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MCID: BST003
MIFTS: 33

Bestiality

Categories: Mental diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Bestiality

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MalaCards integrated aliases for Bestiality:

Name: Bestiality 12 15 70
Zoophilia 12

Classifications:

MalaCards categories:
Anatomical: Mental diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:9336
ICD9CM 34 302.1
SNOMED-CT 67 154907002
UMLS 70 C0152186
Sources

Summaries for Bestiality

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MalaCards based summary : Bestiality, also known as zoophilia, is related to paraphilia disorder and impulse control disorder. An important gene associated with Bestiality is CPZ (Carboxypeptidase Z), and among its related pathways/superpathways are Peptide ligand-binding receptors and Circadian entrainment. Affiliated tissues include brain and placenta, and related phenotypes are shRNA abundance <= 50% and behavior/neurological

Wikipedia : 73 Zoophilia is a paraphilia involving a sexual fixation on non-human animals. Bestiality is cross-species... more...

Sources

Related Diseases for Bestiality

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Diseases related to Bestiality via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 131)
# Related Disease Score Top Affiliating Genes
1 paraphilia disorder 29.7 OXT MAOA DRD4 DRD2
2 impulse control disorder 28.5 SLC6A3 MAOA HTR2A DRD4 DRD3 DRD2
3 parkinson disease, late-onset 28.2 TTR SLC6A3 MAOA HTR2A DRD4 DRD3
4 autism 27.5 SLC6A3 OXTR OXT MAOA HTR2A DRD4
5 disease of mental health 26.3 TTR SLC6A3 OXTR OXT MAOA HTR2A
6 dissociative amnesia 10.3 CPZ COMT
7 dependent personality disorder 10.3 MAOA DRD4
8 exhibitionism 10.3 MAOA DRD4
9 conversion disorder 10.2 HTR2A COMT
10 schizoid personality disorder 10.2 DRD2 CPZ
11 atypical depressive disorder 10.2 MAOA HTR2A
12 early-onset schizophrenia 10.2 DRD2 DRD1
13 alcoholic neuropathy 10.2 TTR MAOA
14 traumatic brain injury 10.1 DRD2 COMT
15 brain injury 10.1 DRD2 COMT
16 opioid addiction 10.1 DRD2 COMT
17 agoraphobia 10.1 MAOA HTR2A COMT
18 obsessive-compulsive personality disorder 10.1 HTR2A DRD3 COMT
19 paranoid schizophrenia 10.1 MAOA HTR2A COMT
20 melancholia 10.1 MAOA HTR2A
21 pure autonomic failure 10.1 TTR MAOA
22 chronic fatigue syndrome 10.1 MAOA HTR2A COMT
23 kleptomania 10.1 MAOA DRD2 COMT
24 polysubstance abuse 10.1 DRD3 DRD2 COMT
25 brunner syndrome 10.0 MAOA COMT
26 cannabis abuse 10.0 DRD4 DRD2 COMT
27 narcissistic personality disorder 10.0 OXT MAOA
28 migraine without aura 10.0 DRD4 DRD3 DRD2
29 pedophilia 10.0 OXT MAOA
30 glossitis 10.0 TTR COMT
31 alcoholic psychosis 10.0 SLC6A3 HTR2A
32 somatization disorder 10.0 OXT COMT
33 schizotypal personality disorder 10.0 HTR2A COMT
34 mixed cerebral palsy 10.0 TTR SLC6A3
35 essential tremor 10.0 SLC6A3 DRD3 COMT
36 phimosis 9.9
37 transient pseudohypoaldosteronism 9.9
38 transvestism 9.9 OXT ALMS1
39 placenta praevia 9.9 OXTR OXT
40 tremor 9.9
41 flying phobia 9.9 OXT MAOA COMT
42 sexual sadism 9.9 OXT MAOA COMT
43 hyperprolactinemia 9.9 HTR2A DRD4 DRD2
44 hypoactive sexual desire disorder 9.9 OXT HTR2A
45 prosopagnosia 9.9 OXTR OXT CPZ
46 lipoid proteinosis of urbach and wiethe 9.9 OXTR OXT
47 psychosexual disorder 9.9 OXT HTR2A
48 myasthenic syndrome, congenital, 1a, slow-channel 9.9 OXT CPZ
49 drug psychosis 9.9 SLC6A3 DRD2 COMT
50 drug-induced mental disorder 9.9 SLC6A3 DRD2 COMT

Graphical network of the top 20 diseases related to Bestiality:



Diseases related to Bestiality
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Symptoms & Phenotypes for Bestiality

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GenomeRNAi Phenotypes related to Bestiality according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 shRNA abundance <= 50% GR00343-S 9.17 COMT DRD1 DRD2 DRD4 HTR2A MAOA

MGI Mouse Phenotypes related to Bestiality:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.1 ALMS1 COMT DRD1 DRD2 DRD3 DRD4
2 homeostasis/metabolism MP:0005376 9.93 ALMS1 COMT DRD1 DRD2 DRD3 DRD4
3 cardiovascular system MP:0005385 9.91 COMT DRD1 DRD2 DRD3 FOSB MAOA
4 nervous system MP:0003631 9.77 ALMS1 COMT DRD1 DRD2 DRD3 DRD4
5 renal/urinary system MP:0005367 9.23 ALMS1 COMT DRD2 DRD3 FOSB GREM1
Sources

Drugs & Therapeutics for Bestiality

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Search Clinical Trials , NIH Clinical Center for Bestiality

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Genetic Tests for Bestiality

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Anatomical Context for Bestiality

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MalaCards organs/tissues related to Bestiality:

40
Brain, Placenta
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Publications for Bestiality

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Articles related to Bestiality:

(show top 50) (show all 76)
# Title Authors PMID Year
1
A Rare Report of Clinical Lycanthropy in Obsessive-Compulsive and Related Disorders. 61
33754087 2021
2
Review of cases, case series and prevalence studies of zoophilia in the general population. 61
33648694 2021
3
Social Scientific Analysis of Human-Animal Sexual Interactions. 61
33019564 2020
4
Critiquing the Conception of "Crimes Against Nature": The Necessity for a New "Natural" Law. 61
33124489 2020
5
Concordance of Paraphilic Interests and Behaviors. 61
33112690 2020
6
Bestiality Among Sexually Violent Predators. 61
32409303 2020
7
Penal Sanctioning of Zoophilia in Light of the Legal Status of Animals-A Comparative Analysis of Fifteen European Countries. 61
32545616 2020
8
Stigmatization of Paraphilias and Psychological Conditions Linked to Sexual Offending. 61
32352329 2020
9
Profile of patients with penile cancer in the region with the highest worldwide incidence. 61
32076037 2020
10
Offenders convicted of child sexual exploitation material offences: characteristics of offenders and an exploration of judicial censure. 61
33679203 2020
11
Uncommon and/or bizarre features of dementia: part IV. 61
31552557 2019
12
Arrest and Prosecution of Animal Sex Abuse (Bestiality) Offenders in the United States, 1975-2015. 61
31097526 2019
13
Contemporary understanding of zoophilia - A multinational survey study. 61
30639855 2019
14
Digital Ethnography of Zoophilia - A Multinational Mixed-Methods Study. 61
29746216 2019
15
Bestiality: An introduction for legal and mental health professionals. 61
30306630 2018
16
[Review of cases of zoophilia in patients with Parkinson's disease]. 61
30039840 2018
17
Similar mechanisms of traumatic rectal injuries in patients who had anal sex with animals to those who were butt-fisted by human sexual partner. 61
28763709 2017
18
Zoophilia in an adolescent with high-functioning autism from Sri Lanka. 61
28714321 2017
19
An Exploratory Study of a New Kink Activity: "Pup Play". 61
26666883 2017
20
Bestiality in Forensically Committed Sexual Offenders: A Case Series. 61
27861903 2017
21
Zoophilia: Another Sexual Orientation? 61
27832371 2017
22
Veterinary Forensic Pathology of Animal Sexual Abuse. 61
27169881 2016
23
Childhood animal cruelty, bestiality, and the link to adult interpersonal violence. 61
27156990 2016
24
An Adolescent with Bestiality Behaviour: Psychological Evaluation and Community Health Concerns. 61
26917869 2016
25
Underreporting of bestiality among juvenile sex offenders: polygraph versus self-report. 61
24502368 2014
26
Digital and divergent: sexual behaviors on the Internet. 61
25492077 2014
27
Zoophilia and the law: legal responses to a rare paraphilia. 61
25492066 2014
28
Commentary: Zoophilia and the law. 61
25492067 2014
29
The woman who gave birth to a dog Monstrosity and bestiality in Quaestiones Medico-Legales by Paolo Zacchia. 61
25702383 2014
30
Zoophilia and Parkinson's disease. 61
23973014 2013
31
Sex with animals (SWA): behavioral characteristics and possible association with penile cancer. A multicenter study. 61
22023719 2012
32
Zoophilia and impulse control disorder in a patient with Parkinson disease. 61
22057400 2012
33
A new classification of zoophilia. 61
21315301 2011
34
The DSM diagnostic criteria for paraphilia not otherwise specified. 61
19779971 2010
35
Childhood bestiality: a potential precursor to adult interpersonal violence. 61
20124030 2010
36
A case of severe anal injury in an adolescent male due to bestial sexual experimentation. 61
19733331 2009
37
A case study of preferential bestiality. 61
18157625 2009
38
References to the paraphilias and sexual crimes in the Bible. 61
19239958 2009
39
Ethological, psychological and legal aspects of animal sexual abuse. 61
16019241 2006
40
Exploring the possible link between childhood and adolescent bestiality and interpersonal violence. 61
16731991 2006
41
Profile of men suffering from sexually transmitted infections in Pakistan. 61
16689488 2006
42
1. An uncommon case of zoophilia: a case report. 61
15895645 2005
43
[Zoophilia between pathology and normality. Presentation of 3 case reports and an internet survey]. 61
15197450 2005
44
The prosecution of Taiwan sexuality researcher and activist Josephine Ho. 61
15242216 2004
45
Zoophilia in men: a study of sexual interest in animals. 61
14574096 2003
46
Sexual offender containment: use of the postconviction polygraph. 61
12839915 2003
47
Profile of men suffering from sexually transmitted infections in Pakistan. 61
14552241 2003
48
Possible zoophilia associated with dopaminergic therapy in Parkinson disease. 61
12086551 2002
49
Zoophilia: a rare cause of traumatic injury to the rectum. 61
12091035 2002
50
A case study of preferential bestiality (zoophilia). 61
11803597 2002
Sources

Variations for Bestiality

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Expression for Bestiality

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Search GEO for disease gene expression data for Bestiality.
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Pathways for Bestiality

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Pathways related to Bestiality according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Peptide ligand-binding receptors 65
Show member pathways
 13.38 OXTR OXT HTR2A DRD4 DRD3 DRD2
2
Circadian entrainment 36
Show member pathways
 12.66 SLC6A3 MAOA DRD4 DRD3 DRD2 DRD1
3
Beta-Adrenergic Signaling 63
Show member pathways
 12.53 FOSB DRD4 DRD3 DRD2 DRD1
4
Dopamine-DARPP32 Feedback onto cAMP Pathway 63
12.12 DRD4 DRD3 DRD2 DRD1
5
cAMP signaling pathway 36
12.04 OXTR OXT DRD2 DRD1
7
Signaling in Gap Junctions 63
11.96 HTR2A DRD2 DRD1
8
Long-term potentiation 36
Show member pathways
 11.75 DRD4 DRD2 DRD1
9
GPCRs, Other 1
11.69 HTR2A DRD4 DRD3
10
Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics 60
Show member pathways
 11.68 DRD4 DRD3 DRD2
11
Amphetamine addiction 36
Show member pathways
 11.63 SLC6A3 MAOA FOSB DRD2 DRD1
12
Gap junction 36
11.6 HTR2A DRD2 DRD1
13
Monoamine GPCRs 1
Show member pathways
 11.4 HTR2A DRD4 DRD3 DRD2 DRD1
14
Biogenic Amine Synthesis 1
Show member pathways
 10.91 MAOA COMT
15
Neurotransmitter Clearance In The Synaptic Cleft 65
Show member pathways
 10.91 SLC6A3 MAOA COMT
16
noradrenaline and adrenaline degradation 1
Show member pathways
 10.72 MAOA COMT
17
Dopamine metabolism 1
10.67 MAOA COMT
18
Methylphenidate Pathway, Pharmacodynamics 60
Show member pathways
 10.53 SLC6A3 MAOA DRD4 DRD3 DRD2 DRD1
Sources

GO Terms for Bestiality

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Cellular components related to Bestiality according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.8 SLC6A3 OXTR HTR2A DRD4 DRD3 DRD2
2 axon GO:0030424 9.71 SLC6A3 HTR2A DRD2 COMT
3 glutamatergic synapse GO:0098978 9.67 HTR2A DRD4 DRD3 DRD2
4 dendritic spine GO:0043197 9.61 DRD2 DRD1 COMT
5 dendrite GO:0030425 9.55 HTR2A DRD4 DRD2 DRD1 COMT
6 dopaminergic synapse GO:0098691 9.32 SLC6A3 DRD2
7 integral component of presynaptic membrane GO:0099056 9.13 SLC6A3 HTR2A DRD2
8 integral component of postsynaptic membrane GO:0099055 8.8 SLC6A3 HTR2A DRD2

Biological processes related to Bestiality according to GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.29 TTR OXTR OXT HTR2A GREM1 DRD4
2 G protein-coupled receptor signaling pathway GO:0007186 10.22 OXTR OXT HTR2A DRD4 DRD3 DRD2
3 response to organic cyclic compound GO:0014070 9.95 SLC6A3 OXTR OXT COMT
4 positive regulation of cytosolic calcium ion concentration GO:0007204 9.92 OXTR OXT HTR2A
5 response to ethanol GO:0045471 9.91 SLC6A3 DRD3 DRD2
6 response to estradiol GO:0032355 9.91 TFPI OXTR OXT
7 cellular calcium ion homeostasis GO:0006874 9.91 HTR2A DRD4 DRD3 DRD2
8 positive regulation of cold-induced thermogenesis GO:0120162 9.9 OXTR OXT ALMS1
9 locomotory behavior GO:0007626 9.89 SLC6A3 DRD3 DRD2
10 memory GO:0007613 9.89 OXTR OXT HTR2A
11 female pregnancy GO:0007565 9.89 OXTR OXT FOSB COMT
12 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.87 HTR2A DRD4 DRD1
13 response to cAMP GO:0051591 9.85 SLC6A3 OXT FOSB
14 visual learning GO:0008542 9.84 DRD3 DRD2 DRD1
15 response to progesterone GO:0032570 9.84 OXTR OXT FOSB
16 social behavior GO:0035176 9.83 OXTR OXT DRD4 DRD3
17 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway GO:0051482 9.82 DRD3 DRD2 DRD1
18 response to morphine GO:0043278 9.81 FOSB DRD3 DRD2
19 regulation of dopamine secretion GO:0014059 9.8 HTR2A DRD3 DRD2
20 negative regulation of blood pressure GO:0045776 9.79 OXT DRD3 DRD2
21 arachidonic acid secretion GO:0050482 9.78 DRD4 DRD3 DRD2
22 negative regulation of protein secretion GO:0050709 9.77 DRD4 DRD3 DRD2
23 dopamine receptor signaling pathway GO:0007212 9.76 DRD4 DRD2 DRD1
24 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 9.75 DRD3 DRD2 DRD1
25 eating behavior GO:0042755 9.74 OXTR OXT
26 positive regulation of receptor internalization GO:0002092 9.74 GREM1 DRD2
27 positive regulation of blood pressure GO:0045777 9.74 OXTR OXT
28 negative regulation of adenylate cyclase activity GO:0007194 9.74 DRD3 DRD2
29 temperature homeostasis GO:0001659 9.74 HTR2A DRD2
30 positive regulation of renal sodium excretion GO:0035815 9.74 OXT DRD3 DRD2
31 response to iron ion GO:0010039 9.73 SLC6A3 DRD2
32 negative regulation of cytosolic calcium ion concentration GO:0051481 9.73 DRD3 DRD2
33 catecholamine metabolic process GO:0006584 9.73 MAOA COMT
34 G protein-coupled receptor internalization GO:0002031 9.73 DRD3 DRD2
35 sleep GO:0030431 9.73 OXTR OXT HTR2A
36 response to amphetamine GO:0001975 9.73 OXTR OXT DRD4 DRD2
37 grooming behavior GO:0007625 9.72 OXT DRD2
38 regulation of postsynaptic neurotransmitter receptor internalization GO:0099149 9.72 DRD4 DRD3
39 maternal behavior GO:0042711 9.72 OXTR OXT
40 neurotransmitter catabolic process GO:0042135 9.72 MAOA COMT
41 negative regulation of voltage-gated calcium channel activity GO:1901386 9.72 DRD4 DRD3 DRD2
42 adenylate cyclase-activating dopamine receptor signaling pathway GO:0007191 9.71 DRD3 DRD1
43 regulation of dopamine metabolic process GO:0042053 9.71 SLC6A3 DRD4
44 behavioral response to ethanol GO:0048149 9.71 DRD4 DRD2
45 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.71 HTR2A DRD3 DRD2
46 adenohypophysis development GO:0021984 9.7 SLC6A3 DRD2
47 hyaloid vascular plexus regression GO:1990384 9.7 SLC6A3 DRD2
48 positive regulation of uterine smooth muscle contraction GO:0070474 9.7 OXTR OXT
49 drinking behavior GO:0042756 9.7 OXT DRD2
50 negative regulation of gastric acid secretion GO:0060455 9.69 OXTR OXT

Molecular functions related to Bestiality according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor activity GO:0004930 9.73 OXTR HTR2A DRD4 DRD3 DRD2 DRD1
2 protein-containing complex binding GO:0044877 9.62 TTR SLC6A3 HTR2A DRD2
3 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591 9.33 DRD4 DRD3 DRD2
4 dopamine binding GO:0035240 9.26 SLC6A3 DRD4 DRD2 DRD1
5 dopamine neurotransmitter receptor activity GO:0004952 8.92 DRD4 DRD3 DRD2 DRD1
Sources

Sources for Bestiality

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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