MCID: BNG029
MIFTS: 34

Benign Struma Ovarii

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Benign Struma Ovarii

MalaCards integrated aliases for Benign Struma Ovarii:

Name: Benign Struma Ovarii 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5209
NCIt 49 C40012
UMLS 71 C1511104

Summaries for Benign Struma Ovarii

Disease Ontology : 12 A struma ovarii that is not cancerous.

MalaCards based summary : Benign Struma Ovarii is related to ovarian germ cell teratoma and struma ovarii. An important gene associated with Benign Struma Ovarii is TG (Thyroglobulin), and among its related pathways/superpathways are Aldosterone synthesis and secretion and MAPK signaling pathway. Affiliated tissues include thyroid, skin and cervix, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Benign Struma Ovarii

Diseases in the Struma Ovarii family:

Malignant Struma Ovarii Benign Struma Ovarii

Diseases related to Benign Struma Ovarii via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 141)
# Related Disease Score Top Affiliating Genes
1 ovarian germ cell teratoma 30.5 TG RET NKX2-1 NCOA4 KRT19
2 struma ovarii 30.2 TSHR TG RET NKX2-1 NCOA4 KRT19
3 malignant struma ovarii 30.1 TG RET NKX2-1 NCOA4 KRT19
4 thyroid gland papillary carcinoma 29.4 TG RET PTCH1 PAX8 NKX2-1 NCOA4
5 thyroid carcinoma 29.0 TSHR TG RET NTRK1 NRAS NKX2-1
6 multicentric papillary thyroid carcinoma 10.5 TG RET
7 nonencapsulated sclerosing carcinoma 10.5 TG RET
8 teratoma 10.5
9 fetal adenoma 10.5 TG NRAS
10 iodine hypothyroidism 10.5 TSHR TG
11 multiple mucosal neuroma 10.5 RET NTRK1
12 selection of therapeutic option in melanoma 10.5 NRAS BRAF
13 selection of therapeutic option in colorectal cancer 10.5 NRAS BRAF
14 postsurgical hypothyroidism 10.5 TSHR TG
15 thyroid crisis 10.5 TSHR TG
16 melphalan allergy 10.5 NRAS BRAF
17 toxic diffuse goiter 10.4 TSHR TG
18 melanoma in congenital melanocytic nevus 10.4 NRAS BRAF
19 teratoma, ovarian 10.4
20 neonatal thyrotoxicosis 10.4 TSHR TG
21 renal pelvis adenocarcinoma 10.4 PAX8 KRT19
22 malignant anus melanoma 10.4 NRAS HRAS
23 syringocystadenoma papilliferum 10.4 KRT19 BRAF
24 acneiform dermatitis 10.4 NRAS HRAS
25 spitzoid melanoma 10.4 HRAS BRAF
26 graves' disease 10.4
27 hyperthyroidism 10.4
28 carotid body cancer 10.3 TG NKX2-1
29 central nervous system melanocytic neoplasm 10.3 NRAS HRAS
30 testicular spermatocytic seminoma 10.3 RET HRAS
31 malignant dermis tumor 10.3 NRAS HRAS
32 malignant skin fibrous histiocytoma 10.3 NRAS HRAS
33 spitz nevus 10.3 HRAS BRAF
34 ectopic thymus 10.3 TG NKX2-1
35 atypical follicular adenoma 10.3 TG RET PAX8
36 vulvar melanoma 10.3 NRAS HRAS
37 subacute lymphocytic thyroiditis 10.3 TSHR TG
38 thymus basaloid carcinoma 10.3 PAX8 NKX2-1
39 rete testis neoplasm 10.3 PAX8 NKX2-1
40 rete testis adenocarcinoma 10.3 PAX8 NKX2-1
41 renal adenoma 10.3 PAX8 KRT19
42 schimmelpenning-feuerstein-mims syndrome 10.3 NRAS HRAS
43 biliary tract benign neoplasm 10.3 KRT19 HRAS
44 thyroid malformation 10.3 PAX8 NKX2-1
45 endemic goiter 10.3 TSHR TG
46 respiratory distress syndrome in premature infants 10.3 NKX2-1 BRAF
47 wolffian duct adenocarcinoma 10.3 PAX8 HRAS
48 micronodular basal cell carcinoma 10.2 PTCH1 NRAS
49 chromosome 14q11-q22 deletion syndrome 10.2 NKX2-1 HRAS
50 ovarian germ cell cancer 10.2 TG NKX2-1 NCOA4

Graphical network of the top 20 diseases related to Benign Struma Ovarii:



Diseases related to Benign Struma Ovarii

Symptoms & Phenotypes for Benign Struma Ovarii

GenomeRNAi Phenotypes related to Benign Struma Ovarii according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.6 BRAF
2 Decreased viability GR00173-A 9.6 MAPK8IP1
3 Decreased viability GR00221-A-1 9.6 RET
4 Decreased viability GR00221-A-2 9.6 RET
5 Decreased viability GR00221-A-3 9.6 NTRK1
6 Decreased viability GR00221-A-4 9.6 BRAF MAPK8IP1 RET
7 Decreased viability GR00231-A 9.6 RET
8 Decreased viability GR00301-A 9.6 BRAF MAPK8IP1 NTRK1 RET
9 Decreased viability GR00342-S-3 9.6 MAPK8IP1
10 Decreased viability GR00381-A-1 9.6 BRAF
11 Decreased viability GR00402-S-2 9.6 BRAF MAPK8IP1 NTRK1 RET

MGI Mouse Phenotypes related to Benign Struma Ovarii:

45 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.39 AMH BRAF HRAS INSM1 KRT19 MAPK8IP1
2 homeostasis/metabolism MP:0005376 10.35 AMH BRAF HRAS INSM1 MAPK8IP1 MAPK8IP2
3 behavior/neurological MP:0005386 10.34 BRAF HRAS MAPK8IP1 MAPK8IP2 NKX2-1 NRAS
4 growth/size/body region MP:0005378 10.34 BRAF HRAS INSM1 KRT19 MAPK8IP1 MAPK8IP2
5 cellular MP:0005384 10.29 BRAF INSM1 KRT19 MAPK8IP1 NCOA4 NKX2-1
6 mortality/aging MP:0010768 10.25 BRAF HRAS INSM1 KRT19 MAPK8IP1 MAPK8IP2
7 digestive/alimentary MP:0005381 10.18 BRAF HRAS INSM1 KRT19 NKX2-1 NRAS
8 nervous system MP:0003631 10.18 BRAF HRAS INSM1 KRT19 MAPK8IP1 MAPK8IP2
9 craniofacial MP:0005382 10.08 BRAF HRAS INSM1 KRT19 NRAS PAX8
10 limbs/digits/tail MP:0005371 10.06 BRAF NRAS NTRK1 PAX8 PTCH1 RET
11 neoplasm MP:0002006 10.06 AMH BRAF HRAS KRT19 NKX2-1 NRAS
12 no phenotypic analysis MP:0003012 10.06 AMH HRAS INSM1 KRT19 MAPK8IP2 NKX2-1
13 normal MP:0002873 9.91 BRAF HRAS KRT19 NKX2-1 NRAS NTRK1
14 reproductive system MP:0005389 9.85 AMH BRAF KRT19 MAPK8IP1 MAPK8IP2 NKX2-1
15 respiratory system MP:0005388 9.5 BRAF HRAS INSM1 KRT19 NKX2-1 PTCH1
16 skeleton MP:0005390 9.28 BRAF HRAS KRT19 NKX2-1 NRAS PAX8

Drugs & Therapeutics for Benign Struma Ovarii

Search Clinical Trials , NIH Clinical Center for Benign Struma Ovarii

Genetic Tests for Benign Struma Ovarii

Anatomical Context for Benign Struma Ovarii

MalaCards organs/tissues related to Benign Struma Ovarii:

40
Thyroid, Skin, Cervix, Thymus, Ovary, Lung, Uterus

Publications for Benign Struma Ovarii

Articles related to Benign Struma Ovarii:

(show all 33)
# Title Authors PMID Year
1
Struma Ovarii: A Report of Three Cases and Literature Review. 61
30692823 2018
2
Struma ovarii - ultrasound features of a rare tumor mimicking ovarian cancer. 61
30167590 2018
3
Struma Ovarii With Hyperthyroidism. 61
28394842 2017
4
Level of HE4 is Correlated with Diagnosis of Struma Ovarii: A Case Report. 61
27381498 2016
5
[Benign struma ovarii: Report of 7 cases and review of the literature]. 61
26997461 2016
6
Metastatic malignant struma ovarii with coexistence of Hashimoto's thyroiditis. 61
27224256 2016
7
Sonographic and Pathologic Features of Struma Ovarii. 61
26149143 2015
8
Coexistence of benign struma ovarii, pseudo-Meigs' syndrome and elevated serum CA 125: Case report and review of the literature. 61
25789033 2015
9
Struma ovarii complicating pregnancy: a case report. 61
26411234 2015
10
Struma ovarii: management and follow-up of a rare ovarian tumour. 61
25640097 2015
11
Coexistence of radioactive iodine-resistant benign struma ovarii with cervical primary papillary cancer of the thyroid: an unusual cause of thyroglobulin-positive radioactive iodine-negative whole-body scans. 61
24934079 2014
12
[Clinical study on 68 cases with struma ovarii]. 61
25169639 2014
13
Coexistence of Graves' disease, papillary thyroid carcinoma and unilateral benign struma ovarii: case report and review of the literature. 61
23806737 2013
14
Struma ovarii and the thyroid surgeon. 61
22624934 2012
15
Unilateral malignant struma ovarii in a case of bilateral ovarian teratoma with raised CA-125 level: a rare case with treatment dilemmas. 61
21934226 2011
16
Struma ovarii in breast cancer. 61
21505904 2011
17
Coexistence of struma ovarii with marked ascites and elevated CA-125 levels: case report and literature review. 61
18807056 2009
18
Bilateral benign non functional struma ovarii with Pseudo-Meigs' syndrome. 61
19136795 2009
19
Clinical characteristics of struma ovarii. 61
19471561 2008
20
Cystic struma ovarii presenting as pseudo-Meigs' syndrome with elevated CA125 levels. A case report and review of the literature. 61
18334015 2008
21
[Cystic struma ovarii, a rare form of ovarian tumor--case report, and review of the literature]. 61
18039620 2007
22
BRAF in papillary thyroid carcinoma of ovary (struma ovarii). 61
17721188 2007
23
Benign struma ovarii in a patient with invasive papillary thyroid cancer: detection with I-131 SPECT-CT. 61
17452868 2007
24
Incidental diagnosis of struma ovarii after thyroidectomy for thyroid cancer: functional imaging studies and follow-up. 61
16516952 2006
25
Struma ovarii showing clinical characteristics of ovarian malignancy. 61
16343201 2005
26
Coexistence of Graves' disease and benign struma ovarii in a patient with marked ascites and elevated CA-125 levels. 61
16370564 2005
27
Scintigraphic detection of benign struma ovarii in a hyperthyroid patient. 61
15917485 2005
28
Pseudo-Meigs syndrome and elevated CA125 associated with struma ovarii. 61
15790478 2005
29
Benign struma ovarii complicating pregnancy: a case report and review of the literature. 61
12937924 2003
30
An unusual presentation of struma ovarii mimicking a malignant process. 61
12423825 2002
31
Metastatic thyroid carcinoma in the presence of struma ovarii. 61
11700816 2001
32
Struma ovarii. 61
7901063 1993
33
Limitations of CA125 in the preoperative evaluation of a pelvic mass: struma ovarii and ascites. 61
8216132 1993

Variations for Benign Struma Ovarii

Expression for Benign Struma Ovarii

Search GEO for disease gene expression data for Benign Struma Ovarii.

Pathways for Benign Struma Ovarii

Pathways related to Benign Struma Ovarii according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.68 TSHR TG PAX8 NRAS HRAS BRAF
2 12.51 NTRK1 NRAS MAPK8IP2 MAPK8IP1 HRAS BRAF
3
Show member pathways
12.25 RET PAX8 NTRK1 NRAS NCOA4 HRAS
4 12.2 TSHR PTCH1 BRAF AMH
5 12.16 PTCH1 NRAS HRAS BRAF
6
Show member pathways
12.08 NTRK1 NRAS HRAS BRAF
7
Show member pathways
11.96 NTRK1 NRAS HRAS BRAF
8 11.95 RET PTCH1 PAX8 NTRK1 NRAS NCOA4
9 11.85 NRAS HRAS BRAF
10 11.84 NRAS HRAS BRAF
11 11.83 NRAS HRAS BRAF
12 11.62 NRAS HRAS BRAF
13 11.59 NTRK1 NRAS HRAS BRAF
14
Show member pathways
11.55 NRAS HRAS BRAF
15
Show member pathways
11.54 RET NRAS HRAS BRAF
16 11.49 NRAS HRAS BRAF
17 11.4 RET NTRK1 NRAS HRAS
18 11.37 RET NRAS HRAS
19 11.3 NRAS HRAS BRAF
20 11.29 TSHR PAX8 HRAS BRAF
21 11.21 NRAS HRAS BRAF
22 11.1 NRAS HRAS BRAF
23 10.7 NRAS HRAS
24 10.3 TSHR TG

GO Terms for Benign Struma Ovarii

Cellular components related to Benign Struma Ovarii according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendritic growth cone GO:0044294 8.62 PTCH1 MAPK8IP1

Biological processes related to Benign Struma Ovarii according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.92 TSHR TG RET PTCH1 NRAS MAPK8IP1
2 cell differentiation GO:0030154 9.88 PAX8 NTRK1 NKX2-1 INSM1 BRAF AMH
3 positive regulation of transcription, DNA-templated GO:0045893 9.85 RET PTCH1 PAX8 NKX2-1 NCOA4
4 response to drug GO:0042493 9.73 RET PTCH1 NTRK1 AMH
5 positive regulation of MAPK cascade GO:0043410 9.67 RET NTRK1 HRAS
6 MAPK cascade GO:0000165 9.67 RET NRAS HRAS BRAF
7 positive regulation of gene expression GO:0010628 9.65 RET NKX2-1 HRAS BRAF AMH
8 urogenital system development GO:0001655 9.48 PAX8 AMH
9 animal organ morphogenesis GO:0009887 9.46 PTCH1 NKX2-1 HRAS BRAF
10 thyroid-stimulating hormone signaling pathway GO:0038194 8.96 TSHR PAX8
11 thyroid gland development GO:0030878 8.92 TG PAX8 NKX2-1 BRAF

Molecular functions related to Benign Struma Ovarii according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleotide binding GO:0000166 9.55 RET NTRK1 NRAS HRAS BRAF
2 protein-containing complex binding GO:0044877 9.35 TSHR PTCH1 NRAS MAPK8IP2 KRT19
3 mitogen-activated protein kinase kinase binding GO:0031434 9.32 MAPK8IP1 BRAF
4 MAP-kinase scaffold activity GO:0005078 9.26 MAPK8IP2 MAPK8IP1
5 thyroid-stimulating hormone receptor activity GO:0004996 8.62 TSHR PAX8

Sources for Benign Struma Ovarii

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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