MCID: BLR001
MIFTS: 51

Biliary Atresia

Categories: Gastrointestinal diseases, Liver diseases, Rare diseases

Aliases & Classifications for Biliary Atresia

MalaCards integrated aliases for Biliary Atresia:

Name: Biliary Atresia 12 75 53 37 55 44 15 72
Isolated Atresia of Bile Ducts 53
Non-Syndromic Biliary Atresia 53
Biliary Atresia, Congenital 12
Congenital Biliary Atresia 12
Isolated Biliary Atresia 53
Atresia of Bile Duct 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13608
KEGG 37 H01855
ICD9CM 35 751.61
MeSH 44 D001656
NCIt 50 C34421
SNOMED-CT 68 77480004
ICD10 33 Q44.2
UMLS 72 C0005411

Summaries for Biliary Atresia

KEGG : 37
Biliary atresia (BA) is a congenital, fibro-obliterative obstructive cholangiopathy. It can be a devastating disease in infants invariably leading, if untreated, to cirrhosis, liver failure and death. Patients will be jaundiced and will have pale stools and dark urine. This is due to the inability to excrete conjugated bilirubin into the gastrointestinal tract, which is then excreted into the urine causing its color to darken. The cause of BA is not known with any degree of certainty, though there are a number of hypotheses. One prominent theory regarding the pathogenesis is that bile duct injury is initially caused by a viral infection, and then perpetuated by an autoimmune disorder. Surgical drainage, the only effective intervention, is successful only half of the time. Approximately 80% of patients require one or more liver transplantations with the associated morbidity and mortality issues caused by life-long transplant-related immunosuppression.

MalaCards based summary : Biliary Atresia, also known as isolated atresia of bile ducts, is related to biliary atresia, extrahepatic and cholangitis, and has symptoms including icterus An important gene associated with Biliary Atresia is GPT (Glutamic--Pyruvic Transaminase), and among its related pathways/superpathways are Immune response IFN alpha/beta signaling pathway and NRF2 pathway. The drugs Meloxicam and Anti-Inflammatory Agents have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and testes, and related phenotypes are Reduced mammosphere formation and growth/size/body region

Disease Ontology : 12 A cholestasis characterized by blockage of the ducts that carry bile from the liver to the gallbladder.

NIH Rare Diseases : 53 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 30391DefinitionBiliary atresia is a rare, progressive obliterative cholangiopathy of the extrahepatic bile ducts, occuring in the embryonic/ perinatal period, leading to severe and persistent jaundice and acholic stool with an unfavorable course in the absence of treatment.Visit the Orphanet disease page for more resources.

Wikipedia : 75 Biliary atresia, also known as extrahepatic ductopenia and progressive obliterative cholangiopathy, is a... more...

Related Diseases for Biliary Atresia

Diseases related to Biliary Atresia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 352)
# Related Disease Score Top Affiliating Genes
1 biliary atresia, extrahepatic 35.1 JAG1 GGT1
2 cholangitis 32.1 GPT GGT1 ALB
3 bilirubin metabolic disorder 31.6 GPT GGT1 ALB
4 obstructive jaundice 31.3 HGF GPT GGT1 ALB
5 sclerosing cholangitis 30.9 NR1H4 GGT1 ALB
6 hepatic coma 30.8 GPT ALB
7 liver cirrhosis 30.7 TIMP1 TGFB1 HGF GPT GGT1 ALB
8 acute liver failure 30.6 HGF GPT ALB
9 cholangitis, primary sclerosing 30.5 GPT GGT1 ALB
10 hydronephrosis 30.4 TIMP1 TGFB1 ALB
11 viral hepatitis 30.4 MX1 GPT GGT1 ALB
12 bile duct disease 30.2 SLC10A2 SLC10A1 NR1H4 KRT7 GPT GGT1
13 cholelithiasis 30.1 NR1H4 GPT ALB
14 hepatitis b 30.1 TGFB1 SLC10A1 GPT GGT1 ALB
15 progressive familial intrahepatic cholestasis 30.1 SLC10A2 NR1H4 ATP8B1
16 atp8b1 deficiency 30.0 NR1H4 ATP8B1
17 cholestasis 30.0 SLC10A2 SLC10A1 NR1H4 JAG1 GPT GGT1
18 liver disease 29.9 TGFB1 NR1H4 HGF GPT GGT1 ATP8B1
19 cholangiocarcinoma 29.9 TGFB1 MMP7 KRT7 HGF GGT1
20 cholestasis, progressive familial intrahepatic, 3 29.6 JAG1 ATP8B1
21 hepatocellular carcinoma 28.3 TGFB1 SPP1 KRT7 HGF GGT1 ALB
22 biliary tract disease 28.2 SLC10A2 SLC10A1 NR1H4 KRT7 GGT1 ATP8B1
23 ichthyosis congenita with biliary atresia 12.5
24 biliary atresia with splenic malformation syndrome 12.4
25 syndromic biliary atresia 12.4
26 biliary atresia intrahepatic non syndromic form 12.3
27 biliary atresia intrahepatic syndromic form 12.3
28 biliary atresia and associated disorders 12.3
29 lambert syndrome 11.8
30 hepatoblastoma 11.6
31 heterotaxy 11.6
32 bile acid synthesis defect, congenital, 2 11.3
33 ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis 11.3
34 bile acid synthesis defect, congenital, 1 11.3
35 hyperbiliverdinemia 11.3
36 portal hypertension 10.9
37 varicose veins 10.8
38 bile duct cysts 10.8
39 esophageal varix 10.7
40 ascending cholangitis 10.7
41 neonatal jaundice 10.6
42 situs inversus 10.6
43 hypersplenism 10.6
44 fibrosis of extraocular muscles, congenital, 1 10.5
45 alagille syndrome 1 10.5
46 encephalopathy, progressive, with or without lipodystrophy 10.5
47 splenomegaly 10.5
48 portal vein thrombosis 10.5
49 posttransplant acute limbic encephalitis 10.5
50 kidney hypertrophy 10.5 TGFB1 ALB

Graphical network of the top 20 diseases related to Biliary Atresia:



Diseases related to Biliary Atresia

Symptoms & Phenotypes for Biliary Atresia

UMLS symptoms related to Biliary Atresia:


icterus

GenomeRNAi Phenotypes related to Biliary Atresia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 ALB GGT1 KRT7 MMP7 NR1H4 TGFB1

MGI Mouse Phenotypes related to Biliary Atresia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.17 ATP8B1 GGT1 HGF JAG1 MMP7 NR1H4
2 homeostasis/metabolism MP:0005376 10.15 ALB ATP8B1 GGT1 JAG1 KRT7 MMP7
3 cardiovascular system MP:0005385 10.13 ADD3 HGF JAG1 MMP7 NR1H4 SPP1
4 hematopoietic system MP:0005397 10.1 ADD3 GGT1 HGF JAG1 MMP7 NR1H4
5 digestive/alimentary MP:0005381 10 ALB JAG1 MMP7 NR1H4 SLC10A2 TGFB1
6 mortality/aging MP:0010768 10 ALB ATP8B1 GGT1 HGF JAG1 MMP7
7 liver/biliary system MP:0005370 9.97 ALB ATP8B1 HGF JAG1 NR1H4 SLC10A2
8 neoplasm MP:0002006 9.7 ALB MMP7 NR1H4 SPP1 TGFB1 TIMP1
9 renal/urinary system MP:0005367 9.5 ALB GGT1 JAG1 KRT7 SPP1 TGFB1
10 skeleton MP:0005390 9.23 GGT1 GPT JAG1 NR1H4 SPP1 TGFB1

Drugs & Therapeutics for Biliary Atresia

Drugs for Biliary Atresia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 86)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Meloxicam Approved, Vet_approved Phase 4 71125-38-7 5281106 54677470
2 Anti-Inflammatory Agents Phase 4
3 Analgesics Phase 4
4 Peripheral Nervous System Agents Phase 4
5 Cyclooxygenase Inhibitors Phase 4
6 Analgesics, Non-Narcotic Phase 4
7 Cyclooxygenase 2 Inhibitors Phase 4
8 Anti-Inflammatory Agents, Non-Steroidal Phase 4
9 Antirheumatic Agents Phase 4
10
Pentoxifylline Approved, Investigational Phase 2 6493-05-6 4740
11
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035
12 Antibodies Phase 1, Phase 2
13 Rho(D) Immune Globulin Phase 1, Phase 2
14 Immunoglobulins Phase 1, Phase 2
15 Immunoglobulins, Intravenous Phase 1, Phase 2
16 gamma-Globulins Phase 1, Phase 2
17 Platelet Aggregation Inhibitors Phase 2
18
Bilirubin Phase 2 635-65-4, 69853-43-6 5280352 21252250
19 Pharmaceutical Solutions Phase 2
20 Antioxidants Phase 2
21 Free Radical Scavengers Phase 2
22 Phosphodiesterase Inhibitors Phase 2
23 Protective Agents Phase 2
24 Radiation-Protective Agents Phase 2
25 Vasodilator Agents Phase 2
26 Anti-Infective Agents Phase 2
27 N-monoacetylcystine Phase 2
28 Respiratory System Agents Phase 2
29 Antidotes Phase 2
30 cysteine Phase 2
31 Expectorants Phase 2
32 Antiviral Agents Phase 2
33 Bile Acids and Salts Phase 2
34
Vancomycin Approved Phase 1 1404-90-6 441141 14969
35 Anti-Bacterial Agents Phase 1
36
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
37
Zoledronic Acid Approved 118072-93-8 68740
38
Sevoflurane Approved, Vet_approved 28523-86-6 5206
39
Prednisolone phosphate Approved, Vet_approved 302-25-0
40
Methylprednisolone hemisuccinate Approved 2921-57-5
41
Methylprednisolone Approved, Vet_approved 83-43-2 6741
42
Prednisolone Approved, Vet_approved 50-24-8 5755
43
Magnesium Sulfate Approved, Investigational, Vet_approved 7487-88-9 24083
44
Desflurane Approved 57041-67-5 42113
45
Neomycin Approved, Vet_approved 1404-04-2 8378
46
Protein C Approved
47
Sargramostim Approved, Investigational Early Phase 1 83869-56-1, 123774-72-1
48
Lenograstim Approved, Investigational Early Phase 1 135968-09-1
49
Calcium Approved, Nutraceutical 7440-70-2 271
50
Serine Approved, Nutraceutical 56-45-1 5951

Interventional clinical trials:

(show all 37)
# Name Status NCT ID Phase Drugs
1 Clinical Study About the Role of COX-2 Inhibitor in Liver Cirrhosis With Biliary Atresia Completed NCT02298218 Phase 4 Meloxicam
2 Phase IIIb Study of Corticosteroids as Post-Operative Adjuvant Therapy in Biliary Atresia Unknown status NCT00539565 Phase 3 prednisolone;placebo
3 A Phase 1/2A Trial of Intravenous Immunoglobulin (IVIG) Therapy Following Portoenterostomy in Infants With Biliary Atresia Completed NCT01854827 Phase 1, Phase 2 Intravenous immunoglobulin (IVIG)
4 Outcomes of Autologous Bone Marrow Mononuclear Stem Cell (BMMC) Transplantation for Children Suffering From Liver Cirrhosis Due to Biliary Atresia After Kasai's Operation: An Open Label Uncontrolled Clinical Trial Recruiting NCT03468699 Phase 2
5 A Phase II Trial of Pentoxifylline in Newly-Diagnosed Biliary Atresia Recruiting NCT01774487 Phase 2 Pentoxifylline
6 A Phase 2 Trial of N-Acetylcysteine in Biliary Atresia After Kasai Portoenterostomy Recruiting NCT03499249 Phase 2 N-Acetyl cysteine
7 The Human Gastrointestinal Tract Microbiota in the Setting of Treating Primary Sclerosing Cholangitis and Biliary Atresia With Vancomycin. Completed NCT01322386 Phase 1 Vancomycin
8 The Human Gastrointestinal Tract Microbiota in the Setting of Treating Primary Sclerosing Cholangitis and Biliary Atresia With Vancomycin Recruiting NCT02137668 Phase 1 Oral Vancomycin
9 The Effect of Sevoflurane or Propofol on Brain Injury and Neurocognitive in Pediatric Living Related Liver Transplantation Unknown status NCT03024840 Sevoflurane;Propofol
10 Randomised Control Trial to Investigate the Effectiveness of CoSeal® Surgical Sealant in Reducing Intra-abdominal Adhesions Following the Kasai Hepatoportoenterostomy for Biliary Atresia. Unknown status NCT01745991
11 Clinical and Basic Study for Pediatric Liver Transplantation Unknown status NCT02503384
12 Remote Ischemic Preconditioning Protects Against Hepatic Ischemic and Reperfusion Injury in Pediatric Living Donor Liver Transplantation Unknown status NCT02830841
13 Molecular Genetic Study of Suspected Cases of Osteogenesis Imperfecta Attending Assiut University Children Hospital Unknown status NCT03169192 Zoledronic Acid
14 Comparison the Level of CTGF Protein and Related Cytokine in Pleural Effusion Among Tuberculous Pleurisy and Malignant Pleural Effusion Patients Unknown status NCT00313066
15 Prospective Trial on Survival With Own Liver After Conventional Versus Laparoscopic Kasai for Biliary Atresia Completed NCT01063699
16 the Correlation Between Hepatic Fibrotic Scores and ADC and Other Non-invasive Indicators in Patients With Biliary Atresia Completed NCT02848573
17 Biliary Atresia, Hepatic Buffer Response and Sevoflurane Completed NCT02471209 Sevoflurane
18 Study of Magnesium Sulfate in Children With Reduced Bone Density Secondary to Chronic Cholestatic Liver Disease Completed NCT00007033 magnesium gluconate;magnesium sulfate
19 A Randomized, Double-Blinded, Placebo-Controlled Trial of Corticosteroid Therapy Following Portoenterostomy in Infants With Biliary Atresia Completed NCT00294684 Corticosteroids;Placebo
20 The Comparison of Desflurane and Sevoflurane on Postoperative Recovery and Hepatic Function of Biliary Atresia Patients During Kasai Operation Completed NCT01443572 desflurane anesthetics;sevoflurane anesthetics
21 Use of Probiotics to Prevent Cholangitis in Children With Biliary Atresia Completed NCT00166868 Lactobacillus casei rhamnosus (Lcr35);Neomycin
22 Search for Maternal Microchimerism in Swollen Portal Lymph Nodes of Infants With Biliary Atresia. Completed NCT02292862
23 POLYGEN DEFI-ALPHA : Genetic Polymorphisms Study in Children With Alpha-1 Antitrypsin Deficiency, Included in the DEFI-ALPHA Cohort Completed NCT01862211
24 Development and Validation of a Screening Score for the Biliary Atresia in Infantile Cholestasis: A Prospective Study Recruiting NCT03842150
25 Ultrasound Shear Wave Elastography Evaluation of Suspected and Known Biliary Atresia Recruiting NCT02652533
26 Biliary Atresia Study in Infants and Children (BASIC) Recruiting NCT00345553
27 Effects of Intraoperative Normal Saline vs Lactated Ringer on Outcomes in Pediatric Liver Transplantation: A Double-blind Randomized Trial Recruiting NCT03563378 Lactated Ringer;Normal saline
28 Coordinating Center- Mapping Disease Pathways for Biliary Atresia Recruiting NCT03273049
29 Clinical Follow-up Study on Hepatitis B Virus Infection After Liver Transplantation in Children Recruiting NCT03865966
30 Childhood Liver Disease Research Network (ChiLDReN): A Prospective Database of Infants With Cholestasis Recruiting NCT00061828
31 Longitudinal Study of Mitochondrial Hepatopathies Recruiting NCT01148550
32 Increased Liver Stiffness: A Study of Acoustic Radiation Force Impulse (ARFI) Elastography Recruiting NCT03382119
33 Childhood Liver Disease Research Network (ChiLDReN): FibroScan™ in Pediatric Cholestatic Liver Disease Study Protocol Active, not recruiting NCT02922751
34 Granulocyte-Colony Stimulating Factor Adjunct Therapy for Biliary Atresia Active, not recruiting NCT03395028 Early Phase 1 Granulocyte Colony-Stimulating Factor
35 Dry Blood Spot Screening Test for Neonatal Cholestasis Patients Enrolling by invitation NCT03667534
36 Intestinal Microbiome Composition in Infants With Biliary Atresia Not yet recruiting NCT03890536
37 Dry Blood Spot Screening Test for Biliary Atresia and Other Cholestasis Diseases Not yet recruiting NCT03898765

Search NIH Clinical Center for Biliary Atresia

Cochrane evidence based reviews: biliary atresia

Genetic Tests for Biliary Atresia

Anatomical Context for Biliary Atresia

MalaCards organs/tissues related to Biliary Atresia:

41
Liver, Bone, Testes, T Cells, Heart, Brain, Lymph Node

Publications for Biliary Atresia

Articles related to Biliary Atresia:

(show top 50) (show all 4207)
# Title Authors PMID Year
1
Immunological investigation of the hepatic tissue from infants with biliary atresia. 9 38
19089432 2009
2
Abnormal activation of OPN inflammation pathway in livers of children with biliary atresia and relationship to hepatic fibrosis. 9 38
18704890 2008
3
Evaluation of hepatocyte growth factor in patients with biliary atresia. 9 38
18639691 2008
4
Improvement in accuracy of gamma-glutamyl transferase for differential diagnosis of biliary atresia by correlation with age. 9 38
18773671 2008
5
Adult to adult living-related liver transplant: report on an initial experience in Italy. 9 38
17337259 2007
6
Analysis of connective tissue growth factor promoter polymorphism in Thai children with biliary atresia. 9 38
17375628 2007
7
Association of serum levels of tissue inhibitors of metalloproteinase-1 with clinical outcome in children with biliary atresia. 9 38
17136882 2006
8
Expression of the interferon-induced Mx proteins in biliary atresia. 9 38
16769349 2006
9
Altered hepatobiliary gene expressions in PFIC1: ATP8B1 gene defect is associated with CFTR downregulation. 9 38
16628629 2006
10
Connective tissue growth factor expression is increased in biliary epithelial cells in biliary atresia. 9 38
16291159 2005
11
Kidney volume and plasma hepatocyte growth factor-transforming growth factor beta1 ratio among children with biliary atresia before and after liver transplantation: the reversibility of nephromegaly. 9 38
16253722 2005
12
Developmental expression of canalicular transporter genes in human liver. 9 38
15922475 2005
13
Matrilysin (MMP-7) is a major matrix metalloproteinase upregulated in biliary atresia-associated liver fibrosis. 9 38
15696117 2005
14
Expression of osteopontin correlates with portal biliary proliferation and fibrosis in biliary atresia. 9 38
15845635 2005
15
Connective tissue growth factor and progressive fibrosis in biliary atresia. 9 38
15459777 2005
16
Identification of transforming growth factors actively transcribed during the progress of liver fibrosis in biliary atresia. 9 38
15137003 2004
17
The value of cholinesterase activity after Kasai operation. 9 38
13680289 2003
18
Nephromegaly relates to hepatocyte growth factor dysregulation in biliary atresia. 9 38
12172775 2002
19
Immunosuppressive effect of chenodeoxycholic acid on natural killer cell activity in patients with biliary atresia and hepatitis C virus-related liver cirrhosis. 9 38
12018907 2002
20
Nephromegaly and elevated plasma hepatocyte growth factor-transforming growth factor-beta1 ratio in infants with fulminant hepatitis or biliary atresia. 9 38
11479153 2001
21
Beneficial effect of a traditional herbal medicine (inchin-ko-to) in postoperative biliary atresia patients. 9 38
11527172 2001
22
Cytokine-responsive gene-2/IFN-inducible protein-10 expression in multiple models of liver and bile duct injury suggests a role in tissue regeneration. 9 38
11418676 2001
23
Are stable postoperative biliary atresia patients really stable? 9 38
11315264 2001
24
Expression of collagens type I and IV, osteonectin and transforming growth factor beta-1 (TGFbeta1) in biliary atresia and paucity of intrahepatic bile ducts during infancy. 9 38
10453937 1999
25
Serum IFN-inducible protein-10: a new clinical prognostic predictor of hepatocyte death in biliary atresia. 9 38
10052811 1999
26
Value of gamma-glutamyl transpeptidase for early diagnosis of biliary atresia. 9 38
9884444 1998
27
Establishment of the enzyme-linked immunosorbent assay for connective tissue growth factor (CTGF) and its detection in the sera of biliary atresia. 9 38
9790981 1998
28
Contribution of hepatic parenchymal and nonparenchymal cells to hepatic fibrogenesis in biliary atresia. 9 38
9708812 1998
29
Hepatic growth hormone receptor, insulin-like growth factor I, and insulin-like growth factor-binding protein messenger RNA expression in pediatric liver disease. 9 38
9398004 1997
30
Hepatic basolateral sodium-dependent-bile acid transporter expression in two unusual cases of hypercholanemia and in extrahepatic biliary atresia. 9 38
9141436 1997
31
Nephromegaly and elevated hepatocyte growth factor in children with biliary atresia. 9 38
9016888 1997
32
Assay of gamma-glutamyl transpeptidase activity in amniotic fluid offers a possible prenatal diagnosis of biliary atresia in the rat model. 9 38
9021823 1997
33
Expanding phenotype with severe midline brain anomalies and missense variant supports a causal role for FOXA2 in 20p11.2 deletion syndrome. 38
31294511 2019
34
Has Rotavirus Vaccination Decreased the Prevalence of Biliary Atresia? 38
30222646 2019
35
Neonatal Jaundice. 38
30790186 2019
36
Outcomes of paediatric liver transplant for biliary atresia. 38
31392860 2019
37
A phase 2 trial of N-Acetylcysteine in Biliary atresia after Kasai portoenterostomy. 38
31193715 2019
38
Ultrasound Evaluation of Biliary Atresia Based on Gallbladder Classification: Is 4 Hours of Fasting Necessary? 38
30680769 2019
39
Universal screening of newborns for biliary atresia: Cost-effectiveness of alternative strategies. 38
30871409 2019
40
The "hepatic subcapsular flow sign" in early diagnosis of biliary atresia. 38
31236607 2019
41
Technical Considerations in Liver Transplantation for Biliary Atresia With Situs Inversus. 38
31063622 2019
42
Abundant Expression of Lysyl Oxidase-like 2 Protein in Intrahepatic Bile Ducts of Infants With Biliary Atresia. 38
31436671 2019
43
Polysplenia syndrome with situs ambiguous, common mesentery, and IVC interruption discovered incidentally in an adult. 38
31320964 2019
44
Tubercular hemoptysis in a young liver transplanted patient: Case report. 38
31415374 2019
45
Cystic biliary atresia with paucity of bile ducts and gene mutation in KDM6A: a case report. 38
31414320 2019
46
Diagnostic Yield of an Algorithm for Neonatal and Infantile Cholestasis Integrating Next-Generation Sequencing. 38
31160058 2019
47
Endotipsitis as an indication for pediatric liver transplantation. 38
31002443 2019
48
Hepatic artery reconstruction in living donor liver transplantation: strategy of the extension of graft or recipient artery. 38
30929554 2019
49
Serum Mac-2-binding protein (M2BPGi) as a marker of chronological liver fibrosis in biliary atresia patients with cirrhosis. 38
31392502 2019
50
Health-related quality of life in pre-adolescent liver transplant recipients with biliary atresia: A cross-sectional study. 38
30528863 2019

Variations for Biliary Atresia

Expression for Biliary Atresia

Search GEO for disease gene expression data for Biliary Atresia.

Pathways for Biliary Atresia

GO Terms for Biliary Atresia

Cellular components related to Biliary Atresia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 TIMP1 TGFB1 SPP1 MMP7 JAG1 HGF
2 extracellular exosome GO:0070062 9.76 XPNPEP1 TIMP1 SPP1 MMP7 KRT7 GPT
3 extracellular space GO:0005615 9.56 TIMP1 TGFB1 SPP1 MMP7 HGF GPT
4 platelet alpha granule lumen GO:0031093 8.92 TIMP1 TGFB1 HGF ALB

Biological processes related to Biliary Atresia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Notch signaling pathway GO:0007219 9.61 TGFB1 NR1H4 JAG1
2 response to organic substance GO:0010033 9.54 TIMP1 TGFB1 SPP1
3 response to vitamin D GO:0033280 9.46 TGFB1 SPP1
4 negative regulation of cell-cell adhesion GO:0022408 9.4 TGFB1 JAG1
5 cell activation GO:0001775 9.32 TIMP1 TGFB1
6 bile acid metabolic process GO:0008206 9.26 NR1H4 ATP8B1
7 platelet degranulation GO:0002576 9.26 TIMP1 TGFB1 HGF ALB
8 connective tissue replacement involved in inflammatory response wound healing GO:0002248 9.16 TIMP1 TGFB1
9 bile acid and bile salt transport GO:0015721 8.92 SLC10A2 SLC10A1 NR1H4 ATP8B1

Molecular functions related to Biliary Atresia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.26 TIMP1 TGFB1 JAG1 HGF
2 bile acid:sodium symporter activity GO:0008508 8.62 SLC10A2 SLC10A1

Sources for Biliary Atresia

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