MCID: BLR002
MIFTS: 36

Bile Reflux

Categories: Gastrointestinal diseases, Liver diseases
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Aliases & Classifications for Bile Reflux

MalaCards integrated aliases for Bile Reflux:

Name: Bile Reflux 11 53 43 14 16 71

Classifications:



External Ids:

Disease Ontology 11 DOID:12237
MeSH 43 D001655
UMLS 71 C0005403

Summaries for Bile Reflux

Disease Ontology: 11 A biliary tract disease characterized by the flow of bile up into the stomach and/or esophagus.

MalaCards based summary: Bile Reflux is related to gastritis and duodenal ulcer. An important gene associated with Bile Reflux is STAT3 (Signal Transducer And Activator Of Transcription 3), and among its related pathways/superpathways are Gastrin signaling pathway and Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers. The drugs Lanreotide and Esomeprazole have been mentioned in the context of this disorder. Affiliated tissues include tongue, liver and pancreas, and related phenotypes are Reduced mammosphere formation and homeostasis/metabolism

Related Diseases for Bile Reflux

Diseases related to Bile Reflux via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 267)
# Related Disease Score Top Affiliating Genes
1 gastritis 31.6 S100A8 PTGS2 GAST CDX2 ATP4A
2 duodenal ulcer 30.6 S100A8 GAST CCK
3 gastric ulcer 30.4 TFF1 S100A8 PTGS2 GAST ATP12A
4 postcholecystectomy syndrome 30.2 GAST CCK
5 duodenogastric reflux 30.2 MIR92A1 GPBAR1 GAST CCK ATP4A ATP12A
6 gastroesophageal reflux 30.2 S100A8 PTGS2 GAST CDX2 CCK ATP4A
7 esophagus adenocarcinoma 30.2 PTGS2 CDX2 ATP4A ATP12A
8 biliary dyskinesia 30.2 CCK ATP4A ATP12A
9 pernicious anemia 30.1 GAST ATP4A ATP12A
10 gallbladder disease 29.9 NR1H4 CCK ALB
11 cholangitis 29.9 NR1H4 GPBAR1 ALB
12 fungal infectious disease 29.8 STAT3 ATP4A ATP12A ALB
13 gastrointestinal system disease 29.8 S100A8 MIR92A1 GAST CCK
14 cardia cancer 29.7 S100A8 GAST ATP4A ATP12A
15 cholelithiasis 29.7 NR1H4 GAST CCK ALB
16 barrett esophagus 29.5 TFF1 S100A8 PTGS2 NR1H4 MUC5AC GAST
17 cholecystitis 29.5 TFF1 S100A8 MUC5AC CCK ALB
18 microinvasive gastric cancer 29.4 S100A8 MUC5AC GAST CDX2 ATP4A ATP12A
19 peptic ulcer disease 29.3 S100A8 PTGS2 MUC5AC GAST CCK ATP4A
20 esophageal disease 29.3 MIR92A1 ATP4A ATP12A ALB
21 peptic esophagitis 29.3 S100A8 PTGS2 LAT2 GAST CDX2 ATP4A
22 esophageal cancer 28.9 STAT3 PTGS2 MIR92A1 CDX2 ATP4A ATP12A
23 gastric cancer 28.8 TFF1 STAT3 S100A8 PTGS2 MUC5AC GAST
24 atrophic gastritis 28.8 TFF1 S100A8 PTGS2 MIR92A1 GAST CDX2
25 cystic fibrosis 28.7 STAT3 S100A8 PTGS2 MUC5AC CCK ATP12A
26 pancreatic cancer 28.3 TFF1 STAT3 PTGS2 MUC5AC MIR92A1 GAST
27 esophagitis 10.5
28 helicobacter pylori infection 10.5
29 pancreatic vasoactive intestinal peptide producing tumor 10.4 ATP4A ATP12A
30 acquired laryngomalacia 10.4 ATP4A ATP12A
31 scalp dermatosis 10.4 ATP4A ATP12A
32 acquired gastric outlet stenosis 10.3 ATP4A ATP12A
33 lingual goiter 10.3 ATP4A ATP12A
34 esophageal diverticulosis 10.3 ATP4A ATP12A
35 benign shuddering attacks 10.3 ATP4A ATP12A
36 persistent moderate asthma 10.3 ATP4A ATP12A
37 viral esophagitis 10.3 ATP4A ATP12A
38 cervix erosion 10.3 ATP4A ATP12A
39 bacterial esophagitis 10.3 ATP4A ATP12A
40 angiodysplasia of intestine 10.3 ATP4A ATP12A
41 angiodysplasia 10.3 ATP4A ATP12A
42 benzylpenicillin allergy 10.3 ATP4A ATP12A
43 penicillin allergy 10.3 ATP4A ATP12A
44 fungal esophagitis 10.3 ATP4A ATP12A
45 emphysematous cholecystitis 10.3 ATP4A ATP12A
46 afferent loop syndrome 10.3 ATP4A ATP12A
47 laryngeal tuberculosis 10.3 ATP4A ATP12A
48 gastrojejunal ulcer 10.3 ATP4A ATP12A
49 cefuroxime allergy 10.3 ATP4A ATP12A
50 median arcuate ligament syndrome 10.3 ATP4A ATP12A

Graphical network of the top 20 diseases related to Bile Reflux:



Diseases related to Bile Reflux

Symptoms & Phenotypes for Bile Reflux

GenomeRNAi Phenotypes related to Bile Reflux according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.1 ALB ATP4A MUC5AC NR1H4 PTGS2 STAT3

MGI Mouse Phenotypes related to Bile Reflux:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10 ALB ATP12A ATP4A CCK CDX2 EPC2
2 neoplasm MP:0002006 9.86 ALB ATP4A CDX2 GAST NR1H4 PTGS2
3 endocrine/exocrine gland MP:0005379 9.65 ALB ATP4A CCK CDX1 CDX2 GAST
4 digestive/alimentary MP:0005381 9.36 ALB ATP12A ATP4A CDX1 CDX2 GAST

Drugs & Therapeutics for Bile Reflux

Drugs for Bile Reflux (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lanreotide Approved Phase 2 108736-35-2 71349 6918011
2
Esomeprazole Approved, Investigational, Vet_approved 73590-58-6, 119141-88-7 9568614 4594
3
bilirubin 635-65-4 5280352
4 Anti-Ulcer Agents
5 Antacids
6 Proton Pump Inhibitors
7 Gastrointestinal Agents
8 Bile Acids and Salts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase III Study on Comparison for Bile Reflux and Gastric Stasis in Patients With Gastric Cancer After Distal Gastrectomy Withdrawn NCT00622804 Phase 3
2 Resolving Bile Reflux by Lanreotide in Patients With Roux-en-Y Gastrojejunostomy Unknown status NCT02054637 Phase 2 Lanreotide
3 Prospective, Randomized, Controlled Trial of Omega Loop Gastric Bypass With and Without Anti-reflux Sutures - a Pilot Study Unknown status NCT03097887
4 The Revolutions of Helicobacter Pylori Infection, Bacterial Density, and Histological Features After Antrectomy Unknown status NCT00441831
5 Bile Reflux Gastropathy: Prevalence and Risk Factors After Therapeutic Biliary Interventions: A Retrospective Cohort Study Completed NCT05131802
6 Study on the Effect of Bile Reflux on Gastric Cancer and Its Precancerous Lesions: a Multiple Center, Cross-sectional Study. Completed NCT03976739
7 The Role of Endoscopic Tri-Modal Imaging in Distinguishing Functional Dyspepsia From Reflux Disease Completed NCT02685150 Omeprazole
8 Evaluation of Biliary Reflux After Mini-gastric Bypass With Using the Biliary Reflux Index Recruiting NCT04845438
9 Associations Among Serum and Gastric Juice Bile Acid Profile, Bile Acid-microbiota Cross-talk in Stomach and the Development of Gastric Cancer: A Case-control Study Enrolling by invitation NCT04660058
10 Analysing the Link Between Tongue Signs and Bile Reflux by Artificial Intelligence Not yet recruiting NCT05369572

Search NIH Clinical Center for Bile Reflux

Cochrane evidence based reviews: bile reflux

Genetic Tests for Bile Reflux

Anatomical Context for Bile Reflux

Organs/tissues related to Bile Reflux:

MalaCards : Tongue, Liver, Pancreas, Colon, Endothelial, Bone

Publications for Bile Reflux

Articles related to Bile Reflux:

(show top 50) (show all 974)
# Title Authors PMID Year
1
Interleukin-8, cyclo-oxygenase-2, and trefoil factor family 1 gene expression and their association with Helicobacter pylori infection in the remnant stomach. 53 62
16341482 2005
2
The effect of the CCK receptor antagonist CR 1409 on bile reflux pancreatitis in the opossum. 53 62
1713673 1991
3
Pharmacokinetics and clinical application of technetium 99m-labeled hepatobiliary agents. 53 62
2184521 1990
4
Negative correlations between bile reflux gastritis and Helicobacter pylori infection. 62
35840539 2022
5
A Gastrectomy for early-stage gastric cancer patients with or without preserving celiac branches of vagus nerves: A meta-analysis. 62
36379744 2022
6
Effect of hiatus hernia on reflux patterns and mucosal integrity in patients with non-erosive reflux disease. 62
35593218 2022
7
A Single-site Interventional Study on the Contemporary Relevance of Braun Enteroenterostomy After Pancreaticoduodenectomy. 62
36340448 2022
8
A 3-year follow-up study of uncut Roux-en-Y reconstruction: clinical results and outcomes. 62
35380283 2022
9
[From mini gastric bypass to one anastomosis gastric bypass, 20 years of one anastomosis gastric bypass]. 62
36245110 2022
10
Comparison of short- and long-term outcomes of bariatric surgery methods: A retrospective study. 62
36197162 2022
11
Pathological and oncological outcomes of pylorus-preserving versus conventional distal gastrectomy in early gastric cancer: a systematic review and meta-analysis. 62
36153587 2022
12
Comparative Study of Pyloromyotomy and H-M Pyloroplasty in Proximal Gastrectomy for Adenocarcinoma of Esophageal-Gastric Junction. 62
35585422 2022
13
Comparison of gastric-jejunum pouch anastomosis and Billroth-II reconstructions after distal gastrectomy: a propensity score matching analysis. 62
36017143 2022
14
Patient Selection in One Anastomosis/Mini Gastric Bypass-an Expert Modified Delphi Consensus. 62
35704259 2022
15
Laparoscopic conversion of omega loop gastric bypass to Roux-en-Y gastric bypass for Barrett's esophagus: case report. 62
35836240 2022
16
The Role of PARP-1 and NF-κB in Bile-Induced DNA Damage and Oncogenic Profile in Hypopharyngeal Cells. 62
35791892 2022
17
Bile reflux and bile acids in the progression of gastric intestinal metaplasia. 62
35940882 2022
18
Non-Acid Fluid Exposure and Esophageal Squamous Cell Carcinoma. 62
34236559 2022
19
Double tract-like gastric tube reconstruction decreases the incidences of delayed gastric emptying and bile reflux after esophagectomy: results of a pilot study of an experimental technique. 62
35129627 2022
20
Comparison between laparoscopic uncut Roux-en-Y and Billroth II with Braun anastomosis after distal gastrectomy: A meta-analysis. 62
35979420 2022
21
Laparoscopic Fundoplication Using the Excluded Stomach as Novel Management Option for Refractory Bile Reflux Following One Anastomosis Gastric Bypass (OAGB). 62
35414009 2022
22
Conversion of One Anastomosis Gastric Bypass to Roux-en-Y Gastric Bypass: Results of a Retrospective Multicenter Study. 62
35212908 2022
23
Once in a Bile - the Incidence of Bile Reflux Post-Bariatric Surgery. 62
35226339 2022
24
Bile Reflux After Single Anastomosis Duodenal-Ileal Bypass with Sleeve (SADI-S): a Meta-analysis of 2,029 Patients. 62
35137290 2022
25
One-stage conversion of laparoscopic adjustable gastric banding to laparoscopic 1-anastomosis gastric bypass: a single-center experience on 1,000 patients at 5 years of follow-up. 62
35246392 2022
26
Bile Acid-Microbiome Interaction Promotes Gastric Carcinogenesis. 62
35285172 2022
27
Noxious Combination of Tobacco Smoke Nitrosamines with Bile, Deoxycholic Acid, Promotes Hypopharyngeal Squamous Cell Carcinoma, via NFκB, In Vivo. 62
35502554 2022
28
Emerging Adults Carrying a CDH1 Pathogenic or Likely Pathogenic Variant Face Diet and Lifestyle Challenges after Total Gastrectomy. 62
34968751 2022
29
Endoscopic features and clinical importance of autoimmune gastritis. 62
34674318 2022
30
Roles and action mechanisms of bile acid-induced gastric intestinal metaplasia: a review. 62
35379788 2022
31
Comparison of the Clinical Outcomes of Reconstruction Methods After Distal Gastrectomy: A Systematic Review and Meta-Analysis Based on Randomized Controlled Trials. 62
35534446 2022
32
A laparoscopic one anastomosis gastric bypass with wrapping versus nonwrapping fundus of the excluded part of the stomach to treat obese patients (FundoRingOAGB trial): study protocol for a randomized controlled trial. 62
35392958 2022
33
A Modified Billroth-II with Braun Anastomosis in Totally Laparoscopic Distal Gastrectomy: Initial Experience Compared with Roux-en-Y Anastomosis. 62
34994886 2022
34
ASO Author Reflections: Totally Laparoscopic Distal Gastrectomy with Modified Billroth-II with Braun Reconstruction Could Be Technically Feasible and Effective in Preventing Bile Reflux. 62
34994891 2022
35
A New Analysis for Old Problem of Bile Reflux. 62
35362459 2022
36
Proximal vs. Total Gastrectomy: Is There a Difference in Quality of Life for Patients? 62
35448929 2022
37
Post-cholecystectomy bile reflux gastritis: Prevalence, risk factors, and clinical characteristics. 62
35469484 2022
38
Comparison between Roux-en-Y gastrojejunostomy and Billroth-II with Braun anastomosis following partial gastrectomy: A randomized controlled trial. 62
35495374 2022
39
Symptom resolution of bile reflux gastritis after transoral gastric outlet reduction in a patient with Billroth II anastomosis. 62
34727702 2022
40
Clinical significance of post-operative bile reflux gastritis. 62
35355678 2022
41
[Comparison of clinical efficacy and quality of life between uncut Roux-en-Y and Billroth II with Braun anastomosis in laparoscopic distal gastrectomy for gastric cancer]. 62
35176829 2022
42
Pyloric Incompetence Associated with Helicobactor pylori Infection and Correlated to the Severity of Atrophic Gastritis. 62
35328125 2022
43
Techniques for reconstruction after distal gastrectomy for cancer: updated network meta-analysis of randomized controlled trials. 62
35094151 2022
44
Laparoscopic Fundoplication Using the Excluded Stomach as a Novel Management Option for Refractory Bile Reflux Following One Anastomosis Gastric Bypass (OAGB). 62
34817792 2022
45
Conversion from one-anastomosis gastric bypass to Roux-en-Y gastric bypass: when and why-a single-center experience of all consecutive OAGB procedures. 62
34794865 2022
46
Evaluation of esophageal pathology in a group of patients 2 years after one-anastomosis gastric bypass (OAGB) - Cohort study. 62
34922847 2022
47
Laparoscopic Banded One Anastomosis Gastric Bypass: A Single-Center Series. 62
35132363 2022
48
Spade-Shaped Anastomosis after Laparoscopic Proximal Gastrectomy Using Double Suture Anchoring between the Posterior Wall of the Esophagus and the Anterior Wall of the Stomach (SPADE Operation): A Case Series. 62
35053541 2022
49
The Oxidative Damage and Inflammation Mechanisms in GERD-Induced Barrett's Esophagus. 62
35721515 2022
50
Surgery for Hereditary Diffuse Gastric Cancer: Long-Term Outcomes. 62
35158993 2022

Variations for Bile Reflux

Expression for Bile Reflux

Search GEO for disease gene expression data for Bile Reflux.

Pathways for Bile Reflux

Pathways related to Bile Reflux according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.18 STAT3 PTGS2 GAST
2 11.05 STAT3 CDX2 CDX1 ALB

GO Terms for Bile Reflux

Biological processes related to Bile Reflux according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of somitogenesis GO:0014807 9.46 CDX2 CDX1
2 embryo development GO:0009790 9.26 CDX2 CDX1
3 cellular response to bile acid GO:1903413 9.26 NR1H4 GPBAR1
4 positive regulation of metalloendopeptidase activity GO:1904685 8.8 STAT3 MIR92A1

Molecular functions related to Bile Reflux according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 P-type sodium:potassium-exchanging transporter activity GO:0005391 9.56 ATP4A ATP12A
2 P-type potassium:proton transporter activity GO:0008900 9.26 ATP4A ATP12A
3 P-type potassium transmembrane transporter activity GO:0008556 9.16 ATP4A ATP12A
4 bile acid receptor activity GO:0038181 8.92 NR1H4 GPBAR1

Sources for Bile Reflux

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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