MCID: BLD033
MIFTS: 34

Bile Duct Adenoma

Categories: Cancer diseases, Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Bile Duct Adenoma

MalaCards integrated aliases for Bile Duct Adenoma:

Name: Bile Duct Adenoma 12 15 17
Adenoma, Bile Duct 44
Adenoma Bile Duct 54
Cholangioadenoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5381
MeSH 44 D002759
NCIt 50 C2942
SNOMED-CT 67 39471001
UMLS 70 C0008309

Summaries for Bile Duct Adenoma

Disease Ontology : 12 A biliary tract benign neoplasm that results in a small firm white nodule with multiple bile ducts that are located in a fibrous stroma.

MalaCards based summary : Bile Duct Adenoma, also known as adenoma, bile duct, is related to intrahepatic bile duct adenoma and adenoma. An important gene associated with Bile Duct Adenoma is KRT7 (Keratin 7), and among its related pathways/superpathways are MicroRNAs in cancer and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drug Cola has been mentioned in the context of this disorder. Affiliated tissues include a fibrous stroma, colon and liver.

Related Diseases for Bile Duct Adenoma

Diseases related to Bile Duct Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 449)
# Related Disease Score Top Affiliating Genes
1 intrahepatic bile duct adenoma 31.2 TP53 NCAM1 KRT7 KRT20 KRT19
2 adenoma 30.7 TP53 MUC1 KRT7 KRT20 CDKN2A
3 bile duct cysts 30.2 KRT7 KRT19
4 villous adenoma 30.1 TP53 MUC1 KRT7 KRT20
5 cholecystitis 30.1 TP53 MUC1 CDKN2A
6 intrahepatic cholangiocarcinoma 30.1 TP53 MUC1 KRT7 KRT20 KRT19
7 papillary adenoma 30.0 VIM TP53 KRT7
8 cholangiolocellular carcinoma 29.8 MUC1 KRT19 EZH2 CDKN2A
9 hemangioma 29.7 VIM TP53 MUC1 KRT7
10 hepatoblastoma 29.6 TP53 KRT7 KRT19
11 colorectal adenocarcinoma 29.6 TP53 MUC1 KRT7 KRT20 CDKN2A
12 cavernous hemangioma 29.3 VIM MUC1 KRT7 KRT20 KRT19
13 renal cell carcinoma, nonpapillary 28.9 VIM TP53 MUC1 KRT7 KRT20 KRT19
14 cholangiocarcinoma 28.8 TP53 NCAM1 MUC1 KRT7 KRT20 KRT19
15 bile duct cancer 28.4 TP53 NCAM1 MUC1 KRT7 KRT20 KRT19
16 extrahepatic bile duct adenoma 11.5
17 extrahepatic bile duct papillary adenoma 11.2
18 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.4
19 scrotum paget's disease 10.4 MUC1 KRT7
20 gallbladder signet ring cell adenocarcinoma 10.4 MUC1 KRT7
21 nephrogenic adenoma 10.4 MUC1 KRT7
22 mucinous intrahepatic cholangiocarcinoma 10.4 MUC1 KRT7
23 middle ear adenoma 10.4 MUC1 KRT7
24 bile duct cystadenocarcinoma 10.4 MUC1 KRT7
25 biliary papillomatosis 10.3 MUC1 KRT7
26 bile duct mucoepidermoid carcinoma 10.3 MUC1 KRT7
27 cervical basaloid squamous cell carcinoma 10.3 KRT7 CDKN2A
28 inverted transitional papilloma 10.3 KRT7 CDKN2A
29 anal canal paget's disease 10.3 KRT7 CDKN2A
30 cervical adenoid cystic carcinoma 10.3 KRT7 CDKN2A
31 malignant peritoneal mesothelioma 10.3 MUC1 CDKN2A
32 vulvar eccrine porocarcinoma 10.3 MUC1 CDKN2A
33 papillary squamous carcinoma 10.3 KRT7 CDKN2A
34 urethral villous adenoma 10.3 KRT7 KRT20
35 bladder benign neoplasm 10.3 KRT7 KRT20
36 nephrogenic adenoma of urinary bladder 10.3 KRT7 KRT20
37 gallbladder adenoma 10.3 KRT7 CDKN2A
38 vulva adenocarcinoma 10.3 KRT7 KRT20
39 female urethral cancer 10.3 KRT7 KRT20
40 cystitis cystica 10.3 KRT7 KRT20
41 epithelioid trophoblastic tumor 10.3 MUC1 KRT7
42 mucinous ovarian cystadenoma 10.3 KRT7 KRT20
43 rectosigmoid junction neoplasm 10.3 KRT7 KRT20
44 transverse colon cancer 10.3 KRT7 KRT20
45 sigmoid neoplasm 10.3 KRT7 KRT20
46 posterior fossa ependymoma 10.3 EZH2 CDKN2A
47 endosalpingiosis 10.3 MUC1 KRT7
48 krukenberg carcinoma 10.3 KRT7 KRT20
49 eyelid carcinoma 10.3 KRT7 KRT20
50 jejunal neoplasm 10.3 KRT7 KRT20

Graphical network of the top 20 diseases related to Bile Duct Adenoma:



Diseases related to Bile Duct Adenoma

Symptoms & Phenotypes for Bile Duct Adenoma

Drugs & Therapeutics for Bile Duct Adenoma

Drugs for Bile Duct Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Cola

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Endobiliairy Radiofrequency (Probe Habib TM EndoHPB) for the Destruction of Residual Endo Biliairy Dysplastic Buds After Endoscopic Ampullectomy: Prospective Multicenter Study Completed NCT02825524
2 The Effects of An Addition of Water Enema to PEG for Colon Preparation: A Randomized Controlled Trial Completed NCT03270046
3 Volumetric Laser Endomicroscopy's (VLE) Diagnostic Accuracy Validation Study: Impact on Clinical Management Study Enrolling by invitation NCT03951324

Search NIH Clinical Center for Bile Duct Adenoma

Cochrane evidence based reviews: adenoma, bile duct

Genetic Tests for Bile Duct Adenoma

Anatomical Context for Bile Duct Adenoma

The Foundational Model of Anatomy Ontology organs/tissues related to Bile Duct Adenoma:

19
A Fibrous Stroma

MalaCards organs/tissues related to Bile Duct Adenoma:

40
Colon, Liver, Pancreas

Publications for Bile Duct Adenoma

Articles related to Bile Duct Adenoma:

(show top 50) (show all 104)
# Title Authors PMID Year
1
Atypical bile duct adenoma, clear cell type: a previously undescribed tumor of the liver. 54 61
11420469 2001
2
Bile duct adenoma may be a precursor lesion of small duct type intrahepatic cholangiocarcinoma. 61
33405289 2021
3
Hepatic nodules with arterial phase hyperenhancement and washout on enhanced computed tomography/magnetic resonance imaging: how to avoid pitfalls. 61
32377756 2020
4
Utility of DNA flow cytometry in distinguishing between malignant and benign intrahepatic biliary lesions. 61
32296928 2020
5
Bile duct adenoma: imaging features and radiologic-pathologic correlation. 61
32128668 2020
6
Cholangiocarcinoma: Classification, Histopathology and Molecular Carcinogenesis. 61
30448973 2020
7
Pediatric intrahepatic bile duct adenoma - rare liver tumor: A case report. 61
31798791 2019
8
Intrahepatic bile duct adenoma in a patient with gastric cancer. 61
31149539 2019
9
Single-operator cholangioscopy for diagnosis of cholangioadenoma (bile duct adenoma) and its potential impact on surgical management. 61
30410950 2018
10
Imaging features of bile duct adenoma: case series and review of literature. 61
30211677 2018
11
A Rare Case of Incidental Common Bile Duct Adenoma-Endoscopic Ultrasound Evaluation 61
29588259 2018
12
False Positive Diagnosis of Hepatocellular Carcinoma in Liver Resection Patients. 61
28049244 2017
13
Elevated ΔNp63α Levels Facilitate Epidermal and Biliary Oncogenic Transformation. 61
27725202 2017
14
Proliferative index facilitates distinction between benign biliary lesions and intrahepatic cholangiocarcinoma. 61
27396933 2016
15
Bile duct adenoma in patient with chronic hepatitis C: As a benign neoplasm by pathological and imaging studies. 61
27663997 2016
16
Resolution of Bile Duct Adenoma over Follow-up Period; A Case Report. 61
27957298 2016
17
Albumin expression distinguishes bile duct adenomas from metastatic adenocarcinoma. 61
26841202 2016
18
Novel immunohistochemical markers differentiate intrahepatic cholangiocarcinoma from benign bile duct lesions. 61
26729014 2016
19
A Glasgow Tipple-transjugular intrahepatic portosystemic shunt insertion prior to Whipple resection. 61
27177892 2016
20
Adenomas involving the extrahepatic biliary tree are rare but have an aggressive clinical course. 61
26878036 2016
21
Tubular adenoma of the common bile duct with uptake in 18F-FDG PET: A case report. 61
26870353 2016
22
Intrahepatic bile duct adenoma in a patient with chronic hepatitis B accompanied by elevation of alpha-fetoprotein. 61
26770929 2015
23
Intrahepatic Cholangiocarcinoma with Ductal Plate Malformation-like Feature Associated with Bile Duct Adenoma. 61
26265688 2015
24
Clinical and biological significance of precursor lesions of intrahepatic cholangiocarcinoma. 61
26557948 2015
25
Bile duct adenoma (hamartoma of peribiliary glands): Importance of an adequate diagnosis. 61
24125022 2015
26
Magnetic Resonance Imaging Findings of Intrahepatic Bile Duct Adenoma: A Report of 4 Cases. 61
26248149 2015
27
Bile duct adenoma should not be designated as a reactive process. 61
25727261 2015
28
Cellular senescence in biliary pathology. Special emphasis on expression of a polycomb group protein EZH2 and a senescent marker p16INK4a in bile ductular tumors and lesions. 61
25289642 2015
29
Intrahepatic bile duct adenoma (peribiliary gland hamartoma): a case report and review of literature. 61
26191317 2015
30
Bile duct adenoma and von Meyenburg complex-like duct arising in hepatitis and cirrhosis: pathogenesis and histological characteristics. 61
25329860 2014
31
RE: Diffusion-weighted MRI in intrahepatic bile duct adenoma arising from the cirrhotic liver. 61
24843248 2014
32
Bile duct adenoma: a case report and literature review. 61
24767257 2014
33
Immunostaining for polycomb group protein EZH2 and senescent marker p16INK4a may be useful to differentiate cholangiolocellular carcinoma from ductular reaction and bile duct adenoma. 61
24487593 2014
34
Cytopathologic, histopathologic, and immunohistochemical features of intrahepatic clear cell bile duct adenoma: a case report and review of the literature. 61
24955270 2014
35
Bile duct adenoma with oncocytic features. 61
24592348 2014
36
What are the precursor and early lesions of peripheral intrahepatic cholangiocarcinoma? 61
24860673 2014
37
A new peroral mother-baby endoscope system for biliary tract disorders. 61
24527177 2014
38
Diffusion-weighted MRI in intrahepatic bile duct adenoma arising from the cirrhotic liver. 61
24043970 2013
39
Ultrasonography of intrahepatic bile duct adenoma with renal cell carcinoma: correlation with pathology. 61
27277244 2013
40
Intrahepatic bile duct adenoma with oncocytic features. 61
22891770 2013
41
Intrahepatic bile duct adenoma mimicking hepatic metastasis: case report and review of the literature. 61
23666160 2013
42
A combination of snare polypectomy and apc therapy for prolapsing common bile duct adenoma. 61
23687608 2012
43
Comparison of three-dimensional negative-contrast CT cholangiopancreatography with three-dimensional MR cholangiopancreatography for the diagnosis of obstructive biliary diseases. 61
21377820 2012
44
A case of very large intrahepatic bile duct adenoma followed for 7 years. 61
22574289 2012
45
Adenoma-carcinoma sequence in intrahepatic cholangiocarcinoma. 61
22326450 2012
46
Incidental removal of distal common bile duct adenoma after plastic stent placement. 61
22396252 2012
47
Bile duct adenoma causing recurrent cholangitis: diagnosis and management with targeted Spyglass access and radiofrequency ablation. 61
22933260 2012
48
Diagnostic utility of CD10 in benign and malignant extrahepatic bile duct lesions. 61
21989348 2012
49
Intraductal papillary neoplasm arising from peribiliary glands connecting with the inferior branch of the bile duct of the anterior segment of the liver. 61
22126388 2011
50
Common bile duct adenoma: case report and brief review of literature. 61
21150400 2010

Variations for Bile Duct Adenoma

Expression for Bile Duct Adenoma

Search GEO for disease gene expression data for Bile Duct Adenoma.

Pathways for Bile Duct Adenoma

GO Terms for Bile Duct Adenoma

Cellular components related to Bile Duct Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 8.92 VIM KRT7 KRT20 KRT19

Biological processes related to Bile Duct Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament organization GO:0045109 9.37 VIM KRT20
2 cornification GO:0070268 9.33 KRT7 KRT20 KRT19
3 replicative senescence GO:0090399 9.32 TP53 CDKN2A
4 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.26 TP53 MUC1
5 viral process GO:0016032 9.02 VIM TP53 NCAM1 KRT7 KRT19
6 positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0036003 8.96 TP53 MUC1

Molecular functions related to Bile Duct Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 9.33 VIM KRT20 KRT19
2 MDM2/MDM4 family protein binding GO:0097371 8.96 TP53 CDKN2A
3 p53 binding GO:0002039 8.8 TP53 MUC1 CDKN2A

Sources for Bile Duct Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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