MCID: BLT009
MIFTS: 11

Bilateral Generalized Polymicrogyria

Categories: Fetal diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Bilateral Generalized Polymicrogyria

MalaCards integrated aliases for Bilateral Generalized Polymicrogyria:

Name: Bilateral Generalized Polymicrogyria 54 60
Bilateral Generalised Polymicrogyria 54

Characteristics:

Orphanet epidemiological data:

60
bilateral generalized polymicrogyria
Inheritance: Autosomal recessive;

Classifications:



External Ids:

ICD10 via Orphanet 35 Q04.3
Orphanet 60 ORPHA208447

Summaries for Bilateral Generalized Polymicrogyria

NIH Rare Diseases : 54 Bilateral generalized polymicrogyria is a rare neurological disorder that affects the cerebral cortex (the outer surface of the brain). This is the most widespread form of polymicrogyria and typically affects the entire surface of the brain. Signs and symptoms include severe intellectual disability, problems with movement, and seizures that are difficult or impossible to treat. While the exact cause of bilateral generalized polymicrogyria is not fully understood, it is thought to be due to improper brain development during embryonic growth. Most cases appear to follow an autosomal recessive pattern of inheritance. Treatment is based on the signs and symptoms present in each person.

MalaCards based summary : Bilateral Generalized Polymicrogyria, also known as bilateral generalised polymicrogyria, is related to polymicrogyria. An important gene associated with Bilateral Generalized Polymicrogyria is GRIN1 (Glutamate Ionotropic Receptor NMDA Type Subunit 1). Affiliated tissues include brain and cortex.

Related Diseases for Bilateral Generalized Polymicrogyria

Diseases related to Bilateral Generalized Polymicrogyria via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 polymicrogyria 9.9

Symptoms & Phenotypes for Bilateral Generalized Polymicrogyria

Drugs & Therapeutics for Bilateral Generalized Polymicrogyria

Search Clinical Trials , NIH Clinical Center for Bilateral Generalized Polymicrogyria

Genetic Tests for Bilateral Generalized Polymicrogyria

Anatomical Context for Bilateral Generalized Polymicrogyria

MalaCards organs/tissues related to Bilateral Generalized Polymicrogyria:

42
Brain, Cortex

Publications for Bilateral Generalized Polymicrogyria

Articles related to Bilateral Generalized Polymicrogyria:

# Title Authors Year
1
Bilateral generalized polymicrogyria (BGP): a distinct syndrome of cortical malformation. ( 15159468 )
2004

Variations for Bilateral Generalized Polymicrogyria

Expression for Bilateral Generalized Polymicrogyria

Search GEO for disease gene expression data for Bilateral Generalized Polymicrogyria.

Pathways for Bilateral Generalized Polymicrogyria

GO Terms for Bilateral Generalized Polymicrogyria

Sources for Bilateral Generalized Polymicrogyria

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....