Bile Duct Cystadenoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Bile Duct Cystadenoma

MalaCards integrated aliases for Bile Duct Cystadenoma:

Name: Bile Duct Cystadenoma ¹² ¹⁵ ⁷¹

Cystadenoma of the Bile Duct ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases Liver diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5384

NCIt ⁴⁹ C4129

SNOMED-CT ⁶⁷ 83025009

UMLS ⁷¹ C0334285

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Summaries for Bile Duct Cystadenoma

Disease Ontology : ¹² A biliary tract benign neoplasm that is located in the bile duct and derives from epithelial cells.

MalaCards based summary : Bile Duct Cystadenoma, also known as cystadenoma of the bile duct, is related to intrahepatic bile duct cystadenoma and extrahepatic bile duct cystadenoma, and has symptoms including abdominal pain and icterus. An important gene associated with Bile Duct Cystadenoma is PER3 (Period Circadian Regulator 3), and among its related pathways/superpathways are Chks in Checkpoint Regulation and Circadian rythm related genes. Affiliated tissues include bile duct and liver, and related phenotypes are behavior/neurological and cellular

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Related Diseases for Bile Duct Cystadenoma

Diseases related to Bile Duct Cystadenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)

#	Related Disease	Score	Top Affiliating Genes
1	intrahepatic bile duct cystadenoma	12.5
2	extrahepatic bile duct cystadenoma	12.5
3	cystadenoma	10.3
4	congenital heart defects, hamartomas of tongue, and polysyndactyly	10.1
5	malignant spiradenoma	10.1	TCHP CD200
6	delayed sleep phase disorder	10.0	PER3 CLOCK ARNTL
7	advanced sleep phase syndrome	10.0	PER3 CLOCK ARNTL
8	sleep disorder	10.0	PER3 CLOCK ARNTL
9	nonmucinous bronchioloalveolar adenocarcinoma	9.9	ESR2 ESR1
10	postmenopausal atrophic vaginitis	9.9	ESR2 ESR1
11	vaginitis	9.9	ESR2 ESR1
12	progesterone resistance	9.9	ESR2 ESR1
13	gender identity disorder	9.9	ESR2 ESR1
14	vaginal cancer	9.9	ESR2 ESR1
15	progesterone-receptor positive breast cancer	9.9	ESR2 ESR1
16	estrogen excess	9.9	ESR2 ESR1
17	aromatase excess syndrome	9.8	ESR2 ESR1
18	endometriosis of ovary	9.8	ESR2 ESR1
19	dental fluorosis	9.8	ESR2 ESR1
20	lobular neoplasia	9.8	ESR2 ESR1
21	cervical adenoma malignum	9.8	CHEK2 ATM
22	testicular germ cell cancer	9.8	ESR2 ESR1
23	uterine benign neoplasm	9.7	ESR2 ESR1
24	t-cell prolymphocytic leukemia	9.7	CHEK2 ATM
25	reproductive organ benign neoplasm	9.7	ESR2 ESR1
26	bipolar i disorder	9.7	PER3 ARNTL
27	adenomyosis	9.7	ESR2 ESR1
28	amelogenesis imperfecta, type ig	9.6	ESR2 ESR1
29	telangiectasis	9.6	CHEK2 ATM
30	major depressive disorder	9.6	PER3 ESR1 CLOCK ARNTL
31	pelvic organ prolapse	9.5	ESR2 ESR1
32	bilateral breast cancer	9.4	ESR1 CHEK2 ATM
33	melanoma, cutaneous malignant 1	9.4	TCHP CHEK2 ATM
34	rare breast tumor	9.3	ESR1 CHEK2 ATM
35	ovarian serous cystadenocarcinoma	9.3	ESR2 ESR1 ATM
36	autosomal genetic disease	9.2	ESR2 ESR1 ATM
37	autosomal recessive disease	9.2	ESR2 ESR1 ATM
38	li-fraumeni syndrome	9.0	TCHP ESR1 CHEK2 ATM
39	sporadic breast cancer	9.0	ESR2 ESR1 CHEK2 ATM
40	suppression of tumorigenicity 12	9.0	ESR2 ESR1 CHEK2 ATM
41	gastric adenocarcinoma	8.9	ESR2 ESR1 CHEK2 ATM
42	leukemia, acute myeloid	8.9	TCHP ESR1 CHEK2 ATM

Graphical network of the top 20 diseases related to Bile Duct Cystadenoma:

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Symptoms & Phenotypes for Bile Duct Cystadenoma

UMLS symptoms related to Bile Duct Cystadenoma:

abdominal pain, icterus

MGI Mouse Phenotypes related to Bile Duct Cystadenoma:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	9.91	ARNTL ATM CD200 CLOCK ESR1 ESR2
2	cellular	MP:0005384	9.87	ARNTL ATM CD200 CHEK2 CLOCK ESR1
3	adipose tissue	MP:0005375	9.8	ARNTL ATM CLOCK ESR1 ESR2
4	homeostasis/metabolism	MP:0005376	9.76	ARNTL ATM CD200 CHEK2 CLOCK ESR1
5	endocrine/exocrine gland	MP:0005379	9.73	ARNTL ATM CHEK2 CLOCK ESR1 ESR2
6	nervous system	MP:0003631	9.56	ARNTL ATM CD200 CHEK2 CLOCK ESR1
7	reproductive system	MP:0005389	9.1	ARNTL ATM CHEK2 CLOCK ESR1 ESR2

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Drugs & Therapeutics for Bile Duct Cystadenoma

Search Clinical Trials , NIH Clinical Center for Bile Duct Cystadenoma

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Genetic Tests for Bile Duct Cystadenoma

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Anatomical Context for Bile Duct Cystadenoma

The Foundational Model of Anatomy Ontology organs/tissues related to Bile Duct Cystadenoma:

¹⁹

Bile Duct

MalaCards organs/tissues related to Bile Duct Cystadenoma:

⁴⁰

Liver

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Publications for Bile Duct Cystadenoma

Articles related to Bile Duct Cystadenoma:

#	Title	Authors	PMID	Year
1	Definitive diagnosis of a duplicate gallbladder can only be made intraoperatively: report of a case. ⁶¹	Ozaki N...Baba H	26185884	2014
2	Adult mesenchymal hamartoma of the liver mimicking bile duct cystadenoma. ⁶¹	Yamamoto M...Matsumoto Y	7951866	1994
3	Biliary obstruction due to intraductal tumor. ⁶¹	Smith JA...Gibson RN	2548467	1989
4	[Surgically removed bile duct cystadenoma]. ⁶¹	Skaliczki J...Altorjay I	5212262	1968
5	Bile duct cystadenoma of the liver. ⁶¹	Snedecor PA	6027619	1967
6	[Benign tumor of biliary tract papillary cystadenoma of the bile duct]. ⁶¹	FERNANDEZ TASENDE DJ	13344312	1956

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Genes for Bile Duct Cystadenoma

Genes related to Bile Duct Cystadenoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PER3	Period Circadian Regulator 3	Protein Coding	5.24	DISEASES inferred ¹⁵
2	CLOCK	Clock Circadian Regulator	Protein Coding	4.98	DISEASES inferred ¹⁵
3	CD200	CD200 Molecule	Protein Coding	4.74	DISEASES inferred ¹⁵
4	ARNTL	Aryl Hydrocarbon Receptor Nuclear Translocator Like	Protein Coding	4.73	DISEASES inferred ¹⁵
5	CHEK2	Checkpoint Kinase 2	Protein Coding	4.21	DISEASES inferred ¹⁵
6	TCHP	Trichoplein Keratin Filament Binding	Protein Coding	4.09	DISEASES inferred ¹⁵
7	ESR2	Estrogen Receptor 2	Protein Coding	3.96	DISEASES inferred ¹⁵
8	ATM	ATM Serine/Threonine Kinase	Protein Coding	3.73	DISEASES inferred ¹⁵
9	ESR1	Estrogen Receptor 1	Protein Coding	3.24	DISEASES inferred ¹⁵

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Variations for Bile Duct Cystadenoma

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Expression for Bile Duct Cystadenoma

Search GEO for disease gene expression data for Bile Duct Cystadenoma.

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Pathways for Bile Duct Cystadenoma

Pathways related to Bile Duct Cystadenoma according to GeneCards Suite gene sharing:

(show all 19)

#	Super pathways	Score	Top Affiliating Genes
1	Chks in Checkpoint Regulation ⁶³ Show member pathways DNA Repair Mechanisms ⁶³ Estrogen-mediated S-Phase Entry ⁶³ G2-M Phase Transition ⁶³ Parkinson's Disease Pathway ⁶³ SREBP Proteolysis ⁶³	12.23	ESR2 ESR1 CHEK2 ATM
2	Circadian rythm related genes ¹	11.99	PER3 CLOCK ARNTL
3	Integrated Breast Cancer Pathway ¹	11.77	ESR1 CHEK2 ATM
4	Diurnally Regulated Genes with Circadian Orthologs ¹	11.27	CLOCK ARNTL
5	Integrated Cancer Pathway ¹	11.24	CHEK2 ATM
6	ATM Signaling Network in Development and Disease ¹	11.23	CHEK2 ATM
7	Cell cycle Role of 14-3-3 proteins in cell cycle regulation ²² Show member pathways 14-3-3 and Cell Cycle Regulation ⁶³	11.21	CHEK2 ATM
8	DNA damage_ATM/ATR regulation of G1/S checkpoint ²²	11.19	CHEK2 ATM
9	FOXM1 transcription factor network ¹	11.1	ESR1 CHEK2
10	Ovarian Infertility Genes ¹	11.03	ESR2 ATM
11	Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2 ²²	10.96	ESR2 ESR1
12	Plasma membrane estrogen receptor signaling ¹	10.89	ESR2 ESR1
13	MNAR-PELP1 and Estrogen Receptor Interaction ⁶³	10.82	ESR2 ESR1
14	Gemtuzumab ozogamicin Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	10.79	CHEK2 ATM
15	Circadian rhythm ³⁶ Show member pathways Circadian Clock in Mammals ⁶³	10.77	PER3 CLOCK ARNTL
16	Circadian rhythm pathway ¹	10.51	CLOCK ARNTL
17	Melatonin metabolism and effects ¹	10.37	PER3 CLOCK ARNTL
18	Metabolic States and Circadian Oscillators ⁶³ Show member pathways lactate fermentation (reoxidation of cytosolic NADH) ¹	10.34	CLOCK ARNTL
19	Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics ⁶⁰	9.76	ESR2 ESR1

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GO Terms for Bile Duct Cystadenoma

Cellular components related to Bile Duct Cystadenoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	chromatoid body	GO:0033391	8.62	CLOCK ARNTL

Biological processes related to Bile Duct Cystadenoma according to GeneCards Suite gene sharing:

(show all 16)

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of transcription, DNA-templated	GO:0006355	9.95	ESR2 ESR1 CLOCK CHEK2 ARNTL
2	rhythmic process	GO:0048511	9.67	PER3 CLOCK ARNTL
3	circadian rhythm	GO:0007623	9.61	PER3 CLOCK ARNTL
4	intrinsic apoptotic signaling pathway in response to DNA damage	GO:0008630	9.56	CHEK2 ATM
5	positive regulation of transcription, DNA-templated	GO:0045893	9.55	ESR2 ESR1 CLOCK CHEK2 ARNTL
6	cellular response to gamma radiation	GO:0071480	9.54	CHEK2 ATM
7	intracellular estrogen receptor signaling pathway	GO:0030520	9.52	ESR2 ESR1
8	regulation of protein catabolic process	GO:0042176	9.51	CHEK2 ARNTL
9	replicative senescence	GO:0090399	9.48	CHEK2 ATM
10	response to redox state	GO:0051775	9.46	CLOCK ARNTL
11	circadian regulation of gene expression	GO:0032922	9.43	PER3 CLOCK ARNTL
12	DNA damage induced protein phosphorylation	GO:0006975	9.4	CHEK2 ATM
13	negative regulation of glucocorticoid receptor signaling pathway	GO:2000323	9.37	CLOCK ARNTL
14	regulation of hair cycle	GO:0042634	9.32	CLOCK ARNTL
15	regulation of type B pancreatic cell development	GO:2000074	8.96	CLOCK ARNTL
16	DNA damage checkpoint	GO:0000077	8.8	CLOCK CHEK2 ATM

Molecular functions related to Bile Duct Cystadenoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	DNA-binding transcription factor activity, RNA polymerase II-specific	GO:0000981	9.76	ESR2 ESR1 CLOCK ARNTL
2	sequence-specific DNA binding	GO:0043565	9.67	ESR2 ESR1 CLOCK ARNTL
3	RNA polymerase II proximal promoter sequence-specific DNA binding	GO:0000978	9.56	ESR2 ESR1 CLOCK ARNTL
4	steroid hormone receptor activity	GO:0003707	9.48	ESR2 ESR1
5	E-box binding	GO:0070888	9.43	CLOCK ARNTL
6	nuclear receptor activity	GO:0004879	9.4	ESR2 ESR1
7	steroid binding	GO:0005496	9.32	ESR2 ESR1
8	estrogen receptor activity	GO:0030284	9.16	ESR2 ESR1
9	estrogen response element binding	GO:0034056	8.96	ESR2 ESR1
10	repressing transcription factor binding	GO:0070491	8.8	ESR2 ESR1 ARNTL

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Sources for Bile Duct Cystadenoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia