Benign Mastocytoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Benign Mastocytoma

MalaCards integrated aliases for Benign Mastocytoma:

Name: Benign Mastocytoma ¹² ¹⁵ ⁷¹

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4658

NCIt ⁵⁰ C9303

SNOMED-CT ⁶⁷ 134333006

ICD10 ³² D47.09

UMLS ⁷¹ C0024897 C2242987

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Summaries for Benign Mastocytoma

MalaCards based summary : Benign Mastocytoma is related to extracutaneous mastocytoma and mast cell neoplasm. An important gene associated with Benign Mastocytoma is CD2 (CD2 Molecule), and among its related pathways/superpathways are PAK Pathway and NF-kappaB Signaling. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

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Related Diseases for Benign Mastocytoma

Diseases related to Benign Mastocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)

#	Related Disease	Score	Top Affiliating Genes
1	extracutaneous mastocytoma	31.4	KIT CD2
2	mast cell neoplasm	31.3	KIT CD2
3	reticulum cell sarcoma	10.0	PTPRC CD2
4	gallbladder lymphoma	10.0	PTPRC CD2
5	small intestinal sarcoma	9.9	PTPRC KIT
6	endometrial small cell carcinoma	9.9	PTPRC KIT
7	small cell carcinoma	9.9	PTPRC KIT
8	glomangiomatosis	9.9	PTPRC KIT
9	mediastinal cancer	9.8	PTPRC KIT
10	conventional fibrosarcoma	9.8	PTPRC KIT
11	retroperitoneum carcinoma	9.8	PTPRC KIT
12	myeloid sarcoma	9.8	PTPRC KIT
13	thymus gland disease	9.8	PTPRC KIT
14	thymus cancer	9.8	PTPRC KIT
15	thymic carcinoma	9.8	PTPRC KIT
16	cutaneous solitary mastocytoma	9.8	KIT CD2
17	sm-ahnmd	9.8	KIT CD2
18	mast-cell sarcoma	9.8	KIT CD2
19	nasal cavity benign neoplasm	9.8	KIT CD2
20	malignant fibrous histiocytoma	9.8	PTPRC KIT
21	indolent systemic mastocytosis	9.8	KIT CD2
22	merkel cell carcinoma	9.8	PTPRC KIT
23	systemic mastocytosis	9.8	KIT CD2
24	mastocytosis	9.8	KIT CD2
25	neuroendocrine carcinoma	9.8	PTPRC KIT
26	small cell cancer of the lung	9.8	PTPRC KIT
27	leukocyte disease	9.8	PTPRC KIT
28	b-lymphoblastic leukemia/lymphoma	9.8	PTPRC KIT
29	aggressive systemic mastocytosis	9.8	KIT CD2
30	mastocytosis, cutaneous	9.7	KIT CD2
31	bone marrow cancer	9.7	PTPRC KIT
32	blood platelet disease	9.7	PTPRC KIT
33	integumentary system disease	9.7	PTPRC KIT
34	blood coagulation disease	9.7	PTPRC KIT
35	mantle cell lymphoma	9.6	PTPRC KIT
36	pancytopenia	9.6	KIT CD2
37	severe combined immunodeficiency	9.6	PTPRC KIT
38	thymoma	9.5	PTPRC KIT CD2
39	leber plus disease	9.5	PTPRC KIT CD2
40	leukemia, acute lymphoblastic	9.5	PTPRC KIT CD2
41	ewing sarcoma	9.5	PTPRC KIT
42	leukemia, acute myeloid	9.5	PTPRC KIT CD2

Graphical network of the top 20 diseases related to Benign Mastocytoma:

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Symptoms & Phenotypes for Benign Mastocytoma

GenomeRNAi Phenotypes related to Benign Mastocytoma according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased shRNA abundance (Z-score < -2)	GR00366-A-102	9.23	KIT
2	Decreased shRNA abundance (Z-score < -2)	GR00366-A-105	9.23	PTPRC
3	Decreased shRNA abundance (Z-score < -2)	GR00366-A-165	9.23	KIT PTPRC
4	Decreased shRNA abundance (Z-score < -2)	GR00366-A-18	9.23	KIT
5	Decreased shRNA abundance (Z-score < -2)	GR00366-A-41	9.23	PTPRC
6	Decreased shRNA abundance (Z-score < -2)	GR00366-A-42	9.23	KIT
7	Decreased shRNA abundance (Z-score < -2)	GR00366-A-68	9.23	PTPRC

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Drugs & Therapeutics for Benign Mastocytoma

Search Clinical Trials , NIH Clinical Center for Benign Mastocytoma

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Genetic Tests for Benign Mastocytoma

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Anatomical Context for Benign Mastocytoma

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Publications for Benign Mastocytoma

Articles related to Benign Mastocytoma:

#	Title	Authors	PMID	Year
1	Diagnostic criteria and classification of mastocytosis: a consensus proposal. ⁶¹	Valent P...Bennett JM	11377686	2001
2	Tissue mast cells in health and disease. ⁶¹	Parwaresch MR...Lennert K	2582403	1985

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Genes for Benign Mastocytoma

Genes related to Benign Mastocytoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CD2	CD2 Molecule	Protein Coding	4.82	DISEASES inferred ¹⁵
2	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	3.95	DISEASES inferred ¹⁵
3	PTPRC	Protein Tyrosine Phosphatase Receptor Type C	Protein Coding	3.95	DISEASES inferred ¹⁵

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Variations for Benign Mastocytoma

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Expression for Benign Mastocytoma

Search GEO for disease gene expression data for Benign Mastocytoma.

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Pathways for Benign Mastocytoma

Pathways related to Benign Mastocytoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	PAK Pathway ⁶³ Show member pathways Antioxidant Action of Vitamin-C ⁶³ Epithelial Adherens Junctions ⁶³	12.65	PTPRC KIT CD2
2	NF-kappaB Signaling ⁴	11.65	PTPRC KIT CD2
3	Cell adhesion molecules ³⁶	11.61	PTPRC CD2
4	Hematopoietic cell lineage ³⁶	11.36	KIT CD2
5	Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.3	PTPRC KIT
6	Innate Lymphoid Cell Differentiation Pathways ⁶⁴	11.16	PTPRC KIT
7	Dendritic Cells Developmental Lineage Pathway ⁶⁴	11.02	PTPRC KIT
8	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	10.86	PTPRC KIT CD2

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GO Terms for Benign Mastocytoma

Cellular components related to Benign Mastocytoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	integral component of plasma membrane	GO:0005887	9.5	PTPRC KIT CD2
2	membrane raft	GO:0045121	9.37	PTPRC CD2
3	cell surface	GO:0009986	9.33	PTPRC KIT CD2
4	cell-cell junction	GO:0005911	9.26	KIT CD2
5	external side of plasma membrane	GO:0009897	9.13	PTPRC KIT CD2
6	cytoplasmic side of plasma membrane	GO:0009898	8.8	PTPRC KIT CD2

Biological processes related to Benign Mastocytoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	activation of MAPK activity	GO:0000187	9.43	PTPRC KIT
2	positive regulation of MAPK cascade	GO:0043410	9.4	PTPRC KIT
3	positive regulation of tumor necrosis factor production	GO:0032760	9.37	PTPRC CD2
4	B cell differentiation	GO:0030183	9.32	PTPRC KIT
5	hematopoietic progenitor cell differentiation	GO:0002244	9.26	PTPRC KIT
6	T cell activation	GO:0042110	9.16	PTPRC CD2
7	T cell differentiation	GO:0030217	8.96	PTPRC KIT
8	heterotypic cell-cell adhesion	GO:0034113	8.62	PTPRC CD2

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Sources for Benign Mastocytoma

¹ BioSystems

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⁴⁰ MalaCards

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⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

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⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia