MCID: BNG032
MIFTS: 43

Benign Mesothelioma

Categories: Cancer diseases, Genetic diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Benign Mesothelioma

MalaCards integrated aliases for Benign Mesothelioma:

Name: Benign Mesothelioma 12 15
Mesothelioma 45 17 74
Benign Tumor of Mesothelium 12
Adenomatoid Tumor 74

Classifications:



External Ids:

Disease Ontology 12 DOID:2645
MeSH 45 D008654
NCIt 51 C3234
SNOMED-CT 69 62064005
ICD10 34 C45 C45.9

Summaries for Benign Mesothelioma

Disease Ontology : 12 A cell type benign neoplasm that has material basis in mesothelium.

MalaCards based summary : Benign Mesothelioma, also known as mesothelioma, is related to mesothelioma, malignant and pericardial mesothelioma, and has symptoms including snoring and coughing. An important gene associated with Benign Mesothelioma is KRT5 (Keratin 5), and among its related pathways/superpathways is Cytoskeleton remodeling Neurofilaments. The drug Alimta has been mentioned in the context of this disorder. Affiliated tissues include lung, breast and t cells, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Benign Mesothelioma

Diseases in the Benign Mesothelioma family:

Mesothelioma, Malignant Benign Intermediate Mesothelioma

Diseases related to Benign Mesothelioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 373)
# Related Disease Score Top Affiliating Genes
1 mesothelioma, malignant 33.8 KRT7 WT1
2 pericardial mesothelioma 33.6 KRT7 PTGER4
3 malignant epithelial mesothelioma 33.6 PTGER4 WT1
4 malignant biphasic mesothelioma 33.2 KRT5 KRT7 WT1
5 spindle cell carcinoma 30.1 KRT5 KRT7
6 pleural cancer 30.1 KRT5 WT1
7 adenomatoid tumor 30.1 KRT7 WT1
8 ovarian cancer 1 29.9 KRT7 WT1
9 endosalpingiosis 29.4 KRT7 PTGER4 WT1
10 peritoneal mesothelioma 12.7
11 malignant pleural mesothelioma 12.5
12 malignant peritoneal mesothelioma 12.4
13 benign multicystic peritoneal mesothelioma 12.4
14 peritoneal cystic mesothelioma 12.4
15 benign pleural mesothelioma 12.3
16 benign peritoneal mesothelioma 12.3
17 sarcomatoid mesothelioma 12.3
18 benign fibrous mesothelioma 12.3
19 lymphohistiocytoid mesothelioma 12.2
20 benign intermediate mesothelioma 12.2
21 ovarian malignant mesothelioma 12.0
22 tumor predisposition syndrome 11.6
23 asbestosis 11.5
24 pleural disease 11.5
25 bap1 tumor predisposition syndrome 11.1
26 uterine corpus adenomatoid tumor 11.0
27 epididymis adenomatoid tumor 11.0
28 lung cancer 10.7
29 adenocarcinoma 10.7
30 asbestos intoxication 10.4
31 lung cancer susceptibility 3 10.3
32 leukemia 10.3
33 sarcoma 10.3
34 pericarditis 10.3
35 ovarian cancer 10.3
36 small cell cancer of the lung 10.2
37 constrictive pericarditis 10.2
38 lymphoma 10.2
39 wilms tumor 5 10.2
40 wilms tumor 6 10.2
41 pneumothorax 10.2
42 sarcoma, synovial 10.2
43 squamous cell carcinoma 10.2
44 peritoneal serous papillary adenocarcinoma 10.2 PTGER4 WT1
45 peritoneal serous adenocarcinoma 10.2 PTGER4 WT1
46 cardiac tamponade 10.1
47 thrombocytosis 10.1
48 inverted transitional papilloma 10.1 KRT5 KRT7
49 papilloma 10.1 KRT5 KRT7
50 balloon cell malignant melanoma 10.1 KRT5 KRT7

Graphical network of the top 20 diseases related to Benign Mesothelioma:



Diseases related to Benign Mesothelioma

Symptoms & Phenotypes for Benign Mesothelioma

UMLS symptoms related to Benign Mesothelioma:


snoring, coughing

GenomeRNAi Phenotypes related to Benign Mesothelioma according to GeneCards Suite gene sharing:

27 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-1 9.53 PECAM1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-14 9.53 PECAM1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.53 KRT5
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.53 KRT5
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.53 KRT5 PECAM1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.53 KRT5
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-211 9.53 PECAM1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.53 KRT7
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.53 KRT5 KRT7
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.53 KRT7
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.53 PECAM1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.53 KRT5 KRT7 PECAM1

MGI Mouse Phenotypes related to Benign Mesothelioma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.35 DDX3X KRT7 PECAM1 PTGER4 WT1
2 muscle MP:0005369 8.92 DDX3X PECAM1 PTGER4 WT1

Drugs & Therapeutics for Benign Mesothelioma

FDA approved drugs:

# Drug Name Active Ingredient(s) 19 Company Approval Date
1
Alimta 19 50 PEMETREXED (also Pemetrexed Disodium) Eli Lilly February 2004

Search Clinical Trials , NIH Clinical Center for Benign Mesothelioma

Cochrane evidence based reviews: mesothelioma

Genetic Tests for Benign Mesothelioma

Anatomical Context for Benign Mesothelioma

MalaCards organs/tissues related to Benign Mesothelioma:

42
Lung, Breast, T Cells, Testis, Prostate, Heart, Myeloid

Publications for Benign Mesothelioma

Articles related to Benign Mesothelioma:

(show top 50) (show all 3010)
# Title Authors Year
1
Localized malignant pleural mesothelioma arising in the interlobar fissure: a unique surgical case masquerading clinicopathologically as primary lung adenocarcinoma. ( 30719319 )
2019
2
Simultaneous presence of lung adenocarcinoma and malignant pleural mesothelioma: A case report. ( 30533375 )
2019
3
Mucin 21 is a novel, negative immunohistochemical marker for epithelioid mesothelioma for its differentiation from lung adenocarcinoma. ( 30329165 )
2019
4
Synchronous occurrence of benign mesothelioma and adenomatoid tumor of uterus: A case report and review of literature. ( 31096539 )
2019
5
Benign Multicystic Peritoneal Mesothelioma (BMPM) as a rare cause of abdominal pain in a young male: case report and review of the literature. ( 30891172 )
2019
6
Pericardial Mesothelioma in a 35-Year-Old Male With Ulcerative Colitis. ( 30632392 )
2019
7
Case Report of Aggressive Primary Pericardial Mesothelioma Presenting as a Constrictive Pericarditis. ( 30841705 )
2019
8
18F-FDG PET/CT Revealing Constrictive Pericarditis as the Only Manifestation of Malignant Mesothelioma. ( 30371590 )
2019
9
Primary pericardial mesothelioma presenting as constrictive pericarditis. ( 30624613 )
2019
10
Malignant Peritoneal Mesothelioma Mimicking Recurrent Diverticulitis. ( 30915265 )
2019
11
Thoracic Hyper-IgG4-Related Disease Mimicking Malignant Pleural Mesothelioma. ( 30941506 )
2019
12
Role of Immunotherapy in Small Cell Lung Cancer, Thymic Epithelial Tumors, and Mesothelioma. ( 31099677 )
2019
13
Mortality for Mesothelioma and Lung Cancer in a Cohort of Asbestos Cement Workers in BARI (Italy): Time Related Aspects of Exposure. ( 30870398 )
2019
14
A Rare Case of Malignant Mesothelioma Presenting with Systemic Lupus Erythematosus Seropositivity: A Case Report and Review of Literature. ( 31032152 )
2019
15
Malignant mesothelioma in Lynch syndrome: A report of two cases and a review of the literature. ( 31033031 )
2019
16
Splicing molecular biology and novel therapies in diffuse malignant peritoneal mesothelioma. ( 30612942 )
2019
17
Pretreatment Controlling Nutritional Status Score and Lactate Dehydrogenase as Predictive Markers of Survival in Patients with Malignant Peritoneal Mesothelioma. ( 30663400 )
2019
18
Malignant Peritoneal Mesothelioma: Treatment Options and Survival. ( 30711965 )
2019
19
BAP1 haploinsufficiency predicts a distinct immunogenic class of malignant peritoneal mesothelioma. ( 30777124 )
2019
20
Malignant Peritoneal Mesothelioma Without Asbestos Exposure. ( 30834036 )
2019
21
Significance of EGFR and PTEN Expression and PLR and NLR for Predicting the Prognosis of Epithelioid Malignant Peritoneal Mesothelioma. ( 30863440 )
2019
22
Prognostic Factors of Malignant Peritoneal Mesothelioma Experienced in Japanese Peritoneal Metastasis Center. ( 30914572 )
2019
23
Bilateral diffuse pulmonary infiltrates secondary to malignant peritoneal mesothelioma - A rare clinical presentation. ( 30937282 )
2019
24
The Value of COX-2, NF-κB, and Blood Routine Indexes in the Prognosis of Malignant Peritoneal Mesothelioma. ( 31063993 )
2019
25
The timing of chemotherapy in the management plan for medically operable early-stage malignant pleural mesothelioma. ( 30977408 )
2019
26
Chemotherapy Versus Supportive Care for Unresected Malignant Pleural Mesothelioma. ( 30992187 )
2019
27
Disparities in Compliance with National Guidelines for the Treatment of Malignant Pleural Mesothelioma. ( 31004585 )
2019
28
Management of Malignant Pleural Mesothelioma in the Elderly Population. ( 31011908 )
2019
29
Pathological evaluation of the visceral pleura in the radical pleurectomy/decortication for malignant pleural mesothelioma patients. ( 31019759 )
2019
30
Physician requests by patients with malignant pleural mesothelioma in Japan. ( 31023248 )
2019
31
The Correlation of Serum Mesothelin Level With Pleural Thickness in Malignant Pleural Mesothelioma Makes it a Valuable Tool for Monitoring Tumor Progression. ( 31027749 )
2019
32
Commentary: Adjuvant intensity-modulated radiation therapy for malignant pleural mesothelioma: Suspension of intention. ( 31030959 )
2019
33
First-ever Abscopal Effect after Palliative Radiotherapy and Immuno-gene Therapy for Malignant Pleural Mesothelioma. ( 31057996 )
2019
34
A phase Ib study of GSK3052230, an FGF ligand trap in combination with pemetrexed and cisplatin in patients with malignant pleural mesothelioma. ( 31065954 )
2019
35
Confocal laser endomicroscopy (CLE) as a guidance tool for pleural biopsies in malignant pleural mesothelioma. ( 31075217 )
2019
36
Potential diagnostic and prognostic role of micro-environment in malignant pleural mesothelioma. ( 31078776 )
2019
37
Loco-regional staging of malignant pleural mesothelioma by integrated 18F-FDG PET/MRI. ( 31084758 )
2019
38
Lymphangitic carcinomatosis: A common radiographic manifestation of local failure following extended pleurectomy/decortication in patients with malignant pleural mesothelioma. ( 31097101 )
2019
39
Nintedanib in combination with pemetrexed and cisplatin for chemotherapy-naive patients with advanced malignant pleural mesothelioma (LUME-Meso): a double-blind, randomised, placebo-controlled phase 3 trial. ( 31103412 )
2019
40
Moderately Hypofractionated Helical IMRT, FDG-PET/CT-guided, for Progressive Malignant Pleural Mesothelioma in Patients With Intact Lungs. ( 30253920 )
2019
41
Quantitative mass spectrometry to identify protein markers for diagnosis of malignant pleural mesothelioma. ( 30300743 )
2019
42
Immunohistochemical evaluation of nuclear 5-hydroxymethylcytosine (5-hmC) accurately distinguishes malignant pleural mesothelioma from benign mesothelial proliferations. ( 30315275 )
2019
43
Clinical significance of serum DRAM1 mRNA, ARSA mRNA, hsa-miR-2053 and lncRNA-RP1-86D1.3 axis expression in malignant pleural mesothelioma. ( 30362153 )
2019
44
Experimental study of the inhibition effect of CXCL12/CXCR4 in malignant pleural mesothelioma. ( 30367010 )
2019
45
Malignant pleural mesothelioma in Finland: regional and gender variation. ( 30375909 )
2019
46
Peripheral Blood DNA Methylation as Potential Biomarker of Malignant Pleural Mesothelioma in Asbestos-Exposed Subjects. ( 30408567 )
2019
47
Treatment of malignant pleural mesothelioma with chemotherapy preceding versus after surgical resection. ( 30454981 )
2019
48
Detection of circulating tumor cells with a novel microfluidic system in malignant pleural mesothelioma. ( 30499156 )
2019
49
Whole-Body MRI: Comparison of Its Capability for TNM Staging of Malignant Pleural Mesothelioma With That of Coregistered PET/MRI, Integrated FDG PET/CT, and Conventional Imaging. ( 30512992 )
2019
50
The FAK inhibitor BI 853520 inhibits spheroid formation and orthotopic tumor growth in malignant pleural mesothelioma. ( 30539198 )
2019

Variations for Benign Mesothelioma

Expression for Benign Mesothelioma

Search GEO for disease gene expression data for Benign Mesothelioma.

Pathways for Benign Mesothelioma

Pathways related to Benign Mesothelioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.66 KRT5 KRT7

GO Terms for Benign Mesothelioma

Cellular components related to Benign Mesothelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratin filament GO:0045095 8.62 KRT5 KRT7

Biological processes related to Benign Mesothelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell growth GO:0030308 8.96 DDX3X WT1
2 cornification GO:0070268 8.62 KRT5 KRT7

Sources for Benign Mesothelioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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