Bilateral Breast Cancer disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: BLT006 MIFTS: 47	Bilateral Breast Cancer Categories: Cancer diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Bilateral Breast Cancer

MalaCards integrated aliases for Bilateral Breast Cancer:

Name: Bilateral Breast Cancer ¹² ⁵⁶ ¹⁵ ⁷⁴

Bilateral Breast Carcinoma ¹² ⁶

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:6741

NCIt ⁵¹ C8287

UMLS ⁷⁴ C0281267

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Summaries for Bilateral Breast Cancer

Disease Ontology : ¹² A breast carcinoma that is characterized by an individual having breast cancer in both breasts, either simultaneously or at different times.

MalaCards based summary : Bilateral Breast Cancer, also known as bilateral breast carcinoma, is related to synchronous bilateral breast carcinoma and papillary serous adenocarcinoma. An important gene associated with Bilateral Breast Cancer is BRCA2 (BRCA2 DNA Repair Associated), and among its related pathways/superpathways are Cell Cycle, Mitotic and DNA Double-Strand Break Repair. The drugs Trastuzumab and Paclitaxel have been mentioned in the context of this disorder. Affiliated tissues include breast, prostate and thyroid, and related phenotypes are Decreased homologous recombination repair frequency and Decreased homologous recombination repair frequency

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Related Diseases for Bilateral Breast Cancer

Diseases related to Bilateral Breast Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 145)

#	Related Disease	Score	Top Affiliating Genes
1	synchronous bilateral breast carcinoma	33.4	ATM BRCA1 BRCA2 PGR
2	papillary serous adenocarcinoma	29.9	BRCA1 PGR
3	ataxia-telangiectasia	29.7	ATM BRCA1 CHEK2
4	mammary paget's disease	29.5	ERBB2 PGR
5	li-fraumeni syndrome	29.5	ATM BRCA1 BRCA2 CHEK2
6	in situ carcinoma	29.4	BRCA1 ERBB2 PGR
7	breast fibroadenoma	29.4	ERBB2 PGR
8	cervical adenocarcinoma	29.2	ERBB2 PGR
9	ductal carcinoma in situ	29.2	BRCA1 BRCA2 ERBB2 PGR
10	breast cancer	28.7	ATM BRCA1 BRCA2 CHEK2 ERBB2 FHIT
11	ovarian cancer	27.8	ATM BRCA1 BRCA2 CHEK2 ERBB2 PALB2
12	sporadic breast cancer	27.6	ATM BRCA1 BRCA2 CHEK2 ERBB2 FHIT
13	hereditary site-specific ovarian cancer syndrome	10.3	BRCA1 BRCA2
14	breast reconstruction	10.3	BRCA1 BRCA2
15	breast-ovarian cancer, familial 1	10.3	BRCA1 BRCA2
16	premature menopause	10.3	BRCA1 BRCA2
17	fallopian tube disease	10.3	BRCA1 BRCA2
18	lynch syndrome i	10.2	BRCA1 BRCA2
19	mutagen sensitivity	10.2	BRCA1 BRCA2
20	fanconi anemia, complementation group u	10.2	BRCA1 RAD51
21	fanconi anemia, complementation group d2	10.2	BRCA2 RAD51
22	clivus chordoma	10.2	ATM CHEK2
23	fanconi anemia, complementation group v	10.2	BRCA1 RAD51
24	uterine corpus serous adenocarcinoma	10.1	BRCA1 ERBB2
25	corneal abscess	10.1	PGR RAD51
26	fanconi anemia, complementation group r	10.1	BRCA1 RAD51
27	lobular neoplasia	10.1	BRCA1 ERBB2
28	fanconi anemia, complementation group t	10.1	BRCA1 RAD51
29	congenital hypoplastic anemia	10.1	BRCA2 RAD51
30	fanconi anemia, complementation group q	10.1	BRCA1 BRCA2 RAD51
31	nijmegen breakage syndrome	10.1	ATM BRCA1 CHEK2
32	t-cell prolymphocytic leukemia	10.1	ATM CHEK2
33	scirrhous adenocarcinoma	10.1	ERBB2 PGR
34	breast apocrine carcinoma	10.1	ERBB2 PGR
35	glassy cell carcinoma of the cervix	10.1	ERBB2 PGR
36	tracheoesophageal fistula with or without esophageal atresia	10.1	BRCA2 PALB2
37	nosophobia	10.1	BRCA1 BRCA2 PGR
38	cancerophobia	10.1	BRCA1 BRCA2 PGR
39	tracheoesophageal fistula	10.1	BRCA2 PALB2
40	isolated tracheoesophageal fistula	10.1	BRCA2 PALB2
41	intracystic papillary adenoma	10.1	ERBB2 PGR
42	glycogen-rich clear cell breast carcinoma	10.0	BRCA1 BRCA2 PGR
43	breast metaplastic carcinoma	10.0	ERBB2 PGR
44	progesterone-receptor negative breast cancer	10.0	ERBB2 PGR
45	breast scirrhous carcinoma	10.0	ERBB2 PGR
46	dysgerminoma of ovary	10.0	BRCA1 BRCA2 PGR
47	progesterone-receptor positive breast cancer	10.0	ERBB2 PGR
48	apocrine adenocarcinoma	10.0	ERBB2 PGR
49	fanconi anemia, complementation group n	10.0	BRCA2 PALB2
50	uterine body mixed cancer	10.0	ERBB2 PGR

Graphical network of the top 20 diseases related to Bilateral Breast Cancer:

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Symptoms & Phenotypes for Bilateral Breast Cancer

GenomeRNAi Phenotypes related to Bilateral Breast Cancer according to GeneCards Suite gene sharing:

²⁷ (show all 17)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased homologous recombination repair frequency	GR00151-A-1	10.83	BRCA1 RAD51
2	Decreased homologous recombination repair frequency	GR00151-A-2	10.83	BRCA1 RAD51
3	Decreased homologous recombination repair frequency	GR00236-A-1	10.83	BRCA1 BRCA2 PALB2 PGR RAD51
4	Decreased homologous recombination repair frequency	GR00236-A-2	10.83	BRCA1 BRCA2 PALB2 PGR RAD51 ATM
5	Decreased homologous recombination repair frequency	GR00236-A-3	10.83	BRCA1 BRCA2 PALB2 RAD51
6	Decreased viability	GR00221-A-2	10.24	BRCA1 CHEK2
7	Decreased viability	GR00221-A-3	10.24	ATM BRCA1 CHEK2 ERBB2
8	Decreased viability	GR00221-A-4	10.24	ATM CHEK2 ERBB2
9	Decreased viability	GR00301-A	10.24	BRCA1
10	Decreased viability	GR00342-S-2	10.24	CHEK2
11	Decreased viability	GR00402-S-2	10.24	ATM BRCA1 CHEK2 ERBB2
12	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-1	9.64	ATM BRCA1 BRCA2 CHEK2 PALB2
13	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-2	9.64	ATM BRCA1 BRCA2 CHEK2 PALB2 RAD51
14	Increased viability with MLN4924 (a NAE inhibitor)	GR00250-A-3	9.63	ATM BRCA1 BRCA2 CHEK2 PALB2 RAD51
15	Decreased viability after ionizing radiation	GR00232-A-2	9.5	ATM BRCA1 BRCA2
16	Decreased viability with cisplatin	GR00101-A-4	9.43	BRCA1 BRCA2 RAD51
17	Synthetic lethal with cisplatin	GR00101-A-1	9.13	BRCA1 BRCA2 RAD51

MGI Mouse Phenotypes related to Bilateral Breast Cancer:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	10.01	ATM BRCA1 BRCA2 CHEK2 ERBB2 PALB2
2	embryo	MP:0005380	9.91	ATM BRCA1 BRCA2 ERBB2 PALB2 PGR
3	endocrine/exocrine gland	MP:0005379	9.8	ATM BRCA1 BRCA2 CHEK2 ERBB2 PGR
4	integument	MP:0010771	9.8	ATM BRCA1 BRCA2 ERBB2 FHIT PALB2
5	mortality/aging	MP:0010768	9.61	ATM BRCA1 BRCA2 CHEK2 ERBB2 FHIT
6	limbs/digits/tail	MP:0005371	9.55	BRCA1 BRCA2 ERBB2 PALB2 PGR
7	neoplasm	MP:0002006	9.23	ATM BRCA1 BRCA2 CHEK2 ERBB2 FHIT

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Drugs & Therapeutics for Bilateral Breast Cancer

Drugs for Bilateral Breast Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 63)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Trastuzumab

Approved, Investigational

Phase 3

180288-69-1

9903

Paclitaxel

Approved, Vet_approved

Phase 3

33069-62-4

36314

Atezolizumab

Approved, Investigational

Phase 3

1380723-44-3

Carboplatin

Approved

Phase 3

41575-94-4

10339178 38904 498142

Cyclophosphamide

Approved, Investigational

Phase 3,Phase 2

50-18-0, 6055-19-2

2907

Pertuzumab

Approved

Phase 3

380610-27-5, 145040-37-5

2540

Doxorubicin

Approved, Investigational

Phase 3

23214-92-8

31703

Exemestane

Approved, Investigational

Phase 3

107868-30-4

60198

Tamoxifen

Approved

Phase 3

10540-29-1

2733526

Anastrozole

Approved, Investigational

Phase 3

120511-73-1

2187

Sodium Citrate

Approved, Investigational

Phase 3

68-04-2

Letrozole

Approved, Investigational

Phase 3

112809-51-5

3902

Calcium

Approved, Nutraceutical

Phase 3

7440-70-2

271

Citric Acid

Approved, Nutraceutical, Vet_approved

Phase 3

77-92-9

311

Doxil

Approved June 1999

Phase 3

31703

Immunoglobulins

Phase 3

Anti-Bacterial Agents

Phase 3

Antineoplastic Agents, Alkylating

Phase 3,Phase 2

Antibodies, Monoclonal

Phase 3

Antineoplastic Agents, Immunological

Phase 3

Immunosuppressive Agents

Phase 3,Phase 2

Antibodies

Phase 3

Immunologic Factors

Phase 3,Phase 2

Topoisomerase Inhibitors

Phase 3

Alkylating Agents

Phase 3,Phase 2

Antibiotics, Antitubercular

Phase 3

Antimitotic Agents

Phase 3,Phase 2

Albumin-Bound Paclitaxel

Phase 3

Antineoplastic Agents, Phytogenic

Phase 3

Antirheumatic Agents

Phase 3,Phase 2

Estrogen Receptor Modulators

Phase 3

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 3

Estrogens

Phase 3

Calcium, Dietary

Phase 3

Anticoagulants

Phase 3

Citrate

Phase 3

Selective Estrogen Receptor Modulators

Phase 3

Antineoplastic Agents, Hormonal

Phase 3

Hormone Antagonists

Phase 3

Steroid Synthesis Inhibitors

Phase 3

Chelating Agents

Phase 3

Estrogen Antagonists

Phase 3

Hormones

Phase 3

Aromatase Inhibitors

Phase 3

Estrogen Receptor Antagonists

Phase 3

Bone Density Conservation Agents

Phase 3

Sargramostim

Approved, Investigational

Phase 2

123774-72-1, 83869-56-1

leucovorin

Approved

Phase 2

58-05-9

143 6006

Folic Acid

Approved, Nutraceutical, Vet_approved

Phase 2

59-30-3

6037

Emodepside

Investigational, Vet_approved

Phase 2

155030-63-0

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Neoadjuvant Treatment of HER2 Positive Early High-risk and Locally Advanced Breast Cancer	Recruiting	NCT03595592	Phase 3	Trastuzumab;Pertuzumab;Carboplatin;Paclitaxel;Doxorubicin;Cyclophosphamide;Atezolizumab
2	Tamoxifen Citrate, Letrozole, Anastrozole, or Exemestane With or Without Chemotherapy in Treating Patients With Invasive RxPONDER Breast Cancer	Active, not recruiting	NCT01272037	Phase 3	Anastrozole;Exemestane;Letrozole;Systemic Chemotherapy;Tamoxifen Citrate
3	Multi-epitope Folate Receptor Alpha Peptide Vaccine, Sargramostim, and Cyclophosphamide in Treating Patients With Triple Negative Breast Cancer	Recruiting	NCT03012100	Phase 2	Cyclophosphamide
4	Ixabepilone in Treating Participants With Significant Residual Disease of HER2/Neu Negative Invasive Breast Cancer After Systemic Therapy	Active, not recruiting	NCT00877500	Phase 2	Ixabepilone
5	Pre-operative Magnetic Resonance Imaging (MRI) in Young Breast Cancer Patients	Unknown status	NCT00801476	Not Applicable
6	EMG at Performing ULTN 1 in Breast Cancer Patients	Completed	NCT02599467	Not Applicable
7	Study of Radiation Exposure and Bilateral Breast Cancer	Active, not recruiting	NCT00903591
8	Genetic Counseling for Breast Cancer Survivors (GC for BC)	Active, not recruiting	NCT02451735	Not Applicable

Search NIH Clinical Center for Bilateral Breast Cancer

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Genetic Tests for Bilateral Breast Cancer

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Anatomical Context for Bilateral Breast Cancer

MalaCards organs/tissues related to Bilateral Breast Cancer:

⁴²

Breast, Prostate, Thyroid, Bone, Ovary, Lung, Lymph Node

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Publications for Bilateral Breast Cancer

Articles related to Bilateral Breast Cancer:

(show top 50) (show all 270)

#	Title	Authors	Year
1	Body mass index and diabetes are important prognostic signatures for bilateral breast cancer prognosis. ( 30618092 )	Zhang M...Zhang J	2019
2	Bilateral erector spinae nerve block using one injection for bilateral breast cancer surgery. ( 30776776 )	Ueshima H	2019
3	Breast cancer mortality in synchronous bilateral breast cancer patients. ( 30804429 )	Mejdahl MK...Kroman N	2019
4	Skin and lung toxicity in synchronous bilateral breast cancer treated with volumetric-modulated arc radiotherapy: a mono-institutional experience. ( 30875061 )	Valli M...Richetti A	2019
5	Evaluation of optimal treatment planning for radiotherapy of synchronous bilateral breast cancer including regional lymph node irradiation. ( 30935400 )	Cho Y...Lee IJ	2019
6	Whole Exome Sequencing in the Accurate Diagnosis of Bilateral Breast Cancer: a Case Study. ( 30941240 )	Li X...Wang K	2019
7	The prognostic comparison among unilateral, bilateral, synchronous bilateral, and metachronous bilateral breast cancer: A meta-analysis of studies from recent decade (2008-2018). ( 31038845 )	Pan B...Sun Q	2019
8	Bilateral Breast Cancer After Multimodality Treatment: A Report of Clinical Outcomes in an Asian Population. ( 29254601 )	Wadasadawala T...Sarin R	2018
9	Dissecting Time- from Tumor-Related Gene Expression Variability in Bilateral Breast Cancer. ( 29315233 )	Callari M...Cappelletti V	2018
10	Delayed Recurrent and Bilateral Breast Cancer in Patients With Partial Poland's Anomaly: Report of 2 Rare Cases and Review of the Literature. ( 29475749 )	DeFazio MV...Willey SC	2018
11	Sequential Sentinel Node Scintigraphy With Planar and SPECT/CT Images Revealed Contralateral Drainage From Ipsilateral Breast Tumor Relapse in a Patient With Bilateral Breast Cancer. ( 29659396 )	Koizumi M...Miyagi Y	2018
12	Including internal mammary lymph nodes in radiation therapy for synchronous bilateral breast cancer: an international survey of treatment technique and clinical priorities. ( 29869775 )	Roumeliotis M...Quirk S	2018
13	Synchronous bilateral breast cancer patients submitted to conservative treatment and brachytherapy - The experience of a service. ( 30127671 )	Pinheiro J...Trigo L	2018
14	Synchronous bilateral breast cancer: A case report of heterogeneous estrogen receptor status. ( 30391732 )	Dhadlie S...Hendahewa R	2018
15	Favorable progression-free survival in women with two different histopathological subtypes of bilateral breast cancer. ( 30589050 )	Wang Y...Yan X	2018
16	Synchronous and metachronous bilateral breast cancer: A long-term experience. ( 30610782 )	Ozturk A...Ozmen V	2018
17	Radiation therapy of synchronous bilateral breast carcinoma (SBBC) using multiple techniques. ( 28988893 )	Kim SJ...Youn SM	2018
18	pCR rates in patients with bilateral breast cancer after neoadjuvant anthracycline-taxane based-chemotherapy - A retrospective pooled analysis of individual patients data of four German neoadjuvant trials. ( 28063331 )	Reinisch M...Loibl S	2017
19	Synchronous Bilateral Breast Cancer in a Patient With Nager Syndrome. ( 28139434 )	Denu RA...Burkard ME	2017
20	Synchronous bilateral breast cancer irradiation: clinical and dosimetrical issues using volumetric modulated arc therapy and simultaneous integrated boost. ( 28224401 )	Fiorentino A...Alongi F	2017
21	Bilateral Breast Cancer After Prophylactic Bilateral Pulmonary Irradiation. ( 28272005 )	El Meddeb HA...Bouaouina N	2017
22	Gastric metastasis of bilateral breast cancer. ( 28280631 )	Jmour O...Benna F	2017
23	Synchronous Bilateral Breast Cancer With Discordant Histology. ( 28412779 )	Copur MS...Clark D	2017
24	PALB2 mutation in a woman with bilateral breast cancer: A case report. ( 28413668 )	Nakagomi H...Omata M	2017
25	First clinical report of helical tomotherapy with simultaneous integrated boost for synchronous bilateral breast cancer. ( 28707988 )	Wadasadawala T...Sarin R	2017
26	Treatment of bilateral breast cancer and regional nodes using an opposed lateral beam arrangement. ( 28867548 )	Farooqi AS...Shaitelman SF	2017
27	Bilateral Breast Cancer with Neurofibromatosis Type 1 Patient: Case Report. ( 29082380 )	Dursun D...Olgun N	2017
28	Long-term effects of first degree family history of breast cancer in young women: Recurrences and bilateral breast cancer. ( 26399280 )	Jobsen JJ...Struikmans H	2016
29	Femoral Placement of Totally Implantable Venous Access Ports in Patients with Bilateral Breast Cancer. ( 26855441 )	Almasi-Sperling V...Sagban TA	2016
30	Unilateral Arm Urticaria Presenting as a Paraneoplastic Manifestation of Metachronous Bilateral Breast Cancer. ( 26933416 )	Kasi PM...Haddad TC	2016
31	Helical tomotherapy for bilateral breast cancer: Clinical experience. ( 27253152 )	Kaidar-Person O...Marks LB	2016
32	Image-guided intensity-modulated radiotherapy for refractory bilateral breast cancer in a patient with extensive cutaneous metastasis in the chest and abdominal walls. ( 27284253 )	Lu YF...Hsieh CH	2016
33	Co-existence of a giant cell tumour of the tendon sheath and schwannoma in a patient with bilateral breast cancer: A potential cause of false positive findings in 18F-FDG PET/CT studies. ( 27329560 )	Ortega Candil A...Carreras Delgado JL	2016
34	BILATERAL BREAST CANCER: DIAGNOSIS AND PROGNOSIS. ( 27483711 )	Ursaru M...Negru D	2016
35	Challenges of treating incidental synchronous bilateral breast cancer with differing tumour biology. ( 27539136 )	Esclovon JW...Misra S	2016
36	Bilateral breast cancer resection performed under the bilateral transversus thoracic muscle plane block. ( 27555202 )	Ueshima H...Otake H	2016
37	Disease evolution and heterogeneity in bilateral breast cancer. ( 27904775 )	Fountzilas E...Fountzilas G	2016
38	EVOLUTION OF SYNCHRONOUS BILATERAL BREAST CARCINOMA IN A YOUNG PATIENT. ( 27125095 )	Manea E...Munteanu A	2016
39	Prostate cancer in a man with a BRCA2 mutation and a personal history of bilateral breast cancer. ( 25112434 )	Singer CF...Narod SA	2015
40	Use of tomotherapy in treatment of synchronous bilateral breast cancer: dosimetric comparison study. ( 25605345 )	Wadasadawala T...Phurailatpam R	2015
41	Impact of bilateral breast cancer on prognosis: synchronous versus metachronous tumors. ( 25735321 )	Ibrahim NY...Darwish DO	2015
42	Metabolic flare phenomenon on 18 fluoride-fluorodeoxy glucose positron emission tomography-computed tomography scans in a patient with bilateral breast cancer treated with second-line chemotherapy and bevacizumab. ( 25829734 )	Balasubramanian Harisankar CN...John J	2015
43	Surgical management for early-stage bilateral breast cancer patients in China. ( 25874699 )	Chen JJ...Wu J	2015
44	Bilateral breast cancer following augmentation mammaplasty with polyacrylamide hydrogel injection: A case report. ( 26137129 )	Zhao Y...Zhao X	2015
45	Breast-Conserving Surgery in Bilateral Breast Cancer. ( 26265365 )	O'Brien JA...Gemignani ML	2015
46	Bilateral breast cancer, synchronous and metachronous; differences and outcome. ( 26268697 )	Jobsen JJ...Struikmans H	2015
47	Coexistence of systemic lupus erythematosus, Hashimoto's thyroiditis, and bilateral breast cancer in the same patient: a random association? ( 26399842 )	Molinelli E...Offidani A	2015
48	Multifocal Bilateral Breast Cancer and Breast Follicular Lymphoma: A Simple Coincidence? ( 26472982 )	Michalinos A...Kontos M	2015
49	Bilateral breast cancer with a unilateral carcinoma within a fibroadenoma: A case report. ( 26622700 )	Zheng H...Qi C	2015
50	A case of synchronous multiple bilateral breast cancer after breast augmentation. ( 26722625 )	Yamamoto S...Matsubara Y	2015

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Genes for Bilateral Breast Cancer

Genes related to Bilateral Breast Cancer (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	BRCA2	BRCA2 DNA Repair Associated	Protein Coding	35.94	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	11556836 10573018 19649703 (more) 19372713 15319244 19127556 11793480 10699917 11389159 19153073 11802208 11149425 20104584 10188893 16331614 19288190 11130383 19698031
2	BRCA1	BRCA1 DNA Repair Associated	Protein Coding	35.9	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	11556836 10573018 17557253 (more) 19372713 8723683 15319244 10737987 9145677 19629752 8281142 19736894 19153073 11802208 11389159 11149425 20104584 10188893 19649703 16331614 12151349 9333265 7627958 11130383 19127556 19393826
3	ATM	ATM Serine/Threonine Kinase	Protein Coding	30.29	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	19153073 12673797 14562025 (more) 15756685 18264724
4	CHEK2	Checkpoint Kinase 2	Protein Coding	30.19	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	19372713
5	RAD51	RAD51 Recombinase	Protein Coding	25	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	17666788 10807537
6	FHIT	Fragile Histidine Triad Diadenosine Triphosphatase	Protein Coding	24.99	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	9157994
7	PGR	Progesterone Receptor	Protein Coding	22.74	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶	7651928
8	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	22.73	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	PALB2	Partner And Localizer Of BRCA2	Protein Coding	21.28	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

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Variations for Bilateral Breast Cancer

ClinVar genetic disease variations for Bilateral Breast Cancer:

⁶

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	ATM	NM_000051.3(ATM): c.2021A> G (p.His674Arg)	single nucleotide variant	Conflicting interpretations of pathogenicity	rs201762714	GRCh37	Chromosome 11, 108124663: 108124663
2	ATM	NM_000051.3(ATM): c.2021A> G (p.His674Arg)	single nucleotide variant	Conflicting interpretations of pathogenicity	rs201762714	GRCh38	Chromosome 11, 108253936: 108253936

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Expression for Bilateral Breast Cancer

Search GEO for disease gene expression data for Bilateral Breast Cancer.

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Pathways for Bilateral Breast Cancer

Pathways related to Bilateral Breast Cancer according to GeneCards Suite gene sharing:

(show all 33)

#	Super pathways	Score	Top Affiliating Genes
1	Cell Cycle, Mitotic ⁶⁷ Show member pathways Cell Cycle ⁶⁷ M Phase ⁶⁷	13.2	ATM BRCA1 BRCA2 CHEK2 RAD51
2	DNA Double-Strand Break Repair ⁶⁷ Show member pathways Chk1/Chk2(Cds1) mediated inactivation of Cyclin B-Cdk1 complex ⁶⁷ DNA damage_DNA-damage-induced responses ²³ DNA Repair ⁶⁷ G2/M DNA damage checkpoint ⁶⁷ HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) ⁶⁷ HDR through MMEJ (alt-NHEJ) ⁶⁷ Homology Directed Repair ⁶⁷ Non-homologous end joining ¹ Non-homologous end-joining ³⁸ Processing of DNA double-strand break ends ⁶⁷	13	ATM BRCA1 BRCA2 CHEK2 PALB2 RAD51
3	TCR Signaling (Qiagen) ⁶⁵ Show member pathways Fc-EpsilonRI Pathway ⁶⁵ ITK and TCR Signaling ⁶⁵ PKC-Theta Pathway ⁶⁵ TCR Signaling ⁶⁵	12.74	ATM BRCA1 BRCA2 CHEK2 RAD51
4	Gastric cancer ³⁸ Show member pathways Breast cancer ³⁸ Hepatocellular carcinoma ³⁸	12.56	BRCA1 BRCA2 ERBB2 PGR
5	Glioma ³⁸ Show member pathways Endocrine resistance ³⁸ Melanoma ³⁸ Non-small cell lung cancer ³⁸ Signaling Pathways in Glioblastoma ¹	12.5	ATM BRCA1 BRCA2 ERBB2 FHIT
6	Chks in Checkpoint Regulation ⁶⁵ Show member pathways DNA Repair Mechanisms ⁶⁵ Estrogen-mediated S-Phase Entry ⁶⁵ G2-M Phase Transition ⁶⁵ Parkinson's Disease Pathway ⁶⁵ SREBP Proteolysis ⁶⁵	12.5	ATM BRCA1 BRCA2 CHEK2 RAD51
7	Meiosis ⁶⁷ Show member pathways Meiotic recombination ⁶⁷ Meiotic synapsis ⁶⁷	12.35	ATM BRCA1 BRCA2 RAD51
8	DNA Damage ⁴	12.33	ATM BRCA1 BRCA2 CHEK2 RAD51
9	MicroRNAs in cancer ³⁸	12.31	ATM BRCA1 ERBB2
10	Apoptosis Pathway ⁷³ Show member pathways Akt Pathway ⁷³ NF-kappaB Pathway ⁷³	12.24	ATM CHEK2 ERBB2
11	DNA Damage Response ¹ Show member pathways miRNA Regulation of DNA Damage Response ¹ p53 signaling pathway ³⁸	12.23	ATM BRCA1 CHEK2 RAD51
12	DNA Double Strand Break Response ⁶⁷ Show member pathways Nonhomologous End-Joining (NHEJ) ⁶⁷ Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks ⁶⁷ Sensing of DNA Double Strand Breaks ⁶⁷	12.17	ATM BRCA1 CHEK2
13	p53 Signaling ⁶⁵ Show member pathways p53 Pathway ⁶⁸	12.06	ATM BRCA1 CHEK2
14	Cell cycle Role of SCF complex in cell cycle regulation ²³ Show member pathways Cell cycle ESR1 regulation of G1/S transition ²³ Cell cycle Regulation of G1/S transition (part 1) ²³ Immune response MIF-JAB1 signaling ²³	12.03	BRCA1 CHEK2 PGR
15	Homologous DNA Pairing and Strand Exchange ⁶⁷ Show member pathways ATR Signaling ¹ HDR through Homologous Recombination (HRR) ⁶⁷ HDR through Single Strand Annealing (SSA) ⁶⁷ Presynaptic phase of homologous DNA pairing and strand exchange ⁶⁷	12.02	ATM BRCA1 BRCA2 PALB2 RAD51
16	Integrated Breast Cancer Pathway ¹	11.74	ATM BRCA1 BRCA2 CHEK2 RAD51
17	Fanconi anemia pathway ³⁸ ⁶⁷	11.71	BRCA1 BRCA2 PALB2 RAD51
18	ATM Pathway ⁶⁵ Show member pathways ATM Signaling Pathway ¹	11.64	ATM BRCA1 CHEK2 RAD51
19	Platinum drug resistance ³⁸	11.62	ATM BRCA1 ERBB2
20	Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) ⁶⁷ Show member pathways Homologous recombination ¹ Homologous recombination ³⁸ Resolution of D-Loop Structures ⁶⁷ Resolution of D-loop Structures through Holliday Junction Intermediates ⁶⁷	11.54	ATM BRCA1 BRCA2 PALB2 RAD51
21	Pathways Affected in Adenoid Cystic Carcinoma ¹	11.49	ATM BRCA1 CHEK2 ERBB2
22	Integrated Cancer Pathway ¹	11.39	ATM BRCA1 CHEK2
23	DNA damage_ATM/ATR regulation of G1/S checkpoint ²³	11.36	ATM BRCA1 CHEK2
24	ATM Signaling Network in Development and Disease ¹	11.32	ATM CHEK2
25	Cell cycle Role of 14-3-3 proteins in cell cycle regulation ²³ Show member pathways 14-3-3 and Cell Cycle Regulation ⁶⁵	11.3	ATM CHEK2
26	DNA damage_Role of Brca1 and Brca2 in DNA repair ²³	11.26	ATM BRCA1 BRCA2 CHEK2 RAD51
27	FOXM1 transcription factor network ¹	11.21	BRCA2 CHEK2
28	GADD45 Pathway ⁶⁵	11.13	ATM BRCA1
29	Ovarian Infertility Genes ¹	11.13	ATM PGR
30	BARD1 signaling events ¹	11.12	ATM BRCA1 RAD51
31	Gemtuzumab ozogamicin Pathway, Pharmacokinetics/Pharmacodynamics ⁶²	10.98	ATM CHEK2
32	BRCA1 Pathway ⁶⁵ Show member pathways Fanconi's Anaemia Pathway ⁶⁵	10.94	ATM BRCA1 BRCA2 CHEK2 RAD51
33	DNA Damage Induced 14-3-3Sigma Signaling ⁶⁵	10.88	ATM BRCA1

