MCID: BNG004
MIFTS: 20

Benign Mastocytoma

Categories: Cancer diseases

Aliases & Classifications for Benign Mastocytoma

MalaCards integrated aliases for Benign Mastocytoma:

Name: Benign Mastocytoma 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:4658
NCIt 50 C9303
SNOMED-CT 67 134333006
ICD10 32 D47.09
UMLS 71 C0024897 C2242987

Summaries for Benign Mastocytoma

MalaCards based summary : Benign Mastocytoma is related to extracutaneous mastocytoma and mast cell neoplasm. An important gene associated with Benign Mastocytoma is CD2 (CD2 Molecule), and among its related pathways/superpathways are PAK Pathway and NF-kappaB Signaling. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Benign Mastocytoma

Diseases related to Benign Mastocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 extracutaneous mastocytoma 31.4 KIT CD2
2 mast cell neoplasm 31.3 KIT CD2
3 reticulum cell sarcoma 10.0 PTPRC CD2
4 gallbladder lymphoma 10.0 PTPRC CD2
5 small intestinal sarcoma 9.9 PTPRC KIT
6 endometrial small cell carcinoma 9.9 PTPRC KIT
7 small cell carcinoma 9.9 PTPRC KIT
8 glomangiomatosis 9.9 PTPRC KIT
9 mediastinal cancer 9.8 PTPRC KIT
10 conventional fibrosarcoma 9.8 PTPRC KIT
11 retroperitoneum carcinoma 9.8 PTPRC KIT
12 myeloid sarcoma 9.8 PTPRC KIT
13 thymus gland disease 9.8 PTPRC KIT
14 thymus cancer 9.8 PTPRC KIT
15 thymic carcinoma 9.8 PTPRC KIT
16 cutaneous solitary mastocytoma 9.8 KIT CD2
17 sm-ahnmd 9.8 KIT CD2
18 mast-cell sarcoma 9.8 KIT CD2
19 nasal cavity benign neoplasm 9.8 KIT CD2
20 malignant fibrous histiocytoma 9.8 PTPRC KIT
21 indolent systemic mastocytosis 9.8 KIT CD2
22 merkel cell carcinoma 9.8 PTPRC KIT
23 systemic mastocytosis 9.8 KIT CD2
24 mastocytosis 9.8 KIT CD2
25 neuroendocrine carcinoma 9.8 PTPRC KIT
26 small cell cancer of the lung 9.8 PTPRC KIT
27 leukocyte disease 9.8 PTPRC KIT
28 b-lymphoblastic leukemia/lymphoma 9.8 PTPRC KIT
29 aggressive systemic mastocytosis 9.8 KIT CD2
30 mastocytosis, cutaneous 9.7 KIT CD2
31 bone marrow cancer 9.7 PTPRC KIT
32 blood platelet disease 9.7 PTPRC KIT
33 integumentary system disease 9.7 PTPRC KIT
34 blood coagulation disease 9.7 PTPRC KIT
35 mantle cell lymphoma 9.6 PTPRC KIT
36 pancytopenia 9.6 KIT CD2
37 severe combined immunodeficiency 9.6 PTPRC KIT
38 thymoma 9.5 PTPRC KIT CD2
39 leber plus disease 9.5 PTPRC KIT CD2
40 leukemia, acute lymphoblastic 9.5 PTPRC KIT CD2
41 ewing sarcoma 9.5 PTPRC KIT
42 leukemia, acute myeloid 9.5 PTPRC KIT CD2

Graphical network of the top 20 diseases related to Benign Mastocytoma:



Diseases related to Benign Mastocytoma

Symptoms & Phenotypes for Benign Mastocytoma

GenomeRNAi Phenotypes related to Benign Mastocytoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-102 9.23 KIT
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-105 9.23 PTPRC
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.23 KIT PTPRC
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.23 KIT
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-41 9.23 PTPRC
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-42 9.23 KIT
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.23 PTPRC

Drugs & Therapeutics for Benign Mastocytoma

Search Clinical Trials , NIH Clinical Center for Benign Mastocytoma

Genetic Tests for Benign Mastocytoma

Anatomical Context for Benign Mastocytoma

Publications for Benign Mastocytoma

Articles related to Benign Mastocytoma:

# Title Authors PMID Year
1
Diagnostic criteria and classification of mastocytosis: a consensus proposal. 61
11377686 2001
2
Tissue mast cells in health and disease. 61
2582403 1985

Variations for Benign Mastocytoma

Expression for Benign Mastocytoma

Search GEO for disease gene expression data for Benign Mastocytoma.

Pathways for Benign Mastocytoma

Pathways related to Benign Mastocytoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.65 PTPRC KIT CD2
2 11.65 PTPRC KIT CD2
3 11.61 PTPRC CD2
4 11.36 KIT CD2
5 11.3 PTPRC KIT
6 11.16 PTPRC KIT
7 11.02 PTPRC KIT
8 10.86 PTPRC KIT CD2

GO Terms for Benign Mastocytoma

Cellular components related to Benign Mastocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.5 PTPRC KIT CD2
2 membrane raft GO:0045121 9.37 PTPRC CD2
3 cell surface GO:0009986 9.33 PTPRC KIT CD2
4 cell-cell junction GO:0005911 9.26 KIT CD2
5 external side of plasma membrane GO:0009897 9.13 PTPRC KIT CD2
6 cytoplasmic side of plasma membrane GO:0009898 8.8 PTPRC KIT CD2

Biological processes related to Benign Mastocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 activation of MAPK activity GO:0000187 9.43 PTPRC KIT
2 positive regulation of MAPK cascade GO:0043410 9.4 PTPRC KIT
3 positive regulation of tumor necrosis factor production GO:0032760 9.37 PTPRC CD2
4 B cell differentiation GO:0030183 9.32 PTPRC KIT
5 hematopoietic progenitor cell differentiation GO:0002244 9.26 PTPRC KIT
6 T cell activation GO:0042110 9.16 PTPRC CD2
7 T cell differentiation GO:0030217 8.96 PTPRC KIT
8 heterotypic cell-cell adhesion GO:0034113 8.62 PTPRC CD2

Sources for Benign Mastocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....