MCID: BNG002
MIFTS: 38

Benign Meningioma

Categories: Cancer diseases, Eye diseases, Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Benign Meningioma

MalaCards integrated aliases for Benign Meningioma:

Name: Benign Meningioma 12 55 15 72
Meningioma, Benign 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4587
MeSH 44 D008579
NCIt 50 C4055
UMLS 72 C0281784

Summaries for Benign Meningioma

MalaCards based summary : Benign Meningioma, also known as meningioma, benign, is related to meningioma, familial and spinal meningioma. An important gene associated with Benign Meningioma is NF2 (Neurofibromin 2), and among its related pathways/superpathways are Pathways in cancer and Apoptosis Modulation and Signaling. The drugs Hydroxyurea and Nucleic Acid Synthesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and bone, and related phenotypes are Increased cell death HMECs cells and cellular

Related Diseases for Benign Meningioma

Diseases in the Benign Meningioma family:

Meningioma, Familial

Diseases related to Benign Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 meningioma, familial 32.2 SMARCE1 PGR NF2 MKI67 EPB41L3
2 spinal meningioma 31.5 SMARCE1 PGR NF2
3 meningothelial meningioma 31.0 SMARCE1 NF2
4 meningioma, radiation-induced 31.0 PGR NF2 MKI67 EPB41L3
5 intraventricular meningioma 30.4 TERT NF2
6 secretory meningioma 10.7
7 lymphoplasmacyte-rich meningioma 10.7
8 spinal cord ependymoma 10.6 NF2 EPB41L3
9 olfactory groove meningioma 10.5 PGR NF2
10 clear cell meningioma 10.5 SMARCE1 PGR
11 benign ependymoma 10.5 NF2 EPB41L3
12 anterior cranial fossa meningioma 10.5 PGR NF2
13 benign breast phyllodes tumor 10.5 PGR MKI67
14 endometrial mucinous adenocarcinoma 10.5 PGR MKI67
15 breast adenoid cystic carcinoma 10.4 PGR MKI67
16 panophthalmitis 10.4 TERT CTSL
17 spermatocele 10.4 TERT PGR
18 adenosarcoma 10.4 PGR MKI67
19 neurilemmomatosis 10.3 SMARCE1 NF2
20 spinal canal and spinal cord meningioma 10.3 SMARCE1 PGR NF2
21 pleomorphic lipoma 10.3 PGR MDM2
22 anaplastic ependymoma 10.3 NF2 MDM2
23 cervical carcinosarcoma 10.3 PGR BIRC5
24 spindle cell sarcoma 10.2 NF2 MDM2
25 small cell sarcoma 10.2 NF2 MDM2
26 brain meningioma 10.2
27 embryonal sarcoma 10.1 MKI67 MDM2
28 neurofibromatosis, type iv, of riccardi 10.0
29 hydrops, lactic acidosis, and sideroblastic anemia 10.0
30 brain edema 10.0
31 fibrous meningioma 10.0
32 soft tissue sarcoma 10.0 TERT MKI67 MDM2
33 purulent endophthalmitis 10.0 TERT CTSL
34 cervical intraepithelial neoplasia 10.0 TERT MKI67 BIRC5
35 hemangiopericytoma, malignant 9.9
36 tinea capitis 9.9
37 pulmonary coin lesion 9.9
38 dermatophytosis 9.9
39 rare surgical neurologic disease 9.9
40 keratocystic odontogenic tumor 9.9 MKI67 BIRC5
41 myxofibrosarcoma 9.9 MKI67 MDM2 CCNA2
42 neurofibromatosis, type ii 9.8
43 cerebral amyloid angiopathy, cst3-related 9.8
44 pituitary hormone deficiency, combined, 2 9.8
45 ataxia and polyneuropathy, adult-onset 9.8
46 hydrocephalus 9.8
47 optic nerve disease 9.8
48 skull base meningioma 9.8
49 optic nerve sheath meningioma 9.8
50 pineal region meningioma 9.8

Graphical network of the top 20 diseases related to Benign Meningioma:



Diseases related to Benign Meningioma

Symptoms & Phenotypes for Benign Meningioma

GenomeRNAi Phenotypes related to Benign Meningioma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death HMECs cells GR00103-A-0 9.1 BIRC5 CCNA2 CTSB CTSL MDM2 PGR

MGI Mouse Phenotypes related to Benign Meningioma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.01 BIRC5 CCNA2 CTSB EPB41L3 ETS1 MDM2
2 endocrine/exocrine gland MP:0005379 9.92 BIRC5 CTSB EPB41L3 ETS1 MDM2 NF2
3 immune system MP:0005387 9.91 BIRC5 CCNA2 CTSB ETS1 MDM2 NF2
4 mortality/aging MP:0010768 9.9 BIRC5 CCNA2 CST3 CTSB EPB41L3 ETS1
5 embryo MP:0005380 9.85 BIRC5 CCNA2 ETS1 MDM2 NF2 PGR
6 neoplasm MP:0002006 9.5 CST3 CTSB EPB41L3 MDM2 NF2 PGR
7 normal MP:0002873 9.17 BIRC5 CTSB EPB41L3 MDM2 MKI67 PGR

