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MCID: BLR002
MIFTS: 36

Bile Reflux

Categories: Gastrointestinal diseases, Liver diseases
Genes Tissues Related diseases Publications Drugs
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Aliases & Classifications for Bile Reflux

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MalaCards integrated aliases for Bile Reflux:

Name: Bile Reflux 12 56 45 15 17 74

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases Liver diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:12237
MeSH 45 D001655
UMLS 74 C0005403
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Summaries for Bile Reflux

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MalaCards based summary : Bile Reflux is related to peptic esophagitis and gastric ulcer. An important gene associated with Bile Reflux is CCK (Cholecystokinin). The drugs Domperidone and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include testes, pancreas and skin, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

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Related Diseases for Bile Reflux

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Diseases related to Bile Reflux via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
# Related Disease Score Top Affiliating Genes
1 peptic esophagitis 30.5 ATP12A ATP4A
2 gastric ulcer 30.3 PTGS2 TFF1
3 barrett esophagus 30.0 CDX2 PTGS2 TFF1
4 gastroesophageal reflux 29.9 CCK CDX2 PTGS2
5 dyspepsia 29.8 CCK PTGS2
6 peptic ulcer disease 29.8 ATP4A PTGS2
7 gastritis 10.7
8 degos 'en cocarde' erythrokeratoderma 10.5
9 pancreatitis 10.4
10 fungal esophagitis 10.2 ATP12A ATP4A
11 diclofenac allergy 10.2 ATP12A ATP4A
12 gastroduodenal crohn's disease 10.2 ATP12A ATP4A
13 neonatal candidiasis 10.2 ATP12A ATP4A
14 squamous papillomatosis 10.2 ATP12A ATP4A
15 toxic megacolon 10.2 ATP12A ATP4A
16 aspiration pneumonitis 10.2 ATP12A ATP4A
17 gastrointestinal neuroendocrine benign tumor 10.2 ATP12A ATP4A
18 gastric antral vascular ectasia 10.2 ATP12A ATP4A
19 granulomatous gastritis 10.2 ATP12A ATP4A
20 esophageal candidiasis 10.2 ATP12A ATP4A
21 gastric neuroendocrine neoplasm 10.2 ATP12A ATP4A
22 acute laryngitis 10.2 ATP12A ATP4A
23 laryngitis 10.2 ATP12A ATP4A
24 helicobacter pylori infection 10.2
25 esophagitis 10.2
26 duodenal ulcer 10.2
27 duodenitis 10.2 ATP12A ATP4A
28 rumination disorder 10.2 ATP12A ATP4A
29 congenital disorder of deglycosylation 10.2 ATP12A ATP4A
30 bladder calculus 10.2 ATP12A ATP4A
31 ischemic neuropathy 10.2 ATP12A ATP4A
32 capillary disease 10.2 ATP12A ATP4A
33 dyskinesia of esophagus 10.2 ATP12A ATP4A
34 hernia, hiatus 10.2 ATP12A ATP4A
35 anismus 10.2 ATP12A ATP4A
36 postsurgical hypothyroidism 10.2 ATP12A ATP4A
37 lymphocytic colitis 10.2 ATP12A ATP4A
38 esophageal atresia/tracheoesophageal fistula 10.2 ATP12A ATP4A
39 clostridium difficile colitis 10.2 ATP12A ATP4A
40 diarrhea 1, secretory chloride, congenital 10.2 ATP12A ATP4A
41 esophagitis, eosinophilic, 1 10.2 ATP12A ATP4A
42 microscopic colitis 10.2 ATP12A ATP4A
43 laryngeal tuberculosis 10.2 ATP12A ATP4A
44 chronic laryngitis 10.2 ATP12A ATP4A
45 eosinophilic gastritis 10.2 ATP12A ATP4A
46 chronic intestinal vascular insufficiency 10.2 ATP12A ATP4A
47 jejunoileitis 10.2 ATP12A ATP4A
48 esophageal varix 10.2 ATP12A ATP4A
49 gastric lymphoma 10.2 ATP12A ATP4A
50 acute pancreatitis 10.2

Graphical network of the top 20 diseases related to Bile Reflux:



Diseases related to Bile Reflux
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Symptoms & Phenotypes for Bile Reflux

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MGI Mouse Phenotypes related to Bile Reflux:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.7 ATP12A ATP4A CDX1 CDX2 PCSK5 PTGS2
2 endocrine/exocrine gland MP:0005379 9.43 ATP4A CCK CDX1 CDX2 PCSK5 PTGS2
3 neoplasm MP:0002006 8.92 ATP4A CDX2 PTGS2 TFF1
Sources

Drugs & Therapeutics for Bile Reflux

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Drugs for Bile Reflux (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 58)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Domperidone Approved, Investigational, Vet_approved Phase 4 57808-66-9 3151
2
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
3
Famotidine Approved Phase 4 76824-35-6 3325
4
Histamine Approved, Investigational Phase 4 51-45-6 774
5
Ranitidine Approved Phase 4 66357-59-3, 66357-35-5 3001055
6
Nizatidine Approved Phase 4 76963-41-2 3033637
7
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
8
Pantoprazole Approved Phase 4 102625-70-7 4679
9
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 161973-10-0, 119141-88-7 9568614 4594
10
Omeprazole Approved, Investigational, Vet_approved Phase 4,Not Applicable 73590-58-6 4594
11
Sodium Citrate Approved, Investigational Phase 4 68-04-2
12
Metoclopramide Approved, Investigational Phase 4 364-62-5 4168
13
Cimetidine Approved, Investigational Phase 4 51481-61-9 2756
14
Dexlansoprazole Approved, Investigational Phase 4 138530-94-6, 103577-45-3 9578005
15
Rabeprazole Approved, Investigational Phase 4 117976-89-3 5029
16
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
17
Lafutidine Investigational Phase 4 118288-08-7 5282136
18 Neurotransmitter Agents Phase 4,Phase 2
19 Histamine H2 Antagonists Phase 4
20 Gastrointestinal Agents Phase 4,Not Applicable
21 Bismuth tripotassium dicitrate Phase 4
22
Histamine Phosphate Phase 4 51-74-1 65513
23 Dopamine Antagonists Phase 4
24 Dopamine D2 Receptor Antagonists Phase 4
25 Peripheral Nervous System Agents Phase 4
26 Histamine Antagonists Phase 4
27 Cytochrome P-450 Enzyme Inhibitors Phase 4
28 Ranitidine bismuth citrate Phase 4
29 Proton Pump Inhibitors Phase 4,Not Applicable
30 Anesthetics Phase 4
31 Anti-Ulcer Agents Phase 4,Not Applicable
32 Citrate Phase 4
33 Antiemetics Phase 4
34 Antacids Phase 4,Not Applicable
35 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
36 Dopamine Agents Phase 4
37 Autonomic Agents Phase 4
38
Bismuth Phase 4 7440-69-9 105143 16682734
39
Somatostatin Approved, Investigational Phase 2 38916-34-6, 51110-01-1 53481605
40
lanreotide Approved Phase 2 108736-35-2
41
leucovorin Approved Phase 1, Phase 2 58-05-9 143 6006
42
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 59-30-3 6037
43
Imidacloprid Vet_approved Phase 2 105827-78-9 86418
44 Hormones Phase 2
45 Angiopeptin Phase 2
46 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
47 Hormone Antagonists Phase 2
48 Cholinergic Agents Phase 2
49 Vitamin B9 Phase 1, Phase 2
50 Vitamin B Complex Phase 1, Phase 2

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 Prophylaxis for Aspiration of Gastric Contents. Completed NCT02703896 Phase 4 Drug either PPIS or H2RA and prokinetics
2 Comparison Study for Bile Reflux and Gastric Stasis in Patients After Distal Gastrectomy Withdrawn NCT00622804 Phase 3
3 Resolving Bile Reflux by Lanreotide in Patients With Roux-en-Y Gastrojejunostomy Unknown status NCT02054637 Phase 2 Lanreotide
4 The Advantages and Disadvantages Between Uncut Roux-en-Y Reconstruction and Billroth II Reconstruction After Laparoscopy-assisted Distal Gastrectomy for Gastric Unknown status NCT02694081 Phase 2
5 Jianpi Huoxue Recipe in Treating Gastric Premalignant Lesion Not yet recruiting NCT03823248 Phase 1, Phase 2 MoLuoDan;Sanchi powder;Folic Acid Tablet;MoLuoDan simulation;Sanchi powder simulation;Folic Acid Tablet simulation
6 The Revolutions of Helicobacter Pylori Infection, Bacterial Density, and Histological Features After Antrectomy Unknown status NCT00441831
7 Endoscopic Tri-Modal Imaging to Distinguish Functional Dyspepsia From Reflux Disease Completed NCT02685150 Not Applicable Omeprazole
8 Revisional Surgery After 925 OAGB[One Anastomosis Gastric Bypass] Operations Retrospective Cohort Study of the UK MGB/OAGB Collaborative Group. Completed NCT03859596
9 Omega Loop Gastric Bypass With And Without Anti-Reflux Sutures Recruiting NCT03097887 Not Applicable
10 Comparison of Mini Gastric Bypass and Roux-en-Y Gastric Bypass Recruiting NCT02882685 Not Applicable
11 the Laparoscopic and Endoscopic Cooperative Surgery of Gastrointestinal Stromal Tumor Recruiting NCT02763748 Not Applicable
12 Three M Study (Malabsorption, Microbiota, Mini-Gastric Bypass) Recruiting NCT03412149 Not Applicable
13 Laparoscopic Endoscopic Cooperative Surgery in the Treatment of Gastric Stromal Tumors Recruiting NCT03601234 Not Applicable
14 Uncut Roux-en-Y vs Roux-en-Y Recruiting NCT03349398 Not Applicable
15 Endoscopic Complications After Gastric Bypass Active, not recruiting NCT03532646 Not Applicable
16 Comparison of Open Laparoscopic and Robotic Surgery in Gastric Cancer Resection. Not yet recruiting NCT03447106 Not Applicable
17 Comparative Study of Antiperistaltic vs Isoperistaltic Billroth II + Braun Anastomosis for Postoperative Reflux Not yet recruiting NCT03372681 Not Applicable

Search NIH Clinical Center for Bile Reflux

Cochrane evidence based reviews: bile reflux

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Genetic Tests for Bile Reflux

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Anatomical Context for Bile Reflux

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MalaCards organs/tissues related to Bile Reflux:

42
Testes, Pancreas, Skin, Liver, Colon
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Publications for Bile Reflux

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Articles related to Bile Reflux:

(show top 50) (show all 206)
# Title Authors Year
1
Comparison of the Bile Reflux Frequency in One Anastomosis Gastric Bypass and Roux-en-Y Gastric Bypass: a Cohort Study. ( 30767188 )
2019
2
Bile reflux gastritis cystica profunda: A case report and literature review. ( 31027092 )
2019
3
Detecting Bile Reflux-the Enigma of Bariatric Surgery. ( 29230622 )
2018
4
New Causes for the Old Problem of Bile Reflux Gastritis. ( 29505908 )
2018
5
Detecting Bile Reflux-the Enigma of Bariatric Surgery. ( 29671122 )
2018
6
Gastrogastric Fistula: an Unusual Cause for Severe Bile Reflux Following Conversion of Sleeve Gastrectomy to One Anastomosis Gastric Bypass. ( 29728987 )
2018
7
Response to a Letter to the Editor Re: Detecting Bile Reflux-the Enigma of Bariatric Surgery. ( 29744716 )
2018
8
Curcumin prevents the bile reflux-induced NF-κB-related mRNA oncogenic phenotype, in human hypopharyngeal cells. ( 29911313 )
2018
9
A study on the roles of Helicobacter pylori in bile reflux gastritis and gastric cancer. ( 30003734 )
2018
10
Remnant gastropathy due to bile reflux after Roux-en-Y gastric bypass: a unique cause of abdominal pain and successful treatment with ursodiol. ( 28799115 )
2017
11
Laparoscopic conversion of one anastomosis gastric bypass/mini gastric bypass to Roux-en-Y gastric bypass for bile reflux gastritis. ( 27825579 )
2017
12
Conversion of one anastomosis gastric bypass/mini gastric bypass to Roux-en-Y gastric bypass for bile reflux gastritis after failed Braun jejunojejunostomy. ( 27986575 )
2017
13
Quality of life and impact of bile reflux after retro colic retro gastric gastrojejunostomy in Whipple surgery. ( 28109253 )
2017
14
Does Braun Anastomosis Have an Impact on the Incidence of Delayed Gastric Emptying and the Extent of Intragastric Bile Reflux Following Pancreatoduodenectomy? - A Randomized Controlled Study. ( 28132059 )
2017
15
Bile Reflux Scintigraphy After Mini-Gastric Bypass. ( 28214959 )
2017
16
Correlation Between Bile Reflux Gastritis and Biliary Excreted Contrast Media in the Stomach. ( 28240637 )
2017
17
Bile reflux of the remnant stomach following Roux-en-Y gastric bypass: an etiology of chronic abdominal pain treated with remnant gastrectomy. ( 28576682 )
2017
18
Laparoscopic Conversion of One Anastomosis Gastric Bypass to Roux-en-Y Gastric Bypass for Chronic Bile Reflux. ( 26746224 )
2016
19
Rabeprazole is effective for bile reflux oesophagitis after total gastrectomy in a rat model. ( 25685608 )
2015
20
Evaluation of bile reflux in HIDA images based on fluid mechanics. ( 25754361 )
2015
21
Clinical significance of bile reflux into the pancreatic duct without pancreaticobiliary maljunction assessed by intraoperative cholangiography. ( 25756368 )
2015
22
Dietary and Medicinal Herbal Recommendation for Management of Primary Bile Reflux Gastritis in Traditional Persian Medicine. ( 26587489 )
2015
23
Does Bile Reflux Influence the Progression of Barrett's Esophagus to Adenocarcinoma? (Gastroenterology 2013;145:1300-1311). ( 24466454 )
2014
24
Uncut Roux-en-Y Reconstruction after Laparoscopic Distal Gastrectomy Can Be a Favorable Method in Terms of Gastritis, Bile Reflux, and Gastric Residue. ( 25580354 )
2014
25
Resolving bile reflux by lanreotide in patients with Roux-en-Y gastrojejunostomy. ( 25682623 )
2014
26
Management of bile reflux. ( 23961269 )
2013
27
The effects of chronic bile reflux on the gastric mucosa of rats. ( 24226718 )
2013
28
Bridging across the ampulla with metal stents: evidences for intestinal bile reflux. ( 24719925 )
2013
29
Histological features of the gastric mucosa in children with primary bile reflux gastritis. ( 22289498 )
2012
30
Opie's hypothesis revisited: acute pancreatitis due to bile reflux into the pancreas. ( 22487472 )
2012
31
A modified laparoscopic esophagogastric dissociation for severe bile reflux in a neurologically impaired child. ( 23084208 )
2012
32
The histological and immunohistochemical aspects of bile reflux in patients with gastroesophageal reflux disease. ( 21822428 )
2011
33
Emerging concepts of bile reflux in the constellation of gastroesophageal reflux disease. ( 19756880 )
2010
34
Ketamine suppresses LPS-induced bile reflux and gastric bleeding in the rat. ( 20065760 )
2010
35
The role of acid and bile reflux in oesophagitis and Barrett's metaplasia. ( 20298181 )
2010
36
Rabeprazole combined with hydrotalcite is effective for patients with bile reflux gastritis after cholecystectomy. ( 20352149 )
2010
37
Laparoscopic revision of Roux-en-Y gastric bypass for dysphagia and bile reflux. ( 20870186 )
2010
38
Bile reflux after Roux-en-Y gastric bypass: an unrecognized cause of postoperative pain. ( 19095503 )
2009
39
Prevalence of bile reflux in gastroesophageal reflux disease patients not responsive to proton pump inhibitors. ( 19140233 )
2009
40
The key event of acute pancreatitis: pancreatic duct obstruction and bile reflux, not a single one can be omitted. ( 19147295 )
2009
41
Comment on: Bile reflux after Roux-en-Y gastric bypass: an unrecognized cause of postoperative pain (Swartz DE, et al. 2009;5:27-30). ( 19306824 )
2009
42
The significance of histological evidence of bile reflux gastropathy in patients with gastro-esophageal reflux disease. ( 19478703 )
2009
43
Effect of cholecystectomy on gastric and esophageal bile reflux in patients with upper gastrointestinal symptoms. ( 17939040 )
2008
44
Comments on the publication "effect of pyloric drainage procedures on gastric passage and bile reflux after esophagectomy with gastric conduit reconstruction by Palmes et al.". ( 17992536 )
2008
45
Bile reflux index after therapeutic biliary procedures. ( 18267026 )
2008
46
Acid and bile reflux in erosive reflux disease, non-erosive reflux disease and Barrett's esophagus. ( 18613384 )
2008
47
Role of bile reflux and Helicobacter pylori infection on inflammation of gastric remnant after distal gastrectomy. ( 18959592 )
2008
48
Effect of pyloric drainage procedures on gastric passage and bile reflux after esophagectomy with gastric conduit reconstruction. ( 17216285 )
2007
49
Bile reflux in the esophagus demonstrated by HIDA scintigraphy. ( 17314604 )
2007
50
Do acid and bile reflux into the esophagus simultaneously? Temporal relationship between duodenogastro-esophageal reflux and esophageal pH. ( 17445043 )
2007
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Variations for Bile Reflux

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Expression for Bile Reflux

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Search GEO for disease gene expression data for Bile Reflux.
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Pathways for Bile Reflux

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GO Terms for Bile Reflux

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Biological processes related to Bile Reflux according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 memory GO:0007613 9.49 CCK PTGS2
2 pattern specification process GO:0007389 9.48 CDX1 CDX2
3 embryo implantation GO:0007566 9.46 PCSK5 PTGS2
4 potassium ion import across plasma membrane GO:1990573 9.43 ATP12A ATP4A
5 ATP hydrolysis coupled proton transport GO:0015991 9.4 ATP12A ATP4A
6 cellular sodium ion homeostasis GO:0006883 9.37 ATP12A ATP4A
7 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.32 ATP12A ATP4A
8 cellular potassium ion homeostasis GO:0030007 9.26 ATP12A ATP4A
9 sodium ion export across plasma membrane GO:0036376 9.16 ATP12A ATP4A
10 anterior/posterior pattern specification GO:0009952 9.13 CDX1 CDX2 PCSK5
11 regulation of somitogenesis GO:0014807 8.62 CDX1 CDX2

Molecular functions related to Bile Reflux according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 methyl-CpG binding GO:0008327 9.16 CDX1 CDX2
2 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
3 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A
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Sources for Bile Reflux

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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