Bile Duct Cystadenoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Bile Duct Cystadenoma

MalaCards integrated aliases for Bile Duct Cystadenoma:

Name: Bile Duct Cystadenoma ¹² ¹⁵ ⁷¹

Cystadenoma of the Bile Duct ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases Liver diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5384

NCIt ⁵⁰ C4129

SNOMED-CT ⁶⁷ 83025009

UMLS ⁷¹ C0334285

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Summaries for Bile Duct Cystadenoma

Disease Ontology : ¹² A biliary tract benign neoplasm that is located in the bile duct and derives from epithelial cells.

MalaCards based summary : Bile Duct Cystadenoma, also known as cystadenoma of the bile duct, is related to intrahepatic bile duct cystadenoma and extrahepatic bile duct cystadenoma, and has symptoms including abdominal pain and icterus. An important gene associated with Bile Duct Cystadenoma is PER3 (Period Circadian Regulator 3), and among its related pathways/superpathways are Chks in Checkpoint Regulation and Circadian rythm related genes. Affiliated tissues include bile duct, and related phenotypes are cardiovascular system and adipose tissue

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Related Diseases for Bile Duct Cystadenoma

Diseases related to Bile Duct Cystadenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)

#	Related Disease	Score	Top Affiliating Genes
1	intrahepatic bile duct cystadenoma	11.3
2	extrahepatic bile duct cystadenoma	11.3
3	cystadenoma	10.3
4	gum cancer	10.2	PER3 ARNTL
5	bipolar i disorder	10.1	PER3 ARNTL
6	congenital heart defects, hamartomas of tongue, and polysyndactyly	10.0
7	advanced sleep phase syndrome, familial, 1	10.0	PER3 CLOCK ARNTL
8	advanced sleep phase syndrome	10.0	PER3 CLOCK ARNTL
9	delayed sleep phase disorder	10.0	PER3 CLOCK ARNTL
10	sleep disorder	10.0	PER3 CLOCK ARNTL
11	nonmucinous bronchioloalveolar adenocarcinoma	10.0	ESR2 ESR1
12	postmenopausal atrophic vaginitis	10.0	ESR2 ESR1
13	vaginitis	10.0	ESR2 ESR1
14	gender identity disorder	10.0	ESR2 ESR1
15	progesterone resistance	10.0	ESR2 ESR1
16	vaginal cancer	9.9	ESR2 ESR1
17	progesterone-receptor positive breast cancer	9.9	ESR2 ESR1
18	estrogen excess	9.9	ESR2 ESR1
19	endometriosis of ovary	9.9	ESR2 ESR1
20	dental fluorosis	9.9	ESR2 ESR1
21	lobular neoplasia	9.9	ESR2 ESR1
22	thoracic benign neoplasm	9.9	ESR2 ESR1
23	breast benign neoplasm	9.9	ESR2 ESR1
24	testicular germ cell cancer	9.9	ESR2 ESR1
25	uterine benign neoplasm	9.9	ESR2 ESR1
26	cervical adenoma malignum	9.9	CHEK2 ATM
27	reproductive organ benign neoplasm	9.9	ESR2 ESR1
28	idiopathic scoliosis	9.9	ESR2 ESR1
29	aromatase excess syndrome	9.9	ESR2 ESR1
30	t-cell prolymphocytic leukemia	9.9	CHEK2 ATM
31	synchronous bilateral breast carcinoma	9.8	ESR1 ATM
32	adenomyosis	9.8	ESR2 ESR1
33	pelvic organ prolapse	9.8	ESR2 ESR1
34	teeth hard tissue disease	9.8	ESR2 ESR1
35	telangiectasis	9.8	CHEK2 ATM
36	gynecomastia	9.8	ESR2 ESR1
37	major depressive disorder	9.7	PER3 ESR1 CLOCK ARNTL
38	primary pigmented nodular adrenocortical disease	9.7	ESR2 ESR1
39	female breast cancer	9.6	ESR1 ATM
40	bilateral breast cancer	9.6	ESR1 CHEK2 ATM
41	melanoma, cutaneous malignant 1	9.6	TCHP CHEK2 ATM
42	gastric cancer, hereditary diffuse	9.5	CHEK2 ATM
43	autosomal genetic disease	9.5	ESR2 ESR1 ATM
44	autosomal recessive disease	9.5	ESR2 ESR1 ATM
45	li-fraumeni syndrome	9.3	TCHP ESR1 CHEK2 ATM
46	skin carcinoma	9.3	TCHP ESR1 CHEK2 ATM
47	sporadic breast cancer	9.3	ESR2 ESR1 CHEK2 ATM
48	leukemia, acute myeloid	9.3	TCHP ESR1 CHEK2 ATM
49	premature menopause	9.3	ESR2 ESR1 CHEK2 ATM
50	disease of mental health	8.9	PER3 ESR2 ESR1 CLOCK ATM ARNTL

Graphical network of the top 20 diseases related to Bile Duct Cystadenoma:

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Symptoms & Phenotypes for Bile Duct Cystadenoma

UMLS symptoms related to Bile Duct Cystadenoma:

abdominal pain, icterus

MGI Mouse Phenotypes related to Bile Duct Cystadenoma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	9.73	ARNTL ATM CHEK2 CLOCK ESR1 ESR2
2	adipose tissue	MP:0005375	9.72	ARNTL ATM CLOCK ESR1 ESR2
3	endocrine/exocrine gland	MP:0005379	9.63	ARNTL ATM CHEK2 CLOCK ESR1 ESR2
4	nervous system	MP:0003631	9.5	ARNTL ATM CHEK2 CLOCK ESR1 ESR2
5	reproductive system	MP:0005389	9.1	ARNTL ATM CHEK2 CLOCK ESR1 ESR2

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Drugs & Therapeutics for Bile Duct Cystadenoma

Search Clinical Trials , NIH Clinical Center for Bile Duct Cystadenoma

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Genetic Tests for Bile Duct Cystadenoma

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Anatomical Context for Bile Duct Cystadenoma

The Foundational Model of Anatomy Ontology organs/tissues related to Bile Duct Cystadenoma:

¹⁹

Bile Duct

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Publications for Bile Duct Cystadenoma

Articles related to Bile Duct Cystadenoma:

#	Title	Authors	PMID	Year
1	Definitive diagnosis of a duplicate gallbladder can only be made intraoperatively: report of a case. ⁶¹	Ozaki N...Baba H	26185884	2014
2	Adult mesenchymal hamartoma of the liver mimicking bile duct cystadenoma. ⁶¹	Yamamoto M...Matsumoto Y	7951866	1994
3	Biliary obstruction due to intraductal tumor. ⁶¹	Smith JA...Gibson RN	2548467	1989
4	[Surgically removed bile duct cystadenoma]. ⁶¹	Skaliczki J...Altorjay I	5212262	1968
5	Bile duct cystadenoma of the liver. ⁶¹	Snedecor PA	6027619	1967
6	[Benign tumor of biliary tract papillary cystadenoma of the bile duct]. ⁶¹	FERNANDEZ TASENDE DJ	13344312	1956

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Genes for Bile Duct Cystadenoma

Genes related to Bile Duct Cystadenoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PER3	Period Circadian Regulator 3	Protein Coding	5.2	DISEASES inferred ¹⁵
2	CLOCK	Clock Circadian Regulator	Protein Coding	4.95	DISEASES inferred ¹⁵
3	ARNTL	Aryl Hydrocarbon Receptor Nuclear Translocator Like	Protein Coding	4.7	DISEASES inferred ¹⁵
4	CHEK2	Checkpoint Kinase 2	Protein Coding	4.16	DISEASES inferred ¹⁵
5	TCHP	Trichoplein Keratin Filament Binding	Protein Coding	4.08	DISEASES inferred ¹⁵
6	ESR2	Estrogen Receptor 2	Protein Coding	3.94	DISEASES inferred ¹⁵
7	ATM	ATM Serine/Threonine Kinase	Protein Coding	3.7	DISEASES inferred ¹⁵
8	ESR1	Estrogen Receptor 1	Protein Coding	3.21	DISEASES inferred ¹⁵

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Variations for Bile Duct Cystadenoma

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Expression for Bile Duct Cystadenoma

Search GEO for disease gene expression data for Bile Duct Cystadenoma.

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Pathways for Bile Duct Cystadenoma

Pathways related to Bile Duct Cystadenoma according to GeneCards Suite gene sharing:

(show all 20)

#	Super pathways	Score	Top Affiliating Genes
1	Chks in Checkpoint Regulation ⁶³ Show member pathways DNA Repair Mechanisms ⁶³ Estrogen-mediated S-Phase Entry ⁶³ G2-M Phase Transition ⁶³ Parkinson's Disease Pathway ⁶³ SREBP Proteolysis ⁶³	12.16	ESR2 ESR1 CHEK2 ATM
2	Circadian rythm related genes ¹	11.97	PER3 CLOCK ARNTL
3	Integrated Breast Cancer Pathway ¹	11.77	ESR1 CHEK2 ATM
4	p53 pathway ¹	11.36	CHEK2 ATM
5	Diurnally Regulated Genes with Circadian Orthologs ¹	11.27	CLOCK ARNTL
6	Integrated Cancer Pathway ¹	11.24	CHEK2 ATM
7	ATM Signaling Network in Development and Disease ¹	11.23	CHEK2 ATM
8	Cell cycle Role of 14-3-3 proteins in cell cycle regulation ²³ Show member pathways 14-3-3 and Cell Cycle Regulation ⁶³	11.21	CHEK2 ATM
9	DNA damage_ATM/ATR regulation of G1/S checkpoint ²³	11.19	CHEK2 ATM
10	FOXM1 transcription factor network ¹	11.1	ESR1 CHEK2
11	Ovarian Infertility Genes ¹	11.03	ESR2 ATM
12	Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2 ²³	10.96	ESR2 ESR1
13	Plasma membrane estrogen receptor signaling ¹	10.91	ESR2 ESR1
14	MNAR-PELP1 and Estrogen Receptor Interaction ⁶³	10.82	ESR2 ESR1
15	Gemtuzumab ozogamicin Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	10.79	CHEK2 ATM
16	Circadian rhythm ³⁶ Show member pathways Circadian Clock in Mammals ⁶³	10.77	PER3 CLOCK ARNTL
17	Circadian rhythm pathway ¹	10.51	CLOCK ARNTL
18	Metabolic States and Circadian Oscillators ⁶³ Show member pathways lactate fermentation (reoxidation of cytosolic NADH) ¹	10.4	CLOCK ARNTL
19	Melatonin metabolism and effects ¹	10.37	PER3 CLOCK ARNTL
20	Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics ⁶⁰	9.76	ESR2 ESR1

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GO Terms for Bile Duct Cystadenoma

Cellular components related to Bile Duct Cystadenoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	chromatoid body	GO:0033391	8.62	CLOCK ARNTL

Biological processes related to Bile Duct Cystadenoma according to GeneCards Suite gene sharing:

(show all 18)

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of transcription, DNA-templated	GO:0006355	9.93	ESR2 ESR1 CLOCK CHEK2 ARNTL
2	positive regulation of transcription by RNA polymerase II	GO:0045944	9.88	ESR2 ESR1 CLOCK ATM ARNTL
3	rhythmic process	GO:0048511	9.67	PER3 CLOCK ARNTL
4	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	GO:0006977	9.58	CHEK2 ATM
5	intrinsic apoptotic signaling pathway in response to DNA damage	GO:0008630	9.57	CHEK2 ATM
6	cellular response to estradiol stimulus	GO:0071392	9.56	ESR2 ESR1
7	cellular response to gamma radiation	GO:0071480	9.55	CHEK2 ATM
8	positive regulation of transcription, DNA-templated	GO:0045893	9.55	ESR2 ESR1 CLOCK CHEK2 ARNTL
9	intracellular estrogen receptor signaling pathway	GO:0030520	9.52	ESR2 ESR1
10	replicative senescence	GO:0090399	9.51	CHEK2 ATM
11	response to redox state	GO:0051775	9.46	CLOCK ARNTL
12	intracellular steroid hormone receptor signaling pathway	GO:0030518	9.43	ESR2 ESR1
13	circadian regulation of gene expression	GO:0032922	9.43	PER3 CLOCK ARNTL
14	DNA damage induced protein phosphorylation	GO:0006975	9.4	CHEK2 ATM
15	negative regulation of glucocorticoid receptor signaling pathway	GO:2000323	9.37	CLOCK ARNTL
16	regulation of hair cycle	GO:0042634	9.32	CLOCK ARNTL
17	regulation of type B pancreatic cell development	GO:2000074	8.96	CLOCK ARNTL
18	DNA damage checkpoint	GO:0000077	8.8	CLOCK CHEK2 ATM

Molecular functions related to Bile Duct Cystadenoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	DNA-binding transcription factor activity	GO:0003700	9.62	ESR2 ESR1 CLOCK ARNTL
2	sequence-specific DNA binding	GO:0043565	9.46	ESR2 ESR1 CLOCK ARNTL
3	nuclear receptor activity	GO:0004879	9.43	ESR2 ESR1
4	E-box binding	GO:0070888	9.4	CLOCK ARNTL
5	steroid binding	GO:0005496	9.37	ESR2 ESR1
6	steroid hormone receptor activity	GO:0003707	9.26	ESR2 ESR1
7	estrogen receptor activity	GO:0030284	8.96	ESR2 ESR1
8	estrogen response element binding	GO:0034056	8.62	ESR2 ESR1

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Sources for Bile Duct Cystadenoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia