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MCID: BLR002
MIFTS: 36

Bile Reflux

Categories: Gastrointestinal diseases, Liver diseases
Genes Tissues Related diseases Publications Drugs
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Aliases & Classifications for Bile Reflux

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MalaCards integrated aliases for Bile Reflux:

Name: Bile Reflux 12 55 44 15 73

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases Liver diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:12237
MeSH 44 D001655
UMLS 73 C0005403
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Summaries for Bile Reflux

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MalaCards based summary : Bile Reflux is related to gastric ulcer and peptic esophagitis. An important gene associated with Bile Reflux is CCK (Cholecystokinin). The drugs Omeprazole and Famotidine have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and lymph node, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

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Related Diseases for Bile Reflux

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Diseases related to Bile Reflux via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)
# Related Disease Score Top Affiliating Genes
1 gastric ulcer 30.3 PTGS2 TFF1
2 peptic esophagitis 30.3 ATP12A ATP4A
3 gastroesophageal reflux 30.0 CCK CDX2 PTGS2
4 dyspepsia 29.9 CCK PTGS2
5 peptic ulcer disease 29.8 ATP4A PTGS2
6 barrett esophagus 29.5 CDX2 PTGS2 TFF1
7 gastritis 10.7
8 degos 'en cocarde' erythrokeratoderma 10.5
9 pancreatitis 10.4
10 helicobacter pylori infection 10.2
11 esophagitis 10.2
12 acute pancreatitis 10.2
13 fungal esophagitis 10.1 ATP12A ATP4A
14 diclofenac allergy 10.1 ATP12A ATP4A
15 gastroduodenal crohn's disease 10.1 ATP12A ATP4A
16 neonatal candidiasis 10.1 ATP12A ATP4A
17 squamous papillomatosis 10.1 ATP12A ATP4A
18 toxic megacolon 10.1 ATP12A ATP4A
19 aspiration pneumonitis 10.1 ATP12A ATP4A
20 gastrointestinal neuroendocrine benign tumor 10.1 ATP12A ATP4A
21 gastric antral vascular ectasia 10.1 ATP12A ATP4A
22 granulomatous gastritis 10.1 ATP12A ATP4A
23 esophageal candidiasis 10.1 ATP12A ATP4A
24 gastric neuroendocrine neoplasm 10.1 ATP12A ATP4A
25 acute laryngitis 10.1 ATP12A ATP4A
26 laryngitis 10.1 ATP12A ATP4A
27 duodenitis 10.1 ATP12A ATP4A
28 rumination disorder 10.1 ATP12A ATP4A
29 congenital disorder of deglycosylation 10.1 ATP12A ATP4A
30 bladder calculus 10.1 ATP12A ATP4A
31 ischemic neuropathy 10.1 ATP12A ATP4A
32 capillary disease 10.1 ATP12A ATP4A
33 dyskinesia of esophagus 10.1 ATP12A ATP4A
34 hernia, hiatus 10.1 ATP12A ATP4A
35 anismus 10.1 ATP12A ATP4A
36 postsurgical hypothyroidism 10.1 ATP12A ATP4A
37 lymphocytic colitis 10.1 ATP12A ATP4A
38 esophageal atresia/tracheoesophageal fistula 10.1 ATP12A ATP4A
39 clostridium difficile colitis 10.1 ATP12A ATP4A
40 diarrhea 1, secretory chloride, congenital 10.1 ATP12A ATP4A
41 microscopic colitis 10.1 ATP12A ATP4A
42 laryngeal tuberculosis 10.1 ATP12A ATP4A
43 chronic laryngitis 10.1 ATP12A ATP4A
44 eosinophilic gastritis 10.1 ATP12A ATP4A
45 chronic intestinal vascular insufficiency 10.1 ATP12A ATP4A
46 jejunoileitis 10.1 ATP12A ATP4A
47 esophageal varix 10.1 ATP12A ATP4A
48 gastric lymphoma 10.1 ATP12A ATP4A
49 lower urinary tract calculus 10.1 ATP12A ATP4A
50 myopathy, x-linked, with excessive autophagy 10.1 ATP12A ATP4A

Graphical network of the top 20 diseases related to Bile Reflux:



Diseases related to Bile Reflux
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Symptoms & Phenotypes for Bile Reflux

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MGI Mouse Phenotypes related to Bile Reflux:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.7 ATP12A ATP4A CDX1 CDX2 PCSK5 PTGS2
2 endocrine/exocrine gland MP:0005379 9.43 ATP4A CCK CDX1 CDX2 PCSK5 PTGS2
3 neoplasm MP:0002006 8.92 ATP4A CDX2 PTGS2 TFF1
Sources

Drugs & Therapeutics for Bile Reflux

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Drugs for Bile Reflux (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Omeprazole Approved, Investigational, Vet_approved Phase 4,Not Applicable 73590-58-6 4594
2
Famotidine Approved Phase 4 76824-35-6 3325
3
Metoclopramide Approved, Investigational Phase 4 364-62-5 4168
4
Domperidone Approved, Investigational, Vet_approved Phase 4 57808-66-9 3151
5
Pantoprazole Approved Phase 4 102625-70-7 4679
6
Histamine Approved, Investigational Phase 4 51-45-6, 75614-87-8 774
7
Cimetidine Approved, Investigational Phase 4 51481-61-9 2756
8
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
9
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
10
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 119141-88-7 4594 9579578
11
Rabeprazole Approved, Investigational Phase 4 117976-89-3 5029
12
Nizatidine Approved Phase 4 76963-41-2 3033637
13
Ranitidine Approved Phase 4 66357-35-5, 66357-59-3 3001055
14
Dexlansoprazole Approved, Investigational Phase 4 103577-45-3, 138530-94-6 9578005
15
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
16
Lafutidine Investigational Phase 4 118288-08-7 5282136
17 Neurotransmitter Agents Phase 4,Phase 2
18 Dopamine D2 Receptor Antagonists Phase 4
19 Histamine Antagonists Phase 4
20 Antacids Phase 4,Not Applicable
21 Cytochrome P-450 Enzyme Inhibitors Phase 4
22 Peripheral Nervous System Agents Phase 4
23 Citrate Phase 4
24 Anesthetics Phase 4
25 Antiemetics Phase 4
26 Anti-Ulcer Agents Phase 4,Not Applicable
27 Proton Pump Inhibitors Phase 4,Not Applicable
28 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
29 Dopamine Antagonists Phase 4
30 Ranitidine bismuth citrate Phase 4
31
Histamine Phosphate Phase 4 51-74-1 65513
32 Dopamine Agents Phase 4
33 Gastrointestinal Agents Phase 4,Not Applicable
34
Bismuth Phase 4 7440-69-9 16682734 105143
35 Bismuth tripotassium dicitrate Phase 4
36 Autonomic Agents Phase 4
37 Histamine H2 Antagonists Phase 4
38
Somatostatin Approved, Investigational Phase 2 51110-01-1, 38916-34-6 53481605
39 lanreotide Approved Phase 2 108736-35-2
40
Imidacloprid Vet_approved Phase 2 105827-78-9 86418
41 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
42 Hormone Antagonists Phase 2
43 Angiopeptin Phase 2
44 Hormones Phase 2
45 Cholinergic Agents Phase 2
46
Loperamide Approved Not Applicable 53179-11-6 3955
47 Antidiarrheals Not Applicable

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Prophylaxis for Aspiration of Gastric Contents. Completed NCT02703896 Phase 4 Drug either PPIS or H2RA and prokinetics
2 Comparison Study for Bile Reflux and Gastric Stasis in Patients After Distal Gastrectomy Withdrawn NCT00622804 Phase 3
3 Resolving Bile Reflux by Lanreotide in Patients With Roux-en-Y Gastrojejunostomy Unknown status NCT02054637 Phase 2 Lanreotide
4 The Advantages and Disadvantages Between Uncut Roux-en-Y Reconstruction and Billroth II Reconstruction After Laparoscopy-assisted Distal Gastrectomy for Gastric Unknown status NCT02694081 Phase 2
5 The Revolutions of Helicobacter Pylori Infection, Bacterial Density, and Histological Features After Antrectomy Unknown status NCT00441831
6 Endoscopic Tri-Modal Imaging to Distinguish Functional Dyspepsia From Reflux Disease Completed NCT02685150 Not Applicable Omeprazole
7 Comparison of Mini Gastric Bypass and Roux-en-Y Gastric Bypass Recruiting NCT02882685 Not Applicable
8 the Laparoscopic and Endoscopic Cooperative Surgery of Gastrointestinal Stromal Tumor Recruiting NCT02763748 Not Applicable
9 Three M Study (Malabsorption, Microbiota, Mini-Gastric Bypass) Recruiting NCT03412149 Not Applicable
10 Laparoscopic Endoscopic Cooperative Surgery in the Treatment of Gastric Stromal Tumors Recruiting NCT03601234 Not Applicable
11 Uncut Roux-en-Y vs Roux-en-Y Recruiting NCT03349398 Not Applicable
12 Endoscopic Complications After Gastric Bypass Active, not recruiting NCT03532646 Not Applicable
13 Omega Loop Gastric Bypass With And Without Anti-Reflux Sutures Not yet recruiting NCT03097887 Not Applicable
14 Comparison of Open Laparoscopic and Robotic Surgery in Gastric Cancer Resection. Not yet recruiting NCT03447106 Not Applicable
15 Comparative Study of Antiperistaltic vs Isoperistaltic Billroth II + Braun Anastomosis for Postoperative Reflux Not yet recruiting NCT03372681 Not Applicable

Search NIH Clinical Center for Bile Reflux

Cochrane evidence based reviews: bile reflux

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Genetic Tests for Bile Reflux

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Anatomical Context for Bile Reflux

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MalaCards organs/tissues related to Bile Reflux:

41
Liver, Testes, Lymph Node, Pancreas, Skin, Colon
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Publications for Bile Reflux

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Articles related to Bile Reflux:

(show top 50) (show all 204)
# Title Authors Year
1
Gastrogastric Fistula: an Unusual Cause for Severe Bile Reflux Following Conversion of Sleeve Gastrectomy to One Anastomosis Gastric Bypass. ( 29728987 )
2018
2
New Causes for the Old Problem of Bile Reflux Gastritis. ( 29505908 )
2018
3
Response to a Letter to the Editor Re: Detecting Bile Reflux-the Enigma of Bariatric Surgery. ( 29744716 )
2018
4
Detecting Bile Reflux-the Enigma of Bariatric Surgery. ( 29671122 )
2018
5
Detecting Bile Reflux-the Enigma of Bariatric Surgery. ( 29230622 )
2018
6
Curcumin prevents the bile reflux-induced NF-I_B-related mRNA oncogenic phenotype, in human hypopharyngeal cells. ( 29911313 )
2018
7
A study on the roles of Helicobacter pylori in bile reflux gastritis and gastric cancer. ( 30003734 )
2018
8
Quality of life and impact of bile reflux after retro colic retro gastric gastrojejunostomy in Whipple surgery. ( 28109253 )
2017
9
Remnant gastropathy due to bile reflux after Roux-en-Y gastric bypass: a unique cause of abdominal pain and successful treatment with ursodiol. ( 28799115 )
2017
10
Bile reflux of the remnant stomach following Roux-en-Y gastric bypass: an etiology of chronic abdominal pain treated with remnant gastrectomy. ( 28576682 )
2017
11
Bile Reflux Scintigraphy After Mini-Gastric Bypass. ( 28214959 )
2017
12
Correlation Between Bile Reflux Gastritis and Biliary Excreted Contrast Media in the Stomach. ( 28240637 )
2017
13
Does Braun Anastomosis Have an Impact on the Incidence of Delayed Gastric Emptying and the Extent of Intragastric Bile Reflux Following Pancreatoduodenectomy? - A Randomized Controlled Study. ( 28132059 )
2017
14
Laparoscopic Conversion of One Anastomosis Gastric Bypass to Roux-en-Y Gastric Bypass for Chronic Bile Reflux. ( 26746224 )
2016
15
Conversion of one anastomosis gastric bypass/mini gastric bypass to Roux-en-Y gastric bypass for bile reflux gastritis after failed Braun jejunojejunostomy. ( 27986575 )
2016
16
Laparoscopic conversion of one anastomosis gastric bypass/mini gastric bypass to Roux-en-Y gastric bypass for bile reflux gastritis. ( 27825579 )
2016
17
Rabeprazole is effective for bile reflux oesophagitis after total gastrectomy in a rat model. ( 25685608 )
2015
18
Clinical significance of bile reflux into the pancreatic duct without pancreaticobiliary maljunction assessed by intraoperative cholangiography. ( 25756368 )
2015
19
Evaluation of bile reflux in HIDA images based on fluid mechanics. ( 25754361 )
2015
20
Dietary and Medicinal Herbal Recommendation for Management of Primary Bile Reflux Gastritis in Traditional Persian Medicine. ( 26587489 )
2015
21
Does Bile Reflux Influence the Progression of Barrett's Esophagus to Adenocarcinoma? (Gastroenterology 2013;145:1300-1311). ( 24466454 )
2014
22
Resolving bile reflux by lanreotide in patients with Roux-en-Y gastrojejunostomy. ( 25682623 )
2014
23
Uncut Roux-en-Y Reconstruction after Laparoscopic Distal Gastrectomy Can Be a Favorable Method in Terms of Gastritis, Bile Reflux, and Gastric Residue. ( 25580354 )
2014
24
Management of bile reflux. ( 23961269 )
2013
25
Bridging across the ampulla with metal stents: evidences for intestinal bile reflux. ( 24719925 )
2013
26
The effects of chronic bile reflux on the gastric mucosa of rats. ( 24226718 )
2013
27
Histological features of the gastric mucosa in children with primary bile reflux gastritis. ( 22289498 )
2012
28
A modified laparoscopic esophagogastric dissociation for severe bile reflux in a neurologically impaired child. ( 23084208 )
2012
29
Opie's hypothesis revisited: acute pancreatitis due to bile reflux into the pancreas. ( 22487472 )
2012
30
The histological and immunohistochemical aspects of bile reflux in patients with gastroesophageal reflux disease. ( 21822428 )
2011
31
Emerging concepts of bile reflux in the constellation of gastroesophageal reflux disease. ( 19756880 )
2010
32
The role of acid and bile reflux in oesophagitis and Barrett's metaplasia. ( 20298181 )
2010
33
Laparoscopic revision of Roux-en-Y gastric bypass for dysphagia and bile reflux. ( 20870186 )
2010
34
Ketamine suppresses LPS-induced bile reflux and gastric bleeding in the rat. ( 20065760 )
2010
35
Rabeprazole combined with hydrotalcite is effective for patients with bile reflux gastritis after cholecystectomy. ( 20352149 )
2010
36
Comment on: Bile reflux after Roux-en-Y gastric bypass: an unrecognized cause of postoperative pain (Swartz DE, et al. 2009;5:27-30). ( 19306824 )
2009
37
Bile reflux after Roux-en-Y gastric bypass: an unrecognized cause of postoperative pain. ( 19095503 )
2009
38
The key event of acute pancreatitis: pancreatic duct obstruction and bile reflux, not a single one can be omitted. ( 19147295 )
2009
39
The significance of histological evidence of bile reflux gastropathy in patients with gastro-esophageal reflux disease. ( 19478703 )
2009
40
Prevalence of bile reflux in gastroesophageal reflux disease patients not responsive to proton pump inhibitors. ( 19140233 )
2009
41
Role of bile reflux and Helicobacter pylori infection on inflammation of gastric remnant after distal gastrectomy. ( 18959592 )
2008
42
Comments on the publication "effect of pyloric drainage procedures on gastric passage and bile reflux after esophagectomy with gastric conduit reconstruction by Palmes et al.". ( 17992536 )
2008
43
Effect of cholecystectomy on gastric and esophageal bile reflux in patients with upper gastrointestinal symptoms. ( 17939040 )
2008
44
Bile reflux index after therapeutic biliary procedures. ( 18267026 )
2008
45
Acid and bile reflux in erosive reflux disease, non-erosive reflux disease and Barrett's esophagus. ( 18613384 )
2008
46
Effect of pyloric drainage procedures on gastric passage and bile reflux after esophagectomy with gastric conduit reconstruction. ( 17216285 )
2007
47
Do acid and bile reflux into the esophagus simultaneously? Temporal relationship between duodenogastro-esophageal reflux and esophageal pH. ( 17445043 )
2007
48
Bile reflux in the esophagus demonstrated by HIDA scintigraphy. ( 17314604 )
2007
49
Bile reflux measurement and its contribution to the severity of reflux esophagitis. ( 19858643 )
2007
50
Bile-reflux into the pancreatic ducts is associated with the development of intraductal papillary carcinoma in hamsters. ( 16863651 )
2006
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Variations for Bile Reflux

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Expression for Bile Reflux

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Search GEO for disease gene expression data for Bile Reflux.
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Pathways for Bile Reflux

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GO Terms for Bile Reflux

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Biological processes related to Bile Reflux according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 memory GO:0007613 9.51 CCK PTGS2
2 pattern specification process GO:0007389 9.49 CDX1 CDX2
3 embryo implantation GO:0007566 9.48 PCSK5 PTGS2
4 potassium ion import across plasma membrane GO:1990573 9.46 ATP12A ATP4A
5 potassium ion import GO:0010107 9.43 ATP12A ATP4A
6 ATP hydrolysis coupled proton transport GO:0015991 9.4 ATP12A ATP4A
7 cellular sodium ion homeostasis GO:0006883 9.37 ATP12A ATP4A
8 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.32 ATP12A ATP4A
9 cellular potassium ion homeostasis GO:0030007 9.26 ATP12A ATP4A
10 sodium ion export across plasma membrane GO:0036376 9.16 ATP12A ATP4A
11 anterior/posterior pattern specification GO:0009952 9.13 CDX1 CDX2 PCSK5
12 regulation of somitogenesis GO:0014807 8.62 CDX1 CDX2

Molecular functions related to Bile Reflux according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 methyl-CpG binding GO:0008327 9.16 CDX1 CDX2
2 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
3 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A
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Sources for Bile Reflux

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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