MCID: BNG021
MIFTS: 37

Benign Essential Hypertension

Categories: Blood diseases, Cancer diseases, Cardiovascular diseases, Genetic diseases, Nephrological diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Benign Essential Hypertension

MalaCards integrated aliases for Benign Essential Hypertension:

Name: Benign Essential Hypertension 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:10913
ICD9CM 34 401.1
NCIt 50 C3656
SNOMED-CT 67 194758001
UMLS 70 C0155583

Summaries for Benign Essential Hypertension

MalaCards based summary : Benign Essential Hypertension is related to hypokalemia and hypertension, essential. An important gene associated with Benign Essential Hypertension is REN (Renin), and among its related pathways/superpathways are Signaling events mediated by PTP1B and Development_Leptin signaling via JAK/STAT and MAPK cascades. Affiliated tissues include pituitary, kidney and heart, and related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Benign Essential Hypertension

Diseases in the Familial Hypertension family:

Hypertension, Essential Hypertension, Essential 1
Hypertension, Essential 2 Hypertension, Essential 3
Hypertension, Essential 4 Hypertension, Essential 5
Hypertension, Essential 6 Hypertension, Essential 7
Hypertension, Essential 8 Malignant Essential Hypertension
Malignant Hypertension Benign Essential Hypertension
Benign Secondary Hypertension Malignant Secondary Hypertension
Hypertension Due to Gain-of-Function Mutations in the Mineralocorticoid Receptor

Diseases related to Benign Essential Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 302)
# Related Disease Score Top Affiliating Genes
1 hypokalemia 29.8 REN POMC INS ALB
2 hypertension, essential 29.6 REN PRL POMC JAK2 INS CRP
3 orthostatic proteinuria 10.4 REN ALB
4 supine hypotensive syndrome 10.4 REN AVP
5 hypertensive encephalopathy 10.3 REN ALB
6 kidney papillary necrosis 10.3 REN ALB
7 perinephritis 10.3 REN CYGB
8 retinal microaneurysm 10.3 REN INS
9 serous labyrinthitis 10.3 AVP ALB
10 secondary adrenal insufficiency 10.3 INS AVP
11 tarsal tunnel syndrome 10.3 OSTF1 GNPTAB
12 tibial neuropathy 10.3 OSTF1 GNPTAB
13 potter's syndrome 10.3 REN INS
14 acute adrenal insufficiency 10.3 REN POMC
15 hypoaldosteronism 10.3 REN POMC
16 renal artery disease 10.3 REN ALB
17 premenstrual tension 10.3 REN POMC
18 central pontine myelinolysis 10.3 AVP ALB
19 subacute glomerulonephritis 10.3 POMC ALB
20 pyeloureteritis cystica 10.3 REN CRP
21 marasmus 10.3 INS ALB
22 inhibited female orgasm 10.2 PRL ALB
23 arteriolosclerosis 10.2 REN ALB
24 chronic duodenal ileus 10.2 CRP ALB
25 renal tuberculosis 10.2 REN CRP
26 acute cor pulmonale 10.2 REN CRP
27 urogenital tuberculosis 10.2 REN CRP
28 folic acid deficiency anemia 10.2 CYGB CRP
29 hepatorenal syndrome 10.2 REN AVP ALB
30 cholesterol embolism 10.2 REN CRP
31 intracranial abscess 10.2 NANP CRP
32 peptic ulcer perforation 10.2 CRP ALB
33 anterior cerebral artery infarction 10.2 PRL AVP
34 ankylosing spondylitis 3 10.2 CRP ALB
35 ankylosing spondylitis 1 10.2 CRP ALB
36 tuberculous peritonitis 10.2 CRP ALB
37 superior mesenteric artery syndrome 10.2 CRP AVP
38 chronic intestinal vascular insufficiency 10.2 CRP ALB
39 acalculous cholecystitis 10.2 CRP ALB
40 meningovascular neurosyphilis 10.2 CRP ALB
41 hydrops of gallbladder 10.2 CRP ALB
42 splenic abscess 10.2 CRP ALB
43 ascending cholangitis 10.2 CRP ALB
44 duodenal obstruction 10.2 CRP ALB
45 gastrointestinal tuberculosis 10.2 CRP ALB
46 severe nonproliferative diabetic retinopathy 10.2 REN INS ALB
47 intestinal tuberculosis 10.2 CRP ALB
48 kidney hypertrophy 10.2 REN INS ALB
49 aspiration pneumonitis 10.2 CRP ALB
50 olfactory nerve neoplasm 10.2 POMC AVP

Comorbidity relations with Benign Essential Hypertension via Phenotypic Disease Network (PDN): (show all 41)


