MCID: BNG002
MIFTS: 38

Benign Meningioma

Categories: Cancer diseases, Eye diseases, Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Benign Meningioma

MalaCards integrated aliases for Benign Meningioma:

Name: Benign Meningioma 12 54 15 71
Meningioma, Benign 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4587
MeSH 43 D008579
NCIt 49 C4055
UMLS 71 C0281784

Summaries for Benign Meningioma

MalaCards based summary : Benign Meningioma, also known as meningioma, benign, is related to secretory meningioma and spinal meningioma. An important gene associated with Benign Meningioma is NF2 (Neurofibromin 2), and among its related pathways/superpathways are Mitotic G1-G1/S phases and Cell cycle. The drugs Hydroxyurea and Gefitinib have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and breast, and related phenotypes are Increased cell death HMECs cells and Increased shRNA abundance (Z-score > 2)

Related Diseases for Benign Meningioma

Diseases in the Benign Meningioma family:

Meningioma, Familial

Diseases related to Benign Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 82, show less)
# Related Disease Score Top Affiliating Genes
1 secretory meningioma 31.1 TRAF7 NF2 EGFL6
2 spinal meningioma 30.8 TRAF7 SMARCE1 PGR NF2
3 brain meningioma 30.6 TRAF7 NF2
4 meningioma, radiation-induced 30.3 PGR PCNA NF2 MKI67 EPB41L3
5 meningioma, familial 30.2 TRAF7 TERT SMARCE1 PGR PCNA NF2
6 fibrous meningioma 30.0 TRAF7 NF2
7 meningothelial meningioma 29.9 TRAF7 SMARCE1 PGR NF2
8 intraventricular meningioma 29.9 TRAF7 NF2
9 skull base meningioma 29.7 TRAF7 PGR NF2
10 lymphoplasmacyte-rich meningioma 10.7
11 peripheral nerve schwannoma 10.5 SMARCE1 NF2
12 lung meningioma 10.5 PGR NF2
13 polyp of corpus uteri 10.4 PGR NF2
14 rete ovarii adenoma 10.4 PGR NF2
15 rete ovarii neoplasm 10.4 PGR NF2
16 apocrine adenosis of breast 10.4 PGR CCNA2
17 pleomorphic lipoma 10.3 PGR MDM2
18 anaplastic ependymoma 10.3 NF2 MDM2
19 spinal cord ependymoma 10.3 NF2 EPB41L3
20 soft tissue sarcoma 10.3 MKI67 MDM2
21 benign breast phyllodes tumor 10.3 PGR MKI67
22 spinal cord glioma 10.2 NF2 EPB41L3
23 embryonal sarcoma 10.2 MKI67 MDM2
24 cerebral aneurysms 10.2 CTSB CST3
25 angiomatous meningioma 10.2 TRAF7 SMARCE1
26 pediatric meningioma 10.2 TRAF7 NF2
27 spinal cancer 10.2 SMARCE1 PGR NF2 EPB41L3
28 psammomatous meningioma 10.2 TRAF7 NF2
29 anterior cranial fossa meningioma 10.2 TRAF7 NF2
30 intraneural perineurioma 10.1 TRAF7 NF2
31 rhabdoid meningioma 10.1 TRAF7 NF2
32 brain edema 10.1
33 olfactory groove meningioma 10.1 TRAF7 SMARCE1 NF2
34 skull base cancer 10.0 TRAF7 PGR NF2
35 lymphangiomatosis 10.0 PGR PCNA
36 neurofibromatosis, type iv, of riccardi 10.0
37 hydrops, lactic acidosis, and sideroblastic anemia 10.0
38 frontal convexity meningioma 10.0 TRAF7 TERT NF2
39 melanotic neuroectodermal tumor 10.0 MDM2 CCNA2
40 bizarre leiomyoma 10.0 PGR PCNA
41 gastrointestinal stromal tumor 9.9 NF2 MKI67 CTSL CCNA2
42 bowen's disease 9.9 PCNA MKI67
43 aortic aneurysm, familial abdominal, 1 9.9 PLAU CTSL CST3
44 ovarian endometrial cancer 9.9 PGR CTSB
45 hemangiopericytoma, malignant 9.9
46 tinea capitis 9.9
47 pulmonary coin lesion 9.9
48 dermatophytosis 9.9
49 rare surgical neurologic disease 9.9
50 spinal canal and spinal cord meningioma 9.9 TRAF7 SMARCE1 PGR NF2
51 transitional meningioma 9.9 TRAF7 SMARCE1 PGR NF2
52 oral leukoplakia 9.9 PCNA MKI67
53 bladder adenocarcinoma 9.8 PCNA MKI67
54 juvenile nasopharyngeal angiofibroma 9.8 PGR PCNA
55 gliosarcoma 9.8 TERT MDM2 CTSB
56 neurofibromatosis, type ii 9.8
57 cerebral amyloid angiopathy, cst3-related 9.8
58 pituitary hormone deficiency, combined, 2 9.8
59 ataxia and polyneuropathy, adult-onset 9.8
60 lung cancer susceptibility 3 9.8
61 fibrous dysplasia 9.8
62 hydrocephalus 9.8
63 optic nerve disease 9.8
64 blepharospasm 9.8
65 optic nerve sheath meningioma 9.8
66 pineal region meningioma 9.8
67 hypopituitarism 9.8
68 47,xyy 9.8
69 glioma 9.8
70 encephalopathy 9.8
71 headache 9.8
72 glial tumor 9.8
73 monosomy 22 9.8
74 clonorchiasis 9.7 CTSL CTSB
75 leiomyoma 9.7 PGR PCNA MKI67
76 clear cell meningioma 9.7 TRAF7 SMARCE1 PGR NF2 MKI67
77 breast adenocarcinoma 9.7 PLAU PGR CTSB CCNA2
78 uterine carcinosarcoma 9.6 PGR PCNA MKI67
79 bladder urothelial carcinoma 9.5 TERT PCNA MKI67 MDM2
80 pancreatic adenocarcinoma 9.3 TERT PLAU MIA2 MDM2 CTSB CCNA2
81 grade iii astrocytoma 9.2 PLAU PCNA MDM2 CTSB
82 endometrial cancer 8.7 TERT PLAU PGR PCNA MKI67 MDM2

Graphical network of the top 20 diseases related to Benign Meningioma:



Diseases related to Benign Meningioma

Symptoms & Phenotypes for Benign Meningioma

GenomeRNAi Phenotypes related to Benign Meningioma according to GeneCards Suite gene sharing:

26 (showing 23, show less)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death HMECs cells GR00103-A-0 9.76 CCNA2 CTSB CTSL MCM7 MDM2 PCNA
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.72 CTSB
3 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.72 CTSB MDM2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.72 SMARCE1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.72 EGFL6
6 Increased shRNA abundance (Z-score > 2) GR00366-A-13 9.72 CTSB
7 Increased shRNA abundance (Z-score > 2) GR00366-A-136 9.72 MDM2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.72 EGFL6
9 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.72 MDM2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.72 MDM2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.72 CTSB
12 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.72 MDM2 SMARCE1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.72 SMARCE1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.72 CTSB
15 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.72 EGFL6
16 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.72 CTSB EGFL6 MDM2 SMARCE1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.72 EGFL6
18 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.72 SMARCE1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.72 MDM2
20 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.72 MDM2
21 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.72 SMARCE1
22 Increased Nanog expression GR00371-A-1 9.35 MCM7 MKI67 PCNA SMARCE1
23 Increased Nanog expression GR00371-A-2 9.35 SMARCE1

MGI Mouse Phenotypes related to Benign Meningioma:

45 (showing 6, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.07 CST3 CTSB EPB41L3 ETS1 MDM2 NF2
2 mortality/aging MP:0010768 10.07 CCNA2 CST3 CTSB EPB41L3 ETS1 MCM7
3 immune system MP:0005387 10.06 CCNA2 CTSB ETS1 MDM2 NF2 PCNA
4 neoplasm MP:0002006 9.76 CST3 CTSB EPB41L3 MDM2 NF2 PGR
5 normal MP:0002873 9.56 CTSB EGFL6 EPB41L3 HSD17B13 MDM2 MKI67
6 reproductive system MP:0005389 9.28 CST3 EPB41L3 MDM2 NF2 PCNA PGR

Drugs & Therapeutics for Benign Meningioma

Drugs for Benign Meningioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 3, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydroxyurea Approved Phase 2 127-07-1 3657
2
Gefitinib Approved, Investigational Phase 2 184475-35-2 123631
3 Protein Kinase Inhibitors Phase 2

Interventional clinical trials:

(showing 5, show less)
# Name Status NCT ID Phase Drugs
1 Prospective Study Of Patients With Recurrent Or Incomplete Excised Benign Intercranial Meningiomas For The Evaluation Of Treatment Result With Combined Proton And Photon Irradiation To Doses 55.8 Or 63.0 CGE Completed NCT02947984 Phase 3
2 Observation Versus Conventional-Fractionated Radiotherapy or Radiosurgery After Non-radical Surgery for Benign Intracranial Meningiomas: A Phase III Study Terminated NCT00104936 Phase 3
3 Phase II Study of Hydroxyurea for Unresectable Meningioma Completed NCT00003590 Phase 2 hydroxyurea
4 ZD1839 FOR Treatment Of Recurrent Or Progressive Malignant Astrocytoma Or Glioblastoma And Recurrent Or Progressive Meningioma: A Phase II Study With A Phase I Component For Patients Receiving EIAEDs Completed NCT00025675 Phase 2 gefitinib
5 Multisession Radiosurgery in Large Meningiomas Active, not recruiting NCT02974127

Search NIH Clinical Center for Benign Meningioma

Genetic Tests for Benign Meningioma

Anatomical Context for Benign Meningioma

MalaCards organs/tissues related to Benign Meningioma:

40
Brain, Lung, Breast, Spinal Cord, Pineal, Bone, Liver

Publications for Benign Meningioma

Articles related to Benign Meningioma:

(showing 249, show less)
# Title Authors PMID Year
1
Modeling NF2 with human arachnoidal and meningioma cell culture systems: NF2 silencing reflects the benign character of tumor growth. 54 61
17962031 2008
2
Establishment of an in vivo meningioma model with human telomerase reverse transcriptase. 54 61
17415213 2007
3
Protein 4.1B/differentially expressed in adenocarcinoma of the lung-1 functions as a growth suppressor in meningioma cells by activating Rac1-dependent c-Jun-NH(2)-kinase signaling. 54 61
16707455 2006
4
Age associated increase in the prevalence of chromosome 22q loss of heterozygosity in histological subsets of benign meningioma. 54 61
15980114 2006
5
Cathepsins B and L are markers for clinically invasive types of meningiomas. 54 61
11270551 2001
6
Long-term follow up of progesterone receptor status in benign meningioma: a prognostic indicator of recurrence? 54 61
10701525 2000
7
Production of urokinase-type plasminogen activator (u-PA) and plasminogen activator inhibitor-1 (PAI-1) in human brain tumours. 54 61
9689330 1998
8
17 beta-Hydroxysteroid dehydrogenase activity correlates with the type-2 17 beta-hydroxysteroid dehydrogenase mRNA abundance in human meningioma tumors. 54 61
8811669 1996
9
Characterization of 17 beta-hydroxysteroid dehydrogenase activity and mRNA abundance in human meningioma tumors. 54 61
7824086 1994
10
MicroRNA-195 Functions as a Tumor Suppressor by Directly Targeting Fatty Acid Synthase in Malignant Meningioma. 61
31927122 2020
11
Infiltration of Benign Meningioma into Sagittal Sinus and Subsequent Metastasis to Lung: A Case Report and Literature Review. 61
31899401 2019
12
Outcomes of benign meningioma in older patients in the United States. 61
31718937 2019
13
The Prognostic Value of Pretreatment Gallium-68 DOTATATE Positron Emission Tomography/Computed Tomography in Irradiated Non-benign Meningioma. 61
31579356 2019
14
Benign Meningioma With Rare Osteolytic Behavior. 61
31574040 2019
15
Geriatric brain tumor management part I: Meningioma. 61
31208835 2019
16
Challenging the concept that late recurrence and death from tumor are common after fractionated radiotherapy for benign meningioma. 61
31071515 2019
17
Forkhead box M1 (FOXM1) transcription factor is a key oncogenic driver of aggressive human meningioma progression. 61
31179553 2019
18
Risk of benign meningioma after childhood cancer in the DCOG-LATER cohort: contributions of radiation dose, exposed cranial volume, and age. 61
30099534 2019
19
Latency-shift of intra-operative visual evoked potential predicts reversible homonymous hemianopia after intra-ventricular meningioma surgery. 61
31886448 2019
20
A Patient with a Benign and a Malignant Primary Pulmonary Meningioma: An Evaluation with 18F Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography and Computed Tomography with Iodinated Contrast. 61
30713380 2019
21
Giant intercostal nerve schwannoma in a patient with neurofibromatosis type 2. 61
29983103 2018
22
Long-Term Outcomes After Gamma Knife Radiosurgery for Benign Meningioma: A Single Institution's Experience With 424 Patients. 61
29538718 2018
23
Long-term stroke risk of single-fraction photon-based stereotactic radiosurgery for meningioma. 61
30145526 2018
24
Collision Tumor of Glioblastoma and Meningioma: Case Report and Literature Review. 61
29890277 2018
25
Adjuvant postoperative high-dose radiotherapy for atypical and malignant meningioma: A phase-II parallel non-randomized and observation study (EORTC 22042-26042). 61
29960684 2018
26
Ethics and meningiomas: From prudence to obstinacy? The position of the neurosurgeon (for treatment or insurance purposes) in the case of complaints concerning post-operative clinical deterioration. 61
25599871 2018
27
Kinome and phosphoproteome of high-grade meningiomas reveal AKAP12 as a central regulator of aggressiveness and its possible role in progression. 61
29391485 2018
28
Differentiating meningioma grade by imaging features on magnetic resonance imaging. 61
29174756 2018
29
Overexpression of eIF4F components in meningiomas and suppression of meningioma cell growth by inhibiting translation initiation. 61
28610844 2018
30
Incidental Metastatic Meningioma Presenting as a Large Liver Mass. 61
29854500 2018
31
Tumor-to-tumor metastasis: lung adenocarcinoma metastasizing to intracranial benign meningioma as a first clinical manifestation, with literature review. 61
31938406 2018
32
Multimodal treatment of parasagittal meningiomas: a single-center experience. 61
28156245 2017
33
Progression-Free Survival and Factors Associated with Postoperative Recurrence in 126 Patients with Atypical Intracranial Meningioma. 61
28838877 2017
34
Epilepsy and adverse quality of life in surgically resected meningioma. 61
27861722 2017
35
Nuclear spatial and spectral features based evolutionary method for meningioma subtypes classification in histopathology. 61
28379628 2017
36
Tissue thioredoxin-interacting protein expression predicted recurrence in patients with meningiomas. 61
28243945 2017
37
Meningioma with the unique coexistence of secretory and lipomatous components: A case report with immunohistochemical study. 61
28937376 2017
38
Radiation therapy for WHO grade I meningioma. 61
28758408 2017
39
Animal models of meningiomas. 61
28595424 2017
40
Osteolytic Skull Lesions-Our Experience. 61
28694627 2017
41
Recurrent intraventricular meningioma with malignant transformation. 61
28761542 2017
42
Hemangiopericytoma Arose From the Site of Meningioma Resection. 61
28230593 2017
43
Pulmonary metastases from benign calvarial meningioma: a case report. 61
27782754 2017
44
Stereotactic radiosurgery versus fractionated stereotactic radiotherapy in benign meningioma. 61
27815026 2017
45
Fractal Analysis May Improve the Preoperative Identification of Atypical Meningiomas. 61
28173535 2017
46
Analysis of the results of recurrent intracranial meningiomas treated with re-radiosurgery. 61
28081463 2017
47
The role and regulatory mechanism of IL-1β on the methylation of the NF2 gene in benign meningiomas and leptomeninges. 61
26840621 2016
48
Sclerosing Meningioma : Radiological and Clinical Characteristics of 21 Cases. 61
27847571 2016
49
[Traumatic bilateral posterior shoulder dislocation after a seizure]. 61
27908322 2016
50
Clinical and Radiological Characteristics of Angiomatous Meningiomas. 61
27867918 2016
51
Review of controversies in management of non-benign meningioma. 61
27338209 2016
52
The role of diffusion tensor imaging and dynamic susceptibility perfusion MRI in the evaluation of meningioma grade and subtype. 61
27208870 2016
53
Acute Progression of Recurrent Meningioma during Luteinizing Hormone-Releasing Hormone Agonist Treatment for Prostate Cancer. 61
27046016 2016
54
Invasive benign meningioma: Clinical characteristics, surgical strategies and outcomes from a single neurosurgical institute. 61
27284345 2016
55
Correlations of magnetic resonance, perfusion-weighed imaging parameters and microvessel density in meningioma. 61
27569094 2016
56
Iatrogenic Seeding of Tumor Cells in Thigh Soft Tissue Upon Surgical Removal of Intracranial Meningioma. 61
27303610 2016
57
The neglected need for psychological intervention in patients suffering from incidentally discovered intracranial aneurysms. 61
26896784 2016
58
Cerebral amyloid angiopathy-related infarcts imitating high-grade differentiation of a benign meningioma. 61
26385916 2015
59
Development of patient-derived xenograft models from a spontaneously immortal low-grade meningioma cell line, KCI-MENG1. 61
26174772 2015
60
[Foramen magunum meningioma presented as subarachnoid haemorrhage]. 61
25926541 2015
61
A case of benign meningioma presented with subdural hemorrhage. 61
25977904 2015
62
An incidental pulmonary meningioma revealing an intracranial meningioma: primary or secondary lesion? 61
25841855 2015
63
Benign Sacral Metastatic Meningioma: A Rare Entity. 61
26130988 2015
64
Detection of human cytomegalovirus in different histopathological types of glioma in Iraqi patients. 61
25710012 2015
65
Diagnosis value of membrane glycolipids biochemistry index in intracranial and gastrointestinal tumors. 61
25854348 2015
66
A new texture and shape based technique for improving meningioma classification. 61
25060536 2014
67
Is progesteron receptor status really a prognostic factor for intracranial meningiomas? 61
25036873 2014
68
Stereotactic radiation therapy for benign meningioma: long-term outcome in 318 patients. 61
24751409 2014
69
Stereotactic radiotherapy of benign meningioma in the elderly: clinical outcome and toxicity in 121 patients. 61
24813096 2014
70
The rim pattern of meningioma on 3D FLAIR imaging: correlation with tumor-brain adhesion and histological grading. 61
25167879 2014
71
A retrospective analysis of survival and prognostic factors after stereotactic radiosurgery for aggressive meningiomas. 61
24467972 2014
72
Biochemical markers of brain tumours. 61
24640102 2013
73
The expression of fatty acid metabolism-associated proteins is correlated with the prognosis of meningiomas. 61
23879478 2013
74
Natural compounds as potential treatments of NF2-deficient schwannoma and meningioma: cucurbitacin D and goyazensolide. 61
23928514 2013
75
Brain meningioma in a patient with complaints of low back pain and leg weakness. 61
23126500 2013
76
Prospective evaluation of early treatment outcome in patients with meningiomas treated with particle therapy based on target volume definition with MRI and 68Ga-DOTATOC-PET. 61
23402336 2013
77
The transmembrane chemokines CXCL16 and CX3CL1 and their receptors are expressed in human meningiomas. 61
23229614 2013
78
Protein expression profiling of brain tumor tissue using SELDI-MS. 61
23765628 2013
79
Gamma knife stereotactic radiosurgery for atypical and malignant meningiomas. 61
23417463 2013
80
Management of non-benign meningiomas with Gamma Knife radiosurgery. 61
23417464 2013
81
High incidence of benign brain meningiomas among Iranian- born Jews in Israel may be linked to both hereditary and environmental factors. 61
24289623 2013
82
Gene expression profiles of metabolic aggressiveness and tumor recurrence in benign meningioma. 61
23840654 2013
83
Histone deacetylase inhibitor AR-42 differentially affects cell-cycle transit in meningeal and meningioma cells, potently inhibiting NF2-deficient meningioma growth. 61
23151902 2013
84
Granulofilamentous meningioma. 61
22382610 2013
85
Human brain cancer studied by resonance Raman spectroscopy. 61
23154776 2012
86
Projected second tumor risk and dose to neurocognitive structures after proton versus photon radiotherapy for benign meningioma. 61
22285662 2012
87
An unusual bump on the head. Intraextracranial meningioma presenting incidentally. 61
22744251 2012
88
Impaired survival and long-term neurological problems in benign meningioma. 61
22406926 2012
89
[Transzygomatic pterional approach. Part 2: Surgical experience in the management of skull base pathology]. 61
22613467 2012
90
Living in a paradox--women's experiences of body and life-world after meningioma surgery. 61
21834839 2012
91
Extra cranial invasive meningioma of fronto-temporo-parietal region of the skull vault. 61
22665563 2012
92
Incidental finding of meningioma on C11-PIB PET. 61
22228363 2012
93
Analysis of gene expression profiling in meningioma: deregulated signaling pathways associated with meningioma and EGFL6 overexpression in benign meningioma tissue and serum. 61
23285163 2012
94
Meningeal Hemangiopericytoma with Intracranial Metastases in an HIV-Positive Male: Case Report and Review of the Literature. 61
22666206 2012
95
Gamma knife radiosurgery in the treatment of tumor-related facial pain. 61
22508112 2012
96
Granulomatous inflammation of dura mater--a rare side effect after application of hemostatic and insulation materials in case of two-stage operation of huge meningioma. 61
23319199 2012
97
Stereotactic radiosurgery and radiotherapy for meningiomas: biomarker predictors of patient outcome and response to therapy. 61
29296341 2012
98
Brain meningioma invading and destructing the skull bone: replacement of the missing bone in vivo. 61
22933971 2011
99
Integrative genomic analysis identifies CCNB1 and CDC2 as candidate genes associated with meningioma recurrence. 61
22137483 2011
100
High resolution genomic profiling and classical cytogenetics in a group of benign and atypical meningiomas. 61
22137484 2011
101
Extramedullary spinal ependymoma: a diagnostic challenge and review of the literature. 61
21435777 2011
102
AR42, a novel histone deacetylase inhibitor, as a potential therapy for vestibular schwannomas and meningiomas. 61
21778190 2011
103
Is a benign meningioma always an indolent tumor? 61
21486754 2011
104
Coexistence of intracranial meningioma, pulmonary meningiomas, and lung cancer. 61
21440166 2011
105
Long-term outcomes of fractionated stereotactic radiotherapy for intracranial skull base benign meningiomas in single institution. 61
21177777 2011
106
Multiple primary malignancies and subtle mucocutaneous lesions associated with a novel PTEN gene mutation in a patient with Cowden syndrome: case report. 61
21406108 2011
107
Third ventricular meningioma--case report. 61
21273752 2011
108
Susceptibility to 5-aminolevulinic acid based photodynamic therapy in WHO I meningioma cells corresponds to ferrochelatase activity. 61
21073472 2011
109
Osteopontin expression is a valuable marker for prediction of short-term recurrence in WHO grade I benign meningiomas. 61
20428925 2010
110
Metabolic aggressiveness in benign meningiomas with chromosomal instabilities. 61
20861191 2010
111
Coexistence between meningioma and tuberculosis: case report. 61
20195701 2010
112
Quantitative evaluation of benign meningioma and hemangiopericytoma with peritumoral brain edema by 64-slice CT perfusion imaging. 61
20819539 2010
113
Patterns of failure after stereotactic radiotherapy of intracranial meningioma. 61
20012910 2010
114
Tumor-to-tumor metastasis from hematopoietic neoplasms to meningiomas: report of two patients with significant cerebral edema. 61
21300009 2010
115
Loss of heterozygosity at 1p, 7q, 17p, and 22q in meningiomas. 61
20717507 2010
116
Rare growth of a psammomatous meningioma in a mature ovarian teratoma: a case report. 61
19616897 2010
117
Heterozygous TP53stop146/R72P fibroblasts from a Li-Fraumeni syndrome patient with impaired response to DNA damage. 61
20198344 2010
118
Possible role of matrix metalloproteinase in osteolytic intracranial meningiomas. 61
20157372 2010
119
Comparative PET study using F-18 FET and F-18 FDG for the evaluation of patients with suspected brain tumour. 61
20004582 2010
120
Microarray gene expression profiling in meningiomas: differential expression according to grade or histopathological subtype. 61
19885562 2009
121
Benign meningioma developing late lung metastases: case report and review of the literature. 61
19919820 2009
122
A case of cerebellopontine angle meningioma presenting with neck and upper extremity pain. 61
20004806 2009
123
How a Brain Tumour took over my Life: Diagnosis and removal of a benign meningioma. 61
21509301 2009
124
Advances in meningioma therapy. 61
19348712 2009
125
Rapid growth of small, asymptomatic meningioma following radiosurgery. 61
19306181 2009
126
Meningiomas and schwannomas: molecular subgroup classification found by expression arrays. 54
19148485 2009
127
Multiple extracranial metastases of atypical meningiomas. 61
19274122 2009
128
Epidemiology of primary brain tumors in the Middle Eastern population in California, USA 2001-2005. 61
19588542 2009
129
Ectopic meningioma anterior to the lacrimal gland fossa. 61
19273931 2009
130
Lipid signal in evaluation of intracranial meningiomas. 61
19102960 2008
131
Crush preparations of meningiomas: can grading be accomplished? 61
18831022 2008
132
Benign and atypical meningioma metabolic signatures by high-resolution magic-angle spinning molecular profiling. 61
18507434 2008
133
Histologically benign intraventricular meningioma with concurrent pulmonary metastasis: case report and review of the literature. 61
18282656 2008
134
A 72-year-old woman with right frontal extra-axial mass. 61
18363938 2008
135
SU11657 enhances radiosensitivity of human meningioma cells. 61
18234428 2008
136
Angiomatous meningioma: a diagnostic dilemma. 61
18417856 2008
137
Iatrogenic metastasis of a benign meningioma to the periosteum at the site of previous craniotomy: a case report. 61
19122989 2008
138
Characterization of complex chromosome aberrations in a recurrent meningioma combining standard cytogenetic and array comparative genomic hybridization techniques. 61
18068535 2008
139
Myelin structure is a key difference in the x-ray scattering signature between meningioma, schwannoma and glioblastoma multiforme. 61
17951861 2007
140
Gamma Knife surgery for benign meningioma. 61
17695387 2007
141
"Benign" metastatic meningioma: clinico-pathological analysis of one case metastasising to the lung and overview on the concepts of either primitive or metastatic meningiomas of the lung. 61
17431673 2007
142
Progression of astrocytomas and meningiomas: an evaluation in vitro. 54
17227292 2007
143
Increased expression of avian erythroblastosis virus E26 oncogene homolog 1 in World Health Organization grade 1 meningiomas is associated with an elevated risk of recurrence and is correlated with the expression of its target genes matrix metalloproteinase-2 and MMP-9. 54
16894529 2006
144
Somnolence syndrome after focal radiation therapy to the pineal region: case report and review of the literature. 61
16575537 2006
145
Metastatic meningioma to the eleventh dorsal vertebral body: total en bloc spondylectomy. Case report and review of the literature. 61
16855782 2006
146
PCNA, Ki-67 and hTERT in residual benign meningiomas. 54
16634530 2006
147
Positron emission tomography elucidates transport system and tumor proliferation in meningiomas. 54
16142342 2005
148
Diagnosis and treatment of atypical and anaplastic meningiomas: a review. 61
16145534 2005
149
Establishment of a benign meningioma cell line by hTERT-mediated immortalization. 61
15965488 2005
150
[Hemangiopericytoma at the transverse sinus presenting with intracerebral hemorrhage: case report]. 61
16164186 2005
151
Intracranial collision tumor mimicking an octreotide-SPECT positive and FDG-PET negative meningioma. 61
16115558 2005
152
Functional outcome of patients with benign meningioma treated by 3D conformal irradiation with a combination of photons and protons. 61
16029801 2005
153
Proliferation and progesterone receptor status in benign meningiomas are not age dependent. 54
15952201 2005
154
High throughput screening of meningioma biomarkers using a tissue microarray. 54
15980972 2005
155
Tissue plasminogen activator expression in meningiomas and glioblastomas. 61
15885387 2005
156
Edema and malignancy in meningiomas. 61
15962080 2005
157
Cathepsins B and L and their inhibitors stefin B and cystatin C as markers for malignant progression of benign meningiomas. 54
15832773 2005
158
Increased expression of aquaporin-4 in human traumatic brain injury and brain tumors. 61
15593389 2005
159
p53 point mutation is rare in meningiomas from Singaporean patients. 61
15691789 2005
160
Major venous sinus resection in the surgical treatment of recurrent aggressive dural based tumors. 61
15576120 2004
161
Dose fractionation in stereotactic radiotherapy for parasellar meningiomas: radiobiological considerations of efficacy and optic nerve tolerance. 61
15537194 2004
162
Coexpression of hepatocyte growth factor/scatter factor (HGF/SF) and its receptor cMET predict recurrence of meningiomas. 61
15312691 2004
163
Heparin affin regulatory peptide: a new target for tumour therapy? 54
15379633 2004
164
Hormone receptors in benign intracranial meningiomas. 54
17415829 2004
165
Radiotherapy after surgery for benign cerebral meningioma. 61
15066300 2004
166
[Brain tumors in the elderly]. 61
15683966 2004
167
Expression of the inhibitor of apoptosis protein survivin in benign meningiomas. 54
12706880 2003
168
Prognostic significance of cyclin a expression in meningiomas. 54
12610350 2003
169
Benign metastasizing meningioma. 61
12629059 2003
170
[Early recurrent meningioma with malignant transformation: case report]. 61
12616654 2003
171
Biphasic malignant meningioma: a comparative genomic hybridization study. 61
12489674 2002
172
[Intracerebral radiotherapy under stereotaxic conditions]. 61
12587393 2002
173
Overexpression of mdm2 and p53 and association with progesterone receptor expression in benign meningiomas. 54
12416559 2002
174
Benign meningioma metastasizing through CSF pathways: a case report and review of literature. 61
12391463 2002
175
Stabilization of disease progression by hydroxyurea in patients with recurrent or unresectable meningioma. 61
12186462 2002
176
Intensity-modulated radiation therapy (IMRT) for meningioma. 61
12128128 2002
177
[Comparative assessment of the diagnostic capacities of PET with 18FDG and 1-[11C] sodium butyrate in the examination of patients with tumors of the brain and cerebral circulatory disorders: results of semiquantitative assessment]. 61
12577659 2002
178
The impact of progesterone receptor expression on relapse in the long-term clinical course of 93 benign meningiomas. 54
12224136 2002
179
A novel germline mutation of PTEN associated with brain tumours of multiple lineages. 61
12085208 2002
180
Immunohistochemical detection of progesterone receptors and the correlation with Ki-67 labeling indices in paraffin-embedded sections of meningiomas. 54
12325398 2002
181
Stromelysin-3 is expressed by aggressive meningiomas. 61
11857311 2002
182
[Metastatic meningioma to the first thoracic vertebral body. A case report and review of the literature]. 61
11972153 2002
183
Early recurrence of benign meningioma correlates with expression of mini-chromosome maintenance-2 protein. 61
11928726 2002
184
Progesterone receptors are expressed with higher frequency by optic nerve sheath meningiomas. 54
11846045 2002
185
['Benign' meningioma]. 61
11727610 2001
186
Expression of multiple larger-sized transcripts for several genes in oligodendrogliomas: potential markers for glioma subtype. 61
11485829 2001
187
Alterations of the tumor suppressor genes CDKN2A (p16(INK4a)), p14(ARF), CDKN2B (p15(INK4b)), and CDKN2C (p18(INK4c)) in atypical and anaplastic meningiomas. 61
11485924 2001
188
Long-term results of stereotactic gamma radiosurgery of meningiomas. 61
11483185 2001
189
[Role of radiotherapy in the treatment of cerebral meningiomas]. 61
11446076 2001
190
Different distribution of c-myc and MIB-1 positive cells in malignant meningiomas with reference to TGFs, PDGF, and PgR expression. 54
11517968 2001
191
Different responses of benign and atypical meningiomas to gamma-knife radiosurgery: report of two cases with immunohistochemical analysis. 61
11908875 2001
192
Expression of androgen receptor in meningiomas. 54
11523220 2001
193
Immunohistochemical expression of Ets-1 transcription factor and the urokinase-type plasminogen activator is correlated with the malignant and invasive potential in meningiomas. 54
11147600 2000
194
Benign meningioma: partially resected, biopsied, and recurrent intracranial tumors treated with combined proton and photon radiotherapy. 61
11121635 2000
195
An iatrogenic epidemic of benign meningioma. 61
10670551 2000
196
Intracranial injection of human meningioma cells in athymic mice: an orthotopic model for meningioma growth. 61
10659019 2000
197
The effects of exogenous growth factors on matrix metalloproteinase secretion by human brain tumour cells. 61
10638966 2000
198
p53 and PCNA expression in benign, atypical and malignant meningiomas. 54
10647228 1999
199
Images in pathology. Benign meningioma. 61
10458841 1999
200
Radiotherapy in the treatment of benign meningioma of the skull base. 61
10223446 1999
201
Role of p53 gene mutation in tumor aggressiveness of intracranial meningiomas. 61
10331568 1999
202
[Radiation-induced meningioma 20 years after operation and high-dose irradiation of an ependymoma]. 61
10356722 1999
203
Hemangiopericytoma arising at the site of a dural graft 13 years after total removal of a benign meningioma--case report. 61
9919906 1998
204
DNA ploidy and cell-cycle analysis in intracranial meningiomas and hemangiopericytomas: a study with high-resolution DNA flow cytometry. 61
9583723 1998
205
Prediction of recurrence in histologically benign meningiomas: proliferating cell nuclear antigen and Ki-67 immunohistochemical study. 54
9352816 1997
206
No prediction of recurrence of meningiomas by PCNA and Ki-67 immunohistochemistry. 54
9258816 1997
207
Effect of glucocorticoids on ICP in patients with a cerebral tumour. 61
9300070 1997
208
Primary intraosseous meningiomas of the skull. 61
9240709 1997
209
Correlation of histopathologic classification with proliferative activity and DNA ploidy in 120 intracranial meningiomas, with special reference to atypical meningioma. 54
9250918 1997
210
Primary pulmonary meningioma: report of a case and review of the literature. 61
9130993 1997
211
Radiosurgical treatment of meningiomas. 61
9711750 1997
212
Quantification of low-velocity motion using a navigator-echo supported MR velocity-mapping technique: application to intracranial dynamics in volunteers and patients with brain tumours. 61
9084019 1997
213
Expression of cysteine protease inhibitors in human gliomas and meningiomas. 61
8878408 1996
214
Primary cavernous sinus malignant lymphoma treated by gamma knife radiosurgery: case report and review of the literature. 61
8781598 1996
215
[X-ray computed tomographic aspects of malignant meningioma and meningeal hemangiopericytoma]. 61
8696997 1996
216
[On diagnostics of malignant meningioma and invasive meningioma]. 61
9389041 1996
217
Excess of rare cancers in Werner syndrome (adult progeria). 61
8722214 1996
218
Prognostic significance of nuclear DNA content in human meningiomas: a prospective study. 61
8738500 1996
219
[Radiotherapy for intracranial meningioma: special reference to malignant and high risk benign meningioma]. 61
8587846 1995
220
TGF alpha expression in meningioma--tumor progression and therapeutic response. 61
8583244 1995
221
Evidence of meningioma infiltration into cranial nerves: clinical implications for cavernous sinus meningiomas. 61
7545742 1995
222
[Benign meningioma following scalp irradiation in north African immigrants]. 61
7557660 1995
223
Tumors in Rubinstein-Taybi syndrome. 61
7747773 1995
224
Plasminogen activator inhibitor-1 in brain tumors: relation to malignancy and necrosis. 61
7731519 1995
225
Meningiomas and gliomas in juxtaposition: casual or causal coexistence? Report of two cases. 61
7802136 1995
226
[The pulmonary metastasis of a benign meningioma]. 61
8025804 1994
227
Immunohistochemical expression of proliferating cell nuclear antigen (PCNA) in intracranial glioma and meningioma. 61
7911730 1994
228
The significance of nucleolar organizer region (AgNOR) score in predicting meningioma recurrence. 61
8156526 1994
229
Postoperative irradiation for subtotally resected meningiomas. A retrospective analysis of 140 patients treated from 1967 to 1990. 61
8283256 1994
230
Correlation between histopathology and linoleic acid levels in five meningioma types. 61
8321745 1993
231
Benign meningioma with a short latency period following irradiation. 61
1440212 1992
232
The new growth factor pleiotrophin (HB-GAM) mRNA is selectively present in the meningothelial cells of human meningiomas. 54
1407714 1992
233
The role of radiotherapy in the treatment of subtotally resected benign meningiomas. 61
1432033 1992
234
MRI of aggressive meningiomas. 61
1564530 1992
235
Treatment of unresectable meningiomas with the antiprogesterone agent mifepristone. 61
2033444 1991
236
[Bone and lung metastasis from recurrent benign meningioma]. 61
2148386 1990
237
Meningioma following high-dose radiation therapy. Case report and review of the literature. 61
1963827 1990
238
Elevated expression of basic fibroblast growth factor messenger ribonucleic acid in acoustic neuromas. 61
2710130 1989
239
Will chromosome karyotyping of meningiomas aid prediction of tumour recurrence? 61
2818850 1989
240
DNA-determination in the clinical management of patients with meningioma or haemangioblastoma. 61
2818849 1989
241
Immunocytochemical study of the cellular immune response in meningiomas. 61
3258871 1988
242
Metastatic spread of benign intracranial meningioma. 61
3625286 1987
243
The value of radiation therapy as an adjuvant to surgery in intracranial meningiomas. 61
3751972 1986
244
[A case of multiple extracranial meningiomas]. 61
4068244 1985
245
Radiation therapy in the treatment of meningioma: the Joint Center for Radiation Therapy experience 1970 to 1982. 61
6491698 1984
246
Carcinoma of the breast and meningioma. Association and management. 61
6831359 1983
247
[Retroauricular tumefaction disclosing a histologically benign meningioma]. 61
7063799 1982
248
Meningioma after contralateral hemispherectomy for malignant glioma: case report. 61
1151416 1975
249
Histological subtypes and prognostic problems in meningiomas. 61
50413 1975

Variations for Benign Meningioma

Expression for Benign Meningioma

Search GEO for disease gene expression data for Benign Meningioma.

Pathways for Benign Meningioma

Pathways related to Benign Meningioma according to GeneCards Suite gene sharing:

(showing 7, show less)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.22 PCNA MDM2 MCM7 CCNA2
2 11.98 PCNA MDM2 MCM7 CCNA2
3 11.82 PCNA MKI67 MDM2 MCM7 CCNA2
4 11.57 PLAU PCNA MDM2
5 11.3 PCNA MKI67 CTSL
6 10.98 PCNA MDM2 CCNA2
7 10.87 PCNA MDM2 MCM7 CCNA2

GO Terms for Benign Meningioma

Cellular components related to Benign Meningioma according to GeneCards Suite gene sharing:

(showing 2, show less)
# Name GO ID Score Top Affiliating Genes
1 nucleolus GO:0005730 9.43 TERT NF2 MKI67 MDM2 MCM7 CTSB
2 endolysosome lumen GO:0036021 8.62 CTSL CTSB

Biological processes related to Benign Meningioma according to GeneCards Suite gene sharing:

(showing 9, show less)
# Name GO ID Score Top Affiliating Genes
1 cellular response to hydrogen peroxide GO:0070301 9.58 PCNA MDM2 ETS1
2 cellular response to organic cyclic compound GO:0071407 9.54 PTN MDM2 CCNA2
3 cellular response to thyroid hormone stimulus GO:0097067 9.46 CTSL CTSB
4 cellular response to hypoxia GO:0071456 9.46 TERT PTN MDM2 CCNA2
5 negative regulation of glial cell proliferation GO:0060253 9.43 TERT PTN
6 proteolysis involved in cellular protein catabolic process GO:0051603 9.43 MDM2 CTSL CTSB
7 cellular response to xenobiotic stimulus GO:0071466 9.32 PCNA MCM7
8 response to estradiol GO:0032355 9.26 PTN PCNA ETS1 CCNA2
9 estrous cycle GO:0044849 8.8 PTN PCNA ETS1

Molecular functions related to Benign Meningioma according to GeneCards Suite gene sharing:

(showing 3, show less)
# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.91 TRAF7 TERT SMARCE1 PTN PLAU PGR
2 protein N-terminus binding GO:0047485 9.33 TERT SMARCE1 MDM2
3 proteoglycan binding GO:0043394 8.8 PTN CTSL CTSB

Sources for Benign Meningioma

3 CDC
7 CNVD
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11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
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30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
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35 IUPHAR
36 KEGG
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61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
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72 UMLS via Orphanet
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