MCID: BNG002
MIFTS: 38

Benign Meningioma

Categories: Cancer diseases, Eye diseases, Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Benign Meningioma

MalaCards integrated aliases for Benign Meningioma:

Name: Benign Meningioma 12 54 15 71
Meningioma, Benign 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4587
MeSH 43 D008579
NCIt 49 C4055
UMLS 71 C0281784

Summaries for Benign Meningioma

MalaCards based summary : Benign Meningioma, also known as meningioma, benign, is related to secretory meningioma and spinal meningioma. An important gene associated with Benign Meningioma is NF2 (Neurofibromin 2), and among its related pathways/superpathways are Mitotic G1-G1/S phases and Cell cycle. The drugs Hydroxyurea and Gefitinib have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and breast, and related phenotypes are Increased cell death HMECs cells and Increased shRNA abundance (Z-score > 2)

Related Diseases for Benign Meningioma

Diseases in the Benign Meningioma family:

Meningioma, Familial

Diseases related to Benign Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Related Disease Score Top Affiliating Genes
1 secretory meningioma 31.1 TRAF7 NF2 EGFL6
2 spinal meningioma 30.8 TRAF7 SMARCE1 PGR NF2
3 brain meningioma 30.6 TRAF7 NF2
4 meningioma, radiation-induced 30.3 PGR PCNA NF2 MKI67 EPB41L3
5 meningioma, familial 30.2 TRAF7 TERT SMARCE1 PGR PCNA NF2
6 fibrous meningioma 30.0 TRAF7 NF2
7 meningothelial meningioma 29.9 TRAF7 SMARCE1 PGR NF2
8 intraventricular meningioma 29.9 TRAF7 NF2
9 skull base meningioma 29.7 TRAF7 PGR NF2
10 lymphoplasmacyte-rich meningioma 10.7
11 peripheral nerve schwannoma 10.5 SMARCE1 NF2
12 lung meningioma 10.5 PGR NF2
13 polyp of corpus uteri 10.4 PGR NF2
14 rete ovarii adenoma 10.4 PGR NF2
15 rete ovarii neoplasm 10.4 PGR NF2
16 apocrine adenosis of breast 10.4 PGR CCNA2
17 pleomorphic lipoma 10.3 PGR MDM2
18 anaplastic ependymoma 10.3 NF2 MDM2
19 spinal cord ependymoma 10.3 NF2 EPB41L3
20 soft tissue sarcoma 10.3 MKI67 MDM2
21 benign breast phyllodes tumor 10.3 PGR MKI67
22 spinal cord glioma 10.2 NF2 EPB41L3
23 embryonal sarcoma 10.2 MKI67 MDM2
24 cerebral aneurysms 10.2 CTSB CST3
25 angiomatous meningioma 10.2 TRAF7 SMARCE1
26 pediatric meningioma 10.2 TRAF7 NF2
27 spinal cancer 10.2 SMARCE1 PGR NF2 EPB41L3
28 psammomatous meningioma 10.2 TRAF7 NF2
29 anterior cranial fossa meningioma 10.2 TRAF7 NF2
30 intraneural perineurioma 10.1 TRAF7 NF2
31 rhabdoid meningioma 10.1 TRAF7 NF2
32 brain edema 10.1
33 olfactory groove meningioma 10.1 TRAF7 SMARCE1 NF2
34 skull base cancer 10.0 TRAF7 PGR NF2
35 lymphangiomatosis 10.0 PGR PCNA
36 neurofibromatosis, type iv, of riccardi 10.0
37 hydrops, lactic acidosis, and sideroblastic anemia 10.0
38 frontal convexity meningioma 10.0 TRAF7 TERT NF2
39 melanotic neuroectodermal tumor 10.0 MDM2 CCNA2
40 bizarre leiomyoma 10.0 PGR PCNA
41 gastrointestinal stromal tumor 9.9 NF2 MKI67 CTSL CCNA2
42 bowen's disease 9.9 PCNA MKI67
43 aortic aneurysm, familial abdominal, 1 9.9 PLAU CTSL CST3
44 ovarian endometrial cancer 9.9 PGR CTSB
45 hemangiopericytoma, malignant 9.9
46 tinea capitis 9.9
47 pulmonary coin lesion 9.9
48 dermatophytosis 9.9
49 rare surgical neurologic disease 9.9
50 spinal canal and spinal cord meningioma 9.9 TRAF7 SMARCE1 PGR NF2

Graphical network of the top 20 diseases related to Benign Meningioma:



Diseases related to Benign Meningioma

Symptoms & Phenotypes for Benign Meningioma

GenomeRNAi Phenotypes related to Benign Meningioma according to GeneCards Suite gene sharing:

26 (show all 23)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death HMECs cells GR00103-A-0 9.76 CCNA2 CTSB CTSL MCM7 MDM2 PCNA
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.72 CTSB
3 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.72 CTSB MDM2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.72 SMARCE1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.72 EGFL6
6 Increased shRNA abundance (Z-score > 2) GR00366-A-13 9.72 CTSB
7 Increased shRNA abundance (Z-score > 2) GR00366-A-136 9.72 MDM2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.72 EGFL6
9 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.72 MDM2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.72 MDM2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.72 CTSB
12 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.72 MDM2 SMARCE1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.72 SMARCE1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.72 CTSB
15 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.72 EGFL6
16 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.72 CTSB EGFL6 MDM2 SMARCE1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.72 EGFL6
18 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.72 SMARCE1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.72 MDM2
20 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.72 MDM2
21 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.72 SMARCE1
22 Increased Nanog expression GR00371-A-1 9.35 MCM7 MKI67 PCNA SMARCE1
23 Increased Nanog expression GR00371-A-2 9.35 SMARCE1

MGI Mouse Phenotypes related to Benign Meningioma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.07 CST3 CTSB EPB41L3 ETS1 MDM2 NF2
2 mortality/aging MP:0010768 10.07 CCNA2 CST3 CTSB EPB41L3 ETS1 MCM7
3 immune system MP:0005387 10.06 CCNA2 CTSB ETS1 MDM2 NF2 PCNA
4 neoplasm MP:0002006 9.76 CST3 CTSB EPB41L3 MDM2 NF2 PGR
5 normal MP:0002873 9.56 CTSB EGFL6 EPB41L3 HSD17B13 MDM2 MKI67
6 reproductive system MP:0005389 9.28 CST3 EPB41L3 MDM2 NF2 PCNA PGR

Drugs & Therapeutics for Benign Meningioma

Drugs for Benign Meningioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydroxyurea Approved Phase 2 127-07-1 3657
2
Gefitinib Approved, Investigational Phase 2 184475-35-2 123631
3 Protein Kinase Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prospective Study Of Patients With Recurrent Or Incomplete Excised Benign Intercranial Meningiomas For The Evaluation Of Treatment Result With Combined Proton And Photon Irradiation To Doses 55.8 Or 63.0 CGE Completed NCT02947984 Phase 3
2 Observation Versus Conventional-Fractionated Radiotherapy or Radiosurgery After Non-radical Surgery for Benign Intracranial Meningiomas: A Phase III Study Terminated NCT00104936 Phase 3
3 Phase II Study of Hydroxyurea for Unresectable Meningioma Completed NCT00003590 Phase 2 hydroxyurea
4 ZD1839 FOR Treatment Of Recurrent Or Progressive Malignant Astrocytoma Or Glioblastoma And Recurrent Or Progressive Meningioma: A Phase II Study With A Phase I Component For Patients Receiving EIAEDs Completed NCT00025675 Phase 2 gefitinib
5 Multisession Radiosurgery in Large Meningiomas Active, not recruiting NCT02974127

Search NIH Clinical Center for Benign Meningioma

Genetic Tests for Benign Meningioma

Anatomical Context for Benign Meningioma

MalaCards organs/tissues related to Benign Meningioma:

40
Brain, Lung, Breast, Spinal Cord, Pineal, Bone, Liver

Publications for Benign Meningioma

Articles related to Benign Meningioma:

(show top 50) (show all 249)
# Title Authors PMID Year
1
Modeling NF2 with human arachnoidal and meningioma cell culture systems: NF2 silencing reflects the benign character of tumor growth. 54 61
17962031 2008
2
Establishment of an in vivo meningioma model with human telomerase reverse transcriptase. 54 61
17415213 2007
3
Protein 4.1B/differentially expressed in adenocarcinoma of the lung-1 functions as a growth suppressor in meningioma cells by activating Rac1-dependent c-Jun-NH(2)-kinase signaling. 54 61
16707455 2006
4
Age associated increase in the prevalence of chromosome 22q loss of heterozygosity in histological subsets of benign meningioma. 54 61
15980114 2006
5
Cathepsins B and L are markers for clinically invasive types of meningiomas. 54 61
11270551 2001
6
Long-term follow up of progesterone receptor status in benign meningioma: a prognostic indicator of recurrence? 54 61
10701525 2000
7
Production of urokinase-type plasminogen activator (u-PA) and plasminogen activator inhibitor-1 (PAI-1) in human brain tumours. 54 61
9689330 1998
8
17 beta-Hydroxysteroid dehydrogenase activity correlates with the type-2 17 beta-hydroxysteroid dehydrogenase mRNA abundance in human meningioma tumors. 54 61
8811669 1996
9
Characterization of 17 beta-hydroxysteroid dehydrogenase activity and mRNA abundance in human meningioma tumors. 54 61
7824086 1994
10
MicroRNA-195 Functions as a Tumor Suppressor by Directly Targeting Fatty Acid Synthase in Malignant Meningioma. 61
31927122 2020
11
Infiltration of Benign Meningioma into Sagittal Sinus and Subsequent Metastasis to Lung: A Case Report and Literature Review. 61
31899401 2019
12
Outcomes of benign meningioma in older patients in the United States. 61
31718937 2019
13
The Prognostic Value of Pretreatment Gallium-68 DOTATATE Positron Emission Tomography/Computed Tomography in Irradiated Non-benign Meningioma. 61
31579356 2019
14
Benign Meningioma With Rare Osteolytic Behavior. 61
31574040 2019
15
Geriatric brain tumor management part I: Meningioma. 61
31208835 2019
16
Challenging the concept that late recurrence and death from tumor are common after fractionated radiotherapy for benign meningioma. 61
31071515 2019
17
Forkhead box M1 (FOXM1) transcription factor is a key oncogenic driver of aggressive human meningioma progression. 61
31179553 2019
18
Risk of benign meningioma after childhood cancer in the DCOG-LATER cohort: contributions of radiation dose, exposed cranial volume, and age. 61
30099534 2019
19
Latency-shift of intra-operative visual evoked potential predicts reversible homonymous hemianopia after intra-ventricular meningioma surgery. 61
31886448 2019
20
A Patient with a Benign and a Malignant Primary Pulmonary Meningioma: An Evaluation with 18F Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography and Computed Tomography with Iodinated Contrast. 61
30713380 2019
21
Giant intercostal nerve schwannoma in a patient with neurofibromatosis type 2. 61
29983103 2018
22
Long-Term Outcomes After Gamma Knife Radiosurgery for Benign Meningioma: A Single Institution's Experience With 424 Patients. 61
29538718 2018
23
Long-term stroke risk of single-fraction photon-based stereotactic radiosurgery for meningioma. 61
30145526 2018
24
Collision Tumor of Glioblastoma and Meningioma: Case Report and Literature Review. 61
29890277 2018
25
Adjuvant postoperative high-dose radiotherapy for atypical and malignant meningioma: A phase-II parallel non-randomized and observation study (EORTC 22042-26042). 61
29960684 2018
26
Ethics and meningiomas: From prudence to obstinacy? The position of the neurosurgeon (for treatment or insurance purposes) in the case of complaints concerning post-operative clinical deterioration. 61
25599871 2018
27
Kinome and phosphoproteome of high-grade meningiomas reveal AKAP12 as a central regulator of aggressiveness and its possible role in progression. 61
29391485 2018
28
Differentiating meningioma grade by imaging features on magnetic resonance imaging. 61
29174756 2018
29
Overexpression of eIF4F components in meningiomas and suppression of meningioma cell growth by inhibiting translation initiation. 61
28610844 2018
30
Incidental Metastatic Meningioma Presenting as a Large Liver Mass. 61
29854500 2018
31
Tumor-to-tumor metastasis: lung adenocarcinoma metastasizing to intracranial benign meningioma as a first clinical manifestation, with literature review. 61
31938406 2018
32
Multimodal treatment of parasagittal meningiomas: a single-center experience. 61
28156245 2017
33
Progression-Free Survival and Factors Associated with Postoperative Recurrence in 126 Patients with Atypical Intracranial Meningioma. 61
28838877 2017
34
Epilepsy and adverse quality of life in surgically resected meningioma. 61
27861722 2017
35
Nuclear spatial and spectral features based evolutionary method for meningioma subtypes classification in histopathology. 61
28379628 2017
36
Tissue thioredoxin-interacting protein expression predicted recurrence in patients with meningiomas. 61
28243945 2017
37
Meningioma with the unique coexistence of secretory and lipomatous components: A case report with immunohistochemical study. 61
28937376 2017
38
Radiation therapy for WHO grade I meningioma. 61
28758408 2017
39
Animal models of meningiomas. 61
28595424 2017
40
Osteolytic Skull Lesions-Our Experience. 61
28694627 2017
41
Recurrent intraventricular meningioma with malignant transformation. 61
28761542 2017
42
Hemangiopericytoma Arose From the Site of Meningioma Resection. 61
28230593 2017
43
Pulmonary metastases from benign calvarial meningioma: a case report. 61
27782754 2017
44
Stereotactic radiosurgery versus fractionated stereotactic radiotherapy in benign meningioma. 61
27815026 2017
45
Fractal Analysis May Improve the Preoperative Identification of Atypical Meningiomas. 61
28173535 2017
46
Analysis of the results of recurrent intracranial meningiomas treated with re-radiosurgery. 61
28081463 2017
47
The role and regulatory mechanism of IL-1β on the methylation of the NF2 gene in benign meningiomas and leptomeninges. 61
26840621 2016
48
Sclerosing Meningioma : Radiological and Clinical Characteristics of 21 Cases. 61
27847571 2016
49
[Traumatic bilateral posterior shoulder dislocation after a seizure]. 61
27908322 2016
50
Clinical and Radiological Characteristics of Angiomatous Meningiomas. 61
27867918 2016

Variations for Benign Meningioma

Expression for Benign Meningioma

Search GEO for disease gene expression data for Benign Meningioma.

Pathways for Benign Meningioma

Pathways related to Benign Meningioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.22 PCNA MDM2 MCM7 CCNA2
2 11.98 PCNA MDM2 MCM7 CCNA2
3 11.82 PCNA MKI67 MDM2 MCM7 CCNA2
4 11.57 PLAU PCNA MDM2
5 11.3 PCNA MKI67 CTSL
6 10.98 PCNA MDM2 CCNA2
7 10.87 PCNA MDM2 MCM7 CCNA2

GO Terms for Benign Meningioma

Cellular components related to Benign Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleolus GO:0005730 9.43 TERT NF2 MKI67 MDM2 MCM7 CTSB
2 endolysosome lumen GO:0036021 8.62 CTSL CTSB

Biological processes related to Benign Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to hydrogen peroxide GO:0070301 9.58 PCNA MDM2 ETS1
2 cellular response to organic cyclic compound GO:0071407 9.54 PTN MDM2 CCNA2
3 cellular response to thyroid hormone stimulus GO:0097067 9.46 CTSL CTSB
4 cellular response to hypoxia GO:0071456 9.46 TERT PTN MDM2 CCNA2
5 negative regulation of glial cell proliferation GO:0060253 9.43 TERT PTN
6 proteolysis involved in cellular protein catabolic process GO:0051603 9.43 MDM2 CTSL CTSB
7 cellular response to xenobiotic stimulus GO:0071466 9.32 PCNA MCM7
8 response to estradiol GO:0032355 9.26 PTN PCNA ETS1 CCNA2
9 estrous cycle GO:0044849 8.8 PTN PCNA ETS1

Molecular functions related to Benign Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.91 TRAF7 TERT SMARCE1 PTN PLAU PGR
2 protein N-terminus binding GO:0047485 9.33 TERT SMARCE1 MDM2
3 proteoglycan binding GO:0043394 8.8 PTN CTSL CTSB

Sources for Benign Meningioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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