MCID: BNG041
MIFTS: 29

Benign Metastasizing Leiomyoma

Categories: Cancer diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Benign Metastasizing Leiomyoma

MalaCards integrated aliases for Benign Metastasizing Leiomyoma:

Name: Benign Metastasizing Leiomyoma 20
Benign Metastasizing Leiomyoma of Uterus 70

Classifications:



External Ids:

UMLS 70 C0346201

Summaries for Benign Metastasizing Leiomyoma

MalaCards based summary : Benign Metastasizing Leiomyoma, also known as benign metastasizing leiomyoma of uterus, is related to intravenous leiomyomatosis and leiomyoma. An important gene associated with Benign Metastasizing Leiomyoma is DES (Desmin), and among its related pathways/superpathways are Cytoskeletal Signaling and Cytoskeleton remodeling Neurofilaments. Affiliated tissues include uterus, smooth muscle and lymph node, and related phenotypes are cellular and homeostasis/metabolism

Wikipedia : 73 Benign metastasizing leiomyoma is a rare condition characterized by the growth of uterine leiomyoma in... more...

Related Diseases for Benign Metastasizing Leiomyoma

Diseases related to Benign Metastasizing Leiomyoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 241)
# Related Disease Score Top Affiliating Genes
1 intravenous leiomyomatosis 31.3 PGR DES
2 leiomyoma 31.0 VIM PGR DES CYP19A1 ACTC1
3 lung leiomyoma 30.8 PGR MIR221
4 leiomyosarcoma 30.7 VIM PGR DES ACTC1
5 rare tumor 30.4 DES ACTC1
6 smooth muscle tumor 30.3 VIM PGR DES ACTC1
7 fibrosarcoma 30.0 VIM DES ACTC1
8 spindle cell sarcoma 29.5 VIM KRT7 DES ACTC1
9 angiomyolipoma 29.2 VIM PGR KRT7 DES ACTC1
10 leiomyoma, uterine 10.9
11 myoma 10.6
12 leiomyomatosis 10.6
13 lymphangioleiomyomatosis 10.4
14 myofibroma 10.4
15 cervical polyp 10.3 PGR DES
16 respiratory failure 10.3
17 pneumothorax 10.3
18 virus-associated trichodysplasia spinulosa 10.3
19 fibroblastic rheumatism 10.3 DES ACTC1
20 ovarian fibrothecoma 10.3 DES ACTC1
21 pulmonary vein stenosis 10.3 DES ACTC1
22 botryoid rhabdomyosarcoma 10.2 DES ACTC1
23 calcifying aponeurotic fibroma 10.2 PGR ACTC1
24 non-langerhans-cell histiocytosis 10.2 DES ACTC1
25 glycogen-rich clear cell breast carcinoma 10.2 PGR ACTC1
26 breast myoepithelial carcinoma 10.2 PGR ACTC1
27 bizarre leiomyoma 10.2 PGR ACTC1
28 myxoid leiomyosarcoma 10.2 PGR ACTC1
29 ischemic fasciitis 10.2 DES ACTC1
30 infantile digital fibromatosis 10.2 VIM DES
31 primitive neuroectodermal tumor of the cervix uteri 10.2 VIM DES
32 pneumothorax, primary spontaneous 10.2
33 pulmonary arteriovenous fistulas 10.2
34 lung cancer susceptibility 3 10.2
35 b-lymphoblastic leukemia/lymphoma 10.2
36 arteriovenous malformation 10.2
37 pleural empyema 10.2
38 ovarian cyst 10.2
39 cellular leiomyoma 10.2
40 pulmonary coin lesion 10.2
41 lung disease 10.2
42 pulmonary arteriovenous malformation 10.2
43 back pain 10.2
44 paresthesia 10.2
45 embryonal sarcoma 10.2 VIM DES
46 subserous uterine fibroid 10.2 PGR CYP19A1
47 diffuse peritoneal leiomyomatosis 10.2 PGR CYP19A1
48 endometrial mucinous adenocarcinoma 10.2 VIM PGR
49 vaginal endometrial stromal sarcoma 10.2 VIM PGR
50 lymphangiectasis 10.2 VIM ACTC1

Graphical network of the top 20 diseases related to Benign Metastasizing Leiomyoma:



Diseases related to Benign Metastasizing Leiomyoma

Symptoms & Phenotypes for Benign Metastasizing Leiomyoma

MGI Mouse Phenotypes related to Benign Metastasizing Leiomyoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.7 ACTC1 BCL2 CYP19A1 DES KRT7 PGR
2 homeostasis/metabolism MP:0005376 9.56 ACTC1 BCL2 CYP19A1 DES KRT7 LGALS1
3 muscle MP:0005369 9.17 ACTC1 BCL2 CYP19A1 DES LGALS1 PGR

Drugs & Therapeutics for Benign Metastasizing Leiomyoma

Search Clinical Trials , NIH Clinical Center for Benign Metastasizing Leiomyoma

Genetic Tests for Benign Metastasizing Leiomyoma

Anatomical Context for Benign Metastasizing Leiomyoma

MalaCards organs/tissues related to Benign Metastasizing Leiomyoma:

40
Uterus, Smooth Muscle, Lymph Node, Spinal Cord, Skeletal Muscle, Small Intestine, Ovary

Publications for Benign Metastasizing Leiomyoma

Articles related to Benign Metastasizing Leiomyoma:

(show top 50) (show all 238)
# Title Authors PMID Year
1
Benign metastasizing leiomyoma in femur and thigh with a history of uterine leiomyoma: A case report and literature review. 61
33164252 2021
2
Large Isolated Benign Metastasizing Leiomyoma of the Lung. 61
33220281 2021
3
[Pulmonary Benign Metastasizing Leiomyoma Found as Multiple Bilateral Lung Nodules 11 Years after Hysterectomy;Report of a Case]. 61
33271588 2020
4
Right heart failure due to benign metastasizing leiomyoma: a case report of this exceedingly rare condition and review of the literature. 61
33442611 2020
5
Pulmonary benign metastasizing leiomyomas: a case series of 23 patients at a single facility. 61
33172427 2020
6
CT findings of pathology proven benign metastasizing leiomyoma. 61
32944110 2020
7
Co-presentation of pulmonary arteriovenous malformation (PAVM) and multifocal benign metastasizing leiomyoma (BML) of lungs: Diagnostic dilemma and successful endovascular treatment. 61
32442856 2020
8
Pulmonary benign metastasizing leiomyoma: a case report and literature review. 61
33040539 2020
9
[Clinicopathological features and gene phenotypes of benign metastasizing leiomyoma]. 61
32610382 2020
10
Pulmonary benign metastasizing leiomyoma: A case report and review of the literature. 61
32775390 2020
11
Molecular Profiling of Benign Metastasizing Leiomyoma of the Uterus Revealing Unique Novel Therapeutic Targets. 61
32431980 2020
12
Cardiac metastasizing leiomyoma: A case report. 61
33395865 2020
13
Intranodal Hemangioma in the Pelvic Cavity: A Case Report. 61
33135609 2020
14
Disseminated peritoneal leiomyomatosis: an unusual presentation of intra-abdominal lesion mimicking disseminated malignancy. 61
32133455 2020
15
An unusual cause of multiple incidental lung nodules. 61
31998524 2020
16
Pulmonary and mediastinum metastasis of uterine leiomyoma: A case report. 61
31804368 2019
17
Multiple organ benign metastasizing leiomyoma: A case report and literature review. 61
31381225 2019
18
Multiple Benign Metastasizing Leiomyoma of the uterus in lung and retroperitoneum. 61
31464228 2019
19
[Benign metastasizing leiomyoma: A case report andliterature review]. 61
31570686 2019
20
Cancer Genes Mutations in Benign Metastasizing Leiomyoma: A Case Report. 61
31523581 2019
21
Pulmonary benign metastasizing leiomyoma presenting as small, diffuse nodules. 61
31365684 2019
22
Natural history of leiomyomas beyond the uterus. 61
31232922 2019
23
Lung metastases from benign uterine leiomyoma: does 18-FDG-PET/CT have a role to play? 61
30074141 2019
24
Benign metastasizing leiomyoma presenting with miliary pattern and fatal outcome: Case report with molecular analysis & review of the literature. 61
30989050 2019
25
Multisystemic Benign Metastasizing Leiomyoma: An Unusual Condition with an Atypical Clinical Presentation. 61
31093407 2019
26
Benign Metastasizing Leiomyoma to the Lung and Spine: A Case Report and Literature Review. 61
31011319 2019
27
