MCID: BNG029
MIFTS: 31

Benign Struma Ovarii

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Benign Struma Ovarii

MalaCards integrated aliases for Benign Struma Ovarii:

Name: Benign Struma Ovarii 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:5209
NCIt 51 C40012
UMLS 74 C1511104

Summaries for Benign Struma Ovarii

Disease Ontology : 12 A struma ovarii that is not cancerous.

MalaCards based summary : Benign Struma Ovarii is related to struma ovarii and thyroid cancer. An important gene associated with Benign Struma Ovarii is TSHR (Thyroid Stimulating Hormone Receptor), and among its related pathways/superpathways are Allograft rejection and Endometrial cancer. Affiliated tissues include thyroid, t cells and lung, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Benign Struma Ovarii

Diseases in the Struma Ovarii family:

Malignant Struma Ovarii Benign Struma Ovarii

Diseases related to Benign Struma Ovarii via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 struma ovarii 30.5 RET TG TSHR
2 thyroid cancer 29.1 HRAS NRAS RET TG TSHR
3 graves' disease 10.4
4 thyroid cancer, nonmedullary, 1 10.2
5 pseudo-meigs syndrome 10.2
6 goiter 10.2 TG TSHR
7 athyreosis 10.1 TG TSHR
8 endemic goiter 10.1 TG TSHR
9 postsurgical hypothyroidism 10.1 TG TSHR
10 hypothyroidism, congenital, nongoitrous, 2 10.1 TG TSHR
11 graves disease 1 10.1 TG TSHR
12 nontoxic goiter 10.1 TG TSHR
13 myxedema 10.1 TG TSHR
14 toxic diffuse goiter 10.1 TG TSHR
15 subacute thyroiditis 10.1 TG TSHR
16 papillary thyroid microcarcinoma 10.1 TG TSHR
17 exophthalmos 10.1 TG TSHR
18 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0 TG TSHR
19 giant congenital nevus 10.0 HRAS NRAS
20 schimmelpenning-feuerstein-mims syndrome 10.0 HRAS NRAS
21 autoimmune disease of endocrine system 10.0 TG TSHR
22 ovarian melanoma 10.0 HRAS NRAS
23 malignant conjunctival melanoma 10.0 HRAS NRAS
24 melanomatosis 10.0 HRAS NRAS
25 marcus gunn phenomenon 10.0 HRAS NRAS
26 nodular malignant melanoma 10.0 HRAS NRAS
27 myelodysplastic myeloproliferative cancer 10.0 HRAS NRAS
28 meningeal melanomatosis 10.0 HRAS NRAS
29 melanocytic nevus syndrome, congenital 10.0 HRAS NRAS
30 acneiform dermatitis 10.0 HRAS NRAS
31 vulvar melanoma 10.0 HRAS NRAS
32 malignant skin fibrous histiocytoma 10.0 HRAS NRAS
33 cell type benign neoplasm 10.0 HRAS TG
34 core binding factor acute myeloid leukemia 10.0 HRAS NRAS
35 liver angiosarcoma 10.0 HRAS NRAS
36 malignant dermis tumor 10.0 HRAS NRAS
37 central nervous system melanocytic neoplasm 10.0 HRAS NRAS
38 nevus, epidermal 9.9 HRAS NRAS
39 ovarian germ cell cancer 9.9 RET TG
40 hyperthyroidism 9.9 TG TSHR
41 ovarian serous cystadenocarcinoma 9.9 HRAS NRAS
42 leukemia, chronic lymphocytic 2 9.9 HRAS NRAS
43 sporadic pheochromocytoma 9.9 HRAS RET
44 renal cell carcinoma, papillary, 1 9.9 HRAS NRAS
45 multinodular goiter 9.8 HRAS TG TSHR
46 adenosquamous lung carcinoma 9.8 HRAS RET
47 congenital hypothyroidism 9.8 TG TSHR
48 neurofibromatosis, type iv, of riccardi 9.8 HRAS RET
49 colonic disease 9.8 HRAS RET
50 fetal adenoma 9.8 HRAS NRAS TG

Graphical network of the top 20 diseases related to Benign Struma Ovarii:



Diseases related to Benign Struma Ovarii

Symptoms & Phenotypes for Benign Struma Ovarii

GenomeRNAi Phenotypes related to Benign Struma Ovarii according to GeneCards Suite gene sharing:

27 (show all 18)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.73 NRAS
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-160 9.73 RET
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.73 NRAS
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.73 RET
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-28 9.73 HRAS NRAS RET
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.73 RET
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.73 HRAS
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.73 NRAS
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.73 HRAS
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 9.73 HRAS
11 Decreased viability GR00055-A-2 9.47 HRAS
12 Decreased viability GR00221-A-1 9.47 HRAS NRAS RET
13 Decreased viability GR00221-A-2 9.47 HRAS RET
14 Decreased viability GR00221-A-3 9.47 HRAS NRAS
15 Decreased viability GR00221-A-4 9.47 RET
16 Decreased viability GR00231-A 9.47 RET
17 Decreased viability GR00301-A 9.47 RET
18 Decreased viability GR00402-S-2 9.47 HRAS NRAS RET

MGI Mouse Phenotypes related to Benign Struma Ovarii:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.65 HRAS NRAS RET TG TSHR
2 digestive/alimentary MP:0005381 9.62 HRAS NRAS RET TG
3 growth/size/body region MP:0005378 9.55 HRAS NRAS RET TG TSHR
4 limbs/digits/tail MP:0005371 9.26 NRAS RET TG TSHR
5 neoplasm MP:0002006 8.92 HRAS NRAS RET TSHR

Drugs & Therapeutics for Benign Struma Ovarii

Search Clinical Trials , NIH Clinical Center for Benign Struma Ovarii

Genetic Tests for Benign Struma Ovarii

Anatomical Context for Benign Struma Ovarii

MalaCards organs/tissues related to Benign Struma Ovarii:

42
Thyroid, T Cells, Lung, Skin, Liver, Colon, Myeloid

Publications for Benign Struma Ovarii

Articles related to Benign Struma Ovarii:

# Title Authors Year
1
Coexistence of benign struma ovarii, pseudo-Meigs' syndrome and elevated serum CA 125: Case report and review of the literature. ( 25789033 )
2015
2
Coexistence of radioactive iodine-resistant benign struma ovarii with cervical primary papillary cancer of the thyroid: an unusual cause of thyroglobulin-positive radioactive iodine-negative whole-body scans. ( 24934079 )
2014
3
Coexistence of Graves' disease, papillary thyroid carcinoma and unilateral benign struma ovarii: case report and review of the literature. ( 23806737 )
2013
4
Benign struma ovarii in a patient with invasive papillary thyroid cancer: detection with I-131 SPECT-CT. ( 17452868 )
2007
5
Scintigraphic detection of benign struma ovarii in a hyperthyroid patient. ( 15917485 )
2005
6
Coexistence of Graves' disease and benign struma ovarii in a patient with marked ascites and elevated CA-125 levels. ( 16370564 )
2005
7
Benign struma ovarii complicating pregnancy: a case report and review of the literature. ( 12937924 )
2003

Variations for Benign Struma Ovarii

Expression for Benign Struma Ovarii

Search GEO for disease gene expression data for Benign Struma Ovarii.

Pathways for Benign Struma Ovarii

Pathways related to Benign Struma Ovarii according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.57 HRAS TG TSHR
2
Show member pathways
12.55 HRAS NRAS RET
3 12.52 HRAS NRAS RET
4
Show member pathways
11.77 HRAS NRAS RET
5 11.65 HRAS NRAS
6
Show member pathways
11.61 HRAS NRAS
7
Show member pathways
11.59 HRAS NRAS
8 11.58 HRAS NRAS
9 11.48 HRAS NRAS
10 11.44 HRAS TSHR
11 11.42 HRAS NRAS
12
Show member pathways
11.41 HRAS NRAS
13 11.37 HRAS NRAS
14 11.34 HRAS NRAS
15
Show member pathways
11.25 HRAS NRAS RET
16 11.21 HRAS NRAS
17 11.14 HRAS RET
18 11.13 HRAS RET
19 11.07 HRAS NRAS
20 11.06 HRAS NRAS
21 11 HRAS NRAS
22 10.99 HRAS NRAS
23
Show member pathways
10.96 HRAS NRAS
24 10.94 HRAS NRAS RET
25
Show member pathways
10.89 HRAS NRAS
26 10.82 HRAS NRAS
27 10.78 HRAS NRAS
28 10.71 HRAS NRAS
29 10.48 HRAS NRAS RET
30 10.44 HRAS NRAS
31 10.03 HRAS RET
32 10.03 TG TSHR

GO Terms for Benign Struma Ovarii

Biological processes related to Benign Struma Ovarii according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Ras protein signal transduction GO:0007265 9.26 HRAS NRAS
2 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.16 HRAS NRAS
3 MAPK cascade GO:0000165 9.13 HRAS NRAS RET
4 signal transduction GO:0007165 9.02 HRAS NRAS RET TG TSHR

Molecular functions related to Benign Struma Ovarii according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleotide binding GO:0000166 8.8 HRAS NRAS RET

Sources for Benign Struma Ovarii

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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