MCID: BNG032
MIFTS: 42

Benign Mesothelioma

Categories: Cancer diseases, Genetic diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Benign Mesothelioma

MalaCards integrated aliases for Benign Mesothelioma:

Name: Benign Mesothelioma 12 15
Mesothelioma 45 17 74
Benign Tumor of Mesothelium 12
Adenomatoid Tumor 74

Classifications:



External Ids:

Disease Ontology 12 DOID:2645
MeSH 45 D008654
NCIt 51 C3234
SNOMED-CT 69 62064005
ICD10 34 C45 C45.9

Summaries for Benign Mesothelioma

Disease Ontology : 12 A cell type benign neoplasm that has material basis in mesothelium.

MalaCards based summary : Benign Mesothelioma, also known as mesothelioma, is related to mesothelioma, malignant and malignant epithelial mesothelioma, and has symptoms including snoring and coughing. An important gene associated with Benign Mesothelioma is KRT5 (Keratin 5), and among its related pathways/superpathways is Cytoskeleton remodeling Neurofilaments. The drug Alimta has been mentioned in the context of this disorder. Affiliated tissues include lung, testis and t cells, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Benign Mesothelioma

Diseases in the Benign Mesothelioma family:

Mesothelioma, Malignant Benign Intermediate Mesothelioma

Diseases related to Benign Mesothelioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 355)
# Related Disease Score Top Affiliating Genes
1 mesothelioma, malignant 33.8 KRT7 WT1
2 malignant epithelial mesothelioma 33.6 PTGER4 WT1
3 pericardial mesothelioma 33.5 KRT7 PTGER4
4 malignant biphasic mesothelioma 33.2 KRT5 KRT7 WT1
5 pleural cancer 30.1 KRT5 WT1
6 ovarian cancer 1 29.9 KRT7 WT1
7 adenomatoid tumor 29.8 KRT7 WT1
8 spindle cell carcinoma 29.7 KRT5 KRT7
9 endosalpingiosis 29.4 KRT7 PTGER4 WT1
10 peritoneal mesothelioma 12.7
11 malignant pleural mesothelioma 12.5
12 malignant peritoneal mesothelioma 12.4
13 benign multicystic peritoneal mesothelioma 12.4
14 peritoneal cystic mesothelioma 12.4
15 benign pleural mesothelioma 12.3
16 benign peritoneal mesothelioma 12.3
17 sarcomatoid mesothelioma 12.3
18 benign fibrous mesothelioma 12.2
19 lymphohistiocytoid mesothelioma 12.2
20 benign intermediate mesothelioma 12.2
21 ovarian malignant mesothelioma 12.0
22 asbestosis 11.5
23 pleural disease 11.4
24 tumor predisposition syndrome 11.2
25 bap1 tumor predisposition syndrome 11.1
26 uterine corpus adenomatoid tumor 11.0
27 epididymis adenomatoid tumor 11.0
28 lung cancer 10.7
29 adenocarcinoma 10.7
30 lung cancer susceptibility 3 10.3
31 leukemia 10.3
32 sarcoma 10.3
33 pericarditis 10.3
34 ovarian cancer 10.2
35 small cell cancer of the lung 10.2
36 constrictive pericarditis 10.2
37 lymphoma 10.2
38 wilms tumor 5 10.2
39 wilms tumor 6 10.2
40 pneumothorax 10.2
41 peritoneal serous papillary adenocarcinoma 10.2 PTGER4 WT1
42 sarcoma, synovial 10.2
43 squamous cell carcinoma 10.2
44 peritoneal serous adenocarcinoma 10.2 PTGER4 WT1
45 cardiac tamponade 10.1
46 thrombocytosis 10.1
47 inverted transitional papilloma 10.1 KRT5 KRT7
48 papilloma 10.1 KRT5 KRT7
49 balloon cell malignant melanoma 10.1 KRT5 KRT7
50 benign breast adenomyoepithelioma 10.1 KRT5 KRT7

Graphical network of the top 20 diseases related to Benign Mesothelioma:



Diseases related to Benign Mesothelioma

Symptoms & Phenotypes for Benign Mesothelioma

UMLS symptoms related to Benign Mesothelioma:


snoring, coughing

GenomeRNAi Phenotypes related to Benign Mesothelioma according to GeneCards Suite gene sharing:

27 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-1 9.53 PECAM1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-14 9.53 PECAM1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.53 KRT5
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.53 KRT5
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.53 KRT5 PECAM1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.53 KRT5
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-211 9.53 PECAM1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.53 KRT7
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.53 KRT5 KRT7
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.53 KRT7
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.53 PECAM1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.53 KRT5 KRT7 PECAM1