Case of pulmonary benign metastasizing leiomyoma from synchronous uterine leiomyoma in a postmenopausal woman. 61
30225333 2018
28
Post-menopausal pulmonary leiomyoma metastasis: an unexpected finding. 61
33060928 2018
29
Perivascular Leiomyomatosis: A Unique Case Report. 61
29692211 2018
30
Deep sequencing reveals the molecular pathology characteristics between primary uterine leiomyoma and pulmonary benign metastasizing leiomyoma. 61
29484624 2018
31
Concurrent benign metastasizing leiomyoma in the lung and lumbar spine with elevated standardized uptake value level in positron-emission tomography computed tomography: A case report and literature review. 61
29979408 2018
32
Aberrant uterine leiomyomas with extrauterine manifestation: intravenous leiomyomatosis and benign metastasizing leiomyomas. 61
30018906 2018
33
[Benign metastasizing leiomyoma: An unusual cause of aggressive femoral bone tumor]. 61
29502928 2018
34
Intravenous leiomyomatosis of the uterus: A clinicopathologic analysis of 13 cases with an emphasis on histogenesis. 61
29699902 2018
35
[Benign pulmonary metastases from a leiomyoma]. 61
29793807 2018
36
Pelvic and pulmonary benign metastasizing leiomyoma: A case report. 61
29785389 2018
37
Concurrent pulmonary benign metastasizing leiomyoma and primary lung adenocarcinoma: a case report. 61
30264014 2018
38
Pulmonary benign metastasizing leiomyoma: A case report. 61
29977777 2018
39
The Heart as a Site of Metastasis of Benign Metastasizing Leiomyoma: Case Report and Review of the Literature. 61
29951323 2018
40
Benign Metastasizing Leiomyoma of the Uterus: Rare Manifestation of a Frequent Pathology. 61
30510824 2018
41
Whole exome sequencing of benign pulmonary metastasizing leiomyoma reveals mutation in the BMP8B gene. 61
29386003 2018
42
Benign metastasizing leiomyoma presenting as multiple cystic pulmonary nodules: a case report. 61
28899426 2017
43
Benign metastasizing leiomyoma and 18-FDG-PET/CT: A case report and literature review. 61
28927125 2017
44
A rare case of benign metastasizing leiomyoma†. 61
28959432 2017
45
[The clinical characteristics of pulmonary benign metastasizing leiomyoma]. 61
28693056 2017
46
Massively parallel sequencing and genome-wide copy number analysis revealed a clonal relationship in benign metastasizing leiomyoma. 61
28533481 2017
47
Benign Metastasizing Leiomyoma. 61
27659239 2017
48
Primary intracardiac leiomyoma arising from cardiomyocyte progenitors at the right ventriculoseptal interface: case report with literature review. 61
28314213 2017
49
[Pulmonary Benign Metastasizing Leiomyoma Resected Six Times during Twenty Years;Report of a Case]. 61
28293011 2017
50
Pulmonary benign metastasizing leiomyoma presented as acute respiratory distress. 61
28116091 2017

Variations for Benign Metastasizing Leiomyoma

Expression for Benign Metastasizing Leiomyoma

Search GEO for disease gene expression data for Benign Metastasizing Leiomyoma.

Pathways for Benign Metastasizing Leiomyoma

Pathways related to Benign Metastasizing Leiomyoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.75 VIM KRT7 DES ACTC1
2
Show member pathways
11.37 VIM KRT7 DES
3
Show member pathways
10.97 VIM DES
4 10.76 PGR CYP19A1
5 10.66 VIM DES ACTC1

GO Terms for Benign Metastasizing Leiomyoma

Cellular components related to Benign Metastasizing Leiomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 8.8 VIM KRT7 DES

Biological processes related to Benign Metastasizing Leiomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.33 LGALS1 BCL2 ACTC1
2 intermediate filament organization GO:0045109 8.96 VIM DES
3 muscle filament sliding GO:0030049 8.8 VIM DES ACTC1

Molecular functions related to Benign Metastasizing Leiomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.02 VIM PGR LGALS1 DES BCL2

Sources for Benign Metastasizing Leiomyoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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