MCID: BLD035
MIFTS: 30

Bile Duct Cystadenoma

Categories: Cancer diseases, Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Bile Duct Cystadenoma

MalaCards integrated aliases for Bile Duct Cystadenoma:

Name: Bile Duct Cystadenoma 12 15 71
Cystadenoma of the Bile Duct 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5384
NCIt 49 C4129
SNOMED-CT 67 83025009
UMLS 71 C0334285

Summaries for Bile Duct Cystadenoma

Disease Ontology : 12 A biliary tract benign neoplasm that is located in the bile duct and derives from epithelial cells.

MalaCards based summary : Bile Duct Cystadenoma, also known as cystadenoma of the bile duct, is related to intrahepatic bile duct cystadenoma and extrahepatic bile duct cystadenoma, and has symptoms including abdominal pain and icterus. An important gene associated with Bile Duct Cystadenoma is PER3 (Period Circadian Regulator 3), and among its related pathways/superpathways are Chks in Checkpoint Regulation and Circadian rythm related genes. Affiliated tissues include bile duct and liver, and related phenotypes are behavior/neurological and cellular

Related Diseases for Bile Duct Cystadenoma

Diseases related to Bile Duct Cystadenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 intrahepatic bile duct cystadenoma 12.5
2 extrahepatic bile duct cystadenoma 12.5
3 cystadenoma 10.3
4 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.1
5 malignant spiradenoma 10.1 TCHP CD200
6 delayed sleep phase disorder 10.0 PER3 CLOCK ARNTL
7 advanced sleep phase syndrome 10.0 PER3 CLOCK ARNTL
8 sleep disorder 10.0 PER3 CLOCK ARNTL
9 nonmucinous bronchioloalveolar adenocarcinoma 9.9 ESR2 ESR1
10 postmenopausal atrophic vaginitis 9.9 ESR2 ESR1
11 vaginitis 9.9 ESR2 ESR1
12 progesterone resistance 9.9 ESR2 ESR1
13 gender identity disorder 9.9 ESR2 ESR1
14 vaginal cancer 9.9 ESR2 ESR1
15 progesterone-receptor positive breast cancer 9.9 ESR2 ESR1
16 estrogen excess 9.9 ESR2 ESR1
17 aromatase excess syndrome 9.8 ESR2 ESR1
18 endometriosis of ovary 9.8 ESR2 ESR1
19 dental fluorosis 9.8 ESR2 ESR1
20 lobular neoplasia 9.8 ESR2 ESR1
21 cervical adenoma malignum 9.8 CHEK2 ATM
22 testicular germ cell cancer 9.8 ESR2 ESR1
23 uterine benign neoplasm 9.7 ESR2 ESR1
24 t-cell prolymphocytic leukemia 9.7 CHEK2 ATM
25 reproductive organ benign neoplasm 9.7 ESR2 ESR1
26 bipolar i disorder 9.7 PER3 ARNTL
27 adenomyosis 9.7 ESR2 ESR1
28 amelogenesis imperfecta, type ig 9.6 ESR2 ESR1
29 telangiectasis 9.6 CHEK2 ATM
30 major depressive disorder 9.6 PER3 ESR1 CLOCK ARNTL
31 pelvic organ prolapse 9.5 ESR2 ESR1
32 bilateral breast cancer 9.4 ESR1 CHEK2 ATM
33 melanoma, cutaneous malignant 1 9.4 TCHP CHEK2 ATM
34 rare breast tumor 9.3 ESR1 CHEK2 ATM
35 ovarian serous cystadenocarcinoma 9.3 ESR2 ESR1 ATM
36 autosomal genetic disease 9.2 ESR2 ESR1 ATM
37 autosomal recessive disease 9.2 ESR2 ESR1 ATM
38 li-fraumeni syndrome 9.0 TCHP ESR1 CHEK2 ATM
39 sporadic breast cancer 9.0 ESR2 ESR1 CHEK2 ATM
40 suppression of tumorigenicity 12 9.0 ESR2 ESR1 CHEK2 ATM
41 gastric adenocarcinoma 8.9 ESR2 ESR1 CHEK2 ATM
42 leukemia, acute myeloid 8.9 TCHP ESR1 CHEK2 ATM

Graphical network of the top 20 diseases related to Bile Duct Cystadenoma:



Diseases related to Bile Duct Cystadenoma

Symptoms & Phenotypes for Bile Duct Cystadenoma

UMLS symptoms related to Bile Duct Cystadenoma:


abdominal pain, icterus

MGI Mouse Phenotypes related to Bile Duct Cystadenoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.91 ARNTL ATM CD200 CLOCK ESR1 ESR2
2 cellular MP:0005384 9.87 ARNTL ATM CD200 CHEK2 CLOCK ESR1
3 adipose tissue MP:0005375 9.8 ARNTL ATM CLOCK ESR1 ESR2
4 homeostasis/metabolism MP:0005376 9.76 ARNTL ATM CD200 CHEK2 CLOCK ESR1
5 endocrine/exocrine gland MP:0005379 9.73 ARNTL ATM CHEK2 CLOCK ESR1 ESR2
6 nervous system MP:0003631 9.56 ARNTL ATM CD200 CHEK2 CLOCK ESR1
7 reproductive system MP:0005389 9.1 ARNTL ATM CHEK2 CLOCK ESR1 ESR2

Drugs & Therapeutics for Bile Duct Cystadenoma

Search Clinical Trials , NIH Clinical Center for Bile Duct Cystadenoma

Genetic Tests for Bile Duct Cystadenoma

Anatomical Context for Bile Duct Cystadenoma

The Foundational Model of Anatomy Ontology organs/tissues related to Bile Duct Cystadenoma:

19
Bile Duct

MalaCards organs/tissues related to Bile Duct Cystadenoma:

40
Liver

Publications for Bile Duct Cystadenoma

Articles related to Bile Duct Cystadenoma:

# Title Authors PMID Year
1
Definitive diagnosis of a duplicate gallbladder can only be made intraoperatively: report of a case. 61
26185884 2014
2
Adult mesenchymal hamartoma of the liver mimicking bile duct cystadenoma. 61
7951866 1994
3
Biliary obstruction due to intraductal tumor. 61
2548467 1989
4
[Surgically removed bile duct cystadenoma]. 61
5212262 1968
5
Bile duct cystadenoma of the liver. 61
6027619 1967
6
[Benign tumor of biliary tract papillary cystadenoma of the bile duct]. 61
13344312 1956

Variations for Bile Duct Cystadenoma

Expression for Bile Duct Cystadenoma

Search GEO for disease gene expression data for Bile Duct Cystadenoma.

Pathways for Bile Duct Cystadenoma

Pathways related to Bile Duct Cystadenoma according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.23 ESR2 ESR1 CHEK2 ATM
3 11.77 ESR1 CHEK2 ATM
4 11.27 CLOCK ARNTL
5 11.24 CHEK2 ATM
6 11.23 CHEK2 ATM
7
Show member pathways
11.21 CHEK2 ATM
8 11.19 CHEK2 ATM
9 11.1 ESR1 CHEK2
10 11.03 ESR2 ATM
11 10.96 ESR2 ESR1
12 10.89 ESR2 ESR1
13 10.82 ESR2 ESR1
14 10.79 CHEK2 ATM
15
Show member pathways
10.77 PER3 CLOCK ARNTL
16 10.51 CLOCK ARNTL
17 10.37 PER3 CLOCK ARNTL
18
Show member pathways
10.34 CLOCK ARNTL
19 9.76 ESR2 ESR1

GO Terms for Bile Duct Cystadenoma

Cellular components related to Bile Duct Cystadenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatoid body GO:0033391 8.62 CLOCK ARNTL

Biological processes related to Bile Duct Cystadenoma according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.95 ESR2 ESR1 CLOCK CHEK2 ARNTL
2 rhythmic process GO:0048511 9.67 PER3 CLOCK ARNTL
3 circadian rhythm GO:0007623 9.61 PER3 CLOCK ARNTL
4 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.56 CHEK2 ATM
5 positive regulation of transcription, DNA-templated GO:0045893 9.55 ESR2 ESR1 CLOCK CHEK2 ARNTL
6 cellular response to gamma radiation GO:0071480 9.54 CHEK2 ATM
7 intracellular estrogen receptor signaling pathway GO:0030520 9.52 ESR2 ESR1
8 regulation of protein catabolic process GO:0042176 9.51 CHEK2 ARNTL
9 replicative senescence GO:0090399 9.48 CHEK2 ATM
10 response to redox state GO:0051775 9.46 CLOCK ARNTL
11 circadian regulation of gene expression GO:0032922 9.43 PER3 CLOCK ARNTL
12 DNA damage induced protein phosphorylation GO:0006975 9.4 CHEK2 ATM
13 negative regulation of glucocorticoid receptor signaling pathway GO:2000323 9.37 CLOCK ARNTL
14 regulation of hair cycle GO:0042634 9.32 CLOCK ARNTL
15 regulation of type B pancreatic cell development GO:2000074 8.96 CLOCK ARNTL
16 DNA damage checkpoint GO:0000077 8.8 CLOCK CHEK2 ATM

Molecular functions related to Bile Duct Cystadenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.76 ESR2 ESR1 CLOCK ARNTL
2 sequence-specific DNA binding GO:0043565 9.67 ESR2 ESR1 CLOCK ARNTL
3 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.56 ESR2 ESR1 CLOCK ARNTL
4 steroid hormone receptor activity GO:0003707 9.48 ESR2 ESR1
5 E-box binding GO:0070888 9.43 CLOCK ARNTL
6 nuclear receptor activity GO:0004879 9.4 ESR2 ESR1
7 steroid binding GO:0005496 9.32 ESR2 ESR1
8 estrogen receptor activity GO:0030284 9.16 ESR2 ESR1
9 estrogen response element binding GO:0034056 8.96 ESR2 ESR1
10 repressing transcription factor binding GO:0070491 8.8 ESR2 ESR1 ARNTL

Sources for Bile Duct Cystadenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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