MCID: BRY001
MIFTS: 40

Berylliosis

Categories: Immune diseases, Respiratory diseases

Aliases & Classifications for Berylliosis

MalaCards integrated aliases for Berylliosis:

Name: Berylliosis 12 74 43 15 17 32
Beryllium Poisoning 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10322
MeSH 43 D001607
SNOMED-CT 67 8247009
ICD10 32 J63.2
UMLS 71 C0005138

Summaries for Berylliosis

Disease Ontology : 12 A pneumoconiosis that involves allergic response located in lungs caused by inhalation of beryllium compounds.

MalaCards based summary : Berylliosis, also known as beryllium poisoning, is related to beryllium disease and chronic beryllium disease. An important gene associated with Berylliosis is HLA-DPA1 (Major Histocompatibility Complex, Class II, DP Alpha 1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Allograft rejection. The drugs Infliximab and Mesalamine have been mentioned in the context of this disorder. Affiliated tissues include lungs, lung and liver.

Wikipedia : 74 Berylliosis, or chronic beryllium disease (CBD), is a chronic allergic-type lung response and chronic... more...

Related Diseases for Berylliosis

Diseases related to Berylliosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 130)
# Related Disease Score Top Affiliating Genes
1 beryllium disease 33.8 HLA-DRB1 HLA-DPB1 HLA-DPA1
2 chronic beryllium disease 33.6 IFNG HLA-DRB1 HLA-DPB1 HLA-DPA1
3 b-cell expansion with nfkb and t-cell anergy 30.4 IL2RB IL2
4 sarcoidosis 1 30.2 IL2RB IL2 IFNG HLA-DRB1 ACE
5 rheumatic fever 29.9 IL2 IFNG HLA-DRB1 ACE
6 silicosis 10.6
7 allergic hypersensitivity disease 10.5
8 recurrent respiratory papillomatosis 10.4 IL2 HLA-DRB1
9 fixed drug eruption 10.4 IL2 IFNG
10 atopic keratoconjunctivitis 10.4 IL2 IFNG
11 idiopathic bronchiectasis 10.4 IFNG HLA-DRB1
12 virus associated hemophagocytic syndrome 10.4 IL2RB IL2
13 skeletal tuberculosis 10.3 IFNG CFHR2
14 apple allergy 10.3 HLA-DRB1 HLA-DPB1
15 chronic active epstein-barr virus infection 10.3 IL2 IFNG
16 oral tuberculosis 10.3 IL2 IFNG
17 red cell aplasia 10.3 IL2 HLA-DRB1
18 eosinophilia-myalgia syndrome 10.3 IFNG HLA-DRB1
19 stevens-johnson syndrome/toxic epidermal necrolysis 10.3 IL2 IFNG
20 asbestosis 10.3
21 bronchitis 10.3
22 extrinsic allergic alveolitis 10.3
23 asbestos intoxication 10.3
24 mucocutaneous leishmaniasis 10.3 IL2 IFNG
25 clonorchiasis 10.3 IL2 IFNG
26 pars planitis 10.3 IL2 HLA-DRB1
27 tuberculoid leprosy 10.3 IL2 IFNG
28 central nervous system vasculitis 10.3 IFNG HLA-DRB1
29 boutonneuse fever 10.3 IL2RB IL2
30 brawny scleritis 10.3 IFNG ACE
31 conjunctival deposit 10.2 HLA-DRB1 ACE
32 ocular tuberculosis 10.2 IFNG ACE
33 pulmonary hypertension 10.2
34 pneumoconiosis 10.2
35 anthracosis 10.2
36 lung disease 10.2
37 miliary tuberculosis 10.2
38 idiopathic nephrotic syndrome 10.2 HLA-DRB1 ACE
39 fuchs' heterochromic uveitis 10.2 IFNG ACE
40 intermediate uveitis 10.2 IL2 IFNG HLA-DRB1
41 microscopic colitis 10.2 IL2 IFNG HLA-DRB1
42 autoimmune gastritis 10.2 IL2 IFNG HLA-DRB1
43 autoimmune disease of endocrine system 10.2 IL2 IFNG HLA-DRB1
44 autoimmune disease of gastrointestinal tract 10.2 IL2 IFNG HLA-DRB1
45 herpes zoster 10.2 IL2 IFNG HLA-DRB1
46 leprosy 3 10.2 IL2 IFNG HLA-DRB1
47 skin sarcoidosis 10.2 IL2 ACE
48 visceral leishmaniasis 10.2 IL2 IFNG HLA-DRB1
49 acute graft versus host disease 10.2 IL2RB IL2 IFNG
50 pulmonary tuberculosis 10.2 IL2 IFNG HLA-DRB1

Graphical network of the top 20 diseases related to Berylliosis:



Diseases related to Berylliosis

Symptoms & Phenotypes for Berylliosis

Drugs & Therapeutics for Berylliosis

Drugs for Berylliosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved Phase 1, Phase 2 170277-31-3
2 Mesalamine Phase 1, Phase 2 89-57-6
3 Analgesics, Non-Narcotic Phase 1, Phase 2
4 Analgesics Phase 1, Phase 2
5 Anti-Inflammatory Agents Phase 1, Phase 2
6 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
7 Antirheumatic Agents Phase 1, Phase 2
8 Dermatologic Agents Phase 1, Phase 2
9 Gastrointestinal Agents Phase 1, Phase 2
10
Heparin Approved, Investigational 9005-49-6 46507594 772
11 Pharmaceutical Solutions
12 calcium heparin

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Targeting Oxidative Stress in Chronic Beryllium Disease Completed NCT01088243 Phase 1, Phase 2 Mesalamine;Placebo
2 Clinical Efficacy of Remicade in Chronic Beryllium Disease: A Randomized, Double-Blind, Placebo-Controlled, Investigator Initiated Trial Terminated NCT00111917 Phase 1, Phase 2 Infliximab
3 The Role of JAK2 in Alveolar Macrophages in Chronic Beryllium Disease Unknown status NCT02596347
4 Shared Genetic Susceptibility in CBD and Sarcoidosis Completed NCT00560989
5 Exposure in Epigenetic Regulation of Immune Response in Chronic Beryllium Recruiting NCT02604693

Search NIH Clinical Center for Berylliosis

Cochrane evidence based reviews: berylliosis

Genetic Tests for Berylliosis

Anatomical Context for Berylliosis

The Foundational Model of Anatomy Ontology organs/tissues related to Berylliosis:

19
Lungs

MalaCards organs/tissues related to Berylliosis:

40
Lung, Liver, Testes, T Cells, Cortex, Adrenal Cortex, Bone

Publications for Berylliosis

Articles related to Berylliosis:

(show top 50) (show all 314)
# Title Authors PMID Year
1
[Diagnostic difficulties of chronic pulmonary berylliosis in France]. 61
32279890 2020
2
Berylliosis: A Granulomatosis to Remind Us of the Importance of Occupational History. 61
32245543 2020
3
Understanding the Localization of Berylliosis: Interaction of Be2+ with Carbohydrates and Related Biomimetic Ligands. 61
31702840 2019
4
Understanding the Localization of Berylliosis: Interaction of Be2+ with Carbohydrates and Related Biomimetic Ligands. 61
31498482 2019
5
Isothermal Titration Calorimetry of Be2+ with Phosphatidylserine Models Guides All-Atom Force-Field Development for Lipid-Ion Interactions. 61
30681857 2019
6
Prostate-Specific Membrane Antigen-Positive Manifestations of Chronic Beryllium Lung Disease. 61
30358624 2019
7
Fluctuating hypercalcaemia caused by cavitary Mycobacterium bovis pulmonary infection. 61
29374638 2018
8
High-Affinity Interactions of Beryllium(2+) with Phosphatidylserine Result in a Cross-Linking Effect Reducing Surface Recognition of the Lipid. 61
28872302 2017
9
Differential diagnosis of granulomatous lung disease: clues and pitfalls: Number 4 in the Series "Pathology for the clinician" Edited by Peter Dorfmüller and Alberto Cavazza. 61
28794143 2017
10
State-of-the-art nanopathological diagnostics. 61
28805487 2017
11
Sudden unexpected death due to severe pulmonary and cardiac sarcoidosis. 61
27379608 2016
12
Beryllium in exhaled breath condensate as a biomarker of occupational exposure in a primary aluminum production plant. 61
26306830 2016
13
[Epitheloid cell granulomas in bronchial invasive mucinous adenocarcinoma]. 61
25668608 2015
14
Significance of Polymorphisms and Expression of Enzyme-Encoding Genes Related to Glutathione in Hematopoietic Cancers and Solid Tumors. 61
26682223 2015
15
[Granulomatous interstitial lung diseases]. 61
25362776 2014
16
[Granulomatous lung and systemic diseases]. 61
23463460 2013
17
Study the effect of beryllium reflector poisoning on the Syrian MNSR. 61
22464933 2012
18
Hypercalcemia in two patients with sarcoidosis and Mycobacterium avium intracellulare not mediated by elevated vitamin D metabolites. 61
21760475 2011
19
Experimental leprosy: a model of epithelioid cell granuloma. 61
21342156 2011
20
HLA-DP, HLA-DQ, and HLA-DR have different requirements for invariant chain and HLA-DM. 61
20959457 2010
21
Cathepsin-K is a sensitive immunohistochemical marker for detection of micro-granulomas in hypersensitivity pneumonitis. 61
21086906 2010
22
Uncommon occupational lung diseases: high-resolution CT findings. 61
20028886 2010
23
Role of high-affinity HLA-DP specific CLIP-derived peptides in beryllium binding to the HLA-DPGlu69 berylliosis-associated molecules and presentation to beryllium-sensitized T cells. 61
19191908 2009
24
[Sarcoidosis]. 61
19367373 2009
25
Beryllium hypersensitivity and chronic beryllium lung disease. 61
19532033 2009
26
Hypercalcemia in a patient with disseminated paracoccidioidomycosis: a case report. 61
18691418 2008
27
Thoracic intramedullary sarcoidosis mimicking an intramedullary tumor. 61
18756925 2008
28
[Chronic berylliosis]. 61
17290317 2007
29
Genetic susceptibility in pneumoconiosis. 61
17161563 2007
30
[State of broncho-pulmonary system in berylliosis patients on distant follow-up period]. 61
17802736 2007
31
[A case of pleural sarcoidosis in which vats lung biopsy, obtained pleural and pulmonary lesions]. 61
17144583 2006
32
Cytotoxic agents in the treatment of laryngeal sarcoidosis: a case report and review of the literature. 61
16478657 2006
33
[Berylliosis in Italy: a case of "sarcoidosis" under the threshold limit value]. 61
17017386 2006
34
Pneumoconiosis: comparison of imaging and pathologic findings. 61
16418244 2006
35
[Other pneumoconioses]. 61
17273600 2006
36
Role of the berylliosis-associated HLA-DPGlu69 supratypic variant in determining the response to beryllium in a blood T-cells beryllium-stimulated proliferation test. 61
16315779 2005
37
Identification of HLA-DRPhebeta47 as the susceptibility marker of hypersensitivity to beryllium in individuals lacking the berylliosis-associated supratypic marker HLA-DPGlubeta69. 61
16098233 2005
38
Activation pathways implicate anti-HLA-DP and anti-LFA-1 antibodies as lead candidates for intervention in chronic berylliosis. 61
15778396 2005
39
[Chronic pulmonary berylliosis: a model of interaction between environment and genetic predisposition (Part 1). Mineralogy, toxicology, epidemiology and risk factors]. 61
16092164 2005
40
[Respiration biomechanics in patients with berylliosis and chronic toxico-chemical bronchitis]. 61
16281368 2005
41
The Angiotensin Converting Enzyme Insertion/Deletion polymorphism is not associated with an increased risk of death or bronchopulmonary dysplasia in ventilated very low birth weight infants. 61
15610555 2004
42
Proposed criteria for mixed-dust pneumoconiosis: definition, descriptions, and guidelines for pathologic diagnosis and clinical correlation. 61
15619211 2004
43
Analysis of time-dependent recovery from beryllium toxicity following chelation therapy and antioxidant supplementation. 61
15573530 2004
44
Role of the HLA-DP Glu 69 and the TNF-alpha TNF-alpha 2 gene markers in susceptibility to beryllium hypersensitivity. 61
15345185 2004
45
Analysis of TNF-alpha promoter polymorphisms in the susceptibility to beryllium hypersensitivity. 61
15127972 2004
46
[Clinical and functional tests for pulmonary hypertension and cor pulmonale in chronic pulmonary berylliosis and plutonium-induced pulmonary sclerosis]. 61
15124391 2004
47
Beryllium detection in human lung tissue using electron probe X-ray microanalysis. 61
14614058 2003
48
Case series: use of induced sputum in the evaluation of occupational lung diseases. 61
14738274 2003
49
Genetic epidemiological approaches to the study of lung disease. 61
16088533 2003
50
[Asthma, alveolitis, aspergillosis, berylliosis. What to do when there is allergic reaction of the lung?]. 61
12688025 2003

Variations for Berylliosis

Expression for Berylliosis

Search GEO for disease gene expression data for Berylliosis.

Pathways for Berylliosis

Pathways related to Berylliosis according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.2 IL2RB IL2 IFNG HLA-DRB1 HLA-DPB1 HLA-DPA1
2
Show member pathways
12.69 IL2 IFNG HLA-DRB1 HLA-DPB1 HLA-DPA1
3 12.64 IFNG HLA-DRB1 HLA-DPB1 HLA-DPA1
4
Show member pathways
12.45 IL2 IFNG HLA-DRB1 HLA-DPB1 HLA-DPA1
5
Show member pathways
12.38 IFNG HLA-DRB1 HLA-DPB1 HLA-DPA1
6
Show member pathways
12.34 IL2RB IL2 IFNG HLA-DRB1 HLA-DPB1 HLA-DPA1
7
Show member pathways
12.25 IL2RB IL2 HLA-DRB1 HLA-DPA1
8
Show member pathways
12.11 IFNG HLA-DRB1 HLA-DPB1 HLA-DPA1
9
Show member pathways
12.07 HLA-DRB1 HLA-DPB1 HLA-DPA1
10 12.07 IFNG HLA-DRB1 HLA-DPB1 HLA-DPA1
11 12 HLA-DRB1 HLA-DPB1 HLA-DPA1
12 11.98 HLA-DRB1 HLA-DPB1 HLA-DPA1
13
Show member pathways
11.93 IL2RB IL2 IFNG
14 11.86 IL2RB IL2 IFNG
15
Show member pathways
11.83 HLA-DRB1 HLA-DPB1 HLA-DPA1
16 11.8 HLA-DRB1 HLA-DPB1 HLA-DPA1
17 11.79 HLA-DRB1 HLA-DPB1 HLA-DPA1
18 11.77 HLA-DRB1 HLA-DPB1 HLA-DPA1
19 11.75 HLA-DRB1 HLA-DPB1 HLA-DPA1
20 11.69 IL2RB IL2 HLA-DRB1 HLA-DPB1 HLA-DPA1
21
Show member pathways
11.68 IL2RB IL2 IFNG HLA-DRB1
22 11.66 IL2RB IL2 IFNG
23
Show member pathways
11.64 IL2RB IL2 IFNG HLA-DRB1 HLA-DPB1 HLA-DPA1
24
Show member pathways
11.59 HLA-DRB1 HLA-DPB1 HLA-DPA1
25 11.53 IFNG HLA-DRB1 HLA-DPB1 HLA-DPA1
26
Show member pathways
11.52 IL2RB IL2 IFNG
27 11.36 IL2RB IL2 IFNG
28
Show member pathways
11.21 IL2RB IL2 IFNG
29 11.13 IL2RB IL2 IFNG
30 11.07 IL2 IFNG
31 11.04 IL2 IFNG HLA-DRB1
32 10.99 IL2 IFNG HLA-DRB1

GO Terms for Berylliosis

Cellular components related to Berylliosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endosome GO:0005768 9.83 IL2RB HLA-DRB1 HLA-DPB1 HLA-DPA1 ACE
2 lysosome GO:0005764 9.76 HLA-DRB1 HLA-DPB1 HLA-DPA1 ACE
3 trans-Golgi network membrane GO:0032588 9.58 HLA-DRB1 HLA-DPB1 HLA-DPA1
4 endocytic vesicle membrane GO:0030666 9.54 HLA-DRB1 HLA-DPB1 HLA-DPA1
5 ER to Golgi transport vesicle membrane GO:0012507 9.5 HLA-DRB1 HLA-DPB1 HLA-DPA1
6 transport vesicle membrane GO:0030658 9.43 HLA-DRB1 HLA-DPB1 HLA-DPA1
7 clathrin-coated endocytic vesicle membrane GO:0030669 9.33 HLA-DRB1 HLA-DPB1 HLA-DPA1
8 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.13 HLA-DRB1 HLA-DPB1 HLA-DPA1
9 MHC class II protein complex GO:0042613 8.8 HLA-DRB1 HLA-DPB1 HLA-DPA1

Biological processes related to Berylliosis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.77 IL2 IFNG HLA-DRB1 HLA-DPB1 HLA-DPA1
2 adaptive immune response GO:0002250 9.72 IL2 IFNG HLA-DRB1 HLA-DPB1 HLA-DPA1
3 positive regulation of protein phosphorylation GO:0001934 9.71 IL2 IFNG HLA-DRB1
4 T cell receptor signaling pathway GO:0050852 9.7 HLA-DRB1 HLA-DPB1 HLA-DPA1
5 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.63 HLA-DRB1 HLA-DPB1 HLA-DPA1
6 positive regulation of T cell proliferation GO:0042102 9.58 IL2 HLA-DPB1 HLA-DPA1
7 positive regulation of T cell activation GO:0050870 9.51 HLA-DPB1 HLA-DPA1
8 macrophage differentiation GO:0030225 9.49 IFNG HLA-DRB1
9 regulation of regulatory T cell differentiation GO:0045589 9.48 IL2 IFNG
10 interleukin-2-mediated signaling pathway GO:0038110 9.43 IL2RB IL2
11 positive regulation of interferon-gamma production GO:0032729 9.43 IL2 HLA-DPB1 HLA-DPA1
12 antigen processing and presentation GO:0019882 9.33 HLA-DRB1 HLA-DPB1 HLA-DPA1
13 interferon-gamma-mediated signaling pathway GO:0060333 9.26 IFNG HLA-DRB1 HLA-DPB1 HLA-DPA1
14 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 8.8 HLA-DRB1 HLA-DPB1 HLA-DPA1

Molecular functions related to Berylliosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MHC class II receptor activity GO:0032395 8.96 HLA-DRB1 HLA-DPA1
2 peptide antigen binding GO:0042605 8.8 HLA-DRB1 HLA-DPB1 HLA-DPA1

Sources for Berylliosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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