MCID: BLD033
MIFTS: 35

Bile Duct Adenoma

Categories: Cancer diseases, Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Bile Duct Adenoma

MalaCards integrated aliases for Bile Duct Adenoma:

Name: Bile Duct Adenoma 12 15 17
Adenoma, Bile Duct 45
Adenoma Bile Duct 56
Cholangioadenoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5381
MeSH 45 D002759
NCIt 51 C2942
SNOMED-CT 69 39471001
UMLS 74 C0008309

Summaries for Bile Duct Adenoma

Disease Ontology : 12 A biliary tract benign neoplasm that results in a small firm white nodule with multiple bile ducts that are located in a fibrous stroma.

MalaCards based summary : Bile Duct Adenoma, also known as adenoma, bile duct, is related to intrahepatic cholangiocarcinoma and cavernous hemangioma. An important gene associated with Bile Duct Adenoma is KRT7 (Keratin 7), and among its related pathways/superpathways are MicroRNAs in cancer and Cytoskeletal Signaling. The drug Cola has been mentioned in the context of this disorder. Affiliated tissues include liver, lung and colon.

Related Diseases for Bile Duct Adenoma

Diseases related to Bile Duct Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 229)
# Related Disease Score Top Affiliating Genes
1 intrahepatic cholangiocarcinoma 29.6 KRT20 KRT7 MUC1
2 cavernous hemangioma 29.6 KRT7 MUC1 VIM
3 cholangiocarcinoma 29.6 CDKN2A KRT20 KRT7 MUC1
4 cholangiolocellular carcinoma 29.4 CDKN2A EZH2 MUC1
5 renal cell carcinoma, nonpapillary 29.2 KRT20 KRT7 MUC1 VIM
6 intrahepatic bile duct adenoma 12.6
7 extrahepatic bile duct adenoma 12.4
8 extrahepatic bile duct papillary adenoma 11.3
9 adenoma 10.8
10 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.3
11 colorectal adenocarcinoma 10.3 KRT20 KRT7
12 large cell neuroendocrine carcinoma 10.3 KRT20 KRT7
13 small intestine cancer 10.3 KRT20 KRT7
14 sweat gland cancer 10.3 KRT20 KRT7
15 ovarian brenner tumor 10.3 KRT20 KRT7
16 cecum adenocarcinoma 10.3 KRT20 KRT7
17 clear cell adenocarcinoma 10.3 KRT20 KRT7
18 bronchiolo-alveolar adenocarcinoma 10.3 KRT20 KRT7
19 cystitis cystica 10.3 KRT20 KRT7
20 intestinal obstruction 10.3 KRT20 KRT7
21 horseshoe kidney 10.3 KRT20 KRT7
22 cystic basal cell carcinoma 10.3 KRT20 KRT7
23 seminal vesicle adenocarcinoma 10.2 KRT20 KRT7
24 transverse colon cancer 10.2 KRT20 KRT7
25 appendix adenocarcinoma 10.2 KRT20 KRT7
26 malignant syringoma 10.2 KRT20 KRT7
27 glandular cystitis 10.2 KRT20 KRT7
28 papillary transitional carcinoma 10.2 KRT20 KRT7
29 fibrolamellar carcinoma 10.2 KRT7 VIM
30 eyelid carcinoma 10.2 KRT20 KRT7
31 krukenberg carcinoma 10.2 KRT20 KRT7
32 large intestine adenocarcinoma 10.2 KRT20 KRT7
33 granulosa cell tumor of the ovary 10.2 KRT7 VIM
34 linitis plastica 10.2 KRT20 KRT7
35 hidradenocarcinoma 10.2 KRT7 VIM
36 lung acinar adenocarcinoma 10.2 KRT20 KRT7
37 small cell carcinoma of the bladder 10.2 KRT20 KRT7
38 intratubular embryonal carcinoma 10.2 KRT20 KRT7
39 hepatitis 10.2
40 jejunal adenocarcinoma 10.2 KRT20 KRT7
41 ovarian mucinous adenocarcinoma 10.2 KRT20 KRT7
42 thymus adenocarcinoma 10.2 KRT20 KRT7
43 appendix disease 10.2 KRT20 KRT7
44 gastric diffuse adenocarcinoma 10.2 KRT20 KRT7
45 meibomian cyst 10.2 KRT20 KRT7
46 bladder lymphoma 10.2 KRT20 KRT7
47 papillary serous adenocarcinoma 10.2 KRT20 KRT7
48 bladder adenocarcinoma 10.2 KRT20 KRT7
49 chronic cystitis 10.2 KRT20 KRT7
50 papillary adenoma 10.2 KRT7 VIM

Graphical network of the top 20 diseases related to Bile Duct Adenoma:



Diseases related to Bile Duct Adenoma

Symptoms & Phenotypes for Bile Duct Adenoma

Drugs & Therapeutics for Bile Duct Adenoma

Drugs for Bile Duct Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Cola Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Effects of An Addition of Water Enema to PEG for Colon Preparation Completed NCT03270046 Not Applicable
2 Destruction of Residual Endo-biliary Dysplastic Buds After Endoscopic Ampullectomy Completed NCT02825524 Not Applicable
3 Volumetric Laser Endomicroscopy's (VLE) Diagnostic Accuracy Validation Study: Impact on Clinical Management Study Enrolling by invitation NCT03951324

Search NIH Clinical Center for Bile Duct Adenoma

Cochrane evidence based reviews: adenoma, bile duct

Genetic Tests for Bile Duct Adenoma

Anatomical Context for Bile Duct Adenoma

MalaCards organs/tissues related to Bile Duct Adenoma:

42
Liver, Lung, Colon, Thymus, Appendix, Kidney, Ovary

The Foundational Model of Anatomy Ontology organs/tissues related to Bile Duct Adenoma:

20
A Fibrous Stroma

Publications for Bile Duct Adenoma

Articles related to Bile Duct Adenoma:

(show all 48)
# Title Authors Year
1
Single-operator cholangioscopy for diagnosis of cholangioadenoma (bile duct adenoma) and its potential impact on surgical management. ( 30410950 )
2018
2
Imaging features of bile duct adenoma: case series and review of literature. ( 30211677 )
2018
3
A Rare Case of Incidental Common Bile Duct Adenoma-Endoscopic Ultrasound Evaluation ( 29588259 )
2018
4
Bile duct adenoma in patient with chronic hepatitis C: As a benign neoplasm by pathological and imaging studies. ( 27663997 )
2016
5
Resolution of Bile Duct Adenoma over Follow-up Period; A Case Report. ( 27957298 )
2016
6
Intrahepatic bile duct adenoma in a patient with chronic hepatitis B accompanied by elevation of alpha-fetoprotein. ( 26770929 )
2015
7
Intrahepatic bile duct adenoma (peribiliary gland hamartoma): a case report and review of literature. ( 26191317 )
2015
8
Magnetic Resonance Imaging Findings of Intrahepatic Bile Duct Adenoma: A Report of 4 Cases. ( 26248149 )
2015
9
Intrahepatic Cholangiocarcinoma with Ductal Plate Malformation-like Feature Associated with Bile Duct Adenoma. ( 26265688 )
2015
10
Bile duct adenoma should not be designated as a reactive process. ( 25727261 )
2015
11
Bile duct adenoma (hamartoma of peribiliary glands): Importance of an adequate diagnosis. ( 24125022 )
2015
12
Bile duct adenoma and von Meyenburg complex-like duct arising in hepatitis and cirrhosis: pathogenesis and histological characteristics. ( 25329860 )
2014
13
Cytopathologic, histopathologic, and immunohistochemical features of intrahepatic clear cell bile duct adenoma: a case report and review of the literature. ( 24955270 )
2014
14
Bile duct adenoma: a case report and literature review. ( 24767257 )
2014
15
RE: Diffusion-weighted MRI in intrahepatic bile duct adenoma arising from the cirrhotic liver. ( 24843248 )
2014
16
Immunostaining for polycomb group protein EZH2 and senescent marker p16INK4a may be useful to differentiate cholangiolocellular carcinoma from ductular reaction and bile duct adenoma. ( 24487593 )
2014
17
Bile duct adenoma with oncocytic features. ( 24592348 )
2014
18
Intrahepatic bile duct adenoma with oncocytic features. ( 22891770 )
2013
19
Intrahepatic bile duct adenoma mimicking hepatic metastasis: case report and review of the literature. ( 23666160 )
2013
20
Diffusion-weighted MRI in intrahepatic bile duct adenoma arising from the cirrhotic liver. ( 24043970 )
2013
21
Ultrasonography of intrahepatic bile duct adenoma with renal cell carcinoma: correlation with pathology. ( 27277244 )
2013
22
Incidental removal of distal common bile duct adenoma after plastic stent placement. ( 22396252 )
2012
23
A case of very large intrahepatic bile duct adenoma followed for 7 years. ( 22574289 )
2012
24
Bile duct adenoma causing recurrent cholangitis: diagnosis and management with targeted Spyglass access and radiofrequency ablation. ( 22933260 )
2012
25
A combination of snare polypectomy and apc therapy for prolapsing common bile duct adenoma. ( 23687608 )
2012
26
An immunohistochemical profile of the so-called bile duct adenoma: clues to pathogenesis. ( 20679879 )
2010
27
Imaging findings of intrahepatic bile duct adenoma (peribiliary gland hamartoma): a case report and literature review. ( 20808701 )
2010
28
Common bile duct adenoma: case report and brief review of literature. ( 21150400 )
2010
29
[Cholangiocarcinoma with bile duct adenoma and hamartoma-like lesion in the bile duct]. ( 20203450 )
2010
30
Alpha-1-antitrypsin-positive "signet-ring" bile duct adenoma in a patient with M(MALTON) mutation. ( 18417685 )
2008
31
Bile duct adenoma with oncocytic features. ( 16918984 )
2006
32
Pancreatitis complicating mucin-hypersecreting common bile duct adenoma. ( 16937485 )
2006
33
Magnetic resonance findings of bile duct adenoma with calcification. ( 16958429 )
2006
34
Acute cholangitis secondary to a common bile duct adenoma. ( 12845956 )
2003
35
Extra-hepatic bile duct adenoma in a patient with a choledochal cyst. ( 12603542 )
2003
36
Bile duct adenoma: management by subtotal excision. ( 14603832 )
2003
37
Mucin-secreting bile duct adenoma--clinicopathological resemblance to intraductal papillary mucinous tumor of the pancreas. ( 12207078 )
2002
38
Atypical bile duct adenoma, clear cell type: a previously undescribed tumor of the liver. ( 11420469 )
2001
39
[Concomitant occurrence of angiomyolipoma, focal nodular hyperplasia, bile duct adenoma, and cavernous hemangioma in the liver]. ( 11766641 )
2001
40
Radiologic features of intrahepatic bile duct adenoma: a look at the surface of the liver. ( 10524847 )
1999
41
The so-called bile duct adenoma is a peribiliary gland hamartoma. ( 8669534 )
1996
42
Cholangiocarcinoma arising in bile duct adenoma with focal area of bile duct hamartoma. ( 7757293 )
1995
43
Incarcerated bile duct adenoma as a rare cause of acute cholestatic pancreatitis. ( 8608764 )
1995
44
Bile duct adenoma. A study of 152 cases. ( 3046396 )
1988
45
Bile duct adenoma. ( 2990370 )
1985
46
The bile duct adenoma. A lesion distinct from Meyenburg complex. ( 6548370 )
1984
47
Surgical importance of bile duct adenoma of liver. ( 13545501 )
1958
48
Multiple bile duct adenoma. ( 20986272 )
1946

Variations for Bile Duct Adenoma

Cosmic variations for Bile Duct Adenoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM521 KRAS biliary tract,bile duct,other,adenoma c.35G>A p.G12D 12:25245350-25245350 0
2 COSM520 KRAS biliary tract,bile duct,other,adenoma c.35G>T p.G12V 12:25245350-25245350 0

Expression for Bile Duct Adenoma

Search GEO for disease gene expression data for Bile Duct Adenoma.

Pathways for Bile Duct Adenoma

Pathways related to Bile Duct Adenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.61 CDKN2A EZH2 VIM
2 11.41 KRT20 KRT7 MUC1 VIM
3 11.05 EZH2 VIM

GO Terms for Bile Duct Adenoma

Cellular components related to Bile Duct Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 8.8 KRT20 KRT7 VIM

Biological processes related to Bile Duct Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament organization GO:0045109 8.62 KRT20 VIM

Sources for Bile Duct Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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