MCID: BTL002
MIFTS: 36

Beta-Lactam Allergy

Categories: Immune diseases

Aliases & Classifications for Beta-Lactam Allergy

MalaCards integrated aliases for Beta-Lactam Allergy:

Name: Beta-Lactam Allergy 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060519

Summaries for Beta-Lactam Allergy

Disease Ontology : 12 A drug allergy triggered by a beta-lactam.

MalaCards based summary : Beta-Lactam Allergy is related to penicillin allergy and allergic hypersensitivity disease. An important gene associated with Beta-Lactam Allergy is IL4R (Interleukin 4 Receptor), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Clindamycin and Cefazolin have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and heart, and related phenotypes are hematopoietic system and homeostasis/metabolism

Related Diseases for Beta-Lactam Allergy

Diseases related to Beta-Lactam Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)
# Related Disease Score Top Affiliating Genes
1 penicillin allergy 31.4 STAT6 IL4R IL4 IL13 IFNGR1
2 allergic hypersensitivity disease 29.7 IL4R IL4 IL13 IL10
3 ige responsiveness, atopic 27.6 STAT6 IL4R IL4 IL21R IL13 IL10
4 benzylpenicillin allergy 11.6
5 amoxicillin allergy 11.6
6 piperacillin allergy 11.6
7 aztreonam allergy 11.6
8 meropenem allergy 11.6
9 drug allergy 10.5
10 pollen allergy 10.4 IL4R IL13
11 inflammatory bowel disease 4 10.3 IL4 IL13
12 exanthem 10.3
13 angiostrongyliasis 10.3 IL4 IL13
14 hyper ige syndrome 10.3 IL4R IL4
15 latex allergy 10.3 IL4 IL13
16 eosinophilic gastritis 10.3 IL4 IL13
17 chronic conjunctivitis 10.3 IL4 IL13
18 conjunctivitis 10.3 IL4 IL13
19 chronic tic disorder 10.3 IL4 IL13
20 vernal keratoconjunctivitis 10.3 IL4 IL13
21 keratoconjunctivitis 10.3 IL4 IL13
22 enterobiasis 10.3 IL4 IL13
23 conjunctival disease 10.3 IL4 IL13
24 pulmonary eosinophilia 10.3 IL4 IL13
25 otitis media 10.2
26 cephalosporin allergy 10.2
27 acute cystitis 10.2
28 onchocerciasis 10.2 IL4 IL13
29 allergic conjunctivitis 10.2 IL4 IL13
30 jak3-deficient severe combined immunodeficiency 10.1 STAT6 IL4
31 fibrosis of extraocular muscles, congenital, 1 10.1
32 cystic fibrosis 10.1
33 lymphoma, hodgkin, classic 10.1
34 myeloma, multiple 10.1
35 lymphoma, non-hodgkin, familial 10.1
36 neutropenia 10.1
37 urticaria 10.1
38 leukocyte disease 10.1 IL4 IL13
39 ascaridiasis 10.1 IL13 IL10
40 trichuriasis 10.1 IL13 IL10
41 rhinitis 10.0 IL4R IL4 IL13
42 peanut allergy 10.0 IL13 IL10
43 radiculopathy 10.0 IL13 IL10
44 allergic contact dermatitis 10.0 IL4 IL10
45 contact dermatitis 10.0 IL4 IL10
46 tropical endomyocardial fibrosis 9.9 IL4 IL10
47 endomyocardial fibrosis 9.9 IL4 IL10
48 hyperlucent lung 9.9 IL4 IL10
49 tungiasis 9.9 IL4 IL10
50 baylisascariasis 9.9 IL4 IL10

Graphical network of the top 20 diseases related to Beta-Lactam Allergy:



Diseases related to Beta-Lactam Allergy

Symptoms & Phenotypes for Beta-Lactam Allergy

MGI Mouse Phenotypes related to Beta-Lactam Allergy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.03 IFNGR1 IFNGR2 IL10 IL13 IL21R IL4
2 homeostasis/metabolism MP:0005376 10.01 IFNGR1 IFNGR2 IL10 IL13 IL21R IL4
3 endocrine/exocrine gland MP:0005379 10 IFNGR1 IL10 IL13 IL21R IL4 IL4R
4 immune system MP:0005387 9.97 IFNGR1 IFNGR2 IL10 IL13 IL21R IL4
5 digestive/alimentary MP:0005381 9.88 IFNGR1 IL10 IL13 IL4 IL4R
6 integument MP:0010771 9.8 IFNGR1 IL10 IL13 IL4 IL4R STAT6
7 mortality/aging MP:0010768 9.7 IFNGR1 IL10 IL13 IL21R IL4 IL4R
8 liver/biliary system MP:0005370 9.65 IFNGR1 IL10 IL4 IL4R STAT6
9 nervous system MP:0003631 9.43 IFNGR1 IL10 IL13 IL4 IL4R STAT6
10 respiratory system MP:0005388 9.02 IL10 IL13 IL4 IL4R STAT6

Drugs & Therapeutics for Beta-Lactam Allergy

Drugs for Beta-Lactam Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
2
Cefazolin Approved Phase 4 25953-19-9 656510 33255
3 Lactams Phase 4
4 Anti-Infective Agents Phase 4
5 beta-Lactams Phase 4
6 Clindamycin palmitate Phase 4
7 Antitubercular Agents Phase 4
8 Clindamycin phosphate Phase 4
9
Amoxicillin Approved, Vet_approved 26787-78-0 33613
10 penicillins
11 Anti-Bacterial Agents
12 Antibiotics, Antitubercular

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Antibiotics During Intrauterine Balloon Tamponade Placement Recruiting NCT03478163 Phase 4 CeFAZolin 1000 MG;Clindamycin 900 MG in 6 ML Injection
2 Extended Open Challenge in Patients With a History of Drug Eruption Following Beta-lactam Treatment Completed NCT01520181 Beta-lactam oral challenge
3 The Optimized Diagnostic Methods for the Confirmation of Penicillin/Aminopenicillin Allergy in Thailand Completed NCT01667055
4 Point of Care Group A Streptococcal Testing in a Pediatric Emergency Department: A Randomized Controlled Trial Not yet recruiting NCT03744832

Search NIH Clinical Center for Beta-Lactam Allergy

Genetic Tests for Beta-Lactam Allergy

Anatomical Context for Beta-Lactam Allergy

MalaCards organs/tissues related to Beta-Lactam Allergy:

41
Testes, Skin, Heart, Kidney

Publications for Beta-Lactam Allergy

Articles related to Beta-Lactam Allergy:

(show top 50) (show all 99)
# Title Authors PMID Year
1
Immediate cephalosporin allergy. 38
30667130 2019
2
Antibiotic Allergy in Children: More than Just a Label. 38
31394524 2019
3
The Basics of Penicillin Allergy: What A Clinician Should Know. 38
31319528 2019
4
Acute care beta-lactam allergy pathways: approaches and outcomes. 38
31009700 2019
5
Self-reported beta-lactam intolerance: not a class effect, dangerous to patients, and rarely allergy. 38
31067139 2019
6
Compliance Rate of Surgical Antimicrobial Prophylaxis and its Association with Knowledge of Guidelines Among Surgical Residents in a Tertiary Care Public Hospital of a Developing Country. 38
31367494 2019
7
Outcomes from an inpatient beta-lactam allergy guideline across a large US health system. 38
30915929 2019
8
Fosfomycin in the pediatric setting: Evidence and potential indications. 38
31131593 2019
9
Confronting the Challenge of Beta-Lactam Allergies: A Quasi-Experimental Study Assessing Impact of Pharmacy-Led Interventions. 38
29162022 2019
10
The role of skin testing and extended antibiotic courses in assessment of children with penicillin allergy: An Australian experience. 38
30209846 2019
11
Identifying Low-Risk Beta-Lactam Allergy Patients in a UK Tertiary Centre. 38
30922992 2019
12
Controversies in Drug Allergy: Drug Allergy Pathways. 38
30573422 2019
13
Controversies in Drug Allergy: Beta-Lactam Hypersensitivity Testing. 38
30245291 2019
14
Opportunities for antimicrobial stewardship in patients with acute bacterial skin and skin structure infections who are unsuitable for beta-lactam antibiotics: a multicenter prospective observational study. 38
30783523 2019
15
Polymorphisms in the interleukin 4 receptor and interleukin 13 genes in immediate allergic reactions to beta-lactam antibiotics: A case-control study. 38
30525746 2018
16
Appropriateness of Beta-Lactam Allergy Record Updates After an Allergy Service Consult. 38
30180773 2018
17
Hypersensitivity reactions to beta-lactams in children. 38
29870460 2018
18
Management of fever and neutropenia in children with cancer: A survey of Australian and New Zealand practice. 38
29655245 2018
19
The Impact of Reported Beta-Lactam Allergy in Hospitalized Patients With Hematologic Malignancies Requiring Antibiotics. 38
29346543 2018
20
Designing Predictive Models for Beta-Lactam Allergy Using the Drug Allergy and Hypersensitivity Database. 38
28739365 2018
21
Impact of a Standardized Beta-Lactam Allergy Questionnaire on Aztreonam Use. 38
29466923 2018
22
Evaluation of IFN-γ Enzyme-linked Immunospot Assay (ELISPOT) as a First-line Test in the Diagnosis of Non-Immediate Hypersensitivity to Amoxicillin and Penicillin. 38
29665345 2018
23
Hospitalizations in Children with a Penicillin Allergy Label: An Assessment of Healthcare Impact. 38
29788022 2018
24
[Hypersensitivity reactions to beta-lactam antibiotics]. 38
28754229 2017
25
Screening for Beta-Lactam Allergy in Joint Arthroplasty Patients to Improve Surgical Prophylaxis Practice. 38
28236547 2017
26
Addressing Inpatient Beta-Lactam Allergies: A Multihospital Implementation. 38
28483315 2017
27
Extended use of perioperative antibiotics in head and neck microvascular reconstruction. 38
28139320 2017
28
Frequency and Risk Factors of Penicillin and Amoxicillin Allergy in Suspected Patients with Drug Allergy. 38
28112529 2017
29
Impact of a pharmacist-driven beta-lactam allergy interview on inpatient antimicrobial therapy: A pilot project. 38
27745795 2016
30
The revolving door: antibiotic allergy labelling in a tertiary care centre. 38
27530619 2016
31
Impact of Reported Beta-Lactam Allergy on Inpatient Outcomes: A Multicenter Prospective Cohort Study. 38
27402820 2016
32
Empiric systemic antibiotics for hospitalized patients with severe odontogenic infections. 38
27369813 2016
33
Lack of uniformity in the investigation and management of suspected β-lactam allergy in children. 38
26920651 2016
34
Effectiveness of sequential intravenous-to-oral antibiotic switch therapy in hospitalized patients with gram-positive infection: the SEQUENCE cohort study. 38
27180242 2016
35
Adverse Drug Reactions Associated with Ceftaroline Use: A 2-Center Retrospective Cohort. 38
27130709 2016
36
Identifying opportunities in EHR to improve the quality of antibiotic allergy data. 38
26554427 2016
37
Prediction of Fluoroquinolone Resistance in Gram-Negative Bacteria Causing Bloodstream Infections. 38
26833166 2016
38
Documenting Penicillin Allergy: The Impact of Inconsistency. 38
26981866 2016
39
Prevalence of beta-lactam allergy: a retrospective chart review of drug allergy assessment in a predominantly pediatric population. 38
27956906 2016
40
Case Study of Intrapartum Antibiotic Prophylaxis and Subsequent Postpartum Beta-Lactam Anaphylaxis. 38
26178331 2015
41
Diagnosis of allergy against beta-lactams in primary care: prevalence and diagnostic criteria. 38
25851993 2015
42
Improving the Effectiveness of Penicillin Allergy De-labeling. 38
25609352 2015
43
Management of allergy to penicillins and other beta-lactams. 38
25623506 2015
44
Penicillin and beta-lactam allergy: epidemiology and diagnosis. 38
25216741 2014
45
Aztreonam for febrile neutropenia in patients with beta-lactam allergy. 38
24119095 2014
46
Desensitization in patients with beta-lactam drug allergy. 38
23177979 2013
47
Skin testing for Beta-lactam antibiotics: impact of the availability of a major determinant. 38
23232943 2013
48
Tigecycline use in patient with intra-abdominal abscess, beta-lactam allergy, and acute kidney injury. 38
23039235 2012
49
Evaluating the usefulness of retesting for beta-lactam allergy in children. 38
22673138 2012
50
Intracameral cefuroxime injection at the end of cataract surgery to reduce the incidence of endophthalmitis: French study. 38
22814043 2012

Variations for Beta-Lactam Allergy

Expression for Beta-Lactam Allergy

Search GEO for disease gene expression data for Beta-Lactam Allergy.

Pathways for Beta-Lactam Allergy

Pathways related to Beta-Lactam Allergy according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.75 STAT6 IL4R IL4 IL13 IL10 IFNGR2
2
Show member pathways
13.45 IL4R IL4 IL21R IL13 IL10 IFNGR2
3
Show member pathways
13.31 STAT6 IL4R IL4 IL13 IL10 IFNGR2
4
Show member pathways
13.19 STAT6 IL4R IL4 IL13 IL10
5
Show member pathways
13.13 STAT6 IL4R IL4 IL13 IL10 IFNGR2
6
Show member pathways
12.99 STAT6 IL4R IL4 IFNGR2 IFNGR1
7
Show member pathways
12.67 IL4R IL4 IL13 IL10 IFNGR2 IFNGR1
8 12.6 STAT6 IL4R IL4 IL13 IFNGR2 IFNGR1
9
Show member pathways
12.59 STAT6 IL4R IL4 IL21R
10
Show member pathways
12.45 IL4R IL4 IL10 IFNGR2 IFNGR1
11 12.37 STAT6 IL4 IL10
12
Show member pathways
12.32 IL4 IFNGR2 IFNGR1
13
Show member pathways
12.21 STAT6 IL4R IL4
14
Show member pathways
12.13 STAT6 IFNGR2 IFNGR1
15
Show member pathways
12.13 IL4 IL10 IFNGR2 IFNGR1
16
Show member pathways
12.1 STAT6 IL4R IL4 IL21R IL13 IL10
17
Show member pathways
12.06 IL4 IL13 IL10
18 12.06 IL10 IFNGR2 IFNGR1
19
Show member pathways
12.04 STAT6 IFNGR2 IFNGR1
20
Show member pathways
12.02 IL4 IFNGR2 IFNGR1
21
Show member pathways
11.93 IL21R IL10 IFNGR2 IFNGR1
22
Show member pathways
11.86 IL4R IL4 IL13 IL10 IFNGR2 IFNGR1
23 11.78 STAT6 IL4R IL4 IL13 IL10
24 11.68 IL4 IL13 IL10
25 11.62 IL4 IL13 IL10
26
Show member pathways
11.59 STAT6 IL4R IL4 IL21R IL13 IL10
27 11.58 STAT6 IL4R IL21R IL10 IFNGR2 IFNGR1
28 11.53 STAT6 IL4R IL4 IL10
29 11.48 IL4 IL13
30 11.48 IL4R IL21R IL10
31 11.44 IL4 IL13 IL10
32
Show member pathways
11.37 IFNGR2 IFNGR1
33 11.32 STAT6 IL4R IL4 IL13 IL10
34 11.3 IFNGR2 IFNGR1
35 11.23 IFNGR2 IFNGR1
36 11.19 IL4 IL13 IL10
37 11.18 IL4R IL4
38 11.16 IL4 IL13
39 11.13 IL4 IL13 IL10
40 11.04 IL4 IL13 IL10

GO Terms for Beta-Lactam Allergy

Biological processes related to Beta-Lactam Allergy according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.84 IL4R IL4 IL13 IL10
2 positive regulation of B cell proliferation GO:0030890 9.56 IL4 IL13
3 defense response to protozoan GO:0042832 9.55 IL4R IL10
4 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.52 IFNGR2 IFNGR1
5 positive regulation of mast cell degranulation GO:0043306 9.51 IL4R IL13
6 positive regulation of immunoglobulin production GO:0002639 9.49 IL4R IL13
7 positive regulation of MHC class II biosynthetic process GO:0045348 9.48 IL4 IL10
8 type 2 immune response GO:0042092 9.46 IL4 IL10
9 regulation of isotype switching GO:0045191 9.43 IL4 IL10
10 negative regulation of endothelial cell apoptotic process GO:2000352 9.43 IL4 IL13 IL10
11 interleukin-4-mediated signaling pathway GO:0035771 9.4 STAT6 IL4R
12 positive regulation of isotype switching to IgE isotypes GO:0048295 9.37 STAT6 IL4
13 positive regulation of macrophage activation GO:0043032 9.33 IL4R IL13 IL10
14 negative regulation of complement-dependent cytotoxicity GO:1903660 9.32 IL4 IL13
15 positive regulation of cold-induced thermogenesis GO:0120162 9.26 STAT6 IL4R IL4 IL13
16 cytokine-mediated signaling pathway GO:0019221 9.17 STAT6 IL4R IL4 IL13 IL10 IFNGR2

Molecular functions related to Beta-Lactam Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine receptor activity GO:0004896 9.26 IL4R IL21R
2 cytokine receptor binding GO:0005126 9.16 IL4 IL13
3 cytokine activity GO:0005125 9.13 IL4 IL13 IL10
4 interferon-gamma receptor activity GO:0004906 8.62 IFNGR2 IFNGR1

Sources for Beta-Lactam Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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