiation mode of a linear accelerator. ( 30125453 )
2018
25
Clinical outcomes of radiotherapy for spinal cord ependymoma with adverse prognostic features: a single-center study. ( 30203166 )
2018
26
Variety of preoperative MRI changes in spinal cord ependymoma of WHO grade II: a case series. ( 30209583 )
2018
27
Cervical Spinal Ependymoma With Hemorrhage in a Renal Transplant Patient. ( 30251937 )
2018
28
Association of MicroRNAs with the Clinicopathologic Characteristics of Ependymoma. ( 30255441 )
2018
29
Unedited microneurosurgery of a fourth ventricular ependymoma. ( 30283719 )
2018
30
Myxopapillary ependymoma with anaplastic features: A case report with review of the literature. ( 30294495 )
2018
31
Isolated myxopapillary ependymoma of the fourth ventricle: case report and review of literature. ( 30317890 )
2018
32
The Natural Course of Myxopapillary Ependymoma : An Unusual Case Report and Review of The Literature. ( 30321682 )
2018
33
Unusual features of ependymoma in a patient with Parkinson's disease. ( 30409527 )
2018
34
Pediatric ependymoma: current treatment and newer therapeutic insights. ( 30418040 )
2018
35
Long-Term Supratentorial Radiologic Effects of Surgery and Local Radiation in Children with Infratentorial Ependymoma. ( 30448581 )
2018
36
Craniospinal irradiation as part of re-irradiation for children with recurrent intracranial ependymoma. ( 30452715 )
2018
37
Infusion of 5-Azacytidine (5-AZA) into the fourth ventricle or resection cavity in children with recurrent posterior Fossa Ependymoma: a pilot clinical trial. ( 30460634 )
2018
38
Microsurgical Gross Total Resection of a WHO Grade II Cerebellopontine Angle Ependymoma in an Adult. ( 30473984 )
2018
39
Tumor-infiltrating immune cell subpopulations and programmed death ligand 1 (PD-L1) expression associated with clinicopathological and prognostic parameters in ependymoma. ( 30483834 )
2018
40
Lumbar epidural analgesia for labor in a parturient with a history of surgery for lumbar intradural ependymoma: Literature review and case presentation. ( 30488009 )
2018
41
Radiosurgery or hypofractionated stereotactic radiotherapy after craniospinal irradiation in children and adults with medulloblastoma and ependymoma. ( 30515559 )
2018
42
Surgical outcome in cortical ependymoma: A single centre experience of 18 cases. ( 30528353 )
2018
43
Tanycytic ependymoma of filum terminale: Clinical characteristics and surgical outcomes. ( 30546423 )
2018
44
Neurocognitive, academic and functional outcomes in survivors of infant ependymoma (UKCCSG CNS 9204). ( 30554263 )
2018
45
Benign ependymoma with extensive intracranial and spinal cerebrospinal fluid dissemination: case report and literature review. ( 28633540 )
2017
46
Hormonal based treatment of ovarian anaplastic ependymoma with anastrozole. ( 28393092 )
2017
47
A case of clear cell ependymoma with bizarre aggressiveness: Are we underestimating its ferocity? ( 28879912 )
2017
48
Clinical presentation and outcomes for adult ependymoma patients. ( 27679985 )
2017
49
Intraoperative squash cytology and histology of giant cell ependymoma: A diagnostic dilemma. ( 28182061 )
2017
50
Intraocular Ependymoma With Blood-Filled Spaces: Neoplasm or a Reactive Process With Ependymal Differentiation-A Dilemma. ( 28193095 )
2017

Variations for Benign Ependymoma

Expression for Benign Ependymoma

Search GEO for disease gene expression data for Benign Ependymoma.

Pathways for Benign Ependymoma

Pathways related to Benign Ependymoma according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.65 MTOR NF2 TSC1 TSC2
2
Show member pathways
12.21 MTOR TSC1 TSC2
3
Show member pathways
12.19 MTOR TSC1 TSC2
4
Show member pathways
12.17 MTOR TSC1 TSC2
5
Show member pathways
12.16 MTOR TSC1 TSC2
6
Show member pathways
12.07 MTOR TSC1 TSC2
7 12.02 MTOR TSC1 TSC2
8
Show member pathways
11.98 MTOR TSC1 TSC2
9
Show member pathways
11.95 MTOR TSC1 TSC2
10 11.9 MTOR TSC1 TSC2
11 11.89 ENO2 GFAP NF2 RBFOX3 SYP
12 11.88 MTOR TSC1 TSC2
13 11.87 MTOR TSC1 TSC2
14
Show member pathways
11.85 MTOR TSC1 TSC2
15
Show member pathways
11.83 MTOR TSC1 TSC2
16 11.72 MTOR TSC1 TSC2
17 11.51 MTOR TSC1 TSC2
18 11.33 MTOR TSC1 TSC2
19 11.22 MTOR TSC1 TSC2
20 11.07 MTOR TSC2
21 11.06 MTOR TSC1 TSC2
22 11 MTOR TSC2
23 10.97 MTOR NF2 TSC1 TSC2
24 10.86 MTOR TSC1 TSC2
25 10.71 MTOR TSC1

GO Terms for Benign Ependymoma

Cellular components related to Benign Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 postsynaptic density GO:0014069 9.13 EPB41L3 TSC1 TSC2
2 TSC1-TSC2 complex GO:0033596 8.62 TSC1 TSC2

Biological processes related to Benign Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of cell cycle GO:0051726 9.54 NF2 TSC1 TSC2
2 negative regulation of TOR signaling GO:0032007 9.48 TSC1 TSC2
3 negative regulation of insulin receptor signaling pathway GO:0046627 9.46 TSC1 TSC2
4 positive regulation of macroautophagy GO:0016239 9.43 TSC1 TSC2
5 regulation of protein kinase activity GO:0045859 9.4 MTOR TSC1
6 positive regulation of glial cell proliferation GO:0060252 9.32 GFAP MTOR
7 negative regulation of macroautophagy GO:0016242 9.26 MTOR TSC1
8 anoikis GO:0043276 9.16 MTOR TSC2
9 negative regulation of cell size GO:0045792 8.96 MTOR TSC1
10 positive regulation of stress fiber assembly GO:0051496 8.8 MTOR NF2 TSC1

Molecular functions related to Benign Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Hsp90 protein binding GO:0051879 8.62 TSC1 TSC2

Sources for Benign Ependymoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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