MCID: BNG029
MIFTS: 30

Benign Struma Ovarii

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Benign Struma Ovarii

MalaCards integrated aliases for Benign Struma Ovarii:

Name: Benign Struma Ovarii 12 15 72

Classifications:



External Ids:

Disease Ontology 12 DOID:5209
NCIt 50 C40012
UMLS 72 C1511104

Summaries for Benign Struma Ovarii

Disease Ontology : 12 A struma ovarii that is not cancerous.

MalaCards based summary : Benign Struma Ovarii is related to hyperthyroidism and struma ovarii. An important gene associated with Benign Struma Ovarii is TSHR (Thyroid Stimulating Hormone Receptor), and among its related pathways/superpathways are Allograft rejection and Endometrial cancer. Affiliated tissues include thyroid, ovary and breast, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Benign Struma Ovarii

Diseases in the Struma Ovarii family:

Malignant Struma Ovarii Benign Struma Ovarii

Diseases related to Benign Struma Ovarii via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Related Disease Score Top Affiliating Genes
1 hyperthyroidism 30.3 TSHR TG
2 struma ovarii 30.2 TSHR TG RET
3 ovarian germ cell teratoma 29.6 TG RET NRAS
4 malignant struma ovarii 28.6 TG RET NRAS HRAS
5 teratoma 10.5
6 teratoma, ovarian 10.4
7 graves' disease 10.4
8 thyroid carcinoma 10.4
9 goiter 10.2 TSHR TG
10 athyreosis 10.2 TSHR TG
11 endemic goiter 10.2 TSHR TG
12 ovarian cancer 10.2
13 thyroid cancer, nonmedullary, 1 10.2
14 thyroid gland papillary carcinoma 10.2
15 ovarian epithelial cancer 10.2
16 pseudo-meigs syndrome 10.2
17 malignant epithelial tumor of ovary 10.2
18 postsurgical hypothyroidism 10.2 TSHR TG
19 hypothyroidism, congenital, nongoitrous, 2 10.2 TSHR TG
20 nontoxic goiter 10.2 TSHR TG
21 graves disease 1 10.2 TSHR TG
22 subacute thyroiditis 10.2 TSHR TG
23 toxic diffuse goiter 10.2 TSHR TG
24 myxedema 10.2 TSHR TG
25 papillary thyroid microcarcinoma 10.1 TSHR TG
26 exophthalmos 10.1 TSHR TG
27 autoimmune disease of endocrine system 10.1 TSHR TG
28 giant congenital nevus 10.1 NRAS HRAS
29 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.1 TSHR TG
30 schimmelpenning-feuerstein-mims syndrome 10.1 NRAS HRAS
31 ovarian melanoma 10.1 NRAS HRAS
32 melanomatosis 10.1 NRAS HRAS
33 malignant conjunctival melanoma 10.1 NRAS HRAS
34 marcus gunn phenomenon 10.0 NRAS HRAS
35 nodular malignant melanoma 10.0 NRAS HRAS
36 meningeal melanomatosis 10.0 NRAS HRAS
37 melanocytic nevus syndrome, congenital 10.0 NRAS HRAS
38 acneiform dermatitis 10.0 NRAS HRAS
39 vulvar melanoma 10.0 NRAS HRAS
40 core binding factor acute myeloid leukemia 10.0 NRAS HRAS
41 cell type benign neoplasm 10.0 TG HRAS
42 malignant skin fibrous histiocytoma 10.0 NRAS HRAS
43 liver angiosarcoma 10.0 NRAS HRAS
44 malignant dermis tumor 9.9 NRAS HRAS
45 central nervous system melanocytic neoplasm 9.9 NRAS HRAS
46 nevus, epidermal 9.9 NRAS HRAS
47 ovarian germ cell cancer 9.9 TG RET
48 ovarian serous cystadenocarcinoma 9.8 NRAS HRAS
49 sporadic pheochromocytoma 9.8 RET HRAS
50 leukemia, chronic lymphocytic 2 9.8 NRAS HRAS

Graphical network of the top 20 diseases related to Benign Struma Ovarii:



Diseases related to Benign Struma Ovarii

Symptoms & Phenotypes for Benign Struma Ovarii

GenomeRNAi Phenotypes related to Benign Struma Ovarii according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.47 HRAS
2 Decreased viability GR00221-A-1 9.47 HRAS NRAS RET
3 Decreased viability GR00221-A-2 9.47 HRAS RET
4 Decreased viability GR00221-A-3 9.47 HRAS NRAS
5 Decreased viability GR00221-A-4 9.47 RET
6 Decreased viability GR00231-A 9.47 RET
7 Decreased viability GR00301-A 9.47 RET
8 Decreased viability GR00402-S-2 9.47 HRAS NRAS RET

MGI Mouse Phenotypes related to Benign Struma Ovarii:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.65 HRAS NRAS RET TG TSHR
2 digestive/alimentary MP:0005381 9.62 HRAS NRAS RET TG
3 growth/size/body region MP:0005378 9.55 HRAS NRAS RET TG TSHR
4 limbs/digits/tail MP:0005371 9.26 NRAS RET TG TSHR
5 neoplasm MP:0002006 8.92 HRAS NRAS RET TSHR

Drugs & Therapeutics for Benign Struma Ovarii

Search Clinical Trials , NIH Clinical Center for Benign Struma Ovarii

Genetic Tests for Benign Struma Ovarii

Anatomical Context for Benign Struma Ovarii

MalaCards organs/tissues related to Benign Struma Ovarii:

41
Thyroid, Ovary, Breast

Publications for Benign Struma Ovarii

Articles related to Benign Struma Ovarii:

(show all 33)
# Title Authors PMID Year
1
Struma Ovarii: A Report of Three Cases and Literature Review. 38
30692823 2018
2
Struma ovarii - ultrasound features of a rare tumor mimicking ovarian cancer. 38
30167590 2018
3
Struma Ovarii With Hyperthyroidism. 38
28394842 2017
4
Level of HE4 is Correlated with Diagnosis of Struma Ovarii: A Case Report. 38
27381498 2016
5
[Benign struma ovarii: Report of 7 cases and review of the literature]. 38
26997461 2016
6
Metastatic malignant struma ovarii with coexistence of Hashimoto's thyroiditis. 38
27224256 2016
7
Sonographic and Pathologic Features of Struma Ovarii. 38
26149143 2015
8
Coexistence of benign struma ovarii, pseudo-Meigs' syndrome and elevated serum CA 125: Case report and review of the literature. 38
25789033 2015
9
Struma ovarii complicating pregnancy: a case report. 38
26411234 2015
10
Struma ovarii: management and follow-up of a rare ovarian tumour. 38
25640097 2015
11
Coexistence of radioactive iodine-resistant benign struma ovarii with cervical primary papillary cancer of the thyroid: an unusual cause of thyroglobulin-positive radioactive iodine-negative whole-body scans. 38
24934079 2014
12
[Clinical study on 68 cases with struma ovarii]. 38
25169639 2014
13
Coexistence of Graves' disease, papillary thyroid carcinoma and unilateral benign struma ovarii: case report and review of the literature. 38
23806737 2013
14
Struma ovarii and the thyroid surgeon. 38
22624934 2012
15
Unilateral malignant struma ovarii in a case of bilateral ovarian teratoma with raised CA-125 level: a rare case with treatment dilemmas. 38
21934226 2011
16
Struma ovarii in breast cancer. 38
21505904 2011
17
Coexistence of struma ovarii with marked ascites and elevated CA-125 levels: case report and literature review. 38
18807056 2009
18
Bilateral benign non functional struma ovarii with Pseudo-Meigs' syndrome. 38
19136795 2009
19
Clinical characteristics of struma ovarii. 38
19471561 2008
20
Cystic struma ovarii presenting as pseudo-Meigs' syndrome with elevated CA125 levels. A case report and review of the literature. 38
18334015 2008
21
[Cystic struma ovarii, a rare form of ovarian tumor--case report, and review of the literature]. 38
18039620 2007
22
BRAF in papillary thyroid carcinoma of ovary (struma ovarii). 38
17721188 2007
23
Benign struma ovarii in a patient with invasive papillary thyroid cancer: detection with I-131 SPECT-CT. 38
17452868 2007
24
Incidental diagnosis of struma ovarii after thyroidectomy for thyroid cancer: functional imaging studies and follow-up. 38
16516952 2006
25
Struma ovarii showing clinical characteristics of ovarian malignancy. 38
16343201 2005
26
Coexistence of Graves' disease and benign struma ovarii in a patient with marked ascites and elevated CA-125 levels. 38
16370564 2005
27
Scintigraphic detection of benign struma ovarii in a hyperthyroid patient. 38
15917485 2005
28
Pseudo-Meigs syndrome and elevated CA125 associated with struma ovarii. 38
15790478 2005
29
Benign struma ovarii complicating pregnancy: a case report and review of the literature. 38
12937924 2003
30
An unusual presentation of struma ovarii mimicking a malignant process. 38
12423825 2002
31
Metastatic thyroid carcinoma in the presence of struma ovarii. 38
11700816 2001
32
Struma ovarii. 38
7901063 1993
33
Limitations of CA125 in the preoperative evaluation of a pelvic mass: struma ovarii and ascites. 38
8216132 1993

Variations for Benign Struma Ovarii

Expression for Benign Struma Ovarii

Search GEO for disease gene expression data for Benign Struma Ovarii.

Pathways for Benign Struma Ovarii

Pathways related to Benign Struma Ovarii according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.56 TSHR TG HRAS
2
Show member pathways
12.55 RET NRAS HRAS
3 12.52 RET NRAS HRAS
4
Show member pathways
11.77 RET NRAS HRAS
5 11.65 NRAS HRAS
6
Show member pathways
11.59 NRAS HRAS
7 11.58 NRAS HRAS
8 11.48 NRAS HRAS
9 11.44 TSHR HRAS
10
Show member pathways
11.42 NRAS HRAS
11 11.41 NRAS HRAS
12 11.37 NRAS HRAS
13 11.34 NRAS HRAS
14
Show member pathways
11.25 RET NRAS HRAS
15 11.21 NRAS HRAS
16 11.13 RET HRAS
17 11.13 RET HRAS
18 11.06 NRAS HRAS
19 11.05 NRAS HRAS
20 11 NRAS HRAS
21 10.99 NRAS HRAS
22 10.97 RET NRAS HRAS
23
Show member pathways
10.96 NRAS HRAS
24
Show member pathways
10.89 NRAS HRAS
25 10.82 NRAS HRAS
26 10.78 NRAS HRAS
27 10.71 NRAS HRAS
28 10.48 RET NRAS HRAS
29 10.44 NRAS HRAS
30 10.04 RET HRAS
31 10.03 TSHR TG

GO Terms for Benign Struma Ovarii

Biological processes related to Benign Struma Ovarii according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Ras protein signal transduction GO:0007265 9.26 NRAS HRAS
2 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.16 NRAS HRAS
3 MAPK cascade GO:0000165 9.13 RET NRAS HRAS
4 signal transduction GO:0007165 9.02 TSHR TG RET NRAS HRAS

Molecular functions related to Benign Struma Ovarii according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleotide binding GO:0000166 8.8 RET NRAS HRAS

Sources for Benign Struma Ovarii

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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