Benign Mastocytoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Benign Mastocytoma

MalaCards integrated aliases for Benign Mastocytoma:

Name: Benign Mastocytoma ¹² ¹⁵ ⁷¹

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4658

NCIt ⁴⁹ C9303

SNOMED-CT ⁶⁷ 404171008 89796001

ICD10 ³² D47.09

UMLS ⁷¹ C0024897 C2242987

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Summaries for Benign Mastocytoma

MalaCards based summary : Benign Mastocytoma is related to extracutaneous mastocytoma and mast cell neoplasm. An important gene associated with Benign Mastocytoma is CLEC11A (C-Type Lectin Domain Containing 11A), and among its related pathways/superpathways are Akt Signaling and PAK Pathway.

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Related Diseases for Benign Mastocytoma

Diseases related to Benign Mastocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)

#	Related Disease	Score	Top Affiliating Genes
1	extracutaneous mastocytoma	32.0	KIT CD2
2	mast cell neoplasm	32.0	KIT CD2
3	esophagus sarcoma	10.1	NAAA KIT
4	hydrops of gallbladder	10.1	NAAA CD40LG
5	piebald trait	10.1	KIT CLEC11A
6	intussusception	10.0	KIT CD40LG
7	exanthem	10.0	KIT CD40LG
8	mast-cell sarcoma	10.0	KIT CD2
9	sm-ahnmd	10.0	KIT CD2
10	salivary gland disease	9.9	KIT CD40LG
11	isolated growth hormone deficiency type iii	9.9	CD40LG CD2
12	indolent systemic mastocytosis	9.9	KIT CD2
13	testicular disease	9.9	KIT CD40LG
14	systemic mastocytosis	9.9	KIT CD2
15	mastocytosis	9.9	KIT CD2
16	aseptic meningitis	9.9	CD40LG CD2
17	aggressive systemic mastocytosis	9.9	KIT CD2
18	mastocytosis, cutaneous	9.8	KIT CD2
19	small intestinal sarcoma	9.8	PTPRC KIT
20	endometrial small cell carcinoma	9.8	PTPRC KIT
21	small cell carcinoma	9.8	PTPRC KIT
22	glomangiomatosis	9.8	PTPRC KIT
23	mediastinal cancer	9.8	PTPRC KIT
24	conventional fibrosarcoma	9.8	PTPRC KIT
25	retroperitoneum carcinoma	9.8	PTPRC KIT
26	t cell deficiency	9.8	PTPRC CD40LG
27	myeloid sarcoma	9.8	PTPRC KIT
28	monoclonal gammopathy of uncertain significance	9.8	PTPRC CD40LG
29	lymphoplasmacytic lymphoma	9.8	PTPRC CD40LG
30	plasma cell neoplasm	9.8	PTPRC CD40LG
31	thymic carcinoma	9.7	PTPRC KIT
32	lymph node disease	9.7	PTPRC CD40LG
33	reticulum cell sarcoma	9.7	PTPRC CD2
34	angiomyolipoma	9.7	PTPRC KIT
35	blood coagulation disease	9.7	NAAA KIT CD40LG
36	blood platelet disease	9.7	NAAA KIT CD40LG
37	malignant fibrous histiocytoma	9.7	PTPRC KIT
38	merkel cell carcinoma	9.7	PTPRC KIT
39	cutaneous solitary mastocytoma	9.7	KIT CLEC11A CD2
40	mature b-cell neoplasm	9.7	PTPRC CD40LG
41	neuroendocrine carcinoma	9.6	PTPRC KIT
42	autoimmune disease of musculoskeletal system	9.6	PTPRC CD40LG
43	leiomyosarcoma	9.6	PTPRC KIT
44	primary bacterial infectious disease	9.6	PTPRC CD40LG
45	x-linked recessive disease	9.6	PTPRC CD40LG
46	autoimmune hepatitis	9.5	PTPRC CD40LG
47	small cell cancer of the lung	9.5	PTPRC KIT
48	thymus gland disease	9.4	PTPRC KIT CD40LG
49	thymus cancer	9.4	PTPRC KIT CD40LG
50	leukocyte disease	9.4	PTPRC KIT CD40LG

Graphical network of the top 20 diseases related to Benign Mastocytoma:

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Symptoms & Phenotypes for Benign Mastocytoma

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Drugs & Therapeutics for Benign Mastocytoma

Search Clinical Trials , NIH Clinical Center for Benign Mastocytoma

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Genetic Tests for Benign Mastocytoma

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Anatomical Context for Benign Mastocytoma

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Publications for Benign Mastocytoma

Articles related to Benign Mastocytoma:

#	Title	Authors	PMID	Year
1	Diagnostic criteria and classification of mastocytosis: a consensus proposal. ⁶¹	Valent P...Bennett JM	11377686	2001
2	Tissue mast cells in health and disease. ⁶¹	Parwaresch MR...Lennert K	2582403	1985

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Genes for Benign Mastocytoma

Genes related to Benign Mastocytoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CLEC11A	C-Type Lectin Domain Containing 11A	Protein Coding	5.62	DISEASES inferred ¹⁵
2	NAAA	N-Acylethanolamine Acid Amidase	Protein Coding	5.05	DISEASES inferred ¹⁵
3	CD40LG	CD40 Ligand	Protein Coding	4.58	DISEASES inferred ¹⁵
4	CD2	CD2 Molecule	Protein Coding	4.35	DISEASES inferred ¹⁵
5	PTPRC	Protein Tyrosine Phosphatase Receptor Type C	Protein Coding	3.56	DISEASES inferred ¹⁵
6	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	3.55	DISEASES inferred ¹⁵

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Variations for Benign Mastocytoma

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Expression for Benign Mastocytoma

Search GEO for disease gene expression data for Benign Mastocytoma.

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Pathways for Benign Mastocytoma

Pathways related to Benign Mastocytoma according to GeneCards Suite gene sharing:

(show all 12)

#	Super pathways	Score	Top Affiliating Genes
1	Akt Signaling ⁶³ Show member pathways p38 Signaling ⁶³ Tec Kinases Signaling ⁶³	12.88	KIT CLEC11A CD40LG CD2
2	PAK Pathway ⁶³ Show member pathways Antioxidant Action of Vitamin-C ⁶³ Epithelial Adherens Junctions ⁶³	12.42	PTPRC KIT CLEC11A CD40LG CD2
3	Cell adhesion molecules (CAMs) ³⁶	11.67	PTPRC CD40LG CD2
4	Hematopoietic cell lineage ³⁶	11.51	KIT CD2
5	Mesenchymal Stem Cells and Lineage-specific Markers ⁶⁴	11.47	PTPRC KIT
6	NF-kappaB Signaling ⁴	11.44	PTPRC KIT CD40LG CD2
7	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁴	11.4	PTPRC KIT CD2
8	Innate Lymphoid Cells Differentiation ⁶⁴	11.38	PTPRC KIT
9	Dendritic Cells Developmental Lineage Pathway ⁶⁴	11.33	PTPRC KIT
10	Primary immunodeficiency ³⁶	10.98	PTPRC CD40LG
11	A-beta Uptake and Degradation ⁶⁴	10.87	PTPRC CD40LG
12	G-protein signaling_Rap2B regulation pathway ²²	10.46	KIT CLEC11A CD40LG CD2

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GO Terms for Benign Mastocytoma

Cellular components related to Benign Mastocytoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	integral component of plasma membrane	GO:0005887	9.56	PTPRC KIT CD40LG CD2
2	cell surface	GO:0009986	9.46	PTPRC KIT CD40LG CD2
3	external side of plasma membrane	GO:0009897	9.26	PTPRC KIT CD40LG CD2
4	cytoplasmic side of plasma membrane	GO:0009898	8.8	PTPRC KIT CD2

Biological processes related to Benign Mastocytoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	hematopoietic progenitor cell differentiation	GO:0002244	9.46	PTPRC KIT
2	positive regulation of T cell proliferation	GO:0042102	9.43	PTPRC CD40LG
3	positive regulation of tumor necrosis factor production	GO:0032760	9.4	PTPRC CD2
4	T cell activation	GO:0042110	9.37	PTPRC CD2
5	T cell differentiation	GO:0030217	9.32	PTPRC KIT
6	B cell proliferation	GO:0042100	9.26	PTPRC CD40LG
7	leukocyte cell-cell adhesion	GO:0007159	9.16	PTPRC CD40LG
8	heterotypic cell-cell adhesion	GO:0034113	8.96	PTPRC CD2
9	B cell differentiation	GO:0030183	8.8	PTPRC KIT CD40LG

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Sources for Benign Mastocytoma

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