MCID: BLR001
MIFTS: 50

Biliary Atresia

Categories: Gastrointestinal diseases, Liver diseases, Rare diseases

Aliases & Classifications for Biliary Atresia

MalaCards integrated aliases for Biliary Atresia:

Name: Biliary Atresia 12 74 52 36 54 43 15 71
Isolated Atresia of Bile Ducts 52
Non-Syndromic Biliary Atresia 52
Biliary Atresia, Congenital 12
Congenital Biliary Atresia 12
Isolated Biliary Atresia 52
Atresia of Bile Duct 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13608
KEGG 36 H01855
ICD9CM 34 751.61
MeSH 43 D001656
NCIt 49 C34421
SNOMED-CT 67 77480004
ICD10 32 Q44.2
UMLS 71 C0005411

Summaries for Biliary Atresia

KEGG : 36 Biliary atresia (BA) is a congenital, fibro-obliterative obstructive cholangiopathy. It can be a devastating disease in infants invariably leading, if untreated, to cirrhosis, liver failure and death. Patients will be jaundiced and will have pale stools and dark urine. This is due to the inability to excrete conjugated bilirubin into the gastrointestinal tract, which is then excreted into the urine causing its color to darken. The cause of BA is not known with any degree of certainty, though there are a number of hypotheses. One prominent theory regarding the pathogenesis is that bile duct injury is initially caused by a viral infection, and then perpetuated by an autoimmune disorder. Surgical drainage, the only effective intervention, is successful only half of the time. Approximately 80% of patients require one or more liver transplantations with the associated morbidity and mortality issues caused by life-long transplant-related immunosuppression.

MalaCards based summary : Biliary Atresia, also known as isolated atresia of bile ducts, is related to biliary atresia, extrahepatic and bile acid synthesis defect, congenital, 1, and has symptoms including icterus An important gene associated with Biliary Atresia is GGT1 (Gamma-Glutamyltransferase 1), and among its related pathways/superpathways are Immune response IFN alpha/beta signaling pathway and Synthesis of bile acids and bile salts. The drugs Meloxicam and Anti-Inflammatory Agents have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and heart, and related phenotypes are cardiovascular system and growth/size/body region

Disease Ontology : 12 A cholestasis characterized by blockage of the ducts that carry bile from the liver to the gallbladder.

NIH Rare Diseases : 52 The following summary is from Orphanet , a European reference portal for information on rare diseases and orphan drugs. Orpha Number: 30391 Definition Biliary atresia is a rare, progressive obliterative cholangiopathy of the extrahepatic bile ducts, occuring in the embryonic/ perinatal period, leading to severe and persistent jaundice and acholic stool with an unfavorable course in the absence of treatment. Visit the Orphanet disease page for more resources.

Wikipedia : 74 Biliary atresia, also known as extrahepatic ductopenia and progressive obliterative cholangiopathy, is a... more...

Related Diseases for Biliary Atresia

Diseases related to Biliary Atresia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 400)
# Related Disease Score Top Affiliating Genes
1 biliary atresia, extrahepatic 35.1 JAG1 GGT1
2 bile acid synthesis defect, congenital, 1 32.7 GPT GGT1 ALB
3 bile acid synthesis defect, congenital, 2 32.4 SLC10A1 NR1H4 ABCB11
4 portal hypertension 32.0 TGFB1 GPT CCN2 ALB
5 esophageal varix 31.8 GPT GGT1 ALB
6 ascending cholangitis 31.8 GPT ALB
7 obstructive jaundice 31.6 HGF GPT GGT1 ALB
8 cholangitis 31.4 NR1H4 GPT GGT1 ALB ABCB4 ABCB11
9 liver cirrhosis 31.1 TIMP1 TGFB1 HGF GPT GGT1 CCN2
10 parenteral nutrition-associated cholestasis 31.0 GPT GGT1 ABCB4
11 hepatitis a 30.9 GPT GGT1 ALB
12 bile duct disease 30.8 SLC10A2 SLC10A1 NR1H4 MIR142 GPT GGT1
13 acute cholangitis 30.7 GPT GGT1 ALB
14 acute liver failure 30.7 HGF GPT ALB
15 viral hepatitis 30.7 MX1 GPT GGT1 ALB
16 non-alcoholic steatohepatitis 30.6 GPT GGT1
17 hepatic infarction 30.6 GPT ALB
18 bilirubin metabolic disorder 30.5 GPT GGT1 ATP8B1 ALB ABCB4 ABCB11
19 bile duct cysts 30.5 GPT GGT1 CFC1 ATP8B1 ABCB4 ABCB11
20 protein-energy malnutrition 30.5 GPT GGT1 ALB
21 autoimmune hepatitis 30.4 GPT GGT1 ALB
22 sclerosing cholangitis 30.4 NR1H4 GPT GGT1 ALB ABCB4 ABCB11
23 hepatitis b 30.3 TGFB1 SLC10A1 MX1 GPT GGT1 ALB
24 gingival overgrowth 30.3 TIMP1 TGFB1 CCN2
25 kawasaki disease 30.2 TIMP1 GPT ALB
26 diarrhea 30.2 TGFB1 SLC10A2 GPT ALB
27 alagille syndrome 1 30.1 JAG1 CFC1 ATP8B1 ABCB4 ABCB11
28 extrahepatic cholestasis 30.1 SLC10A1 NR1H4 GPT GGT1 ABCB4 ABCB11
29 cholestasis 30.1 SLC10A2 SLC10A1 NR1H4 JAG1 GPT GGT1
30 alcoholic hepatitis 30.1 SPP1 HGF GPT GGT1 ALB
31 hydronephrosis 30.0 TIMP1 TGFB1 ALB
32 chronic kidney disease 29.9 TGFB1 SPP1 HGF CCN2 ALB
33 inherited metabolic disorder 29.9 NR1H4 MIR142 GPT GGT1 ALB
34 cholelithiasis 29.9 NR1H4 GPT GGT1 ALB ABCB4
35 atp8b1 deficiency 29.9 NR1H4 ATP8B1 ABCB11
36 vascular disease 29.9 TIMP1 TGFB1 SPP1 NR1H4 ALB
37 liver disease 29.7 TGFB1 SLC10A1 NR1H4 HGF GPT GGT1
38 primary biliary cirrhosis 29.7 TIMP1 SLC10A1 NR1H4 GPT GGT1 ALB
39 atrial heart septal defect 29.7 JAG1 CFC1 ALB
40 familial intrahepatic cholestasis 29.6 SLC10A2 NR1H4 GGT1 ATP8B1 ABCB4 ABCB11
41 pericholangitis 29.5 SPP1 SLC10A2 SLC10A1 ABCB4 ABCB11
42 progressive familial intrahepatic cholestasis 29.3 SLC10A2 SLC10A1 NR1H4 GGT1 ATP8B1 ABCB4
43 cholestasis, progressive familial intrahepatic, 3 28.7 SLC10A2 SLC10A1 NR1H4 JAG1 ATP8B1 ABCB4
44 biliary tract disease 28.6 SLC10A2 SLC10A1 NR1H4 MIR142 GPT GGT1
45 hepatocellular carcinoma 28.5 TIMP1 TGFB1 SPP1 NR1H4 MMP7 MIR142
46 cholangitis, primary sclerosing 28.4 SLC10A2 SLC10A1 NR1H4 JAG1 GPT GGT1
47 ichthyosis congenita with biliary atresia 12.5
48 biliary atresia with splenic malformation syndrome 12.4
49 syndromic biliary atresia 12.4
50 biliary atresia intrahepatic non syndromic form 12.3

Graphical network of the top 20 diseases related to Biliary Atresia:



Diseases related to Biliary Atresia

Symptoms & Phenotypes for Biliary Atresia

UMLS symptoms related to Biliary Atresia:


icterus

MGI Mouse Phenotypes related to Biliary Atresia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.18 ABCB4 ADD3 ALB CCN2 HGF JAG1
2 growth/size/body region MP:0005378 10.13 ABCB11 ABCB4 ATP8B1 CCN2 GGT1 HGF
3 homeostasis/metabolism MP:0005376 10.07 ABCB11 ABCB4 ALB ATP8B1 CCN2 GGT1
4 digestive/alimentary MP:0005381 9.97 ABCB4 ALB CCN2 JAG1 MMP7 NR1H4
5 liver/biliary system MP:0005370 9.9 ABCB11 ABCB4 ALB ATP8B1 CCN2 HGF
6 neoplasm MP:0002006 9.5 ABCB4 ALB MMP7 NR1H4 SPP1 TGFB1
7 skeleton MP:0005390 9.28 ABCB4 CCN2 GGT1 GPT JAG1 NR1H4

Drugs & Therapeutics for Biliary Atresia

Drugs for Biliary Atresia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 83)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Meloxicam Approved, Vet_approved Phase 4 71125-38-7 5281106 54677470
2 Anti-Inflammatory Agents Phase 4
3 Analgesics Phase 4
4 Anti-Inflammatory Agents, Non-Steroidal Phase 4
5 Analgesics, Non-Narcotic Phase 4
6 Cyclooxygenase Inhibitors Phase 4
7 Cyclooxygenase 2 Inhibitors Phase 4
8 Antirheumatic Agents Phase 4
9
Pentoxifylline Approved, Investigational Phase 2 6493-05-6 4740
10
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035
11
Cysteine Approved, Nutraceutical Phase 2 52-90-4 5862
12 Vasodilator Agents Phase 2
13 Phosphodiesterase Inhibitors Phase 2
14 Radiation-Protective Agents Phase 2
15 Rho(D) Immune Globulin Phase 1, Phase 2
16 Immunoglobulins Phase 1, Phase 2
17 Immunoglobulins, Intravenous Phase 1, Phase 2
18 Antibodies Phase 1, Phase 2
19 gamma-Globulins Phase 1, Phase 2
20
Bilirubin Phase 2 635-65-4, 69853-43-6 5280352 21252250
21 Free Radical Scavengers Phase 2
22 Antioxidants Phase 2
23 Pharmaceutical Solutions Phase 2
24 Protective Agents Phase 2
25 Anti-Infective Agents Phase 2
26 Respiratory System Agents Phase 2
27 N-monoacetylcystine Phase 2
28 Antiviral Agents Phase 2
29 Bile Acids and Salts Phase 2
30 Antidotes Phase 2
31 Expectorants Phase 2
32
Vancomycin Approved Phase 1 1404-90-6 441141 14969
33 Anti-Bacterial Agents Phase 1
34
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
35
Zoledronic Acid Approved 118072-93-8 68740
36
Sevoflurane Approved, Vet_approved 28523-86-6 5206
37
Methylprednisolone hemisuccinate Approved 2921-57-5
38
Prednisolone Approved, Vet_approved 50-24-8 5755
39
Methylprednisolone Approved, Vet_approved 83-43-2 6741
40
Prednisolone phosphate Approved, Vet_approved 302-25-0
41 Prednisolone acetate Approved, Vet_approved 52-21-1
42
Magnesium Sulfate Approved, Investigational, Vet_approved 7487-88-9 24083
43
Desflurane Approved 57041-67-5 42113
44
Neomycin Approved, Vet_approved 1404-04-2 8378
45
Protein C Approved
46
Sargramostim Approved, Investigational Early Phase 1 123774-72-1, 83869-56-1
47
Lenograstim Approved, Investigational Early Phase 1 135968-09-1
48
Calcium Approved, Nutraceutical 7440-70-2 271
49
Prednisolone hemisuccinate Experimental 2920-86-7
50 Hypnotics and Sedatives

Interventional clinical trials:

(show all 38)
# Name Status NCT ID Phase Drugs
1 Clinical Study About the Role of COX-2 Inhibitor in Liver Cirrhosis With Biliary Atresia Completed NCT02298218 Phase 4 Meloxicam
2 Phase IIIb Study of Corticosteroids as Post-Operative Adjuvant Therapy in Biliary Atresia Unknown status NCT00539565 Phase 3 prednisolone;placebo
3 A Phase II Trial of Pentoxifylline in Newly-Diagnosed Biliary Atresia Unknown status NCT01774487 Phase 2 Pentoxifylline
4 A Phase 1/2A Trial of Intravenous Immunoglobulin (IVIG) Therapy Following Portoenterostomy in Infants With Biliary Atresia Completed NCT01854827 Phase 1, Phase 2 Intravenous immunoglobulin (IVIG)
5 Outcomes of Autologous Bone Marrow Mononuclear Stem Cell (BMMC) Transplantation for Children Suffering From Liver Cirrhosis Due to Biliary Atresia After Kasai's Operation: An Open Label Uncontrolled Clinical Trial Recruiting NCT03468699 Phase 2
6 A Phase 2 Trial of N-Acetylcysteine in Biliary Atresia After Kasai Portoenterostomy Recruiting NCT03499249 Phase 2 N-Acetyl cysteine
7 The Human Gastrointestinal Tract Microbiota in the Setting of Treating Primary Sclerosing Cholangitis and Biliary Atresia With Vancomycin. Completed NCT01322386 Phase 1 Vancomycin
8 The Human Gastrointestinal Tract Microbiota in the Setting of Treating Primary Sclerosing Cholangitis and Biliary Atresia With Vancomycin Recruiting NCT02137668 Phase 1 Oral Vancomycin
9 The Effect of Sevoflurane or Propofol on Brain Injury and Neurocognitive in Pediatric Living Related Liver Transplantation Unknown status NCT03024840 Sevoflurane;Propofol
10 Impaired T-Lymphocyte Proliferative Function in Biliary Atresia Children With Prolonged Jaundice Unknown status NCT00155194
11 Randomised Control Trial to Investigate the Effectiveness of CoSeal® Surgical Sealant in Reducing Intra-abdominal Adhesions Following the Kasai Hepatoportoenterostomy for Biliary Atresia. Unknown status NCT01745991
12 Clinical and Basic Study for Pediatric Liver Transplantation Unknown status NCT02503384
13 Remote Ischemic Preconditioning Protects Against Hepatic Ischemic and Reperfusion Injury in Pediatric Living Donor Liver Transplantation Unknown status NCT02830841
14 Molecular Genetic Study of Suspected Cases of Osteogenesis Imperfecta Attending Assiut University Children Hospital Unknown status NCT03169192 Zoledronic Acid
15 Comparison the Level of CTGF Protein and Related Cytokine in Pleural Effusion Among Tuberculous Pleurisy and Malignant Pleural Effusion Patients Unknown status NCT00313066
16 Prospective Trial on Survival With Own Liver After Conventional Versus Laparoscopic Kasai for Biliary Atresia Completed NCT01063699
17 the Correlation Between Hepatic Fibrotic Scores and ADC and Other Non-invasive Indicators in Patients With Biliary Atresia Completed NCT02848573
18 Biliary Atresia, Hepatic Buffer Response and Sevoflurane Completed NCT02471209 Sevoflurane
19 Study of Magnesium Sulfate in Children With Reduced Bone Density Secondary to Chronic Cholestatic Liver Disease Completed NCT00007033 magnesium gluconate;magnesium sulfate
20 Ultrasound Shear Wave Elastography Evaluation of Suspected and Known Biliary Atresia Completed NCT02652533
21 A Randomized, Double-Blinded, Placebo-Controlled Trial of Corticosteroid Therapy Following Portoenterostomy in Infants With Biliary Atresia Completed NCT00294684 Corticosteroids;Placebo
22 The Comparison of Desflurane and Sevoflurane on Postoperative Recovery and Hepatic Function of Biliary Atresia Patients During Kasai Operation Completed NCT01443572 desflurane anesthetics;sevoflurane anesthetics
23 Use of Probiotics to Prevent Cholangitis in Children With Biliary Atresia Completed NCT00166868 Lactobacillus casei rhamnosus (Lcr35);Neomycin
24 Search for Maternal Microchimerism in Swollen Portal Lymph Nodes of Infants With Biliary Atresia. Completed NCT02292862
25 POLYGEN DEFI-ALPHA : Genetic Polymorphisms Study in Children With Alpha-1 Antitrypsin Deficiency, Included in the DEFI-ALPHA Cohort Completed NCT01862211
26 Development and Validation of a Screening Score for the Biliary Atresia in Infantile Cholestasis: A Prospective Study Recruiting NCT03842150
27 Biliary Atresia Study in Infants and Children (BASIC) Recruiting NCT00345553
28 Effects of Intraoperative Normal Saline vs Lactated Ringer on Outcomes in Pediatric Liver Transplantation: A Double-blind Randomized Trial Recruiting NCT03563378 Lactated Ringer;Normal saline
29 Coordinating Center- Mapping Disease Pathways for Biliary Atresia Recruiting NCT03273049
30 Childhood Liver Disease Research Network (ChiLDReN): A Prospective Database of Infants With Cholestasis Recruiting NCT00061828
31 Clinical Follow-up Study on Hepatitis B Virus Infection After Liver Transplantation in Children Recruiting NCT03865966
32 Longitudinal Study of Mitochondrial Hepatopathies Recruiting NCT01148550
33 Increased Liver Stiffness: A Study of Acoustic Radiation Force Impulse (ARFI) Elastography Recruiting NCT03382119
34 Childhood Liver Disease Research Network (ChiLDReN): FibroScan™ in Pediatric Cholestatic Liver Disease Study Protocol Active, not recruiting NCT02922751
35 Granulocyte-Colony Stimulating Factor Adjunct Therapy for Biliary Atresia Active, not recruiting NCT03395028 Early Phase 1 Granulocyte Colony-Stimulating Factor
36 Dry Blood Spot Screening Test for Neonatal Cholestasis Patients Enrolling by invitation NCT03667534
37 Intestinal Microbiome Composition in Infants With Biliary Atresia Not yet recruiting NCT03890536
38 Dry Blood Spot Screening Test for Biliary Atresia and Other Cholestasis Diseases Not yet recruiting NCT03898765

Search NIH Clinical Center for Biliary Atresia

Cochrane evidence based reviews: biliary atresia

Genetic Tests for Biliary Atresia

Anatomical Context for Biliary Atresia

MalaCards organs/tissues related to Biliary Atresia:

40
Liver, Bone, Heart, Testes, Kidney, T Cells, Lymph Node

Publications for Biliary Atresia

Articles related to Biliary Atresia:

(show top 50) (show all 4287)
# Title Authors PMID Year
1
Immunological investigation of the hepatic tissue from infants with biliary atresia. 54 61
19089432 2009
2
Abnormal activation of OPN inflammation pathway in livers of children with biliary atresia and relationship to hepatic fibrosis. 54 61
18704890 2008
3
Evaluation of hepatocyte growth factor in patients with biliary atresia. 54 61
18639691 2008
4
Improvement in accuracy of gamma-glutamyl transferase for differential diagnosis of biliary atresia by correlation with age. 54 61
18773671 2008
5
Adult to adult living-related liver transplant: report on an initial experience in Italy. 54 61
17337259 2007
6
Analysis of connective tissue growth factor promoter polymorphism in Thai children with biliary atresia. 54 61
17375628 2007
7
Association of serum levels of tissue inhibitors of metalloproteinase-1 with clinical outcome in children with biliary atresia. 54 61
17136882 2006
8
Expression of the interferon-induced Mx proteins in biliary atresia. 54 61
16769349 2006
9
Altered hepatobiliary gene expressions in PFIC1: ATP8B1 gene defect is associated with CFTR downregulation. 54 61
16628629 2006
10
Connective tissue growth factor expression is increased in biliary epithelial cells in biliary atresia. 54 61
16291159 2005
11
Kidney volume and plasma hepatocyte growth factor-transforming growth factor beta1 ratio among children with biliary atresia before and after liver transplantation: the reversibility of nephromegaly. 54 61
16253722 2005
12
Developmental expression of canalicular transporter genes in human liver. 54 61
15922475 2005
13
Matrilysin (MMP-7) is a major matrix metalloproteinase upregulated in biliary atresia-associated liver fibrosis. 54 61
15696117 2005
14
Expression of osteopontin correlates with portal biliary proliferation and fibrosis in biliary atresia. 54 61
15845635 2005
15
Connective tissue growth factor and progressive fibrosis in biliary atresia. 54 61
15459777 2005
16
Identification of transforming growth factors actively transcribed during the progress of liver fibrosis in biliary atresia. 54 61
15137003 2004
17
The value of cholinesterase activity after Kasai operation. 54 61
13680289 2003
18
Nephromegaly relates to hepatocyte growth factor dysregulation in biliary atresia. 54 61
12172775 2002
19
Immunosuppressive effect of chenodeoxycholic acid on natural killer cell activity in patients with biliary atresia and hepatitis C virus-related liver cirrhosis. 54 61
12018907 2002
20
Nephromegaly and elevated plasma hepatocyte growth factor-transforming growth factor-beta1 ratio in infants with fulminant hepatitis or biliary atresia. 54 61
11479153 2001
21
Beneficial effect of a traditional herbal medicine (inchin-ko-to) in postoperative biliary atresia patients. 54 61
11527172 2001
22
Cytokine-responsive gene-2/IFN-inducible protein-10 expression in multiple models of liver and bile duct injury suggests a role in tissue regeneration. 54 61
11418676 2001
23
Are stable postoperative biliary atresia patients really stable? 54 61
11315264 2001
24
Expression of collagens type I and IV, osteonectin and transforming growth factor beta-1 (TGFbeta1) in biliary atresia and paucity of intrahepatic bile ducts during infancy. 54 61
10453937 1999
25
Serum IFN-inducible protein-10: a new clinical prognostic predictor of hepatocyte death in biliary atresia. 54 61
10052811 1999
26
Value of gamma-glutamyl transpeptidase for early diagnosis of biliary atresia. 54 61
9884444 1998
27
Establishment of the enzyme-linked immunosorbent assay for connective tissue growth factor (CTGF) and its detection in the sera of biliary atresia. 54 61
9790981 1998
28
Contribution of hepatic parenchymal and nonparenchymal cells to hepatic fibrogenesis in biliary atresia. 54 61
9708812 1998
29
Hepatic growth hormone receptor, insulin-like growth factor I, and insulin-like growth factor-binding protein messenger RNA expression in pediatric liver disease. 54 61
9398004 1997
30
Hepatic basolateral sodium-dependent-bile acid transporter expression in two unusual cases of hypercholanemia and in extrahepatic biliary atresia. 54 61
9141436 1997
31
Nephromegaly and elevated hepatocyte growth factor in children with biliary atresia. 54 61
9016888 1997
32
Assay of gamma-glutamyl transpeptidase activity in amniotic fluid offers a possible prenatal diagnosis of biliary atresia in the rat model. 54 61
9021823 1997
33
Society of pediatric liver transplantation: Current registry status 2011-2018. 61
31680409 2020
34
Biliary Atresia: Biliary-Enteric Drainage or Primary Liver Transplant? 61
31517392 2020
35
Gut microbial profile in biliary atresia: a case-control study. 61
31271681 2020
36
The Epidemiology and Etiology of Cholangitis After Kasai Portoenterostomy in Patients With Biliary Atresia. 61
31978011 2020
37
TGF-β Signaling Plays a Pivotal Role During Developmental Biliary Atresia in Sea Lamprey (Petromyzon marinus). 61
32025607 2020
38
Ultrasound, shear-wave elastography, and magnetic resonance imaging in native liver survivor patients with biliary atresia after Kasai portoenterostomy: correlation with medical outcome after treatment. 61
32008344 2020
39
Severity of Ascites Is Associated with Increased Mortality in Patients with Cirrhosis Secondary to Biliary Atresia. 61
31907773 2020
40
Blood stream infections in children in the first year after liver transplantation at wits Donald Gordon Medical Centre, South Africa. 61
31985168 2020
41
Clinical study of argatroban for preventing vascular thrombosis in the early period after pediatric living-related donor liver transplantation. 61
31944491 2020
42
Neurodevelopmental Outcomes in Preschool and School Aged Children With Biliary Atresia and Their Native Liver. 61
31503218 2020
43
Comparison of 2 Diagnostic Criteria for Hepatopulmonary Syndrome- High Prevalence in Biliary Atresia: Comparison of the available Diagnostic Criteria for Hepatopulmonary Syndrome in Children with Liver Diseases. 61
31939865 2020
44
Improved Outcomes for Liver Transplantation in Patients with Biliary Atresia Since Pediatric End-Stage Liver Disease Implementation: Analysis of the Society of Pediatric Liver Transplantation Registry. 61
32005543 2020
45
A novel timesaving and semiquantitative method for radionuclide hepatobiliary scintigraphy for suspected biliary atresia. 61
32005064 2020
46
Gallbladder wall abnormality in biliary atresia of mouse Sox17+/- neonates and human infants. 61
31996362 2020
47
A Novel CFC1 Mutation in a Family With Heterotaxy and Biliary Atresia Splenic Malformation Syndromes. 61
31633655 2020
48
Regulation of bile acid metabolism in biliary atresia: Reduction of FGF19 by Kasai portoenterostomy and possible relation to early outcome. 61
31976601 2020
49
The Outcomes of Portal Vein Reconstruction With Vein Graft Interposition in Pediatric Liver Transplantation for Small Children With Biliary Atresia. 61
31205260 2020
50
Quantitative Liver Fibrosis Using Collagen Hybridizing Peptide to Predict Native Liver Survival in Biliary Atresia: A Pilot Study. 61
31568155 2020

Variations for Biliary Atresia

Expression for Biliary Atresia

Search GEO for disease gene expression data for Biliary Atresia.

Pathways for Biliary Atresia

GO Terms for Biliary Atresia

Cellular components related to Biliary Atresia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.91 TIMP1 TGFB1 SPP1 MMP7 JAG1 HGF
2 extracellular space GO:0005615 9.65 TIMP1 TGFB1 SPP1 MMP7 MIR142 HGF
3 extracellular matrix GO:0031012 9.62 TIMP1 TGFB1 MMP7 CCN2
4 intercellular canaliculus GO:0046581 9.16 ABCB4 ABCB11
5 platelet alpha granule lumen GO:0031093 8.92 TIMP1 TGFB1 HGF ALB

Biological processes related to Biliary Atresia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to estradiol GO:0032355 9.65 TGFB1 GGT1 CCN2
2 aging GO:0007568 9.62 TIMP1 TGFB1 MMP7 CCN2
3 response to organic substance GO:0010033 9.61 TIMP1 TGFB1 SPP1
4 negative regulation of cell-cell adhesion GO:0022408 9.46 TGFB1 JAG1
5 bile acid metabolic process GO:0008206 9.4 NR1H4 ATP8B1
6 cell activation GO:0001775 9.37 TIMP1 TGFB1
7 connective tissue development GO:0061448 9.26 TGFB1 CCN2
8 platelet degranulation GO:0002576 9.26 TIMP1 TGFB1 HGF ALB
9 connective tissue replacement involved in inflammatory response wound healing GO:0002248 9.16 TIMP1 TGFB1
10 bile acid and bile salt transport GO:0015721 9.02 SLC10A2 SLC10A1 NR1H4 ATP8B1 ABCB11

Molecular functions related to Biliary Atresia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.02 TIMP1 TGFB1 JAG1 HGF CCN2
2 bile acid:sodium symporter activity GO:0008508 8.96 SLC10A2 SLC10A1

Sources for Biliary Atresia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
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43 MeSH
44 MESH via Orphanet
45 MGI
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56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
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70 Tocris
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72 UMLS via Orphanet
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