MCID: BNG002
MIFTS: 36

Benign Meningioma

Categories: Cancer diseases, Eye diseases, Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Benign Meningioma

MalaCards integrated aliases for Benign Meningioma:

Name: Benign Meningioma 12 56 15 74
Meningioma, Benign 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4587
MeSH 45 D008579
NCIt 51 C4055
UMLS 74 C0281784

Summaries for Benign Meningioma

MalaCards based summary : Benign Meningioma, also known as meningioma, benign, is related to meningioma, familial and meningioma, radiation-induced. An important gene associated with Benign Meningioma is NF2 (Neurofibromin 2), and among its related pathways/superpathways are Neuroscience and Primary Focal Segmental Glomerulosclerosis FSGS. The drugs Hydroxyurea and Nucleic Acid Synthesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include breast, brain and spinal cord, and related phenotypes are Increased cell death HMECs cells and Increased Nanog expression

Related Diseases for Benign Meningioma

Diseases in the Benign Meningioma family:

Meningioma, Familial

Diseases related to Benign Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
# Related Disease Score Top Affiliating Genes
1 meningioma, familial 31.7 EPB41L3 MKI67 NF2 PGR SMARCE1
2 meningioma, radiation-induced 31.3 EPB41L3 MKI67 NF2 PGR
3 spinal meningioma 30.7 NF2 PGR SMARCE1
4 secretory meningioma 10.4
5 meningothelial meningioma 10.3 NF2 SMARCE1
6 spinal cord ependymoma 10.3 EPB41L3 NF2
7 clear cell meningioma 10.2 PGR SMARCE1
8 olfactory groove meningioma 10.2 NF2 PGR
9 benign ependymoma 10.2 EPB41L3 NF2
10 ependymoma 10.2 MKI67 NF2
11 neurilemmomatosis 10.2 NF2 SMARCE1
12 anterior cranial fossa meningioma 10.2 NF2 PGR
13 intraventricular meningioma 10.2 NF2 TERT
14 benign breast phyllodes tumor 10.2 MKI67 PGR
15 endometrial mucinous adenocarcinoma 10.1 MKI67 PGR
16 breast adenoid cystic carcinoma 10.1 MKI67 PGR
17 neurofibromatosis, type ii 10.1 EPB41L3 NF2
18 adenosarcoma 10.1 MKI67 PGR
19 spermatocele 10.1 PGR TERT
20 spinal canal and spinal cord meningioma 10.0 NF2 PGR SMARCE1
21 soft tissue sarcoma 10.0 MKI67 TERT
22 brain edema 10.0
23 breast fibroadenoma 10.0 MKI67 PGR
24 panophthalmitis 10.0 CTSL TERT
25 ductal carcinoma in situ 10.0 MKI67 PGR
26 hemangiopericytoma, malignant 9.9
27 cervical carcinosarcoma 9.9 BIRC5 PGR
28 purulent endophthalmitis 9.9 CTSL TERT
29 keratocystic odontogenic tumor 9.8 BIRC5 MKI67
30 cerebral amyloid angiopathy, cst3-related 9.8
31 skull base meningioma 9.8
32 ovarian serous cystadenocarcinoma 9.7 BIRC5 PGR
33 cervical intraepithelial neoplasia 9.6 BIRC5 MKI67 TERT
34 gingival overgrowth 9.6 CTSB CTSL
35 adamantinoma of long bones 9.6 BIRC5 PGR TERT

Graphical network of the top 20 diseases related to Benign Meningioma:



Diseases related to Benign Meningioma

Symptoms & Phenotypes for Benign Meningioma

GenomeRNAi Phenotypes related to Benign Meningioma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death HMECs cells GR00103-A-0 9.26 BIRC5 CTSB CTSL PGR
2 Increased Nanog expression GR00371-A-1 9.1 BIRC5 MKI67 SMARCE1
3 Increased Nanog expression GR00371-A-2 9.1 SMARCE1
4 Increased Nanog expression GR00371-A-3 9.1 BIRC5
5 Increased Nanog expression GR00371-A-5 9.1 BIRC5

MGI Mouse Phenotypes related to Benign Meningioma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.73 BIRC5 CTSB EPB41L3 NF2 PGR TERT
2 mortality/aging MP:0010768 9.7 BIRC5 CTSB EPB41L3 NF2 PGR SMARCE1
3 neoplasm MP:0002006 9.35 CTSB EPB41L3 NF2 PGR TERT
4 normal MP:0002873 9.1 BIRC5 CTSB EPB41L3 MKI67 PGR TERT

Drugs & Therapeutics for Benign Meningioma

Drugs for Benign Meningioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydroxyurea Approved Phase 2 127-07-1 3657
2 Nucleic Acid Synthesis Inhibitors Phase 2
3 Antiviral Agents Phase 2
4 Iron-Dextran Complex Phase 2
5 interferons Phase 2
6 Immunologic Factors Phase 2
7 Interferon-alpha Phase 2
8 Interferon alpha-2 Phase 2
9 Anti-Infective Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Proton/Photon Rt - Benign Meningiomas(P92-13) Completed NCT02947984 Phase 3
2 Radiotherapy or Radiosurgery Compared With Observation Alone in Treating Patients With Newly Diagnosed, Benign Meningioma That Has Been Partially Removed by Surgery Terminated NCT00104936 Phase 3
3 S9811 Hydroxyurea in Treating Patients With Unresectable Benign Meningioma Completed NCT00003590 Phase 2 hydroxyurea
4 Interferon Alfa in Treating Patients With Recurrent Unresectable Meningiomas and Malignant Meningiomas Completed NCT00002965 Phase 2
5 Multisession Radiosurgery in Large Meningiomas Active, not recruiting NCT02974127

Search NIH Clinical Center for Benign Meningioma

Genetic Tests for Benign Meningioma

Anatomical Context for Benign Meningioma

MalaCards organs/tissues related to Benign Meningioma:

42
Breast, Brain, Spinal Cord, Lung, Bone, Eye

Publications for Benign Meningioma

Articles related to Benign Meningioma:

(show all 32)
# Title Authors Year
1
Challenging the concept that late recurrence and death from tumor are common after fractionated radiotherapy for benign meningioma. ( 31071515 )
2019
2
Long-Term Outcomes After Gamma Knife Radiosurgery for Benign Meningioma: A Single Institution's Experience With 424 Patients. ( 29538718 )
2018
3
Risk of benign meningioma after childhood cancer in the DCOG-LATER cohort: contributions of radiation dose, exposed cranial volume, and age. ( 30099534 )
2018
4
Stereotactic radiosurgery versus fractionated stereotactic radiotherapy in benign meningioma. ( 27815026 )
2017
5
Invasive benign meningioma: Clinical characteristics, surgical strategies and outcomes from a single neurosurgical institute. ( 27284345 )
2016
6
Review of controversies in management of non-benign meningioma. ( 27338209 )
2016
7
A case of benign meningioma presented with subdural hemorrhage. ( 25977904 )
2015
8
Cerebral amyloid angiopathy-related infarcts imitating high-grade differentiation of a benign meningioma. ( 26385916 )
2015
9
Stereotactic radiation therapy for benign meningioma: long-term outcome in 318 patients. ( 24751409 )
2014
10
Stereotactic radiotherapy of benign meningioma in the elderly: clinical outcome and toxicity in 121 patients. ( 24813096 )
2014
11
Gene expression profiles of metabolic aggressiveness and tumor recurrence in benign meningioma. ( 23840654 )
2013
12
Projected second tumor risk and dose to neurocognitive structures after proton versus photon radiotherapy for benign meningioma. ( 22285662 )
2012
13
Impaired survival and long-term neurological problems in benign meningioma. ( 22406926 )
2012
14
Analysis of gene expression profiling in meningioma: deregulated signaling pathways associated with meningioma and EGFL6 overexpression in benign meningioma tissue and serum. ( 23285163 )
2012
15
Is a benign meningioma always an indolent tumor? ( 21486754 )
2011
16
Quantitative evaluation of benign meningioma and hemangiopericytoma with peritumoral brain edema by 64-slice CT perfusion imaging. ( 20819539 )
2010
17
Benign meningioma developing late lung metastases: case report and review of the literature. ( 19919820 )
2009
18
How a Brain Tumour took over my Life: Diagnosis and removal of a benign meningioma. ( 21509301 )
2009
19
Iatrogenic metastasis of a benign meningioma to the periosteum at the site of previous craniotomy: a case report. ( 19122989 )
2008
20
Gamma Knife surgery for benign meningioma. ( 17695387 )
2007
21
Age associated increase in the prevalence of chromosome 22q loss of heterozygosity in histological subsets of benign meningioma. ( 15980114 )
2006
22
Establishment of a benign meningioma cell line by hTERT-mediated immortalization. ( 15965488 )
2005
23
Functional outcome of patients with benign meningioma treated by 3D conformal irradiation with a combination of photons and protons. ( 16029801 )
2005
24
Early recurrence of benign meningioma correlates with expression of mini-chromosome maintenance-2 protein. ( 11928726 )
2002
25
Benign meningioma metastasizing through CSF pathways: a case report and review of literature. ( 12391463 )
2002
26
An iatrogenic epidemic of benign meningioma. ( 10670551 )
2000
27
Long-term follow up of progesterone receptor status in benign meningioma: a prognostic indicator of recurrence? ( 10701525 )
2000
28
Benign meningioma: partially resected, biopsied, and recurrent intracranial tumors treated with combined proton and photon radiotherapy. ( 11121635 )
2000
29
Radiotherapy in the treatment of benign meningioma of the skull base. ( 10223446 )
1999
30
Images in pathology. Benign meningioma. ( 10458841 )
1999
31
Hemangiopericytoma arising at the site of a dural graft 13 years after total removal of a benign meningioma--case report. ( 9919906 )
1998
32
Benign meningioma with a short latency period following irradiation. ( 1440212 )
1992

Variations for Benign Meningioma

Expression for Benign Meningioma

Search GEO for disease gene expression data for Benign Meningioma.

Pathways for Benign Meningioma

Pathways related to Benign Meningioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.33 CTSB MKI67 NF2
2 10.82 CTSL MKI67

GO Terms for Benign Meningioma

Cellular components related to Benign Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromosome GO:0000228 8.96 BIRC5 SMARCE1
2 endolysosome lumen GO:0036021 8.62 CTSB CTSL

Biological processes related to Benign Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of apoptotic process GO:0042981 9.33 BIRC5 CTSB NF2
2 proteolysis involved in cellular protein catabolic process GO:0051603 9.26 CTSB CTSL
3 collagen catabolic process GO:0030574 8.96 CTSB CTSL
4 cellular response to thyroid hormone stimulus GO:0097067 8.62 CTSB CTSL

Molecular functions related to Benign Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.61 BIRC5 CTSB CTSL EPB41L3 MKI67 NF2
2 collagen binding GO:0005518 9.16 CTSB CTSL
3 proteoglycan binding GO:0043394 8.62 CTSB CTSL

Sources for Benign Meningioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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