MCID: BLD035
MIFTS: 29

Bile Duct Cystadenoma

Categories: Cancer diseases, Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Bile Duct Cystadenoma

MalaCards integrated aliases for Bile Duct Cystadenoma:

Name: Bile Duct Cystadenoma 12 15 71
Cystadenoma of the Bile Duct 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5384
NCIt 50 C4129
SNOMED-CT 67 83025009
UMLS 71 C0334285

Summaries for Bile Duct Cystadenoma

Disease Ontology : 12 A biliary tract benign neoplasm that is located in the bile duct and derives from epithelial cells.

MalaCards based summary : Bile Duct Cystadenoma, also known as cystadenoma of the bile duct, is related to intrahepatic bile duct cystadenoma and extrahepatic bile duct cystadenoma, and has symptoms including abdominal pain and icterus. An important gene associated with Bile Duct Cystadenoma is PER3 (Period Circadian Regulator 3), and among its related pathways/superpathways are Chks in Checkpoint Regulation and Circadian rythm related genes. Affiliated tissues include bile duct, and related phenotypes are cardiovascular system and adipose tissue

Related Diseases for Bile Duct Cystadenoma

Diseases related to Bile Duct Cystadenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 intrahepatic bile duct cystadenoma 11.3
2 extrahepatic bile duct cystadenoma 11.3
3 cystadenoma 10.3
4 gum cancer 10.2 PER3 ARNTL
5 bipolar i disorder 10.1 PER3 ARNTL
6 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.0
7 advanced sleep phase syndrome, familial, 1 10.0 PER3 CLOCK ARNTL
8 advanced sleep phase syndrome 10.0 PER3 CLOCK ARNTL
9 delayed sleep phase disorder 10.0 PER3 CLOCK ARNTL
10 sleep disorder 10.0 PER3 CLOCK ARNTL
11 nonmucinous bronchioloalveolar adenocarcinoma 10.0 ESR2 ESR1
12 postmenopausal atrophic vaginitis 10.0 ESR2 ESR1
13 vaginitis 10.0 ESR2 ESR1
14 gender identity disorder 10.0 ESR2 ESR1
15 progesterone resistance 10.0 ESR2 ESR1
16 vaginal cancer 9.9 ESR2 ESR1
17 progesterone-receptor positive breast cancer 9.9 ESR2 ESR1
18 estrogen excess 9.9 ESR2 ESR1
19 endometriosis of ovary 9.9 ESR2 ESR1
20 dental fluorosis 9.9 ESR2 ESR1
21 lobular neoplasia 9.9 ESR2 ESR1
22 thoracic benign neoplasm 9.9 ESR2 ESR1
23 breast benign neoplasm 9.9 ESR2 ESR1
24 testicular germ cell cancer 9.9 ESR2 ESR1
25 uterine benign neoplasm 9.9 ESR2 ESR1
26 cervical adenoma malignum 9.9 CHEK2 ATM
27 reproductive organ benign neoplasm 9.9 ESR2 ESR1
28 idiopathic scoliosis 9.9 ESR2 ESR1
29 aromatase excess syndrome 9.9 ESR2 ESR1
30 t-cell prolymphocytic leukemia 9.9 CHEK2 ATM
31 synchronous bilateral breast carcinoma 9.8 ESR1 ATM
32 adenomyosis 9.8 ESR2 ESR1
33 pelvic organ prolapse 9.8 ESR2 ESR1
34 teeth hard tissue disease 9.8 ESR2 ESR1
35 telangiectasis 9.8 CHEK2 ATM
36 gynecomastia 9.8 ESR2 ESR1
37 major depressive disorder 9.7 PER3 ESR1 CLOCK ARNTL
38 primary pigmented nodular adrenocortical disease 9.7 ESR2 ESR1
39 female breast cancer 9.6 ESR1 ATM
40 bilateral breast cancer 9.6 ESR1 CHEK2 ATM
41 melanoma, cutaneous malignant 1 9.6 TCHP CHEK2 ATM
42 gastric cancer, hereditary diffuse 9.5 CHEK2 ATM
43 autosomal genetic disease 9.5 ESR2 ESR1 ATM
44 autosomal recessive disease 9.5 ESR2 ESR1 ATM
45 li-fraumeni syndrome 9.3 TCHP ESR1 CHEK2 ATM
46 skin carcinoma 9.3 TCHP ESR1 CHEK2 ATM
47 sporadic breast cancer 9.3 ESR2 ESR1 CHEK2 ATM
48 leukemia, acute myeloid 9.3 TCHP ESR1 CHEK2 ATM
49 premature menopause 9.3 ESR2 ESR1 CHEK2 ATM
50 disease of mental health 8.9 PER3 ESR2 ESR1 CLOCK ATM ARNTL

Graphical network of the top 20 diseases related to Bile Duct Cystadenoma:



Diseases related to Bile Duct Cystadenoma

Symptoms & Phenotypes for Bile Duct Cystadenoma

UMLS symptoms related to Bile Duct Cystadenoma:


abdominal pain, icterus

MGI Mouse Phenotypes related to Bile Duct Cystadenoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.73 ARNTL ATM CHEK2 CLOCK ESR1 ESR2
2 adipose tissue MP:0005375 9.72 ARNTL ATM CLOCK ESR1 ESR2
3 endocrine/exocrine gland MP:0005379 9.63 ARNTL ATM CHEK2 CLOCK ESR1 ESR2
4 nervous system MP:0003631 9.5 ARNTL ATM CHEK2 CLOCK ESR1 ESR2
5 reproductive system MP:0005389 9.1 ARNTL ATM CHEK2 CLOCK ESR1 ESR2

Drugs & Therapeutics for Bile Duct Cystadenoma

Search Clinical Trials , NIH Clinical Center for Bile Duct Cystadenoma

Genetic Tests for Bile Duct Cystadenoma

Anatomical Context for Bile Duct Cystadenoma

The Foundational Model of Anatomy Ontology organs/tissues related to Bile Duct Cystadenoma:

19
Bile Duct

Publications for Bile Duct Cystadenoma

Articles related to Bile Duct Cystadenoma:

# Title Authors PMID Year
1
Definitive diagnosis of a duplicate gallbladder can only be made intraoperatively: report of a case. 61
26185884 2014
2
Adult mesenchymal hamartoma of the liver mimicking bile duct cystadenoma. 61
7951866 1994
3
Biliary obstruction due to intraductal tumor. 61
2548467 1989
4
[Surgically removed bile duct cystadenoma]. 61
5212262 1968
5
Bile duct cystadenoma of the liver. 61
6027619 1967
6
[Benign tumor of biliary tract papillary cystadenoma of the bile duct]. 61
13344312 1956

Variations for Bile Duct Cystadenoma

Expression for Bile Duct Cystadenoma

Search GEO for disease gene expression data for Bile Duct Cystadenoma.

Pathways for Bile Duct Cystadenoma

Pathways related to Bile Duct Cystadenoma according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.16 ESR2 ESR1 CHEK2 ATM
3 11.77 ESR1 CHEK2 ATM
4 11.36 CHEK2 ATM
5 11.27 CLOCK ARNTL
6 11.24 CHEK2 ATM
7 11.23 CHEK2 ATM
8
Show member pathways
11.21 CHEK2 ATM
9 11.19 CHEK2 ATM
10 11.1 ESR1 CHEK2
11 11.03 ESR2 ATM
12 10.96 ESR2 ESR1
13 10.91 ESR2 ESR1
14 10.82 ESR2 ESR1
15 10.79 CHEK2 ATM
16
Show member pathways
10.77 PER3 CLOCK ARNTL
17 10.51 CLOCK ARNTL
18
Show member pathways
10.4 CLOCK ARNTL
19 10.37 PER3 CLOCK ARNTL
20 9.76 ESR2 ESR1

GO Terms for Bile Duct Cystadenoma

Cellular components related to Bile Duct Cystadenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatoid body GO:0033391 8.62 CLOCK ARNTL

Biological processes related to Bile Duct Cystadenoma according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.93 ESR2 ESR1 CLOCK CHEK2 ARNTL
2 positive regulation of transcription by RNA polymerase II GO:0045944 9.88 ESR2 ESR1 CLOCK ATM ARNTL
3 rhythmic process GO:0048511 9.67 PER3 CLOCK ARNTL
4 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.58 CHEK2 ATM
5 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.57 CHEK2 ATM
6 cellular response to estradiol stimulus GO:0071392 9.56 ESR2 ESR1
7 cellular response to gamma radiation GO:0071480 9.55 CHEK2 ATM
8 positive regulation of transcription, DNA-templated GO:0045893 9.55 ESR2 ESR1 CLOCK CHEK2 ARNTL
9 intracellular estrogen receptor signaling pathway GO:0030520 9.52 ESR2 ESR1
10 replicative senescence GO:0090399 9.51 CHEK2 ATM
11 response to redox state GO:0051775 9.46 CLOCK ARNTL
12 intracellular steroid hormone receptor signaling pathway GO:0030518 9.43 ESR2 ESR1
13 circadian regulation of gene expression GO:0032922 9.43 PER3 CLOCK ARNTL
14 DNA damage induced protein phosphorylation GO:0006975 9.4 CHEK2 ATM
15 negative regulation of glucocorticoid receptor signaling pathway GO:2000323 9.37 CLOCK ARNTL
16 regulation of hair cycle GO:0042634 9.32 CLOCK ARNTL
17 regulation of type B pancreatic cell development GO:2000074 8.96 CLOCK ARNTL
18 DNA damage checkpoint GO:0000077 8.8 CLOCK CHEK2 ATM

Molecular functions related to Bile Duct Cystadenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity GO:0003700 9.62 ESR2 ESR1 CLOCK ARNTL
2 sequence-specific DNA binding GO:0043565 9.46 ESR2 ESR1 CLOCK ARNTL
3 nuclear receptor activity GO:0004879 9.43 ESR2 ESR1
4 E-box binding GO:0070888 9.4 CLOCK ARNTL
5 steroid binding GO:0005496 9.37 ESR2 ESR1
6 steroid hormone receptor activity GO:0003707 9.26 ESR2 ESR1
7 estrogen receptor activity GO:0030284 8.96 ESR2 ESR1
8 estrogen response element binding GO:0034056 8.62 ESR2 ESR1

Sources for Bile Duct Cystadenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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