MCID: BNG017
MIFTS: 32

Benign Fibrous Mesothelioma

Categories: Cancer diseases

Aliases & Classifications for Benign Fibrous Mesothelioma

MalaCards integrated aliases for Benign Fibrous Mesothelioma:

Name: Benign Fibrous Mesothelioma 12 15 17
Localized Benign Fibrous Mesothelioma 12
Solitary Fibrous Tumor, Pleural 44
Pleural Solitary Fibrous Tumor 70
Fibrous Mesothelioma, Benign 12
Solitary Fibrous Tumor 70

Classifications:



External Ids:

Disease Ontology 12 DOID:2653
MeSH 44 D054363
NCIt 50 C4457
SNOMED-CT 67 15702005
UMLS 70 C0334511 C1266119

Summaries for Benign Fibrous Mesothelioma

MalaCards based summary : Benign Fibrous Mesothelioma, also known as localized benign fibrous mesothelioma, is related to benign pleural mesothelioma and gastrointestinal stromal tumor. An important gene associated with Benign Fibrous Mesothelioma is CD34 (CD34 Molecule), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. The drugs Axitinib and Trabectedin have been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and lung, and related phenotypes are integument and neoplasm

Wikipedia : 73 Solitary fibrous tumor (SFT), also known as fibrous tumor of the pleura, is a rare mesenchymal tumor... more...

Related Diseases for Benign Fibrous Mesothelioma

Diseases related to Benign Fibrous Mesothelioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 152)
# Related Disease Score Top Affiliating Genes
1 benign pleural mesothelioma 30.2 STAT6 CD34
2 gastrointestinal stromal tumor 29.5 KIT IGF2 CD34
3 benign mesothelioma 10.7
4 fibroma 10.2 CD34 CALB2
5 pacinian tumor 10.2 CD34 CALB2
6 peritoneal benign neoplasm 10.2 CD34 CALB2
7 testicular fibroma 10.2 CD34 CALB2
8 lung sarcoma 10.2 CD34 CALB2
9 epithelioid cell synovial sarcoma 10.2 CD34 CALB2
10 benign peritoneal mesothelioma 10.2 CD34 CALB2
11 monophasic synovial sarcoma 10.2 CD34 CALB2
12 pilar sheath acanthoma 10.2 CD34 CALB2
13 cystic lymphangioma 10.2 CD34 CALB2
14 glomus tumor 10.2 CD34 CALB2
15 secondary hypertrophic osteoarthropathy 10.2 IGF2 CD34
16 mesothelioma, malignant 10.1
17 potter's syndrome 10.1 IGF2 CD34
18 reproductive organ benign neoplasm 10.1 CD34 CALB2
19 epithelioid sarcoma 10.1 CD34 CALB2
20 inflammatory liposarcoma 10.1 CD34 ALK
21 intravascular fasciitis 10.1 CD34 ALK
22 lung sarcomatoid carcinoma 10.1 CALB2 ALK
23 pediatric fibrosarcoma 10.1 CD34 ALK
24 fetal alcohol syndrome 10.1 IGF2 CALB2
25 paratesticular lipoma 10.1 ALK ACTA1
26 lipoma of spermatic cord 10.1 ALK ACTA1
27 urethra clear cell adenocarcinoma 10.1 CALB2 ALK
28 peritoneal mesothelioma 10.1 CALB2 ALK
29 carbapenem allergy 10.0 STAT6 ALK
30 severe combined immunodeficiency, x-linked 10.0 STAT6 CD34
31 spinal cord sarcoma 10.0 KIT CD34
32 gallbladder leiomyoma 10.0 KIT CD34
33 small intestine leiomyosarcoma 10.0 KIT CD34
34 neuronal intestinal dysplasia, type b 10.0 KIT CD34
35 mucocele of appendix 10.0 KIT CD34
36 gallbladder leiomyosarcoma 10.0 KIT CD34
37 deep leiomyoma 10.0 KIT CD34
38 pericardial effusion 10.0 CD34 ALK
39 angiomyoma 10.0 KIT CD34
40 retroperitoneal hemangiopericytoma 10.0 KIT CD34
41 breast leiomyosarcoma 10.0 KIT CD34
42 malignant pleural mesothelioma 10.0
43 rare tumor 10.0
44 colon leiomyosarcoma 10.0 KIT CD34
45 jejunal neoplasm 10.0 KIT CD34
46 benign perivascular tumor 10.0 KIT CD34
47 perivascular tumor 10.0 KIT CD34
48 plexiform schwannoma 10.0 KIT CD34
49 small intestine leiomyoma 10.0 KIT CD34
50 retroperitoneal leiomyosarcoma 10.0 KIT CD34

Graphical network of the top 20 diseases related to Benign Fibrous Mesothelioma:



Diseases related to Benign Fibrous Mesothelioma

Symptoms & Phenotypes for Benign Fibrous Mesothelioma

MGI Mouse Phenotypes related to Benign Fibrous Mesothelioma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.55 ALK CD34 IGF2 KIT STAT6
2 neoplasm MP:0002006 9.26 ALK CD34 KIT STAT6
3 vision/eye MP:0005391 9.02 ACTA1 ALK IGF2 KIT STAT6

Drugs & Therapeutics for Benign Fibrous Mesothelioma

Drugs for Benign Fibrous Mesothelioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Axitinib Approved, Investigational Phase 2 319460-85-0 6450551
2
Trabectedin Approved, Investigational Phase 2 114899-77-3 108150
3
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
4
Dacarbazine Approved, Investigational Phase 2 4342-03-4 5351166 2942
5 Protein Kinase Inhibitors Phase 2
6
Liposomal doxorubicin Phase 2 31703
7 Antibiotics, Antitubercular Phase 2
8 Alkylating Agents Phase 2
9 Anti-Bacterial Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Study on Axitinib in Advanced VEGFR and/or PDGFR Solitary Fibrous Tumor Unknown status NCT02261207 Phase 2 Axitinib
2 A Phase 1/2, Open-Label, Safety, Tolerability, Pharmacokinetics, and Anti-Tumor Activity Study of Repotrectinib in Pediatric and Young Adult Subjects With Advanced or Metastatic Malignancies Harboring ALK, ROS1, NTRK1-3 Alterations Recruiting NCT04094610 Phase 1, Phase 2 Oral repotrectinib (TPX-0005)
3 ERibulin in Advanced Solitary Fibrous Tumor, an ItaliaN Sarcoma Group Phase II Study (ERASING) Recruiting NCT03840772 Phase 2 Eribulin
4 Solitary Fibrous Tumor: Phase II Study on Trabectedin Versus Adriamycin Plus Dacarbazine in Advanced Patients Recruiting NCT03023124 Phase 2 Trabectedin;Adriamycin;Dacarbazine
5 A Phase II Open-Label Trial of Pazopanib Administered as a Single Agent in Patients With Unresectable or Metastatic Solitary Fibrous Tumor (SFT) and Extraskeletal Myxoid Chondrosarcoma (EMC) Active, not recruiting NCT02066285 Phase 2 Pazopanib
6 Epidemiology and Outcome of Solitary Fibrous Tumors of the Pleura. A Multicenter Study. Unknown status NCT01694654
7 Chemotherapy Followed by Surgery and Neoadjuvant Hemothoracic Intensity Modified Radiation Therapy (IMRT) for Patients With Malignant Pleural Mesothelioma Recruiting NCT02613312
8 Staging Procedures to Diagnose Malignant Pleural Mesothelioma Recruiting NCT02648763
9 Surgery for Mesothelioma After Radiation Therapy "SMART" for Resectable Malignant Pleural Mesothelioma Recruiting NCT02613299

Search NIH Clinical Center for Benign Fibrous Mesothelioma

Cochrane evidence based reviews: solitary fibrous tumor, pleural

Genetic Tests for Benign Fibrous Mesothelioma

Anatomical Context for Benign Fibrous Mesothelioma

MalaCards organs/tissues related to Benign Fibrous Mesothelioma:

40
Small Intestine, Liver, Lung, Breast, Thymus, Heart, Colon

Publications for Benign Fibrous Mesothelioma

Articles related to Benign Fibrous Mesothelioma:

(show all 27)
# Title Authors PMID Year
1
Solitary benign fibrous mesothelioma of the peritoneum: A rare entity in a 2-year-old child. 61
26723236 2016
2
A case of solitary fibrous tumour of the nose and paranasal sinuses. 61
23120332 2006
3
[Pleural benign fibrous mesothelioma versus pleural benign solitary tumor]. 61
11766292 2001
4
[Benign fibrous mesothelioma]. 61
10216749 1999
5
Localized fibrous tumours of the pleura: 15 new cases and review of the literature. 61
9860200 1998
6
[Benign fibrous mesothelioma: report of 8 cases]. 61
9762399 1998
7
Localized benign fibrous mesothelioma mimicking a malignant tumor of the pleura. 61
10547262 1998
8
Pictorial essay: solitary fibrous tumor of the pleura. 61
9440836 1998
9
Benign fibrous mesothelioma successfully treated by thoracoscope-assisted surgery: report of a case. 61
9786587 1998
10
Benign fibrous mesothelioma of the pleura: MR study and pathologic correlation. 61
8798015 1996
11
Benign fibrous mesothelioma of the pleura: MR imaging findings. 61
7572492 1995
12
Benign fibrous mesothelioma: report of a case. 61
8669882 1995
13
[A recurrence of benign fibrous mesothelioma of the pleura: a case report]. 61
7564048 1995
14
[Benign fibrous mesothelioma of the pleura]. 61
7746454 1994
15
Pleural and pericardial mesothelioma in a general teaching hospital during the last fourteen years. 61
7954042 1994
16
[Benign fibrous mesothelioma of the pleura]. 61
8266292 1993
17
[Reexpansion pulmonary edema after removal of a huge localized mesothelioma]. 61
8360541 1993
18
Benign fibrous mesothelioma of the pleura: MR findings. 61
8416626 1993
19
CT findings in benign fibrous mesothelioma of the pleura: pathologic correlation in nine patients. 61
1566702 1992
20
[Large benign fibrous mesothelioma of the pleura]. 61
2617790 1989
21
Diffuse malignant pleural mesothelioma in an urban hospital: clinical spectrum and trend in incidence over time. 61
2610210 1989
22
[Hypertrophic osteoarthropathy secondary to benign fibrous mesothelioma]. 61
4012679 1985
23
[Benign fibrous mesothelioma with articular manifestations and digital clubbing]. 61
7098681 1982
24
Resection of giant benign fibrous mesothelioma of pleura. 61
6928541 1980
25
Benign fibrous mesothelioma: a report of ten cases. 61
689930 1978
26
[Case of localized benign fibrous mesothelioma originating at the pulmonary pleura]. 61
557686 1977
27
Recurrent benign fibrous mesothelioma of the pleura. 61
4696883 1973

Variations for Benign Fibrous Mesothelioma

Expression for Benign Fibrous Mesothelioma

Search GEO for disease gene expression data for Benign Fibrous Mesothelioma.

Pathways for Benign Fibrous Mesothelioma

Pathways related to Benign Fibrous Mesothelioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.33 STAT6 KIT IGF2 ALK ACTA1
2
Show member pathways
13.03 STAT6 KIT IGF2 ALK ACTA1
3
Show member pathways
12.78 KIT IGF2 ALK ACTA1
4
Show member pathways
12.7 STAT6 KIT IGF2 ALK ACTA1
5 12.01 STAT6 KIT CD34
6 11.98 STAT6 KIT IGF2 ALK
7
Show member pathways
11.22 KIT IGF2 ALK ACTA1
8 11.13 KIT IGF2
9 11.05 KIT ALK

GO Terms for Benign Fibrous Mesothelioma

Biological processes related to Benign Fibrous Mesothelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hemopoiesis GO:0030097 8.96 KIT CD34
2 regulation of cell proliferation GO:0042127 8.8 STAT6 KIT ALK

Molecular functions related to Benign Fibrous Mesothelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.62 KIT ALK

Sources for Benign Fibrous Mesothelioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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