MCID: BRY001
MIFTS: 43

Berylliosis

Categories: Immune diseases, Respiratory diseases

Aliases & Classifications for Berylliosis

MalaCards integrated aliases for Berylliosis:

Name: Berylliosis 12 77 45 15 17
Beryllium Poisoning 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10322
MeSH 45 D001607
SNOMED-CT 69 8247009
ICD10 34 J63.2
UMLS 74 C0005138

Summaries for Berylliosis

Disease Ontology : 12 A pneumoconiosis that involves allergic response located in lungs caused by inhalation of beryllium compounds.

MalaCards based summary : Berylliosis, also known as beryllium poisoning, is related to chronic beryllium disease and beryllium disease. An important gene associated with Berylliosis is HLA-DPA1 (Major Histocompatibility Complex, Class II, DP Alpha 1), and among its related pathways/superpathways are Innate Immune System and IL-2 Pathway. The drugs Infliximab and Anti-Inflammatory Agents have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and bone.

Wikipedia : 77 Berylliosis, or chronic beryllium disease (CBD), is a chronic allergic-type lung response and chronic... more...

Related Diseases for Berylliosis

Diseases related to Berylliosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 100)
# Related Disease Score Top Affiliating Genes
1 chronic beryllium disease 32.5 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG
2 beryllium disease 32.5 HLA-DPA1 HLA-DPB1 HLA-DRB1
3 rheumatic fever 30.1 HLA-DRB1 IL2
4 silicosis 10.3
5 asbestosis 10.2
6 asbestos intoxication 10.2
7 conjunctivitis 10.2 IFNG IL2
8 variola major 10.2 IFNG IL2
9 fixed drug eruption 10.2 IFNG IL2
10 atopic keratoconjunctivitis 10.2 IFNG IL2
11 keratoconjunctivitis 10.2 IFNG IL2
12 mucinoses 10.2 IFNG POMC
13 clonorchiasis 10.2 IFNG IL2
14 pericardial tuberculosis 10.2 IFNG POMC
15 crohn's colitis 10.2 IFNG IL2
16 chronic active epstein-barr virus infection 10.2 IFNG IL2
17 intermediate uveitis 10.2 IFNG IL2
18 posterior uveitis 10.2 IFNG IL2
19 erythema multiforme 10.1 IFNG IL2
20 coccidiosis 10.1 IFNG IL2
21 hematopoietic stem cell transplantation 10.1 IFNG IL2
22 stevens-johnson syndrome/toxic epidermal necrolysis 10.1 IFNG IL2
23 autoimmune disease of endocrine system 10.1 IFNG IL2
24 hypersensitivity reaction type iv disease 10.1 IFNG IL2
25 leprosy 3 10.1 IFNG IL2
26 acute graft versus host disease 10.1 IFNG IL2
27 tuberculous empyema 10.1 IL2 POMC
28 lepromatous leprosy 10.1 IFNG IL2
29 autoimmune uveitis 10.1 IFNG IL2
30 paracoccidioidomycosis 10.1 IFNG IL2
31 testicular disease 10.1 IFNG IL2
32 pleurisy 10.1 IFNG IL2
33 acute disseminated encephalomyelitis 10.1 HLA-DPA1 HLA-DRB1
34 herpes zoster 10.1 IFNG IL2
35 brucellosis 10.1 IFNG IL2
36 tropical spastic paraparesis 10.1 IFNG IL2
37 human immunodeficiency virus infectious disease 10.1 IFNG IL2
38 eosinophilia-myalgia syndrome 10.1 HLA-DRB1 IFNG
39 tonsillitis 10.1 IFNG IL2
40 microscopic colitis 10.1 HLA-DRB1 IFNG
41 central nervous system vasculitis 10.1 HLA-DRB1 IFNG
42 smallpox 10.1 IFNG IL2
43 idiopathic bronchiectasis 10.1 HLA-DRB1 IFNG
44 histoplasmosis 10.1 HLA-DRB1 IFNG
45 chronic inflammatory demyelinating polyradiculoneuropathy 10.1 HLA-DRB1 IFNG
46 polyradiculoneuropathy 10.1 HLA-DRB1 IFNG
47 parasitic protozoa infectious disease 10.1 IFNG IL2
48 peanut allergy 10.1 HLA-DRB1 IFNG
49 filariasis 10.1 IFNG IL2
50 alopecia areata 10.1 IFNG IL2

Graphical network of the top 20 diseases related to Berylliosis:



Diseases related to Berylliosis

Symptoms & Phenotypes for Berylliosis

Drugs & Therapeutics for Berylliosis

Drugs for Berylliosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved Phase 1, Phase 2 170277-31-3
2 Anti-Inflammatory Agents Phase 1, Phase 2
3 Antirheumatic Agents Phase 1, Phase 2,Phase 2
4 Analgesics, Non-Narcotic Phase 1, Phase 2
5 Mesalamine Phase 1, Phase 2 89-57-6
6 Analgesics Phase 1, Phase 2
7 Peripheral Nervous System Agents Phase 1, Phase 2
8 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
9 Gastrointestinal Agents Phase 1, Phase 2
10 Dermatologic Agents Phase 1, Phase 2
11
Heparin Approved, Investigational 9005-49-6 46507594 772
12 Pharmaceutical Solutions
13 calcium heparin

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Targeting Oxidative Stress in Chronic Beryllium Disease Completed NCT01088243 Phase 1, Phase 2 Mesalamine;Placebo
2 Beryllium Infliximab Study: Clinical Interventional Trial Terminated NCT00111917 Phase 1, Phase 2 Infliximab
3 The Role of JAK2 in Alveolar Macrophages (AM's) in Chronic Beryllium Disease (CBD) Unknown status NCT02596347
4 Identifying Shared Genetic Susceptibility Regions in Chronic Beryllium Disease and Sarcoidosis Completed NCT00560989
5 Exposure in Epigenetic Regulation of Immune Response in Chronic Beryllium Disease (CBD) Recruiting NCT02604693

Search NIH Clinical Center for Berylliosis

Cochrane evidence based reviews: berylliosis

Genetic Tests for Berylliosis

Anatomical Context for Berylliosis

MalaCards organs/tissues related to Berylliosis:

42
Lung, T Cells, Bone, Liver, Testes, Monocytes, Tonsil

The Foundational Model of Anatomy Ontology organs/tissues related to Berylliosis:

20
Lungs

Publications for Berylliosis

Articles related to Berylliosis:

(show top 50) (show all 125)
# Title Authors Year
1
Role of high-affinity HLA-DP specific CLIP-derived peptides in beryllium binding to the HLA-DPGlu69 berylliosis-associated molecules and presentation to beryllium-sensitized T cells. ( 19191908 )
2009
2
Activation pathways implicate anti-HLA-DP and anti-LFA-1 antibodies as lead candidates for intervention in chronic berylliosis. ( 15778396 )
2005
3
Identification of HLA-DRPhebeta47 as the susceptibility marker of hypersensitivity to beryllium in individuals lacking the berylliosis-associated supratypic marker HLA-DPGlubeta69. ( 16098233 )
2005
4
Role of the berylliosis-associated HLA-DPGlu69 supratypic variant in determining the response to beryllium in a blood T-cells beryllium-stimulated proliferation test. ( 16315779 )
2005
5
IL-4 fails to regulate in vitro beryllium-induced cytokines in berylliosis. ( 11405518 )
2001
6
Beryllium binding to HLA-DP molecule carrying the marker of susceptibility to berylliosis glutamate beta 69. ( 11423174 )
2001
7
Analysis of differentially regulated mRNAs in peripheral blood monocytes of berylliosis patients after in vitro stimulation. ( 10954202 )
2000
8
Comparative effectiveness of Tiron (4,5-dihydroxy benzene 1,3-disulphonic acid disodium salt) and CaNa2EDTA with time after beryllium poisoning. ( 12557911 )
2000
9
Immunogenetic basis of environmental lung disease: lessons from the berylliosis model. ( 9877510 )
1998
10
Beryllium induces IL-2 and IFN-gamma in berylliosis. ( 8977230 )
1997
11
Pulmonary epithelial cell injury and alveolar-capillary permeability in berylliosis. ( 9230733 )
1997
12
Interaction of genetic and exposure factors in the prevalence of berylliosis. ( 9258386 )
1997
13
Chronic berylliosis of the lung: report of a case. ( 16892748 )
1996
14
The computed tomographic appearances in chronic berylliosis. ( 8428413 )
1993
15
Scintigraphy with J001X, a Klebsiella membrane glycolipid, for the early diagnosis of chronic berylliosis: results from an experimental model. ( 1599873 )
1992
16
Berylliosis. ( 2138073 )
1990
17
A study of immunological indices for diagnosis of chronic berylliosis. ( 2604898 )
1989
18
Chronic berylliosis. Demonstration by gallium-67 imaging and magnetic resonance imaging. ( 3168359 )
1988
19
Pulmonary berylliosis on corticosteroid therapy, with cavitating lung lesions and aspergillomata--report on a fatal case. ( 3328191 )
1987
20
Inhalant granulomas: silicosis, asbestosis, berylliosis. ( 7133715 )
1982
21
Bronchoalveolar lavage in a patient with chronic berylliosis: evidence for hypersensitivity pneumonitis. ( 7103279 )
1982
22
Pulmonary berylliosis: report on a fatal case. ( 7126443 )
1982
23
Pathologic liver changes in beryllium poisoning. ( 6819923 )
1982
24
Berylliosis. ( 7381961 )
1980
25
Non-bony uptake of technetium-99m MDP in berylliosis. ( 7437734 )
1980
26
Mixed pneumoconiosis: silicosis, asbestosis, talcosis, and berylliosis. ( 436529 )
1979
27
Experimental pulmonary berylliosis in rabbits sensitized to beryllium sulfate: contact hypersensitivity. ( 159411 )
1979
28
Experimental aerogenic pulmonary berylliosis in rabbits. ( 147415 )
1978
29
Concentration of immunoglobulins in berylliosis. ( 564365 )
1977
30
Berylliosis as an auto-immune disorder. ( 942183 )
1976
31
Research into what happens in berylliosis. ( 1048889 )
1976
32
Case report. Pulmonary berylliosis following exposure to beryllium-copper. ( 1063889 )
1976
33
Chronic berylliosis. ( 4526035 )
1974
34
The influence of cutaneous hypersensitivity to beryllium on the development of experimental pulmonary berylliosis. ( 4533844 )
1974
35
Chronic berylliosis. ( 4274186 )
1973
36
Immunologic aspects of chronic berylliosis. ( 4540228 )
1973
37
A study of the immunologic aspects of chronic berylliosis. ( 4690875 )
1973
38
Lymphocyte transformation in chronic pulmonary berylliosis. ( 4112354 )
1972
39
Immunity to pulmonary berylliosis in guinea pigs. ( 5036157 )
1972
40
In vitro demonstration of delayed hypersensitivity in patients with berylliosis. ( 5061834 )
1972
41
Immunoglobulin levels in berylliosis. ( 4129664 )
1970
42
Immunoglobulin concentrationsn berylliosis. ( 4191591 )
1970
43
The role of immunologic reactions in pulmonary berylliosis. ( 5527729 )
1970
44
Serological reactions of berylliosis patients to extracts of lung tissue. ( 5644743 )
1968
45
Beryllium poisoning. ( 5743715 )
1968
46
Pulmonary berylliosis: a case report. ( 6083249 )
1967
47
Biochemical changes in rat liver after acute beryllium poisoning. ( 6029914 )
1967
48
Chronic berylliosis and calcospherite deposition. ( 5901642 )
1966
49
Beryllium poisoning. ( 4161383 )
1966
50
Beryllium poisoning--lessons in control of man-made disease. ( 5847559 )
1965

Variations for Berylliosis

Expression for Berylliosis

Search GEO for disease gene expression data for Berylliosis.

Pathways for Berylliosis

Pathways related to Berylliosis according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.68 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG IL2 POMC
2
Show member pathways
12.93 HLA-DPA1 HLA-DRB1 IFNG IL2
3
Show member pathways
12.84 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG IL2 POMC
4
Show member pathways
12.59 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG IL2
5
Show member pathways
12.3 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG
6
Show member pathways
12.18 HLA-DPA1 HLA-DRB1 IL2
7
Show member pathways
12.14 HLA-DPA1 HLA-DPB1 HLA-DRB1
8 12.12 HLA-DPA1 HLA-DPB1 HLA-DRB1 IL2
9
Show member pathways
12.11 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG IL2
10
Show member pathways
12.01 HLA-DPA1 HLA-DPB1 HLA-DRB1
11
Show member pathways
12.01 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG
12 11.96 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG
13 11.95 HLA-DPA1 HLA-DPB1 HLA-DRB1
14 11.92 HLA-DPA1 HLA-DPB1 HLA-DRB1
15
Show member pathways
11.89 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG IL2
16
Show member pathways
11.8 HLA-DRB1 IFNG IL2
17
Show member pathways
11.77 HLA-DPA1 HLA-DPB1 HLA-DRB1
18
Show member pathways
11.74 HLA-DPA1 HLA-DPB1 HLA-DRB1
19 11.74 HLA-DPA1 HLA-DPB1 HLA-DRB1
20 11.74 HLA-DPA1 HLA-DPB1 HLA-DRB1
21 11.7 HLA-DPA1 HLA-DPB1 HLA-DRB1
22 11.65 IL2 POMC
23 11.61 IFNG IL2 POMC
24 11.58 IFNG IL2
25
Show member pathways
11.56 IFNG IL2
26 11.54 IFNG IL2
27 11.52 HLA-DPA1 HLA-DRB1
28 11.52 IFNG IL2
29 11.5 HLA-DPA1 HLA-DPB1 HLA-DRB1
30 11.48 IFNG IL2
31
Show member pathways
11.46 IFNG IL2
32
Show member pathways
11.44 IFNG IL2
33 11.36 IFNG IL2
34 11.33 IFNG IL2
35 11.3 IFNG IL2
36 11.15 IFNG IL2
37 11.04 IFNG IL2
38 11.01 HLA-DRB1 IFNG IL2
39 10.94 HLA-DRB1 IFNG IL2
40 10.88 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG

GO Terms for Berylliosis

Cellular components related to Berylliosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lysosome GO:0005764 9.65 HLA-DPA1 HLA-DPB1 HLA-DRB1
2 lysosomal membrane GO:0005765 9.63 HLA-DPA1 HLA-DPB1 HLA-DRB1
3 endosome membrane GO:0010008 9.61 HLA-DPA1 HLA-DPB1 HLA-DRB1
4 trans-Golgi network membrane GO:0032588 9.58 HLA-DPA1 HLA-DPB1 HLA-DRB1
5 endocytic vesicle membrane GO:0030666 9.54 HLA-DPA1 HLA-DPB1 HLA-DRB1
6 ER to Golgi transport vesicle membrane GO:0012507 9.5 HLA-DPA1 HLA-DPB1 HLA-DRB1
7 transport vesicle membrane GO:0030658 9.43 HLA-DPA1 HLA-DPB1 HLA-DRB1
8 clathrin-coated endocytic vesicle membrane GO:0030669 9.33 HLA-DPA1 HLA-DPB1 HLA-DRB1
9 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.13 HLA-DPA1 HLA-DPB1 HLA-DRB1
10 MHC class II protein complex GO:0042613 8.8 HLA-DPA1 HLA-DPB1 HLA-DRB1

Biological processes related to Berylliosis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.76 HLA-DPA1 HLA-DPB1 HLA-DRB1 IL2
2 regulation of signaling receptor activity GO:0010469 9.69 IFNG IL2 POMC
3 T cell receptor signaling pathway GO:0050852 9.61 HLA-DPA1 HLA-DPB1 HLA-DRB1
4 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.58 HLA-DPA1 HLA-DPB1 HLA-DRB1
5 immune response GO:0006955 9.55 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG IL2
6 positive regulation of T cell proliferation GO:0042102 9.54 HLA-DPA1 HLA-DPB1 IL2
7 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.52 IFNG IL2
8 positive regulation of interferon-gamma production GO:0032729 9.5 HLA-DPA1 HLA-DPB1 IL2
9 positive regulation of T cell activation GO:0050870 9.49 HLA-DPA1 HLA-DPB1
10 regulation of regulatory T cell differentiation GO:0045589 9.48 IFNG IL2
11 antigen processing and presentation GO:0019882 9.43 HLA-DPA1 HLA-DPB1 HLA-DRB1
12 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.13 HLA-DPA1 HLA-DPB1 HLA-DRB1
13 interferon-gamma-mediated signaling pathway GO:0060333 8.92 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG

Molecular functions related to Berylliosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MHC class II receptor activity GO:0032395 8.96 HLA-DPA1 HLA-DRB1
2 peptide antigen binding GO:0042605 8.8 HLA-DPA1 HLA-DPB1 HLA-DRB1

Sources for Berylliosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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