Sources

GO Terms for Bilateral Breast Cancer

Cellular components related to Bilateral Breast Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nucleoplasm	GO:0005654	9.8	ATM BRCA1 BRCA2 CHEK2 PALB2 PGR
2	nucleus	GO:0005634	9.61	ATM BRCA1 BRCA2 CHEK2 ERBB2 FHIT
3	condensed nuclear chromosome	GO:0000794	9.37	BRCA1 RAD51
4	nuclear chromosome, telomeric region	GO:0000784	9.33	ATM BRCA2 RAD51
5	condensed chromosome	GO:0000793	9.32	BRCA1 RAD51
6	lateral element	GO:0000800	8.8	BRCA1 BRCA2 RAD51
7	cytoplasm	GO:0005737	10.01	ATM BRCA1 BRCA2 CHEK2 ERBB2 FHIT

Biological processes related to Bilateral Breast Cancer according to GeneCards Suite gene sharing:

(show all 26)

#	Name	GO ID	Score	Top Affiliating Genes
1	apoptotic process	GO:0006915	9.91	ATM BRCA1 CHEK2 FHIT
2	cell cycle	GO:0007049	9.87	ATM BRCA1 BRCA2 CHEK2
3	protein autophosphorylation	GO:0046777	9.72	ATM CHEK2 ERBB2
4	DNA recombination	GO:0006310	9.67	BRCA1 BRCA2 PALB2 RAD51
5	positive regulation of cell adhesion	GO:0045785	9.63	ATM ERBB2
6	double-strand break repair	GO:0006302	9.63	BRCA1 BRCA2 CHEK2
7	cellular response to DNA damage stimulus	GO:0006974	9.63	ATM BRCA1 BRCA2 CHEK2 PALB2 RAD51
8	response to ionizing radiation	GO:0010212	9.62	ATM BRCA1
9	negative regulation of G0 to G1 transition	GO:0070317	9.62	BRCA1 RAD51
10	double-strand break repair via homologous recombination	GO:0000724	9.62	BRCA1 BRCA2 PALB2 RAD51
11	DNA damage checkpoint	GO:0000077	9.6	ATM CHEK2
12	reciprocal meiotic recombination	GO:0007131	9.59	ATM RAD51
13	response to gamma radiation	GO:0010332	9.58	BRCA2 CHEK2
14	cellular response to gamma radiation	GO:0071480	9.58	ATM CHEK2
15	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	GO:0042771	9.56	BRCA2 CHEK2
16	DNA double-strand break processing	GO:0000729	9.54	ATM BRCA1
17	replicative senescence	GO:0090399	9.52	ATM CHEK2
18	inner cell mass cell proliferation	GO:0001833	9.51	BRCA2 PALB2
19	telomere maintenance via recombination	GO:0000722	9.49	BRCA2 RAD51
20	DNA damage induced protein phosphorylation	GO:0006975	9.48	ATM CHEK2
21	chordate embryonic development	GO:0043009	9.43	BRCA1 BRCA2
22	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO:0006978	9.43	BRCA1 BRCA2 CHEK2
23	mitotic recombination-dependent replication fork processing	GO:1990426	9.4	BRCA2 RAD51
24	mammary gland development	GO:0030879	9.31	PGR
25	intrinsic apoptotic signaling pathway in response to DNA damage	GO:0008630	9.26	ATM BRCA1 BRCA2 CHEK2
26	DNA repair	GO:0006281	9.1	ATM BRCA1 BRCA2 CHEK2 PALB2 RAD51

Molecular functions related to Bilateral Breast Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	DNA binding	GO:0003677	9.63	ATM BRCA1 BRCA2 PALB2 PGR RAD51
2	ubiquitin protein ligase binding	GO:0031625	9.5	BRCA1 CHEK2 FHIT
3	protein C-terminus binding	GO:0008022	9.43	BRCA2 ERBB2 RAD51
4	nucleotide binding	GO:0000166	9.35	ATM CHEK2 ERBB2 FHIT RAD51
5	identical protein binding	GO:0042802	9.17	BRCA1 BRCA2 CHEK2 ERBB2 FHIT PGR
6	protein binding	GO:0005515	10.02	ATM BRCA1 BRCA2 CHEK2 ERBB2 FHIT

Sources

Sources for Bilateral Breast Cancer

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia