MCID: BTL002
MIFTS: 35

Beta-Lactam Allergy

Categories: Immune diseases

Aliases & Classifications for Beta-Lactam Allergy

MalaCards integrated aliases for Beta-Lactam Allergy:

Name: Beta-Lactam Allergy 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060519

Summaries for Beta-Lactam Allergy

Disease Ontology : 12 A drug allergy triggered by a beta-lactam.

MalaCards based summary : Beta-Lactam Allergy is related to amoxicillin allergy and allergic hypersensitivity disease. An important gene associated with Beta-Lactam Allergy is IL4R (Interleukin 4 Receptor), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs Cefazolin and Clindamycin have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and heart, and related phenotypes are cellular and endocrine/exocrine gland

Related Diseases for Beta-Lactam Allergy

Diseases related to Beta-Lactam Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 154)
# Related Disease Score Top Affiliating Genes
1 amoxicillin allergy 32.2 MARCHF7 IGHE
2 allergic hypersensitivity disease 30.3 IL4R IL4 IL13 IL10 IGHE
3 otitis media 30.3 IL4 IL13 IL10 IGHE
4 drug allergy 30.2 IL4R IGHE ETV5 ATP12A
5 urticaria 30.1 IL4 IL13 IL10 IGHE
6 penicillin allergy 30.0 STAT6 KAT8 IL4R IL4 IL13 IL10
7 hypereosinophilic syndrome 29.7 IL4 IL13 IL10 IGHE IGES
8 ige responsiveness, atopic 28.3 STAT6 MS4A2 IL4R IL4 IL21R IL13
9 benzylpenicillin allergy 11.6
10 piperacillin allergy 11.6
11 aztreonam allergy 11.6
12 meropenem allergy 11.6
13 tropical endomyocardial fibrosis 10.4 IL4 IL10
14 endomyocardial fibrosis 10.4 IL4 IL10
15 carbapenem allergy 10.4 STAT6 IL13
16 jak3-deficient severe combined immunodeficiency 10.4 STAT6 IL4
17 autoimmune hepatitis type 1 10.4 IL4 IL10
18 metal allergy 10.4 IL4 IL10
19 orofacial granulomatosis 10.4 IL4 IL10
20 eales disease 10.3 IL4 IL10
21 exanthem 10.3
22 nickel allergic contact dermatitis 10.3 IL4 IL10
23 axillary adenitis 10.3 IFNGR2 IFNGR1
24 angiostrongyliasis 10.3 IL4 IL13
25 low-grade astrocytoma 10.3 STAT6 IL13
26 atopic keratoconjunctivitis 10.3 IL4 IGHE
27 idiopathic nephrotic syndrome 10.3 IL4 IGHE
28 esophagitis 10.3 IL4 IL13 IL10
29 idiopathic interstitial pneumonia 10.3 IL4R IL4 IL13
30 loiasis 10.3 IL4 IL13 IL10
31 mikulicz disease 10.3 IL4 IL13 IL10
32 trichinosis 10.3 IL4 IL13 IL10
33 dacryoadenitis 10.3 IL4 IL13 IL10
34 elephantiasis 10.3 IL4 IL13 IL10
35 mucocutaneous leishmaniasis 10.3 IL4 IL13 IL10
36 lipoid nephrosis 10.3 IL4R IL13 IL10
37 cutaneous leishmaniasis 10.3 IL4 IL13 IL10
38 toxic oil syndrome 10.3 IL4 IGHE
39 eosinophilic meningitis 10.3 IL4 IL13 IL10
40 meningitis 10.3 IL4 IL13 IL10
41 legume allergy 10.3 IL4 IL13 IL10
42 fruit allergy 10.3 IL4 IL13 IL10
43 filarial elephantiasis 10.3 IL4 IL13 IL10
44 intestinal schistosomiasis 10.3 IL4 IL13 IL10
45 african tick-bite fever 10.3 IL13 IL10
46 cryptococcosis 10.3 IL4 IL13 IL10
47 mycoplasma pneumoniae pneumonia 10.3 IL4 IL13 IL10
48 conjunctival disease 10.3 IL4 IL13 IL10
49 cephalosporin allergy 10.3
50 acute cystitis 10.3

Graphical network of the top 20 diseases related to Beta-Lactam Allergy:



Diseases related to Beta-Lactam Allergy

Symptoms & Phenotypes for Beta-Lactam Allergy

MGI Mouse Phenotypes related to Beta-Lactam Allergy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.97 ETV5 IFNGR1 IFNGR2 IL10 IL13 IL4
2 endocrine/exocrine gland MP:0005379 9.86 ETV5 IFNGR1 IL10 IL13 IL21R IL4
3 hematopoietic system MP:0005397 9.85 IFNGR1 IFNGR2 IL10 IL13 IL21R IL4
4 homeostasis/metabolism MP:0005376 9.7 ATP12A IFNGR1 IFNGR2 IL10 IL13 IL21R
5 immune system MP:0005387 9.32 IFNGR1 IFNGR2 IL10 IL13 IL21R IL4

Drugs & Therapeutics for Beta-Lactam Allergy

Drugs for Beta-Lactam Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cefazolin Approved Phase 4 25953-19-9 656510 33255
2
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
3
Vancomycin Approved Phase 4 1404-90-6 14969 441141
4 Clindamycin phosphate Phase 4
5 Clindamycin palmitate Phase 4
6 Anti-Bacterial Agents Phase 4
7 Lactams Phase 4
8 beta-Lactams Phase 4
9 Anti-Infective Agents Phase 4
10 Cephalosporins Phase 4
11 Anesthetics Phase 4
12 Antibiotics, Antitubercular Phase 4
13
Amikacin Approved, Investigational, Vet_approved Phase 2 37517-28-5 37768
14
Fosfomycin Approved Phase 2 23155-02-4 446987
15
Amoxicillin Approved, Vet_approved 26787-78-0 33613
16 penicillins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Antibiotics During Intrauterine Balloon Tamponade Placement Recruiting NCT03478163 Phase 4 CeFAZolin 1000 MG;Clindamycin 900 MG in 6 ML Injection
2 First Tier Versus Second Tier Antibiotics for Surgical Site Infections Following Hysterectomy In the Patients With a Beta-Lactam Allergy: A Prospective, Randomized, Single-Blinded Clinical Trial Not yet recruiting NCT04401553 Phase 4 cephalosporin;Second tier antibiotic (Vancomycin)
3 Randomized Phase II Study of Antibiotic Prophylaxis With Fosfomycin vs Amikacin in Transurethral Resection of Bladder Recruiting NCT04209192 Phase 2 Fosfomycin Tromethamine 3G Sachet;Amikacin
4 Extended Open Challenge in Patients With a History of Drug Eruption Following Beta-lactam Treatment Completed NCT01520181 Beta-lactam oral challenge
5 The Optimized Diagnostic Methods for the Confirmation of Beta-lactam Hypersensitivity in Thailand Completed NCT01667055
6 Point of Care Group A Streptococcal Testing in a Pediatric Emergency Department: A Randomized Controlled Trial Recruiting NCT03744832

Search NIH Clinical Center for Beta-Lactam Allergy

Genetic Tests for Beta-Lactam Allergy

Anatomical Context for Beta-Lactam Allergy

MalaCards organs/tissues related to Beta-Lactam Allergy:

40
Testes, Skin, Heart, Kidney, Liver

Publications for Beta-Lactam Allergy

Articles related to Beta-Lactam Allergy:

(show top 50) (show all 113)
# Title Authors PMID Year
1
Appropriateness of Beta-Lactam Allergy Record Updates After an Allergy Service Consult. 61
30180773 2020
2
The Effect of Beta-lactam Allergy Status on the Rate of Surgical Site Infections: A Retrospective Cohort Study. 61
32502079 2020
3
The negative predictive value of 5-day drug provocation test in nonimmediate beta-lactam allergy in children. 61
31923549 2020
4
Impact of Allergy Clarification for Cefazolin Evidence-based Prescribing Tool (ACCEPT) on Receipt of Preferred Perioperative Prophylaxis: An Interrupted Time Series Study. 61
32364587 2020
5
The use of in vivo and in vitro tests in children with beta lactam allergy. 61
32473813 2020
6
What is the Primary Driver of Pre-Operative Vancomycin Use? It's Not MRSA-or Allergy. 61
32337589 2020
7
Impact of beta-lactam allergy label in liver transplant recipients. 61
32304837 2020
8
Impact of an antibiotic side chain-based cross-reactivity chart combined with enhanced allergy assessment processes for surgical prophylaxis antimicrobials in patients with beta-lactam allergies. 61
32155264 2020
9
Beta-lactam allergy in the paediatric population. 61
32042244 2020
10
Self-reported beta-lactam allergy and the risk of surgical site infection: A retrospective cohort study. 61
31969205 2020
11
Impact of Beta-lactam Allergy on Treatment of Outpatient Infections. 61
31662217 2019
12
Polymorphisms in the interleukin 4 receptor and interleukin 13 genes in immediate allergic reactions to beta-lactam antibiotics: A case-control study. 61
30525746 2019
13
A Comprehensive Prospective Study of Costs Associated to the Evaluation of beta-lactam Allergy. 61
31599727 2019
14
Identifying Low-Risk Beta-Lactam Allergy Patients in a UK Tertiary Centre. 61
30922992 2019
15
Limited Utility of Prolonged Drug Provocations in Beta-Lactam Allergy: A Global Perspective. 61
31495428 2019
16
Impact of a Standardized Beta-Lactam Allergy Questionnaire on Aztreonam Use. 61
29466923 2019
17
Immediate cephalosporin allergy. 61
30667130 2019
18
Beta-lactam allergy in Chinese patients and factors predicting genuine allergy. 61
31692961 2019
19
Inappropriate Use of Aztreonam. 61
31714256 2019
20
The Basics of Penicillin Allergy: What A Clinician Should Know. 61
31319528 2019
21
Acute care beta-lactam allergy pathways: approaches and outcomes. 61
31009700 2019
22
Self-reported beta-lactam intolerance: not a class effect, dangerous to patients, and rarely allergy. 61
31067139 2019
23
Fosfomycin in the pediatric setting: Evidence and potential indications. 61
31131593 2019
24
Compliance Rate of Surgical Antimicrobial Prophylaxis and its Association with Knowledge of Guidelines Among Surgical Residents in a Tertiary Care Public Hospital of a Developing Country. 61
31367494 2019
25
Outcomes from an inpatient beta-lactam allergy guideline across a large US health system. 61
30915929 2019
26
The role of skin testing and extended antibiotic courses in assessment of children with penicillin allergy: An Australian experience. 61
30209846 2019
27
Confronting the Challenge of Beta-Lactam Allergies: A Quasi-Experimental Study Assessing Impact of Pharmacy-Led Interventions. 61
29162022 2019
28
Antibiotic Allergy in Children: More than Just a Label. 61
31394524 2019
29
Opportunities for antimicrobial stewardship in patients with acute bacterial skin and skin structure infections who are unsuitable for beta-lactam antibiotics: a multicenter prospective observational study. 61
30783523 2019
30
Controversies in Drug Allergy: Drug Allergy Pathways. 61
30573422 2019
31
Controversies in Drug Allergy: Beta-Lactam Hypersensitivity Testing. 61
30245291 2019
32
Hypersensitivity reactions to beta-lactams in children. 61
29870460 2018
33
Management of fever and neutropenia in children with cancer: A survey of Australian and New Zealand practice. 61
29655245 2018
34
The Impact of Reported Beta-Lactam Allergy in Hospitalized Patients With Hematologic Malignancies Requiring Antibiotics. 61
29346543 2018
35
Designing Predictive Models for Beta-Lactam Allergy Using the Drug Allergy and Hypersensitivity Database. 61
28739365 2018
36
Hospitalizations in Children with a Penicillin Allergy Label: An Assessment of Healthcare Impact. 61
29788022 2018
37
Evaluation of IFN-γ Enzyme-linked Immunospot Assay (ELISPOT) as a First-line Test in the Diagnosis of Non-Immediate Hypersensitivity to Amoxicillin and Penicillin. 61
29665345 2018
38
[Hypersensitivity reactions to beta-lactam antibiotics]. 61
28754229 2017
39
Screening for Beta-Lactam Allergy in Joint Arthroplasty Patients to Improve Surgical Prophylaxis Practice. 61
28236547 2017
40
Addressing Inpatient Beta-Lactam Allergies: A Multihospital Implementation. 61
28483315 2017
41
Extended use of perioperative antibiotics in head and neck microvascular reconstruction. 61
28139320 2017
42
Frequency and Risk Factors of Penicillin and Amoxicillin Allergy in Suspected Patients with Drug Allergy. 61
28112529 2017
43
Impact of a pharmacist-driven beta-lactam allergy interview on inpatient antimicrobial therapy: A pilot project. 61
27745795 2016
44
The revolving door: antibiotic allergy labelling in a tertiary care centre. 61
27530619 2016
45
Impact of Reported Beta-Lactam Allergy on Inpatient Outcomes: A Multicenter Prospective Cohort Study. 61
27402820 2016
46
Empiric systemic antibiotics for hospitalized patients with severe odontogenic infections. 61
27369813 2016
47
Lack of uniformity in the investigation and management of suspected β-lactam allergy in children. 61
26920651 2016
48
Effectiveness of sequential intravenous-to-oral antibiotic switch therapy in hospitalized patients with gram-positive infection: the SEQUENCE cohort study. 61
27180242 2016
49
Adverse Drug Reactions Associated with Ceftaroline Use: A 2-Center Retrospective Cohort. 61
27130709 2016
50
Identifying opportunities in EHR to improve the quality of antibiotic allergy data. 61
26554427 2016

Variations for Beta-Lactam Allergy

Expression for Beta-Lactam Allergy

Search GEO for disease gene expression data for Beta-Lactam Allergy.

Pathways for Beta-Lactam Allergy

Pathways related to Beta-Lactam Allergy according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.86 STAT6 MS4A2 IL4R IL4 IL13 IL10
2
Show member pathways
13.37 STAT6 IL4R IL4 IL13 IL10 IFNGR2
3
Show member pathways
13.19 STAT6 IL4R IL4 IL13 IL10 IGHE
4 12.7 STAT6 IL4R IL4 IL13 IFNGR2 IFNGR1
5
Show member pathways
12.51 MS4A2 IL4R IL4 IL10 IGHE IFNGR2
6
Show member pathways
12.45 IL4 IL10 IFNGR2 IFNGR1
7
Show member pathways
12.43 MS4A2 IL4 IL13 IGHE
8
Show member pathways
12.24 STAT6 IL4R IL4 IGHE
9
Show member pathways
12.13 IL4 IL10 IFNGR2 IFNGR1
10
Show member pathways
11.99 STAT6 IL4R IL4 IL21R
11
Show member pathways
11.96 STAT6 IL4R IL4 IL21R IL13 IL10
12
Show member pathways
11.83 STAT6 IL4 ETV5
13
Show member pathways
11.79 IL10 IFNGR2 IFNGR1
14
Show member pathways
11.76 STAT6 IL4R IL4 IL21R IL13 IL10
15
Show member pathways
11.71 IL4R IL4 IL21R
16 11.69 STAT6 IL4R IL4 IL13 IL10 IGHE
17 11.65 IL4 IL13 IL10
18 11.52 STAT6 IL4R IL4 IL10 IGHE
19 11.4 IL4 IL13 IL10
20 11.32 STAT6 IL4R IL4 IL13 IL10
21 11.16 IL4 IL13 IL10
22 11.1 IL4 IL13 IL10
23 10.9 STAT6 IL4R IL4 IL21R
24 10.69 IL4R IL4 IL13

GO Terms for Beta-Lactam Allergy

Biological processes related to Beta-Lactam Allergy according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.8 MS4A2 IL4R IL4 IL13 IL10 IGHE
2 negative regulation of inflammatory response GO:0050728 9.77 IL4 IL13 IL10
3 positive regulation of cold-induced thermogenesis GO:0120162 9.67 STAT6 IL4R IL4 IL13
4 positive regulation of myoblast fusion GO:1901741 9.58 IL4R IL4
5 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.58 IFNGR2 IFNGR1
6 negative regulation of endothelial cell apoptotic process GO:2000352 9.58 IL4 IL13 IL10
7 macrophage activation GO:0042116 9.57 IL4 IL13
8 positive regulation of interleukin-10 secretion GO:2001181 9.56 IL4 IL13
9 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.55 IL4 IL10
10 positive regulation of MHC class II biosynthetic process GO:0045348 9.54 IL4 IL10
11 positive regulation of immunoglobulin production GO:0002639 9.52 IL4R IL13
12 type 2 immune response GO:0042092 9.51 IL4 IL10
13 regulation of isotype switching GO:0045191 9.49 IL4 IL10
14 interleukin-4-mediated signaling pathway GO:0035771 9.48 STAT6 IL4R
15 negative regulation of complement-dependent cytotoxicity GO:1903660 9.46 IL4 IL13
16 positive regulation of isotype switching to IgE isotypes GO:0048295 9.43 STAT6 IL4
17 positive regulation of macrophage activation GO:0043032 9.43 IL4R IL13 IL10
18 positive regulation of mast cell degranulation GO:0043306 9.33 IL4R IL4 IL13
19 microglial cell activation GO:0001774 9.26 IL4 IL13 IFNGR2 IFNGR1
20 cytokine-mediated signaling pathway GO:0019221 9.23 STAT6 IL4R IL4 IL13 IL10 IGHE

Molecular functions related to Beta-Lactam Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interferon-gamma receptor activity GO:0004906 8.96 IFNGR2 IFNGR1
2 cytokine receptor activity GO:0004896 8.92 IL4R IL21R IFNGR2 IFNGR1

Sources for Beta-Lactam Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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