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MCID: BNG018
MIFTS: 40

Benign Paroxysmal Positional Nystagmus

Categories: Ear diseases, Genetic diseases, Rare diseases
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs
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Aliases & Classifications for Benign Paroxysmal Positional Nystagmus

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MalaCards integrated aliases for Benign Paroxysmal Positional Nystagmus:

Name: Benign Paroxysmal Positional Nystagmus 12 15
Benign Paroxysmal Positional Vertigo 12 77 54 45 64 74
Familial Benign Recurrent Vertigo 54
Familial Vestibulopathy 54
Bppv 54

Classifications:

MalaCards categories:
Global: Rare diseases Genetic diseases
Anatomical: Ear diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:13941
ICD9CM 36 386.11
MeSH 45 D065635
UMLS 74 C0155502
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Summaries for Benign Paroxysmal Positional Nystagmus

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PubMed Health : 64 About benign paroxysmal positional vertigo: Vertigo can be described as a kind of dizziness that makes it feel like everything is spinning around or moving. It can occur while standing, walking or lying down. Depending on what’s causing the dizziness, the length of an episode can vary greatly, and may be accompanied by drowsiness, nausea or other symptoms.The most common cause of this type of vertigo is benign paroxysmal positional vertigo (BPPV). Here certain movements cause dizziness for a short time. BPPV is quite easy to diagnose and treat.

MalaCards based summary : Benign Paroxysmal Positional Nystagmus, also known as benign paroxysmal positional vertigo, is related to vertigo, benign recurrent and osteoporosis, and has symptoms including vertigo, vertigo/dizziness and cupulolithiasis. An important gene associated with Benign Paroxysmal Positional Nystagmus is CACNA1A (Calcium Voltage-Gated Channel Subunit Alpha1 A). The drugs Calcium Carbonate and Vitamin D3 have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and brain.

Wikipedia : 77 Benign paroxysmal positional vertigo (BPPV) is a disorder arising from a problem in the inner ear.... more...

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Related Diseases for Benign Paroxysmal Positional Nystagmus

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Diseases related to Benign Paroxysmal Positional Nystagmus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Related Disease Score Top Affiliating Genes
1 vertigo, benign recurrent 12.3
2 osteoporosis 10.6
3 pathologic nystagmus 10.5
4 bone mineral density quantitative trait locus 8 10.5
5 bone mineral density quantitative trait locus 15 10.5
6 sudden sensorineural hearing loss 10.5
7 anxiety 10.5
8 thyroiditis 10.3
9 bornholm eye disease 10.2
10 inner ear disease 10.2
11 meniere disease 10.2
12 migraine with or without aura 1 10.1
13 spondyloarthropathy 1 10.1
14 epidermoid cysts 10.1
15 scleroderma, familial progressive 10.1
16 spinocerebellar ataxia 6 10.1
17 aging 10.1
18 orthostatic intolerance 10.1
19 nasopharyngeal carcinoma 10.1
20 meningioma, familial 10.1
21 hydrocephalus 10.1
22 spinal cord injury 10.1
23 cholesteatoma of middle ear 10.1
24 spinal meningioma 10.1
25 otosclerosis 10.1
26 acoustic neuroma 10.1
27 dementia 10.1
28 autosomal dominant cerebellar ataxia 10.1
29 personality disorder 10.1
30 hyperinsulinism 10.1
31 auditory system disease 10.1
32 neurilemmoma 10.1
33 ischemia 10.1
34 hyperglycemia 10.1
35 secretory meningioma 10.1
36 intracranial hypotension 10.1
37 benign ependymoma 10.1
38 spondylitis 10.1
39 broken heart syndrome 10.1
40 congenital hydrocephalus 10.1
41 ependymoma 10.1
42 lymphomatous thyroiditis 10.1
43 perilymphatic fistula 10.1
44 pure autonomic failure 10.1
45 depression 10.1
46 syncope 10.1
47 spontaneous intracranial hypotension 10.1
48 deafness, autosomal recessive 4, with enlarged vestibular aqueduct 10.0
49 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.0
50 brain injury 10.0

Graphical network of the top 20 diseases related to Benign Paroxysmal Positional Nystagmus:



Diseases related to Benign Paroxysmal Positional Nystagmus
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Symptoms & Phenotypes for Benign Paroxysmal Positional Nystagmus

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UMLS symptoms related to Benign Paroxysmal Positional Nystagmus:


vertigo, vertigo/dizziness, cupulolithiasis
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Drugs & Therapeutics for Benign Paroxysmal Positional Nystagmus

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PubMedHealth treatment related to Benign Paroxysmal Positional Nystagmus: 64

“Repositioning” procedures or maneuvers are commonly used to treat BPPV. They involve moving the patient into specific lying or sitting positions following a certain sequence, with specific positions of the head. The sequence of movements is designed to help move the tiny crystals out of the posterior semicircular canal and into areas of the vestibular system where they can no longer disturb the sensory hair cells.The Epley maneuver and the Semont maneuver are two very simple and effective repositioning procedures for the treatment of BPPV caused by crystals in the posterior semicircular canal. These maneuvers are typically done several times with the help of a doctor. There are also slightly modified repositioning procedures that can be done at home in addition to the doctor-assisted maneuvers.The crystals are only rarely found in either of the other semicircular canals. Then other repositioning maneuvers can be used.Medication can help if the vertigo is causing nausea.If the symptoms persist, surgery on the vestibular system may be considered. This involves destroying either the nerve fibers that are connected to the affected semicircular canal, or the semicircular canal itself. The hair cells can then no longer transmit misleading information – or any other information – to the brain. This means that the vestibular system in that ear is permanently affected by the surgery.

Drugs for Benign Paroxysmal Positional Nystagmus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 52)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Calcium Carbonate Approved, Investigational Phase 4 471-34-1
2
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 5280795 6221
3
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
4
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
5
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
6 Calciferol Phase 4
7 Vitamins Phase 4
8 Trace Elements Phase 4
9 Ergocalciferols Phase 4
10 Micronutrients Phase 4
11 Bone Density Conservation Agents Phase 4
12 Gastrointestinal Agents Phase 4,Not Applicable
13 Vitamin D2 Phase 4
14 Calcium Supplement Phase 4
15 Anti-Ulcer Agents Phase 4
16 Antacids Phase 4
17 Hormones Phase 4
18 Nutrients Phase 4
19 Calcium, Dietary Phase 4
20
Histamine Approved, Investigational Not Applicable 51-45-6 774
21
Lorazepam Approved Not Applicable 846-49-1 3958
22
Promethazine Approved, Investigational Not Applicable 60-87-7 4927
23
Meclizine Approved Not Applicable 569-65-3 4034
24
Diphenhydramine Approved, Investigational Not Applicable 147-24-0, 58-73-1 3100
25
Ondansetron Approved Not Applicable 99614-02-5 4595
26
Diazepam Approved, Illicit, Investigational, Vet_approved Not Applicable 439-14-5 3016
27
Betahistine Approved, Investigational Not Applicable 5638-76-6 2366
28 Autonomic Agents Not Applicable
29 Antipsychotic Agents Not Applicable
30 Central Nervous System Depressants Not Applicable
31 GABA Modulators Not Applicable
32 Antiemetics Not Applicable
33 Dermatologic Agents Not Applicable
34
Histamine Phosphate Not Applicable 51-74-1 65513
35 Anesthetics Not Applicable
36 Anesthetics, Local Not Applicable
37 GABA Agents Not Applicable
38 Serotonin Antagonists Not Applicable
39 Histamine H1 Antagonists Not Applicable
40 Peripheral Nervous System Agents Not Applicable
41 Neurotransmitter Agents Not Applicable
42 Anti-Allergic Agents Not Applicable
43 Histamine Antagonists Not Applicable
44 Psychotropic Drugs Not Applicable
45 Antipruritics Not Applicable
46 Hypnotics and Sedatives Not Applicable
47 Anti-Anxiety Agents Not Applicable
48 Tranquilizing Agents Not Applicable
49 Serotonin Agents Not Applicable
50 Anticonvulsants Not Applicable

Interventional clinical trials:

(show all 36)
# Name Status NCT ID Phase Drugs
1 Efficacy of Vitamin D and Calcium Supplementation on the Prevention of Recurrences in BPPV Completed NCT02031692 Phase 4 400IU cholecalciferol and 500mg of elemental calcium as calcium carbonate
2 The Treatment of Posterior Semicircular Canal Benign Paroxysmal Positional Vertigo Completed NCT02029508 Phase 3
3 Treatment of Geotropic Horizontal Canal Benign Paroxysmal Positional Vertigo Completed NCT01366430 Phase 3
4 Treatment of Apogeotropic Horizontal Canal Benign Paroxysmal Positional Vertigo Completed NCT00810641 Phase 3
5 Canalith Repositioning Procedure for BPPV in Primary Care Completed NCT00182273 Phase 3
6 Visual Feedback Goggle for Positional Vertigo Treatment Unknown status NCT00729885 Phase 1, Phase 2
7 Treatment of Apogeotropic Horizontal Canal Benign Paroxysmal Positional Vertigo Completed NCT02046980 Phase 2
8 Treatments for Benign Paroxysmal Positional Vertigo (BPPV) Completed NCT00000359 Phase 2
9 Efficacy of Postural Restriction in Treating Benign Paroxysmal Positional Vertigo Unknown status NCT02475239 Not Applicable
10 Treatment of Posterior Canal Type of Benign Paroxysmal Positional Vertigo Unknown status NCT01822002 Not Applicable
11 The Liberatory Maneuver for the Treatment of Benign Paroxysmal Positional Vertigo (BPPV) Unknown status NCT01008124 Not Applicable
12 Comparison of Home-Based Exercise on the Posterior Canal Benign Paroxysmal Positional Vertigo Symptoms Completed NCT03230513 Not Applicable
13 Cranial Osteopathic Techniques on the Symptoms of Benign Paroxysmal Positional Vertigo Completed NCT03854084 Not Applicable
14 Evidence Based Best Care Practice for Benign Paroxysmal Positional Vertigo Completed NCT02809599 Not Applicable
15 Treating Benign Paroxysmal Positional Vertigo (BPPV) in ED Patients Completed NCT00641797 Not Applicable Meclizine;Lorazepam;Diphenhydramine;Ondansetron
16 Vestibular Evoked Myogenic Potentials in Benign Paroxysmal Positional Vertigo (VEMP in BPPV) Completed NCT01004913
17 BPPV Treatment in Biaxial Rotational Chair Completed NCT01905800 Not Applicable
18 Clinical Aspects of Patients With Benign Paroxysmal Positional Vertigo (BPPV) and Migraine Completed NCT02615314
19 Effectiveness of the Epley Manoeuvre Performed in Primary Care to Treat Benign Paroxysmal Positional Vertigo Completed NCT01969513 Not Applicable
20 Effectiveness of Osteopathic Manipulative Treatment (OMT) and Vestibular Rehabilitation Therapy (VRT) in Individuals With Vertigo Completed NCT01529151 Not Applicable
21 To Study the Characteristics of Different Types of Vertigo in Patients Attending the Ear Nose & Throat (ENT) Clinics. Completed NCT02213120
22 Osteotome Sinus Floor Elevation With or Without Grafting Completed NCT01619956 Not Applicable
23 Sinus Lift: Saving Time and Reducing Morbidity Completed NCT02415946 Not Applicable
24 Different Treatments With the TRV Reposition Chair Recruiting NCT03541018 Not Applicable
25 BPPV With CRP: Single Versus Multiple Cycles Recruiting NCT02701218 Not Applicable
26 Inactivity, Balance Problems and Fall Risk in Institutionalized Frail Elderly Recruiting NCT02905292
27 Interventions for Residual Dizziness After Successful Repositioning Maneuvers in Patients With BPPV Recruiting NCT03624283 Not Applicable Betahistine
28 3D Model of Posterior Membranous Labyrinth of the Inner Ear Recruiting NCT03295929
29 Acute Video-oculography for Vertigo in Emergency Rooms for Rapid Triage (AVERT) Recruiting NCT02483429 Not Applicable
30 Clinical Evaluation of Two Types of Transalveolar Sinus Floor Elevation Recruiting NCT03445039 Not Applicable
31 Efficacy of a Mechanical Chair for Treatment of Benign Paroxysmal Positional Vertigo (BPPV) Enrolling by invitation NCT03161470 Not Applicable
32 TRV-chair vs Manual Repositioning Maneuver in Treatment of Benign Paroxysmal Positional Vertigo Enrolling by invitation NCT03871413 Not Applicable
33 Benign Paroxysmal Positional Vertigo (BPPV) Training for Sports Medicine Providers in a Pediatric Concussion Program Not yet recruiting NCT03425786 Not Applicable
34 Evaluation of the Prevalence of BPPV and Longterm Effects of Its Therapy Using the Rotundum Device in Retirement Homes Not yet recruiting NCT03643354 Not Applicable
35 The Influence of Vestibular Stimulation on Cardiac Autonomic Control System in Subjects With and Without BPPV Not yet recruiting NCT03867019
36 Effects of Physical Treatment on Postural Stability in Benign Paroxysmal Positional Vertigo (BPPV) Patients Withdrawn NCT00978809 Not Applicable

Search NIH Clinical Center for Benign Paroxysmal Positional Nystagmus

Cochrane evidence based reviews: benign paroxysmal positional vertigo

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Genetic Tests for Benign Paroxysmal Positional Nystagmus

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Anatomical Context for Benign Paroxysmal Positional Nystagmus

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MalaCards organs/tissues related to Benign Paroxysmal Positional Nystagmus:

42
Testes, Bone, Brain, Thyroid, Spinal Cord, Cerebellum, Eye
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Publications for Benign Paroxysmal Positional Nystagmus

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Articles related to Benign Paroxysmal Positional Nystagmus:

(show top 50) (show all 873)
# Title Authors Year
1
Effects of treatment on anxiety levels among patients with benign paroxysmal positional vertigo. ( 30666439 )
2019
2
Otolith dysfunction in recurrent benign paroxysmal positional vertigo after mild traumatic brain injury. ( 30714506 )
2019
3
Increased risk of benign paroxysmal positional vertigo in osteoporosis: a nationwide population-based cohort study. ( 30837524 )
2019
4
Idiopathic benign paroxysmal positional vertigo with persistent vertigo/dizziness sensation is associated with latent canal paresis, endolymphatic hydrops, and osteoporosis. ( 30042018 )
2019
5
Association Between Migraine and Benign Paroxysmal Positional Vertigo Among Adults in South Korea. ( 30676633 )
2019
6
Benign paroxysmal positional vertigo in children. ( 30220115 )
2019
7
Early experience with a multi-axial, whole body positioning system in the treatment of Benign Paroxysmal Positional Vertigo (BPPV). ( 30377044 )
2019
8
Effectiveness of the Epley manoeuvre in posterior canal benign paroxysmal positional vertigo: a randomised clinical trial in primary care. ( 30510098 )
2019
9
Increased Risk of Benign Paroxysmal Positional Vertigo in Patients With a History of Sudden Sensory Neural Hearing Loss: A Longitudinal Follow-up Study Using a National Sample Cohort. ( 30624405 )
2019
10
Clinical features of benign paroxysmal positional vertigo of the posterior semicircular canal. ( 30637105 )
2019
11
Analysis of cost and effectiveness of treatment in benign paroxysmal positional vertigo. ( 30681502 )
2019
12
Poor Treatment Outcomes Following Repositioning Maneuvers in Younger and Older Adults With Benign Paroxysmal Positional Vertigo: A Systematic Review and Meta-analysis. ( 30691621 )
2019
13
Diagnosis and treatment choices of suspected benign paroxysmal positional vertigo: current approach of general practitioners, neurologists, and ENT physicians. ( 30694376 )
2019
14
Correlations of Calcium Voltage-Gated Channel Subunit Alpha1 A (CACNA1A) Gene Polymorphisms with Benign Paroxysmal Positional Vertigo. ( 30710491 )
2019
15
Sitting Up Vertigo. Proposed Variant of Posterior Canal Benign Paroxysmal Positional Vertigo. ( 30807523 )
2019
16
Serum Vitamin D and Long-Term Outcomes of Benign Paroxysmal Positional Vertigo. ( 30813712 )
2019
17
Association Between Serum Uric Acid Levels and Benign Paroxysmal Positional Vertigo: A Systematic Review and Meta-Analysis of Observational Studies. ( 30828314 )
2019
18
Benign paroxysmal positional vertigo. ( 30828628 )
2019
19
Sitting Up Vertigo. Proposed Variant of Posterior Canal Benign Paroxysmal Positional Vertigo. ( 30870365 )
2019
20
Difference in Serum Levels of Vitamin D Between Canalolithiasis and Cupulolithiasis of the Horizontal Semicircular Canal in Benign Paroxysmal Positional Vertigo. ( 30881337 )
2019
21
Impaired Calcium Metabolism in Benign Paroxysmal Positional Vertigo: A Topical Review. ( 30883492 )
2019
22
Effect of Epley, Semont Maneuvers and Brandt-Daroff Exercise on Quality of Life in Patients with Posterior Semicircular Canal Benign Paroxysmal Positional Vertigo (PSCBPPV). ( 30906723 )
2019
23
Risk of benign paroxysmal positional vertigo in patients with depressive disorders: a nationwide population-based cohort study. ( 30928959 )
2019
24
Investigation of self-reported dizziness in the elderly when lying down or turning over in bed, and possible benign paroxysmal positional vertigo. ( 30929651 )
2019
25
Benign Paroxysmal Positional Vertigo. ( 30947198 )
2019
26
Identification of Factors Related to Cases of Benign Paroxysmal Positional Vertigo Refractory to Canalicular Repositioning Maneuvers and Evaluation of the Need for Magnetic Resonance Imaging in their Management: Retrospective Analysis of a Series of 176 Cases. ( 30956705 )
2019
27
Seasonality and solar radiation variation level in benign paroxysmal positional vertigo. ( 30957689 )
2019
28
Serum levels of 25-hydroxy vitamin D correlate with idiopathic benign paroxysmal positional vertigo. ( 30962270 )
2019
29
Diagnosis strategy and Yacovino maneuver for anterior canal-benign paroxysmal positional vertigo. ( 30963252 )
2019
30
Optimal reassessment time for treatment response in posterior canal benign paroxysmal positional vertigo. ( 30982972 )
2019
31
Association between bone mineral density and benign paroxysmal positional vertigo: a meta-analysis. ( 31030242 )
2019
32
Post-traumatic benign paroxysmal positional vertigo. ( 31048363 )
2019
33
Persistent Upbeat Positional Nystagmus in a Patient with Bilateral Posterior Canal Benign Paroxysmal Positional Vertigo. ( 31049238 )
2019
34
Reposition Chair Treatment Improves Subjective Outcomes in Refractory Benign Paroxysmal Positional Vertigo. ( 31058604 )
2019
35
A new treatment (the affected-ear-up 90° maneuver) for benign paroxysmal positional vertigo of the lateral semicircular canal. ( 31066612 )
2019
36
Developing a Diagnostic Decision Support System for Benign Paroxysmal Positional Vertigo Using a Deep-Learning Model. ( 31072056 )
2019
37
Caloric tests in clinical practice in benign paroxysmal positional vertigo. ( 31099297 )
2019
38
Incidence and Clinical Significance of Positional Downbeat Nystagmus in Posterior Canal Benign Paroxysmal Positional Vertigo. ( 29856161 )
2019
39
Otolithic damage study in patients with benign paroxysmal positional vertigo with vestibular evoked myogenic potentials. ( 29895391 )
2019
40
Aging Is a Risk Factor for Utricular Dysfunction in Idiopathic Benign Paroxysmal Positional Vertigo. ( 30559714 )
2018
41
Anxiety, Mood, and Personality Disorders in Patients with Benign Paroxysmal Positional Vertigo. ( 30042641 )
2018
42
Benign paroxysmal positional vertigo in patients after mild traumatic brain injury. ( 30058780 )
2018
43
Fourth ventricle ependymoma mimicking benign paroxysmal positional vertigo. ( 30104227 )
2018
44
Benign paroxysmal positional vertigo in spontaneous intracranial hypotension. ( 30052143 )
2018
45
Benign paroxysmal positional vertigo and osteoporosis. ( 30554357 )
2018
46
Subjective benign paroxysmal positional vertigo in patients with osteoporosis or migraine. ( 30482521 )
2018
47
Osteoporosis increases the risk of benign paroxysmal positional vertigo: a nested case-control study using a national sample cohort. ( 30511104 )
2018
48
The prevalence of benign paroxysmal positional vertigo in patients with osteoporosis. ( 30315360 )
2018
49
Analyses with the Video Head Impulse Test During the Canalith Repositioning Maneuver in Patients with Isolated Posterior Semicircular Canal Benign Paroxysmal Positional Vertigo. ( 30197804 )
2018
50
Anterior Canal benign paroxysmal positional Vertigo following surgical Management of superior canal dehiscence. ( 30224218 )
2018
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Variations for Benign Paroxysmal Positional Nystagmus

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Expression for Benign Paroxysmal Positional Nystagmus

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Search GEO for disease gene expression data for Benign Paroxysmal Positional Nystagmus.
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Pathways for Benign Paroxysmal Positional Nystagmus

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GO Terms for Benign Paroxysmal Positional Nystagmus

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Biological processes related to Benign Paroxysmal Positional Nystagmus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of neuron apoptotic process GO:0043524 8.96 CACNA1A EN1
2 synapse assembly GO:0007416 8.62 CACNA1A PCLO
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Sources for Benign Paroxysmal Positional Nystagmus

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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