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BPPV
MCID: BNG018
MIFTS: 39

Benign Paroxysmal Positional Nystagmus (BPPV)

Categories: Ear diseases, Genetic diseases, Rare diseases
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs
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Aliases & Classifications for Benign Paroxysmal Positional Nystagmus

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MalaCards integrated aliases for Benign Paroxysmal Positional Nystagmus:

Name: Benign Paroxysmal Positional Nystagmus 12 15
Benign Paroxysmal Positional Vertigo 12 76 53 44 63 73
Familial Benign Recurrent Vertigo 53
Familial Vestibulopathy 53
Bppv 53

Classifications:

MalaCards categories:
Global: Rare diseases Genetic diseases
Anatomical: Ear diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:13941
ICD9CM 35 386.11
MeSH 44 D065635
UMLS 73 C0155502
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Summaries for Benign Paroxysmal Positional Nystagmus

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PubMed Health : 63 About benign paroxysmal positional vertigo: Vertigo can be described as a kind of dizziness that makes it feel like everything is spinning around or moving. It can occur while standing, walking or lying down. Depending on what’s causing the dizziness, the length of an episode can vary greatly, and may be accompanied by drowsiness, nausea or other symptoms.The most common cause of this type of vertigo is benign paroxysmal positional vertigo (BPPV). Here certain movements cause dizziness for a short time. BPPV is quite easy to diagnose and treat.

MalaCards based summary : Benign Paroxysmal Positional Nystagmus, also known as benign paroxysmal positional vertigo, is related to vertigo, benign recurrent and osteoporosis, and has symptoms including vertigo, vertigo/dizziness and cupulolithiasis. An important gene associated with Benign Paroxysmal Positional Nystagmus is FBXO2 (F-Box Protein 2). The drugs Calcium Carbonate and Vitamin D3 have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and brain.

Wikipedia : 76 Benign paroxysmal positional vertigo (BPPV) is a disorder arising from a problem in the inner ear.... more...

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Related Diseases for Benign Paroxysmal Positional Nystagmus

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Diseases related to Benign Paroxysmal Positional Nystagmus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 vertigo, benign recurrent 12.3
2 osteoporosis 10.6
3 sensorineural hearing loss 10.5
4 sudden sensorineural hearing loss 10.5
5 anxiety 10.4
6 bone mineral density quantitative trait locus 8 10.4
7 bone mineral density quantitative trait locus 15 10.4
8 pathologic nystagmus 10.3
9 thyroiditis 10.3
10 inner ear disease 10.2
11 meniere disease 10.1
12 migraine with or without aura 1 10.1
13 spondyloarthropathy 1 10.1
14 epidermoid cysts 10.1
15 scleroderma, familial progressive 10.1
16 spinocerebellar ataxia 6 10.1
17 temporal arteritis 10.1
18 orthostatic intolerance 10.1
19 nasopharyngeal carcinoma 10.1
20 hydrocephalus 10.1
21 spinal cord injury 10.1
22 cholesteatoma of middle ear 10.1
23 otosclerosis 10.1
24 acoustic neuroma 10.1
25 dementia 10.1
26 autosomal dominant cerebellar ataxia 10.1
27 personality disorder 10.1
28 hyperinsulinism 10.1
29 auditory system disease 10.1
30 ischemia 10.1
31 hyperglycemia 10.1
32 intracranial hypotension 10.1
33 benign ependymoma 10.1
34 spondylitis 10.1
35 congenital hydrocephalus 10.1
36 ependymoma 10.1
37 perilymphatic fistula 10.1
38 depression 10.1
39 syncope 10.1
40 spontaneous intracranial hypotension 10.1
41 deafness, autosomal recessive 4, with enlarged vestibular aqueduct 9.9
42 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.9
43 brain injury 9.9
44 traumatic brain injury 9.9
45 vestibular neuronitis 9.9
46 neuritis 9.9
47 neuronitis 9.9
48 chronic fatigue syndrome 9.9
49 pain - chronic 9.9
50 whiplash 9.9

Graphical network of the top 20 diseases related to Benign Paroxysmal Positional Nystagmus:



Diseases related to Benign Paroxysmal Positional Nystagmus
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Symptoms & Phenotypes for Benign Paroxysmal Positional Nystagmus

