Bile Duct Mucinous Adenocarcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Bile Duct Mucinous Adenocarcinoma

MalaCards integrated aliases for Bile Duct Mucinous Adenocarcinoma:

Name: Bile Duct Mucinous Adenocarcinoma ¹¹ ¹⁴

Extrahepatic Bile Duct Mucinous Adenocarcinoma ⁷¹

Mucinous Carcinoma of the Bile Duct ¹¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases Liver diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:3698

NCIt ⁴⁹ C5846

UMLS ⁷¹ C0861856

Sources

Summaries for Bile Duct Mucinous Adenocarcinoma

MalaCards based summary: Bile Duct Mucinous Adenocarcinoma, also known as extrahepatic bile duct mucinous adenocarcinoma, is related to urinary bladder villous adenoma and mucinous intrahepatic cholangiocarcinoma, and has symptoms including vomiting, abdominal pain and pruritus. An important gene associated with Bile Duct Mucinous Adenocarcinoma is MUC1 (Mucin 1, Cell Surface Associated), and among its related pathways/superpathways are Diseases of glycosylation and CLEC7A (Dectin-1) signaling.

Sources

Related Diseases for Bile Duct Mucinous Adenocarcinoma

Diseases related to Bile Duct Mucinous Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 284)

#	Related Disease	Score	Top Affiliating Genes
1	urinary bladder villous adenoma	10.2	MUC5AC MUC1
2	mucinous intrahepatic cholangiocarcinoma	10.2	MUC5AC MUC1
3	pancreatic mucinous cystadenoma	10.2	MUC5AC MUC1
4	acute cholangitis	10.2	MUC5AC MUC1
5	solid adenocarcinoma with mucin production	10.2	MUC5AC MUC1
6	papillary carcinoma	10.2
7	pancreatic intraductal papillary-colloid carcinoma	10.2
8	lynch syndrome 8	10.2	MUC5AC MUC1
9	bird fancier's lung	10.2	MUC5B MUC1
10	colloid carcinoma of the pancreas	10.2	MUC5B MUC5AC
11	interstitial pneumonitis, desquamative, familial	10.2	MUC5B MUC1
12	paget disease, extramammary	10.2	MUC5AC MUC1
13	acute interstitial pneumonia	10.2	MUC5B MUC1
14	vulvar eccrine porocarcinoma	10.2	SYP MUC1
15	ampulla of vater adenocarcinoma	10.1	MUC5AC MUC1
16	lung mucoepidermoid carcinoma	10.1	MUC5B MUC5AC
17	gallbladder signet ring cell adenocarcinoma	10.1	MUC4 MUC1
18	chronic purulent otitis media	10.1	MUC5B MUC5AC
19	mucinous tubular and spindle renal cell carcinoma	10.1	MUC4 MUC1
20	clear cell ependymoma	10.1	SYP MUC1
21	nonspecific interstitial pneumonia	10.1	MUC5B MUC1
22	acinar cell cystadenocarcinoma	10.1	SYP MUC5AC
23	suppurative otitis media	10.1	MUC5B MUC5AC
24	filamentary keratitis	10.1	MUC5AC MUC4
25	pancreatic foamy gland adenocarcinoma	10.1	TP53 MUC1
26	adenomyoma	10.1	MUC4 MUC1
27	idiopathic interstitial pneumonia	10.1	MUC5B MUC1
28	acute asthma	10.1	MUC5B MUC5AC
29	anaplastic ependymoma	10.1	SYP MUC1
30	myxopapillary ependymoma	10.1	SYP MUC1
31	cellular ependymoma	10.1	SYP MUC1
32	villous adenoma	10.1	TP53 MUC5AC
33	glandular cystitis	10.1	TP53 MUC1
34	asbestosis	10.1	MUC5B MUC1
35	bile duct adenoma	10.1	TP53 MUC1
36	blepharitis	10.1	MUC5AC MUC4
37	small intestine adenocarcinoma	10.1	TP53 MUC5AC
38	ovarian benign neoplasm	10.1	TP53 MUC1
39	middle ear disease	10.1	MUC5B MUC5AC
40	adenofibroma	10.0	TP53 MUC1
41	thymic carcinoma	10.0	SYP MUC1
42	lacrimal apparatus disease	10.0	MUC5AC MUC4
43	leydig cell tumor	10.0	TP53 SYP
44	thoracic benign neoplasm	10.0	TP53 MUC1
45	breast benign neoplasm	10.0	TP53 MUC1
46	breast lobular carcinoma	10.0	TP53 MUC1
47	intrahepatic cholangiocarcinoma	10.0	TP53 MUC4
48	desmoplastic nodular medulloblastoma	10.0	TP53 SYP
49	appendix adenocarcinoma	10.0	TP53 SYP
50	papillary adenoma	10.0	TP53 SYP

Graphical network of the top 20 diseases related to Bile Duct Mucinous Adenocarcinoma:

Sources

Symptoms & Phenotypes for Bile Duct Mucinous Adenocarcinoma

UMLS symptoms related to Bile Duct Mucinous Adenocarcinoma:

vomiting; abdominal pain; pruritus; nausea; icterus; malaise

Sources

Drugs & Therapeutics for Bile Duct Mucinous Adenocarcinoma

Search Clinical Trials, NIH Clinical Center for Bile Duct Mucinous Adenocarcinoma

Sources

Genetic Tests for Bile Duct Mucinous Adenocarcinoma

Sources

Anatomical Context for Bile Duct Mucinous Adenocarcinoma

Sources

Publications for Bile Duct Mucinous Adenocarcinoma

Articles related to Bile Duct Mucinous Adenocarcinoma:

#	Title	Authors	PMID	Year
1	A huge intraductal papillary mucinous carcinoma of the bile duct treated by right trisectionectomy with caudate lobectomy. ⁶²	Sohn WJ...Jo S	19961613	2009

Sources

Genes for Bile Duct Mucinous Adenocarcinoma

Genes related to Bile Duct Mucinous Adenocarcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MUC1	Mucin 1, Cell Surface Associated	Protein Coding	5.57	DISEASES inferred ¹⁴
2	MUC5AC	Mucin 5AC, Oligomeric Mucus/Gel-Forming	Protein Coding	4.5	DISEASES inferred ¹⁴
3	MUC5B	Mucin 5B, Oligomeric Mucus/Gel-Forming	Protein Coding	3.99	DISEASES inferred ¹⁴
4	MUC4	Mucin 4, Cell Surface Associated	Protein Coding	3.93	DISEASES inferred ¹⁴
5	TP53	Tumor Protein P53	Protein Coding	3.17	DISEASES inferred ¹⁴
6	ENO2	Enolase 2	Protein Coding	3.17	DISEASES inferred ¹⁴
7	SYP	Synaptophysin	Protein Coding	3.09	DISEASES inferred ¹⁴

Sources

Variations for Bile Duct Mucinous Adenocarcinoma

Sources

Expression for Bile Duct Mucinous Adenocarcinoma

Search GEO for disease gene expression data for Bile Duct Mucinous Adenocarcinoma.

Sources

Pathways for Bile Duct Mucinous Adenocarcinoma

Pathways related to Bile Duct Mucinous Adenocarcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Diseases of glycosylation ⁶⁶ Show member pathways Defective ALG1 causes CDG-1k ⁶⁶ Defective ALG11 causes CDG-1p ⁶⁶ Defective ALG12 causes CDG-1g ⁶⁶ Defective ALG14 causes ALG14-CMS ⁶⁶ Defective ALG2 causes CDG-1i ⁶⁶ Defective ALG3 causes CDG-1d ⁶⁶ Defective ALG6 causes CDG-1c ⁶⁶ Defective ALG8 causes CDG-1h ⁶⁶ Defective ALG9 causes CDG-1l ⁶⁶ Defective DPAGT1 causes CDG-1j, CMSTA2 ⁶⁶ Defective GNE causes sialuria, NK and IBM2 ⁶⁶ Defective MPDU1 causes CDG-1f ⁶⁶ Defective NEU1 causes sialidosis ⁶⁶ Defective RFT1 causes CDG-1n ⁶⁶ Diseases associated with glycosylation precursor biosynthesis ⁶⁶ Diseases associated with N-glycosylation of proteins ⁶⁶ Diseases of metabolism ⁶⁶ MPS IV - Morquio syndrome B ⁶⁶	12.27	MUC5B MUC5AC MUC4 MUC1
2	CLEC7A (Dectin-1) signaling ⁶⁶ Show member pathways Alternative NF-kappaB pathway ⁶¹ CLEC7A/inflammasome pathway ⁶⁶ C-type lectin receptors (CLRs) ⁶⁶	11.96	MUC5B MUC5AC MUC4 MUC1
3	O-linked glycosylation of mucins ⁶⁶ Show member pathways Defective C1GALT1C1 causes TNPS ⁶⁶ Defective GALNT12 causes CRCS1 ⁶⁶ Defective GALNT3 causes HFTC ⁶⁶ mucin core 1 and core 2 O-glycosylation ⁶¹ mucin core 3 and core 4 O-glycosylation ⁶¹ O-linked glycosylation ⁶⁶	11.83	MUC5B MUC5AC MUC4 MUC1
4	Diseases associated with O-glycosylation of proteins ⁶⁶ Show member pathways Defective B3GALTL causes PpS ⁶⁶ Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 ⁶⁶ O-glycosylation of TSR domain-containing proteins ⁶⁶	11.42	MUC5B MUC5AC MUC4 MUC1
5	Termination of O-glycan biosynthesis ⁶⁶ Show member pathways Dectin-2 family ⁶⁶ Maturation of protein 3a ⁶⁶ Maturation of protein 3a ⁶⁶	10.76	MUC5B MUC5AC MUC4 MUC1

Sources

GO Terms for Bile Duct Mucinous Adenocarcinoma

Cellular components related to Bile Duct Mucinous Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	Golgi lumen	GO:0005796	9.23	MUC5B MUC5AC MUC4 MUC1

Biological processes related to Bile Duct Mucinous Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	GO:0006977	9.46	TP53 MUC1
2	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO:0006978	9.26	TP53 MUC1
3	positive regulation of transcription from RNA polymerase II promoter in response to stress	GO:0036003	8.92	TP53 MUC1

Sources

Sources for Bile Duct Mucinous Adenocarcinoma

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: BLD002 MIFTS: 22	Bile Duct Mucinous Adenocarcinoma Categories: Cancer diseases, Gastrointestinal diseases, Liver diseases	Data Licensing For inquiries, contact: [email protected]
Genes Related diseases Publications Symptoms & Phenotypes Expand all tables