MGI Mouse Phenotypes related to Benign Mesothelioma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.35 DDX3X KRT7 PECAM1 PTGER4 WT1
2 muscle MP:0005369 8.92 DDX3X PECAM1 PTGER4 WT1

Drugs & Therapeutics for Benign Mesothelioma

FDA approved drugs:

# Drug Name Active Ingredient(s) 19 Company Approval Date
1
Alimta 19 50 PEMETREXED (also Pemetrexed Disodium) Eli Lilly February 2004

Search Clinical Trials , NIH Clinical Center for Benign Mesothelioma

Cochrane evidence based reviews: mesothelioma

Genetic Tests for Benign Mesothelioma

Anatomical Context for Benign Mesothelioma

MalaCards organs/tissues related to Benign Mesothelioma:

42
Lung, Testis, T Cells, Liver, Testes, Breast, Neutrophil

Publications for Benign Mesothelioma

Articles related to Benign Mesothelioma:

(show top 50) (show all 1846)
# Title Authors Year
1
Localized malignant pleural mesothelioma arising in the interlobar fissure: a unique surgical case masquerading clinicopathologically as primary lung adenocarcinoma. ( 30719319 )
2019
2
Simultaneous presence of lung adenocarcinoma and malignant pleural mesothelioma: A case report. ( 30533375 )
2019
3
Benign Multicystic Peritoneal Mesothelioma (BMPM) as a rare cause of abdominal pain in a young male: case report and review of the literature. ( 30891172 )
2019
4
Pericardial Mesothelioma in a 35-Year-Old Male With Ulcerative Colitis. ( 30632392 )
2019
5
Case Report of Aggressive Primary Pericardial Mesothelioma Presenting as a Constrictive Pericarditis. ( 30841705 )
2019
6
18F-FDG PET/CT Revealing Constrictive Pericarditis as the Only Manifestation of Malignant Mesothelioma. ( 30371590 )
2019
7
Primary pericardial mesothelioma presenting as constrictive pericarditis. ( 30624613 )
2019
8
Malignant Peritoneal Mesothelioma Mimicking Recurrent Diverticulitis. ( 30915265 )
2019
9
Mortality for Mesothelioma and Lung Cancer in a Cohort of Asbestos Cement Workers in BARI (Italy): Time Related Aspects of Exposure. ( 30870398 )
2019
10
Splicing modulation as novel therapeutic strategy against diffuse malignant peritoneal mesothelioma. ( 30581150 )
2019
11
Splicing molecular biology and novel therapies in diffuse malignant peritoneal mesothelioma. ( 30612942 )
2019
12
Pretreatment Controlling Nutritional Status Score and Lactate Dehydrogenase as Predictive Markers of Survival in Patients with Malignant Peritoneal Mesothelioma. ( 30663400 )
2019
13
Malignant Peritoneal Mesothelioma: Treatment Options and Survival. ( 30711965 )
2019
14
BAP1 haploinsufficiency predicts a distinct immunogenic class of malignant peritoneal mesothelioma. ( 30777124 )
2019
15
Malignant Peritoneal Mesothelioma Without Asbestos Exposure. ( 30834036 )
2019
16
Significance of EGFR and PTEN Expression and PLR and NLR for Predicting the Prognosis of Epithelioid Malignant Peritoneal Mesothelioma. ( 30863440 )
2019
17
Prognostic Factors of Malignant Peritoneal Mesothelioma Experienced in Japanese Peritoneal Metastasis Center. ( 30914572 )
2019
18
Treatment of malignant pleural mesothelioma with chemotherapy preceding versus after surgical resection. ( 30454981 )
2019
19
A Novel Prospective Study Assessing the Combination of Photodynamic Therapy and Proton Radiation Therapy: Safety and Outcomes When Treating Malignant Pleural Mesothelioma. ( 30485442 )
2019
20
Detection of circulating tumor cells with a novel microfluidic system in malignant pleural mesothelioma. ( 30499156 )
2019
21
Whole-Body MRI: Comparison of Its Capability for TNM Staging of Malignant Pleural Mesothelioma With That of Coregistered PET/MRI, Integrated FDG PET/CT, and Conventional Imaging. ( 30512992 )
2019
22
The FAK inhibitor BI 853520 inhibits spheroid formation and orthotopic tumor growth in malignant pleural mesothelioma. ( 30539198 )
2019
23
Pleural thickness after neoadjuvant chemotherapy is a prognostic factor in malignant pleural mesothelioma. ( 30557956 )
2019
24
Correlation of patient survival with clinical tumor measurements in malignant pleural mesothelioma. ( 30617480 )
2019
25
Return to work after surgical treatment for malignant pleural mesothelioma: report of a case. ( 30637565 )
2019
26
Surgical Risk and Survival Associated With Less Invasive Surgery for Malignant Pleural Mesothelioma. ( 30639549 )
2019
27
Usefulness of new flex-rigid pleuroscopy in the diagnosis of malignant pleural mesothelioma. ( 30642855 )
2019
28
