MCID: BLT006
MIFTS: 48

Bilateral Breast Cancer

Categories: Cancer diseases

Aliases & Classifications for Bilateral Breast Cancer

MalaCards integrated aliases for Bilateral Breast Cancer:

Name: Bilateral Breast Cancer 12 55 15 73
Bilateral Breast Carcinoma 12 29 6

Classifications:



External Ids:

Disease Ontology 12 DOID:6741
NCIt 50 C8287
UMLS 73 C0281267

Summaries for Bilateral Breast Cancer

Disease Ontology : 12 A breast carcinoma that is characterized by an individual having breast cancer in both breasts, either simultaneously or at different times.

MalaCards based summary : Bilateral Breast Cancer, also known as bilateral breast carcinoma, is related to synchronous bilateral breast carcinoma and ataxia-telangiectasia. An important gene associated with Bilateral Breast Cancer is BRCA1 (BRCA1, DNA Repair Associated), and among its related pathways/superpathways are Gene Expression and Cell Cycle, Mitotic. The drugs Anastrozole and Exemestane have been mentioned in the context of this disorder. Affiliated tissues include breast, bone and prostate, and related phenotypes are Decreased homologous recombination repair frequency and Decreased homologous recombination repair frequency

Related Diseases for Bilateral Breast Cancer

Diseases related to Bilateral Breast Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 165)
# Related Disease Score Top Affiliating Genes
1 synchronous bilateral breast carcinoma 31.5 ATM BRCA1 BRCA2 ESR1 PGR
2 ataxia-telangiectasia 29.7 ATM BRCA1 CHEK2
3 papillary serous adenocarcinoma 29.5 BRCA1 PGR
4 li-fraumeni syndrome 29.2 ATM BRCA1 BRCA2 CHEK2
5 breast squamous cell carcinoma 29.0 ERBB2 PGR
6 gynecomastia 28.5 ESR1 PGR
7 prostate cancer 27.8 BRCA1 BRCA2 CHEK2 ERBB2 ESR1
8 ductal carcinoma in situ 27.1 BRCA1 BRCA2 ERBB2 ESR1 PGR
9 ovarian cancer 25.7 ATM BRCA1 BRCA2 CHEK2 ERBB2 ESR1
10 breast cancer 25.6 ATM BRCA1 BRCA2 CHEK2 ERBB2 ESR1
11 sporadic breast cancer 24.0 ATM BRCA1 BRCA2 CHEK2 ERBB2 ESR1
12 hereditary site-specific ovarian cancer syndrome 10.8 BRCA1 BRCA2
13 breast reconstruction 10.7 BRCA1 BRCA2
14 breast-ovarian cancer, familial 1 10.7 BRCA1 BRCA2
15 peritoneum cancer 10.7 BRCA1 BRCA2
16 premature menopause 10.6 BRCA1 BRCA2
17 clear cell adenofibroma 10.6 BRCA1 BRCA2
18 cystadenofibroma 10.6 BRCA1 BRCA2
19 lynch syndrome i 10.5 BRCA1 BRCA2
20 fanconi anemia, complementation group d2 10.5 BRCA2 RAD51
21 myxosarcoma 10.5 ATM BRCA1
22 mutagen sensitivity 10.4 BRCA1 BRCA2
23 breast giant fibroadenoma 10.4 BRCA2 ESR1
24 nijmegen breakage syndrome 10.2 ATM BRCA1 CHEK2
25 t-cell prolymphocytic leukemia 10.2 ATM CHEK2
26 congenital hypoplastic anemia 10.2 BRCA2 RAD51
27 comedo carcinoma 10.1 ERBB2 ESR1
28 tuberculous salpingitis 10.0 BRCA1 BRCA2 ERBB2
29 uterine corpus serous adenocarcinoma 10.0 BRCA1 BRCA2 ERBB2
30 fallopian tube adenocarcinoma 10.0 BRCA1 BRCA2 ERBB2
31 ovarian cancer 1 10.0 BRCA1 BRCA2 ERBB2
32 aging 10.0
33 corneal abscess 9.9 PGR RAD51
34 hidradenocarcinoma 9.9 ERBB2 ESR1
35 vulvar syringoma 9.9 ESR1 PGR
36 lung leiomyoma 9.9 ESR1 PGR
37 vestibular gland benign neoplasm 9.9 ESR1 PGR
38 bartholin's gland adenoma 9.9 ESR1 PGR
39 vulvar benign neoplasm 9.9 ESR1 PGR
40 trigonitis 9.9 ESR1 PGR
41 vulvar leiomyoma 9.9 ESR1 PGR
42 predominantly cortical thymoma 9.9 ESR1 PGR
43 progesterone resistance 9.9 ESR1 PGR
44 cribriform carcinoma 9.9 ESR1 PGR
45 endometrial squamous cell carcinoma 9.9 ESR1 PGR
46 gastric signet ring cell adenocarcinoma 9.9 ESR1 PGR
47 endometrial mucinous adenocarcinoma 9.9 ESR1 PGR
48 adenoid basal cell carcinoma 9.9 ESR1 PGR
49 gender identity disorder 9.9 ESR1 PGR
50 bartholin's gland benign neoplasm 9.9 ESR1 PGR

Graphical network of the top 20 diseases related to Bilateral Breast Cancer:



Diseases related to Bilateral Breast Cancer

Symptoms & Phenotypes for Bilateral Breast Cancer

GenomeRNAi Phenotypes related to Bilateral Breast Cancer according to GeneCards Suite gene sharing:

26 (show all 19)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased homologous recombination repair frequency GR00151-A-1 10.59 RAD51 BRCA1
2 Decreased homologous recombination repair frequency GR00151-A-2 10.59 RAD51 BRCA1
3 Decreased homologous recombination repair frequency GR00236-A-1 10.59 RAD51 PGR BRCA1 BRCA2
4 Decreased homologous recombination repair frequency GR00236-A-2 10.59 RAD51 PGR BRCA1 ATM BRCA2
5 Decreased homologous recombination repair frequency GR00236-A-3 10.59 RAD51 BRCA1 BRCA2
6 Decreased viability GR00221-A-1 10.58 ESR1
7 Decreased viability GR00221-A-2 10.58 ESR1 CHEK2 BRCA1
8 Decreased viability GR00221-A-3 10.58 ERBB2 CHEK2 BRCA1 ATM
9 Decreased viability GR00221-A-4 10.58 ERBB2 ESR1 CHEK2 ATM
10 Decreased viability GR00301-A 10.58 BRCA1
11 Decreased viability GR00342-S-2 10.58 CHEK2
12 Decreased viability GR00402-S-2 10.58 ERBB2 ESR1 CHEK2 BRCA1 ATM
13 Decreased viability in esophageal squamous lineage GR00235-A 9.87 CHEK2 ERBB2 ESR1 PGR RAD51 BRCA1
14 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.55 RAD51 BRCA1 ATM BRCA2 CHEK2
15 Decreased viability after ionizing radiation GR00232-A-2 9.54 BRCA1 ATM BRCA2
16 Decreased viability with cisplatin GR00101-A-4 9.43 RAD51 BRCA2 BRCA1
17 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.28 CHEK2 BRCA1 ATM BRCA2
18 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.28 RAD51 CHEK2 BRCA1 ATM BRCA2
19 Synthetic lethal with cisplatin GR00101-A-1 9.13 RAD51 BRCA2 BRCA1

MGI Mouse Phenotypes related to Bilateral Breast Cancer:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.11 RAD51 ESR1 PGR BRCA2 ATM CHEK2
2 embryo MP:0005380 10.02 PGR RAD51 BRCA2 ESR1 ATM BRCA1
3 homeostasis/metabolism MP:0005376 10.01 ESR1 FHIT PGR ERBB2 BRCA2 ATM
4 endocrine/exocrine gland MP:0005379 10 PGR BRCA2 ESR1 ATM CHEK2 BRCA1
5 hematopoietic system MP:0005397 9.98 ESR1 FHIT PGR BRCA1 BRCA2 ATM
6 immune system MP:0005387 9.91 ESR1 FHIT PGR BRCA1 BRCA2 ATM
7 digestive/alimentary MP:0005381 9.89 ESR1 FHIT BRCA1 ERBB2 BRCA2
8 integument MP:0010771 9.87 FHIT PGR BRCA2 ESR1 ATM BRCA1
9 mortality/aging MP:0010768 9.81 FHIT PGR RAD51 BRCA2 ESR1 ATM
10 limbs/digits/tail MP:0005371 9.65 ESR1 PGR ERBB2 BRCA2 BRCA1
11 neoplasm MP:0002006 9.56 FHIT PGR BRCA2 ESR1 ATM CHEK2
12 reproductive system MP:0005389 9.1 ESR1 PGR BRCA1 ERBB2 BRCA2 ATM

Drugs & Therapeutics for Bilateral Breast Cancer

Drugs for Bilateral Breast Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Anastrozole Approved, Investigational Phase 3 120511-73-1 2187
2
Exemestane Approved, Investigational Phase 3 107868-30-4 60198
3
Tamoxifen Approved Phase 3 10540-29-1 2733526
4
Letrozole Approved, Investigational Phase 3 112809-51-5 3902
5
Citric Acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
6 Chelating Agents Phase 3
7 Selective Estrogen Receptor Modulators Phase 3
8 Steroid Synthesis Inhibitors Phase 3
9 Hormone Antagonists Phase 3
10 Hormones Phase 3
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
12 Estrogen Antagonists Phase 3
13 Estrogen Receptor Modulators Phase 3
14 Estrogens Phase 3
15 Anticoagulants Phase 3
16 Aromatase Inhibitors Phase 3
17 Bone Density Conservation Agents Phase 3
18 Calcium, Dietary Phase 3
19 Antineoplastic Agents, Hormonal Phase 3
20 Citrate Nutraceutical Phase 3
21
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
22
leucovorin Approved, Nutraceutical Phase 2 58-05-9 143 6006
23
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
24 Alkylating Agents Phase 2
25 Micronutrients Phase 2
26 Hematinics Phase 2
27 Trace Elements Phase 2
28 Vaccines Phase 2
29 Vitamin B Complex Phase 2
30 Vitamins Phase 2
31 Immunosuppressive Agents Phase 2
32 Antirheumatic Agents Phase 2
33 Antineoplastic Agents, Alkylating Phase 2
34 Folate Nutraceutical Phase 2
35 Vitamin B9 Nutraceutical Phase 2
36
Acetaminophen Approved Not Applicable 103-90-2 1983
37 Analgesics Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Tamoxifen Citrate, Letrozole, Anastrozole, or Exemestane With or Without Chemotherapy in Treating Patients With Invasive RxPONDER Breast Cancer Active, not recruiting NCT01272037 Phase 3 Anastrozole;Exemestane;Letrozole;Systemic Chemotherapy;Tamoxifen Citrate
2 Multi-epitope Folate Receptor Alpha Peptide Vaccine, Sargramostim, and Cyclophosphamide in Treating Patients With Triple Negative Breast Cancer Recruiting NCT03012100 Phase 2 Cyclophosphamide
3 Pre-operative Magnetic Resonance Imaging (MRI) in Young Breast Cancer Patients Unknown status NCT00801476 Not Applicable
4 EMG at Performing ULTN 1 in Breast Cancer Patients Completed NCT02599467 Not Applicable
5 Study of Radiation Exposure and Bilateral Breast Cancer Active, not recruiting NCT00903591
6 Genetic Counseling for Breast Cancer Survivors (GC for BC) Active, not recruiting NCT02451735 Not Applicable

Search NIH Clinical Center for Bilateral Breast Cancer

Genetic Tests for Bilateral Breast Cancer

Genetic tests related to Bilateral Breast Cancer:

# Genetic test Affiliating Genes
1 Bilateral Breast Carcinoma 29

Anatomical Context for Bilateral Breast Cancer

MalaCards organs/tissues related to Bilateral Breast Cancer:

41
Breast, Bone, Prostate, Lung, Testes, Pituitary, Cervix

Publications for Bilateral Breast Cancer

Articles related to Bilateral Breast Cancer:

(show top 50) (show all 224)
# Title Authors Year
1
Sequential Sentinel Node Scintigraphy With Planar and SPECT/CT Images Revealed Contralateral Drainage From Ipsilateral Breast Tumor Relapse in a Patient With Bilateral Breast Cancer. ( 29659396 )
2018
2
Including internal mammary lymph nodes in radiation therapy for synchronous bilateral breast cancer: an international survey of treatment technique and clinical priorities. ( 29869775 )
2018
3
Delayed Recurrent and Bilateral Breast Cancer in Patients With Partial Poland's Anomaly: Report of 2 Rare Cases and Review of the Literature. ( 29475749 )
2018
4
Dissecting Time- from Tumor-Related Gene Expression Variability in Bilateral Breast Cancer. ( 29315233 )
2018
5
First clinical report of helical tomotherapy with simultaneous integrated boost for synchronous bilateral breast cancer. ( 28707988 )
2017
6
A novel germline TP53 mutation p.Pro190Arg detected in a patient with lung and bilateral breast cancers. ( 28499267 )
2017
7
Synchronous Bilateral Breast Cancer in a Patient With Nager Syndrome. ( 28139434 )
2017
8
Bilateral Breast Cancer After Multimodality Treatment: A Report of Clinical Outcomes in an Asian Population. ( 29254601 )
2017
9
Bilateral Breast Cancer After Prophylactic Bilateral Pulmonary Irradiation. ( 28272005 )
2017
10
Gastric metastasis of bilateral breast cancer. ( 28280631 )
2017
11
pCR rates in patients with bilateral breast cancer after neoadjuvant anthracycline-taxane based-chemotherapy - A retrospective pooled analysis of individual patients data of four German neoadjuvant trials. ( 28063331 )
2017
12
Synchronous Bilateral Breast Cancer With Discordant Histology. ( 28412779 )
2017
13
Treatment of bilateral breast cancer and regional nodes using an opposed lateral beam arrangement. ( 28867548 )
2017
14
Synchronous bilateral breast cancer irradiation: clinical and dosimetrical issues using volumetric modulated arc therapy and simultaneous integrated boost. ( 28224401 )
2017
15
Bilateral breast keloids in an elderly woman associated with bilateral breast cancers and high concentration of serum tumor growth factor-I^. ( 29098727 )
2017
16
Bilateral Breast Cancer with Neurofibromatosis Type 1 Patient: Case Report. ( 29082380 )
2017
17
PALB2 mutation in a woman with bilateral breast cancer: A case report. ( 28413668 )
2017
18
Femoral Placement of Totally Implantable Venous Access Ports in Patients with Bilateral Breast Cancer. ( 26855441 )
2016
19
Bilateral breast cancer resection performed under the bilateral transversus thoracic muscle plane block. ( 27555202 )
2016
20
Image-guided intensity-modulated radiotherapy for refractory bilateral breast cancer in a patient with extensive cutaneous metastasis in the chest and abdominal walls. ( 27284253 )
2016
21
Unilateral Arm Urticaria Presenting as a Paraneoplastic Manifestation of Metachronous Bilateral Breast Cancer. ( 26933416 )
2016
22
BILATERAL BREAST CANCER: DIAGNOSIS AND PROGNOSIS. ( 27483711 )
2016
23
Helical tomotherapy for bilateral breast cancer: Clinical experience. ( 27253152 )
2016
24
Challenges of treating incidental synchronous bilateral breast cancer with differing tumour biology. ( 27539136 )
2016
25
Co-existence of a giant cell tumour of the tendon sheath and schwannoma in a patient with bilateral breast cancer: A potential cause of false positive findings in (18)F-FDG PET/CT studies. ( 27329560 )
2016
26
Disease evolution and heterogeneity in bilateral breast cancer. ( 27904775 )
2016
27
Metabolic flare phenomenon on 18 fluoride-fluorodeoxy glucose positron emission tomography-computed tomography scans in a patient with bilateral breast cancer treated with second-line chemotherapy and bevacizumab. ( 25829734 )
2015
28
Bilateral breast cancer, synchronous and metachronous; differences and outcome. ( 26268697 )
2015
29
A case of synchronous multiple bilateral breast cancer after breast augmentation. ( 26722625 )
2015
30
Long-term effects of first degree family history of breast cancer in young women: Recurrences and bilateral breast cancer. ( 26399280 )
2015
31
Coexistence of systemic lupus erythematosus, Hashimoto's thyroiditis, and bilateral breast cancer in the same patient: a random association? ( 26399842 )
2015
32
Impact of bilateral breast cancer on prognosis: synchronous versus metachronous tumors. ( 25735321 )
2015
33
Bilateral breast cancer following augmentation mammaplasty with polyacrylamide hydrogel injection: A case report. ( 26137129 )
2015
34
Surgical management for early-stage bilateral breast cancer patients in china. ( 25874699 )
2015
35
Breast-Conserving Surgery in Bilateral Breast Cancer. ( 26265365 )
2015
36
Use of tomotherapy in treatment of synchronous bilateral breast cancer: dosimetric comparison study. ( 25605345 )
2015
37
Multifocal Bilateral Breast Cancer and Breast Follicular Lymphoma: A Simple Coincidence? ( 26472982 )
2015
38
Bilateral breast cancer with a unilateral carcinoma within a fibroadenoma: A case report. ( 26622700 )
2015
39
Primary Squamous Cell Carcinoma of the Breast After Cured Bilateral Breast Cancer. ( 25398815 )
2014
40
Primary synchronous bilateral breast cancer. ( 25494117 )
2014
41
Morphoimmunohistochemical characteristics of synchronous bilateral breast cancer. ( 25257431 )
2014
42
Prostate cancer in a man with a BRCA2 mutation and a personal history of bilateral breast cancer. ( 25112434 )
2014
43
A clinicopathological study of early-stage synchronous bilateral breast cancer: a retrospective evaluation and prospective validation of potential risk factors. ( 24736632 )
2014
44
A novel deleterious PTEN mutation in a patient with early-onset bilateral breast cancer. ( 24498881 )
2014
45
Prognosis of synchronous bilateral breast cancer: a review and meta-analysis of observational studies. ( 25007962 )
2014
46
Periductal stromal tumor of the breast with synchronous bilateral breast cancer. ( 24982380 )
2014
47
A rare recurrence of bilateral breast cancer in the esophagus coincidentally associated with primary gastric cancer: a case report. ( 24533645 )
2014
48
A case of synchronous bilateral breast cancer with different pathological responses to neoadjuvant chemotherapy with different biological character. ( 23875131 )
2013
49
Synchronous bilateral breast cancer in a male. ( 24319497 )
2013
50
The molecular and clinicopathologic characteristics of bilateral breast cancer. ( 24005135 )
2013

Variations for Bilateral Breast Cancer

Expression for Bilateral Breast Cancer

Search GEO for disease gene expression data for Bilateral Breast Cancer.

Pathways for Bilateral Breast Cancer

Pathways related to Bilateral Breast Cancer according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.57 ATM BRCA1 CHEK2 ERBB2 ESR1 PGR
2
Show member pathways
13.2 ATM BRCA1 BRCA2 CHEK2 RAD51
3
Show member pathways
13.01 ATM BRCA1 BRCA2 CHEK2 RAD51
4
Show member pathways
12.74 ATM BRCA1 BRCA2 CHEK2 RAD51
5 12.64 BRCA2 ERBB2 ESR1 RAD51
6
Show member pathways
12.54 BRCA1 BRCA2 ERBB2 ESR1 PGR
7
Show member pathways
12.4 ATM BRCA1 BRCA2 ERBB2 ESR1 FHIT
8
Show member pathways
12.35 ATM BRCA1 BRCA2 RAD51
9 12.27 ATM BRCA1 BRCA2 CHEK2 RAD51
10
Show member pathways
12.25 ATM CHEK2 ERBB2
11
Show member pathways
12.24 ATM BRCA1 BRCA2 CHEK2 ESR1 RAD51
12
Show member pathways
12.23 ATM BRCA1 CHEK2 RAD51
13
Show member pathways
12.18 ATM BRCA1 CHEK2
14
Show member pathways
12.14 ATM BRCA1 BRCA2 RAD51
15
Show member pathways
12.08 ATM BRCA1 CHEK2
16
Show member pathways
12.06 BRCA1 CHEK2 ESR1 PGR
17
Show member pathways
11.94 ATM BRCA1 BRCA2 RAD51
18
Show member pathways
11.81 ERBB2 ESR1 PGR
19 11.74 BRCA1 BRCA2 RAD51
20 11.62 ATM BRCA1 ERBB2
21
Show member pathways
11.61 ATM BRCA1 CHEK2 RAD51
22 11.44 ATM BRCA1 CHEK2 ERBB2
23 11.39 ATM BRCA1 CHEK2
24 11.34 ATM BRCA1 CHEK2
25 11.33 ATM CHEK2
26
Show member pathways
11.32 BRCA1 ESR1
27
Show member pathways
11.31 ATM CHEK2
28 11.29 ATM BRCA1 BRCA2 CHEK2 ESR1 RAD51
29
Show member pathways
11.27 ATM BRCA1 BRCA2 CHEK2 RAD51
30 11.24 BRCA2 CHEK2 ESR1
31 11.14 ATM BRCA1
32 11.14 ATM PGR
33 11.07 ATM BRCA1 RAD51
34 10.98 ATM CHEK2
35 10.89 ATM BRCA1

GO Terms for Bilateral Breast Cancer

Cellular components related to Bilateral Breast Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.8 ATM BRCA1 BRCA2 CHEK2 ESR1 PGR
2 protein-containing complex GO:0032991 9.62 BRCA1 BRCA2 ESR1 RAD51
3 nucleus GO:0005634 9.61 ATM BRCA1 BRCA2 CHEK2 ERBB2 ESR1
4 condensed nuclear chromosome GO:0000794 9.4 BRCA1 RAD51
5 condensed chromosome GO:0000793 9.37 BRCA1 RAD51
6 nuclear chromosome, telomeric region GO:0000784 9.33 ATM BRCA2 RAD51
7 lateral element GO:0000800 8.8 BRCA1 BRCA2 RAD51

Biological processes related to Bilateral Breast Cancer according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.95 ATM BRCA1 CHEK2 FHIT
2 cell cycle GO:0007049 9.93 ATM BRCA1 BRCA2 CHEK2
3 positive regulation of transcription, DNA-templated GO:0045893 9.91 BRCA1 BRCA2 CHEK2 ESR1
4 cellular response to DNA damage stimulus GO:0006974 9.83 ATM BRCA1 BRCA2 CHEK2 RAD51
5 regulation of apoptotic process GO:0042981 9.81 ATM BRCA1 CHEK2 ESR1
6 protein autophosphorylation GO:0046777 9.77 ATM CHEK2 ERBB2
7 DNA repair GO:0006281 9.77 ATM BRCA1 BRCA2 CHEK2 RAD51
8 regulation of signal transduction by p53 class mediator GO:1901796 9.76 ATM BRCA1 CHEK2
9 DNA recombination GO:0006310 9.73 BRCA1 BRCA2 RAD51
10 double-strand break repair GO:0006302 9.67 BRCA1 BRCA2 CHEK2
11 negative regulation of G0 to G1 transition GO:0070317 9.65 BRCA1 RAD51
12 reciprocal meiotic recombination GO:0007131 9.64 ATM RAD51
13 response to gamma radiation GO:0010332 9.63 BRCA2 CHEK2
14 response to ionizing radiation GO:0010212 9.63 ATM BRCA1 RAD51
15 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.62 BRCA2 CHEK2
16 cellular response to gamma radiation GO:0071480 9.62 ATM CHEK2
17 female gonad development GO:0008585 9.61 ATM BRCA2
18 DNA double-strand break processing GO:0000729 9.59 ATM BRCA1
19 replicative senescence GO:0090399 9.58 ATM CHEK2
20 telomere maintenance via recombination GO:0000722 9.57 BRCA2 RAD51
21 double-strand break repair via homologous recombination GO:0000724 9.56 ATM BRCA1 BRCA2 RAD51
22 chromosome organization involved in meiotic cell cycle GO:0070192 9.55 ATM RAD51
23 DNA damage induced protein phosphorylation GO:0006975 9.52 ATM CHEK2
24 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.5 BRCA1 BRCA2 CHEK2
25 chordate embryonic development GO:0043009 9.48 BRCA1 BRCA2
26 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.46 ATM BRCA1 BRCA2 CHEK2
27 mitotic recombination-dependent replication fork processing GO:1990426 9.4 BRCA2 RAD51
28 DNA synthesis involved in DNA repair GO:0000731 9.26 ATM BRCA1 BRCA2 RAD51
29 strand displacement GO:0000732 8.92 ATM BRCA1 BRCA2 RAD51
30 transcription, DNA-templated GO:0006351 10.11 BRCA1 CHEK2 ERBB2 ESR1 FHIT PGR
31 regulation of transcription, DNA-templated GO:0006355 10.08 BRCA1 BRCA2 CHEK2 ERBB2 ESR1 FHIT

Molecular functions related to Bilateral Breast Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.73 ATM BRCA1 BRCA2 ESR1 PGR RAD51
2 nuclear receptor activity GO:0004879 9.37 ESR1 PGR
3 nucleotide binding GO:0000166 9.35 ATM CHEK2 ERBB2 FHIT RAD51
4 protein C-terminus binding GO:0008022 9.33 BRCA2 ERBB2 RAD51
5 steroid binding GO:0005496 9.32 ESR1 PGR
6 identical protein binding GO:0042802 9.17 BRCA2 CHEK2 ERBB2 ESR1 FHIT PGR

Sources for Bilateral Breast Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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