Drugs & Therapeutics for Benign Meningioma

Drugs for Benign Meningioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydroxyurea Approved Phase 2 127-07-1 3657
2 Nucleic Acid Synthesis Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prospective Study Of Patients With Recurrent Or Incomplete Excised Benign Intercranial Meningiomas For The Evaluation Of Treatment Result With Combined Proton And Photon Irradiation To Doses 55.8 Or 63.0 CGE Completed NCT02947984 Phase 3
2 Observation Versus Conventional-Fractionated Radiotherapy or Radiosurgery After Non-radical Surgery for Benign Intracranial Meningiomas: A Phase III Study Terminated NCT00104936 Phase 3
3 Phase II Study of Hydroxyurea for Unresectable Meningioma Completed NCT00003590 Phase 2 hydroxyurea
4 Multisession Radiosurgery in Large Meningiomas Active, not recruiting NCT02974127

Search NIH Clinical Center for Benign Meningioma

Genetic Tests for Benign Meningioma

Anatomical Context for Benign Meningioma

MalaCards organs/tissues related to Benign Meningioma:

41
Brain, Lung, Bone, Liver, Prostate, Breast, Pineal

Publications for Benign Meningioma

Articles related to Benign Meningioma:

(show top 50) (show all 242)
# Title Authors PMID Year
1
Modeling NF2 with human arachnoidal and meningioma cell culture systems: NF2 silencing reflects the benign character of tumor growth. 9 38
17962031 2008
2
Establishment of an in vivo meningioma model with human telomerase reverse transcriptase. 9 38
17415213 2007
3
Protein 4.1B/differentially expressed in adenocarcinoma of the lung-1 functions as a growth suppressor in meningioma cells by activating Rac1-dependent c-Jun-NH(2)-kinase signaling. 9 38
16707455 2006
4
Age associated increase in the prevalence of chromosome 22q loss of heterozygosity in histological subsets of benign meningioma. 9 38
15980114 2006
5
Cathepsins B and L are markers for clinically invasive types of meningiomas. 9 38
11270551 2001
6
Long-term follow up of progesterone receptor status in benign meningioma: a prognostic indicator of recurrence? 9 38
10701525 2000
7
Production of urokinase-type plasminogen activator (u-PA) and plasminogen activator inhibitor-1 (PAI-1) in human brain tumours. 9 38
9689330 1998
8
17 beta-Hydroxysteroid dehydrogenase activity correlates with the type-2 17 beta-hydroxysteroid dehydrogenase mRNA abundance in human meningioma tumors. 9 38
8811669 1996
9
Characterization of 17 beta-hydroxysteroid dehydrogenase activity and mRNA abundance in human meningioma tumors. 9 38
7824086 1994
10
Geriatric brain tumor management part I: Meningioma. 38
31208835 2019
11
Challenging the concept that late recurrence and death from tumor are common after fractionated radiotherapy for benign meningioma. 38
31071515 2019
12
Forkhead box M1 (FOXM1) transcription factor is a key oncogenic driver of aggressive human meningioma progression. 38
31179553 2019
13
Risk of benign meningioma after childhood cancer in the DCOG-LATER cohort: contributions of radiation dose, exposed cranial volume, and age. 38
30099534 2019
14
A Patient with a Benign and a Malignant Primary Pulmonary Meningioma: An Evaluation with 18F Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography and Computed Tomography with Iodinated Contrast. 38
30713380 2019
15
Giant intercostal nerve schwannoma in a patient with neurofibromatosis type 2. 38
29983103 2018
16
Long-Term Outcomes After Gamma Knife Radiosurgery for Benign Meningioma: A Single Institution's Experience With 424 Patients. 38
29538718 2018
17
Long-term stroke risk of single-fraction photon-based stereotactic radiosurgery for meningioma. 38
30145526 2018
18
Collision Tumor of Glioblastoma and Meningioma: Case Report and Literature Review. 38
29890277 2018
19
Adjuvant postoperative high-dose radiotherapy for atypical and malignant meningioma: A phase-II parallel non-randomized and observation study (EORTC 22042-26042). 38
29960684 2018
20
Ethics and meningiomas: From prudence to obstinacy? The position of the neurosurgeon (for treatment or insurance purposes) in the case of complaints concerning post-operative clinical deterioration. 38
25599871 2018
21
Kinome and phosphoproteome of high-grade meningiomas reveal AKAP12 as a central regulator of aggressiveness and its possible role in progression. 38
29391485 2018
22
Differentiating meningioma grade by imaging features on magnetic resonance imaging. 38
29174756 2018
23
Incidental Metastatic Meningioma Presenting as a Large Liver Mass. 38
