MCID: BNG021
MIFTS: 26

Benign Essential Hypertension

Categories: Blood diseases, Cardiovascular diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Benign Essential Hypertension

MalaCards integrated aliases for Benign Essential Hypertension:

Name: Benign Essential Hypertension 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10913
ICD9CM 35 401.1
NCIt 50 C3656
SNOMED-CT 68 1201005
UMLS 73 C0155583

Summaries for Benign Essential Hypertension

MalaCards based summary : Benign Essential Hypertension is related to hypertension, essential and kidney papillary necrosis. An important gene associated with Benign Essential Hypertension is REN (Renin), and among its related pathways/superpathways are Transport of vitamins, nucleosides, and related molecules and Renin secretion. Affiliated tissues include kidney, liver and pancreas, and related phenotype is renal/urinary system.

Related Diseases for Benign Essential Hypertension

Diseases in the Familial Hypertension family:

Hypertension, Essential Hypertension, Essential 1
Hypertension, Essential 2 Hypertension, Essential 3
Hypertension, Essential 4 Hypertension, Essential 5
Hypertension, Essential 6 Hypertension, Essential 7
Hypertension, Essential 8 Malignant Essential Hypertension
Malignant Hypertension Benign Essential Hypertension
Benign Secondary Hypertension Malignant Secondary Hypertension

Diseases related to Benign Essential Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
# Related Disease Score Top Affiliating Genes
1 hypertension, essential 10.6
2 kidney papillary necrosis 10.1 REN ALB
3 orthostatic proteinuria 10.1 REN ALB
4 anuria 10.1 REN ALB
5 hepatorenal syndrome 10.1 REN ALB
6 renal hypertension 10.1 REN ALB
7 hepatic vascular disease 10.1 ALB REN
8 acute kidney failure 10.1 ALB REN
9 interstitial nephritis 10.0 ALB REN
10 inappropriate adh syndrome 10.0 REN AVP
11 urinary tract obstruction 10.0 ALB REN
12 cardiac tamponade 10.0 REN AVP
13 ovarian hyperstimulation syndrome 10.0 ALB REN
14 obstructive nephropathy 10.0 ALB REN
15 obstructive jaundice 10.0 ALB REN
16 iga glomerulonephritis 10.0 ALB REN
17 syndrome of inappropriate antidiuretic hormone 10.0 AVP ALB
18 arteries, anomalies of 10.0 ALB REN
19 analbuminemia 10.0 AVP ALB
20 perinephritis 10.0 REN MGAM
21 diabetes insipidus 10.0 AVP REN
22 eclampsia 10.0 ALB REN
23 mineral metabolism disease 9.9 MGAM REN
24 glucose metabolism disease 9.9 ALB REN
25 pancreas disease 9.9 ALB AVP
26 acquired metabolic disease 9.9 ALB REN
27 seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance 9.9 AVP MGAM
28 urinary system disease 9.9 REN AVP ALB
29 autosomal dominant polycystic kidney disease 9.9 REN AVP ALB
30 liver cirrhosis 9.8 REN AVP ALB
31 cardiac arrest 9.8 ALB AVP
32 premenstrual tension 9.8 REN MGAM AVP
33 space motion sickness 9.7 REN MGAM AVP

Comorbidity relations with Benign Essential Hypertension via Phenotypic Disease Network (PDN): (show all 43)


Active Peptic Ulcer Disease Acute Cystitis
Anxiety Aortic Valve Disease 1
Basilar Artery Insufficiency Benign Hypertensive Renal Disease
Benign Renovascular Hypertension Bronchitis
Cerebral Atherosclerosis Cerebrovascular Disease
Chronic Kidney Failure Chronic Myocardial Ischemia
Deficiency Anemia Diabetic Polyneuropathy
Dressler's Syndrome Dysthymic Disorder
Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation Esophagitis
Familial Atrial Fibrillation First-Degree Atrioventricular Block
Generalized Atherosclerosis Gout
Heart Disease Hyperlipoproteinemia, Type V
Hypertensive Encephalopathy Hypoglycemia
Hypothyroidism Intermediate Coronary Syndrome
Intracranial Embolism Intracranial Thrombosis
Iron Deficiency Anemia Ischemic Heart Disease
Labyrinthitis Malignant Essential Hypertension
Microvascular Complications of Diabetes 1 Mitral Valve Disease
Osteoarthritis Osteoporosis
Peripheral Vascular Disease Right Bundle Branch Block
Sinoatrial Node Disease Transient Cerebral Ischemia
Vertebral Artery Insufficiency

Graphical network of the top 20 diseases related to Benign Essential Hypertension:



Diseases related to Benign Essential Hypertension

Symptoms & Phenotypes for Benign Essential Hypertension

MGI Mouse Phenotypes related to Benign Essential Hypertension:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 8.92 ALB AVP PPP3CA REN

Drugs & Therapeutics for Benign Essential Hypertension

Search Clinical Trials , NIH Clinical Center for Benign Essential Hypertension

Genetic Tests for Benign Essential Hypertension

Anatomical Context for Benign Essential Hypertension

MalaCards organs/tissues related to Benign Essential Hypertension:

41
Kidney, Liver, Pancreas

Publications for Benign Essential Hypertension

Articles related to Benign Essential Hypertension:

(show all 39)
# Title Authors Year
1
Clinical usefulness of a timed overnight (8 hours) Urine Albumin (microalbumin) excretion in monitor-ing treatment in benign essential hypertension. ( 25126874 )
2014
2
The heterogeneity of vascular findings in the kidneys of patients with benign essential hypertension. ( 10435870 )
1999
3
The role of Na,K-ATPase inhibitor on pressor responsiveness in patients with benign essential hypertension. ( 2157465 )
1990
4
Renal function in old age and uncomplicated benign essential hypertension. ( 6525640 )
1984
5
Experiences with Chlortalidone treatment in benign essential hypertension cases. ( 6546265 )
1984
6
Role of the aldosterone system in the salt-sensitivity of patients with benign essential hypertension. ( 6343666 )
1983
7
Indoramin as second step therapy in the management of benign essential hypertension. ( 6353433 )
1983
8
Plasma vasopressin and blood pressure. Studies in normal subjects and in benign essential hypertension at rest and after postural challenge. ( 6849715 )
1983
9
The kidney in benign essential hypertension. ( 7020668 )
1981
10
Interrelationship between the pathophysiology and antihypertensive treatment in benign essential hypertension. ( 7021899 )
1981
11
Evaluation of the effect of indapamide on moderate benign essential hypertension complicated by airways obstruction. ( 7322957 )
1981
12
Evaluation of a spironolactone and althiazide combination (aldactacine) in Africans with benign essential hypertension. ( 7011783 )
1981
13
The use of a spironolactone and althiazide combination (aldactacine) in the treatment of benign essential hypertension. ( 6993252 )
1980
14
A comparative evaluation of aldactide and methyldopa in the management of benign essential hypertension. ( 7216969 )
1980
15
Treatment of benign essential hypertension with frusemide in different doses. ( 7001489 )
1980
16
Glomerular lesions in benign essential hypertension. A study of eight biopsy specimens with laboratory evidence suggestive of glomerular abnormalities. ( 581847 )
1979
17
Increased plasma adrenaline concentrations in benign essential hypertension. ( 589124 )
1977
18
Interrelations among blood pressure, blood volume, plasma renin activity and urinary catecholamines in benign essential hypertension. ( 835600 )
1977
19
Beta adrenergic blockade and diuretic therapy in benign essential hypertension: A dynamic assessment. ( 3963 )
1976
20
Hypotensive response to angiotensin II analogue in benign essential hypertension. ( 966373 )
1976
21
Dynamic aldosterone and 18-hydroxydeoxycorticosterone studies in labile and stable benign essential hypertension. ( 171513 )
1975
22
Treatment of benign essential hypertension: comparison of furosemide and hydrochlorothiazide. ( 786684 )
1975
23
Metabolism of pregnenolone and pregnenolone sulphate in benign essential hypertension. ( 4461269 )
1974
24
Increased urinary albumin-excretion rate in benign essential hypertension. ( 4134681 )
1974
25
Primary aldosteronism, idiopathic aldosteronism and "low-renin" benign essential hypertension. A retrospective study. ( 4465731 )
1974
26
Editorial: New knowledge of benign essential hypertension. ( 4355134 )
1973
27
Plasma progesterone in normal subjects and patients with benign essential hypertension on normal, low, and high sodium intake. ( 5012771 )
1972
28
Systemic and renal haemodynamics, body fluids and renin in benign essential hypertension with special reference to natural history. ( 5027237 )
1972
29
A decreased metabolic clearance rate of aldosterone in benign essential hypertension. ( 5116208 )
1971
30
Secretion rate of dehydroepiandrosterone and dehydroepiandrosterone sulfate in benign essential hypertension as compared to normal subjects. ( 4251990 )
1970
31
How to treat benign essential hypertension. ( 5648395 )
1968
32
Renin release in patients with benign essential hypertension. ( 5666849 )
1968
33
Treatment of benign essential hypertension. ( 5904580 )
1966
34
Fine morphology of human juxtaglomerular cells in patients with benign essential hypertension. ( 5960462 )
1966
35
THE TREATMENT OF BENIGN ESSENTIAL HYPERTENSION. ( 14157065 )
1964
36
Adrenal cortical function in benign essential hypertension. ( 13996810 )
1963
37
Benign essential hypertension: follow-up of 100 patients under observation for from 18 to 34 years. ( 13259331 )
1955
38
Longevity in benign essential hypertension. ( 14945948 )
1952
39
The prognosis in benign essential hypertension. ( 13000912 )
1952

Variations for Benign Essential Hypertension

Expression for Benign Essential Hypertension

Search GEO for disease gene expression data for Benign Essential Hypertension.

Pathways for Benign Essential Hypertension

Pathways related to Benign Essential Hypertension according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
2 10.44 PPP3CA REN

GO Terms for Benign Essential Hypertension

Biological processes related to Benign Essential Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to drug GO:0035690 8.62 PPP3CA REN

Molecular functions related to Benign Essential Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 drug binding GO:0008144 8.62 ALB PPP3CA

Sources for Benign Essential Hypertension

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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