Bilateral Breast Cancer disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: BLT006 MIFTS: 48	Bilateral Breast Cancer Categories: Cancer diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Bilateral Breast Cancer

MalaCards integrated aliases for Bilateral Breast Cancer:

Name: Bilateral Breast Cancer ¹² ⁵⁵ ¹⁵ ⁷³

Bilateral Breast Carcinoma ¹² ²⁹ ⁶

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:6741

NCIt ⁵⁰ C8287

UMLS ⁷³ C0281267

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Summaries for Bilateral Breast Cancer

Disease Ontology : ¹² A breast carcinoma that is characterized by an individual having breast cancer in both breasts, either simultaneously or at different times.

MalaCards based summary : Bilateral Breast Cancer, also known as bilateral breast carcinoma, is related to synchronous bilateral breast carcinoma and papillary serous adenocarcinoma. An important gene associated with Bilateral Breast Cancer is BRCA1 (BRCA1, DNA Repair Associated), and among its related pathways/superpathways are Cell Cycle, Mitotic and DNA Double-Strand Break Repair. The drugs Cyclophosphamide and Exemestane have been mentioned in the context of this disorder. Affiliated tissues include breast, bone and prostate, and related phenotypes are Decreased homologous recombination repair frequency and Decreased homologous recombination repair frequency

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Related Diseases for Bilateral Breast Cancer

Diseases related to Bilateral Breast Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 137)

#	Related Disease	Score	Top Affiliating Genes
1	synchronous bilateral breast carcinoma	33.5	ATM BRCA1 BRCA2 PGR
2	papillary serous adenocarcinoma	29.8	BRCA1 PGR
3	ataxia-telangiectasia	29.6	ATM BRCA1 CHEK2
4	breast cancer	29.6	ATM BRCA1 BRCA2 CHEK2 ERBB2 FHIT
5	li-fraumeni syndrome	29.5	ATM BRCA1 BRCA2 CHEK2
6	in situ carcinoma	29.5	BRCA1 ERBB2 PGR
7	ductal carcinoma in situ	29.3	BRCA1 BRCA2 ERBB2 PGR
8	ovarian cancer	28.4	ATM BRCA1 BRCA2 CHEK2 ERBB2 PALB2
9	sporadic breast cancer	28.3	ATM BRCA1 BRCA2 CHEK2 ERBB2 FHIT
10	hereditary site-specific ovarian cancer syndrome	10.2	BRCA1 BRCA2
11	breast reconstruction	10.2	BRCA1 BRCA2
12	breast-ovarian cancer, familial 1	10.2	BRCA1 BRCA2
13	premature menopause	10.2	BRCA1 BRCA2
14	fallopian tube disease	10.2	BRCA1 BRCA2
15	lynch syndrome i	10.1	BRCA1 BRCA2
16	mutagen sensitivity	10.1	BRCA1 BRCA2
17	fanconi anemia, complementation group u	10.1	BRCA1 RAD51
18	fanconi anemia, complementation group d2	10.1	BRCA2 RAD51
19	clivus chordoma	10.1	ATM CHEK2
20	fanconi anemia, complementation group v	10.1	BRCA1 RAD51
21	uterine corpus serous adenocarcinoma	10.1	BRCA1 ERBB2
22	fanconi anemia, complementation group r	10.1	BRCA1 RAD51
23	corneal abscess	10.1	PGR RAD51
24	lobular neoplasia	10.1	BRCA1 ERBB2
25	fanconi anemia, complementation group t	10.1	BRCA1 RAD51
26	congenital hypoplastic anemia	10.1	BRCA2 RAD51
27	fanconi anemia, complementation group q	10.1	BRCA1 BRCA2 RAD51
28	nijmegen breakage syndrome	10.0	ATM BRCA1 CHEK2
29	t-cell prolymphocytic leukemia	10.0	ATM CHEK2
30	scirrhous adenocarcinoma	10.0	ERBB2 PGR
31	breast apocrine carcinoma	10.0	ERBB2 PGR
32	glassy cell carcinoma of the cervix	10.0	ERBB2 PGR
33	tracheoesophageal fistula with or without esophageal atresia	10.0	BRCA2 PALB2
34	tracheoesophageal fistula	10.0	BRCA2 PALB2
35	nosophobia	10.0	BRCA1 BRCA2 PGR
36	cancerophobia	10.0	BRCA1 BRCA2 PGR
37	isolated tracheoesophageal fistula	10.0	BRCA2 PALB2
38	intracystic papillary adenoma	10.0	ERBB2 PGR
39	glycogen-rich clear cell breast carcinoma	10.0	BRCA1 BRCA2 PGR
40	breast metaplastic carcinoma	10.0	ERBB2 PGR
41	progesterone-receptor negative breast cancer	10.0	ERBB2 PGR
42	breast scirrhous carcinoma	10.0	ERBB2 PGR
43	dysgerminoma of ovary	10.0	BRCA1 BRCA2 PGR
44	pancreatic neuroendocrine tumor	10.0	BRCA2 PALB2
45	progesterone-receptor positive breast cancer	10.0	ERBB2 PGR
46	breast adenoid cystic carcinoma	10.0	ERBB2 PGR
47	apocrine adenocarcinoma	10.0	ERBB2 PGR
48	fanconi anemia, complementation group n	10.0	BRCA2 PALB2
49	uterine body mixed cancer	10.0	ERBB2 PGR
50	ovarian disease	10.0	BRCA1 BRCA2 PGR

Graphical network of the top 20 diseases related to Bilateral Breast Cancer:

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Symptoms & Phenotypes for Bilateral Breast Cancer

GenomeRNAi Phenotypes related to Bilateral Breast Cancer according to GeneCards Suite gene sharing:

²⁶ (show all 17)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased homologous recombination repair frequency	GR00151-A-1	10.83	BRCA1 RAD51
2	Decreased homologous recombination repair frequency	GR00151-A-2	10.83	BRCA1 RAD51
3	Decreased homologous recombination repair frequency	GR00236-A-1	10.83	BRCA1 BRCA2 PALB2 PGR RAD51
4	Decreased homologous recombination repair frequency	GR00236-A-2	10.83	BRCA1 BRCA2 PALB2 PGR RAD51 ATM
5	Decreased homologous recombination repair frequency	GR00236-A-3	10.83	BRCA1 BRCA2 PALB2 RAD51
6	Decreased viability	GR00221-A-2	10.24	BRCA1 CHEK2
7	Decreased viability	GR00221-A-3	10.24	ATM BRCA1 CHEK2 ERBB2
8	Decreased viability	GR00221-A-4	10.24	ATM CHEK2 ERBB2
9	Decreased viability	GR00301-A	10.24	BRCA1
10	Decreased viability	GR00342-S-2	10.24	CHEK2
11	Decreased viability	GR00402-S-2	10.24	ATM BRCA1 CHEK2 ERBB2
12	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-1	9.64	ATM BRCA1 BRCA2 CHEK2 PALB2
13	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-2	9.64	ATM BRCA1 BRCA2 CHEK2 PALB2 RAD51
14	Increased viability with MLN4924 (a NAE inhibitor)	GR00250-A-3	9.63	ATM BRCA1 BRCA2 CHEK2 PALB2 RAD51
15	Decreased viability after ionizing radiation	GR00232-A-2	9.5	ATM BRCA1 BRCA2
16	Decreased viability with cisplatin	GR00101-A-4	9.43	BRCA1 BRCA2 RAD51
17	Synthetic lethal with cisplatin	GR00101-A-1	9.13	BRCA1 BRCA2 RAD51

MGI Mouse Phenotypes related to Bilateral Breast Cancer:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	10.01	ATM BRCA1 BRCA2 CHEK2 ERBB2 PALB2
2	embryo	MP:0005380	9.91	ATM BRCA1 BRCA2 ERBB2 PALB2 PGR
3	endocrine/exocrine gland	MP:0005379	9.8	ATM BRCA1 BRCA2 CHEK2 ERBB2 PGR
4	integument	MP:0010771	9.8	ATM BRCA1 BRCA2 ERBB2 FHIT PALB2
5	mortality/aging	MP:0010768	9.61	ATM BRCA1 BRCA2 CHEK2 ERBB2 FHIT
6	limbs/digits/tail	MP:0005371	9.55	BRCA1 BRCA2 ERBB2 PALB2 PGR
7	neoplasm	MP:0002006	9.23	ATM BRCA1 BRCA2 CHEK2 ERBB2 FHIT

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Drugs & Therapeutics for Bilateral Breast Cancer

Drugs for Bilateral Breast Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 57)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Cyclophosphamide

Approved, Investigational

Phase 3,Phase 2

6055-19-2, 50-18-0

2907

Exemestane

Approved, Investigational

Phase 3

107868-30-4

60198

Letrozole

Approved, Investigational

Phase 3

112809-51-5

3902

Tamoxifen

Approved

Phase 3

10540-29-1

2733526

Anastrozole

Approved, Investigational

Phase 3

120511-73-1

2187

Paclitaxel

Approved, Vet_approved

Phase 3

33069-62-4

36314

Pertuzumab

Approved

Phase 3

145040-37-5, 380610-27-5

2540

Atezolizumab

Approved, Investigational

Phase 3

1380723-44-3

Carboplatin

Approved

Phase 3

41575-94-4

10339178 38904 498142

Trastuzumab

Approved, Investigational

Phase 3

180288-69-1

9903

Doxorubicin

Approved, Investigational

Phase 3

23214-92-8

31703

Citric Acid

Approved, Nutraceutical, Vet_approved

Phase 3

77-92-9

311

Doxil

Approved June 1999

Phase 3

31703

Immunologic Factors

Phase 3,Phase 2

Immunosuppressive Agents

Phase 3,Phase 2

Antineoplastic Agents, Alkylating

Phase 3,Phase 2

Antirheumatic Agents

Phase 3,Phase 2

Alkylating Agents

Phase 3,Phase 2

Bone Density Conservation Agents

Phase 3

Estrogen Antagonists

Phase 3

Antineoplastic Agents, Hormonal

Phase 3

Citrate

Phase 3

Hormones

Phase 3

Calcium, Dietary

Phase 3

Estrogen Receptor Modulators

Phase 3

Estrogens

Phase 3

Selective Estrogen Receptor Modulators

Phase 3

Steroid Synthesis Inhibitors

Phase 3

Estrogen Receptor Antagonists

Phase 3

Anticoagulants

Phase 3

Hormone Antagonists

Phase 3

Chelating Agents

Phase 3

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 3

Aromatase Inhibitors

Phase 3

Antimitotic Agents

Phase 3,Phase 2

Antibodies, Monoclonal

Phase 3

Topoisomerase Inhibitors

Phase 3

Antineoplastic Agents, Phytogenic

Phase 3

Antibiotics, Antitubercular

Phase 3

Albumin-Bound Paclitaxel

Phase 3

Anti-Bacterial Agents

Phase 3

Antibodies

Phase 3

Immunoglobulins

Phase 3

leucovorin

Approved

Phase 2

58-05-9

6006 143

Folic Acid

Approved, Nutraceutical, Vet_approved

Phase 2

59-30-3

6037

Vitamin B Complex

Phase 2

Vaccines

Phase 2

Vitamin B9

Phase 2

Vitamins

Phase 2

Trace Elements

Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Tamoxifen Citrate, Letrozole, Anastrozole, or Exemestane With or Without Chemotherapy in Treating Patients With Invasive RxPONDER Breast Cancer	Active, not recruiting	NCT01272037	Phase 3	Anastrozole;Exemestane;Letrozole;Systemic Chemotherapy;Tamoxifen Citrate
2	Neoadjuvant Treatment of HER2 Positive Early High-risk and Locally Advanced Breast Cancer	Not yet recruiting	NCT03595592	Phase 3	Trastuzumab;Pertuzumab;Carboplatin;Paclitaxel;Doxorubicin;Cyclophosphamide;Atezolizumab
3	Multi-epitope Folate Receptor Alpha Peptide Vaccine, Sargramostim, and Cyclophosphamide in Treating Patients With Triple Negative Breast Cancer	Recruiting	NCT03012100	Phase 2	Cyclophosphamide
4	Ixabepilone in Treating Participants With Significant Residual Disease of HER2/Neu Negative Invasive Breast Cancer After Systemic Therapy	Active, not recruiting	NCT00877500	Phase 2	Ixabepilone
5	Pre-operative Magnetic Resonance Imaging (MRI) in Young Breast Cancer Patients	Unknown status	NCT00801476	Not Applicable
6	EMG at Performing ULTN 1 in Breast Cancer Patients	Completed	NCT02599467	Not Applicable
7	Study of Radiation Exposure and Bilateral Breast Cancer	Active, not recruiting	NCT00903591
8	Genetic Counseling for Breast Cancer Survivors (GC for BC)	Active, not recruiting	NCT02451735	Not Applicable

Search NIH Clinical Center for Bilateral Breast Cancer

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Genetic Tests for Bilateral Breast Cancer

Genetic tests related to Bilateral Breast Cancer:

#	Genetic test	Affiliating Genes
1	Bilateral Breast Carcinoma ²⁹

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Anatomical Context for Bilateral Breast Cancer

MalaCards organs/tissues related to Bilateral Breast Cancer:

⁴¹

Breast, Bone, Prostate, Thyroid, Ovary, Cervix, Bone Marrow

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Publications for Bilateral Breast Cancer

Articles related to Bilateral Breast Cancer:

(show top 50) (show all 246)

#	Title	Authors	Year
1	Sequential Sentinel Node Scintigraphy With Planar and SPECT/CT Images Revealed Contralateral Drainage From Ipsilateral Breast Tumor Relapse in a Patient With Bilateral Breast Cancer. ( 29659396 )	Koizumi M....Miyagi Y.	2018
2	Including internal mammary lymph nodes in radiation therapy for synchronous bilateral breast cancer: an international survey of treatment technique and clinical priorities. ( 29869775 )	Roumeliotis M....Quirk S.	2018
3	Delayed Recurrent and Bilateral Breast Cancer in Patients With Partial Poland's Anomaly: Report of 2 Rare Cases and Review of the Literature. ( 29475749 )		2018
4	Dissecting Time- from Tumor-Related Gene Expression Variability in Bilateral Breast Cancer. ( 29315233 )		2018
5	Synchronous bilateral breast cancer patients submitted to conservative treatment and brachytherapy - The experience of a service. ( 30127671 )	Pinheiro J...Trigo L	2018
6	Synchronous bilateral breast cancer: A case report of heterogeneous estrogen receptor status. ( 30391732 )	Dhadlie S...Hendahewa R	2018
7	First clinical report of helical tomotherapy with simultaneous integrated boost for synchronous bilateral breast cancer. ( 28707988 )	Wadasadawala T....Sarin R.	2017
8	Synchronous Bilateral Breast Cancer in a Patient With Nager Syndrome. ( 28139434 )	Denu R.A....Burkard M.E.	2017
9	Bilateral Breast Cancer After Multimodality Treatment: A Report of Clinical Outcomes in an Asian Population. ( 29254601 )	Wadasadawala T....Sarin R.	2017
10	Bilateral Breast Cancer After Prophylactic Bilateral Pulmonary Irradiation. ( 28272005 )	El Meddeb H.A....Bouaouina N.	2017
11	Gastric metastasis of bilateral breast cancer. ( 28280631 )	Jmour O....Benna F.	2017
12	pCR rates in patients with bilateral breast cancer after neoadjuvant anthracycline-taxane based-chemotherapy - A retrospective pooled analysis of individual patients data of four German neoadjuvant trials. ( 28063331 )	Reinisch M....Loibl S.	2017
13	Synchronous Bilateral Breast Cancer With Discordant Histology. ( 28412779 )		2017
14	Treatment of bilateral breast cancer and regional nodes using an opposed lateral beam arrangement. ( 28867548 )		2017
15	Synchronous bilateral breast cancer irradiation: clinical and dosimetrical issues using volumetric modulated arc therapy and simultaneous integrated boost. ( 28224401 )		2017
16	Bilateral Breast Cancer with Neurofibromatosis Type 1 Patient: Case Report. ( 29082380 )		2017
17	PALB2 mutation in a woman with bilateral breast cancer: A case report. ( 28413668 )		2017
18	Femoral Placement of Totally Implantable Venous Access Ports in Patients with Bilateral Breast Cancer. ( 26855441 )	Almasi-Sperling V....Sagban T.A.	2016
19	Bilateral breast cancer resection performed under the bilateral transversus thoracic muscle plane block. ( 27555202 )	Ueshima H....Otake H.	2016
20	Image-guided intensity-modulated radiotherapy for refractory bilateral breast cancer in a patient with extensive cutaneous metastasis in the chest and abdominal walls. ( 27284253 )	Lu Y.F....Hsieh C.H.	2016
21	Unilateral Arm Urticaria Presenting as a Paraneoplastic Manifestation of Metachronous Bilateral Breast Cancer. ( 26933416 )	Kasi P.M....Haddad T.C.	2016
22	BILATERAL BREAST CANCER: DIAGNOSIS AND PROGNOSIS. ( 27483711 )		2016
23	Helical tomotherapy for bilateral breast cancer: Clinical experience. ( 27253152 )		2016
24	Challenges of treating incidental synchronous bilateral breast cancer with differing tumour biology. ( 27539136 )		2016
25	Co-existence of a giant cell tumour of the tendon sheath and schwannoma in a patient with bilateral breast cancer: A potential cause of false positive findings in (18)F-FDG PET/CT studies. ( 27329560 )		2016
26	Disease evolution and heterogeneity in bilateral breast cancer. ( 27904775 )	Fountzilas E...Fountzilas G	2016
27	EVOLUTION OF SYNCHRONOUS BILATERAL BREAST CARCINOMA IN A YOUNG PATIENT. ( 27125095 )	Manea E...Munteanu A	2016
28	Metabolic flare phenomenon on 18 fluoride-fluorodeoxy glucose positron emission tomography-computed tomography scans in a patient with bilateral breast cancer treated with second-line chemotherapy and bevacizumab. ( 25829734 )	Balasubramanian Harisankar C.N....John J.	2015
29	Bilateral breast cancer, synchronous and metachronous; differences and outcome. ( 26268697 )	Jobsen J.J....Struikmans H.	2015
30	A case of synchronous multiple bilateral breast cancer after breast augmentation. ( 26722625 )	Yamamoto S....Matsubara Y.	2015
31	Long-term effects of first degree family history of breast cancer in young women: Recurrences and bilateral breast cancer. ( 26399280 )	Jobsen J.J....Struikmans H.	2015
32	Coexistence of systemic lupus erythematosus, Hashimoto's thyroiditis, and bilateral breast cancer in the same patient: a random association? ( 26399842 )	Molinelli E....Offidani A.	2015
33	Impact of bilateral breast cancer on prognosis: synchronous versus metachronous tumors. ( 25735321 )	Ibrahim N.Y....Darwish D.O.	2015
34	Bilateral breast cancer following augmentation mammaplasty with polyacrylamide hydrogel injection: A case report. ( 26137129 )	Zhao Y....Zhao X.	2015
35	Surgical management for early-stage bilateral breast cancer patients in china. ( 25874699 )	Chen J.J....Wu J.	2015
36	Breast-Conserving Surgery in Bilateral Breast Cancer. ( 26265365 )	O'Brien J.A....Gemignani M.L.	2015
37	Use of tomotherapy in treatment of synchronous bilateral breast cancer: dosimetric comparison study. ( 25605345 )	Wadasadawala T....Phurailatpam R.	2015
38	Multifocal Bilateral Breast Cancer and Breast Follicular Lymphoma: A Simple Coincidence? ( 26472982 )		2015
39	Bilateral breast cancer with a unilateral carcinoma within a fibroadenoma: A case report. ( 26622700 )		2015
40	Bilateral breast cancer among three Yoruba women in a Nigerian teaching hospital. ( 30363615 )	Olubunmi Obajimi M...Akinwunmi OM	2015
41	Sarcoma of the breast and chest wall after radiation treatment for bilateral breast carcinoma. ( 25788453 )	Pradniwat K...Tan PH	2015
42	Properties of Synchronous Versus Metachronous Bilateral Breast Carcinoma with Long Time Follow Up. ( 26163616 )	Eliyatkin N...Aktas S	2015
43	Primary Squamous Cell Carcinoma of the Breast After Cured Bilateral Breast Cancer. ( 25398815 )	Porzio R....Cavanna L.	2014
44	Primary synchronous bilateral breast cancer. ( 25494117 )	Krishnappa R....Deshmane V.	2014
45	Morphoimmunohistochemical characteristics of synchronous bilateral breast cancer. ( 25257431 )	Todorov S.S....Nepomnyashchikh L.M.	2014
46	Prostate cancer in a man with a BRCA2 mutation and a personal history of bilateral breast cancer. ( 25112434 )		2014
47	A clinicopathological study of early-stage synchronous bilateral breast cancer: a retrospective evaluation and prospective validation of potential risk factors. ( 24736632 )		2014
48	A novel deleterious PTEN mutation in a patient with early-onset bilateral breast cancer. ( 24498881 )		2014
49	Prognosis of synchronous bilateral breast cancer: a review and meta-analysis of observational studies. ( 25007962 )		2014
50	Periductal stromal tumor of the breast with synchronous bilateral breast cancer. ( 24982380 )		2014

