MCID: BNG093
MIFTS: 42

Benign Teratoma

Categories: Cancer diseases, Fetal diseases

Aliases & Classifications for Benign Teratoma

MalaCards integrated aliases for Benign Teratoma:

Name: Benign Teratoma 12
Dermoid Cyst 12 54 43 15 17
Cystic Dermoid Choristoma 12
Mature Cystic Teratoma 12
Dermoid Choristoma 12
Teratoma, Benign 12
Dermoid Tumour 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0080602 DOID:2658
MeSH 43 D003884
NCIt 49 C67107 C9011
SNOMED-CT 67 72277008
ICD10 32 K09.8
UMLS 71 C0011649

Summaries for Benign Teratoma

Disease Ontology : 12 A cystic teratoma that is composed exclusively of mature tissues derived from two or three germ layers (ectoderm, mesoderm and endoderm).

MalaCards based summary : Benign Teratoma, also known as dermoid cyst, is related to dermoid cyst of ovary and adult teratoma. An important gene associated with Benign Teratoma is MIR520D (MicroRNA 520d), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Wnt / Hedgehog / Notch. The drugs Palbociclib and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include ovary, thyroid and testis, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Benign Teratoma

Diseases in the Teratoma family:

Benign Teratoma Malignant Teratoma
Adult Teratoma Intermediate Malignant Teratoma

Diseases related to Benign Teratoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 836)
# Related Disease Score Top Affiliating Genes
1 dermoid cyst of ovary 34.7 CALB2 AMH AFP
2 adult teratoma 32.6 CEACAM5 AFP
3 cystic teratoma 31.3 SYP NKX2-1 MIR520D KRT7 KRT20 ENO2
4 mature teratoma 31.2 SYP SALL4 POU5F1 NANOG KRT7 CEACAM5
5 pseudomyxoma peritonei 31.0 KRT7 KRT20 CEACAM5 CDX2
6 obstructive hydrocephalus 31.0 SYP ENO2 AFP
7 ovarian mucinous neoplasm 30.7 KRT7 KRT20 CEACAM5 CDX2
8 mucinous cystadenocarcinoma 30.6 KRT7 KRT20 CEACAM5
9 cystadenocarcinoma 30.6 NANOG KRT7 CEACAM5
10 carcinoid syndrome 30.5 SYP ENO2
11 signet ring cell adenocarcinoma 30.5 KRT7 KRT20 CEACAM5 CDX2
12 adenocarcinoma in situ 30.5 KRT7 KRT20 CEACAM5 CDX2
13 ovarian mucinous adenocarcinoma 30.5 KRT7 KRT20 CDX2
14 intestinal obstruction 30.5 KRT7 KRT20 CEACAM5 CDX2
15 ovarian brenner tumor 30.5 KRT7 KRT20
16 basal cell carcinoma 30.5 SYP PTCH1 KRT7 KRT20 CEACAM5
17 fibroma 30.4 PTCH1 KRT7 CALB2
18 leydig cell tumor 30.4 SYP CALB2 AFP
19 paget disease, extramammary 30.4 KRT7 KRT20 CEACAM5
20 granulosa cell tumor of the ovary 30.4 SYP KRT7 ENO2
21 testicular disease 30.3 CALB2 AMH AFP
22 endocervical adenocarcinoma 30.3 KRT7 KRT20 CEACAM5 CDX2
23 meibomian cyst 30.3 KRT20 CLEC2A
24 sacrococcygeal teratoma 30.3 MNX1 AFP
25 angiomyoma 30.2 ENO2 CLEC2A
26 papilloma of choroid plexus 30.2 SYP KRT7 ENO2
27 hidradenoma 30.2 KRT7 CLEC2A CEACAM5
28 cystadenoma 30.2 SYP KRT7 KRT20 CEACAM5 CALB2 AFP
29 ovary adenocarcinoma 30.2 KRT7 KRT20 CEACAM5 CDX2 CALB2
30 paraganglioma 30.2 TG SYP ENO2
31 appendix adenocarcinoma 30.1 SYP KRT7 KRT20 CEACAM5 CDX2
32 hemangioma 30.1 SYP NKX2-1 KRT7 ENO2
33 mucoepidermoid carcinoma 30.0 TG NKX2-1 KRT7 CEACAM5
34 thyroid gland papillary carcinoma 30.0 TG PTCH1 NKX2-1
35 mature teratoma of the ovary 30.0 TG SYP ENO2 AFP
36 pleomorphic carcinoma 30.0 NKX2-1 KRT7 CALB2
37 ovarian serous cystadenocarcinoma 30.0 SYP NANOG CEACAM5 CALB2
38 ovarian benign neoplasm 30.0 KRT7 KRT20 CEACAM5 CALB2 AFP
39 cervical adenocarcinoma 29.9 KRT7 KRT20 CEACAM5 CDX2 CALB2
40 adenosquamous carcinoma 29.9 SYP NKX2-1 KRT7 CEACAM5
41 adenocarcinoma 29.9 NKX2-1 KRT7 KRT20 CEACAM5 CDX2
42 ovarian cystic teratoma 29.9 SYP NKX2-1 AFP
43 polycystic liver disease 1 with or without kidney cysts 29.9 PTCH1 KRT7 KRT20 CEACAM5 CALB2
44 adenomatoid tumor 29.8 NKX2-1 KRT7 CALB2 AFP
45 sweat gland cancer 29.8 SYP KRT7 KRT20 CLEC2A CEACAM5
46 neuroendocrine tumor 29.8 SYP NKX2-1 KRT20 ENO2 CDX2
47 endodermal sinus tumor 29.8 SALL4 POU5F1 NANOG AFP
48 carcinoid tumors, intestinal 29.8 SYP NKX2-1 ENO2
49 sertoli-leydig cell tumor 29.7 SYP KRT7 ENO2 CALB2 AFP
50 omphalocele 29.7 MNX1 CALB2 AFP

Graphical network of the top 20 diseases related to Benign Teratoma:



Diseases related to Benign Teratoma

Symptoms & Phenotypes for Benign Teratoma

GenomeRNAi Phenotypes related to Benign Teratoma according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.47 AFP
2 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.47 AFP
3 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.47 POU5F1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.47 POU5F1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.47 KRT7
6 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.47 POU5F1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.47 AFP KRT7 POU5F1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.47 AFP
9 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.47 POU5F1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.47 AFP
11 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.47 KRT7 POU5F1

MGI Mouse Phenotypes related to Benign Teratoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.9 AFP CALB2 CYS1 ENO2 MNX1 NKX2-1
2 digestive/alimentary MP:0005381 9.56 CDX2 CYS1 MNX1 NKX2-1 POU5F1 PTCH1
3 endocrine/exocrine gland MP:0005379 9.28 AFP AMH CDX2 CYS1 MNX1 NKX2-1

Drugs & Therapeutics for Benign Teratoma

Drugs for Benign Teratoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Palbociclib Approved, Investigational Phase 2 571190-30-2 11431660 5005498 5330286
2
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
3 Cyclin-Dependent Kinase Inhibitor Proteins Phase 2
4 Protein Kinase Inhibitors Phase 2
5
Hyaluronic acid Approved, Vet_approved 9004-61-9 53477741
6 Anesthetics
7 Central Nervous System Depressants
8 Adjuvants, Immunologic
9 Protective Agents
10 Immunologic Factors
11 Viscosupplements
12 Carboxymethylcellulose Sodium

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Single-Port Compared With Conventional Laparoscopic Cystectomy for Ovarian Dermoid Cysts Completed NCT02009228 Phase 3
2 Phase II Trial of the Cyclin-Dependent Kinase Inhibitor PD 0332991 in Patients With Cancer Recruiting NCT01037790 Phase 2 PD-0332991
3 Epidural and Spinal Anesthesia Techniques in Pilonidal Dermoid Sinus Surgeries: Prospective Randomized Trials Unknown status NCT02580500
4 Mesial Incision for Laparoscopic Dermoid Cystectomy: a New Safe and Fertility-sparing Technique Completed NCT01590030
5 A Non-randomized Controlled Clinical Trial of Corneal Epithelial Autograft for Limbal Dermoid Recruiting NCT03217461
6 The Assessment of the Use of Anti-Adhesion Agents to Prevent Pelvic Postoperative Adhesions Recruiting NCT04063085
7 Systematic Proposal of Fertility Preservation by Oocyte Freezing in Case of Benign Ovarian Tumors With High Risk of Recurrence Not yet recruiting NCT03823833

Search NIH Clinical Center for Benign Teratoma

Cochrane evidence based reviews: dermoid cyst

Genetic Tests for Benign Teratoma

Anatomical Context for Benign Teratoma

MalaCards organs/tissues related to Benign Teratoma:

40
Ovary, Thyroid, Testis, Lung, Tongue, Liver, Colon

Publications for Benign Teratoma

Articles related to Benign Teratoma:

(show top 50) (show all 2621)
# Title Authors PMID Year
1
Ovarian dermoid cyst-associated autoimmune hemolytic anemia: a case report with emphasis on pathogenic mechanisms. 54 61
8623764 1996
2
Atypical dermoid cyst of the ovary during pregnancy: A multi-modality diagnostic approach. 61
31956391 2020
3
Conservative treatment versus surgical excision of ovarian dermoid cysts: Impact on ovarian stimulation and IVF cycle success. 61
31828777 2020
4
Pediatric whole body MRI detects causative ovarian teratoma in opsoclonus myoclonus syndrome. 61
31890069 2020
5
Sellar surprises: a single-centre experience of unusual sellar masses. 61
31910151 2020
6
Midline Intranasal Dermoid Cyst With Intracranial Extension: Technical Details of a Multidisciplinary Approach to a Rare Condition. 61
31985595 2020
7
Patient with Epilepsy Caused by the Spontaneous Rupture of an Intracerebral Dermoid Cyst. 61
31954900 2020
8
Pressure ulcer following circumferential head dressing. 61
31997678 2020
9
Nonodontogenic Cysts. 61
31735234 2020
10
A Large Dermoid Cyst Causing Plagiocephaly. 61
31977706 2020
11
Nasal dermoid cysts with intracranial extension: avoiding coronal incision through midline exposure and nasal bone osteotomy. 61
31812133 2019
12
Intracranial growing teratoma syndrome observed at 44 months after initial treatment; a case presentation and literature review. 61
31853895 2019
13
Rare Case of Giant Supratentorial Dermoid Cyst. 61
31821914 2019
14
Lateral rectus dermoid cyst presenting as incomitant esotropia. 61
30691358 2019
15
A Case of Pseudo-Meigs Syndrome Caused by a Giant Uterine Leiomyoma with Cystic Degeneration. 61
31902853 2019
16
Diagnosis and Treatment of Scalp Arteriovenous Malformations With Intracranial Extension. 61
31403511 2019
17
Differentiation of sublingual thyroglossal duct cyst from midline dermoid cyst with diffusion weighted imaging. 61
31400658 2019
18
Caecal dermoid cyst presenting as an appendicular mucocele on abdominal imaging. 61
31516651 2019
19
Explosion of dermoid cyst into five intracranial spaces- a rare event. 61
31713448 2019
20
Subcutaneous dermoid cysts on the eyebrow and neck. 61
31414508 2019
21
Whole spine MRI is not required in investigating uncomplicated paediatric lumbosacral lipoma. A retrospective single-institution review. 61
31502036 2019
22
Nasal Congenital Panfollicular Nevus. 61
31763229 2019
23
Orbital and periorbital dermoid/epidermoid cyst: a series of 280 cases and a brief review. 61
31712044 2019
24
Pediatric congenital buttock sinus tract:10-year experience in a single institution. 61
31690282 2019
25
Unusual intrascrotal lesions in adults in urological practice. 61
31697257 2019
26
Pilomatrixoma: A Rare Cause of Midline Neck Swelling. 61
31659972 2019
27
[Clinical features and pathological analysis of lacrimal gland occupying lesions in 91 cases]. 61
31715681 2019
28
Ruptured dermoid cyst of the conus medullaris in the myelomeningocele sac revealed at the initial repair surgery. 61
31776717 2019
29
[Orbital Disorders in Childhood]. 61
31412385 2019
30
Ocular Adnexal Racemose Cysticercosis Masquerading as Dermoid Cyst. 61
30882589 2019
31
Spinal Intradural Extramedullary Dermoid Cyst. 61
31759148 2019
32
Generalised purulent peritonitis and small bowel obstruction due to a spontaneously perforated ovarian dermoid cyst. 61
31645380 2019
33
Fimbrial dermoid cyst with elevated CA19-9 levels: A case report. 61
31871902 2019
34
Huge ovarian mature cystic teratoma with gliomatosis peritonei and massive ascites in a postmenopausal woman. 61
31867262 2019
35
Abnormal arterial anatomy and an unexpected intracranial haemorrhage. 61
31666288 2019
36
Dermoid Cyst of the Parotid Gland: A Rare Entity. 61
31742069 2019
37
A rare case of benign teratoma of the facial fronto-temporal region in adult male. 61
31760398 2019
38
Giant Ocular Lipodermoid Cyst in Encephalocraniocutaneous Lipomatosis: Surgical Treatment and Genetic Analysis. 61
31649234 2019
39
[Congenital Dermal Sinus with Dermoid Cyst Complicated by Brain Abscess: A Case Report]. 61
31666425 2019
40
Clinical approach to the diagnosis and successful management of anti-NMDA receptor encephalitis when antibody testing is not possible. 61
31604715 2019
41
Anal duplication: is surgery indicated? A report of three cases and review of the literature. 61
31256296 2019
42
Does multiparametric US improve diagnostic accuracy in the characterization of small testicular masses? 61
31559180 2019
43
Proton MR spectroscopy and the detection of malignancy in ovarian masses. 61
31287729 2019
44
Minimally Invasive Endoscopic Aspiration of a Spinal Epidural Dermoid Cyst Extending From T10 to the Sacrum: 2-Dimensional Operative Video. 61
31504844 2019
45
Multilobular dermoid cyst of the orbit. 61
30215530 2019
46
Dermoid cyst simulating recurrent dacryocystitis in a toddler. 61
31358169 2019
47
[Treatment of benign tumors in thoracic spinal canal by modified replanting posterior ligament complex applying piezoelectric osteotomy]. 61
31407559 2019
48
Intratumoral Rathke's Cleft Cyst Remnants Within Craniopharyngioma, Pituitary Adenoma, Suprasellar Dermoid, and Epidermoid Cysts: A Ubiquitous Signature of Ectodermal Lineage or a Transitional Entity? 61
30010935 2019
49
Triple synchronous tumour of female genital tract: cervical squamous cell carcinoma, right ovarian dermoid cyst and left ovarian benign Brenner tumour. 61
31331931 2019
50
Frontotemporal Dermal Sinus Tract with 2 Connected Intradiploic Dermoid Cysts: A Rare Case and Review of the Literature. 61
30930322 2019

Variations for Benign Teratoma

Expression for Benign Teratoma

Search GEO for disease gene expression data for Benign Teratoma.

Pathways for Benign Teratoma

GO Terms for Benign Teratoma

Biological processes related to Benign Teratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pattern specification process GO:0007389 9.33 PTCH1 NKX2-1 CDX2
2 endodermal cell fate specification GO:0001714 8.96 POU5F1 NANOG
3 somatic stem cell population maintenance GO:0035019 8.92 SALL4 POU5F1 NANOG CDX2

Sources for Benign Teratoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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