MCID: BNG029
MIFTS: 32

Benign Struma Ovarii

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Benign Struma Ovarii

MalaCards integrated aliases for Benign Struma Ovarii:

Name: Benign Struma Ovarii 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5209
NCIt 50 C40012
UMLS 73 C1511104

Summaries for Benign Struma Ovarii

Disease Ontology : 12 A struma ovarii that is not cancerous.

MalaCards based summary : Benign Struma Ovarii is related to struma ovarii and thyroid cancer. An important gene associated with Benign Struma Ovarii is TSHR (Thyroid Stimulating Hormone Receptor), and among its related pathways/superpathways are GDNF-Family Ligands and Receptor Interactions and Bladder cancer. Affiliated tissues include thyroid, lung and skin, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Benign Struma Ovarii

Diseases in the Struma Ovarii family:

Malignant Struma Ovarii Benign Struma Ovarii

Diseases related to Benign Struma Ovarii via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 struma ovarii 30.8 RET TG TSHR
2 thyroid cancer 29.4 HRAS NRAS RET TG TSHR
3 graves' disease 10.3
4 thyroid cancer, nonmedullary, 1 10.2
5 pseudo-meigs syndrome 10.2
6 goiter 10.1 TG TSHR
7 neonatal hypothyroidism 10.1 TG TSHR
8 athyreosis 10.1 TG TSHR
9 endemic goiter 10.1 TG TSHR
10 postsurgical hypothyroidism 10.1 TG TSHR
11 hypothyroidism, congenital, nongoitrous, 2 10.1 TG TSHR
12 graves disease 1 10.1 TG TSHR
13 nontoxic goiter 10.1 TG TSHR
14 myxedema 10.1 TG TSHR
15 toxic diffuse goiter 10.1 TG TSHR
16 subacute thyroiditis 10.1 TG TSHR
17 papillary thyroid microcarcinoma 10.1 TG TSHR
18 colloid adenoma 10.1 SMUG1 TG
19 exophthalmos 10.1 TG TSHR
20 mature teratoma 10.1 SMUG1 TG
21 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.1 TG TSHR
22 autoimmune disease of endocrine system 10.1 TG TSHR
23 pulmonary aspergilloma 10.1 SMUG1 TG
24 ovarian germ cell cancer 10.1 RET TG
25 ectopic cushing syndrome 10.0 RET SMUG1
26 immune system disease 10.0 TG TSHR
27 giant congenital nevus 10.0 HRAS NRAS
28 schimmelpenning-feuerstein-mims syndrome 10.0 HRAS NRAS
29 ovarian melanoma 10.0 HRAS NRAS
30 malignant conjunctival melanoma 10.0 HRAS NRAS
31 melanomatosis 10.0 HRAS NRAS
32 marcus gunn phenomenon 10.0 HRAS NRAS
33 nodular malignant melanoma 10.0 HRAS NRAS
34 secondary hypertrophic osteoarthropathy 9.9 HRAS SMUG1
35 prostate squamous cell carcinoma 9.9 HRAS SMUG1
36 myelodysplastic myeloproliferative cancer 9.9 HRAS NRAS
37 meningeal melanomatosis 9.9 HRAS NRAS
38 melanocytic nevus syndrome, congenital 9.9 HRAS NRAS
39 acneiform dermatitis 9.9 HRAS NRAS
40 cowden disease 9.9 RET TG
41 vulvar melanoma 9.9 HRAS NRAS
42 core binding factor acute myeloid leukemia 9.9 HRAS NRAS
43 liver angiosarcoma 9.9 HRAS NRAS
44 cecum adenocarcinoma 9.9 HRAS SMUG1
45 nodular goiter 9.9 RET TG TSHR
46 follicular adenoma 9.9 RET TG TSHR
47 thyroiditis 9.9 RET TG TSHR
48 papillary carcinoma 9.9 RET TG TSHR
49 cell type benign neoplasm 9.9 HRAS TG
50 hashimoto thyroiditis 9.9 RET TG TSHR

Graphical network of the top 20 diseases related to Benign Struma Ovarii:



Diseases related to Benign Struma Ovarii

Symptoms & Phenotypes for Benign Struma Ovarii

GenomeRNAi Phenotypes related to Benign Struma Ovarii according to GeneCards Suite gene sharing:

26 (show all 18)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.73 NRAS
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-160 9.73 RET
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.73 NRAS
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.73 RET
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-28 9.73 HRAS NRAS RET
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.73 RET
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.73 HRAS
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.73 NRAS
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.73 HRAS
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 9.73 HRAS
11 Decreased viability GR00055-A-2 9.47 HRAS
12 Decreased viability GR00221-A-1 9.47 HRAS NRAS RET
13 Decreased viability GR00221-A-2 9.47 HRAS RET
14 Decreased viability GR00221-A-3 9.47 HRAS NRAS
15 Decreased viability GR00221-A-4 9.47 RET
16 Decreased viability GR00231-A 9.47 RET
17 Decreased viability GR00301-A 9.47 RET
18 Decreased viability GR00402-S-2 9.47 HRAS NRAS RET

MGI Mouse Phenotypes related to Benign Struma Ovarii:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.65 HRAS NRAS RET TG TSHR
2 homeostasis/metabolism MP:0005376 9.63 HRAS NRAS RET SMUG1 TG TSHR
3 digestive/alimentary MP:0005381 9.62 HRAS NRAS RET TG
4 limbs/digits/tail MP:0005371 9.26 NRAS RET TG TSHR
5 neoplasm MP:0002006 9.02 HRAS NRAS RET SMUG1 TSHR

Drugs & Therapeutics for Benign Struma Ovarii

Search Clinical Trials , NIH Clinical Center for Benign Struma Ovarii

Genetic Tests for Benign Struma Ovarii

Anatomical Context for Benign Struma Ovarii

MalaCards organs/tissues related to Benign Struma Ovarii:

41
Thyroid, Lung, Skin, Liver, Colon, T Cells, Myeloid

Publications for Benign Struma Ovarii

Articles related to Benign Struma Ovarii:

# Title Authors Year
1
Coexistence of benign struma ovarii, pseudo-Meigs' syndrome and elevated serum CA 125: Case report and review of the literature. ( 25789033 )
2015
2
Coexistence of radioactive iodine-resistant benign struma ovarii with cervical primary papillary cancer of the thyroid: an unusual cause of thyroglobulin-positive radioactive iodine-negative whole-body scans. ( 24934079 )
2014
3
Coexistence of Graves' disease, papillary thyroid carcinoma and unilateral benign struma ovarii: case report and review of the literature. ( 23806737 )
2013
4
Benign struma ovarii in a patient with invasive papillary thyroid cancer: detection with I-131 SPECT-CT. ( 17452868 )
2007
5
Coexistence of Graves' disease and benign struma ovarii in a patient with marked ascites and elevated CA-125 levels. ( 16370564 )
2005
6
Scintigraphic detection of benign struma ovarii in a hyperthyroid patient. ( 15917485 )
2005
7
Benign struma ovarii complicating pregnancy: a case report and review of the literature. ( 12937924 )
2003

Variations for Benign Struma Ovarii

Expression for Benign Struma Ovarii

Search GEO for disease gene expression data for Benign Struma Ovarii.

Pathways for Benign Struma Ovarii

Pathways related to Benign Struma Ovarii according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.77 HRAS NRAS RET
2 11.48 HRAS NRAS
3 11.44 HRAS TSHR
4 11.42 HRAS NRAS
5
Show member pathways
11.41 HRAS NRAS
6 11.37 HRAS NRAS
7 11.34 HRAS NRAS
8
Show member pathways
11.25 HRAS NRAS RET
9 11.2 HRAS NRAS
10 11.14 HRAS RET
11 11.13 HRAS RET
12 11.07 HRAS NRAS
13 11 HRAS NRAS
14 10.99 HRAS NRAS
15
Show member pathways
10.96 HRAS NRAS
16 10.94 HRAS NRAS RET
17
Show member pathways
10.89 HRAS NRAS
18 10.82 HRAS NRAS
19 10.78 HRAS NRAS
20 10.71 HRAS NRAS
21 10.48 HRAS NRAS RET
22 10.44 HRAS NRAS
23 10.03 HRAS RET
24 10.03 TG TSHR

GO Terms for Benign Struma Ovarii

Biological processes related to Benign Struma Ovarii according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Ras protein signal transduction GO:0007265 9.26 HRAS NRAS
2 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.16 HRAS NRAS
3 MAPK cascade GO:0000165 9.13 HRAS NRAS RET
4 signal transduction GO:0007165 9.02 HRAS NRAS RET TG TSHR

Molecular functions related to Benign Struma Ovarii according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleotide binding GO:0000166 8.8 HRAS NRAS RET

Sources for Benign Struma Ovarii

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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