Bile Reflux disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Bile Reflux

MalaCards integrated aliases for Bile Reflux:

Name: Bile Reflux ¹¹ ⁵³ ⁴³ ¹⁴ ¹⁶ ⁷¹

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases Liver diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:12237

MeSH ⁴³ D001655

EFO ¹⁶ EFO_1000838

UMLS ⁷¹ C0005403

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Summaries for Bile Reflux

Disease Ontology: ¹¹ A biliary tract disease characterized by the flow of bile up into the stomach and/or esophagus.

MalaCards based summary: Bile Reflux is related to gastritis and duodenal ulcer. An important gene associated with Bile Reflux is STAT3 (Signal Transducer And Activator Of Transcription 3), and among its related pathways/superpathways are Gastrin signaling pathway and Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers. The drugs Lanreotide and Esomeprazole have been mentioned in the context of this disorder. Affiliated tissues include tongue, liver and pancreas, and related phenotypes are Reduced mammosphere formation and homeostasis/metabolism

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Related Diseases for Bile Reflux

Diseases related to Bile Reflux via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 267)

#	Related Disease	Score	Top Affiliating Genes
1	gastritis	31.6	S100A8 PTGS2 GAST CDX2 ATP4A
2	duodenal ulcer	30.6	S100A8 GAST CCK
3	gastric ulcer	30.4	TFF1 S100A8 PTGS2 GAST ATP12A
4	postcholecystectomy syndrome	30.2	GAST CCK
5	duodenogastric reflux	30.2	MIR92A1 GPBAR1 GAST CCK ATP4A ATP12A
6	gastroesophageal reflux	30.2	S100A8 PTGS2 GAST CDX2 CCK ATP4A
7	esophagus adenocarcinoma	30.2	PTGS2 CDX2 ATP4A ATP12A
8	biliary dyskinesia	30.2	CCK ATP4A ATP12A
9	pernicious anemia	30.1	GAST ATP4A ATP12A
10	gallbladder disease	29.9	NR1H4 CCK ALB
11	cholangitis	29.9	NR1H4 GPBAR1 ALB
12	fungal infectious disease	29.8	STAT3 ATP4A ATP12A ALB
13	gastrointestinal system disease	29.8	S100A8 MIR92A1 GAST CCK
14	cardia cancer	29.7	S100A8 GAST ATP4A ATP12A
15	cholelithiasis	29.7	NR1H4 GAST CCK ALB
16	barrett esophagus	29.5	TFF1 S100A8 PTGS2 NR1H4 MUC5AC GAST
17	cholecystitis	29.5	TFF1 S100A8 MUC5AC CCK ALB
18	microinvasive gastric cancer	29.4	S100A8 MUC5AC GAST CDX2 ATP4A ATP12A
19	peptic ulcer disease	29.3	S100A8 PTGS2 MUC5AC GAST CCK ATP4A
20	esophageal disease	29.3	MIR92A1 ATP4A ATP12A ALB
21	peptic esophagitis	29.3	S100A8 PTGS2 LAT2 GAST CDX2 ATP4A
22	esophageal cancer	28.9	STAT3 PTGS2 MIR92A1 CDX2 ATP4A ATP12A
23	gastric cancer	28.8	TFF1 STAT3 S100A8 PTGS2 MUC5AC GAST
24	atrophic gastritis	28.8	TFF1 S100A8 PTGS2 MIR92A1 GAST CDX2
25	cystic fibrosis	28.7	STAT3 S100A8 PTGS2 MUC5AC CCK ATP12A
26	pancreatic cancer	28.3	TFF1 STAT3 PTGS2 MUC5AC MIR92A1 GAST
27	esophagitis	10.5
28	helicobacter pylori infection	10.5
29	pancreatic vasoactive intestinal peptide producing tumor	10.4	ATP4A ATP12A
30	acquired laryngomalacia	10.4	ATP4A ATP12A
31	scalp dermatosis	10.4	ATP4A ATP12A
32	acquired gastric outlet stenosis	10.3	ATP4A ATP12A
33	lingual goiter	10.3	ATP4A ATP12A
34	esophageal diverticulosis	10.3	ATP4A ATP12A
35	benign shuddering attacks	10.3	ATP4A ATP12A
36	persistent moderate asthma	10.3	ATP4A ATP12A
37	viral esophagitis	10.3	ATP4A ATP12A
38	cervix erosion	10.3	ATP4A ATP12A
39	bacterial esophagitis	10.3	ATP4A ATP12A
40	angiodysplasia of intestine	10.3	ATP4A ATP12A
41	angiodysplasia	10.3	ATP4A ATP12A
42	benzylpenicillin allergy	10.3	ATP4A ATP12A
43	penicillin allergy	10.3	ATP4A ATP12A
44	fungal esophagitis	10.3	ATP4A ATP12A
45	emphysematous cholecystitis	10.3	ATP4A ATP12A
46	afferent loop syndrome	10.3	ATP4A ATP12A
47	laryngeal tuberculosis	10.3	ATP4A ATP12A
48	gastrojejunal ulcer	10.3	ATP4A ATP12A
49	cefuroxime allergy	10.3	ATP4A ATP12A
50	median arcuate ligament syndrome	10.3	ATP4A ATP12A

Graphical network of the top 20 diseases related to Bile Reflux:

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Symptoms & Phenotypes for Bile Reflux

GenomeRNAi Phenotypes related to Bile Reflux according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Reduced mammosphere formation	GR00396-S	9.1	ALB ATP4A MUC5AC NR1H4 PTGS2 STAT3

MGI Mouse Phenotypes related to Bile Reflux:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10	ALB ATP12A ATP4A CCK CDX2 EPC2
2	neoplasm	MP:0002006	9.86	ALB ATP4A CDX2 GAST NR1H4 PTGS2
3	endocrine/exocrine gland	MP:0005379	9.65	ALB ATP4A CCK CDX1 CDX2 GAST
4	digestive/alimentary	MP:0005381	9.36	ALB ATP12A ATP4A CDX1 CDX2 GAST

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Drugs & Therapeutics for Bile Reflux

Drugs for Bile Reflux (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Lanreotide

Approved

Phase 2

108736-35-2

71349 6918011

2

Esomeprazole

Approved, Investigational, Vet_approved

73590-58-6, 119141-88-7

9568614 4594

3

bilirubin

635-65-4

5280352

Synonyms:

(4Z,15Z)-Bilirubin ixa

(Z,Z)-Bilirubin ixa

1,10,19,22,23,24-Hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinylbiline-8,12-dipropionate

1,10,19,22,23,24-Hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-biline-8,12-dipropionate

1,10,19,22,23,24-Hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinylbiline-8,12-dipropionic acid

1,10,19,22,23,24-Hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-biline-8,12-dipropionic acid

2,17-Diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropanoate

2,17-Diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropanoic acid

2,7,13,17-Tetramethyl-1,19-dioxo-3,18-divinyl-1,10,19,22,23,24-hexahydro-21H-biline-8,12-dipropanoate

2,7,13,17-Tetramethyl-1,19-dioxo-3,18-divinyl-1,10,19,22,23,24-hexahydro-21H-biline-8,12-dipropanoic acid

3-(2-((3-(2-Carboxyethyl)-4-methyl-5-((3-methyl-5-oxo-4-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl)-1H-pyrrol-2-yl)methyl)-4-methyl-5-((4-methyl-5-oxo-3-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl)-1H-pyrrol-3-yl)propanoate

3-(2-((3-(2-Carboxyethyl)-4-methyl-5-((3-methyl-5-oxo-4-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl)-1H-pyrrol-2-yl)methyl)-4-methyl-5-((4-methyl-5-oxo-3-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid

3-(2-((3-(2-Carboxyethyl)-4-methyl-5-[(Z)-(3-methyl-5-oxo-4-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl]-1H-pyrrol-2-yl)methyl)-4-methyl-5-[(Z)-(4-methyl-5-oxo-3-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene

3-[2-[[3-(2-Carboxyethyl)-5-[(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoate

3-[2-[[3-(2-Carboxyethyl)-5-[(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid

3-[2-[[3-(2-Carboxyethyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(Z)-(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoate

3-[2-[[3-(2-Carboxyethyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(Z)-(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid

8,12-Bis(2-carboxyethyl)-2,7,13,17-tetramethyl-3,18-divinylbiladiene-ac-1,19(21H,24H)-dione

BILIRUBIN

Bilirubin IX alpha

Bilirubin ixalpha

Bilirubin IX-alpha

Bilirubin(Z,Z)

Bilirubin-ixalpha

Cholerythrin

Hematoidin

NSC-26685

4

Anti-Ulcer Agents

5

Antacids

6

Proton Pump Inhibitors

7

Gastrointestinal Agents

8

Bile Acids and Salts

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Phase III Study on Comparison for Bile Reflux and Gastric Stasis in Patients With Gastric Cancer After Distal Gastrectomy	Withdrawn	NCT00622804	Phase 3
2	Resolving Bile Reflux by Lanreotide in Patients With Roux-en-Y Gastrojejunostomy	Unknown status	NCT02054637	Phase 2	Lanreotide
3	Prospective, Randomized, Controlled Trial of Omega Loop Gastric Bypass With and Without Anti-reflux Sutures - a Pilot Study	Unknown status	NCT03097887
4	The Revolutions of Helicobacter Pylori Infection, Bacterial Density, and Histological Features After Antrectomy	Unknown status	NCT00441831
5	Bile Reflux Gastropathy: Prevalence and Risk Factors After Therapeutic Biliary Interventions: A Retrospective Cohort Study	Completed	NCT05131802
6	Study on the Effect of Bile Reflux on Gastric Cancer and Its Precancerous Lesions: a Multiple Center, Cross-sectional Study.	Completed	NCT03976739
7	The Role of Endoscopic Tri-Modal Imaging in Distinguishing Functional Dyspepsia From Reflux Disease	Completed	NCT02685150		Omeprazole
8	Evaluation of Biliary Reflux After Mini-gastric Bypass With Using the Biliary Reflux Index	Recruiting	NCT04845438
9	Associations Among Serum and Gastric Juice Bile Acid Profile, Bile Acid-microbiota Cross-talk in Stomach and the Development of Gastric Cancer: A Case-control Study	Enrolling by invitation	NCT04660058
10	Analysing the Link Between Tongue Signs and Bile Reflux by Artificial Intelligence	Not yet recruiting	NCT05369572

Search NIH Clinical Center for Bile Reflux

Cochrane evidence based reviews: bile reflux

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Genetic Tests for Bile Reflux

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Anatomical Context for Bile Reflux

Organs/tissues related to Bile Reflux:

MalaCards : Tongue, Liver, Pancreas, Colon, Endothelial, Bone

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Publications for Bile Reflux

Articles related to Bile Reflux:

(show top 50) (show all 974)

#	Title	Authors	PMID	Year
1	Interleukin-8, cyclo-oxygenase-2, and trefoil factor family 1 gene expression and their association with Helicobacter pylori infection in the remnant stomach. ⁵³ ⁶²	Xing C...Tajiri T	16341482	2005
2	The effect of the CCK receptor antagonist CR 1409 on bile reflux pancreatitis in the opossum. ⁵³ ⁶²	Larsen F...Kaminski DL	1713673	1991
3	Pharmacokinetics and clinical application of technetium 99m-labeled hepatobiliary agents. ⁵³ ⁶²	Krishnamurthy GT...Turner FE	2184521	1990
4	Negative correlations between bile reflux gastritis and Helicobacter pylori infection. ⁶²	Zhuo XH...Lu Y	35840539	2022
5	A Gastrectomy for early-stage gastric cancer patients with or without preserving celiac branches of vagus nerves: A meta-analysis. ⁶²	Jin T...Yang K	36379744	2022
6	Effect of hiatus hernia on reflux patterns and mucosal integrity in patients with non-erosive reflux disease. ⁶²	Sawada A...Sifrim D	35593218	2022
7	A Single-site Interventional Study on the Contemporary Relevance of Braun Enteroenterostomy After Pancreaticoduodenectomy. ⁶²	Tanaka T...Eguchi S	36340448	2022
8	A 3-year follow-up study of uncut Roux-en-Y reconstruction: clinical results and outcomes. ⁶²	Chung JH...Lee SH	35380283	2022
9	[From mini gastric bypass to one anastomosis gastric bypass, 20 years of one anastomosis gastric bypass]. ⁶²	Liu Y...Zhang ZT	36245110	2022
10	Comparison of short- and long-term outcomes of bariatric surgery methods: A retrospective study. ⁶²	Cantay H...Cayci HM	36197162	2022
11	Pathological and oncological outcomes of pylorus-preserving versus conventional distal gastrectomy in early gastric cancer: a systematic review and meta-analysis. ⁶²	Hou S...Ye Y	36153587	2022
12	Comparative Study of Pyloromyotomy and H-M Pyloroplasty in Proximal Gastrectomy for Adenocarcinoma of Esophageal-Gastric Junction. ⁶²	Shi M...Zhu Z	35585422	2022
13	Comparison of gastric-jejunum pouch anastomosis and Billroth-II reconstructions after distal gastrectomy: a propensity score matching analysis. ⁶²	Chen G...Cao Y	36017143	2022
14	Patient Selection in One Anastomosis/Mini Gastric Bypass-an Expert Modified Delphi Consensus. ⁶²	Kermansaravi M...De Luca M	35704259	2022
15	Laparoscopic conversion of omega loop gastric bypass to Roux-en-Y gastric bypass for Barrett's esophagus: case report. ⁶²	Lange UG...Dietrich A	35836240	2022
16	The Role of PARP-1 and NF-κB in Bile-Induced DNA Damage and Oncogenic Profile in Hypopharyngeal Cells. ⁶²	Doukas PG...Judson BL	35791892	2022
17	Bile reflux and bile acids in the progression of gastric intestinal metaplasia. ⁶²	Qu X...Shi Y	35940882	2022
18	Non-Acid Fluid Exposure and Esophageal Squamous Cell Carcinoma. ⁶²	Soroush A...Abrams JA	34236559	2022
19	Double tract-like gastric tube reconstruction decreases the incidences of delayed gastric emptying and bile reflux after esophagectomy: results of a pilot study of an experimental technique. ⁶²	Fujimoto D...Kobayashi H	35129627	2022
20	Comparison between laparoscopic uncut Roux-en-Y and Billroth II with Braun anastomosis after distal gastrectomy: A meta-analysis. ⁶²	Jiao YJ...Cai H	35979420	2022
21	Laparoscopic Fundoplication Using the Excluded Stomach as Novel Management Option for Refractory Bile Reflux Following One Anastomosis Gastric Bypass (OAGB). ⁶²	Bhatia M...El-Hasanii S	35414009	2022
22	Conversion of One Anastomosis Gastric Bypass to Roux-en-Y Gastric Bypass: Results of a Retrospective Multicenter Study. ⁶²	Antonopulos C...Msika S	35212908	2022
23	Once in a Bile - the Incidence of Bile Reflux Post-Bariatric Surgery. ⁶²	Eldredge TA...Shenfine J	35226339	2022
24	Bile Reflux After Single Anastomosis Duodenal-Ileal Bypass with Sleeve (SADI-S): a Meta-analysis of 2,029 Patients. ⁶²	Portela R...Ghanem OM	35137290	2022
25	One-stage conversion of laparoscopic adjustable gastric banding to laparoscopic 1-anastomosis gastric bypass: a single-center experience on 1,000 patients at 5 years of follow-up. ⁶²	Soprani A...Carandina S	35246392	2022
26	Bile Acid-Microbiome Interaction Promotes Gastric Carcinogenesis. ⁶²	Wang S...Jia W	35285172	2022
27	Noxious Combination of Tobacco Smoke Nitrosamines with Bile, Deoxycholic Acid, Promotes Hypopharyngeal Squamous Cell Carcinoma, via NFκB, In Vivo. ⁶²	Vageli DP...Judson BL	35502554	2022
28	Emerging Adults Carrying a CDH1 Pathogenic or Likely Pathogenic Variant Face Diet and Lifestyle Challenges after Total Gastrectomy. ⁶²	Liu Y...Lopez R	34968751	2022
29	Endoscopic features and clinical importance of autoimmune gastritis. ⁶²	Kamada T...Haruma K	34674318	2022
30	Roles and action mechanisms of bile acid-induced gastric intestinal metaplasia: a review. ⁶²	He Q...Jiang K	35379788	2022
31	Comparison of the Clinical Outcomes of Reconstruction Methods After Distal Gastrectomy: A Systematic Review and Meta-Analysis Based on Randomized Controlled Trials. ⁶²	Min JS...Jeong SH	35534446	2022
32	A laparoscopic one anastomosis gastric bypass with wrapping versus nonwrapping fundus of the excluded part of the stomach to treat obese patients (FundoRingOAGB trial): study protocol for a randomized controlled trial. ⁶²	Ospanov O...Mustafin A	35392958	2022
33	A Modified Billroth-II with Braun Anastomosis in Totally Laparoscopic Distal Gastrectomy: Initial Experience Compared with Roux-en-Y Anastomosis. ⁶²	Yalikun A...Zang L	34994886	2022
34	ASO Author Reflections: Totally Laparoscopic Distal Gastrectomy with Modified Billroth-II with Braun Reconstruction Could Be Technically Feasible and Effective in Preventing Bile Reflux. ⁶²	Yalikun A...Zang L	34994891	2022
35	A New Analysis for Old Problem of Bile Reflux. ⁶²	Yao C...Lv J	35362459	2022
36	Proximal vs. Total Gastrectomy: Is There a Difference in Quality of Life for Patients? ⁶²	Irfan A...Duncan M	35448929	2022
37	Post-cholecystectomy bile reflux gastritis: Prevalence, risk factors, and clinical characteristics. ⁶²	Othman AA...Abdelrahman AA	35469484	2022
38	Comparison between Roux-en-Y gastrojejunostomy and Billroth-II with Braun anastomosis following partial gastrectomy: A randomized controlled trial. ⁶²	Shishegar A...Fathi F	35495374	2022
39	Symptom resolution of bile reflux gastritis after transoral gastric outlet reduction in a patient with Billroth II anastomosis. ⁶²	Tejedor-Tejada J...Nieto J	34727702	2022
40	Clinical significance of post-operative bile reflux gastritis. ⁶²	Ho KY	35355678	2022
41	[Comparison of clinical efficacy and quality of life between uncut Roux-en-Y and Billroth II with Braun anastomosis in laparoscopic distal gastrectomy for gastric cancer]. ⁶²	Ye XS...Zhao YL	35176829	2022
42	Pyloric Incompetence Associated with Helicobactor pylori Infection and Correlated to the Severity of Atrophic Gastritis. ⁶²	Sakaguchi T...Isomoto H	35328125	2022
43	Techniques for reconstruction after distal gastrectomy for cancer: updated network meta-analysis of randomized controlled trials. ⁶²	Lombardo F...Bona D	35094151	2022
44	Laparoscopic Fundoplication Using the Excluded Stomach as a Novel Management Option for Refractory Bile Reflux Following One Anastomosis Gastric Bypass (OAGB). ⁶²	Werapitiya SB...Coulson TR	34817792	2022
45	Conversion from one-anastomosis gastric bypass to Roux-en-Y gastric bypass: when and why-a single-center experience of all consecutive OAGB procedures. ⁶²	Jedamzik J...Prager G	34794865	2022
46	Evaluation of esophageal pathology in a group of patients 2 years after one-anastomosis gastric bypass (OAGB) - Cohort study. ⁶²	Szymanski M...Proczko-Stepaniak M	34922847	2022
47	Laparoscopic Banded One Anastomosis Gastric Bypass: A Single-Center Series. ⁶²	Campanelli M...Gentileschi P	35132363	2022
48	Spade-Shaped Anastomosis after Laparoscopic Proximal Gastrectomy Using Double Suture Anchoring between the Posterior Wall of the Esophagus and the Anterior Wall of the Stomach (SPADE Operation): A Case Series. ⁶²	Park SH...Kim YW	35053541	2022
49	The Oxidative Damage and Inflammation Mechanisms in GERD-Induced Barrett's Esophagus. ⁶²	Han D...Zhang C	35721515	2022
50	Surgery for Hereditary Diffuse Gastric Cancer: Long-Term Outcomes. ⁶²	Forrester JD...Norton JA	35158993	2022

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Genes for Bile Reflux

Genes related to Bile Reflux (0 elite genes):

(show all 18)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	12.03	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
2	CCK	Cholecystokinin	Protein Coding	11.21	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	2184521 1713673
3	TFF1	Trefoil Factor 1	Protein Coding	10.54	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	16341482
4	ATP4A	ATPase H+/K+ Transporting Subunit Alpha	Protein Coding	7.25	DISEASES inferred ¹⁴
5	ATP12A	ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit	Protein Coding	7.24	DISEASES inferred ¹⁴
6	CDX2	Caudal Type Homeobox 2	Protein Coding	6.5	DISEASES inferred ¹⁴
7	GAST	Gastrin	Protein Coding	6.32	DISEASES inferred ¹⁴
8	CDX1	Caudal Type Homeobox 1	Protein Coding	5.97	DISEASES inferred ¹⁴
9	GPBAR1	G Protein-Coupled Bile Acid Receptor 1	Protein Coding	5.85	DISEASES inferred ¹⁴
10	NR1H4	Nuclear Receptor Subfamily 1 Group H Member 4	Protein Coding	5.71	DISEASES inferred ¹⁴
11	ZNF333	Zinc Finger Protein 333	Protein Coding	5.5	DISEASES inferred ¹⁴
12	EPC2	Enhancer Of Polycomb Homolog 2	Protein Coding	5.34	DISEASES inferred ¹⁴
13	PTGS2	Prostaglandin-Endoperoxide Synthase 2	Protein Coding	5.3	DISEASES inferred ¹⁴
14	ALB	Albumin	Protein Coding	5.12	DISEASES inferred ¹⁴
15	MUC5AC	Mucin 5AC, Oligomeric Mucus/Gel-Forming	Protein Coding	5.05	DISEASES inferred ¹⁴
16	LAT2	Linker For Activation Of T Cells Family Member 2	Protein Coding	5	DISEASES inferred ¹⁴
17	MIR92A1	MicroRNA 92a-1	RNA Gene	4.95	DISEASES inferred ¹⁴
18	S100A8	S100 Calcium Binding Protein A8	Protein Coding	4.92	DISEASES inferred ¹⁴

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Variations for Bile Reflux

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Expression for Bile Reflux

Search GEO for disease gene expression data for Bile Reflux.

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Pathways for Bile Reflux

Pathways related to Bile Reflux according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Gastrin signaling pathway ⁷⁴	11.18	STAT3 PTGS2 GAST
2	Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers ⁶⁵	11.05	STAT3 CDX2 CDX1 ALB

Sources

GO Terms for Bile Reflux

Biological processes related to Bile Reflux according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of somitogenesis	GO:0014807	9.46	CDX2 CDX1
2	embryo development	GO:0009790	9.26	CDX2 CDX1
3	cellular response to bile acid	GO:1903413	9.26	NR1H4 GPBAR1
4	positive regulation of metalloendopeptidase activity	GO:1904685	8.8	STAT3 MIR92A1

Molecular functions related to Bile Reflux according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	P-type sodium:potassium-exchanging transporter activity	GO:0005391	9.56	ATP4A ATP12A
2	P-type potassium:proton transporter activity	GO:0008900	9.26	ATP4A ATP12A
3	P-type potassium transmembrane transporter activity	GO:0008556	9.16	ATP4A ATP12A
4	bile acid receptor activity	GO:0038181	8.92	NR1H4 GPBAR1

Sources

Sources for Bile Reflux

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: BLR002 MIFTS: 36	Bile Reflux Categories: Gastrointestinal diseases, Liver diseases	Data Licensing For inquiries, contact: [email protected]
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