MCID: BTL002
MIFTS: 39

Beta-Lactam Allergy

Categories: Immune diseases

Aliases & Classifications for Beta-Lactam Allergy

MalaCards integrated aliases for Beta-Lactam Allergy:

Name: Beta-Lactam Allergy 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060519

Summaries for Beta-Lactam Allergy

Disease Ontology : 12 A drug allergy triggered by a beta-lactam.

MalaCards based summary : Beta-Lactam Allergy is related to penicillin allergy and allergic hypersensitivity disease. An important gene associated with Beta-Lactam Allergy is IL4R (Interleukin 4 Receptor), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Cefazolin and Clindamycin have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and kidney, and related phenotypes are hematopoietic system and endocrine/exocrine gland

Related Diseases for Beta-Lactam Allergy

Diseases related to Beta-Lactam Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)
# Related Disease Score Top Affiliating Genes
1 penicillin allergy 31.4 IL13 IL4 IL4R STAT6
2 allergic hypersensitivity disease 29.4 IL10 IL13 IL4 IL4R
3 benzylpenicillin allergy 11.5
4 amoxicillin allergy 11.5
5 piperacillin allergy 11.5
6 aztreonam allergy 11.5
7 meropenem allergy 11.5
8 drug allergy 10.3
9 pollen allergy 10.2 IL13 IL4R
10 ascaridiasis 10.2 IL10 IL13
11 trichuriasis 10.2 IL10 IL13
12 peanut allergy 10.2 IL10 IL13
13 radiculopathy 10.2 IL10 IL13
14 cystic fibrosis 10.1
15 neutropenia 10.1
16 hyper ige syndrome 10.0 IL4 IL4R
17 inflammatory bowel disease 4 10.0 IL13 IL4
18 angiostrongyliasis 10.0 IL13 IL4
19 latex allergy 10.0 IL13 IL4
20 chronic tic disorder 10.0 IL13 IL4
21 chronic conjunctivitis 10.0 IL13 IL4
22 conjunctivitis 10.0 IL13 IL4
23 eosinophilic gastritis 10.0 IL13 IL4
24 vernal keratoconjunctivitis 10.0 IL13 IL4
25 keratoconjunctivitis 10.0 IL13 IL4
26 lipoid nephrosis 10.0 IL10 IL13 IL4R
27 enterobiasis 10.0 IL13 IL4
28 conjunctival disease 10.0 IL13 IL4
29 pulmonary eosinophilia 10.0 IL13 IL4
30 allergic contact dermatitis 10.0 IL10 IL4
31 contact dermatitis 10.0 IL10 IL4
32 onchocerciasis 10.0 IL13 IL4
33 allergic conjunctivitis 10.0 IL13 IL4
34 tropical endomyocardial fibrosis 10.0 IL10 IL4
35 endomyocardial fibrosis 10.0 IL10 IL4
36 hyperlucent lung 10.0 IL10 IL4
37 tungiasis 10.0 IL10 IL4
38 retinitis pigmentosa 22 10.0 IL10 IL4
39 baylisascariasis 10.0 IL10 IL4
40 gaucher disease, type ii 9.9 IL10 IL4
41 autoimmune gastritis 9.9 IL10 IL4
42 filarial elephantiasis 9.9 IL10 IL4
43 orofacial granulomatosis 9.9 IL10 IL4
44 buruli ulcer 9.9 IL10 IL4
45 bardet-biedl syndrome 15 9.9 IL10 IL4
46 primary systemic mycosis 9.9 IL10 IL4
47 poliomyelitis 9.9 IL10 IL4
48 eales disease 9.9 IL10 IL4
49 coccidiosis 9.9 IL10 IL4
50 milk allergy 9.9 IL10 IL4

Graphical network of the top 20 diseases related to Beta-Lactam Allergy:



Diseases related to Beta-Lactam Allergy

Symptoms & Phenotypes for Beta-Lactam Allergy

MGI Mouse Phenotypes related to Beta-Lactam Allergy:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.87 IFNGR2 IL10 IL13 IL21R IL4 IL4R
2 endocrine/exocrine gland MP:0005379 9.85 IL10 IL13 IL21R IL4 IL4R STAT6
3 homeostasis/metabolism MP:0005376 9.8 IFNGR2 IL10 IL13 IL21R IL4 IL4R
4 immune system MP:0005387 9.7 IFNGR2 IL10 IL13 IL21R IL4 IL4R
5 integument MP:0010771 9.35 IL10 IL13 IL4 IL4R STAT6
6 respiratory system MP:0005388 9.02 IL10 IL13 IL4 IL4R STAT6

Drugs & Therapeutics for Beta-Lactam Allergy

Drugs for Beta-Lactam Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cefazolin Approved Phase 4,Not Applicable 25953-19-9 33255 656510
2
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
3 Antibiotics, Antitubercular Phase 4,Not Applicable
4 Antitubercular Agents Phase 4,Not Applicable
5 Lactams Phase 4,Not Applicable
6 Anti-Infective Agents Phase 4,Not Applicable
7 Anti-Bacterial Agents Phase 4,Not Applicable
8 beta-Lactams Phase 4,Not Applicable
9 Clindamycin phosphate Phase 4
10 Clindamycin palmitate Phase 4
11
Amoxicillin Approved, Vet_approved Not Applicable 26787-78-0 33613
12 penicillins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Antibiotics During Intrauterine Balloon Tamponade Placement Recruiting NCT03478163 Phase 4 CeFAZolin 1000 MG;Clindamycin 900 MG in 6 ML Injection
2 Genomic Study of Genetic Polymorphisms Involved in Immediate Allergic Reactions to Beta-lactam Antibiotics Unknown status NCT02895646
3 Extended Open Challenge in Patients With a History of Drug Eruption Following Beta-lactam Treatment Completed NCT01520181 Not Applicable Beta-lactam oral challenge
4 Predictive Models for Betalactam Allergy Completed NCT03076749
5 Pharmacokinetics of Bolus Versus Continuous Cefazolin Infusion in Patients Undergoing Major Surgery Completed NCT02058979 Not Applicable BOLUS INFUSION (Ancef);CONTINUOUS INFUSION (Ancef)
6 The Diagnosis of Penicillin/Aminopenicillin Allergy in Thailand Completed NCT01667055

Search NIH Clinical Center for Beta-Lactam Allergy

Genetic Tests for Beta-Lactam Allergy

Anatomical Context for Beta-Lactam Allergy

MalaCards organs/tissues related to Beta-Lactam Allergy:

42
Skin, Testes, Kidney, Lung, Bone, Heart

Publications for Beta-Lactam Allergy

Articles related to Beta-Lactam Allergy:

(show top 50) (show all 54)
# Title Authors Year
1
The Importance of Delabeling β-Lactam Allergy in Children. ( 30322703 )
2019
2
Suspected Reaction with Cephalosporin May Be a Predictive Factor for β-Lactam Allergy in Children. ( 30517941 )
2019
3
A EAACI drug allergy interest group survey on how European allergy specialists deal with β-lactam allergy. ( 30637768 )
2019
4
Pharmacy-Led β-Lactam Allergy Interview (BLAI) Reduces Duration of Fluoroquinolones Within a Community Hospital. ( 30688514 )
2019
5
Outcomes from an inpatient beta-lactam allergy guideline across a large US health system. ( 30915929 )
2019
6
Identifying Low-Risk Beta-Lactam Allergy Patients in a UK Tertiary Centre. ( 30922992 )
2019
7
Impact of Reported β-Lactam Allergy on Management of Methicillin-Sensitive Staphylococcus aureus Bloodstream Infections. ( 30991876 )
2019
8
β-Lactam Allergy in the Operating Theater: Comment. ( 30994560 )
2019
9
β-Lactam Allergy in the Operating Theater: Comment. ( 30994561 )
2019
10
β-Lactam Allergy in the Operating Theater: Reply. ( 30994562 )
2019
11
Acute Care Beta-Lactam Allergy Pathways: Approaches and Outcomes. ( 31009700 )
2019
12
Designing Predictive Models for Beta-Lactam Allergy Using the Drug Allergy and Hypersensitivity Database. ( 28739365 )
2018
13
Cross-reactivity in β-Lactam Allergy. ( 29017833 )
2018
14
The Impact of Reported Beta-Lactam Allergy in Hospitalized Patients With Hematologic Malignancies Requiring Antibiotics. ( 29346543 )
2018
15
Impact of a Standardized Beta-Lactam Allergy Questionnaire on Aztreonam Use. ( 29466923 )
2018
16
De-labeling of β-lactam allergy reduces intraoperative time and optimizes choice in antibiotic prophylaxis. ( 29751965 )
2018
17
β-Lactam allergy de-labelling. ( 29756369 )
2018
18
Presumed β-Lactam Allergy and Cross-reactivity in the Operating Theater: A Practical Approach. ( 29762180 )
2018
19
Appropriateness of Beta-Lactam Allergy Record Updates After an Allergy Service Consult. ( 30180773 )
2018
20
Screening for Beta-Lactam Allergy in Joint Arthroplasty Patients to Improve Surgical Prophylaxis Practice. ( 28236547 )
2017
21
Point-of-Care β-Lactam Allergy Skin Testing by Antimicrobial Stewardship Programs: A Pragmatic Multicenter Prospective Evaluation. ( 28575226 )
2017
22
Optimizing preoperative prophylaxis in patients with reported β-lactam allergy: a novel extension of antimicrobial stewardship. ( 28605452 )
2017
23
Using β-lactam antibiotics in patients with a history of β-lactam allergy: current concepts. ( 28724882 )
2017
24
Impact of an antimicrobial stewardship initiative to evaluate β-lactam allergy in patients ordered aztreonam. ( 26896530 )
2016
25
Lack of uniformity in the investigation and management of suspected β-lactam allergy in children. ( 26920651 )
2016
26
Impact of Reported Beta-Lactam Allergy on Inpatient Outcomes: A Multicenter Prospective Cohort Study. ( 27402820 )
2016
27
Impact of a pharmacist-driven beta-lactam allergy interview on inpatient antimicrobial therapy: A pilot project. ( 27745795 )
2016
28
Prevalence of beta-lactam allergy: a retrospective chart review of drug allergy assessment in a predominantly pediatric population. ( 27956906 )
2016
29
Correlation analysis of gene polymorphisms and β-lactam allergy. ( 26160721 )
2015
30
Aztreonam for febrile neutropenia in patients with beta-lactam allergy. ( 24119095 )
2014
31
Penicillin and beta-lactam allergy: epidemiology and diagnosis. ( 25216741 )
2014
32
Optimizing empiric antibiotic therapy in patients with severe β-lactam allergy. ( 24041892 )
2013
33
β-lactam allergy: clinical implications and costs. ( 24283514 )
2013
34
Evaluating the usefulness of retesting for beta-lactam allergy in children. ( 22673138 )
2012
35
Tigecycline use in patient with intra-abdominal abscess, beta-lactam allergy, and acute kidney injury. ( 23039235 )
2012
36
Retesting in children with β-lactam allergy. ( 21596422 )
2011
37
Educational case series: β-lactam allergy and cross-reactivity. ( 21929594 )
2011
38
Beta lactam allergy in children from two ethnically different populations. ( 19549064 )
2010
39
Gene variants of IL13, IL4, and IL4RA are predictors of beta-lactam allergy. ( 19121856 )
2009
40
Beta lactam allergy and resensitization in children with suspected beta lactam allergy. ( 19178535 )
2009
41
Diagnosis of immediate-type beta-lactam allergy in vitro by flow-cytometric basophil activation test and sulfidoleukotriene production: a multicenter study. ( 19476013 )
2009
42
Relevance of the determination of serum-specific IgE antibodies in the diagnosis of immediate beta-lactam allergy. ( 17156341 )
2007
43
Beta-lactam allergy in adults with cystic fibrosis. ( 17182289 )
2007
44
Penicillin skin testing in patients with a history of beta-lactam allergy. ( 17458432 )
2007
45
Assessment of a new brand of determinants for skin testing in a large group of patients with suspected beta-lactam allergy. ( 17694698 )
2007
46
Beta-lactam allergy in children. ( 16672016 )
2006
47
IL-10 promoter and IL4-Ralpha gene SNPs are associated with immediate beta-lactam allergy in atopic women. ( 16867043 )
2006
48
Authors reply to beta-lactam allergy in children. ( 17121594 )
2006
49
Update on beta-lactam allergy diagnosis. ( 15659257 )
2005
50
Importance of mixture of minor determinants and benzylpenicilloyl poly-L-lysine skin testing in the diagnosis of beta-lactam allergy. ( 15940154 )
2005

Variations for Beta-Lactam Allergy

Expression for Beta-Lactam Allergy

Search GEO for disease gene expression data for Beta-Lactam Allergy.

Pathways for Beta-Lactam Allergy

Pathways related to Beta-Lactam Allergy according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.71 IFNGR2 IL10 IL13 IL4 IL4R STAT6
2
Show member pathways
13.4 IFNGR2 IL10 IL13 IL21R IL4 IL4R
3
Show member pathways
13.26 IFNGR2 IL10 IL13 IL4 IL4R STAT6
4
Show member pathways
13.15 IL10 IL13 IL4 IL4R STAT6
5
Show member pathways
13.08 IFNGR2 IL10 IL13 IL4 IL4R STAT6
6
Show member pathways
13.03 IL10 IL13 IL4 IL4R
7
Show member pathways
12.94 IFNGR2 IL4 IL4R STAT6
8
Show member pathways
12.65 IFNGR2 IL10 IL13 IL4 IL4R
9 12.6 IFNGR2 IL13 IL4 IL4R STAT6
10
Show member pathways
12.57 IL21R IL4 IL4R STAT6
11
Show member pathways
12.43 IFNGR2 IL10 IL4 IL4R
12 12.33 IL10 IL4 STAT6
13
Show member pathways
12.18 IL4 IL4R STAT6
14
Show member pathways
12.06 IFNGR2 IL10 IL4
15
Show member pathways
12.04 IFNGR2 IL10 IL13 IL21R IL4 IL4R
16
Show member pathways
12.03 IL10 IL13 IL4
17
Show member pathways
11.89 IFNGR2 IL10 IL21R
18
Show member pathways
11.81 IFNGR2 IL10 IL13 IL4 IL4R
19 11.71 IL10 IL13 IL4 IL4R STAT6
20 11.66 IFNGR2 IL10 IL21R IL4R STAT6
21 11.65 IL10 IL13 IL4
22 11.59 IL10 IL13 IL4
23
Show member pathways
11.53 IFNGR2 IL10 IL13 IL21R IL4 IL4R
24 11.47 IL10 IL4 IL4R STAT6
25 11.45 IL13 IL4
26 11.44 IL10 IL21R IL4R
27 11.39 IL10 IL13 IL4
28 11.22 IL10 IL13 IL4 IL4R STAT6
29 11.15 IL4 IL4R
30 11.13 IL13 IL4
31 11.1 IL10 IL13 IL4
32 11.02 IL10 IL13 IL4
33 11.02 IL10 IL13 IL4

GO Terms for Beta-Lactam Allergy

Biological processes related to Beta-Lactam Allergy according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.83 IL10 IL13 IL4 IL4R
2 regulation of signaling receptor activity GO:0010469 9.75 IL10 IL13 IL4
3 B cell differentiation GO:0030183 9.57 IL10 IL4
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.56 IL13 IL4
5 positive regulation of B cell proliferation GO:0030890 9.55 IL13 IL4
6 defense response to protozoan GO:0042832 9.54 IL10 IL4R
7 positive regulation of mast cell degranulation GO:0043306 9.51 IL13 IL4R
8 positive regulation of immunoglobulin production GO:0002639 9.49 IL13 IL4R
9 positive regulation of MHC class II biosynthetic process GO:0045348 9.48 IL10 IL4
10 interleukin-4-mediated signaling pathway GO:0035771 9.46 IL4R STAT6
11 regulation of isotype switching GO:0045191 9.43 IL10 IL4
12 negative regulation of endothelial cell apoptotic process GO:2000352 9.43 IL10 IL13 IL4
13 type 2 immune response GO:0042092 9.4 IL10 IL4
14 negative regulation of complement-dependent cytotoxicity GO:1903660 9.37 IL13 IL4
15 positive regulation of macrophage activation GO:0043032 9.33 IL10 IL13 IL4R
16 positive regulation of isotype switching to IgE isotypes GO:0048295 9.32 IL4 STAT6
17 positive regulation of cold-induced thermogenesis GO:0120162 9.26 IL13 IL4 IL4R STAT6
18 cytokine-mediated signaling pathway GO:0019221 9.1 IFNGR2 IL10 IL13 IL4 IL4R STAT6

Molecular functions related to Beta-Lactam Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine receptor activity GO:0004896 9.16 IL21R IL4R
2 cytokine receptor binding GO:0005126 8.96 IL13 IL4
3 cytokine activity GO:0005125 8.8 IL10 IL13 IL4

Sources for Beta-Lactam Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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