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MCID: BLR002
MIFTS: 38

Bile Reflux

Categories: Gastrointestinal diseases, Liver diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Bile Reflux

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MalaCards integrated aliases for Bile Reflux:

Name: Bile Reflux 12 54 44 15 17 70

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases Liver diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:12237
MeSH 44 D001655
UMLS 70 C0005403
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Summaries for Bile Reflux

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MalaCards based summary : Bile Reflux is related to gastric ulcer and gastritis. An important gene associated with Bile Reflux is CCK (Cholecystokinin), and among its related pathways/superpathways are Salivary secretion and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Cimetidine and Ranitidine have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and colon, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

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Related Diseases for Bile Reflux

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Diseases related to Bile Reflux via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 236)
# Related Disease Score Top Affiliating Genes
1 gastric ulcer 30.5 TFF1 S100A8 PTGS2 GAST
2 gastritis 30.3 SCT S100A8 PTGS2 GAST CDX2 ATP4A
3 laryngitis 30.3 ATP4A ATP12A
4 duodenogastric reflux 30.2 SCT MLN GAST CCK ATP4A ATP12A
5 gastrointestinal ulceration, recurrent, with dysfunctional platelets 30.2 S100A8 PTGS2 GAST
6 atrophic gastritis 30.0 S100A8 PTGS2 GAST CDX2
7 postcholecystectomy syndrome 29.9 MLN GAST CCK
8 postgastrectomy syndrome 29.9 MLN GAST ATP12A
9 cholangitis 29.8 NR1H4 GPBAR1 ALB
10 duodenal ulcer 29.8 SCT S100A8 MLN GAST CCK
11 biliary dyskinesia 29.7 SCT CCK ATP4A ATP12A
12 dumping syndrome 29.7 SCT MLN GAST CCK
13 pernicious anemia 29.7 SCT GAST ATP4A ATP12A
14 gastroesophageal reflux 29.6 S100A8 PTGS2 MLN GAST CDX2 CCK
15 gastroparesis 29.4 SCT MLN GAST CCK
16 peptic esophagitis 29.2 S100A8 PTGS2 MLN GAST CDX2 ATP4A
17 cholecystitis 29.1 S100A8 MUC5AC CCK ALB
18 microinvasive gastric cancer 29.1 S100A8 MUC5AC GAST CDX2 ATP4A ATP12A
19 peptic ulcer disease 29.1 SCT S100A8 PTGS2 MUC5AC GAST ATP4A
20 barrett esophagus 28.7 TFF1 S100A8 PTGS2 NR1H4 MUC5AC GAST
21 pancreatic cancer 28.1 TFF1 SCT PTGS2 MUC5AC GAST CDX2
22 esophagitis 10.5
23 vagus nerve disease 10.4 ATP4A ATP12A
24 necrotizing gastritis 10.4 ATP4A ATP12A
25 scalp dermatosis 10.4 ATP4A ATP12A
26 hemangioma of intra-abdominal structure 10.4 ATP4A ATP12A
27 acquired gastric outlet stenosis 10.4 ATP4A ATP12A
28 lingual goiter 10.4 ATP4A ATP12A
29 bacterial esophagitis 10.4 ATP4A ATP12A
30 cascade stomach 10.4 ATP4A ATP12A
31 benzylpenicillin allergy 10.4 ATP4A ATP12A
32 median arcuate ligament syndrome 10.4 ATP4A ATP12A
33 cervix erosion 10.4 ATP4A ATP12A
34 angiodysplasia of intestine 10.4 ATP4A ATP12A
35 laryngeal tuberculosis 10.4 ATP4A ATP12A
36 fungal esophagitis 10.4 ATP4A ATP12A
37 dieulafoy lesion 10.4 ATP4A ATP12A
38 emphysematous cholecystitis 10.4 ATP4A ATP12A
39 superior mesenteric artery syndrome 10.4 ATP4A ATP12A
40 chronic laryngitis 10.4 ATP4A ATP12A
41 viral laryngitis 10.4 ATP4A ATP12A
42 central nervous system origin vertigo 10.4 ATP4A ATP12A
43 internal hemorrhoid 10.4 ATP4A ATP12A
44 acute laryngitis 10.4 ATP4A ATP12A
45 barbiturate abuse 10.4 ATP4A ATP12A
46 gastric dilatation 10.4 ATP4A ATP12A
47 gastric hemangioma 10.4 ATP4A ATP12A
48 polycystic echinococcosis 10.4 ATP4A ATP12A
49 helicobacter pylori infection 10.4
50 bartholin's gland disease 10.4 CDX2 CDX1

Graphical network of the top 20 diseases related to Bile Reflux:



Diseases related to Bile Reflux
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Symptoms & Phenotypes for Bile Reflux

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MGI Mouse Phenotypes related to Bile Reflux:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 10 ALB ATP12A ATP4A BMP4 CDX1 CDX2
2 endocrine/exocrine gland MP:0005379 9.85 ALB ATP4A BMP4 CCK CDX1 CDX2
3 homeostasis/metabolism MP:0005376 9.77 ALB ATP12A ATP4A BMP4 CCK CDX2
4 neoplasm MP:0002006 9.17 ALB ATP4A CDX2 GAST NR1H4 PTGS2
Sources

Drugs & Therapeutics for Bile Reflux

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Drugs for Bile Reflux (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cimetidine Approved, Investigational Phase 4 51481-61-9 2756
2
Ranitidine Approved, Withdrawn Phase 4 66357-59-3, 66357-35-5, 82530-72-1 3001055
3
Dexlansoprazole Approved, Investigational Phase 4 138530-94-6, 103577-45-3 9578005
4
Pantoprazole Approved Phase 4 102625-70-7 4679
5
Metoclopramide Approved, Investigational Phase 4 364-62-5 4168
6
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
7
Famotidine Approved Phase 4 76824-35-6 3325
8
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
9
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 161973-10-0, 119141-88-7 9568614 4594
10
Histamine Approved, Investigational Phase 4 51-45-6, 75614-87-8 774
11
Domperidone Approved, Investigational, Vet_approved Phase 4 57808-66-9 3151
12
Rabeprazole Approved, Investigational Phase 4 117976-89-3 5029
13
Nizatidine Approved Phase 4 76963-41-2 3033637
14
Lafutidine Investigational Phase 4 118288-08-7 5282136
15 Gastrointestinal Agents Phase 4
16 Anesthetics Phase 4
17 Ranitidine bismuth citrate Phase 4
18 Antacids Phase 4
19 Anti-Ulcer Agents Phase 4
20 Histamine H2 Antagonists Phase 4
21 Proton Pump Inhibitors Phase 4
22 Neurotransmitter Agents Phase 4
23 Histamine Antagonists Phase 4
24
Histamine Phosphate Phase 4 51-74-1 65513
25 Cytochrome P-450 Enzyme Inhibitors Phase 4
26
lanreotide Approved Phase 2 108736-35-2
27 Angiopeptin Phase 2
28 Bile Acids and Salts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 "Effect of Orally Administered Two Successive Doses of PPIs and/ or H2RAs Without or With a Prokinetic Drug, on the Intragastric pH and Volume and Bile Refluxate in Adults Patients Undergoing Elective Surgery. Completed NCT02703896 Phase 4 Drug either PPIS or H2RA and prokinetics
2 Phase III Study on Comparison for Bile Reflux and Gastric Stasis in Patients With Gastric Cancer After Distal Gastrectomy Withdrawn NCT00622804 Phase 3
3 Resolving Bile Reflux by Lanreotide in Patients With Roux-en-Y Gastrojejunostomy Unknown status NCT02054637 Phase 2 Lanreotide
4 The Revolutions of Helicobacter Pylori Infection, Bacterial Density, and Histological Features After Antrectomy Unknown status NCT00441831
5 Study on the Effect of Bile Reflux on Gastric Cancer and Its Precancerous Lesions: a Multiple Center, Cross-sectional Study. Completed NCT03976739
6 The Role of Endoscopic Tri-Modal Imaging in Distinguishing Functional Dyspepsia From Reflux Disease Completed NCT02685150 Omeprazole
7 Prospective, Randomized, Controlled Trial of Omega Loop Gastric Bypass With and Without Anti-reflux Sutures - a Pilot Study Recruiting NCT03097887
8 Associations Among Serum and Gastric Juice Bile Acid Profile, Bile Acid-microbiota Cross-talk in Stomach and the Development of Gastric Cancer: A Case-control Study Not yet recruiting NCT04660058

Search NIH Clinical Center for Bile Reflux

Cochrane evidence based reviews: bile reflux

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Genetic Tests for Bile Reflux

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Anatomical Context for Bile Reflux

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MalaCards organs/tissues related to Bile Reflux:

40
Liver, Pancreas, Colon, Appendix, Bone, Endothelial, Heart
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Publications for Bile Reflux

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Articles related to Bile Reflux:

(show top 50) (show all 881)
# Title Authors PMID Year
1
Interleukin-8, cyclo-oxygenase-2, and trefoil factor family 1 gene expression and their association with Helicobacter pylori infection in the remnant stomach. 54 61
16341482 2005
2
The effect of the CCK receptor antagonist CR 1409 on bile reflux pancreatitis in the opossum. 54 61
1713673 1991
3
Pharmacokinetics and clinical application of technetium 99m-labeled hepatobiliary agents. 54 61
2184521 1990
4
Bile reflux is an independent risk factor for precancerous gastric lesions and gastric cancer: An observational cross-sectional study. 61
33793080 2021
5
The IFSO Worldwide One Anastomosis Gastric Bypass Survey: Techniques and Outcomes? 61
33517557 2021
6
Omega Loop Gastroileal Bypass (OLGIBP/SAGI) Versus One Anastomosis Gastric Bypass (OAGB): Medium-Term Results. 61
33409980 2021
7
SADI-S 250 vs Roux-en-Y Duodenal Switch (RY-DS): Results of 5-Year Observational Study. 61
33047290 2021
8
Functional Outcomes of Delta-Shaped Anastomosis After Laparoscopic Distal Gastrectomy. 61
32026335 2021
9
Twenty years' experience of laparoscopic 1-anastomosis gastric bypass: surgical risk and long-term results. 61
33619007 2021
10
Total Laparoscopic Uncut Roux-en-Y for Radical Distal Gastrectomy: An Interim Analysis of a Randomized, Controlled, Clinical Trial. 61
32556870 2021
11
Single Anastomosis Duodeno-ileostomy (SADI-S) Versus One Anastomosis Gastric Bypass (OAGB-MGB) as Revisional Procedures for Patients with Weight Recidivism After Sleeve Gastrectomy: a Comparative Analysis of Efficacy and Outcomes. 61
32845477 2020
12
Bile reflux in patients with nerd is associated with more severe heartburn and lower values of mean nocturnal baseline impedance and chemical clearance. 61
32573065 2020
13
[Comparison of different reconstruction procedures after distal gastrectomy in patients with gastric cancer]. 61
33371636 2020
14
Development of Barrett's esophagus after a total gastrectomy. 61
33054276 2020
15
[Efficacy and safety of pylorus-preserving gastrectomy for early gastric cancer located in the middle third of the stomach: a meta-analysis]. 61
33212558 2020
16
Comparison of the Long-term Outcome Between Billroth-I and Roux-en-Y Reconstruction Following Distal Gastrectomy for Gastric Cancer. 61
33205309 2020
17
Postoperative Clinical-Endoscopic Follow-up for GERD and Gastritis After One Anastomosis Gastric Bypass for Morbid Obesity: How, When, and Why. 61
32621053 2020
18
Intestinal metaplasia around the gastroesophageal junction is frequently associated with antral reactive gastropathy: implications for carcinoma at the gastroesophageal junction. 61
32941964 2020
19
[Significance of celiac branch of the vagal nerve in function-preserving gastrectomy]. 61
33053987 2020
20
Laparoscopic Hiatal Hernia Repair and Roux-en-Y Conversion for Refractory Duodenogastroesophageal Reflux after Billroth I Distal Gastrectomy. 61
33024589 2020
21
The temporal effects of topical NF-κB inhibition, in the in vivo prevention of bile-related oncogenic mRNA and miRNA phenotypes in murine hypopharyngeal mucosa: a preclinical model. 61
32934775 2020
22
The in vivo preventive and therapeutic properties of curcumin in bile reflux-related oncogenesis of the hypopharynx. 61
32691972 2020
23
Gastric xanthelasma may be a warning sign of intestinal metaplasia: A cross‑sectional study. 61
32583002 2020
24
The Optimal Pyloric Procedure: A Collective Review. 61
32793458 2020
25
Initial experience of single-incision plus one port left-side approach totally laparoscopic distal gastrectomy with uncut Roux-en-Y reconstruction. 61
32884224 2020
26
The Learning Curve of Linear-Shaped Gastroduodenostomy Associated with Totally Laparoscopic Distal Gastrectomy. 61
31325136 2020
27
Unexpected Biliopancreatic Limb Obstruction after Gastric Bypass Revision. 61
32418189 2020
28
Robotic Excision of Choledochal Cyst with Hepaticoduodenostomy (HD): Report of HD Technique, Initial Experience, and Early Outcome. 61
32668486 2020
29
A comparison between pylorus-preserving and distal gastrectomy in surgical safety and functional benefit with gastric cancer: a systematic review and meta-analysis. 61
32641052 2020
30
[Prevention of closure point recanalization after uncut Roux-en-Y anastomosis for radical resection of distal gastric cancer]. 61
32683835 2020
31
Association between hiatal hernia and gastroesophageal reflux symptoms after one-anastomosis/mini gastric bypass. 61
32331999 2020
32
Bile Reflux After One Anastomosis Gastric Bypass. 61
32277329 2020
33
Increased levels of conjugated bile acids are associated with human bile reflux gastritis. 61
32665615 2020
34
The role of bile reflux and its related NF-κB activated pathway in progression of hypopharyngeal squamous cell cancer. 61
32247988 2020
35
Cardia Gastric Cancer in the Gastric Pouch 5 Years after Gastric Bypass: A Case Report. 61
32078104 2020
36
Internal Hernia Following Primary Laparoscopic SADI-S: the First Reported Case. 61
32124214 2020
37
HIDA and Seek: Challenges of Scintigraphy to Diagnose Bile Reflux Post-Bariatric Surgery. 61
32133588 2020
38
Indications, Operative Techniques, and Outcomes for Revisional Operation Following Mini-Gastric Bypass-One Anastomosis Gastric Bypass: a Systematic Review. 61
31982993 2020
39
The relationship between gastric cancer, its precancerous lesions and bile reflux: A retrospective study. 61
32187838 2020
40
Spade-Shaped Anastomosis Following a Proximal Gastrectomy Using a Double Suture to Fix the Posterior Esophageal Wall to the Anterior Gastric Wall (SPADE Operation): Case-Control Study of Early Outcomes. 61
32269846 2020
41
Clinical Outcomes of One Anastomosis Gastric Bypass Versus Sleeve Gastrectomy for Morbid Obesity. 61
31797208 2020
42
Simplified percutaneous endoscopic transgastric conduit feeding jejunostomy for dysphagia after esophagectomy. 61
31069391 2020
43
Bile Reflux is a Common Finding in the Gastric Pouch After One Anastomosis Gastric Bypass. 61
31853864 2020
44
Conversion from mini bypass to laparoscopic Roux en Y gastric bypass in an emergency setting: Case report and literature review. 61
32901216 2020
45
Proton Pump Inhibitors and Radiofrequency Ablation for Treatment of Barrett's Esophagus. 61
31644405 2020
46
Comparison of the Clinical Outcomes Between Isoperistaltic and Antiperistaltic Anastomoses After Laparoscopic Distal Gastrectomy for Patients With Gastric Cancer. 61
32850372 2020
47
Efficacy of Celiac Branch Preservation in Billroth-â…  Reconstruction After Laparoscopy-Assisted Distal Gastrectomy. 61
31425872 2020
48
Comparative Study on Effect of Rabeprazole Versus Omeprazole in Acid-peptic Disorder with Helicobacter pylori Infection. 61
32001852 2020
49
Laparoscopic One-Anastomosis Gastric Bypass with Band-Separated Gastric Pouch (OAGB-BSGP): a Randomized Controlled Trial. 61
31654345 2019
50
Prospective randomized controlled trial comparing the efficacy and safety of Roux-en-Y gastric bypass and one-anastomosis gastric bypass (the RYSA trial): trial protocol and interim analysis. 61
31888729 2019
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Variations for Bile Reflux

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Expression for Bile Reflux

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Search GEO for disease gene expression data for Bile Reflux.
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Pathways for Bile Reflux

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Pathways related to Bile Reflux according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Salivary secretion 36
Show member pathways
 11.99 SCT GAST CCK ATP4A
2
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.38 CDX2 CDX1 BMP4 ALB
3
Secretion of Hydrochloric Acid in Parietal Cells 1
9.85 GAST ATP4A
4
Gastric acid production 1
9.64 SCT GAST CCK
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GO Terms for Bile Reflux

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Cellular components related to Bile Reflux according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 TFF1 SCT S100A8 MUC5AC MLN GAST
2 extracellular space GO:0005615 9.28 TFF1 SCT S100A8 MUC5AC GAST CCK

Biological processes related to Bile Reflux according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular sodium ion homeostasis GO:0006883 9.43 ATP4A ATP12A
2 embryo development GO:0009790 9.4 CDX2 CDX1
3 sodium ion export across plasma membrane GO:0036376 9.37 ATP4A ATP12A
4 cellular potassium ion homeostasis GO:0030007 9.32 ATP4A ATP12A
5 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.26 ATP4A ATP12A
6 regulation of somitogenesis GO:0014807 9.16 CDX2 CDX1
7 cellular response to bile acid GO:1903413 8.96 NR1H4 GPBAR1
8 anterior/posterior axis specification GO:0009948 8.8 CDX2 CDX1 BMP4

Molecular functions related to Bile Reflux according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.32 ATP4A ATP12A
2 potassium-transporting ATPase activity GO:0008556 9.26 ATP4A ATP12A
3 hormone activity GO:0005179 9.26 SCT MLN GAST CCK
4 potassium:proton exchanging ATPase activity GO:0008900 9.16 ATP4A ATP12A
5 bile acid receptor activity GO:0038181 8.62 NR1H4 GPBAR1
Sources

Sources for Bile Reflux

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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