Active Peptic Ulcer Disease Acute Cystitis
Anxiety Aortic Valve Disease 1
Basilar Artery Insufficiency Benign Hypertensive Renal Disease
Benign Renovascular Hypertension Bronchitis
Cerebral Atherosclerosis Cerebrovascular Disease
Chronic Kidney Disease Deficiency Anemia
Diabetic Polyneuropathy Dressler's Syndrome
Dysthymic Disorder Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Esophagitis Familial Atrial Fibrillation
First-Degree Atrioventricular Block Generalized Atherosclerosis
Gout Heart Disease
Hyperlipoproteinemia, Type V Hypertensive Encephalopathy
Hypoglycemia Hypothyroidism
Intermediate Coronary Syndrome Intracranial Embolism
Intracranial Thrombosis Iron Deficiency Anemia
Labyrinthitis Malignant Essential Hypertension
Microvascular Complications of Diabetes 1 Mitral Valve Disease
Osteoarthritis Osteoporosis
Peripheral Vascular Disease Right Bundle Branch Block
Sinoatrial Node Disease Transient Cerebral Ischemia
Vertebral Artery Insufficiency

Graphical network of the top 20 diseases related to Benign Essential Hypertension:



Diseases related to Benign Essential Hypertension

Symptoms & Phenotypes for Benign Essential Hypertension

MGI Mouse Phenotypes related to Benign Essential Hypertension:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10 ALB AVP CFB CRP CYGB GNPTAB
2 cardiovascular system MP:0005385 9.97 ALB CFB CRP CYGB GNPTAB INS
3 immune system MP:0005387 9.85 ALB AVP CFB CRP GNPTAB INS
4 normal MP:0002873 9.5 ALB AVP CFB GNPTAB INS JAK2
5 renal/urinary system MP:0005367 9.23 ALB AVP CFB CYGB GNPTAB INS

Drugs & Therapeutics for Benign Essential Hypertension

Search Clinical Trials , NIH Clinical Center for Benign Essential Hypertension

Genetic Tests for Benign Essential Hypertension

Anatomical Context for Benign Essential Hypertension

MalaCards organs/tissues related to Benign Essential Hypertension:

40
Pituitary, Kidney, Heart, Bone, Cortex, Colon, Liver

Publications for Benign Essential Hypertension

Articles related to Benign Essential Hypertension:

(show top 50) (show all 101)
# Title Authors PMID Year
1
Differences in preeclampsia rates between African American and Caucasian women: trends from the National Hospital Discharge Survey. 61
25211000 2014
2
Clinical usefulness of a timed overnight (8 hours) Urine Albumin (microalbumin) excretion in monitor-ing treatment in benign essential hypertension. 61
25126874 2014
3
Renal vasculature in essential hypertension: a review of some contrarian evidence. 61
21252530 2011
4
Pathogenesis of structural vascular changes in hypertension. 61
15106784 2004
5
Risk stratification in hypertension: new insights from the Framingham Study. 61
10678282 2000
6
The heterogeneity of vascular findings in the kidneys of patients with benign essential hypertension. 61
10435870 1999
7
Severe neuromuscular complications possibly associated with amlodipine. 61
9825082 1998
8
Kidney damage in 'benign' essential hypertension. 61
9146981 1997
9
Does non-malignant essential hypertension cause renal damage? A clinician's view. 61
9004097 1996
10
'Benign' essential hypertension and kidney damage: a histopathologist's view. 61
9004096 1996
11
Microalbuminuria: prognostic and therapeutic implications in diabetic and hypertensive pregnancy. 61
7587001 1995
12
Alterations in intracellular cations and cell membrane ATPase activity in patients with malignant hypertension. 61
8557964 1995
13
Clinical features of end-stage renal failure in patients with essential hypertension. 61
8022111 1994
14
[Japanese clinical statistical data of patients with benign essential hypertension]. 61
1344352 1992
15
Enalapril to lisinopril: economic impact of a voluntary angiotensin-converting enzyme-inhibitor substitution program in a staff-model health maintenance organization. 61
1313320 1992
16
[Microalbuminuria in essential hypertension and normal kidney function]. 61
1553822 1992
17
A comparative study of atenolol, nifedipine and their combination in the treatment of hypertension. 61
1986440 1991
18
The role of Na,K-ATPase inhibitor on pressor responsiveness in patients with benign essential hypertension. 61
2157465 1990
19
Long-term lipid profiles with isradipine and hydrochlorothiazide treatment in elderly hypertensive patients. 61
1695313 1990
20
Vasopressin and hypertension in man. 61
2434762 1986
21
Hypertension as related to renal function in diabetes mellitus. 61
4077237 1985
22
Effects of the dopaminergic agonist cianergoline on blood pressure, the renin-angiotensin-aldosterone axis and the sympathetic nervous system in patients with essential hypertension. 61
4054204 1985
23
Plasma cortisol and beta-endorphin immunoreactivity in human obesity. 61
6093183 1984
24
Renal function in old age and uncomplicated benign essential hypertension. 61
6525640 1984
25
Circulatory volume in essential hypertension. Relationships with age, blood pressure, exchangeable sodium, renin, aldosterone and catecholamines. 61
6387428 1984
26
Body sodium blood volume state in essential hypertension: abnormal relation of exchangeable sodium to age and blood pressure in male patients. 61
6204132 1984
27
Experiences with Chlortalidone treatment in benign essential hypertension cases. 61
6546265 1984
28
Plasma vasopressin and blood pressure. Studies in normal subjects and in benign essential hypertension at rest and after postural challenge. 61
6849715 1983
29
Indoramin as second step therapy in the management of benign essential hypertension. 61
6353433 1983
30
Role of the aldosterone system in the salt-sensitivity of patients with benign essential hypertension. 61
6343666 1983
31
Urinary excretion of catecholamines in patients with primary aldosteronism before and after unilateral adrenalectomy. 61
6671385 1983
32
Acute effects of prizidilol on blood pressure, heart rate, catecholamines, renin and aldosterone in essential hypertension. 61
6129141 1982
33
Evaluation of plasma renin activity by blood pressure level (pressure-renin index) in patients with essential hypertension. 61
7050456 1982
34
[Guanfacine versus alpha-methyldopa in benign essential hypertension. An ambulatory group study]. 61
7036334 1981
35
[Treatment of benign essential hypertension with an association of spironolactone and thiabutazide: an open multicenter study in general practice (author's transl)]. 61
7031639 1981
36
Hypertension in childhood. 61
7344578 1981
37
Relationship between plasma catecholamines and urinary catecholamine excretion rates in normal subjects and certain diseased states. 61
7021996 1981
38
Interrelationship between the pathophysiology and antihypertensive treatment in benign essential hypertension. 61
7021899 1981
39
[Essential hypertension and diabetes]. 61
7010018 1981
40
The effect of renin and aldosterone inhibition by beta-adrenergic blockade on the response to the new diuretic azosemide. 61
6113965 1981
41
Metoprolol and propranolol in the treatment of essential hypertension - a long-term comparative study. 61
7027890 1981
42
Evaluation of the effect of indapamide on moderate benign essential hypertension complicated by airways obstruction. 61
7322957 1981
43
The kidney in benign essential hypertension. 61
7020668 1981
44
Evaluation of a spironolactone and althiazide combination (aldactacine) in Africans with benign essential hypertension. 61
7011783 1981
45
Increased 18-hydroxycorticosterone responses to frusemide in essential hypertension. 61
7428185 1980
46
A comparative evaluation of aldactide and methyldopa in the management of benign essential hypertension. 61
7216969 1980
47
Treatment of benign essential hypertension with frusemide in different doses. 61
7001489 1980
48
The use of a spironolactone and althiazide combination (aldactacine) in the treatment of benign essential hypertension. 61
6993252 1980
49
Renin-angiotensin-aldosterone system in arterial hypertension. 61
6995018 1980
50
Interrelationships between sodium clearance, plasma aldosterone, plasma renin activity, renal hemodynamics and blood pressure in renal disease. 61
397972 1979

Variations for Benign Essential Hypertension

Expression for Benign Essential Hypertension

Search GEO for disease gene expression data for Benign Essential Hypertension.

Pathways for Benign Essential Hypertension

Pathways related to Benign Essential Hypertension according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.03 PRL JAK2 INS
2
Show member pathways
10.61 POMC JAK2 CRP
3 10.1 PRL POMC INS

GO Terms for Benign Essential Hypertension

Cellular components related to Benign Essential Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 REN PRL POMC NAPSA INS CRP
2 secretory granule lumen GO:0034774 9.43 POMC OSTF1 INS
3 endosome lumen GO:0031904 9.33 PRL JAK2 INS
4 extracellular region GO:0005576 9.32 REN PRL POMC OSTF1 NAPSA INS

Biological processes related to Benign Essential Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 vasoconstriction GO:0042310 9.16 CRP AVP
2 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 8.96 PRL JAK2
3 cellular protein metabolic process GO:0044267 8.92 PRL NAPSA INS ALB

Molecular functions related to Benign Essential Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.46 REN POMC JAK2 AVP
2 insulin-like growth factor receptor binding GO:0005159 8.96 REN INS
3 hormone activity GO:0005179 8.92 PRL POMC INS AVP

Sources for Benign Essential Hypertension

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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