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Genes for Bilateral Breast Cancer

Genes related to Bilateral Breast Cancer (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	BRCA1	BRCA1, DNA Repair Associated	Protein Coding	35.92	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	11556836 10573018 17557253 (more) 19372713 8723683 15319244 10737987 9145677 19629752 8281142 19736894 19153073 11802208 11389159 11149425 20104584 10188893 19649703 16331614 12151349 9333265 7627958 11130383 19127556 19393826
2	BRCA2	BRCA2, DNA Repair Associated	Protein Coding	35.92	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	11556836 10573018 19649703 (more) 19372713 15319244 19127556 11793480 10699917 11389159 19153073 11802208 11149425 20104584 10188893 16331614 19288190 11130383 19698031
3	ATM	ATM Serine/Threonine Kinase	Protein Coding	30.3	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	19153073 12673797 14562025 (more) 15756685 18264724
4	CHEK2	Checkpoint Kinase 2	Protein Coding	30.2	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	19372713
5	RAD51	RAD51 Recombinase	Protein Coding	25.02	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	17666788 10807537
6	FHIT	Fragile Histidine Triad	Protein Coding	24.98	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	9157994
7	PGR	Progesterone Receptor	Protein Coding	22.56	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	7651928
8	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	22.49	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	PALB2	Partner And Localizer Of BRCA2	Protein Coding	21.3	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

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Variations for Bilateral Breast Cancer

ClinVar genetic disease variations for Bilateral Breast Cancer:

⁶

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	ATM	NM_000051.3(ATM): c.2021A> G (p.His674Arg)	single nucleotide variant	Uncertain significance	rs201762714	GRCh37	Chromosome 11, 108124663: 108124663
2	ATM	NM_000051.3(ATM): c.2021A> G (p.His674Arg)	single nucleotide variant	Uncertain significance	rs201762714	GRCh38	Chromosome 11, 108253936: 108253936

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Expression for Bilateral Breast Cancer

Search GEO for disease gene expression data for Bilateral Breast Cancer.

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Pathways for Bilateral Breast Cancer

Pathways related to Bilateral Breast Cancer according to GeneCards Suite gene sharing:

(show all 33)

#	Super pathways	Score	Top Affiliating Genes
1	Cell Cycle, Mitotic ⁶⁶ Show member pathways Cell Cycle ⁶⁶ M Phase ⁶⁶	13.2	ATM BRCA1 BRCA2 CHEK2 RAD51
2	DNA Double-Strand Break Repair ⁶⁶ Show member pathways Chk1/Chk2(Cds1) mediated inactivation of Cyclin B-Cdk1 complex ⁶⁶ DNA damage_DNA-damage-induced responses ²² DNA Repair ⁶⁶ G2/M DNA damage checkpoint ⁶⁶ HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) ⁶⁶ HDR through MMEJ (alt-NHEJ) ⁶⁶ Homology Directed Repair ⁶⁶ Non-homologous end joining ¹ Non-homologous end-joining ³⁷ Processing of DNA double-strand break ends ⁶⁶	13	ATM BRCA1 BRCA2 CHEK2 PALB2 RAD51
3	TCR Signaling (Qiagen) ⁶⁴ Show member pathways Fc-EpsilonRI Pathway ⁶⁴ ITK and TCR Signaling ⁶⁴ PDGF Pathway ⁶⁴ PKC-Theta Pathway ⁶⁴	12.74	ATM BRCA1 BRCA2 CHEK2 RAD51
4	Glioma ³⁷ Show member pathways EGFR tyrosine kinase inhibitor resistance ³⁷ Endocrine resistance ³⁷ Melanoma ³⁷ Non-small cell lung cancer ³⁷ Signaling Pathways in Glioblastoma ¹	12.58	ATM BRCA1 BRCA2 ERBB2 FHIT
5	Gastric cancer ³⁷ Show member pathways Breast cancer ³⁷ Hepatocellular carcinoma ³⁷	12.56	BRCA1 BRCA2 ERBB2 PGR
6	Chks in Checkpoint Regulation ⁶⁴ Show member pathways DNA Repair Mechanisms ⁶⁴ Estrogen-mediated S-Phase Entry ⁶⁴ G2-M Phase Transition ⁶⁴ Parkinson's Disease Pathway ⁶⁴ SREBP Proteolysis ⁶⁴	12.5	ATM BRCA1 BRCA2 CHEK2 RAD51
7	Meiosis ⁶⁶ Show member pathways Meiotic recombination ⁶⁶ Meiotic synapsis ⁶⁶	12.35	ATM BRCA1 BRCA2 RAD51
8	DNA Damage ⁴	12.33	ATM BRCA1 BRCA2 CHEK2 RAD51
9	MicroRNAs in cancer ³⁷	12.31	ATM BRCA1 ERBB2
10	Apoptosis Pathway ⁷² Show member pathways Akt Pathway ⁷² NF-kappaB Pathway ⁷²	12.24	ATM CHEK2 ERBB2
11	DNA Damage Response ¹ Show member pathways miRNA Regulation of DNA Damage Response ¹ p53 signaling pathway ³⁷	12.23	ATM BRCA1 CHEK2 RAD51
12	DNA Double Strand Break Response ⁶⁶ Show member pathways Nonhomologous End-Joining (NHEJ) ⁶⁶ Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks ⁶⁶ Sensing of DNA Double Strand Breaks ⁶⁶	12.17	ATM BRCA1 CHEK2
13	p53 Signaling ⁶⁴ Show member pathways p53 Pathway ⁶⁷	12.06	ATM BRCA1 CHEK2
14	Cell cycle Role of SCF complex in cell cycle regulation ²² Show member pathways Cell cycle ESR1 regulation of G1/S transition ²² Cell cycle Regulation of G1/S transition (part 1) ²² Immune response MIF-JAB1 signaling ²²	12.03	BRCA1 CHEK2 PGR
15	Homologous DNA Pairing and Strand Exchange ⁶⁶ Show member pathways ATR Signaling ¹ HDR through Homologous Recombination (HRR) ⁶⁶ HDR through Single Strand Annealing (SSA) ⁶⁶ Presynaptic phase of homologous DNA pairing and strand exchange ⁶⁶	12.02	ATM BRCA1 BRCA2 PALB2 RAD51
16	Integrated Breast Cancer Pathway ¹	11.74	ATM BRCA1 BRCA2 CHEK2 RAD51
17	Fanconi anemia pathway ³⁷ ⁶⁶	11.71	BRCA1 BRCA2 PALB2 RAD51
18	ATM Pathway ⁶⁴ Show member pathways ATM Signaling Pathway ¹	11.64	ATM BRCA1 CHEK2 RAD51
19	Platinum drug resistance ³⁷	11.62	ATM BRCA1 ERBB2
20	Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) ⁶⁶ Show member pathways Homologous recombination ³⁷ Homologous recombination ¹ Resolution of D-Loop Structures ⁶⁶ Resolution of D-loop Structures through Holliday Junction Intermediates ⁶⁶	11.54	ATM BRCA1 BRCA2 PALB2 RAD51
21	Pathways Affected in Adenoid Cystic Carcinoma ¹	11.49	ATM BRCA1 CHEK2 ERBB2
22	Integrated Cancer Pathway ¹	11.39	ATM BRCA1 CHEK2
23	DNA damage_ATM/ATR regulation of G1/S checkpoint ²²	11.36	ATM BRCA1 CHEK2
24	ATM Signaling Network in Development and Disease ¹	11.32	ATM CHEK2
25	Cell cycle Role of 14-3-3 proteins in cell cycle regulation ²² Show member pathways 14-3-3 and Cell Cycle Regulation ⁶⁴	11.3	ATM CHEK2
26	DNA damage_Role of Brca1 and Brca2 in DNA repair ²²	11.26	ATM BRCA1 BRCA2 CHEK2 RAD51
27	FOXM1 transcription factor network ¹	11.21	BRCA2 CHEK2
28	GADD45 Pathway ⁶⁴	11.13	ATM BRCA1
29	Ovarian Infertility Genes ¹	11.13	ATM PGR
30	BARD1 signaling events ¹	11.12	ATM BRCA1 RAD51
31	Gemtuzumab ozogamicin Pathway, Pharmacokinetics/Pharmacodynamics ⁶¹	10.98	ATM CHEK2
32	BRCA1 Pathway ⁶⁴ Show member pathways Fanconi's Anaemia Pathway ⁶⁴	10.94	ATM BRCA1 BRCA2 CHEK2 RAD51
33	DNA Damage Induced 14-3-3Sigma Signaling ⁶⁴	10.88	ATM BRCA1

Sources

GO Terms for Bilateral Breast Cancer

Cellular components related to Bilateral Breast Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nucleoplasm	GO:0005654	9.8	ATM BRCA1 BRCA2 CHEK2 PALB2 PGR
2	nucleus	GO:0005634	9.61	ATM BRCA1 BRCA2 CHEK2 ERBB2 FHIT
3	condensed nuclear chromosome	GO:0000794	9.37	BRCA1 RAD51
4	nuclear chromosome, telomeric region	GO:0000784	9.33	ATM BRCA2 RAD51
5	condensed chromosome	GO:0000793	9.32	BRCA1 RAD51
6	lateral element	GO:0000800	8.8	BRCA1 BRCA2 RAD51
7	cytoplasm	GO:0005737	10.01	ATM BRCA1 BRCA2 CHEK2 ERBB2 FHIT

Biological processes related to Bilateral Breast Cancer according to GeneCards Suite gene sharing:

(show all 26)

#	Name	GO ID	Score	Top Affiliating Genes
1	apoptotic process	GO:0006915	9.91	ATM BRCA1 CHEK2 FHIT
2	cell cycle	GO:0007049	9.87	ATM BRCA1 BRCA2 CHEK2
3	protein autophosphorylation	GO:0046777	9.72	ATM CHEK2 ERBB2
4	DNA recombination	GO:0006310	9.67	BRCA1 BRCA2 PALB2 RAD51
5	positive regulation of cell adhesion	GO:0045785	9.63	ATM ERBB2
6	double-strand break repair	GO:0006302	9.63	BRCA1 BRCA2 CHEK2
7	cellular response to DNA damage stimulus	GO:0006974	9.63	ATM BRCA1 BRCA2 CHEK2 PALB2 RAD51
8	response to ionizing radiation	GO:0010212	9.62	ATM BRCA1
9	negative regulation of G0 to G1 transition	GO:0070317	9.62	BRCA1 RAD51
10	double-strand break repair via homologous recombination	GO:0000724	9.62	BRCA1 BRCA2 PALB2 RAD51
11	mammary gland development	GO:0030879	9.61	BRCA2 PGR
12	DNA damage checkpoint	GO:0000077	9.6	ATM CHEK2
13	reciprocal meiotic recombination	GO:0007131	9.59	ATM RAD51
14	response to gamma radiation	GO:0010332	9.58	BRCA2 CHEK2
15	cellular response to gamma radiation	GO:0071480	9.58	ATM CHEK2
16	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	GO:0042771	9.56	BRCA2 CHEK2
17	DNA double-strand break processing	GO:0000729	9.54	ATM BRCA1
18	replicative senescence	GO:0090399	9.52	ATM CHEK2
19	inner cell mass cell proliferation	GO:0001833	9.51	BRCA2 PALB2
20	telomere maintenance via recombination	GO:0000722	9.49	BRCA2 RAD51
21	DNA damage induced protein phosphorylation	GO:0006975	9.48	ATM CHEK2
22	chordate embryonic development	GO:0043009	9.43	BRCA1 BRCA2
23	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO:0006978	9.43	BRCA1 BRCA2 CHEK2
24	mitotic recombination-dependent replication fork processing	GO:1990426	9.4	BRCA2 RAD51
25	intrinsic apoptotic signaling pathway in response to DNA damage	GO:0008630	9.26	ATM BRCA1 BRCA2 CHEK2
26	DNA repair	GO:0006281	9.1	ATM BRCA1 BRCA2 CHEK2 PALB2 RAD51

Molecular functions related to Bilateral Breast Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	DNA binding	GO:0003677	9.63	ATM BRCA1 BRCA2 PALB2 PGR RAD51
2	ubiquitin protein ligase binding	GO:0031625	9.5	BRCA1 CHEK2 FHIT
3	protein C-terminus binding	GO:0008022	9.43	BRCA2 ERBB2 RAD51
4	nucleotide binding	GO:0000166	9.35	ATM CHEK2 ERBB2 FHIT RAD51
5	identical protein binding	GO:0042802	9.17	BRCA1 BRCA2 CHEK2 ERBB2 FHIT PGR
6	protein binding	GO:0005515	10.02	ATM BRCA1 BRCA2 CHEK2 ERBB2 FHIT

Sources

Sources for Bilateral Breast Cancer

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia