MCID: BTL002
MIFTS: 35

Beta-Lactam Allergy

Categories: Immune diseases

Aliases & Classifications for Beta-Lactam Allergy

MalaCards integrated aliases for Beta-Lactam Allergy:

Name: Beta-Lactam Allergy 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060519

Summaries for Beta-Lactam Allergy

Disease Ontology : 12 A drug allergy triggered by a beta-lactam.

MalaCards based summary : Beta-Lactam Allergy is related to amoxicillin allergy and otitis media. An important gene associated with Beta-Lactam Allergy is IL4R (Interleukin 4 Receptor), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Cefazolin and Clindamycin have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and lung, and related phenotypes are cellular and endocrine/exocrine gland

Related Diseases for Beta-Lactam Allergy

Diseases related to Beta-Lactam Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 145)
# Related Disease Score Top Affiliating Genes
1 amoxicillin allergy 32.2 IGHE ENPP3
2 otitis media 30.5 IL4 IL10 IGHE
3 penicillin allergy 30.4 STAT6 KAT8 IL4R IL4 IL13 IL10
4 drug allergy 29.7 KAT8 IL4R IGHE ENPP3
5 urticaria 29.4 IL4 IL13 IGHE ENPP3
6 ige responsiveness, atopic 28.2 STAT6 MS4A2 IL4R IL4 IL21R IL13
7 allergic hypersensitivity disease 28.0 STAT6 MS4A2 IL4R IL4 IL13 IL10
8 benzylpenicillin allergy 11.6
9 piperacillin allergy 11.6
10 aztreonam allergy 11.6
11 meropenem allergy 11.6
12 elephantiasis 10.4 IL4 IL10
13 tropical endomyocardial fibrosis 10.4 IL4 IL10
14 endomyocardial fibrosis 10.4 IL4 IL10
15 jak3-deficient severe combined immunodeficiency 10.4 STAT6 IL4
16 autoimmune hepatitis type 1 10.4 IL4 IL10
17 metal allergy 10.4 IL4 IL10
18 combined thymoma 10.4 IL13 IL10
19 nickel allergic contact dermatitis 10.4 IL4 IL10
20 orofacial granulomatosis 10.4 IL4 IL10
21 angiostrongyliasis 10.4 IL4 IL13
22 eales disease 10.3 IL4 IL10
23 exanthem 10.3
24 low-grade astrocytoma 10.3 STAT6 IL13
25 inflammatory bowel disease 18 10.3 IL4 IL10
26 axillary adenitis 10.3 IFNGR2 IFNGR1
27 tuberculous salpingitis 10.3 IFNGR2 IFNGR1
28 dacryoadenitis 10.3 IL13 IL10
29 mucocutaneous leishmaniasis 10.3 IL4 IL10
30 opportunistic bacterial infectious disease 10.3 IFNGR2 IFNGR1
31 idiopathic nephrotic syndrome 10.3 IL4 IGHE
32 atopic keratoconjunctivitis 10.3 IL4 IGHE
33 tuberculoid leprosy 10.3 IL4 IL10
34 taeniasis 10.3 IL4 IL10
35 lipoid nephrosis 10.3 IL4R IL13 IL10
36 esophagitis, eosinophilic, 1 10.3 STAT6 IL4 IL13
37 loiasis 10.3 IL4 IL13 IL10
38 trichinosis 10.3 IL4 IL13 IL10
39 mikulicz disease 10.3 IL4 IL13 IL10
40 idiopathic interstitial pneumonia 10.3 IL4R IL4 IL13
41 filarial elephantiasis 10.3 IL4 IL13 IL10
42 intestinal schistosomiasis 10.2 IL4 IL13 IL10
43 cephalosporin allergy 10.2
44 acute cystitis 10.2
45 toxic oil syndrome 10.2 IL4 IGHE
46 cryptococcosis 10.2 IL4 IL13 IL10
47 splenic disease 10.2 IL4 IL13 IL10
48 mycoplasma pneumoniae pneumonia 10.2 IL4 IL13 IL10
49 esophagitis 10.2 IL4 IL13 IL10
50 vernal conjunctivitis 10.2 IL4 IGHE

Graphical network of the top 20 diseases related to Beta-Lactam Allergy:



Diseases related to Beta-Lactam Allergy

Symptoms & Phenotypes for Beta-Lactam Allergy

MGI Mouse Phenotypes related to Beta-Lactam Allergy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.02 ETV5 IFNGR1 IFNGR2 IL10 IL13 IL4
2 endocrine/exocrine gland MP:0005379 9.86 ETV5 IFNGR1 IL10 IL13 IL21R IL4
3 hematopoietic system MP:0005397 9.85 ENPP3 IFNGR1 IFNGR2 IL10 IL13 IL21R
4 digestive/alimentary MP:0005381 9.8 ENPP3 IFNGR1 IL10 IL13 IL4 IL4R
5 immune system MP:0005387 9.65 ENPP3 IFNGR1 IFNGR2 IL10 IL13 IL21R
6 respiratory system MP:0005388 9.17 ENPP3 ETV5 IL10 IL13 IL4 IL4R

Drugs & Therapeutics for Beta-Lactam Allergy

Drugs for Beta-Lactam Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cefazolin Approved Phase 4 25953-19-9 656510 33255
2
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
3 Anti-Bacterial Agents Phase 4
4 beta-Lactams Phase 4
5 Lactams Phase 4
6 Anti-Infective Agents Phase 4
7 Antibiotics, Antitubercular Phase 4
8 Antitubercular Agents Phase 4
9 Clindamycin palmitate Phase 4
10 Clindamycin phosphate Phase 4
11
Amoxicillin Approved, Vet_approved 26787-78-0 33613
12 penicillins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Antibiotics During Intrauterine Balloon Tamponade Placement Recruiting NCT03478163 Phase 4 CeFAZolin 1000 MG;Clindamycin 900 MG in 6 ML Injection
2 Extended Open Challenge in Patients With a History of Drug Eruption Following Beta-lactam Treatment Completed NCT01520181 Beta-lactam oral challenge
3 The Optimized Diagnostic Methods for the Confirmation of Beta-lactam Hypersensitivity in Thailand Completed NCT01667055
4 Point of Care Group A Streptococcal Testing in a Pediatric Emergency Department: A Randomized Controlled Trial Recruiting NCT03744832

Search NIH Clinical Center for Beta-Lactam Allergy

Genetic Tests for Beta-Lactam Allergy

Anatomical Context for Beta-Lactam Allergy

MalaCards organs/tissues related to Beta-Lactam Allergy:

40
Testes, Skin, Lung, Heart, Kidney, Eye

Publications for Beta-Lactam Allergy

Articles related to Beta-Lactam Allergy:

(show top 50) (show all 107)
# Title Authors PMID Year
1
Self-reported beta-lactam allergy and the risk of surgical site infection: A retrospective cohort study. 61
31969205 2020
2
The negative predictive value of 5-day drug provocation test in nonimmediate beta-lactam allergy in children. 61
31923549 2020
3
Polymorphisms in the interleukin 4 receptor and interleukin 13 genes in immediate allergic reactions to beta-lactam antibiotics: A case-control study. 61
30525746 2019
4
Impact of Beta-lactam Allergy on Treatment of Outpatient Infections. 61
31662217 2019
5
A Comprehensive Prospective Study of Costs Associated to the Evaluation of beta-lactam Allergy. 61
31599727 2019
6
Limited Utility of Prolonged Drug Provocations in Beta-Lactam Allergy: A Global Perspective. 61
31495428 2019
7
Identifying Low-Risk Beta-Lactam Allergy Patients in a UK Tertiary Centre. 61
30922992 2019
8
Atopy can be an interfering factor in genetic association studies of beta-lactam allergy. 61
31530517 2019
9
Immediate cephalosporin allergy. 61
30667130 2019
10
Beta-lactam allergy in Chinese patients and factors predicting genuine allergy. 61
31692961 2019
11
Impact of a Standardized Beta-Lactam Allergy Questionnaire on Aztreonam Use. 61
29466923 2019
12
Inappropriate Use of Aztreonam. 61
31714256 2019
13
The Basics of Penicillin Allergy: What A Clinician Should Know. 61
31319528 2019
14
Acute care beta-lactam allergy pathways: approaches and outcomes. 61
31009700 2019
15
Self-reported beta-lactam intolerance: not a class effect, dangerous to patients, and rarely allergy. 61
31067139 2019
16
Fosfomycin in the pediatric setting: Evidence and potential indications. 61
31131593 2019
17
Compliance Rate of Surgical Antimicrobial Prophylaxis and its Association with Knowledge of Guidelines Among Surgical Residents in a Tertiary Care Public Hospital of a Developing Country. 61
31367494 2019
18
Outcomes from an inpatient beta-lactam allergy guideline across a large US health system. 61
30915929 2019
19
The role of skin testing and extended antibiotic courses in assessment of children with penicillin allergy: An Australian experience. 61
30209846 2019
20
Confronting the Challenge of Beta-Lactam Allergies: A Quasi-Experimental Study Assessing Impact of Pharmacy-Led Interventions. 61
29162022 2019
21
Antibiotic Allergy in Children: More than Just a Label. 61
31394524 2019
22
Controversies in Drug Allergy: Drug Allergy Pathways. 61
30573422 2019
23
Controversies in Drug Allergy: Beta-Lactam Hypersensitivity Testing. 61
30245291 2019
24
Opportunities for antimicrobial stewardship in patients with acute bacterial skin and skin structure infections who are unsuitable for beta-lactam antibiotics: a multicenter prospective observational study. 61
30783523 2019
25
Appropriateness of Beta-Lactam Allergy Record Updates After an Allergy Service Consult. 61
30180773 2018
26
Hypersensitivity reactions to beta-lactams in children. 61
29870460 2018
27
Management of fever and neutropenia in children with cancer: A survey of Australian and New Zealand practice. 61
29655245 2018
28
The Impact of Reported Beta-Lactam Allergy in Hospitalized Patients With Hematologic Malignancies Requiring Antibiotics. 61
29346543 2018
29
Designing Predictive Models for Beta-Lactam Allergy Using the Drug Allergy and Hypersensitivity Database. 61
28739365 2018
30
Hospitalizations in Children with a Penicillin Allergy Label: An Assessment of Healthcare Impact. 61
29788022 2018
31
Evaluation of IFN-γ Enzyme-linked Immunospot Assay (ELISPOT) as a First-line Test in the Diagnosis of Non-Immediate Hypersensitivity to Amoxicillin and Penicillin. 61
29665345 2018
32
[Hypersensitivity reactions to beta-lactam antibiotics]. 61
28754229 2017
33
Screening for Beta-Lactam Allergy in Joint Arthroplasty Patients to Improve Surgical Prophylaxis Practice. 61
28236547 2017
34
Addressing Inpatient Beta-Lactam Allergies: A Multihospital Implementation. 61
28483315 2017
35
Extended use of perioperative antibiotics in head and neck microvascular reconstruction. 61
28139320 2017
36
Frequency and Risk Factors of Penicillin and Amoxicillin Allergy in Suspected Patients with Drug Allergy. 61
28112529 2017
37
Impact of a pharmacist-driven beta-lactam allergy interview on inpatient antimicrobial therapy: A pilot project. 61
27745795 2016
38
The revolving door: antibiotic allergy labelling in a tertiary care centre. 61
27530619 2016
39
Impact of Reported Beta-Lactam Allergy on Inpatient Outcomes: A Multicenter Prospective Cohort Study. 61
27402820 2016
40
Lack of uniformity in the investigation and management of suspected β-lactam allergy in children. 61
26920651 2016
41
Empiric systemic antibiotics for hospitalized patients with severe odontogenic infections. 61
27369813 2016
42
Effectiveness of sequential intravenous-to-oral antibiotic switch therapy in hospitalized patients with gram-positive infection: the SEQUENCE cohort study. 61
27180242 2016
43
Adverse Drug Reactions Associated with Ceftaroline Use: A 2-Center Retrospective Cohort. 61
27130709 2016
44
Identifying opportunities in EHR to improve the quality of antibiotic allergy data. 61
26554427 2016
45
Prediction of Fluoroquinolone Resistance in Gram-Negative Bacteria Causing Bloodstream Infections. 61
26833166 2016
46
Prevalence of beta-lactam allergy: a retrospective chart review of drug allergy assessment in a predominantly pediatric population. 61
27956906 2016
47
Documenting Penicillin Allergy: The Impact of Inconsistency. 61
26981866 2016
48
Case Study of Intrapartum Antibiotic Prophylaxis and Subsequent Postpartum Beta-Lactam Anaphylaxis. 61
26178331 2015
49
Diagnosis of allergy against beta-lactams in primary care: prevalence and diagnostic criteria. 61
25851993 2015
50
Improving the Effectiveness of Penicillin Allergy De-labeling. 61
25609352 2015

Variations for Beta-Lactam Allergy

Expression for Beta-Lactam Allergy

Search GEO for disease gene expression data for Beta-Lactam Allergy.

Pathways for Beta-Lactam Allergy

Pathways related to Beta-Lactam Allergy according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.86 STAT6 MS4A2 IL4R IL4 IL13 IL10
2
Show member pathways
13.51 IL4R IL4 IL21R IL13 IL10 IFNGR2
3
Show member pathways
13.37 STAT6 IL4R IL4 IL13 IL10 IFNGR2
4
Show member pathways
13.14 STAT6 IL4R IL4 IL13 IL10 IGHE
5 12.66 STAT6 IL4R IL4 IL13 IFNGR2 IFNGR1
6
Show member pathways
12.61 STAT6 IL4R IL4 IL21R
7
Show member pathways
12.51 MS4A2 IL4R IL4 IL10 IGHE IFNGR2
8
Show member pathways
12.45 IL4 IL10 IFNGR2 IFNGR1
9
Show member pathways
12.43 MS4A2 IL4 IL13 IGHE
10 12.41 STAT6 IL4 IL10 ENPP3
11
Show member pathways
12.24 STAT6 IL4R IL4 IGHE
12
Show member pathways
12.11 IL4 IL10 IFNGR2 IFNGR1
13
Show member pathways
12.1 STAT6 IL4R IL4 IL21R IL13 IL10
14
Show member pathways
12.02 IL4 IFNGR2 IFNGR1
15
Show member pathways
11.93 IL21R IL10 IFNGR2 IFNGR1
16
Show member pathways
11.83 STAT6 IL4 ETV5
17 11.74 STAT6 IL4R IL21R IL10 IFNGR2 IFNGR1
18 11.69 STAT6 IL4R IL4 IL13 IL10 IGHE
19 11.66 IL4 IL13 IL10
20 11.59 IL4 IL13 IL10
21
Show member pathways
11.59 STAT6 IL4R IL4 IL21R IL13 IL10
22 11.57 STAT6 IL4R IL4 IL10 IGHE
23 11.45 IL4R IL21R IL10
24 11.39 IL4 IL13 IL10
25 11.32 STAT6 IL4R IL4 IL13 IL10
26 11.13 IL4 IL13 IL10
27 11.07 IL4 IL13 IL10

GO Terms for Beta-Lactam Allergy

Cellular components related to Beta-Lactam Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 MS4A2 IL13 IGHE ENPP3

Biological processes related to Beta-Lactam Allergy according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 defense response to protozoan GO:0042832 9.57 IL4R IL10
2 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.56 IFNGR2 IFNGR1
3 positive regulation of cold-induced thermogenesis GO:0120162 9.56 STAT6 IL4R IL4 IL13
4 positive regulation of MHC class II biosynthetic process GO:0045348 9.55 IL4 IL10
5 positive regulation of mast cell degranulation GO:0043306 9.54 IL4R IL13
6 negative regulation of endothelial cell apoptotic process GO:2000352 9.54 IL4 IL13 IL10
7 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.52 IL4 IL10
8 positive regulation of immunoglobulin production GO:0002639 9.51 IL4R IL13
9 microglial cell activation GO:0001774 9.5 IL13 IFNGR2 IFNGR1
10 immune response GO:0006955 9.5 MS4A2 IL4R IL4 IL13 IL10 IGHE
11 type 2 immune response GO:0042092 9.49 IL4 IL10
12 regulation of isotype switching GO:0045191 9.48 IL4 IL10
13 interleukin-4-mediated signaling pathway GO:0035771 9.46 STAT6 IL4R
14 negative regulation of complement-dependent cytotoxicity GO:1903660 9.43 IL4 IL13
15 positive regulation of isotype switching to IgE isotypes GO:0048295 9.4 STAT6 IL4
16 positive regulation of macrophage activation GO:0043032 9.33 IL4R IL13 IL10
17 cytokine-mediated signaling pathway GO:0019221 9.23 STAT6 IL4R IL4 IL13 IL10 IGHE

Molecular functions related to Beta-Lactam Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interferon-gamma receptor activity GO:0004906 8.96 IFNGR2 IFNGR1
2 cytokine receptor activity GO:0004896 8.92 IL4R IL21R IFNGR2 IFNGR1

Sources for Beta-Lactam Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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