Bile Duct Cystadenoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Bile Duct Cystadenoma

MalaCards integrated aliases for Bile Duct Cystadenoma:

Name: Bile Duct Cystadenoma ¹² ¹⁵ ⁷¹

Cystadenoma of the Bile Duct ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases Liver diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5384

NCIt ⁴⁹ C4129

SNOMED-CT ⁶⁷ 83025009

UMLS ⁷¹ C0334285

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Summaries for Bile Duct Cystadenoma

Disease Ontology : ¹² A biliary tract benign neoplasm that is located in the bile duct and derives from epithelial cells.

MalaCards based summary : Bile Duct Cystadenoma, also known as cystadenoma of the bile duct, is related to intrahepatic bile duct cystadenoma and extrahepatic bile duct cystadenoma, and has symptoms including abdominal pain and icterus. An important gene associated with Bile Duct Cystadenoma is PER3 (Period Circadian Regulator 3), and among its related pathways/superpathways are Circadian rythm related genes and Integrated Breast Cancer Pathway. Affiliated tissues include bile duct and liver, and related phenotypes are homeostasis/metabolism and nervous system

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Related Diseases for Bile Duct Cystadenoma

Diseases related to Bile Duct Cystadenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 24)

#	Related Disease	Score	Top Affiliating Genes
1	intrahepatic bile duct cystadenoma	12.5
2	extrahepatic bile duct cystadenoma	12.5
3	cystadenoma	10.3
4	congenital heart defects, hamartomas of tongue, and polysyndactyly	10.1
5	bipolar i disorder	10.0	PER3 ARNTL
6	delayed sleep phase disorder	9.9	PER3 CLOCK ARNTL
7	advanced sleep phase syndrome	9.8	PER3 CLOCK ARNTL
8	sleep disorder	9.8	PER3 CLOCK ARNTL
9	scrotum squamous cell carcinoma	9.7	CHEK2 ATM
10	major depressive disorder	9.7	PER3 CLOCK ARNTL
11	t-cell prolymphocytic leukemia	9.7	CHEK2 ATM
12	telangiectasis	9.6	CHEK2 ATM
13	congenital hypoplastic anemia	9.5	CHEK2 ATM
14	female breast cancer	9.5	ESR1 ATM
15	nijmegen breakage syndrome	9.4	CHEK2 ATM
16	bilateral breast cancer	9.3	ESR1 CHEK2 ATM
17	sporadic breast cancer	9.3	ESR1 CHEK2 ATM
18	autosomal genetic disease	9.3	ESR1 CHEK2 ATM
19	ovary adenocarcinoma	9.2	ESR1 ATM
20	rare breast tumor	9.2	ESR1 CHEK2 ATM
21	ovarian disease	9.2	ESR1 CHEK2 ATM
22	melanoma, cutaneous malignant 1	9.2	TCHP CHEK2 ATM
23	li-fraumeni syndrome	8.9	TCHP ESR1 CHEK2 ATM
24	leukemia, acute myeloid	8.8	TCHP ESR1 CHEK2 ATM

Graphical network of the top 20 diseases related to Bile Duct Cystadenoma:

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Symptoms & Phenotypes for Bile Duct Cystadenoma

UMLS symptoms related to Bile Duct Cystadenoma:

abdominal pain, icterus

MGI Mouse Phenotypes related to Bile Duct Cystadenoma:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	9.5	ARNTL ATM CD200 CHEK2 CLOCK ESR1
2	nervous system	MP:0003631	9.17	ARNTL ATM CD200 CHEK2 CLOCK ESR1

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Drugs & Therapeutics for Bile Duct Cystadenoma

Search Clinical Trials , NIH Clinical Center for Bile Duct Cystadenoma

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Genetic Tests for Bile Duct Cystadenoma

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Anatomical Context for Bile Duct Cystadenoma

The Foundational Model of Anatomy Ontology organs/tissues related to Bile Duct Cystadenoma:

¹⁹

Bile Duct

MalaCards organs/tissues related to Bile Duct Cystadenoma:

⁴⁰

Liver

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Publications for Bile Duct Cystadenoma

Articles related to Bile Duct Cystadenoma:

#	Title	Authors	PMID	Year
1	Definitive diagnosis of a duplicate gallbladder can only be made intraoperatively: report of a case. ⁶¹	Ozaki N...Baba H	26185884	2014
2	Adult mesenchymal hamartoma of the liver mimicking bile duct cystadenoma. ⁶¹	Yamamoto M...Matsumoto Y	7951866	1994
3	Biliary obstruction due to intraductal tumor. ⁶¹	Smith JA...Gibson RN	2548467	1989
4	[Surgically removed bile duct cystadenoma]. ⁶¹	Skaliczki J...Altorjay I	5212262	1968
5	Bile duct cystadenoma of the liver. ⁶¹	Snedecor PA	6027619	1967
6	[Benign tumor of biliary tract papillary cystadenoma of the bile duct]. ⁶¹	FERNANDEZ TASENDE DJ	13344312	1956

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Genes for Bile Duct Cystadenoma

Genes related to Bile Duct Cystadenoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PER3	Period Circadian Regulator 3	Protein Coding	5.31	DISEASES inferred ¹⁵
2	CLOCK	Clock Circadian Regulator	Protein Coding	5.06	DISEASES inferred ¹⁵
3	CD200	CD200 Molecule	Protein Coding	4.82	DISEASES inferred ¹⁵
4	ARNTL	Aryl Hydrocarbon Receptor Nuclear Translocator Like	Protein Coding	4.82	DISEASES inferred ¹⁵
5	CHEK2	Checkpoint Kinase 2	Protein Coding	4.27	DISEASES inferred ¹⁵
6	TCHP	Trichoplein Keratin Filament Binding	Protein Coding	4.13	DISEASES inferred ¹⁵
7	ATM	ATM Serine/Threonine Kinase	Protein Coding	3.81	DISEASES inferred ¹⁵
8	ESR1	Estrogen Receptor 1	Protein Coding	3.36	DISEASES inferred ¹⁵

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Variations for Bile Duct Cystadenoma

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Expression for Bile Duct Cystadenoma

Search GEO for disease gene expression data for Bile Duct Cystadenoma.

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Pathways for Bile Duct Cystadenoma

Pathways related to Bile Duct Cystadenoma according to GeneCards Suite gene sharing:

(show all 16)

#	Super pathways	Score	Top Affiliating Genes
1	Circadian rythm related genes ¹	11.9	PER3 CLOCK ARNTL
2	Integrated Breast Cancer Pathway ¹	11.69	ESR1 CHEK2 ATM
3	Regulation of Telomerase ¹	11.38	ESR1 ATM
4	Pathways Affected in Adenoid Cystic Carcinoma ¹	11.37	CHEK2 ATM
5	p53 pathway ¹	11.31	CHEK2 ATM
6	Diurnally Regulated Genes with Circadian Orthologs ¹	11.21	CLOCK ARNTL
7	Integrated Cancer Pathway ¹	11.17	CHEK2 ATM
8	ATM Signaling Network in Development and Disease ¹	11.16	CHEK2 ATM
9	Cell cycle Role of 14-3-3 proteins in cell cycle regulation ²² Show member pathways 14-3-3 and Cell Cycle Regulation ⁶³	11.13	CHEK2 ATM
10	DNA damage_ATM/ATR regulation of G1/S checkpoint ²²	11.1	CHEK2 ATM
11	FOXM1 transcription factor network ¹	11	ESR1 CHEK2
12	Circadian rhythm ³⁶ Show member pathways Circadian Clock in Mammals ⁶³	10.77	PER3 CLOCK ARNTL
13	Gemtuzumab ozogamicin Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	10.73	CHEK2 ATM
14	Circadian rhythm pathway ¹	10.4	CLOCK ARNTL
15	Melatonin metabolism and effects ¹	10.37	PER3 CLOCK ARNTL
16	Metabolic States and Circadian Oscillators ⁶³ Show member pathways lactate fermentation (reoxidation of cytosolic NADH) ¹	10.23	CLOCK ARNTL

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GO Terms for Bile Duct Cystadenoma

Cellular components related to Bile Duct Cystadenoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	chromosome, telomeric region	GO:0000781	8.96	CHEK2 ATM
2	chromatoid body	GO:0033391	8.62	CLOCK ARNTL

Biological processes related to Bile Duct Cystadenoma according to GeneCards Suite gene sharing:

(show all 16)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription, DNA-templated	GO:0045893	9.81	ESR1 CLOCK CHEK2 ARNTL
2	rhythmic process	GO:0048511	9.65	PER3 CLOCK ARNTL
3	regulation of insulin secretion	GO:0050796	9.56	CLOCK ARNTL
4	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	GO:0006977	9.55	CHEK2 ATM
5	intrinsic apoptotic signaling pathway in response to DNA damage	GO:0008630	9.54	CHEK2 ATM
6	circadian rhythm	GO:0007623	9.54	PER3 CLOCK ARNTL
7	cellular response to gamma radiation	GO:0071480	9.52	CHEK2 ATM
8	regulation of protein catabolic process	GO:0042176	9.49	CHEK2 ARNTL
9	replicative senescence	GO:0090399	9.46	CHEK2 ATM
10	response to redox state	GO:0051775	9.43	CLOCK ARNTL
11	DNA damage induced protein phosphorylation	GO:0006975	9.4	CHEK2 ATM
12	circadian regulation of gene expression	GO:0032922	9.33	PER3 CLOCK ARNTL
13	negative regulation of glucocorticoid receptor signaling pathway	GO:2000323	9.32	CLOCK ARNTL
14	regulation of hair cycle	GO:0042634	9.26	CLOCK ARNTL
15	regulation of type B pancreatic cell development	GO:2000074	8.96	CLOCK ARNTL
16	DNA damage checkpoint	GO:0000077	8.8	CLOCK CHEK2 ATM

Molecular functions related to Bile Duct Cystadenoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	E-box binding	GO:0070888	8.96	CLOCK ARNTL
2	protein dimerization activity	GO:0046983	8.8	CLOCK ATM ARNTL

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Sources for Bile Duct Cystadenoma

¹ BioSystems

² BitterDB

³ CDC

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²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

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³¹ HPO

³² ICD10

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³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

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⁴⁷ NCBI Bookshelf

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⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

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⁵⁹ PathCards

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⁶¹ PubMed

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⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia