Bile Duct Disease

Categories: Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Bile Duct Disease

MalaCards integrated aliases for Bile Duct Disease:

Name: Bile Duct Disease 12 15
Bile Duct Diseases 42 44 70
Disorder of Bile Duct 12
Bile Duct Disorder 12


External Ids:

Disease Ontology 12 DOID:4138
MeSH 44 D001649
NCIt 50 C96716
SNOMED-CT 67 118926004
UMLS 70 C0005395

Summaries for Bile Duct Disease

MedlinePlus : 42 Your liver makes a digestive juice called bile. Your gallbladder stores it between meals. When you eat, your gallbladder pushes the bile into tubes called bile ducts. They carry the bile to your small intestine. The bile helps break down fat. It also helps the liver get rid of toxins and wastes. Different diseases can block the bile ducts and cause a problem with the flow of bile: Gallstones, which can increase pressure in the gallbladder and cause a gallbladder attack. The pain usually lasts from one to several hours. Cancer Infections Birth defects, such as biliary atresia. It is the most common reason for liver transplants in children in the United States. Inflammation, which can cause scarring. Over time, this can lead to liver failure. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Bile Duct Disease, also known as bile duct diseases, is related to common bile duct disease and cholangitis, and has symptoms including nausea and vomiting, constipation and abdominal pain. An important gene associated with Bile Duct Disease is GPT (Glutamic--Pyruvic Transaminase), and among its related pathways/superpathways are MicroRNAs in cancer and Bile secretion. The drugs Scopolamine and Fentanyl have been mentioned in the context of this disorder. Affiliated tissues include liver, small intestine and pancreas.

Wikipedia : 73 A bile duct is any of a number of long tube-like structures that carry bile, and is present in most... more...

Related Diseases for Bile Duct Disease

Diseases in the Bile Duct Disease family:

Common Bile Duct Disease

Diseases related to Bile Duct Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 332)
# Related Disease Score Top Affiliating Genes
1 common bile duct disease 32.9 MIR222 GPT ALB ABCB4 ABCB11
2 cholangitis 32.5 NR1H4 MIR222 GPT ALB ABCB4 ABCB11
3 cholestasis 32.4 NR1H4 GPT ATP8B1 ALB ABCB4 ABCB11
4 sclerosing cholangitis 31.1 NR1H4 MIR222 GPT ALB ABCB4 ABCB11
5 cholangitis, primary sclerosing 31.0 NR1H4 MIR222 MIR199A1 GPT CCR6 ALB
6 bile duct cancer 30.9 MIR9-1 MIR199A1 MIR17 MIR145 KDM4C H2AC18
7 choledocholithiasis 30.7 GPT ALB ABCB4
8 cholelithiasis 30.7 NR1H4 GPT ALB ABCB4
9 bile duct cysts 30.7 GPT ATP8B1 ALB ABCB4 ABCB11
10 cholecystitis 30.7 GPT ALB ABCB4
11 bilirubin metabolic disorder 30.6 NR1H4 GPT ATP8B1 ALB ABCB4 ABCB11
12 biliary atresia 30.6 NR1H4 GPT ATP8B1 ALB ABCB4 ABCB11
13 non-alcoholic fatty liver disease 30.6 NR1H4 MIR199A1 MIR17 MIR140 GPT ALB
14 hemochromatosis, type 1 30.5 MIR199A1 H2AC18 GPT ALB
15 primary biliary cholangitis 30.5 NR1H4 MIR483 MIR17 MIR150 H2AC18 GPT
16 biliary tract disease 30.4 SERPINA3 NR1H4 MIR9-1 MIR483 MIR29A MIR222
17 cholecystolithiasis 30.1 GPT ABCB4
18 caroli disease 11.1
19 dipetalonemiasis 10.6 GPT ALB
20 atp8b1 deficiency 10.6 NR1H4 ATP8B1 ABCB11
21 parenteral nutrition-associated cholestasis 10.6 GPT ABCB4
22 extrahepatic cholestasis 10.6 NR1H4 GPT ABCB4 ABCB11
23 splenic infarction 10.6 SERPINA3 GPT ALB
24 central nervous system hematologic cancer 10.6 MIR199A1 KDM4C CCR6
25 heterophyiasis 10.6 GPT ALB
26 progressive relapsing multiple sclerosis 10.6 SERPINA3 H2AC18 CCR6
27 afferent loop syndrome 10.6 GPT ALB
28 bronchopneumonia 10.6 SERPINA3 GPT ALB
29 esophagus adenocarcinoma 10.6 MIR199A1 MIR196A1 MIR145
30 cecal disease 10.6 SERPINA3 GPT CCR6 ALB
31 intestinal perforation 10.6 SERPINA3 GPT ALB
32 cellulitis 10.6 GPT CCR6 ALB
33 pyelitis 10.6 SERPINA3 CCR6 ALB
34 ampulla of vater adenocarcinoma 10.6 MIR222 MIR196A1 MIR145
35 aspiration pneumonia 10.6 SERPINA3 GPT ALB
36 cholestasis, progressive familial intrahepatic, 5 10.6 NR1H4 ATP8B1 ABCB4 ABCB11
37 cerebral arterial disease 10.6 SERPINA3 MIR199A1 MIR145
38 cholestasis, progressive familial intrahepatic, 4 10.6 NR1H4 ATP8B1 ABCB4 ABCB11
39 conjunctival disease 10.6 GPT CCR6 ALB
40 hypersensitivity reaction type iii disease 10.6 SERPINA3 CCR6 ALB
41 plasma protein metabolism disease 10.6 SERPINA3 GPT CCR6 ALB
42 cholestasis, benign recurrent intrahepatic, 2 10.6 NR1H4 ATP8B1 ABCB4 ABCB11
43 ovarian serous carcinoma 10.6 MIR29A MIR199A1 MIR145
44 autoimmune disease of urogenital tract 10.6 H2AC18 CCR6 ALB
45 klebsiella pneumonia 10.6 H2AC18 CCR6 ALB
46 syphilis 10.6 SERPINA3 GPT CCR6 ALB
47 familial intrahepatic cholestasis 10.6 NR1H4 ATP8B1 ABCB4 ABCB11
48 vein disease 10.6 SERPINA3 GPT CCR6 ALB
49 pulmonary artery disease 10.6 SERPINA3 GPT ALB
50 ureteral disease 10.6 MIR199A1 CCR6 ALB

Graphical network of the top 20 diseases related to Bile Duct Disease:

Diseases related to Bile Duct Disease

Symptoms & Phenotypes for Bile Duct Disease

UMLS symptoms related to Bile Duct Disease:

nausea and vomiting; constipation; abdominal pain; diarrhea; dyspepsia; icterus; heartburn; gastrointestinal gas

Drugs & Therapeutics for Bile Duct Disease

Drugs for Bile Duct Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 53)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Scopolamine Approved, Investigational Phase 3 51-34-3, 6533-68-2 5184
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
Hydromorphone Approved, Illicit Phase 3 466-99-9 5284570
Bupivacaine Approved, Investigational Phase 3 2180-92-9, 38396-39-3 2474
Diclofenac Approved, Vet_approved Phase 2, Phase 3 15307-86-5 3033
6 Parasympatholytics Phase 3
7 Bromides Phase 3
8 Gastrointestinal Agents Phase 3
9 Neurotransmitter Agents Phase 3
10 Vasodilator Agents Phase 3
11 Antiemetics Phase 3
12 Cholinergic Agents Phase 3
13 Mydriatics Phase 3
14 Drotaverin Phase 3
15 Muscarinic Antagonists Phase 3
16 Butylscopolammonium Bromide Phase 3
17 Cholinergic Antagonists Phase 3
18 Liver Extracts Phase 3
19 Anesthetics Phase 3
20 Tea Phase 3
21 Narcotics Phase 3
22 Analgesics, Opioid Phase 3
23 Anesthetics, Local Phase 3
24 Anesthetics, Intravenous Phase 3
25 Anesthetics, General Phase 3
26 Analgesics, Non-Narcotic Phase 2, Phase 3
27 Analgesics Phase 2, Phase 3
28 Cyclooxygenase Inhibitors Phase 2, Phase 3
29 Antirheumatic Agents Phase 2, Phase 3
30 Anti-Inflammatory Agents Phase 2, Phase 3
31 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
32 Pinaverium Approved 59995-65-2
Pancrelipase Approved, Investigational 53608-75-6
Iron Approved 7439-89-6 23925 29936
Pentetic acid Approved 67-43-6
Edetic Acid Approved, Vet_approved 62-33-9, 60-00-4 6049
Vitamin C Approved, Nutraceutical 50-81-7 5785 54670067
38 Nutrients
39 Trace Elements
40 Vitamins
41 Micronutrients
42 Anticonvulsants
43 Antioxidants
44 Hormones
45 calcium channel blockers
46 pancreatin
47 Protective Agents
48 Calcium, Dietary
49 Antidotes
50 Chelating Agents

Interventional clinical trials:

(show all 33)
# Name Status NCT ID Phase Drugs
1 Pilot Study on the Usefulness of Endoscopic Ultrasound-guided Biliary Drainage With a Newly Designed Hybrid Metallic Stent Completed NCT01862198 Phase 4
2 The Efficacy and Safety of Precut Papillotomy Using the Knob-tipped Knife and Needle Knife in Difficult Biliary Cannulation: a Randomized-controlled Trial. Unknown status NCT01745978 Phase 3
3 Digital SpyGlass Cholangioscopy Confirmed Common Bile Duct Stones Clearance Without Fluoroscopy Completed NCT02967926 Phase 3
4 Newly Designed Fully Covered Metal Stent for the Benign Biliary Stricture: Prospective Randomized Study Completed NCT00945516 Phase 3
5 Drotaverine Hydrochloride Versus Hyoscine-N-butylbromide for Duodenal Antimotility During ERCP: a Prospective, Multicenter Randomized Controlled Trial Completed NCT00731198 Phase 3 Drotaverine hydrochloride;Hyoscine-N-butylbromide
6 Randomized, Unblinded, Phase III Trial of Thoracic Epidural Analgesia Versus Four-Quadrant Transversus Abdominus Plane Block in Oncologic Open-Incision Liver Surgery Recruiting NCT03214510 Phase 3 Bupivacaine;Fentanyl;Hydromorphone Hydrochloride;Liposomal Bupivacaine
7 Diclofenac for Prevention of Post-ERC Pancreatitis Not yet recruiting NCT03595150 Phase 2, Phase 3 Diclofenac
8 A Double Blind, Randomized Controlled Prospective Trial of Endo-biliary Radio-frequency Ablation for Maintenance of Metal Stent Patency in Patients With Malignant Obstructive Jaundice Unknown status NCT01275768 Phase 1, Phase 2
9 Safety and Efficacy Study of IL-10 (Tenovil TM) in the Prevention of Post-ERCP Acute Pancreatitis (Study P02580)(TERMINATED) Terminated NCT00040131 Phase 2 IL-10
10 A Phase 2, Randomized, Double-Blind Study of HTD1801 vs Ursodeoxycholic Acid (UDCA) in Adolescents With Primary Sclerosing Cholangitis (PSC) Withdrawn NCT03678480 Phase 2 HTD1801;Ursodeoxycholic Acid
11 Double Guide Wire Placement Compared With Conventional Method in Cases of Difficult Common Bile Duct Cannulation in Endoscopic Retrograde Cholangiopancreatography Procedures. A Controlled Multicentred Randomized Trial. Unknown status NCT00270868
12 Impact of Pinaverium Bromide on Bile Duct and Pancreatic Duct Cannulation During Endoscopic Retrograde Cholangiopancreatography Unknown status NCT02882451
13 Assessment of Cholangio-pancreatoscopy for the Diagnosis and the Treatment of Biliary and Pancreatic Diseases Trial " EASYSPY " Unknown status NCT03190343
14 Comparison of Iatrogenic Common Bile Duct Injuries Following Open Cholecystectomy vs Laparoscopic Cholecystectomy Unknown status NCT00840138
15 Endoscopic Retrograde Cholangiopancreatography, Endoscopic Ultrasound and Interventional Endoscopy in Pancreatico-biliary, Gastrointestinal and Esophageal Disorders Unknown status NCT01438385
16 Comparison of Multibending and Conventional Ultra-slim Upper Endoscope for the Direct Advance Into the Bile Duct Without Assisting Accessory in Peroral Cholangioscopy Unknown status NCT02189421
17 Intra-ductal Confocal Endomicroscopy for Characterization of Pancreas and Bile Duct Tumor Completed NCT00930410
18 Safety and Efficacy of a New Baby-sphincterotome for Cannulation and Pre-cut in Failed Selective Wire-guided Bile Duct Access Completed NCT01493076
19 Is the Gastro LMA a Feasible Alternative to the Use of a Native Airway for Endoscopic Retrograde Cholangiopancreatography (ERCP) Cases? Completed NCT03775681
20 Are Fully Covered Metal Stents Superior to Plastic Stents for Preoperative Biliary Decompression in Malignant Distal Bile Duct Obstruction? Completed NCT01789502
21 Retrospective Study About Primary Biliary Cholangitis During January 2001 to July 2016 at West China Hospital Completed NCT02917408
22 Evaluation of Outcomes From Treatment of Benign or Malignant Liver and Bile Duct Diseases Recruiting NCT04637243
23 Clinical Efficacy and Infection Risk of ERCP Using a Novel Duodenoscope With a Disposable Cap: a Randomized Controlled Trial Recruiting NCT04040504
24 A Feasibility Study of Electronic Neurocognitive Screening Tools in Surgery Recruiting NCT03678441
25 Radiologic Detection and Characterization of Benign and Malignant Liver Lesions in Contrast-Enhanced MRI Recruiting NCT02156739 Gadobutrol;Gadoxetate Disodium
26 Results of the Surgical Treatment of Patients From Hepatobiliopancreatic Surgical Unit at the Complejo Hospitalario de Navarra Recruiting NCT04556019
27 CO2 Cholangiography as an Alternative to Iodinated Contrast in Endoscopic Retrograde Cholangiopancreatography Recruiting NCT02611453
28 Registry to Evaluate the Outcomes Following Algorithmic Approach in the Endoscopic Treatment of Bile Duct Stones Recruiting NCT04145843
29 Trainee Involvement in ERCP Risk Score Active, not recruiting NCT04341909
30 Volumetric Laser Endomicroscopy's (VLE) Diagnostic Accuracy Validation Study: Impact on Clinical Management Study Enrolling by invitation NCT03951324
31 Double Guidewire Technique Versus Transpancreatic Precut in Patients With Repetitive Unintentional Cannulation of the Pancreatic Duct. Not yet recruiting NCT04503200
32 Flexible Percutaneous Transhepatic Cholangiopancreatoscopy (PTCS) in Complex Pancreaticobiliary Disease Not yet recruiting NCT04580940
33 Early Precut Sphincterotomy During ERCP With Difficult Biliary Access (Italian: Esecuzione Del Pre-cut Precoce in Corso di ERCP Con Difficoltosa Incannulazione Della Via Biliare) Terminated NCT02596646

Search NIH Clinical Center for Bile Duct Disease

Cochrane evidence based reviews: bile duct diseases

Genetic Tests for Bile Duct Disease

Anatomical Context for Bile Duct Disease

MalaCards organs/tissues related to Bile Duct Disease:

Liver, Small Intestine, Pancreas, T Cells, Fetal Liver

Publications for Bile Duct Disease

Articles related to Bile Duct Disease:

(show top 50) (show all 329)
# Title Authors PMID Year
Endoscopic stent placement above the sphincter of Oddi for biliary strictures after living donor liver transplantation. 42
32252630 2020
Radiation exposure during endoscopic retrograde cholangiopancreatography according to clinical determinants. 42
32221072 2020
A practical new strategy to prevent bile duct injury during laparoscopic cholecystectomy. A single-center experience with 5539 cases. 42
32667588 2020
Exome sequencing in patient-parent trios suggests new candidate genes for early-onset primary sclerosing cholangitis. 61
33590606 2021
Deletion of interleukin enhancer binding factor 2 (ILF2) resulted in defective biliary development and bile flow blockage. 61
32709532 2021
Clinical Management of Bile Duct Diseases: Role of Endoscopic Ultrasound in a Personalized Approach. 61
33374902 2020
Beta-amyloid deposition around hepatic bile ducts is a novel pathobiological and diagnostic feature of biliary atresia. 61
32553668 2020
Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease. 61
33318612 2020
Conservative Management of Gallstone Disease in the Elderly Population: Outcomes and Recurrence. 61
30791835 2020
Machine Learning Model Comparison in the Screening of Cholangiocarcinoma Using Plasma Bile Acids Profiles. 61
32748848 2020
Opisthorchis felineus infection, risks, and morbidity in rural Western Siberia, Russian Federation. 61
32598389 2020
Robotic Biliary Surgery. 61
32169181 2020
Cholangiocarcinoma in patients with primary sclerosing cholangitis. 61
31850928 2020
Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors. 61
31974352 2020
[Treatment of severe post-resection liver failure. Analysis of the specialized center]. 61
33301260 2020
The diagnostic and prognostic value of UBE2T in intrahepatic cholangiocarcinoma. 61
32025379 2020
33148834 2020
Return to sender: Lymphocyte trafficking mechanisms as contributors to primary sclerosing cholangitis. 61
31108158 2019
The role of imaging in determining prognosis for primary sclerosing cholangitis: A systematic review. 61
31044745 2019
Th17 cell frequency is associated with low bone mass in primary sclerosing cholangitis. 61
30641095 2019
[Biliary system : What does the surgeon want to know from the radiologist?] 61
30820620 2019
[Diseases and diagnosis of the biliary system : When does the gastroenterologist need the radiologist?] 61
30806734 2019
[Differential diagnoses of biliary tract diseases : Computed tomography and magnetic resonance imaging]. 61
30820619 2019
Comparison of digital versus fiberoptic cholangioscopy in patients requiring evaluation of bile duct disease or treatment of biliary stones. 61
30837794 2019
Recombinant adenylate kinase 3 from liver fluke Clonorchis sinensis for histochemical analysis and serodiagnosis of clonorchiasis. 61
29580315 2018
30516496 2018
Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis. 61
28779025 2018
Small molecule metabolite biomarkers for hepatocellular carcinoma with bile duct tumor thrombus diagnosis. 61
29459779 2018
Interleukin-6 promotes the migration and cellular senescence and inhibits apoptosis of human intrahepatic biliary epithelial cells. 61
28857276 2018
[Clinical and laboratory features of cholelithiasis in patients with type 2 diabetes by gender]. 61
29783219 2018
Gallbladder and bile duct disease in Cystic Fibrosis. 61
28986023 2017
Clinical Feasibility of 3-Dimensional Magnetic Resonance Cholangiopancreatography Using Compressed Sensing: Comparison of Image Quality and Diagnostic Performance. 61
28448309 2017
norUrsodeoxycholic acid improves cholestasis in primary sclerosing cholangitis. 61
28529147 2017
A disposition kinetic study of Tramadol in bile duct ligated rats in perfused rat liver model. 61
28460228 2017
Adhesive Capsulitis of the Shoulder: Evaluation With US-Arthrography Using a Sonographic Contrast Agent. 61
28717193 2017
Surveillance of primary sclerosing cholangitis with ERC and brush cytology: risk factors for cholangiocarcinoma. 61
27806633 2017
Anti-GP2 IgA autoantibodies are associated with poor survival and cholangiocarcinoma in primary sclerosing cholangitis. 61
27406039 2017
Pediatric cholangiopathies: diseases of the gallbladder and biliary tract. 61
27518785 2017
Effect of miR-29c and miR-129-5p on epithelial-mesenchymal transition in experimental biliary atresia mouse models. 61
27706677 2016
Early precut sphincterotomy for difficult biliary access to reduce post-ERCP pancreatitis: a randomized trial. 61
26990509 2016
Cholangiocytes derived from induced pluripotent stem cells for disease modeling. 61
27054776 2016
Sclerosing Cholangitis in Children and Adolescents. 61
26593293 2016
Assessment of Pharmacological Prophylaxis for Acute Pancreatitis Following ERCP in Patients with Choledoholithiasis. 61
26963056 2015
The diagnostic and prognostic value of MRP8/MRP14 in intrahepatic cholangiocarcinoma. 61
26472105 2015
Burden of Gastrointestinal and Liver Diseases in Iran: Estimates Based on the Global Burden of Disease, Injuries, and Risk Factors Study, 2010. 61
26396716 2015
Multidisciplinary Treatment of Cystic Fibrosis-Related Recurrent Pyogenic Cholangitis (CF-RPC). 61
25630419 2015
Human pluripotent stem cell-derived cholangiocytes: current status and future applications. 61
25850348 2015
Surgically avertable burden of digestive diseases at first-level hospitals in low and middle-income regions. 61
25444219 2015
Effect of p38 mitogen-activate protein kinase on MUC5AC protein expression of bile duct epithelial cells in hepatolithiasis patients. 61
26722604 2015
Severe acute hepatitis in a printing company worker: a case study. 61
25410269 2015

Variations for Bile Duct Disease

Expression for Bile Duct Disease

Search GEO for disease gene expression data for Bile Duct Disease.

Pathways for Bile Duct Disease

GO Terms for Bile Duct Disease

Cellular components related to Bile Duct Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 ALB GPT MIR140 MIR150 MIR17 MIR199A1
2 extracellular exosome GO:0070062 9.32 SERPINA3 MIR9-1 MIR29A MIR17 MIR145 H2AC18
3 intercellular canaliculus GO:0046581 9.16 ABCB4 ABCB11

Biological processes related to Bile Duct Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 9.58 MIR483 MIR199A1 MIR196A1
2 bile acid and bile salt transport GO:0015721 9.5 ABCB11 ATP8B1 NR1H4
3 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.46 MIR199A1 MIR17
4 drug transmembrane transport GO:0006855 9.43 ATP8B1 ABCB11
5 negative regulation of vascular endothelial growth factor production GO:1904046 9.43 MIR140 MIR17 MIR199A1
6 miRNA mediated inhibition of translation GO:0035278 9.43 MIR145 MIR17 MIR222 MIR29A MIR483 MIR9-1
7 cellular response to bile acid GO:1903413 9.37 NR1H4 ABCB4
8 bile acid metabolic process GO:0008206 9.33 ABCB11 ATP8B1 NR1H4
9 gene silencing by miRNA GO:0035195 9.32 MIR140 MIR145 MIR150 MIR17 MIR196A1 MIR199A1

Molecular functions related to Bile Duct Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA 3'-UTR binding GO:0003730 9.35 MIR9-1 MIR29A MIR17 MIR145 MIR140
2 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.32 MIR140 MIR145 MIR150 MIR17 MIR196A1 MIR199A1

Sources for Bile Duct Disease

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
69 Tocris
71 UMLS via Orphanet
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