MCID: BNG032
MIFTS: 47

Benign Mesothelioma

Categories: Cancer diseases, Genetic diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Benign Mesothelioma

MalaCards integrated aliases for Benign Mesothelioma:

Name: Benign Mesothelioma 12 15
Mesothelioma 44 73
Benign Tumor of Mesothelium 12
Adenomatoid Tumor 73

Classifications:



External Ids:

Disease Ontology 12 DOID:2645
ICD10 33 C45 C45.9
MeSH 44 D008654
NCIt 50 C3234
SNOMED-CT 68 62064005

Summaries for Benign Mesothelioma

Disease Ontology : 12 A cell type benign neoplasm that has_material_basis in mesothelium.

MalaCards based summary : Benign Mesothelioma, also known as mesothelioma, is related to mesothelioma, malignant and malignant epithelial mesothelioma, and has symptoms including snoring and coughing. An important gene associated with Benign Mesothelioma is KRT5 (Keratin 5), and among its related pathways/superpathways is Cytoskeleton remodeling Neurofilaments. The drug Alimta has been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and skin.

Related Diseases for Benign Mesothelioma

Diseases in the Benign Mesothelioma family:

Mesothelioma, Malignant Benign Intermediate Mesothelioma

Diseases related to Benign Mesothelioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 318)
# Related Disease Score Top Affiliating Genes
1 mesothelioma, malignant 33.9 KRT7 WT1
2 malignant epithelial mesothelioma 33.5 PTGER4 WT1
3 malignant biphasic mesothelioma 33.2 KRT5 KRT7 WT1
4 pericardial mesothelioma 33.2 HBA1 KRT7 PTGER4
5 pleural cancer 30.0 KRT5 WT1
6 ovarian cancer 1 29.9 KRT7 WT1
7 adenomatoid tumor 29.8 KRT7 WT1
8 endosalpingiosis 29.5 KRT7 PTGER4 WT1
9 adenoid squamous cell carcinoma 29.4 HBA1 KRT7
10 peritoneal mesothelioma 12.6
11 malignant pleural mesothelioma 12.5
12 malignant peritoneal mesothelioma 12.4
13 benign multicystic peritoneal mesothelioma 12.4
14 peritoneal cystic mesothelioma 12.3
15 benign pleural mesothelioma 12.3
16 benign peritoneal mesothelioma 12.3
17 sarcomatoid mesothelioma 12.2
18 benign fibrous mesothelioma 12.2
19 lymphohistiocytoid mesothelioma 12.2
20 benign intermediate mesothelioma 12.1
21 ovarian malignant mesothelioma 12.0
22 asbestosis 11.5
23 pleural disease 11.4
24 tumor predisposition syndrome 11.2
25 bap1 tumor predisposition syndrome 11.1
26 uterine corpus adenomatoid tumor 11.0
27 epididymis adenomatoid tumor 11.0
28 lung cancer 10.6
29 adenocarcinoma 10.6
30 lung cancer susceptibility 3 10.3
31 pericarditis 10.3
32 sarcoma 10.2
33 ovarian cancer 10.2
34 constrictive pericarditis 10.2
35 lymphoma 10.2
36 wilms tumor 6 10.1
37 squamous cell carcinoma 10.1
38 small cell cancer of the lung 10.1
39 cardiac tamponade 10.1
40 thrombocytosis 10.1
41 peritoneal serous papillary adenocarcinoma 10.1 PTGER4 WT1
42 peritoneal serous adenocarcinoma 10.1 PTGER4 WT1
43 sarcoma, synovial 10.1
44 inverted transitional papilloma 10.1 KRT5 KRT7
45 papilloma 10.1 KRT5 KRT7
46 balloon cell malignant melanoma 10.1 KRT5 KRT7
47 benign breast adenomyoepithelioma 10.1 KRT5 KRT7
48 breast adenomyoepithelioma 10.1 KRT5 KRT7
49 ceruminoma 10.1 KRT5 KRT7
50 malignant spiradenoma 10.1 KRT5 KRT7

Graphical network of the top 20 diseases related to Benign Mesothelioma:



Diseases related to Benign Mesothelioma

Symptoms & Phenotypes for Benign Mesothelioma

UMLS symptoms related to Benign Mesothelioma:


snoring, coughing

Drugs & Therapeutics for Benign Mesothelioma

FDA approved drugs:

# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Alimta 18 49 PEMETREXED (also Pemetrexed Disodium) Eli Lilly February 2004

Search Clinical Trials , NIH Clinical Center for Benign Mesothelioma

Cochrane evidence based reviews: mesothelioma

Genetic Tests for Benign Mesothelioma

Anatomical Context for Benign Mesothelioma

MalaCards organs/tissues related to Benign Mesothelioma:

41
Lung, T Cells, Skin, Endothelial, Ovary, Testes, Testis

Publications for Benign Mesothelioma

Articles related to Benign Mesothelioma:

(show top 50) (show all 822)
# Title Authors Year
1
Simultaneous presence of lung adenocarcinoma and malignant pleural mesothelioma: A case report. ( 30533375 )
2019
2
Well-differentiated papillary mesothelioma of the tunica vaginalis: Case report and literature review. ( 30306051 )
2019
3
The significance of non-occupational asbestos exposure in women with mesothelioma. ( 30479770 )
2019
4
Virotherapy-recruited PMN-MDSC infiltration of mesothelioma blocks antitumor CTL by IL-10-mediated dendritic cell suppression. ( 30546960 )
2019
5
Pyruvate Treatment Restores the Effectiveness of Chemotherapeutic Agents in Human Colon Adenocarcinoma and Pleural Mesothelioma Cells. ( 30423827 )
2018
6
MUC21 is a novel, negative immunohistochemical marker for epithelioid mesothelioma for its differentiation from lung adenocarcinoma. ( 30329165 )
2018
7
Concurrent thoracic mesothelioma and thyroid C-cell adenoma with amyloid deposition in an aged horse. ( 29468082 )
2018
8
Occupational Burden of Asbestos-Related Diseases in Korea, 1998-2013: Asbestosis, Mesothelioma, Lung Cancer, Laryngeal Cancer, and Ovarian Cancer. ( 30140191 )
2018
9
Benign Multicystic Peritoneal Mesothelioma in a Male Patient with Previous Wilms' Tumor: A Case Report and Review of the Literature. ( 30155337 )
2018
10
An unusual cause of acute surgical abdomen: benign multicystic peritoneal mesothelioma associated with adenomatous tumor. ( 30534842 )
2018
11
Malignant Pleural Mesothelioma presenting with Cardiac Tamponade- A Rare Case report and Review of the literature. ( 30294454 )
2018
12
Pericardial mesothelioma presenting as chronic constrictive pericarditis. A series of three cases from a single institution. ( 30303153 )
2018
13
18F-FDG PET/CT Revealing Constrictive Pericarditis as the Only Manifestation of Malignant Mesothelioma. ( 30371590 )
2018
14
Tumor Symbiosis: Gastrointestinal Stromal Tumor as a Host for Primary Peritoneal Mesothelioma. ( 30132292 )
2018
15
Hypoxia promotes acquisition of aggressive phenotypes in human malignant mesothelioma. ( 30111297 )
2018
16
Satisfactory results of a psychometric analysis and calculation of minimal clinically important differences of the World Health Organization quality of life-BREF questionnaire in an observational cohort study with lung cancer and mesothelioma patients. ( 30477456 )
2018
17
Safety of Same-Day Vitamin B12 Supplementation in Patients Receiving Pemetrexed for the Treatment of Non-Small-Cell Lung Cancer or Pleural Mesothelioma: A Retrospective Analysis. ( 30369425 )
2018
18
Elevated Serum Megakaryocyte Potentiating Factor as a Predictor of Poor Survival in Patients with Mesothelioma and Primary Lung Cancer. ( 30370398 )
2018
19
Mesothelioma and other lung disease in taconite miners; the uncertain role of non-asbestiform EMP. ( 29653125 )
2018
20
IMP3 as a prognostic biomarker in patients with malignant peritoneal mesothelioma. ( 30031101 )
2018
21
First case report of malignant peritoneal mesothelioma and oral verrucous carcinoma in a patient with a germline PTEN mutation: a combination of extremely rare diseases with probable further implications. ( 30111295 )
2018
22
Malignant Peritoneal Mesothelioma in an Infant With Familial ATM Mutations. ( 30124550 )
2018
23
Malignant Peritoneal Mesothelioma: A Rare Cause of Ascites. ( 30349836 )
2018
24
Malignant peritoneal mesothelioma: clinical aspects, and therapeutic perspectives. ( 30386115 )
2018
25
ASO Author Reflections: Management of Malignant Peritoneal Mesothelioma. ( 30421065 )
2018
26
Malignant peritoneal mesothelioma: a review. ( 30450291 )
2018
27
Update on the management of malignant peritoneal mesothelioma. ( 30450299 )
2018
28
Complex Immune Contextures Characterise Malignant Peritoneal Mesothelioma: Loss of Adaptive Immunological Signature in the More Aggressive Histological Types. ( 30510965 )
2018
29
A single centre phase II trial to assess the immunological activity of TroVax® plus pemetrexed/cisplatin in patients with malignant pleural mesothelioma - the SKOPOS trial. ( 30524880 )
2018
30
Low-dose cyclophosphamide depletes circulating naïve and activated regulatory T cells in malignant pleural mesothelioma patients synergistically treated with dendritic cell-based immunotherapy. ( 30524884 )
2018
31
Clustering of malignant pleural mesothelioma in asbestos factories: a subgroup analysis in a 29-year follow-up study to identify high-risk industries in Taiwan. ( 30530573 )
2018
32
Combined modality treatment for malignant pleural mesothelioma: a single-centre long-term survival analysis using extrapleural pneumonectomy. ( 30535191 )
2018
33
The FAK inhibitor BI 853520 inhibits spheroid formation and orthotopic tumor growth in malignant pleural mesothelioma. ( 30539198 )
2018
34
BAP1 gene mutations in Egyptian patients with advanced sporadic malignant pleural mesothelioma (MPM): relation with clinical outcomes and survival. ( 30553477 )
2018
35
Updates in the diagnosis and treatment of malignant pleural mesothelioma. ( 29553973 )
2018
36
Inhibition of yes-associated protein down-regulates PD-L1 (CD274) expression in human malignant pleural mesothelioma. ( 29575535 )
2018
37
National Cancer Database Report on Pneumonectomy Versus Lung-Sparing Surgery for Malignant Pleural Mesothelioma. ( 29576300 )
2018
38
Quality of life of survivors of malignant pleural mesothelioma in Japan: a cross sectional study. ( 29587685 )
2018
39
SYSTEMS-2: A randomised phase II study of radiotherapy dose escalation for pain control in malignant pleural mesothelioma. ( 29594241 )
2018
40
Heterogeneity in Immune Cell Content in Malignant Pleural Mesothelioma. ( 29601534 )
2018
41
Malignant pleural mesothelioma-the impact of globalization on rare diseases. ( 29607128 )
2018
42
Malignant Pleural Mesothelioma with Bone Marrow Metastases. ( 29607973 )
2018
43
Malignant Pleural Mesothelioma: Are There Imaging Characteristics Associated With Different Histologic Subtypes on Computed Tomography? ( 29613986 )
2018
44
Malignant pleural mesothelioma: diagnostic value of medical thoracoscopy and long-term prognostic analysis. ( 29615010 )
2018
45
Poor Prognostic Factors in Patients with Malignant Pleural Mesothelioma Classified as Pathological Stage IB According to the Eighth Edition TNM Classification. ( 29616420 )
2018
46
Comprehensive immunoproteogenomic analyses of malignant pleural mesothelioma. ( 29618661 )
2018
47
FGF2 and EGF induce epithelial-mesenchymal transition in malignant pleural mesothelioma cells via a MAPKinase/MMP1 signal. ( 29635378 )
2018
48
New Perspectives on Diagnosis and Therapy of Malignant Pleural Mesothelioma. ( 29666782 )
2018
49
Video-assisted thoracoscopic PlasmaJet ablation for malignant pleural mesothelioma. ( 29682466 )
2018
50
In Silico and In Vitro Analyses of LncRNAs as Potential Regulators in the Transition from the Epithelioid to Sarcomatoid Histotype of Malignant Pleural Mesothelioma (MPM). ( 29701689 )
2018

Variations for Benign Mesothelioma

Expression for Benign Mesothelioma

Search GEO for disease gene expression data for Benign Mesothelioma.

Pathways for Benign Mesothelioma

Pathways related to Benign Mesothelioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.66 KRT5 KRT7

GO Terms for Benign Mesothelioma

Cellular components related to Benign Mesothelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratin filament GO:0045095 8.96 KRT5 KRT7
2 cytosolic small ribosomal subunit GO:0022627 8.62 DDX3X HBA1

Biological processes related to Benign Mesothelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell growth GO:0030308 8.96 DDX3X WT1
2 cornification GO:0070268 8.62 KRT5 KRT7

Sources for Benign Mesothelioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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