MCID: BNG025
MIFTS: 25

Benign Mammary Dysplasia

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Benign Mammary Dysplasia

MalaCards integrated aliases for Benign Mammary Dysplasia:

Name: Benign Mammary Dysplasia 12 15 70 32

Classifications:



External Ids:

Disease Ontology 12 DOID:9504
ICD9CM 34 610.8
ICD10 32 N60 N60.9
UMLS 70 C0156319 C1305934

Summaries for Benign Mammary Dysplasia

Disease Ontology : 12 A breast benign neoplasm that encompasses a range of conditions in which there is marked change in the breast tissue.

MalaCards based summary : Benign Mammary Dysplasia is related to solitary cyst of breast and breast cyst. An important gene associated with Benign Mammary Dysplasia is RHBDD2 (Rhomboid Domain Containing 2), and among its related pathways/superpathways are Protein processing in endoplasmic reticulum and Integrated Breast Cancer Pathway. Affiliated tissues include breast, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 73 Fibrocystic breast changes is a condition of the breasts where there may be pain, breast cysts, and... more...

Related Diseases for Benign Mammary Dysplasia

Diseases related to Benign Mammary Dysplasia via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 solitary cyst of breast 10.2
2 breast cyst 10.2
3 breast fibroadenosis 10.2
4 fibrosclerosis of breast 10.2
5 absolute glaucoma 9.8 BCL2 BAK1
6 central pontine myelinolysis 9.8 BCL2 BAK1
7 retinal ischemia 9.7 BCL2 BAK1

Graphical network of the top 20 diseases related to Benign Mammary Dysplasia:



Diseases related to Benign Mammary Dysplasia

Symptoms & Phenotypes for Benign Mammary Dysplasia

GenomeRNAi Phenotypes related to Benign Mammary Dysplasia according to GeneCards Suite gene sharing:

26 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-106 9.58 BCL2 RHBDL1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-125 9.58 RHBDL1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-134 9.58 BCL2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-159 9.58 BCL2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.58 BCL2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.58 BCL2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.58 BCL2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.58 BCL2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-215 9.58 RHBDL1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-37 9.58 BCL2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-59 9.58 BCL2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-68 9.58 BCL2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.58 BCL2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-77 9.58 BCL2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.58 BCL2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-95 9.58 RHBDL1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-96 9.58 BCL2

Drugs & Therapeutics for Benign Mammary Dysplasia

Search Clinical Trials , NIH Clinical Center for Benign Mammary Dysplasia

Genetic Tests for Benign Mammary Dysplasia

Anatomical Context for Benign Mammary Dysplasia

MalaCards organs/tissues related to Benign Mammary Dysplasia:

40
Breast

Publications for Benign Mammary Dysplasia

Articles related to Benign Mammary Dysplasia:

(show all 24)
# Title Authors PMID Year
1
Age peculiarities of reproductive morbidity in female participants of the ChNPP accident consequences clean up (according to the figures from SRU, 1988-2012 survey period). 61
26695915 2015
2
Expression of the apoptotic markers in normal breast epithelium, benign mammary dysplasia and in breast cancer. 61
15478112 2004
3
[The clinical picture of latent hypothyroidism in women]. 61
8686203 1996
4
[Latent hypothyroidism--a minor laboratory variation or a disease?]. 61
7552383 1995
5
Incidence estimation of female breast cancer among Koreans. 61
7848581 1994
6
Mastalgia. 61
1867598 1991
7
Cytodiagnosis and other methods of biopsy in the modern management of breast cancer. 61
2657973 1989
8
The treatment of symptomatic benign breast disease with danazol. 61
3074777 1988
9
The complementary role of fine needle aspiration cytology and Tru-cut needle biopsy in the management of breast masses. 61
3689249 1987
10
Fibro-adenoma of the breast. 61
4041718 1985
11
Breast disease in young women. When is biopsy indicated? 61
6877161 1983
12
The comparative epidemiology of benign breast lumps and breast cancer in Western Australia. 61
7129671 1982
13
Breast tumors in patients with hyperprolactinemia. 61
7200826 1982
14
Benign mammary dysplasia. 61
514166 1979
15
Benign mammary dysplasia. 61
514167 1979
16
Modern management of benign mammary dysplasia. 61
470733 1979
17
Aspiration biopsy cytology in proliferating benign mammary dysplasia. 61
277037 1978
18
The possible relationship between mammary dysplasia and breast cancer. 61
1071558 1976
19
The xeroradiographic appearances of some uncommon malignant mammary neoplasms. 61
187368 1976
20
Inflammatory damage to ducts in mammary dysplasia: a cause of duct obliteration. 61
1238515 1975
21
Periductal foam cells in benign mammary dysplasia. 61
1195061 1975
22
Fibrocystic disease of the breast (benign mammary dysplasia). 61
1165420 1975
23
Neural invasion in benign mammary dysplasia. 61
4719773 1973
24
Benign mammary dysplasia. 61
5073961 1972

Variations for Benign Mammary Dysplasia

Expression for Benign Mammary Dysplasia

Search GEO for disease gene expression data for Benign Mammary Dysplasia.

Pathways for Benign Mammary Dysplasia

Pathways related to Benign Mammary Dysplasia according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1 11.74 BCL2 BAK1
2 11.68 BCL2 BAK1
3 11.6 BCL2 BAK1
4
Show member pathways
11.55 BCL2 BAK1
5 11.49 BCL2 BAK1
6 11.37 BCL2 BAK1
7
Show member pathways
11.29 BCL2 BAK1
8 11.18 BCL2 BAK1
9 10.86 BCL2 BAK1
10
Show member pathways
10.81 BCL2 BAK1
11 10.32 BCL2 BAK1

GO Terms for Benign Mammary Dysplasia

Cellular components related to Benign Mammary Dysplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial membrane GO:0031966 8.96 BCL2 BAK1
2 pore complex GO:0046930 8.62 BCL2 BAK1

Biological processes related to Benign Mammary Dysplasia according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 regulation of cell cycle GO:0051726 9.52 BCL2 BAK1
2 cell proliferation GO:0008283 9.51 BCL2 BAK1
3 response to hydrogen peroxide GO:0042542 9.49 BCL2 BAK1
4 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.48 BCL2 BAK1
5 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 9.46 BCL2 BAK1
6 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.43 BCL2 BAK1
7 regulation of mitochondrial membrane potential GO:0051881 9.4 BCL2 BAK1
8 response to gamma radiation GO:0010332 9.37 BCL2 BAK1
9 release of cytochrome c from mitochondria GO:0001836 9.32 BCL2 BAK1
10 B cell homeostasis GO:0001782 9.26 BCL2 BAK1
11 endoplasmic reticulum calcium ion homeostasis GO:0032469 9.16 BCL2 BAK1
12 regulation of mitochondrial membrane permeability GO:0046902 8.96 BCL2 BAK1
13 leukocyte homeostasis GO:0001776 8.62 BCL2 BAK1

Molecular functions related to Benign Mammary Dysplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type peptidase activity GO:0008236 8.96 RHBDL3 RHBDL1
2 serine-type endopeptidase activity GO:0004252 8.8 RHBDL3 RHBDL1 RHBDD2

Sources for Benign Mammary Dysplasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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