29854500 2018
24
Overexpression of eIF4F components in meningiomas and suppression of meningioma cell growth by inhibiting translation initiation. 38
28610844 2018
25
Multimodal treatment of parasagittal meningiomas: a single-center experience. 38
28156245 2017
26
Progression-Free Survival and Factors Associated with Postoperative Recurrence in 126 Patients with Atypical Intracranial Meningioma. 38
28838877 2017
27
Epilepsy and adverse quality of life in surgically resected meningioma. 38
27861722 2017
28
Nuclear spatial and spectral features based evolutionary method for meningioma subtypes classification in histopathology. 38
28379628 2017
29
Tissue thioredoxin-interacting protein expression predicted recurrence in patients with meningiomas. 38
28243945 2017
30
Meningioma with the unique coexistence of secretory and lipomatous components: A case report with immunohistochemical study. 38
28937376 2017
31
Radiation therapy for WHO grade I meningioma. 38
28758408 2017
32
Animal models of meningiomas. 38
28595424 2017
33
Osteolytic Skull Lesions-Our Experience. 38
28694627 2017
34
Recurrent intraventricular meningioma with malignant transformation. 38
28761542 2017
35
Hemangiopericytoma Arose From the Site of Meningioma Resection. 38
28230593 2017
36
Pulmonary metastases from benign calvarial meningioma: a case report. 38
27782754 2017
37
Stereotactic radiosurgery versus fractionated stereotactic radiotherapy in benign meningioma. 38
27815026 2017
38
Fractal Analysis May Improve the Preoperative Identification of Atypical Meningiomas. 38
28173535 2017
39
Analysis of the results of recurrent intracranial meningiomas treated with re-radiosurgery. 38
28081463 2017
40
The role and regulatory mechanism of IL-1β on the methylation of the NF2 gene in benign meningiomas and leptomeninges. 38
26840621 2016
41
Sclerosing Meningioma : Radiological and Clinical Characteristics of 21 Cases. 38
27847571 2016
42
[Traumatic bilateral posterior shoulder dislocation after a seizure]. 38
27908322 2016
43
Clinical and Radiological Characteristics of Angiomatous Meningiomas. 38
27867918 2016
44
Review of controversies in management of non-benign meningioma. 38
27338209 2016
45
Acute Progression of Recurrent Meningioma during Luteinizing Hormone-Releasing Hormone Agonist Treatment for Prostate Cancer. 38
27046016 2016
46
The role of diffusion tensor imaging and dynamic susceptibility perfusion MRI in the evaluation of meningioma grade and subtype. 38
27208870 2016
47
Invasive benign meningioma: Clinical characteristics, surgical strategies and outcomes from a single neurosurgical institute. 38
27284345 2016
48
Correlations of magnetic resonance, perfusion-weighed imaging parameters and microvessel density in meningioma. 38
27569094 2016
49
Iatrogenic Seeding of Tumor Cells in Thigh Soft Tissue Upon Surgical Removal of Intracranial Meningioma. 38
27303610 2016
50
The neglected need for psychological intervention in patients suffering from incidentally discovered intracranial aneurysms. 38
26896784 2016

Variations for Benign Meningioma

Expression for Benign Meningioma

Search GEO for disease gene expression data for Benign Meningioma.

Pathways for Benign Meningioma

GO Terms for Benign Meningioma

Cellular components related to Benign Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.65 TERT SMARCE1 PGR NF2 MKI67 MDM2
2 endolysosome lumen GO:0036021 8.62 CTSL CTSB

Biological processes related to Benign Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.5 MDM2 ETS1 BIRC5
2 collagen catabolic process GO:0030574 9.37 CTSL CTSB
3 cellular response to hypoxia GO:0071456 9.33 TERT MDM2 CCNA2
4 positive regulation of vascular associated smooth muscle cell migration GO:1904754 9.26 TERT MDM2
5 cellular response to thyroid hormone stimulus GO:0097067 8.96 CTSL CTSB
6 proteolysis involved in cellular protein catabolic process GO:0051603 8.8 MDM2 CTSL CTSB

Molecular functions related to Benign Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.44 TERT SMARCE1 PGR NF2 MKI67 MDM2
2 protein N-terminus binding GO:0047485 9.43 TERT SMARCE1 MDM2
3 identical protein binding GO:0042802 9.43 TERT PGR MDM2 ETS1 CST3 BIRC5
4 cysteine-type endopeptidase inhibitor activity GO:0004869 9.32 CST3 BIRC5
5 proteoglycan binding GO:0043394 9.16 CTSL CTSB

Sources for Benign Meningioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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