MCID: BNG093
MIFTS: 37

Benign Teratoma

Categories: Cancer diseases, Fetal diseases

Aliases & Classifications for Benign Teratoma

MalaCards integrated aliases for Benign Teratoma:

Name: Benign Teratoma 12 15
Dermoid Cyst 12 54 43 15 17
Cystic Dermoid Choristoma 12
Mature Cystic Teratoma 12
Dermoid Choristoma 12
Teratoma, Benign 12
Dermoid Tumour 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0080602 DOID:2658
MeSH 43 D003884
NCIt 49 C67107 C9011
SNOMED-CT 67 123151001
ICD10 32 K09.8
UMLS 71 C0011649

Summaries for Benign Teratoma

Disease Ontology : 12 A cystic teratoma that is composed exclusively of mature tissues derived from two or three germ layers (ectoderm, mesoderm and endoderm).

MalaCards based summary : Benign Teratoma, also known as dermoid cyst, is related to dermoid cyst of ovary and mature teratoma. An important gene associated with Benign Teratoma is AFP (Alpha Fetoprotein). The drugs Cisplatin and Palbociclib have been mentioned in the context of this disorder. Affiliated tissues include ovary, tongue and bone, and related phenotype is endocrine/exocrine gland.

Related Diseases for Benign Teratoma

Diseases in the Teratoma family:

Benign Teratoma Malignant Teratoma
Adult Teratoma Intermediate Malignant Teratoma

Diseases related to Benign Teratoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 914)
# Related Disease Score Top Affiliating Genes
1 dermoid cyst of ovary 34.8 CALB2 AMH AFP
2 mature teratoma 31.9 TP53 TG SYP KRT7 ENO2 CEACAM5
3 adult teratoma 31.8 TP53 CHGA CEACAM5 AFP
4 cystic teratoma 31.6 TP53 SYP NKX2-1 KRT7 KRT20 ENO2
5 exophthalmos 31.3 TG SYP ENO2
6 obstructive hydrocephalus 31.1 SYP ENO2 AFP
7 struma ovarii 30.9 TG NKX2-1 KRT7
8 hydrocephalus 30.8 TP53 SYP PTCH1 ENO2
9 ovarian mucinous neoplasm 30.8 KRT7 KRT20 CEACAM5 CDX2
10 angiosarcoma 30.7 TP53 KRT7 CALB2
11 mucinous cystadenocarcinoma 30.7 KRT7 KRT20 CEACAM5
12 bile duct cysts 30.7 KRT7 CEACAM5 AFP
13 adenocarcinoma in situ 30.6 KRT7 KRT20 CEACAM5 CDX2
14 intestinal obstruction 30.6 KRT7 KRT20 CEACAM5 CDX2
15 endodermal sinus tumor 30.6 KRT7 CHGA CEACAM5 AFP
16 carcinoid syndrome 30.6 SYP ENO2 CHGA
17 cystadenocarcinoma 30.6 TP53 KRT7 CEACAM5
18 pseudomyxoma peritonei 30.6 TP53 KRT7 KRT20 CEACAM5 CDX2
19 ganglioneuroma 30.5 SYP ENO2 CHGA
20 paget disease, extramammary 30.5 KRT7 KRT20 CEACAM5
21 leydig cell tumor 30.5 SYP CALB2 AFP
22 carcinosarcoma 30.4 TP53 KRT7 CEACAM5 CALB2
23 fibroma 30.4 PTCH1 KRT7 CALB2
24 ovarian mucinous adenocarcinoma 30.4 KRT7 KRT20 CEACAM5 CDX2
25 lymphangioma 30.4 TP53 CEACAM5 CDX2
26 ovarian small cell carcinoma 30.4 SYP ENO2 CALB2
27 sacrococcygeal teratoma 30.4 MNX1 AFP
28 paraganglioma 30.4 TG SYP ENO2 CHGA
29 hidradenoma 30.4 KRT7 CLEC2A CEACAM5
30 ovarian cystadenoma 30.3 TP53 KRT7 CEACAM5
31 ovarian cystic teratoma 30.3 NKX2-1 AFP
32 angiomyoma 30.3 ENO2 CLEC2A
33 meibomian cyst 30.3 KRT7 KRT20 CLEC2A
34 adenomatoid tumor 30.3 NKX2-1 KRT7 CALB2 AFP
35 subependymoma 30.3 SYP ENO2 CHGA
36 adenofibroma 30.3 TP53 KRT7 CALB2
37 mature teratoma of the ovary 30.2 TG ENO2 CEACAM5 AFP
38 central neurocytoma 30.2 SYP ENO2 CHGA
39 ovarian brenner tumor 30.2 KRT7 KRT20 KRT13
40 dysgerminoma 30.2 KRT7 KRT20 ENO2 AFP
41 testicular disease 30.1 TP53 AMH AFP
42 central nervous system primitive neuroectodermal neoplasm 30.1 TP53 SYP ENO2
43 spinal cancer 30.1 TP53 SYP ENO2
44 malignant teratoma 30.1 SYP ENO2 CEACAM5 AFP
45 granular cell tumor 30.1 SYP NKX2-1 ENO2 CALB2
46 ovarian serous cystadenocarcinoma 30.0 TP53 SYP CEACAM5 CALB2
47 keratocystic odontogenic tumor 30.0 TP53 PTCH1 CALB2
48 basal cell carcinoma 30.0 TP53 SYP PTCH1 KRT7 KRT20 CEACAM5
49 transitional cell carcinoma 30.0 TP53 KRT7 KRT20 ENO2
50 ganglioneuroblastoma 29.9 TP53 SYP ENO2

Graphical network of the top 20 diseases related to Benign Teratoma:



Diseases related to Benign Teratoma

Symptoms & Phenotypes for Benign Teratoma

MGI Mouse Phenotypes related to Benign Teratoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.32 AFP AMH CDX2 CHGA CYS1 MNX1

Drugs & Therapeutics for Benign Teratoma

Drugs for Benign Teratoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
2
Palbociclib Approved, Investigational Phase 2 571190-30-2 5005498 11431660 5330286
3 Protein Kinase Inhibitors Phase 2
4 Cyclin-Dependent Kinase Inhibitor Proteins Phase 2
5
Hyaluronic acid Approved, Vet_approved 9004-61-9 53477741
6 Anesthetics
7 Carboxymethylcellulose Sodium

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Single-Port Compared With Conventional Laparoscopic Cystectomy for Ovarian Dermoid Cysts Completed NCT02009228 Phase 3
2 Phase II Trial of the Cyclin-Dependent Kinase Inhibitor PD 0332991 in Patients With Cancer Completed NCT01037790 Phase 2 PD-0332991
3 Epidural and Spinal Anesthesia Techniques in Pilonidal Dermoid Sinus Surgeries: Prospective Randomized Trials Unknown status NCT02580500
4 Mesial Incision for Laparoscopic Dermoid Cystectomy: a New Safe and Fertility-sparing Technique Completed NCT01590030
5 Immunohistochemical Evaluation of Protein P16 Expression in Ovarian Germ Cell Tumors. Recruiting NCT04283773
6 A Non-randomized Controlled Clinical Trial of Corneal Epithelial Autograft for Limbal Dermoid Recruiting NCT03217461
7 The Assessment of the Use of Anti-Adhesion Agents to Prevent Pelvic Postoperative Adhesions Recruiting NCT04063085
8 Systematic Proposal of Fertility Preservation by Oocyte Freezing in Case of Benign Ovarian Tumors With High Risk of Recurrence Not yet recruiting NCT03823833

Search NIH Clinical Center for Benign Teratoma

Cochrane evidence based reviews: dermoid cyst

Genetic Tests for Benign Teratoma

Anatomical Context for Benign Teratoma

MalaCards organs/tissues related to Benign Teratoma:

40
Ovary, Tongue, Bone, Testis, Brain, Thyroid, Pancreas

Publications for Benign Teratoma

Articles related to Benign Teratoma:

(show top 50) (show all 2649)
# Title Authors PMID Year
1
Ovarian dermoid cyst-associated autoimmune hemolytic anemia: a case report with emphasis on pathogenic mechanisms. 61 54
8623764 1996
2
The spectrum of orbital dermoid cysts and their surgical management. 61
31246146 2020
3
Ruptured ovarian dermoid cyst - an unusual cause for peritonitis in pregnancy: a case report. 61
32551131 2020
4
Ocular and Periocular Tumors in Asian Indian Children and Adolescents. 61
32221055 2020
5
Nasofrontal dermoid cyst: rare presentation of a philtrum sinus. 61
32201047 2020
6
Infected intradural dermoid cyst without dermal sinus tract mimicking brain abscess: A case report. 61
32535529 2020
7
Midline Intranasal Dermoid Cyst With Intracranial Extension: Technical Details of a Multidisciplinary Approach to a Rare Condition. 61
31985595 2020
8
Minimally Invasive Endoscopic Aspiration of a Spinal Epidural Dermoid Cyst Extending From T10 to the Sacrum: 2-Dimensional Operative Video. 61
31504844 2020
9
Mature Cervical Teratoma Extending Into the Anterior Mediastinum of an Adult. 61
32425061 2020
10
A Dermoid Cyst Presenting as a Hypoechoic Pancreatic Mass. 61
32453050 2020
11
Ruptured dermoid cyst in the Meckel's cave presenting with trigeminal neuralgia in a pediatric patient: a case report. 61
32361932 2020
12
Ruptured dermoid cyst of the conus medullaris in the myelomeningocele sac revealed at the initial repair surgery. 61
31776717 2020
13
Pseudo-Meigs Syndrome Caused by a Giant Uterine Leiomyoma with Cystic Degeneration: A Case Report. 61
31902853 2020
14
Gorlin syndrome-induced pluripotent stem cells form medulloblastoma with loss of heterozygosity in PTCH1. 61
32436863 2020
15
Ultrasound features of immature ovarian teratomas: Case series and review of literature. 61
32528544 2020
16
Dermoid Cyst in the Postauricular Area. 61
32487830 2020
17
Intraconal dermoid cyst - A common condition at uncommon location and age. 61
32317549 2020
18
Patient with Epilepsy Caused by the Spontaneous Rupture of an Intracerebral Dermoid Cyst. 61
31954900 2020
19
Intracranial growing teratoma syndrome observed at 44 months after initial treatment; a case presentation and literature review. 61
31853895 2020
20
Bilobed Dermoid Cyst in Unique Location. 61
32282645 2020
21
Orbital and periorbital dermoid/epidermoid cyst: a series of 280 cases and a brief review. 61
31712044 2020
22
Concomitant Congenital Intraoral Dermoid Cyst and Heterotopic Gastrointestinal Cyst. 61
32285307 2020
23
Endoscopic-Assisted Lateral Orbitotomy for Large Orbital Roof Dermoid Cysts With Dural Invasion. 61
32265376 2020
24
Conservative treatment versus surgical excision of ovarian dermoid cysts: Impact on ovarian stimulation and IVF cycle success. 61
31828777 2020
25
Effects of laparoscopic cystectomy on ovarian reserve in patients with endometrioma and dermoid cyst. 61
32341825 2020
26
Atypical dermoid cyst of the ovary during pregnancy: A multi-modality diagnostic approach. 61
31956391 2020
27
Emergency presentation of a dermoid cyst of the groin: a diagnostic confounder on the acute surgical take. 61
31060101 2020
28
Ovarian dermoid cyst presenting with unusual complaint of hair coming out of the anal orifice - A case report. 61
32207442 2020
29
Laparoscopic Port Site Dermoid Cyst: A Rare and Unusual Presentation. 61
32135245 2020
30
An Unusual Case of Unilateral Multiple Periorbital Dermoid Cyst. 61
32087872 2020
31
Pilosebaceous Malignant Transformation of Dermoid Cyst in the Orbit. 61
32118840 2020
32
Dermoid Cyst: Outcome Analysis in a Pediatric Referral Hospital. 61
32205776 2020
33
Dermoid cyst with secretion of CA 19-9 detected by 18F-FDG PET/CT: A case report. 61
32150047 2020
34
Pediatric whole body MRI detects causative ovarian teratoma in opsoclonus myoclonus syndrome. 61
31890069 2020
35
Rare Case of Giant Supratentorial Dermoid Cyst. 61
31821914 2020
36
A Large Dermoid Cyst Causing Plagiocephaly. 61
31977706 2020
37
Subconjunctival Lipid Leakage From Deep Orbital Dermoid Cysts. 61
32118842 2020
38
Spinal Intradural Extramedullary Dermoid Cyst. 61
31759148 2020
39
Malignant struma ovarii with a robust response to radioactive iodine. 61
32061155 2020
40
Unilateral akathisia and choreoathetosis as an unusual presentation of a frontal lobe dermoid cyst. 61
32098514 2020
41
Sellar surprises: a single-centre experience of unusual sellar masses. 61
31910151 2020
42
Spontaneously Ruptured Dermoid Cysts and Their Potential Complications: A Review of the Literature with a Case Report. 61
32292616 2020
43
What's up with my neck? Ultrasound and surgical findings in cervical midline tumors. 61
32166918 2020
44
Pressure ulcer following circumferential head dressing. 61
31997678 2020
45
Nonodontogenic Cysts. 61
31735234 2020
46
Nasal dermoid cysts with intracranial extension: avoiding coronal incision through midline exposure and nasal bone osteotomy. 61
31812133 2019
47
Lateral rectus dermoid cyst presenting as incomitant esotropia. 61
30691358 2019
48
Caecal dermoid cyst presenting as an appendicular mucocele on abdominal imaging. 61
31516651 2019
49
Explosion of dermoid cyst into five intracranial spaces- a rare event. 61
31713448 2019
50
Differentiation of sublingual thyroglossal duct cyst from midline dermoid cyst with diffusion weighted imaging. 61
31400658 2019

Variations for Benign Teratoma

Expression for Benign Teratoma

Search GEO for disease gene expression data for Benign Teratoma.

Pathways for Benign Teratoma

GO Terms for Benign Teratoma

Biological processes related to Benign Teratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pattern specification process GO:0007389 8.8 PTCH1 NKX2-1 CDX2

Sources for Benign Teratoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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