Prognostic Factors of Survival in Patients with Malignant Pleural Mesothelioma; an analysis of the National Cancer Data Base. ( 30649229 )
2019
29
ADAM10 mediates malignant pleural mesothelioma invasiveness. ( 30651596 )
2019
30
Dosimetric Correlates of Pulmonary Toxicity in Patients with Malignant Pleural Mesothelioma Receiving Radiation Therapy to the Intact Lungs. ( 30654090 )
2019
31
Antagonists of growth hormone-releasing hormone (GHRH) inhibit the growth of human malignant pleural mesothelioma. ( 30659154 )
2019
32
Ipilimumab and nivolumab in the treatment of recurrent malignant pleural mesothelioma (INITIATE): results of a prospective, single-arm, phase 2 trial. ( 30660511 )
2019
33
Nivolumab or nivolumab plus ipilimumab in patients with relapsed malignant pleural mesothelioma (IFCT-1501 MAPS2): a multicentre, open-label, randomised, non-comparative, phase 2 trial. ( 30660609 )
2019
34
Early specialist palliative care on quality of life for malignant pleural mesothelioma: a randomised controlled trial. ( 30661019 )
2019
35
Managing malignant pleural mesothelioma: experience and perceptions of health care professionals caring for people with mesothelioma. ( 30684047 )
2019
36
MesoTRAP: a feasibility study that includes a pilot clinical trial comparing video-assisted thoracoscopic partial pleurectomy decortication with indwelling pleural catheter in patients with trapped lung due to malignant pleural mesothelioma designed to address recruitment and randomisation uncertainties and sample size requirements for a phase III trial. ( 30687504 )
2019
37
Computed tomography features of local pleural recurrence in patients with malignant pleural mesothelioma treated with intensity-modulated pleural radiation therapy. ( 30689034 )
2019
38
Gene expression profiling of homologous recombination repair pathway indicates susceptibility for olaparib treatment in malignant pleural mesothelioma in vitro. ( 30700254 )
2019
39
MST1/Hippo promoter gene methylation predicts poor survival in patients with malignant pleural mesothelioma in the IFCT-GFPC-0701 MAPS Phase 3 trial. ( 30739911 )
2019
40
Localized malignant pleural mesothelioma mimicking an anterior mediastinal tumor. ( 30740474 )
2019
41
Pemetrexed-loaded nanoparticles targeted to malignant pleural mesothelioma cells: an in vitro study. ( 30774332 )
2019
42
Physical function and health-related quality of life in the convalescent phase in surgically treated patients with malignant pleural mesothelioma. ( 30788627 )
2019
43
Malignant Pleural Mesothelioma: Is Tailoring the Second-Line Therapy Really "Raising the Bar?" ( 30790063 )
2019
44
About the diagnostic value of BAP-1 antibody in malignant pleural mesothelioma: a meta-analysis. ( 30810450 )
2019
45
Dynamic contrast-enhanced MRI of malignant pleural mesothelioma: a comparative study of pharmacokinetic models and correlation with mRECIST criteria. ( 30813957 )
2019
46
Development and Validation of a Prognostic Signature for Malignant Pleural Mesothelioma. ( 30828567 )
2019
47
Tumour infiltrating lymphocytes and PD-L1 expression as potential predictors of outcome in patients with malignant pleural mesothelioma. ( 30840203 )
2019
48
Malignant pleural mesothelioma: Is reconstruction of the diaphragm necessary in left pleurectomy/decortication? A case report. ( 30847193 )
2019
49
Prolonged post-recurrence survival following pleurectomy/decortication for malignant pleural mesothelioma. ( 30867804 )
2019
50
Cryobiopsy during flex-rigid pleuroscopy: an emerging alternative biopsy method in malignant pleural mesothelioma. A comparative study of pathology. ( 30882147 )
2019

Variations for Benign Mesothelioma

Expression for Benign Mesothelioma

Search GEO for disease gene expression data for Benign Mesothelioma.

Pathways for Benign Mesothelioma

Pathways related to Benign Mesothelioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.66 KRT5 KRT7

GO Terms for Benign Mesothelioma

Cellular components related to Benign Mesothelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratin filament GO:0045095 8.62 KRT5 KRT7

Biological processes related to Benign Mesothelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell growth GO:0030308 8.96 DDX3X WT1
2 cornification GO:0070268 8.62 KRT5 KRT7

Sources for Benign Mesothelioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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