Biliary Cirrhosis, Primary, 2 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Biliary Cirrhosis, Primary, 2

MalaCards integrated aliases for Biliary Cirrhosis, Primary, 2:

Name: Biliary Cirrhosis, Primary, 2 ⁵⁸ ¹³ ⁷⁴

Pbc2 ⁵⁸

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases Endocrine diseases Liver diseases

See all MalaCards categories (disease lists)

External Ids:

OMIM ⁵⁸ 613007

MedGen ⁴³ C2751696

UMLS ⁷⁴ C2751696

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Summaries for Biliary Cirrhosis, Primary, 2

OMIM : ⁵⁸ Primary biliary cirrhosis (PBC) is a chronic, progressive cholestatic liver disease that usually affects middle-aged women and eventually leads to liver failure (summary by Kaplan, 1996). For a discussion of genetic heterogeneity of primary biliary cirrhosis (PBC), see PBC1 (109720). (613007)

MalaCards based summary : Biliary Cirrhosis, Primary, 2, also known as pbc2, is related to primary biliary cirrhosis and biliary cirrhosis, primary, 1. An important gene associated with Biliary Cirrhosis, Primary, 2 is PBC2 (Biliary Cirrhosis, Primary, 2). The drugs Atorvastatin and Hydroxymethylglutaryl-CoA Reductase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include liver.

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Related Diseases for Biliary Cirrhosis, Primary, 2

Diseases in the Primary Biliary Cirrhosis family:

Biliary Cirrhosis, Primary, 1	Biliary Cirrhosis, Primary, 2
Biliary Cirrhosis, Primary, 3	Biliary Cirrhosis, Primary, 4
Biliary Cirrhosis, Primary, 5

Diseases related to Biliary Cirrhosis, Primary, 2 via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score
1	primary biliary cirrhosis	11.5
2	biliary cirrhosis, primary, 1	10.1
3	primary biliary cholangitis	10.1

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Symptoms & Phenotypes for Biliary Cirrhosis, Primary, 2

Clinical features from OMIM:

613007

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Drugs & Therapeutics for Biliary Cirrhosis, Primary, 2

Drugs for Biliary Cirrhosis, Primary, 2 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Atorvastatin

Approved

Phase 3

134523-00-5

60823

Synonyms:

(3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid

(3R,5R)-7-[3-(anilinocarbonyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid

(betaR,deltaR)-2-(p-Fluorophenyl)-beta,delta-dihydroxy-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrole-1-heptanoic acid

(R-(R*,r*))-2-(4-fluorophenyl)-b,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-1H-pyrrole-1-heptanoate

(R-(R*,r*))-2-(4-fluorophenyl)-b,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-1H-pyrrole-1-heptanoic acid

(R-(R*,r*))-2-(4-fluorophenyl)-b,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-1H-pyrrole-1-heptanoate

(R-(R*,r*))-2-(4-fluorophenyl)-b,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-1H-pyrrole-1-heptanoic acid

(R-(R*,r*))-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-1H-pyrrole-1-heptanoate

(R-(R*,r*))-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-1H-pyrrole-1-heptanoic acid

(R-(R*,R*))-2-(4-Fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-1H-pyrrole-1-heptanoic acid

(R-(R*,r*))-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-1H-pyrrole-1-heptanoate

(R-(R*,r*))-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-1H-pyrrole-1-heptanoic acid

134523-00-5

134523-03-8

7-[2-(4-FLUORO-PHENYL)-5-ISOPROPYL-3-PHENYL-4-PHENYLCARBAMOYL-PYRROL-1-YL]- 3,5-DIHYDROXY-HEPTANOIC ACID

7-[2-(4-fluoro-PHENYL)-5-isopropyl-3-phenyl-4-phenylcarbamoyl-pyrrol-1-yl]-3,5-dihydroxy-heptanoate

7-[2-(4-fluoro-PHENYL)-5-isopropyl-3-phenyl-4-phenylcarbamoyl-pyrrol-1-yl]-3,5-dihydroxy-heptanoIC ACID

AC-15611

AC1L1TZT

AC1Q1OZQ

AKOS000281127

Anhydrous, atorvastatin calcium

Atogal

Atorlip

Atorpic

atorvastatin

Atorvastatin

Atorvastatin (INN)

Atorvastatin [INN:BAN]

Atorvastatin acid

Atorvastatin calcium

Atorvastatin calcium anhydrous

Atorvastatin calcium hydrate

Atorvastatin calcium trihydrate

Atorvastatin, calcium salt

atorvastatina

Atorvastatina

atorvastatine

Atorvastatine

atorvastatinium

atorvastatinum

Atorvastatinum

atrovastin

BIDD:GT0336

C06834

C33H35FN2O5

Calcium anhydrous, atorvastatin

Calcium hydrate, atorvastatin

Calcium salt atorvastatin

Calcium trihydrate, atorvastatin

Calcium, atorvastatin

Cardyl

CCRIS 7159

CHEBI:39548

CHEMBL1487

CI 981

CID60823

D07474

DB01076

Faboxim

Hipolixan

HSDB 7039

Hydrate, atorvastatin calcium

Lipitor

Lipitor (TN)

Lipitor(TM)

Lipotropic

Lipovastatinklonal

Liprimar

Liptonorm

Lowden

LS-136975

MolPort-000-883-773

NCGC00159458-02

nchembio.301-comp8

Normalip

Sincol

Sortis

Sortis (TN)

Sotis

Torvacard

Torvast

Totalip

Tozalip

Trihydrate, atorvastatin calcium

Tulip

UNII-A0JWA85V8F

Vastina

Xanator

Xarator

Xavator

Zurinel

2

Hydroxymethylglutaryl-CoA Reductase Inhibitors

Phase 3

3

Hypolipidemic Agents

Phase 3

4

Anticholesteremic Agents

Phase 3

5

Lipid Regulating Agents

Phase 3

6

Antimetabolites

Phase 3

7

Ursodeoxycholic acid

Approved, Investigational

128-13-2

31401

Synonyms:

(3a,5b,7b)-3,7-Dihydroxycholan-24-Oate

(3a,5b,7b)-3,7-Dihydroxy-cholan-24-Oate

(3a,5b,7b)-3,7-Dihydroxycholan-24-Oic acid

(3a,5b,7b)-3,7-Dihydroxy-cholan-24-Oic acid

(3alpha,5beta,7beta)-3,7-Dihydroxycholan-24-Oate

(3alpha,5beta,7beta)-3,7-dihydroxycholan-24-oic acid

(3alpha,5beta,7beta)-3,7-Dihydroxycholan-24-Oic acid

(3alpha,5beta,7beta,8xi)-3,7-dihydroxycholan-24-oic acid

(3α,5β,7β)-3,7-dihydroxycholan-24-Oate

(3α,5β,7β)-3,7-dihydroxycholan-24-oic acid

(3α,5β,7β)-3,7-dihydroxycholan-24-Oic acid

(4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid

128-13-2

17-beta-(1-Methyl-3-carboxypropyl)etiocholane-3-alpha,7-beta-diol

3 alpha,7 beta Dihydroxy 5 beta cholan 24 Oic acid

3 alpha,7 beta-Dihydroxy-5 beta-cholan-24-oic Acid

3 alpha,7 beta-Dihydroxy-5 beta-cholan-24-Oic acid

3,7-Dihydroxycholan-24-oic acid

3,7-Dihydroxycholan-24-Oic acid

3a,7b-Dihydroxy-5b-cholan-24-Oate

3a,7b-Dihydroxy-5b-cholan-24-Oic acid

3alpha,7beta-Dihydroxy-5beta-cholan-24-Oate

3alpha,7beta-Dihydroxy-5beta-cholan-24-oic acid

3alpha,7beta-Dihydroxy-5beta-cholan-24-Oic acid

3alpha,7beta-Dihydroxy-5beta-cholanic acid

3-alpha,7-beta-Dihydroxy-5-beta-cholanoic acid

3-alpha,7-beta-Dihydroxycholanic acid

3-alpha,7-beta-Dioxycholanic acid

3α,7β-dihydroxy-5β-cholan-24-Oate

3α,7β-dihydroxy-5β-cholan-24-Oic acid

4-10-00-01604 (Beilstein Handbook Reference)

50809-41-1

5beta-Cholan-24-oic acid-3alpha,7beta-diol

5beta-Cholanic Acid-3alpha,7beta-diol

7beta-Hydroxylithocholic acid

7-beta-Hydroxylithocholic acid

80225-86-1

AB00513977

AC-18919

AC1L1LJH

AC-2081

Acid, deoxyursocholic

Acid, ursacholic

Acid, ursodeoxycholic

Acide ursodesoxycholique

Acide ursodesoxycholique [INN-French]

Acido ursodeossicolico

Acido ursodeossicolico [Italian]

Acido ursodeoxicolico

Acido ursodeoxicolico [INN-Spanish]

Acidum ursodeoxycholicum

Acidum ursodeoxycholicum [INN-Latin]

Actigall

Actigall (TN)

Antigall

Antigen brand OF ursodeoxycholic acid

Arsacol

Aventis brand OF ursodeoxycholic acid

Axcan brand OF ursodeoxycholic acid

BB_NC-2372

BPBio1_001052

BRN 3219888

BSPBio_000956

C07880

C24H40O4

CCRIS 5502

CHEBI:9907

CHEMBL1551

CHEMBL73390

chenodeoxycholic acid

Cholan-24-oic acid, 3,7-dihydroxy-, (3-alpha,5-beta,7-beta)- (9CI)

Cholit-ursan

Cholofalk

CID11516715

CID31401

CP Brand OF ursodeoxycholic acid

CPD000058403

CPD-10534

D00734

DB01586

Delursan

Deoxyursocholic acid

Deoxyursocholic Acid

Destolit

Deursil

Dom-ursodiol c

EINECS 204-879-3

Estedi brand OF ursodeoxycholic acid

Falk brand OF ursodeoxycholic acid

Farmasa brand OF ursodeoxycholic acid

Galen brand OF ursodeoxycholic acid

Heumann brand OF ursodeoxycholic acid

HMS1570P18

ISO-URSODEOXYCHOLIC ACID

IU5

Litursol

LMST04010033

LS-53033

Lyeton

MLS000028461

MLS001066373

MolPort-001-794-630

MolPort-005-932-884

NCGC00179363-01

NCI60_028904

Niddapharm brand OF ursodeoxycholic acid

Norgine brand OF ursodeoxycholic acid

NSC 657950

NSC 683769

Orphan brand OF ursodeoxycholic acid

Peptarom

PHL-ursodiol c

PMS-ursodiol c

Prestwick0_000958

Prestwick1_000958

Prestwick2_000958

Prestwick3_000958

Provalis brand OF ursodeoxycholic acid

S1643_Selleck

SAM002264653

Sanofi synthelabo brand OF ursodeoxycholic acid

SMP2_000012

SMR000058403

Sodium ursodeoxycholate

Sodium Ursodeoxycholate

Solutrat

SPBio_003105

tramedico Brand OF ursodeoxycholic acid

U0030

U5127_SIGMA

U-9000

UDCA

UDCS

UNII-724L30Y2QR

Urdox

Urosdesoxycholate

Urosdesoxycholic acid

Urosiol

Ursacholic acid

Ursacholic Acid

Ursacol

Urso

UrSO

Urso (TN)

Urso 250

Urso DS

Urso Forte

urso Heumann

Ursobilane

Ursobilin

Ursochol

Ursodamor

Ursodeoxy cholic acid

ursodeoxycholate

Ursodeoxycholate

Ursodeoxycholate, sodium

Ursodeoxycholic acid

URSODEOXYCHOLIC ACID

Ursodeoxycholic acid (JP15/INN)

Ursodeoxycholic acid, UDCA, Ursosan, Ursofalk, Urso Forte, Udiliv, Ursodiol

Ursodeoxycholicacid

Ursodesoxycholic acid

Ursodexycholate

Ursodexycholic acid

Ursodexycholic Acid

ursodiol

Ursodiol

Ursodiol (USP)

Ursodiol [USAN]

Ursofalk

Ursogal

Ursolite

Ursolvan

Ursosan

Vita brand OF ursodeoxycholic acid

Zambon brand OF ursodeoxycholic acid

8

Antibodies

9

Immunologic Factors

10

Gastrointestinal Agents

11

Immunoglobulins, Intravenous

12

gamma-Globulins

13

Rho(D) Immune Globulin

14

Cholagogues and Choleretics

15

Immunoglobulins

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Safety and Efficacy of Long-Term Treatment With Atorvastatin in Patients With Primary Biliary Cirrhosis	Completed	NCT00844402	Phase 3	Atorvastatin
2	The Comparison About the Response of Ursodeoxycholic Acid in Primary Biliary Cholangitis Only and Primary Biliary Cholangitis With High Immune Globulin G or Aminotransferase at West China Hospital	Completed	NCT03322943

Search NIH Clinical Center for Biliary Cirrhosis, Primary, 2

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Genetic Tests for Biliary Cirrhosis, Primary, 2

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Anatomical Context for Biliary Cirrhosis, Primary, 2

MalaCards organs/tissues related to Biliary Cirrhosis, Primary, 2:

⁴²

Liver

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Publications for Biliary Cirrhosis, Primary, 2

Articles related to Biliary Cirrhosis, Primary, 2:

#	Title	Authors	Year
1	Updating prognosis in primary biliary cirrhosis using a time-dependent Cox regression model. PBC1 and PBC2 trial groups. ( 8253362 )	Christensen E...Williams R	1993
2	Evidence that rabbit cytochrome P-450 K is encoded by the plasmid pP-450 PBc2. ( 3801023 )	Finlayson MJ...Johnson EF	1986

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Genes for Biliary Cirrhosis, Primary, 2

Genes related to Biliary Cirrhosis, Primary, 2 (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	PBC2	Biliary Cirrhosis, Primary, 2	Genetic Locus	58.7	Susceptibility factor ⁵⁸ GeneCards inferred via : Gene name (show sections)

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Variations for Biliary Cirrhosis, Primary, 2

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Expression for Biliary Cirrhosis, Primary, 2

Search GEO for disease gene expression data for Biliary Cirrhosis, Primary, 2.

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Pathways for Biliary Cirrhosis, Primary, 2

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GO Terms for Biliary Cirrhosis, Primary, 2

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Sources for Biliary Cirrhosis, Primary, 2

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia

Biliary Cirrhosis, Primary, 2 (PBC2)

Aliases & Classifications for Biliary Cirrhosis, Primary, 2

MalaCards integrated aliases for Biliary Cirrhosis, Primary, 2:

Classifications:

External Ids:

Summaries for Biliary Cirrhosis, Primary, 2

Related Diseases for Biliary Cirrhosis, Primary, 2

Diseases in the Primary Biliary Cirrhosis family:

Diseases related to Biliary Cirrhosis, Primary, 2 via text searches within MalaCards or GeneCards Suite gene sharing:

Symptoms & Phenotypes for Biliary Cirrhosis, Primary, 2

Clinical features from OMIM:

Drugs & Therapeutics for Biliary Cirrhosis, Primary, 2

Drugs for Biliary Cirrhosis, Primary, 2 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Genetic Tests for Biliary Cirrhosis, Primary, 2

Anatomical Context for Biliary Cirrhosis, Primary, 2

MalaCards organs/tissues related to Biliary Cirrhosis, Primary, 2:

Publications for Biliary Cirrhosis, Primary, 2

Articles related to Biliary Cirrhosis, Primary, 2:

Genes for Biliary Cirrhosis, Primary, 2

Genes related to Biliary Cirrhosis, Primary, 2 (1 elite genes):

Variations for Biliary Cirrhosis, Primary, 2

Expression for Biliary Cirrhosis, Primary, 2

Pathways for Biliary Cirrhosis, Primary, 2

GO Terms for Biliary Cirrhosis, Primary, 2

Sources for Biliary Cirrhosis, Primary, 2