MCID: BLT006
MIFTS: 48

Bilateral Breast Cancer

Categories: Cancer diseases

Aliases & Classifications for Bilateral Breast Cancer

MalaCards integrated aliases for Bilateral Breast Cancer:

Name: Bilateral Breast Cancer 12 56 15 74
Bilateral Breast Carcinoma 12 30 6

Classifications:



External Ids:

Disease Ontology 12 DOID:6741
NCIt 51 C8287
UMLS 74 C0281267

Summaries for Bilateral Breast Cancer

Disease Ontology : 12 A breast carcinoma that is characterized by an individual having breast cancer in both breasts, either simultaneously or at different times.

MalaCards based summary : Bilateral Breast Cancer, also known as bilateral breast carcinoma, is related to synchronous bilateral breast carcinoma and papillary serous adenocarcinoma. An important gene associated with Bilateral Breast Cancer is BRCA2 (BRCA2 DNA Repair Associated), and among its related pathways/superpathways are Cell Cycle, Mitotic and DNA Double-Strand Break Repair. The drugs Trastuzumab and Paclitaxel have been mentioned in the context of this disorder. Affiliated tissues include breast, bone and lung, and related phenotypes are Decreased homologous recombination repair frequency and Decreased homologous recombination repair frequency

Related Diseases for Bilateral Breast Cancer

Diseases related to Bilateral Breast Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 141)
# Related Disease Score Top Affiliating Genes
1 synchronous bilateral breast carcinoma 33.4 ATM BRCA1 BRCA2 PGR
2 papillary serous adenocarcinoma 29.9 BRCA1 PGR
3 ataxia-telangiectasia 29.7 ATM BRCA1 CHEK2
4 mammary paget's disease 29.5 ERBB2 PGR
5 li-fraumeni syndrome 29.5 ATM BRCA1 BRCA2 CHEK2
6 in situ carcinoma 29.4 BRCA1 ERBB2 PGR
7 ductal carcinoma in situ 29.1 BRCA1 BRCA2 ERBB2 PGR
8 breast cancer 28.7 ATM BRCA1 BRCA2 CHEK2 ERBB2 FHIT
9 ovarian cancer 27.8 ATM BRCA1 BRCA2 CHEK2 ERBB2 PALB2
10 sporadic breast cancer 27.6 ATM BRCA1 BRCA2 CHEK2 ERBB2 FHIT
11 hereditary site-specific ovarian cancer syndrome 10.3 BRCA1 BRCA2
12 breast reconstruction 10.3 BRCA1 BRCA2
13 breast-ovarian cancer, familial 1 10.3 BRCA1 BRCA2
14 premature menopause 10.3 BRCA1 BRCA2
15 fallopian tube disease 10.3 BRCA1 BRCA2
16 lynch syndrome i 10.2 BRCA1 BRCA2
17 mutagen sensitivity 10.2 BRCA1 BRCA2
18 fanconi anemia, complementation group u 10.2 BRCA1 RAD51
19 fanconi anemia, complementation group d2 10.2 BRCA2 RAD51
20 clivus chordoma 10.2 ATM CHEK2
21 fanconi anemia, complementation group v 10.2 BRCA1 RAD51
22 sulfite oxidase deficiency due to molybdenum cofactor deficiency 10.2
23 uterine corpus serous adenocarcinoma 10.1 BRCA1 ERBB2
24 corneal abscess 10.1 PGR RAD51
25 fanconi anemia, complementation group r 10.1 BRCA1 RAD51
26 lobular neoplasia 10.1 BRCA1 ERBB2
27 fanconi anemia, complementation group t 10.1 BRCA1 RAD51
28 congenital hypoplastic anemia 10.1 BRCA2 RAD51
29 fanconi anemia, complementation group q 10.1 BRCA1 BRCA2 RAD51
30 nijmegen breakage syndrome 10.1 ATM BRCA1 CHEK2
31 t-cell prolymphocytic leukemia 10.1 ATM CHEK2
32 scirrhous adenocarcinoma 10.1 ERBB2 PGR
33 breast apocrine carcinoma 10.1 ERBB2 PGR
34 glassy cell carcinoma of the cervix 10.1 ERBB2 PGR
35 tracheoesophageal fistula with or without esophageal atresia 10.1 BRCA2 PALB2
36 nosophobia 10.1 BRCA1 BRCA2 PGR
37 cancerophobia 10.1 BRCA1 BRCA2 PGR
38 tracheoesophageal fistula 10.1 BRCA2 PALB2
39 isolated tracheoesophageal fistula 10.1 BRCA2 PALB2
40 intracystic papillary adenoma 10.0 ERBB2 PGR
41 glycogen-rich clear cell breast carcinoma 10.0 BRCA1 BRCA2 PGR
42 breast metaplastic carcinoma 10.0 ERBB2 PGR
43 progesterone-receptor negative breast cancer 10.0 ERBB2 PGR
44 breast scirrhous carcinoma 10.0 ERBB2 PGR
45 dysgerminoma of ovary 10.0 BRCA1 BRCA2 PGR
46 progesterone-receptor positive breast cancer 10.0 ERBB2 PGR
47 apocrine adenocarcinoma 10.0 ERBB2 PGR
48 fanconi anemia, complementation group n 10.0 BRCA2 PALB2
49 uterine body mixed cancer 10.0 ERBB2 PGR
50 breast adenoid cystic carcinoma 10.0 ERBB2 PGR

Graphical network of the top 20 diseases related to Bilateral Breast Cancer:



Diseases related to Bilateral Breast Cancer

Symptoms & Phenotypes for Bilateral Breast Cancer

GenomeRNAi Phenotypes related to Bilateral Breast Cancer according to GeneCards Suite gene sharing:

27 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased homologous recombination repair frequency GR00151-A-1 10.83 BRCA1 RAD51
2 Decreased homologous recombination repair frequency GR00151-A-2 10.83 BRCA1 RAD51
3 Decreased homologous recombination repair frequency GR00236-A-1 10.83 BRCA1 BRCA2 PALB2 PGR RAD51
4 Decreased homologous recombination repair frequency GR00236-A-2 10.83 BRCA1 BRCA2 PALB2 PGR RAD51 ATM
5 Decreased homologous recombination repair frequency GR00236-A-3 10.83 BRCA1 BRCA2 PALB2 RAD51
6 Decreased viability GR00221-A-2 10.24 BRCA1 CHEK2
7 Decreased viability GR00221-A-3 10.24 ATM BRCA1 CHEK2 ERBB2
8 Decreased viability GR00221-A-4 10.24 ATM CHEK2 ERBB2
9 Decreased viability GR00301-A 10.24 BRCA1
10 Decreased viability GR00342-S-2 10.24 CHEK2
11 Decreased viability GR00402-S-2 10.24 ATM BRCA1 CHEK2 ERBB2
12 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.64 ATM BRCA1 BRCA2 CHEK2 PALB2
13 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.64 ATM BRCA1 BRCA2 CHEK2 PALB2 RAD51
14 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.63 ATM BRCA1 BRCA2 CHEK2 PALB2 RAD51
15 Decreased viability after ionizing radiation GR00232-A-2 9.5 ATM BRCA1 BRCA2
16 Decreased viability with cisplatin GR00101-A-4 9.43 BRCA1 BRCA2 RAD51
17 Synthetic lethal with cisplatin GR00101-A-1 9.13 BRCA1 BRCA2 RAD51

MGI Mouse Phenotypes related to Bilateral Breast Cancer:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.01 ATM BRCA1 BRCA2 CHEK2 ERBB2 PALB2
2 embryo MP:0005380 9.91 ATM BRCA1 BRCA2 ERBB2 PALB2 PGR
3 endocrine/exocrine gland MP:0005379 9.8 ATM BRCA1 BRCA2 CHEK2 ERBB2 PGR
4 integument MP:0010771 9.8 ATM BRCA1 BRCA2 ERBB2 FHIT PALB2
5 mortality/aging MP:0010768 9.61 ATM BRCA1 BRCA2 CHEK2 ERBB2 FHIT
6 limbs/digits/tail MP:0005371 9.55 BRCA1 BRCA2 ERBB2 PALB2 PGR
7 neoplasm MP:0002006 9.23 ATM BRCA1 BRCA2 CHEK2 ERBB2 FHIT

Drugs & Therapeutics for Bilateral Breast Cancer

Drugs for Bilateral Breast Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 63)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Trastuzumab Approved, Investigational Phase 3 180288-69-1 9903
2
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
3
Atezolizumab Approved, Investigational Phase 3 1380723-44-3
4
Carboplatin Approved Phase 3 41575-94-4 38904 10339178 498142
5
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 6055-19-2, 50-18-0 2907
6
Pertuzumab Approved Phase 3 380610-27-5, 145040-37-5 2540
7
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
8
Exemestane Approved, Investigational Phase 3 107868-30-4 60198
9
Tamoxifen Approved Phase 3 10540-29-1 2733526
10
Anastrozole Approved, Investigational Phase 3 120511-73-1 2187
11
Sodium Citrate Approved, Investigational Phase 3 68-04-2
12
Letrozole Approved, Investigational Phase 3 112809-51-5 3902
13
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
14
Citric Acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
15
Doxil Approved June 1999 Phase 3 31703
16 Immunoglobulins Phase 3
17 Anti-Bacterial Agents Phase 3
18 Antineoplastic Agents, Alkylating Phase 3,Phase 2
19 Antibodies, Monoclonal Phase 3
20 Antineoplastic Agents, Immunological Phase 3
21 Immunosuppressive Agents Phase 3,Phase 2
22 Antibodies Phase 3
23 Immunologic Factors Phase 3,Phase 2
24 Topoisomerase Inhibitors Phase 3
25 Albumin-Bound Paclitaxel Phase 3
26 Alkylating Agents Phase 3,Phase 2
27 Antibiotics, Antitubercular Phase 3
28 Antimitotic Agents Phase 3,Phase 2
29 Antineoplastic Agents, Phytogenic Phase 3
30 Antirheumatic Agents Phase 3,Phase 2
31 Estrogen Receptor Modulators Phase 3
32 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
33 Estrogens Phase 3
34 Calcium, Dietary Phase 3
35 Anticoagulants Phase 3
36 Citrate Phase 3
37 Selective Estrogen Receptor Modulators Phase 3
38 Antineoplastic Agents, Hormonal Phase 3
39 Hormone Antagonists Phase 3
40 Steroid Synthesis Inhibitors Phase 3
41 Chelating Agents Phase 3
42 Estrogen Antagonists Phase 3
43 Hormones Phase 3
44 Aromatase Inhibitors Phase 3
45 Estrogen Receptor Antagonists Phase 3
46 Bone Density Conservation Agents Phase 3
47
Sargramostim Approved, Investigational Phase 2 123774-72-1, 83869-56-1
48
leucovorin Approved Phase 2 58-05-9 6006 143
49
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
50
Emodepside Investigational, Vet_approved Phase 2 155030-63-0

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Neoadjuvant Treatment of HER2 Positive Early High-risk and Locally Advanced Breast Cancer Recruiting NCT03595592 Phase 3 Trastuzumab;Pertuzumab;Carboplatin;Paclitaxel;Doxorubicin;Cyclophosphamide;Atezolizumab
2 Tamoxifen Citrate, Letrozole, Anastrozole, or Exemestane With or Without Chemotherapy in Treating Patients With Invasive RxPONDER Breast Cancer Active, not recruiting NCT01272037 Phase 3 Anastrozole;Exemestane;Letrozole;Systemic Chemotherapy;Tamoxifen Citrate
3 Multi-epitope Folate Receptor Alpha Peptide Vaccine, Sargramostim, and Cyclophosphamide in Treating Patients With Triple Negative Breast Cancer Recruiting NCT03012100 Phase 2 Cyclophosphamide
4 Ixabepilone in Treating Participants With Significant Residual Disease of HER2/Neu Negative Invasive Breast Cancer After Systemic Therapy Active, not recruiting NCT00877500 Phase 2 Ixabepilone
5 Pre-operative Magnetic Resonance Imaging (MRI) in Young Breast Cancer Patients Unknown status NCT00801476 Not Applicable
6 EMG at Performing ULTN 1 in Breast Cancer Patients Completed NCT02599467 Not Applicable
7 Study of Radiation Exposure and Bilateral Breast Cancer Active, not recruiting NCT00903591
8 Genetic Counseling for Breast Cancer Survivors (GC for BC) Active, not recruiting NCT02451735 Not Applicable

Search NIH Clinical Center for Bilateral Breast Cancer

Genetic Tests for Bilateral Breast Cancer

Genetic tests related to Bilateral Breast Cancer:

# Genetic test Affiliating Genes
1 Bilateral Breast Carcinoma 30

Anatomical Context for Bilateral Breast Cancer

MalaCards organs/tissues related to Bilateral Breast Cancer:

42
Breast, Bone, Lung, Prostate, Thyroid, Lymph Node, Small Intestine

Publications for Bilateral Breast Cancer

Articles related to Bilateral Breast Cancer:

(show top 50) (show all 251)
# Title Authors Year
1
Body mass index and diabetes are important prognostic signatures for bilateral breast cancer prognosis. ( 30618092 )
2019
2
Bilateral erector spinae nerve block using one injection for bilateral breast cancer surgery. ( 30776776 )
2019
3
Breast cancer mortality in synchronous bilateral breast cancer patients. ( 30804429 )
2019
4
Skin and lung toxicity in synchronous bilateral breast cancer treated with volumetric-modulated arc radiotherapy: a mono-institutional experience. ( 30875061 )
2019
5
Sequential Sentinel Node Scintigraphy With Planar and SPECT/CT Images Revealed Contralateral Drainage From Ipsilateral Breast Tumor Relapse in a Patient With Bilateral Breast Cancer. ( 29659396 )
2018
6
Including internal mammary lymph nodes in radiation therapy for synchronous bilateral breast cancer: an international survey of treatment technique and clinical priorities. ( 29869775 )
2018
7
Delayed Recurrent and Bilateral Breast Cancer in Patients With Partial Poland's Anomaly: Report of 2 Rare Cases and Review of the Literature. ( 29475749 )
2018
8
Dissecting Time- from Tumor-Related Gene Expression Variability in Bilateral Breast Cancer. ( 29315233 )
2018
9
Synchronous bilateral breast cancer patients submitted to conservative treatment and brachytherapy - The experience of a service. ( 30127671 )
2018
10
Synchronous bilateral breast cancer: A case report of heterogeneous estrogen receptor status. ( 30391732 )
2018
11
Favorable progression-free survival in women with two different histopathological subtypes of bilateral breast cancer. ( 30589050 )
2018
12
Synchronous and metachronous bilateral breast cancer: A long-term experience. ( 30610782 )
2018
13
First clinical report of helical tomotherapy with simultaneous integrated boost for synchronous bilateral breast cancer. ( 28707988 )
2017
14
Synchronous Bilateral Breast Cancer in a Patient With Nager Syndrome. ( 28139434 )
2017
15
Bilateral Breast Cancer After Multimodality Treatment: A Report of Clinical Outcomes in an Asian Population. ( 29254601 )
2017
16
Bilateral Breast Cancer After Prophylactic Bilateral Pulmonary Irradiation. ( 28272005 )
2017
17
Gastric metastasis of bilateral breast cancer. ( 28280631 )
2017
18
pCR rates in patients with bilateral breast cancer after neoadjuvant anthracycline-taxane based-chemotherapy - A retrospective pooled analysis of individual patients data of four German neoadjuvant trials. ( 28063331 )
2017
19
Synchronous Bilateral Breast Cancer With Discordant Histology. ( 28412779 )
2017
20
Treatment of bilateral breast cancer and regional nodes using an opposed lateral beam arrangement. ( 28867548 )
2017
21
Synchronous bilateral breast cancer irradiation: clinical and dosimetrical issues using volumetric modulated arc therapy and simultaneous integrated boost. ( 28224401 )
2017
22
Bilateral Breast Cancer with Neurofibromatosis Type 1 Patient: Case Report. ( 29082380 )
2017
23
PALB2 mutation in a woman with bilateral breast cancer: A case report. ( 28413668 )
2017
24
Femoral Placement of Totally Implantable Venous Access Ports in Patients with Bilateral Breast Cancer. ( 26855441 )
2016
25
Bilateral breast cancer resection performed under the bilateral transversus thoracic muscle plane block. ( 27555202 )
2016
26
Image-guided intensity-modulated radiotherapy for refractory bilateral breast cancer in a patient with extensive cutaneous metastasis in the chest and abdominal walls. ( 27284253 )
2016
27
Unilateral Arm Urticaria Presenting as a Paraneoplastic Manifestation of Metachronous Bilateral Breast Cancer. ( 26933416 )
2016
28
BILATERAL BREAST CANCER: DIAGNOSIS AND PROGNOSIS. ( 27483711 )
2016
29
Helical tomotherapy for bilateral breast cancer: Clinical experience. ( 27253152 )
2016
30
Challenges of treating incidental synchronous bilateral breast cancer with differing tumour biology. ( 27539136 )
2016
31
Co-existence of a giant cell tumour of the tendon sheath and schwannoma in a patient with bilateral breast cancer: A potential cause of false positive findings in (18)F-FDG PET/CT studies. ( 27329560 )
2016
32
Disease evolution and heterogeneity in bilateral breast cancer. ( 27904775 )
2016
33
Metabolic flare phenomenon on 18 fluoride-fluorodeoxy glucose positron emission tomography-computed tomography scans in a patient with bilateral breast cancer treated with second-line chemotherapy and bevacizumab. ( 25829734 )
2015
34
Bilateral breast cancer, synchronous and metachronous; differences and outcome. ( 26268697 )
2015
35
A case of synchronous multiple bilateral breast cancer after breast augmentation. ( 26722625 )
2015
36
Long-term effects of first degree family history of breast cancer in young women: Recurrences and bilateral breast cancer. ( 26399280 )
2015
37
Coexistence of systemic lupus erythematosus, Hashimoto's thyroiditis, and bilateral breast cancer in the same patient: a random association? ( 26399842 )
2015
38
Impact of bilateral breast cancer on prognosis: synchronous versus metachronous tumors. ( 25735321 )
2015
39
Bilateral breast cancer following augmentation mammaplasty with polyacrylamide hydrogel injection: A case report. ( 26137129 )
2015
40
Surgical management for early-stage bilateral breast cancer patients in china. ( 25874699 )
2015
41
Breast-Conserving Surgery in Bilateral Breast Cancer. ( 26265365 )
2015
42
Use of tomotherapy in treatment of synchronous bilateral breast cancer: dosimetric comparison study. ( 25605345 )
2015
43
Multifocal Bilateral Breast Cancer and Breast Follicular Lymphoma: A Simple Coincidence? ( 26472982 )
2015
44
Bilateral breast cancer with a unilateral carcinoma within a fibroadenoma: A case report. ( 26622700 )
2015
45
Bilateral breast cancer among three Yoruba women in a Nigerian teaching hospital. ( 30363615 )
2015
46
Properties of Synchronous Versus Metachronous Bilateral Breast Carcinoma with Long Time Follow Up. ( 26163616 )
2015
47
Sarcoma of the breast and chest wall after radiation treatment for bilateral breast carcinoma. ( 25788453 )
2015
48
Primary Squamous Cell Carcinoma of the Breast After Cured Bilateral Breast Cancer. ( 25398815 )
2014
49
Primary synchronous bilateral breast cancer. ( 25494117 )
2014
50
Morphoimmunohistochemical characteristics of synchronous bilateral breast cancer. ( 25257431 )
2014

Variations for Bilateral Breast Cancer

ClinVar genetic disease variations for Bilateral Breast Cancer:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 ATM NM_000051.3(ATM): c.2021A> G (p.His674Arg) single nucleotide variant Uncertain significance rs201762714 GRCh37 Chromosome 11, 108124663: 108124663
2 ATM NM_000051.3(ATM): c.2021A> G (p.His674Arg) single nucleotide variant Uncertain significance rs201762714 GRCh38 Chromosome 11, 108253936: 108253936

Expression for Bilateral Breast Cancer

Search GEO for disease gene expression data for Bilateral Breast Cancer.

Pathways for Bilateral Breast Cancer

Pathways related to Bilateral Breast Cancer according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.2 ATM BRCA1 BRCA2 CHEK2 RAD51
2
Show member pathways
13 ATM BRCA1 BRCA2 CHEK2 PALB2 RAD51
3
Show member pathways
12.74 ATM BRCA1 BRCA2 CHEK2 RAD51
4
Show member pathways
12.56 BRCA1 BRCA2 ERBB2 PGR
5
Show member pathways
12.5 ATM BRCA1 BRCA2 ERBB2 FHIT
6
Show member pathways
12.5 ATM BRCA1 BRCA2 CHEK2 RAD51
7
Show member pathways
12.35 ATM BRCA1 BRCA2 RAD51
8 12.33 ATM BRCA1 BRCA2 CHEK2 RAD51
9 12.31 ATM BRCA1 ERBB2
10
Show member pathways
12.24 ATM CHEK2 ERBB2
11
Show member pathways
12.23 ATM BRCA1 CHEK2 RAD51
12
Show member pathways
12.17 ATM BRCA1 CHEK2
13
Show member pathways
12.06 ATM BRCA1 CHEK2
14
Show member pathways
12.03 BRCA1 CHEK2 PGR
15
Show member pathways
12.02 ATM BRCA1 BRCA2 PALB2 RAD51
16 11.74 ATM BRCA1 BRCA2 CHEK2 RAD51
17 11.71 BRCA1 BRCA2 PALB2 RAD51
18
Show member pathways
11.64 ATM BRCA1 CHEK2 RAD51
19 11.62 ATM BRCA1 ERBB2
20
Show member pathways
11.54 ATM BRCA1 BRCA2 PALB2 RAD51
21 11.49 ATM BRCA1 CHEK2 ERBB2
22 11.39 ATM BRCA1 CHEK2
23 11.36 ATM BRCA1 CHEK2
24 11.32 ATM CHEK2
25
Show member pathways
11.3 ATM CHEK2
26 11.26 ATM BRCA1 BRCA2 CHEK2 RAD51
27 11.21 BRCA2 CHEK2
28 11.13 ATM BRCA1
29 11.13 ATM PGR
30 11.12 ATM BRCA1 RAD51
31 10.98 ATM CHEK2
32
Show member pathways
10.94 ATM BRCA1 BRCA2 CHEK2 RAD51
33 10.88 ATM BRCA1

GO Terms for Bilateral Breast Cancer

Cellular components related to Bilateral Breast Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.8 ATM BRCA1 BRCA2 CHEK2 PALB2 PGR
2 nucleus GO:0005634 9.61 ATM BRCA1 BRCA2 CHEK2 ERBB2 FHIT
3 condensed nuclear chromosome GO:0000794 9.37 BRCA1 RAD51
4 nuclear chromosome, telomeric region GO:0000784 9.33 ATM BRCA2 RAD51
5 condensed chromosome GO:0000793 9.32 BRCA1 RAD51
6 lateral element GO:0000800 8.8 BRCA1 BRCA2 RAD51
7 cytoplasm GO:0005737 10.01 ATM BRCA1 BRCA2 CHEK2 ERBB2 FHIT

Biological processes related to Bilateral Breast Cancer according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.91 ATM BRCA1 CHEK2 FHIT
2 cell cycle GO:0007049 9.87 ATM BRCA1 BRCA2 CHEK2
3 protein autophosphorylation GO:0046777 9.72 ATM CHEK2 ERBB2
4 DNA recombination GO:0006310 9.67 BRCA1 BRCA2 PALB2 RAD51
5 positive regulation of cell adhesion GO:0045785 9.63 ATM ERBB2
6 double-strand break repair GO:0006302 9.63 BRCA1 BRCA2 CHEK2
7 cellular response to DNA damage stimulus GO:0006974 9.63 ATM BRCA1 BRCA2 CHEK2 PALB2 RAD51
8 response to ionizing radiation GO:0010212 9.62 ATM BRCA1
9 negative regulation of G0 to G1 transition GO:0070317 9.62 BRCA1 RAD51
10 double-strand break repair via homologous recombination GO:0000724 9.62 BRCA1 BRCA2 PALB2 RAD51
11 DNA damage checkpoint GO:0000077 9.6 ATM CHEK2
12 reciprocal meiotic recombination GO:0007131 9.59 ATM RAD51
13 response to gamma radiation GO:0010332 9.58 BRCA2 CHEK2
14 cellular response to gamma radiation GO:0071480 9.58 ATM CHEK2
15 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.56 BRCA2 CHEK2
16 DNA double-strand break processing GO:0000729 9.54 ATM BRCA1
17 replicative senescence GO:0090399 9.52 ATM CHEK2
18 inner cell mass cell proliferation GO:0001833 9.51 BRCA2 PALB2
19 telomere maintenance via recombination GO:0000722 9.49 BRCA2 RAD51
20 DNA damage induced protein phosphorylation GO:0006975 9.48 ATM CHEK2
21 chordate embryonic development GO:0043009 9.43 BRCA1 BRCA2
22 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.43 BRCA1 BRCA2 CHEK2
23 mitotic recombination-dependent replication fork processing GO:1990426 9.4 BRCA2 RAD51
24 mammary gland development GO:0030879 9.31 PGR
25 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.26 ATM BRCA1 BRCA2 CHEK2
26 DNA repair GO:0006281 9.1 ATM BRCA1 BRCA2 CHEK2 PALB2 RAD51

Molecular functions related to Bilateral Breast Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.63 ATM BRCA1 BRCA2 PALB2 PGR RAD51
2 ubiquitin protein ligase binding GO:0031625 9.5 BRCA1 CHEK2 FHIT
3 protein C-terminus binding GO:0008022 9.43 BRCA2 ERBB2 RAD51
4 nucleotide binding GO:0000166 9.35 ATM CHEK2 ERBB2 FHIT RAD51
5 identical protein binding GO:0042802 9.17 BRCA1 BRCA2 CHEK2 ERBB2 FHIT PGR
6 protein binding GO:0005515 10.02 ATM BRCA1 BRCA2 CHEK2 ERBB2 FHIT

Sources for Bilateral Breast Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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