MCID: BNG002
MIFTS: 39

Benign Meningioma

Categories: Cancer diseases, Eye diseases, Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Benign Meningioma

MalaCards integrated aliases for Benign Meningioma:

Name: Benign Meningioma 12 54 15 71
Meningioma, Benign 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4587
MeSH 43 D008579
NCIt 49 C4055
SNOMED-CT 67 724171006
UMLS 71 C0281784

Summaries for Benign Meningioma

MalaCards based summary : Benign Meningioma, also known as meningioma, benign, is related to secretory meningioma and spinal meningioma. An important gene associated with Benign Meningioma is NF2 (Neurofibromin 2), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Hydroxyurea and Gefitinib have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and bone, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Benign Meningioma

Diseases in the Benign Meningioma family:

Meningioma, Familial

Diseases related to Benign Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Related Disease Score Top Affiliating Genes
1 secretory meningioma 30.7 TRAF7 SMARCE1 NF2 EGFL6
2 spinal meningioma 30.7 TRAF7 SMARCE1 PGR NF2
3 meningioma, familial 30.7 TRAF7 TERT SMARCE1 PGR PCNA NF2
4 meningioma, radiation-induced 30.6 PGR PCNA NF2 MKI67 EPB41L3
5 brain meningioma 30.5 TRAF7 NF2
6 neurofibromatosis, type ii 30.0 PGR NF2 EPB41L3
7 fibrous meningioma 29.9 TRAF7 NF2 EGFL6
8 meningothelial meningioma 29.8 TRAF7 SMARCE1 PGR NF2
9 intraventricular meningioma 29.7 TRAF7 NF2
10 skull base meningioma 29.5 TRAF7 NF2
11 lymphoplasmacyte-rich meningioma 10.7
12 peripheral nerve schwannoma 10.5 SMARCE1 NF2
13 lung meningioma 10.5 PGR NF2
14 polyp of corpus uteri 10.4 PGR NF2
15 apocrine adenosis of breast 10.4 PGR CCNA2
16 pleomorphic lipoma 10.3 PGR MDM2
17 spinal cord ependymoma 10.3 NF2 EPB41L3
18 anaplastic ependymoma 10.3 NF2 MDM2
19 malignant peritoneal mesothelioma 10.3 NF2 BIRC5
20 soft tissue sarcoma 10.3 MKI67 MDM2
21 benign breast phyllodes tumor 10.3 PGR MKI67
22 embryonal sarcoma 10.3 MKI67 MDM2
23 cerebral aneurysms 10.3 CTSB CST3
24 adult malignant schwannoma 10.2 NF2 BIRC5
25 lymphangiomatosis 10.2 PGR PCNA
26 cerebral meningioma 10.2 PGR NF2
27 myxofibrosarcoma 10.1 MKI67 MDM2 CCNA2
28 bizarre leiomyoma 10.1 PGR PCNA
29 malignant spiradenoma 10.1 PGR MDM2
30 bowen's disease 10.1 PCNA MKI67
31 cervical intraepithelial neoplasia 10.1 TERT MKI67 BIRC5
32 chordoid glioma 10.1 PGR NF2
33 brain edema 10.1
34 oral leukoplakia 10.1 PCNA MKI67
35 keratocystic odontogenic tumor 10.0 MKI67 BIRC5
36 pediatric meningioma 10.0 TRAF7 NF2
37 olfactory groove meningioma 10.0 TRAF7 NF2
38 psammomatous meningioma 10.0 TRAF7 NF2
39 anterior cranial fossa meningioma 10.0 TRAF7 NF2
40 neurofibromatosis 10.0
41 intraneural perineurioma 10.0 TRAF7 NF2
42 inflammatory myofibroblastic tumor 10.0 MKI67 MDM2 BIRC5
43 gastrointestinal stromal tumor 10.0 NF2 MKI67 CTSL CCNA2
44 ductal carcinoma in situ 10.0 PLAU PGR MKI67
45 bladder adenocarcinoma 10.0 PCNA MKI67
46 aortic aneurysm, familial abdominal, 1 9.9 PLAU CTSL CST3
47 chordoid meningioma 9.9 TRAF7 NF2
48 rhabdoid meningioma 9.9 TRAF7 NF2
49 angiomatous meningioma 9.9 TRAF7 SMARCE1 NF2
50 hemangiopericytoma, malignant 9.9

Graphical network of the top 20 diseases related to Benign Meningioma:



Diseases related to Benign Meningioma

Symptoms & Phenotypes for Benign Meningioma

GenomeRNAi Phenotypes related to Benign Meningioma according to GeneCards Suite gene sharing:

26 (show all 38)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 10.39 CTSB
2 Decreased viability GR00055-A-2 10.39 CTSB
3 Decreased viability GR00055-A-3 10.39 NF2
4 Decreased viability GR00221-A-3 10.39 NF2
5 Decreased viability GR00240-S-1 10.39 CTSL PLAU
6 Decreased viability GR00249-S 10.39 BIRC5 CCNA2 CTSB MKI67 NF2 TERT
7 Decreased viability GR00381-A-1 10.39 BIRC5 CCNA2 MDM2
8 Decreased viability GR00386-A-1 10.39 BIRC5 CCNA2 EGFL6 MKI67 PCNA PGR
9 Decreased viability GR00402-S-2 10.39 BIRC5 CCNA2 CST3 EGFL6 MIA2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.78 CTSB
11 Increased shRNA abundance (Z-score > 2) GR00366-A-109 9.78 SMARCE1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-111 9.78 EGFL6
13 Increased shRNA abundance (Z-score > 2) GR00366-A-116 9.78 CTSB EGFL6
14 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.78 CTSB MDM2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-119 9.78 CTSB
16 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.78 EGFL6
17 Increased shRNA abundance (Z-score > 2) GR00366-A-13 9.78 CTSB
18 Increased shRNA abundance (Z-score > 2) GR00366-A-136 9.78 MDM2
19 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.78 EGFL6
20 Increased shRNA abundance (Z-score > 2) GR00366-A-14 9.78 CTSB
21 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.78 MDM2
22 Increased shRNA abundance (Z-score > 2) GR00366-A-153 9.78 MDM2
23 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.78 CTSB
24 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.78 SMARCE1
25 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.78 SMARCE1
26 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.78 CTSB
27 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.78 EGFL6
28 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.78 CTSB EGFL6 MDM2 SMARCE1
29 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.78 EGFL6
30 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.78 SMARCE1
31 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.78 MDM2
32 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.78 MDM2
33 Increased shRNA abundance (Z-score > 2) GR00366-A-84 9.78 SMARCE1
34 Increased Nanog expression GR00371-A-1 9.56 BIRC5 MCM7 MKI67 PCNA SMARCE1
35 Increased Nanog expression GR00371-A-2 9.56 SMARCE1
36 Increased Nanog expression GR00371-A-3 9.56 BIRC5
37 Increased Nanog expression GR00371-A-5 9.56 BIRC5
38 Increased cell death in HCT116 cells GR00103-A-0 9.16 MDM2 PCNA

MGI Mouse Phenotypes related to Benign Meningioma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.18 BIRC5 CCNA2 CST3 CTSB EPB41L3 ETS1
2 endocrine/exocrine gland MP:0005379 10.11 BIRC5 CST3 CTSB EPB41L3 ETS1 MDM2
3 immune system MP:0005387 10.1 BIRC5 CCNA2 CTSB ETS1 MDM2 NF2
4 mortality/aging MP:0010768 10.1 BIRC5 CCNA2 CST3 CTSB EPB41L3 ETS1
5 neoplasm MP:0002006 9.76 CST3 CTSB EPB41L3 MDM2 NF2 PGR
6 normal MP:0002873 9.56 BIRC5 CTSB EGFL6 EPB41L3 MDM2 MKI67
7 reproductive system MP:0005389 9.28 CST3 EPB41L3 MDM2 NF2 PCNA PGR

Drugs & Therapeutics for Benign Meningioma

Drugs for Benign Meningioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydroxyurea Approved Phase 2 127-07-1 3657
2
Gefitinib Approved, Investigational Phase 2 184475-35-2 123631
3 Protein Kinase Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prospective Study Of Patients With Recurrent Or Incomplete Excised Benign Intercranial Meningiomas For The Evaluation Of Treatment Result With Combined Proton And Photon Irradiation To Doses 55.8 Or 63.0 CGE Completed NCT02947984 Phase 3
2 Observation Versus Conventional-Fractionated Radiotherapy or Radiosurgery After Non-radical Surgery for Benign Intracranial Meningiomas: A Phase III Study Terminated NCT00104936 Phase 3
3 Phase II Study of Hydroxyurea for Unresectable Meningioma Completed NCT00003590 Phase 2 hydroxyurea
4 ZD1839 FOR Treatment Of Recurrent Or Progressive Malignant Astrocytoma Or Glioblastoma And Recurrent Or Progressive Meningioma: A Phase II Study With A Phase I Component For Patients Receiving EIAEDs Completed NCT00025675 Phase 2 gefitinib
5 Multisession Radiosurgery in Large Meningiomas Active, not recruiting NCT02974127

Search NIH Clinical Center for Benign Meningioma

Genetic Tests for Benign Meningioma

Anatomical Context for Benign Meningioma

MalaCards organs/tissues related to Benign Meningioma:

40
Brain, Lung, Bone, Liver, Breast, Prostate, Pineal

Publications for Benign Meningioma

Articles related to Benign Meningioma:

(show top 50) (show all 257)
# Title Authors PMID Year
1
Modeling NF2 with human arachnoidal and meningioma cell culture systems: NF2 silencing reflects the benign character of tumor growth. 61 54
17962031 2008
2
Establishment of an in vivo meningioma model with human telomerase reverse transcriptase. 54 61
17415213 2007
3
Protein 4.1B/differentially expressed in adenocarcinoma of the lung-1 functions as a growth suppressor in meningioma cells by activating Rac1-dependent c-Jun-NH(2)-kinase signaling. 54 61
16707455 2006
4
Age associated increase in the prevalence of chromosome 22q loss of heterozygosity in histological subsets of benign meningioma. 61 54
15980114 2006
5
Cathepsins B and L are markers for clinically invasive types of meningiomas. 54 61
11270551 2001
6
Long-term follow up of progesterone receptor status in benign meningioma: a prognostic indicator of recurrence? 61 54
10701525 2000
7
Production of urokinase-type plasminogen activator (u-PA) and plasminogen activator inhibitor-1 (PAI-1) in human brain tumours. 54 61
9689330 1998
8
17 beta-Hydroxysteroid dehydrogenase activity correlates with the type-2 17 beta-hydroxysteroid dehydrogenase mRNA abundance in human meningioma tumors. 61 54
8811669 1996
9
Characterization of 17 beta-hydroxysteroid dehydrogenase activity and mRNA abundance in human meningioma tumors. 54 61
7824086 1994
10
Low recurrence after Simpson grade II resection of spinal benign meningiomas in a single-institute 10-year retrospective study. 61
32360158 2020
11
Commentary: Stereotactic Radiosurgery for Intracranial Noncavernous Sinus Benign Meningioma: International Stereotactic Radiosurgery Society Systematic Review, Meta-Analysis and Practice Guideline. 61
32570276 2020
12
Intravenous sinus meningioma with intraluminal extension to the internal jugular vein: case report and review of the literature. 61
32536219 2020
13
Stereotactic Radiosurgery for Intracranial Noncavernous Sinus Benign Meningioma: International Stereotactic Radiosurgery Society Systematic Review, Meta-Analysis and Practice Guideline. 61
32463867 2020
14
Outcomes of benign meningioma in older patients in the United States. 61
31718937 2020
15
Benign Meningioma With Rare Osteolytic Behavior. 61
31574040 2020
16
Predictive factors for high-grade transformation in benign meningiomas. 61
32505062 2020
17
Infiltration of Benign Meningioma into Sagittal Sinus and Subsequent Metastasis to Lung: Case Report and Literature Review. 61
31899401 2020
18
MicroRNA-195 Functions as a Tumor Suppressor by Directly Targeting Fatty Acid Synthase in Malignant Meningioma. 61
31927122 2020
19
Iatrogenic Acute Ischemic Necrosis Due to Emergent Bleeding Control in Ventral Foramen Magnum Meningioma with Spinal Instability. 61
32455071 2020
20
Forkhead box M1 (FOXM1) transcription factor is a key oncogenic driver of aggressive human meningioma progression. 61
31179553 2020
21
Factors affecting serum lactate in patients with intracranial tumors - A report of our series and review of the literature. 61
32257565 2020
22
Factors Related to the Post-operative Recurrence of Atypical Meningiomas. 61
32351890 2020
23
The Prognostic Value of Pretreatment Gallium-68 DOTATATE Positron Emission Tomography/Computed Tomography in Irradiated Non-benign Meningioma. 61
31579356 2019
24
Geriatric brain tumor management part I: Meningioma. 61
31208835 2019
25
Challenging the concept that late recurrence and death from tumor are common after fractionated radiotherapy for benign meningioma. 61
31071515 2019
26
Risk of benign meningioma after childhood cancer in the DCOG-LATER cohort: contributions of radiation dose, exposed cranial volume, and age. 61
30099534 2019
27
Latency-shift of intra-operative visual evoked potential predicts reversible homonymous hemianopia after intra-ventricular meningioma surgery. 61
31886448 2019
28
A Patient with a Benign and a Malignant Primary Pulmonary Meningioma: An Evaluation with 18F Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography and Computed Tomography with Iodinated Contrast. 61
30713380 2019
29
Giant intercostal nerve schwannoma in a patient with neurofibromatosis type 2. 61
29983103 2018
30
Long-Term Outcomes After Gamma Knife Radiosurgery for Benign Meningioma: A Single Institution's Experience With 424 Patients. 61
29538718 2018
31
Long-term stroke risk of single-fraction photon-based stereotactic radiosurgery for meningioma. 61
30145526 2018
32
Collision Tumor of Glioblastoma and Meningioma: Case Report and Literature Review. 61
29890277 2018
33
Adjuvant postoperative high-dose radiotherapy for atypical and malignant meningioma: A phase-II parallel non-randomized and observation study (EORTC 22042-26042). 61
29960684 2018
34
Ethics and meningiomas: From prudence to obstinacy? The position of the neurosurgeon (for treatment or insurance purposes) in the case of complaints concerning post-operative clinical deterioration. 61
25599871 2018
35
Kinome and phosphoproteome of high-grade meningiomas reveal AKAP12 as a central regulator of aggressiveness and its possible role in progression. 61
29391485 2018
36
Differentiating meningioma grade by imaging features on magnetic resonance imaging. 61
29174756 2018
37
Incidental Metastatic Meningioma Presenting as a Large Liver Mass. 61
29854500 2018
38
Overexpression of eIF4F components in meningiomas and suppression of meningioma cell growth by inhibiting translation initiation. 61
28610844 2018
39
Tumor-to-tumor metastasis: lung adenocarcinoma metastasizing to intracranial benign meningioma as a first clinical manifestation, with literature review. 61
31938406 2018
40
Multimodal treatment of parasagittal meningiomas: a single-center experience. 61
28156245 2017
41
Progression-Free Survival and Factors Associated with Postoperative Recurrence in 126 Patients with Atypical Intracranial Meningioma. 61
28838877 2017
42
Epilepsy and adverse quality of life in surgically resected meningioma. 61
27861722 2017
43
Nuclear spatial and spectral features based evolutionary method for meningioma subtypes classification in histopathology. 61
28379628 2017
44
Tissue thioredoxin-interacting protein expression predicted recurrence in patients with meningiomas. 61
28243945 2017
45
Animal models of meningiomas. 61
28595424 2017
46
Meningioma with the unique coexistence of secretory and lipomatous components: A case report with immunohistochemical study. 61
28937376 2017
47
Radiation therapy for WHO grade I meningioma. 61
28758408 2017
48
Recurrent intraventricular meningioma with malignant transformation. 61
28761542 2017
49
Osteolytic Skull Lesions-Our Experience. 61
28694627 2017
50
Hemangiopericytoma Arose From the Site of Meningioma Resection. 61
28230593 2017

Variations for Benign Meningioma

Expression for Benign Meningioma

Search GEO for disease gene expression data for Benign Meningioma.

Pathways for Benign Meningioma

GO Terms for Benign Meningioma

Cellular components related to Benign Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleolus GO:0005730 9.5 TRAF7 TERT NF2 MKI67 MDM2 MCM7
2 basement membrane GO:0005604 9.33 PTN EGFL6 CST3
3 endolysosome lumen GO:0036021 8.62 CTSL CTSB

Biological processes related to Benign Meningioma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.88 PTN MDM2 ETS1 CST3 BIRC5
2 response to drug GO:0042493 9.8 PTN MDM2 MCM7 CST3
3 cellular response to organic cyclic compound GO:0071407 9.58 PTN MDM2 CCNA2
4 cellular response to hypoxia GO:0071456 9.56 TERT PTN MDM2 CCNA2
5 proteolysis involved in cellular protein catabolic process GO:0051603 9.54 MDM2 CTSL CTSB
6 cellular response to thyroid hormone stimulus GO:0097067 9.46 CTSL CTSB
7 negative regulation of glial cell proliferation GO:0060253 9.43 TERT PTN
8 estrous cycle GO:0044849 9.33 PTN PCNA ETS1
9 cellular response to xenobiotic stimulus GO:0071466 9.32 PCNA MCM7
10 cellular response to hydrogen peroxide GO:0070301 9.26 PCNA MDM2 ETS1 CST3
11 response to estradiol GO:0032355 9.02 PTN PCNA ETS1 CST3 CCNA2

Molecular functions related to Benign Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.93 TRAF7 TERT SMARCE1 PTN PLAU PGR
2 identical protein binding GO:0042802 9.7 TERT PGR PCNA MDM2 ETS1 CST3
3 protein N-terminus binding GO:0047485 9.43 TERT SMARCE1 MDM2
4 proteoglycan binding GO:0043394 8.8 PTN CTSL CTSB

Sources for Benign Meningioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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