PBC2
MCID: BLR016
MIFTS: 17

Biliary Cirrhosis, Primary, 2 (PBC2)

Categories: Endocrine diseases, Gastrointestinal diseases, Immune diseases, Liver diseases

Aliases & Classifications for Biliary Cirrhosis, Primary, 2

MalaCards integrated aliases for Biliary Cirrhosis, Primary, 2:

Name: Biliary Cirrhosis, Primary, 2 58 13 74
Pbc2 58

Classifications:



External Ids:

OMIM 58 613007
MedGen 43 C2751696
UMLS 74 C2751696

Summaries for Biliary Cirrhosis, Primary, 2

OMIM : 58 Primary biliary cirrhosis (PBC) is a chronic, progressive cholestatic liver disease that usually affects middle-aged women and eventually leads to liver failure (summary by Kaplan, 1996). For a discussion of genetic heterogeneity of primary biliary cirrhosis (PBC), see PBC1 (109720). (613007)

MalaCards based summary : Biliary Cirrhosis, Primary, 2, also known as pbc2, is related to primary biliary cirrhosis and biliary cirrhosis, primary, 1. An important gene associated with Biliary Cirrhosis, Primary, 2 is PBC2 (Biliary Cirrhosis, Primary, 2). The drugs Atorvastatin and Hydroxymethylglutaryl-CoA Reductase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include liver.

Related Diseases for Biliary Cirrhosis, Primary, 2

Diseases in the Primary Biliary Cirrhosis family:

Biliary Cirrhosis, Primary, 1 Biliary Cirrhosis, Primary, 2
Biliary Cirrhosis, Primary, 3 Biliary Cirrhosis, Primary, 4
Biliary Cirrhosis, Primary, 5

Diseases related to Biliary Cirrhosis, Primary, 2 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 primary biliary cirrhosis 11.5
2 biliary cirrhosis, primary, 1 10.1
3 primary biliary cholangitis 10.1

Symptoms & Phenotypes for Biliary Cirrhosis, Primary, 2

Clinical features from OMIM:

613007

Drugs & Therapeutics for Biliary Cirrhosis, Primary, 2

Drugs for Biliary Cirrhosis, Primary, 2 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Atorvastatin Approved Phase 3 134523-00-5 60823
2 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 3
3 Antimetabolites Phase 3
4 Hypolipidemic Agents Phase 3
5 Anticholesteremic Agents Phase 3
6 Lipid Regulating Agents Phase 3
7
Ursodeoxycholic acid Approved, Investigational 128-13-2 31401
8 Immunologic Factors
9 Antibodies
10 Gastrointestinal Agents
11 Immunoglobulins, Intravenous
12 gamma-Globulins
13 Cholagogues and Choleretics
14 Rho(D) Immune Globulin
15 Immunoglobulins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Long-Term Treatment With Atorvastatin in Patients With Primary Biliary Cirrhosis Completed NCT00844402 Phase 3 Atorvastatin
2 The Comparison About the Response of Ursodeoxycholic Acid in Primary Biliary Cholangitis Only and Primary Biliary Cholangitis With High Immune Globulin G or Aminotransferase at West China Hospital Completed NCT03322943

Search NIH Clinical Center for Biliary Cirrhosis, Primary, 2

Genetic Tests for Biliary Cirrhosis, Primary, 2

Anatomical Context for Biliary Cirrhosis, Primary, 2

MalaCards organs/tissues related to Biliary Cirrhosis, Primary, 2:

42
Liver

Publications for Biliary Cirrhosis, Primary, 2

Articles related to Biliary Cirrhosis, Primary, 2:

# Title Authors Year
1
Evidence that rabbit cytochrome P-450 K is encoded by the plasmid pP-450 PBc2. ( 3801023 )
1986

Variations for Biliary Cirrhosis, Primary, 2

Expression for Biliary Cirrhosis, Primary, 2

Search GEO for disease gene expression data for Biliary Cirrhosis, Primary, 2.

Pathways for Biliary Cirrhosis, Primary, 2

GO Terms for Biliary Cirrhosis, Primary, 2

Sources for Biliary Cirrhosis, Primary, 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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