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UMLS symptoms related to Benign Paroxysmal Positional Nystagmus:


vertigo, vertigo/dizziness, cupulolithiasis
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Drugs & Therapeutics for Benign Paroxysmal Positional Nystagmus

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PubMedHealth treatment related to Benign Paroxysmal Positional Nystagmus: 63

“Repositioning” procedures or maneuvers are commonly used to treat BPPV. They involve moving the patient into specific lying or sitting positions following a certain sequence, with specific positions of the head. The sequence of movements is designed to help move the tiny crystals out of the posterior semicircular canal and into areas of the vestibular system where they can no longer disturb the sensory hair cells.The Epley maneuver and the Semont maneuver are two very simple and effective repositioning procedures for the treatment of BPPV caused by crystals in the posterior semicircular canal. These maneuvers are typically done several times with the help of a doctor. There are also slightly modified repositioning procedures that can be done at home in addition to the doctor-assisted maneuvers.The crystals are only rarely found in either of the other semicircular canals. Then other repositioning maneuvers can be used.Medication can help if the vertigo is causing nausea.If the symptoms persist, surgery on the vestibular system may be considered. This involves destroying either the nerve fibers that are connected to the affected semicircular canal, or the semicircular canal itself. The hair cells can then no longer transmit misleading information – or any other information – to the brain. This means that the vestibular system in that ear is permanently affected by the surgery.

Drugs for Benign Paroxysmal Positional Nystagmus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Calcium Carbonate Approved, Investigational Phase 4 471-34-1
2
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 5280795 6221
3
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
4
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
5 Calcium Supplement Phase 4
6 Anti-Ulcer Agents Phase 4
7 Calciferol Phase 4
8 Micronutrients Phase 4
9 Calcium, Dietary Phase 4
10 Ergocalciferols Phase 4
11 Gastrointestinal Agents Phase 4,Not Applicable
12 Vitamin D2 Phase 4
13 Antacids Phase 4
14 Trace Elements Phase 4
15 Vitamins Phase 4
16 Bone Density Conservation Agents Phase 4
17
Lorazepam Approved Not Applicable 846-49-1 3958
18
Promethazine Approved, Investigational Not Applicable 60-87-7 4927
19
Histamine Approved, Investigational Not Applicable 51-45-6, 75614-87-8 774
20
Diphenhydramine Approved, Investigational Not Applicable 147-24-0, 58-73-1 3100
21
Ondansetron Approved Not Applicable 99614-02-5 4595
22
Diazepam Approved, Illicit, Investigational, Vet_approved Not Applicable 439-14-5 3016
23
Meclizine Approved Not Applicable 569-65-3 4034
24
Betahistine Approved, Investigational Not Applicable 5638-76-6 2366
25
Histamine Phosphate Not Applicable 51-74-1 65513
26 Peripheral Nervous System Agents Not Applicable
27 Serotonin Agents Not Applicable
28 Psychotropic Drugs Not Applicable
29 Serotonin Antagonists Not Applicable
30 Anti-Allergic Agents Not Applicable
31 Histamine Antagonists Not Applicable
32 Hypnotics and Sedatives Not Applicable
33 Antipsychotic Agents Not Applicable
34 Anesthetics Not Applicable
35 Anesthetics, Local Not Applicable
36 Dermatologic Agents Not Applicable
37 Central Nervous System Depressants Not Applicable
38 Anticonvulsants Not Applicable
39 Autonomic Agents Not Applicable
40 Tranquilizing Agents Not Applicable
41 Antiemetics Not Applicable
42 Anti-Anxiety Agents Not Applicable
43 GABA Agents Not Applicable
44 GABA Modulators Not Applicable
45 Neurotransmitter Agents Not Applicable
46 Antipruritics Not Applicable
47 Histamine H1 Antagonists Not Applicable
48 Vasodilator Agents Not Applicable
49
Serotonin Investigational, Nutraceutical Not Applicable 50-67-9 5202

Interventional clinical trials:

(show all 33)
# Name Status NCT ID Phase Drugs
1 Efficacy of Vitamin D and Calcium Supplementation on the Prevention of Recurrences in BPPV Completed NCT02031692 Phase 4 400IU cholecalciferol and 500mg of elemental calcium as calcium carbonate
2 The Treatment of Posterior Semicircular Canal Benign Paroxysmal Positional Vertigo Completed NCT02029508 Phase 3
3 Treatment of Geotropic Horizontal Canal Benign Paroxysmal Positional Vertigo Completed NCT01366430 Phase 3
4 Treatment of Apogeotropic Horizontal Canal Benign Paroxysmal Positional Vertigo Completed NCT00810641 Phase 3
5 Canalith Repositioning Procedure for BPPV in Primary Care Completed NCT00182273 Phase 3
6 Visual Feedback Goggle for Positional Vertigo Treatment Unknown status NCT00729885 Phase 1, Phase 2
7 Treatment of Apogeotropic Horizontal Canal Benign Paroxysmal Positional Vertigo Completed NCT02046980 Phase 2
8 Treatments for Benign Paroxysmal Positional Vertigo (BPPV) Completed NCT00000359 Phase 2
9 Efficacy of Postural Restriction in Treating Benign Paroxysmal Positional Vertigo Unknown status NCT02475239 Not Applicable
10 Treatment of Posterior Canal Type of Benign Paroxysmal Positional Vertigo Unknown status NCT01822002 Not Applicable
11 The Liberatory Maneuver for the Treatment of Benign Paroxysmal Positional Vertigo (BPPV) Unknown status NCT01008124 Not Applicable
12 Comparison of Home-Based Exercise on the Posterior Canal Benign Paroxysmal Positional Vertigo Symptoms Completed NCT03230513 Not Applicable
13 Evidence Based Best Care Practice for Benign Paroxysmal Positional Vertigo Completed NCT02809599 Not Applicable
14 Treating Benign Paroxysmal Positional Vertigo (BPPV) in ED Patients Completed NCT00641797 Not Applicable Meclizine;Lorazepam;Diphenhydramine;Ondansetron
15 Vestibular Evoked Myogenic Potentials in Benign Paroxysmal Positional Vertigo (VEMP in BPPV) Completed NCT01004913
16 BPPV Treatment in Biaxial Rotational Chair Completed NCT01905800 Not Applicable
17 Clinical Aspects of Patients With Benign Paroxysmal Positional Vertigo (BPPV) and Migraine Completed NCT02615314
18 Effectiveness of the Epley Manoeuvre Performed in Primary Care to Treat Benign Paroxysmal Positional Vertigo Completed NCT01969513 Not Applicable
19 Effectiveness of Osteopathic Manipulative Treatment (OMT) and Vestibular Rehabilitation Therapy (VRT) in Individuals With Vertigo Completed NCT01529151 Not Applicable
20 To Study the Characteristics of Different Types of Vertigo in Patients Attending the Ear Nose & Throat (ENT) Clinics. Completed NCT02213120
21 Osteotome Sinus Floor Elevation With or Without Grafting Completed NCT01619956 Not Applicable
22 Sinus Lift: Saving Time and Reducing Morbidity Completed NCT02415946 Not Applicable
23 Different Treatments With the TRV Reposition Chair Recruiting NCT03541018 Not Applicable
24 BPPV With CRP: Single Versus Multiple Cycles Recruiting NCT02701218 Not Applicable
25 Inactivity, Balance Problems and Fall Risk in Institutionalized Frail Elderly Recruiting NCT02905292
26 Interventions for Residual Dizziness After Successful Repositioning Maneuvers in Patients With BPPV Recruiting NCT03624283 Not Applicable Betahistine
27 3D Model of Posterior Membranous Labyrinth of the Inner Ear Recruiting NCT03295929
28 Acute Video-oculography for Vertigo in Emergency Rooms for Rapid Triage (AVERT) Recruiting NCT02483429 Not Applicable
29 Clinical Evaluation of Two Types of Transalveolar Sinus Floor Elevation Recruiting NCT03445039 Not Applicable
30 Efficacy of a Mechanical Chair for Treatment of Benign Paroxysmal Positional Vertigo (BPPV) Enrolling by invitation NCT03161470 Not Applicable
31 Benign Paroxysmal Positional Vertigo (BPPV) Training for Sports Medicine Providers in a Pediatric Concussion Program Not yet recruiting NCT03425786 Not Applicable
32 Evaluation of the Prevalence of BPPV and Longterm Effects of Its Therapy Using the Rotundum Device in Retirement Homes Not yet recruiting NCT03643354 Not Applicable
33 Effects of Physical Treatment on Postural Stability in Benign Paroxysmal Positional Vertigo (BPPV) Patients Withdrawn NCT00978809 Not Applicable

Search NIH Clinical Center for Benign Paroxysmal Positional Nystagmus

Cochrane evidence based reviews: benign paroxysmal positional vertigo

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Genetic Tests for Benign Paroxysmal Positional Nystagmus

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Anatomical Context for Benign Paroxysmal Positional Nystagmus

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MalaCards organs/tissues related to Benign Paroxysmal Positional Nystagmus:

41
Testes, Bone, Brain, Thyroid, Spinal Cord, Cerebellum
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Publications for Benign Paroxysmal Positional Nystagmus

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Articles related to Benign Paroxysmal Positional Nystagmus:

(show top 50) (show all 834)
# Title Authors Year
1
Benign paroxysmal positional vertigo in children. ( 30220115 )
2019
2
Reduction of bone mineral density in native Chinese female idiopathic benign paroxysmal positional vertigo patients. ( 29042068 )
2018
3
Benign paroxysmal positional vertigo in patients after mild traumatic brain injury. ( 30058780 )
2018
4
Fourth ventricle ependymoma mimicking benign paroxysmal positional vertigo. ( 30104227 )
2018
5
Benign paroxysmal positional vertigo in spontaneous intracranial hypotension. ( 30052143 )
2018
6
Subjective benign paroxysmal positional vertigo in patients with osteoporosis or migraine. ( 30482521 )
2018
7
Osteoporosis increases the risk of benign paroxysmal positional vertigo: a nested case-control study using a national sample cohort. ( 30511104 )
2018
8
Benign paroxysmal positional vertigo and osteoporosis. ( 30554357 )
2018
9
The prevalence of benign paroxysmal positional vertigo in patients with osteoporosis. ( 30315360 )
2018
10
Idiopathic benign paroxysmal positional vertigo with persistent vertigo/dizziness sensation is associated with latent canal paresis, endolymphatic hydrops, and osteoporosis. ( 30042018 )
2018
11
Teaching Patient-Centered Counseling Skills for Assessment, Diagnosis, and Management of Benign Paroxysmal Positional Vertigo. ( 29422713 )
2018
12
Successful management of benign paroxysmal positional vertigo (BPPV) in a patient who was ventilated with a C3 complete spinal injury on a regional spinal unit intensive care. ( 29437815 )
2018
13
Analysis of effect of 1α-hydroxyvitamin D3 on benign paroxysmal positional vertigo and risk factors. ( 29456639 )
2018
14
Utility of the bow and lean test in predicting subtype of benign paroxysmal positional vertigo. ( 29481705 )
2018
15
Analysis of non-posterior canal benign paroxysmal positional vertigo in patients treated using the particle repositioning chair: A large, single-institution series. ( 29544670 )
2018
16
The aVOR App Increases Medical Students' Competence in Treating Benign Paroxysmal Positional Vertigo (BPPV). ( 29579015 )
2018
17
Presence of Anxiety and Depression Symptoms Affects the First Time Treatment Efficacy and Recurrence of Benign Paroxysmal Positional Vertigo. ( 29619005 )
2018
18
Recurrence in Benign Paroxysmal Positional Vertigo: A Large, Single-Institution Study. ( 29649052 )
2018
19
The Necessity for Post-Maneuver Restrictions in the Treatment of Benign Paroxysmal Positional Vertigo: An Updated Meta-Analysis of the Literature. ( 29697583 )
2018
20
Treatment of Patients With Benign Paroxysmal Positional Vertigo and Severe Immobility Using the Particle Repositioning Chair: A Retrospective Cohort Study. ( 29732909 )
2018
21
Fracture probability assessed using FRAX® in elderly women with benign paroxysmal positional vertigo. ( 29784241 )
2018
22
Incidence and Clinical Significance of Positional Downbeat Nystagmus in Posterior Canal Benign Paroxysmal Positional Vertigo. ( 29856161 )
2018
23
Benign Paroxysmal Positional Vertigo After Piezosurgical Removal of Osseointegrated Implants. ( 29877981 )
2018
24
Assessment of sleep quality in benign paroxysmal positional vertigo recurrence. ( 29883234 )
2018
25
Otolithic damage study in patients with benign paroxysmal positional vertigo with vestibular evoked myogenic potentials. ( 29895391 )
2018
26
Comparison of automatic and manual reposition treatment for horizontal semicircular canal benign paroxysmal positional vertigo. ( 29921405 )
2018
27
Efficacy of SRM-IV Vestibular Function Diagnosis and Treatment System in Treating Benign Paroxysmal Positional Vertigo. ( 29922605 )
2018
28
Efficacy of Repositioning Therapy in Patients With Benign Paroxysmal Positional Vertigo and Preexisting Central Neurologic Disorders. ( 30013505 )
2018
29
The Effects of the Vestibular Rehabilitation on the Benign Paroxysmal Positional Vertigo Recurrence Rate in Patients with Otolith Dysfunction. ( 30016856 )
2018
30
Patient, disease, and outcome characteristics of benign paroxysmal positional vertigo with and without Meniere's disease. ( 30016894 )
2018
31
Comparison of the effectiveness of Brandt-Daroff Vestibular training and Epley Canalith repositioning maneuver in benign Paroxysmal positional vertigo long term result: A randomized prospective clinical trial. ( 30034415 )
2018
32
Anxiety, Mood, and Personality Disorders in Patients with Benign Paroxysmal Positional Vertigo. ( 30042641 )
2018
33
Therapeutic efficacy of the Galletti-Contrino manoeuvre for benign paroxysmal positional vertigo of vertical semicircular canals in overweight subjects. ( 30097716 )
2018
34
Spontaneous Canalith Jam and Apogeotropic Horizontal Canal Benign Paroxysmal Positional Vertigo: Considerations on a Particular Case Mimicking an Acute Vestibular Deficit. ( 30106853 )
2018
35
Assessment of Physician Adherence to Guidelines for the Diagnosis and Treatment of Benign Paroxysmal Positional Vertigo in Ambulatory Care Settings. ( 30128474 )
2018
36
Asking about dizziness when turning in bed predicts examination findings for benign paroxysmal positional vertigo. ( 30149484 )
2018
37
Benign paroxysmal positional vertigo associated with Meniere's disease. ( 30149485 )
2018
38
Assessment of a Statistical Algorithm for the Prediction of Benign Paroxysmal Positional Vertigo. ( 30178063 )
2018
39
Analyses with the Video Head Impulse Test During the Canalith Repositioning Maneuver in Patients with Isolated Posterior Semicircular Canal Benign Paroxysmal Positional Vertigo. ( 30197804 )
2018
40
Anterior Canal benign paroxysmal positional Vertigo following surgical Management of superior canal dehiscence. ( 30224218 )
2018
41
Tumarkin-like phenomenon as a sign of therapeutic success in benign paroxysmal positional vertigo. ( 30231127 )
2018
42
Assessment of Bone Metabolism in Male Patients With Benign Paroxysmal Positional Vertigo. ( 30233488 )
2018
43
Causes of Persistent Positional Vertigo Following Posterior Semicircular Canal Occlusion for Benign Paroxysmal Positional Vertigo. ( 30239433 )
2018
44
Evaluation of Benign Paroxysmal Positional Vertigo in American Football Players. ( 30256203 )
2018
45
Oxidative Status in Patients with Benign Paroxysmal Positional Vertigo. ( 30256204 )
2018
46
Vestibular dysfunction, beyond benign paroxysmal positional vertigo, affects mental rotations: Comment on "Visual dependence and spatial orientation in benign paroxysmal positional vertigo". ( 30282384 )
2018
47
Association of benign paroxysmal positional vertigo with vitamin D deficiency: a systematic review and meta-analysis. ( 30302575 )
2018
48
Diagnosis and treatment of anterior canal benign paroxysmal positional vertigo. ( 30318958 )
2018
49
Recovery of positional nystagmus after benign paroxysmal positional vertigo fatigue. ( 30324405 )
2018
50
Physical Therapy for Posterior and Horizontal Canal Benign Paroxysmal Positional Vertigo: Long-term Effect and Recurrence: A Systematic Review. ( 30357032 )
2018
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Variations for Benign Paroxysmal Positional Nystagmus

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Expression for Benign Paroxysmal Positional Nystagmus

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Search GEO for disease gene expression data for Benign Paroxysmal Positional Nystagmus.
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Pathways for Benign Paroxysmal Positional Nystagmus

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GO Terms for Benign Paroxysmal Positional Nystagmus

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Sources for Benign Paroxysmal Positional Nystagmus

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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