MCID: BCR002
MIFTS: 24

Bicornuate Uterus

Categories: Fetal diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Bicornuate Uterus

MalaCards integrated aliases for Bicornuate Uterus:

Name: Bicornuate Uterus 58 29 54 6

Classifications:

Orphanet: 58  
Rare gynaecological and obstetric diseases
Developmental anomalies during embryogenesis


External Ids:

ICD10 via Orphanet 33 Q51.3
UMLS via Orphanet 72 C0266387
Orphanet 58 ORPHA180134

Summaries for Bicornuate Uterus

MalaCards based summary : Bicornuate Uterus is related to unicervical bicornuate uterus and bicervical bicornuate uterus and blind hemivagina. An important gene associated with Bicornuate Uterus is HNF1B (HNF1 Homeobox B). Affiliated tissues include uterus, cervix and kidney.

Wikipedia : 74 A bicornuate uterus or bicornate uterus (from the Latin cornū, meaning "horn"), is a type of mullerian... more...

Related Diseases for Bicornuate Uterus

Diseases related to Bicornuate Uterus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Related Disease Score Top Affiliating Genes
1 unicervical bicornuate uterus 12.6
2 bicervical bicornuate uterus and blind hemivagina 12.5
3 bicervical bicornuate uterus with patent cervix and vagina 12.5
4 didelphys uterus 11.8
5 renal cysts and diabetes syndrome 11.8
6 uterine anomalies 10.7
7 renal hypodysplasia/aplasia 1 10.7
8 infertility 10.6
9 endometrial cancer 10.5
10 ectopic pregnancy 10.5
11 septate uterus 10.5
12 hemometra 10.4
13 endometrial adenocarcinoma 10.4
14 uterine inversion 10.4
15 mayer-rokitansky-kuster-hauser syndrome 10.3
16 arteriovenous malformation 10.3
17 amenorrhea 10.3
18 transverse vaginal septum 10.3
19 renal dysplasia 10.3
20 cleft palate, isolated 10.1
21 diabetes mellitus, noninsulin-dependent 10.1
22 tracheoesophageal fistula with or without esophageal atresia 10.1
23 anencephaly 10.1
24 hydatidiform mole, recurrent, 1 10.1
25 exstrophy of bladder 10.1
26 adenomyosis 10.1
27 budd-chiari syndrome 10.1
28 cervical cancer 10.1
29 maturity-onset diabetes of the young 10.1
30 hyperprolactinemia 10.1
31 hepatocellular adenoma 10.1
32 pancreatic agenesis 10.1
33 scoliosis 10.1
34 omphalocele 10.1
35 endometrial hyperplasia 10.1
36 esophageal atresia 10.1
37 supine hypotensive syndrome 10.1
38 pre-eclampsia 10.1
39 meningocele 10.1
40 microcephaly 10.1
41 hydronephrosis 10.1
42 typhoid fever 10.1
43 eclampsia 10.1
44 vacterl association 10.1
45 leydig cell tumor 10.1
46 endometriosis 10.1
47 adenocarcinoma 10.1
48 sertoli-leydig cell tumor 10.1
49 teratoma 10.1
50 gestational trophoblastic neoplasm 10.1

Graphical network of the top 20 diseases related to Bicornuate Uterus:



Diseases related to Bicornuate Uterus

Symptoms & Phenotypes for Bicornuate Uterus

Drugs & Therapeutics for Bicornuate Uterus

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Sonographic Assessment of Myometrial Thickness as a Predictor for the Latency Interval in Women With Preterm Premature Rupture of Membranes Unknown status NCT02380560

Search NIH Clinical Center for Bicornuate Uterus

Genetic Tests for Bicornuate Uterus

Genetic tests related to Bicornuate Uterus:

# Genetic test Affiliating Genes
1 Bicornuate Uterus 29

Anatomical Context for Bicornuate Uterus

MalaCards organs/tissues related to Bicornuate Uterus:

40
Uterus, Cervix, Kidney, Placenta, Ovary, Brain, Heart

Publications for Bicornuate Uterus

Articles related to Bicornuate Uterus:

(show top 50) (show all 458)
# Title Authors PMID Year
1
Splice site mutation in the hepatocyte nuclear factor-1 beta gene, IVS2nt + 1G > A, associated with maturity-onset diabetes of the young, renal dysplasia and bicornuate uterus. 54 61
11317673 2001
2
Favorable pregnancy outcome for a patient with Robert's uterus, bicornuate uterus, and ipsilateral renal agenesis. 61
32542745 2020
3
Proposal of the 3O (Obstruction, Ureteric Orifice, and Outcome) Subclassification System Associated with Obstructed Hemivagina and Ipsilateral Renal Anomaly (OHVIRA). 61
31931122 2020
4
Persistent Breech Presentation In A Bicornuate Uterus. 61
32565237 2020
5
A case of MODY5-like manifestations without mutations or deletions in coding and minimal promoter regions of the HNF1B gene. 61
32461507 2020
6
Cervical length surveillance for predicting spontaneous preterm birth in women with uterine anomalies: A cohort study. 61
32438506 2020
7
Avoiding the fatal misdiagnosis of pregnancy in a noncommunicating rudimentary horn using 3D transvaginal ultrasound. 61
32255499 2020
8
Diagnosis and treatment of müllerian malformations. 61
32127135 2020
9
Inguinal herniation of left ovary, fallopian tube and rudimentary left horn of bicornuate uterus associated with type 2 Mayer-Rakitansky-Kuster-Hauser (MRKH) syndrome in a teenage girl: A case report and literature review. 61
32021881 2020
10
Unintended pregnancy with IUD in situ reveals the IUD placement into one of the uterine horns in a bicornuate uterus. 61
31796441 2019
11
Müllerian Anomalies Prevalence Diagnosed by Hysteroscopy and Laparoscopy in Mexican Infertile Women: Results from a Cohort Study. 61
31627332 2019
12
Currarino syndrome in an adult woman. 61
31538082 2019
13
Treatment of locally advanced cervical cancer in a patient with a bicornuate uterus with MRI-guided intracavitary/interstitial brachytherapy. 61
31435436 2019
14
Bicornuate Uterus with Complete Cervico-Vaginal Agenesis and Skeletal Deformity: A Case Report. 61
30956497 2019
15
Frequency and types of uterine anomalies during caesarean section. 61
30372654 2019
16
Successful delivery of spontaneously conceived twins in a single horn of a bicornuate uterus: A case report. 61
30886828 2019
17
Successful Management of Complicated Uterine Displacement Caused by Unilateral Incarceration of the Bicornuate Uterus. 61
30984434 2019
18
Congenital anal atresia with rectovestibular fistula, scoliosis, unilateral renal agenesis, and finger defect (VACTERL association) in a patient with partial bicornuate uterus and distal vaginal atresia: A case report. 61
30407282 2018
19
Modified ex utero intrapartum treatment procedure in a bicornuate uterus breech presentation Pierre Robin fetus with severe micrognathia and cleft palate. 61
30455887 2018
20
Rare cases of ectopic ureter: Analysis from a single centre with review of the literature. 61
30475701 2018
21
Uterine didelphys with one cervix obscured by blind hemivagina: a lesson in rarity. 61
30077979 2018
22
Obstetric outcome in patients with a unicornuate uterus after laparoscopic resection of a rudimentary horn. 61
29516633 2018
23
Endometrial carcinoma in a single horn of a bicornuate uterus: A case report. 61
29779939 2018
24
Are 3D ultrasound and office hysteroscopy useful for the assessment of uterine cavity after late foetal loss? 61
29475047 2018
25
Uterine torsion and subsequent rupture in a gravid bicornuate uterus associated with an elevated alpha-fetoprotein. 61
29804076 2018
26
Successful use of balloon tamponade in the management of postpartum hemorrhage in a case of bicornuate uterus. 61
29796270 2018
27
Bicornuate Bicollis Uterus with Obstruction of the Lower Uterine Segment and Cervical Prolapse Complicating Pregnancy. 61
30186650 2018
28
De novo HNF1 homeobox B mutation as a cause for chronic, treatment-resistant hypomagnesaemia. 61
29576871 2018
29
Successful Pregnancy Outcome after Open Strassman Metroplasty for Bicornuate Uterus. 61
30018833 2018
30
The spectrum of imaging appearances of müllerian duct anomalies: focus on MR imaging. 61
28921452 2017
31
Dietary management of maternal phenylketonuria with glycomacropeptide and amino acids supplements: A case report. 61
29085781 2017
32
Bicornuate uterus is an independent risk factor for cervical os insufficiency: A retrospective population based cohort study. 61
27903074 2017
33
Scar Endometriosis with Rudimentary Horn: An Unusual and Elucidative Report of a Case Diagnosed on Histopathology and Immunohistochemistry. 61
29307985 2017
34
Advanced abdominal pregnancy, with live fetus and severe preeclampsia, case report. 61
28747162 2017
35
Successful Reproductive Outcome After Laparoscopic Strassmann's Metroplasty. 61
29142454 2017
36
Uterine rupture in a primigravid patient with an unscarred bicornuate uterus at term. 61
29593991 2017
37
A case report of bicornis bicollis uterus with unilateral cervical atresia: an unusual aetiology of chronic debilitating pelvic pain in a Cameroonian teenager. 61
28578675 2017
38
Novel de novo variant in EBF3 is likely to impact DNA binding in a patient with a neurodevelopmental disorder and expanded phenotypes: patient report, in silico functional assessment, and review of published cases. 61
28487885 2017
39
Endometrial cancer with congenital uterine anomalies: 3 case reports and a literature review. 61
28118070 2017
40
Familial deletion of the HOXA gene cluster associated with Hand-Foot-Genital syndrome and phenotypic variability. 61
27649277 2017
41
Moebius sequence -a multidisciplinary clinical approach. 61
28061881 2017
42
Bakri balloon placement in the successful management of postpartum hemorrhage in a bicornuate uterus: A case report. 61
28189983 2017
43
Placenta Percreta in a Gravid Bicornuate Unicollis Uterus. 61
28695030 2017
44
21-Year-Old Pregnant Woman with MODY-5 Diabetes. 61
29163993 2017
45
[Uterine Rupture at 18 Weeks of Pregnancy in the Context of Malformed Uterus]. 61
28103463 2016
46
Term Live Secondary Abdominal Pregnancy: A Case Report. 61
27904431 2016
47
An unusual cause of urinary incontinence: Urethral coitus in a case of Mayer-Rokitansky-Kuster-Hauser syndrome. 61
27617320 2016
48
Successful term delivery of spontaneous twin pregnancy in a woman with bicorporeal septate uterus: A case report. 61
27094222 2016
49
Imaging in Infertile Female Patients Who Underwent Hysterosalpingography Investigation at Dhulikhel Hospital. 61
28814690 2016
50
Uterine incarceration in a primigravid retroverted bicornuate uterus. 61
27402652 2016

Variations for Bicornuate Uterus

ClinVar genetic disease variations for Bicornuate Uterus:

6 ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 46;X;t(X;10)(p11.2;q24.3)Translocation Uncertain significance 267803

Expression for Bicornuate Uterus

Search GEO for disease gene expression data for Bicornuate Uterus.

Pathways for Bicornuate Uterus

GO Terms for Bicornuate Uterus

Sources for Bicornuate Uterus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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