MCID: BRY001
MIFTS: 43

Berylliosis

Categories: Immune diseases, Respiratory diseases

Aliases & Classifications for Berylliosis

MalaCards integrated aliases for Berylliosis:

Name: Berylliosis 12 76 44 15
Beryllium Poisoning 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10322
ICD10 33 J63.2
MeSH 44 D001607
SNOMED-CT 68 8247009
UMLS 73 C0005138

Summaries for Berylliosis

Disease Ontology : 12 A pneumoconiosis that involves allergic response located in lungs caused by inhalation of beryllium compounds.

MalaCards based summary : Berylliosis, also known as beryllium poisoning, is related to beryllium disease and chronic beryllium disease. An important gene associated with Berylliosis is HLA-DPA1 (Major Histocompatibility Complex, Class II, DP Alpha 1), and among its related pathways/superpathways are Innate Immune System and IL-2 Pathway. The drugs Infliximab and Mesalamine have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and testes.

Wikipedia : 76 Berylliosis, or chronic beryllium disease (CBD), is a chronic allergic-type lung response and chronic... more...

Related Diseases for Berylliosis

Diseases related to Berylliosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
# Related Disease Score Top Affiliating Genes
1 beryllium disease 32.9 HLA-DRB1 HLA-DPB1 HLA-DPA1
2 chronic beryllium disease 32.8 IFNG HLA-DRB1 HLA-DPB1 HLA-DPA1
3 rheumatic fever 30.0 IL2 HLA-DRB1
4 silicosis 10.2
5 asbestosis 10.1
6 conjunctivitis 10.1 IL2 IFNG
7 variola major 10.1 IL2 IFNG
8 fixed drug eruption 10.1 IL2 IFNG
9 atopic keratoconjunctivitis 10.1 IL2 IFNG
10 keratoconjunctivitis 10.1 IL2 IFNG
11 mucinoses 10.1 POMC IFNG
12 pericardial tuberculosis 10.1 POMC IFNG
13 clonorchiasis 10.1 IL2 IFNG
14 crohn's colitis 10.1 IL2 IFNG
15 chronic active epstein-barr virus infection 10.1 IL2 IFNG
16 intermediate uveitis 10.1 IL2 IFNG
17 posterior uveitis 10.1 IL2 IFNG
18 coccidiosis 10.1 IL2 IFNG
19 erythema multiforme 10.1 IL2 IFNG
20 hematopoietic stem cell transplantation 10.1 IL2 IFNG
21 stevens-johnson syndrome/toxic epidermal necrolysis 10.1 IL2 IFNG
22 hypersensitivity reaction type iv disease 10.1 IL2 IFNG
23 autoimmune disease of endocrine system 10.1 IL2 IFNG
24 acute graft versus host disease 10.1 IL2 IFNG
25 lepromatous leprosy 10.1 IL2 IFNG
26 tuberculous empyema 10.1 POMC IL2
27 testicular disease 10.1 IL2 IFNG
28 paracoccidioidomycosis 10.1 IL2 IFNG
29 autoimmune uveitis 10.1 IL2 IFNG
30 pleurisy 10.1 IL2 IFNG
31 herpes zoster 10.1 IL2 IFNG
32 acute disseminated encephalomyelitis 10.1 HLA-DRB1 HLA-DPA1
33 brucellosis 10.1 IL2 IFNG
34 human immunodeficiency virus infectious disease 10.1 IL2 IFNG
35 eosinophilia-myalgia syndrome 10.1 IFNG HLA-DRB1
36 tropical spastic paraparesis 10.1 IL2 IFNG
37 central nervous system vasculitis 10.1 IFNG HLA-DRB1
38 smallpox 10.1 IL2 IFNG
39 idiopathic bronchiectasis 10.1 IFNG HLA-DRB1
40 tonsillitis 10.1 IL2 IFNG
41 chronic inflammatory demyelinating polyradiculoneuropathy 10.1 IFNG HLA-DRB1
42 polyradiculoneuropathy 10.1 IFNG HLA-DRB1
43 parasitic protozoa infectious disease 10.1 IL2 IFNG
44 histoplasmosis 10.1 IFNG HLA-DRB1
45 peanut allergy 10.1 IFNG HLA-DRB1
46 hemorrhagic fever 10.1 IFNG HLA-DRB1
47 filariasis 10.1 IL2 IFNG
48 pulmonary sarcoidosis 10.1 IL2 IFNG
49 primary bacterial infectious disease 10.1 IL2 IFNG
50 recurrent respiratory papillomatosis 10.1 IL2 HLA-DRB1

Graphical network of the top 20 diseases related to Berylliosis:



Diseases related to Berylliosis

Symptoms & Phenotypes for Berylliosis

Drugs & Therapeutics for Berylliosis

Drugs for Berylliosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved Phase 1, Phase 2 170277-31-3
2 Mesalamine Phase 1, Phase 2 89-57-6
3 Analgesics Phase 1, Phase 2
4 Peripheral Nervous System Agents Phase 1, Phase 2
5 Analgesics, Non-Narcotic Phase 1, Phase 2
6 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
7 Anti-Inflammatory Agents Phase 1, Phase 2
8 Antirheumatic Agents Phase 1, Phase 2,Phase 2
9 Dermatologic Agents Phase 1, Phase 2
10 Gastrointestinal Agents Phase 1, Phase 2
11
Heparin Approved, Investigational 9005-49-6 772 46507594
12 Pharmaceutical Solutions
13 calcium heparin

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Targeting Oxidative Stress in Chronic Beryllium Disease Completed NCT01088243 Phase 1, Phase 2 Mesalamine;Placebo
2 Beryllium Infliximab Study: Clinical Interventional Trial Terminated NCT00111917 Phase 1, Phase 2 Infliximab
3 The Role of JAK2 in Alveolar Macrophages (AM's) in Chronic Beryllium Disease (CBD) Unknown status NCT02596347
4 Identifying Shared Genetic Susceptibility Regions in Chronic Beryllium Disease and Sarcoidosis Completed NCT00560989
5 Exposure in Epigenetic Regulation of Immune Response in Chronic Beryllium Disease (CBD) Recruiting NCT02604693

Search NIH Clinical Center for Berylliosis

Cochrane evidence based reviews: berylliosis

Genetic Tests for Berylliosis

Anatomical Context for Berylliosis

MalaCards organs/tissues related to Berylliosis:

41
Lung, Liver, Testes, T Cells, Bone, Monocytes, Tonsil

The Foundational Model of Anatomy Ontology organs/tissues related to Berylliosis:

19
Lungs

Publications for Berylliosis

Articles related to Berylliosis:

(show top 50) (show all 126)
# Title Authors Year
1
Berylliosis (Chronic Beryllium Disease) ( 29261866 )
2017
2
Role of high-affinity HLA-DP specific CLIP-derived peptides in beryllium binding to the HLA-DPGlu69 berylliosis-associated molecules and presentation to beryllium-sensitized T cells. ( 19191908 )
2009
3
Role of the berylliosis-associated HLA-DPGlu69 supratypic variant in determining the response to beryllium in a blood T-cells beryllium-stimulated proliferation test. ( 16315779 )
2005
4
Identification of HLA-DRPhebeta47 as the susceptibility marker of hypersensitivity to beryllium in individuals lacking the berylliosis-associated supratypic marker HLA-DPGlubeta69. ( 16098233 )
2005
5
Activation pathways implicate anti-HLA-DP and anti-LFA-1 antibodies as lead candidates for intervention in chronic berylliosis. ( 15778396 )
2005
6
IL-4 fails to regulate in vitro beryllium-induced cytokines in berylliosis. ( 11405518 )
2001
7
Beryllium binding to HLA-DP molecule carrying the marker of susceptibility to berylliosis glutamate beta 69. ( 11423174 )
2001
8
Analysis of differentially regulated mRNAs in peripheral blood monocytes of berylliosis patients after in vitro stimulation. ( 10954202 )
2000
9
Comparative effectiveness of Tiron (4,5-dihydroxy benzene 1,3-disulphonic acid disodium salt) and CaNa2EDTA with time after beryllium poisoning. ( 12557911 )
2000
10
Immunogenetic basis of environmental lung disease: lessons from the berylliosis model. ( 9877510 )
1998
11
Pulmonary epithelial cell injury and alveolar-capillary permeability in berylliosis. ( 9230733 )
1997
12
Interaction of genetic and exposure factors in the prevalence of berylliosis. ( 9258386 )
1997
13
Beryllium induces IL-2 and IFN-gamma in berylliosis. ( 8977230 )
1997
14
Chronic berylliosis of the lung: report of a case. ( 16892748 )
1996
15
The computed tomographic appearances in chronic berylliosis. ( 8428413 )
1993
16
Scintigraphy with J001X, a Klebsiella membrane glycolipid, for the early diagnosis of chronic berylliosis: results from an experimental model. ( 1599873 )
1992
17
Berylliosis. ( 2138073 )
1990
18
A study of immunological indices for diagnosis of chronic berylliosis. ( 2604898 )
1989
19
Chronic berylliosis. Demonstration by gallium-67 imaging and magnetic resonance imaging. ( 3168359 )
1988
20
Pulmonary berylliosis on corticosteroid therapy, with cavitating lung lesions and aspergillomata--report on a fatal case. ( 3328191 )
1987
21
Bronchoalveolar lavage in a patient with chronic berylliosis: evidence for hypersensitivity pneumonitis. ( 7103279 )
1982
22
Pathologic liver changes in beryllium poisoning. ( 6819923 )
1982
23
Inhalant granulomas: silicosis, asbestosis, berylliosis. ( 7133715 )
1982
24
Pulmonary berylliosis: report on a fatal case. ( 7126443 )
1982
25
Berylliosis. ( 7381961 )
1980
26
Non-bony uptake of technetium-99m MDP in berylliosis. ( 7437734 )
1980
27
Mixed pneumoconiosis: silicosis, asbestosis, talcosis, and berylliosis. ( 436529 )
1979
28
Experimental pulmonary berylliosis in rabbits sensitized to beryllium sulfate: contact hypersensitivity. ( 159411 )
1979
29
Experimental aerogenic pulmonary berylliosis in rabbits. ( 147415 )
1978
30
Concentration of immunoglobulins in berylliosis. ( 564365 )
1977
31
Berylliosis as an auto-immune disorder. ( 942183 )
1976
32
Research into what happens in berylliosis. ( 1048889 )
1976
33
Case report. Pulmonary berylliosis following exposure to beryllium-copper. ( 1063889 )
1976
34
The influence of cutaneous hypersensitivity to beryllium on the development of experimental pulmonary berylliosis. ( 4533844 )
1974
35
Chronic berylliosis. ( 4526035 )
1974
36
Immunologic aspects of chronic berylliosis. ( 4540228 )
1973
37
A study of the immunologic aspects of chronic berylliosis. ( 4690875 )
1973
38
Chronic berylliosis. ( 4274186 )
1973
39
In vitro demonstration of delayed hypersensitivity in patients with berylliosis. ( 5061834 )
1972
40
Immunity to pulmonary berylliosis in guinea pigs. ( 5036157 )
1972
41
Lymphocyte transformation in chronic pulmonary berylliosis. ( 4112354 )
1972
42
The role of immunologic reactions in pulmonary berylliosis. ( 5527729 )
1970
43
Immunoglobulin levels in berylliosis. ( 4129664 )
1970
44
Immunoglobulin concentrationsn berylliosis. ( 4191591 )
1970
45
Serological reactions of berylliosis patients to extracts of lung tissue. ( 5644743 )
1968
46
Beryllium poisoning. ( 5743715 )
1968
47
Pulmonary berylliosis: a case report. ( 6083249 )
1967
48
Biochemical changes in rat liver after acute beryllium poisoning. ( 6029914 )
1967
49
Chronic berylliosis and calcospherite deposition. ( 5901642 )
1966
50
Beryllium poisoning. ( 4161383 )
1966

Variations for Berylliosis

Expression for Berylliosis

Search GEO for disease gene expression data for Berylliosis.

Pathways for Berylliosis

Pathways related to Berylliosis according to GeneCards Suite gene sharing:

(show all 41)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.69 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG IL2 POMC
2
Show member pathways
12.94 HLA-DPA1 HLA-DRB1 IFNG IL2
3
Show member pathways
12.91 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG IL2 POMC
4
Show member pathways
12.61 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG IL2
5
Show member pathways
12.34 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG IL2
6
Show member pathways
12.32 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG
7 12.2 HLA-DPA1 HLA-DPB1 HLA-DRB1 IL2
8
Show member pathways
12.19 HLA-DPA1 HLA-DRB1 IL2
9
Show member pathways
12.15 HLA-DPA1 HLA-DPB1 HLA-DRB1
10
Show member pathways
12.11 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG IL2
11 12.1 HLA-DPA1 HLA-DPB1 HLA-DRB1
12
Show member pathways
12.03 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG
13
Show member pathways
12.02 HLA-DPA1 HLA-DPB1 HLA-DRB1
14 11.99 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG
15 11.96 HLA-DPA1 HLA-DPB1 HLA-DRB1
16 11.92 HLA-DPA1 HLA-DPB1 HLA-DRB1
17
Show member pathways
11.89 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG IL2
18
Show member pathways
11.81 HLA-DRB1 IFNG IL2
19
Show member pathways
11.78 HLA-DPA1 HLA-DPB1 HLA-DRB1
20
Show member pathways
11.75 HLA-DPA1 HLA-DPB1 HLA-DRB1
21 11.75 HLA-DPA1 HLA-DPB1 HLA-DRB1
22 11.75 HLA-DPA1 HLA-DPB1 HLA-DRB1
23 11.71 HLA-DPA1 HLA-DPB1 HLA-DRB1
24 11.63 IFNG IL2 POMC
25 11.59 IFNG IL2
26
Show member pathways
11.56 IFNG IL2
27 11.55 IFNG IL2
28 11.53 HLA-DPA1 HLA-DRB1
29 11.52 IFNG IL2
30 11.49 IFNG IL2
31
Show member pathways
11.47 IFNG IL2
32
Show member pathways
11.45 IFNG IL2
33 11.43 HLA-DPA1 HLA-DPB1 HLA-DRB1
34 11.37 IFNG IL2
35 11.34 IFNG IL2
36 11.31 IFNG IL2
37 11.16 IFNG IL2
38 11.05 IFNG IL2
39 11.04 HLA-DRB1 IFNG IL2
40 10.99 HLA-DRB1 IFNG IL2
41 10.88 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG

GO Terms for Berylliosis

Cellular components related to Berylliosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lysosome GO:0005764 9.65 HLA-DPA1 HLA-DPB1 HLA-DRB1
2 lysosomal membrane GO:0005765 9.63 HLA-DPA1 HLA-DPB1 HLA-DRB1
3 endosome membrane GO:0010008 9.61 HLA-DPA1 HLA-DPB1 HLA-DRB1
4 trans-Golgi network membrane GO:0032588 9.58 HLA-DPA1 HLA-DPB1 HLA-DRB1
5 endocytic vesicle membrane GO:0030666 9.54 HLA-DPA1 HLA-DPB1 HLA-DRB1
6 ER to Golgi transport vesicle membrane GO:0012507 9.5 HLA-DPA1 HLA-DPB1 HLA-DRB1
7 transport vesicle membrane GO:0030658 9.43 HLA-DPA1 HLA-DPB1 HLA-DRB1
8 clathrin-coated endocytic vesicle membrane GO:0030669 9.33 HLA-DPA1 HLA-DPB1 HLA-DRB1
9 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.13 HLA-DPA1 HLA-DPB1 HLA-DRB1
10 MHC class II protein complex GO:0042613 8.8 HLA-DPA1 HLA-DPB1 HLA-DRB1

Biological processes related to Berylliosis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.76 HLA-DPA1 HLA-DPB1 HLA-DRB1 IL2
2 regulation of signaling receptor activity GO:0010469 9.69 POMC IFNG IL2
3 T cell receptor signaling pathway GO:0050852 9.61 HLA-DPA1 HLA-DPB1 HLA-DRB1
4 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.58 HLA-DPA1 HLA-DPB1 HLA-DRB1
5 immune response GO:0006955 9.55 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG IL2
6 positive regulation of T cell proliferation GO:0042102 9.54 HLA-DPA1 HLA-DPB1 IL2
7 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.52 IFNG IL2
8 positive regulation of interferon-gamma production GO:0032729 9.5 HLA-DPA1 HLA-DPB1 IL2
9 positive regulation of T cell activation GO:0050870 9.49 HLA-DPA1 HLA-DPB1
10 regulation of regulatory T cell differentiation GO:0045589 9.48 IFNG IL2
11 antigen processing and presentation GO:0019882 9.43 HLA-DPA1 HLA-DPB1 HLA-DRB1
12 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.13 HLA-DPA1 HLA-DPB1 HLA-DRB1
13 interferon-gamma-mediated signaling pathway GO:0060333 8.92 HLA-DRB1 HLA-DPB1 HLA-DPA1 IFNG

Molecular functions related to Berylliosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MHC class II receptor activity GO:0032395 8.96 HLA-DPA1 HLA-DRB1
2 peptide antigen binding GO:0042605 8.8 HLA-DPA1 HLA-DPB1 HLA-DRB1

Sources for Berylliosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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