Biliary Cirrhosis, Primary, 2 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Biliary Cirrhosis, Primary, 2

MalaCards integrated aliases for Biliary Cirrhosis, Primary, 2:

Name: Biliary Cirrhosis, Primary, 2 ⁵⁷ ¹³ ⁷³

Pbc2 ⁵⁷

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases Immune diseases Endocrine diseases Liver diseases

See all MalaCards categories (disease lists)

External Ids:

OMIM ⁵⁷ 613007

MedGen ⁴² C2751696

UMLS ⁷³ C2751696

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Summaries for Biliary Cirrhosis, Primary, 2

OMIM : ⁵⁷ Primary biliary cirrhosis (PBC) is a chronic, progressive cholestatic liver disease that usually affects middle-aged women and eventually leads to liver failure (summary by Kaplan, 1996). For a discussion of genetic heterogeneity of primary biliary cirrhosis (PBC), see PBC1 (109720). (613007)

MalaCards based summary : Biliary Cirrhosis, Primary, 2, also known as pbc2, is related to primary biliary cirrhosis and biliary cirrhosis, primary, 1. An important gene associated with Biliary Cirrhosis, Primary, 2 is PBC2 (Biliary Cirrhosis, Primary, 2). The drugs Lipid Regulating Agents and Hypolipidemic Agents have been mentioned in the context of this disorder. Affiliated tissues include liver.

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Related Diseases for Biliary Cirrhosis, Primary, 2

Diseases in the Primary Biliary Cirrhosis family:

Biliary Cirrhosis, Primary, 1	Biliary Cirrhosis, Primary, 2
Biliary Cirrhosis, Primary, 3	Biliary Cirrhosis, Primary, 4
Biliary Cirrhosis, Primary, 5

Diseases related to Biliary Cirrhosis, Primary, 2 via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score
1	primary biliary cirrhosis	11.4
2	biliary cirrhosis, primary, 1	10.1
3	primary biliary cholangitis	10.1

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Symptoms & Phenotypes for Biliary Cirrhosis, Primary, 2

Clinical features from OMIM:

613007

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Drugs & Therapeutics for Biliary Cirrhosis, Primary, 2

Drugs for Biliary Cirrhosis, Primary, 2 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Lipid Regulating Agents

Phase 3

2

Hypolipidemic Agents

Phase 3

3

Atorvastatin Calcium

Phase 3

134523-03-8

4

Hydroxymethylglutaryl-CoA Reductase Inhibitors

Phase 3

5

Calcium, Dietary

Phase 3

6

Anticholesteremic Agents

Phase 3

7

Antimetabolites

Phase 3

8

Ursodeoxycholic acid

Approved, Investigational

128-13-2

31401

Synonyms:

(3a,5b,7b)-3,7-Dihydroxycholan-24-Oate

(3a,5b,7b)-3,7-Dihydroxy-cholan-24-Oate

(3a,5b,7b)-3,7-Dihydroxycholan-24-Oic acid

(3a,5b,7b)-3,7-Dihydroxy-cholan-24-Oic acid

(3alpha,5beta,7beta)-3,7-Dihydroxycholan-24-Oate

(3alpha,5beta,7beta)-3,7-dihydroxycholan-24-oic acid

(3alpha,5beta,7beta)-3,7-Dihydroxycholan-24-Oic acid

(3alpha,5beta,7beta,8xi)-3,7-dihydroxycholan-24-oic acid

(3α,5β,7β)-3,7-dihydroxycholan-24-Oate

(3α,5β,7β)-3,7-dihydroxycholan-24-oic acid

(3α,5β,7β)-3,7-dihydroxycholan-24-Oic acid

(4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid

128-13-2

17-beta-(1-Methyl-3-carboxypropyl)etiocholane-3-alpha,7-beta-diol

3 alpha,7 beta Dihydroxy 5 beta cholan 24 Oic acid

3 alpha,7 beta-Dihydroxy-5 beta-cholan-24-oic Acid

3 alpha,7 beta-Dihydroxy-5 beta-cholan-24-Oic acid

3,7-Dihydroxycholan-24-oic acid

3,7-Dihydroxycholan-24-Oic acid

3a,7b-Dihydroxy-5b-cholan-24-Oate

3a,7b-Dihydroxy-5b-cholan-24-Oic acid

3alpha,7beta-Dihydroxy-5beta-cholan-24-Oate

3alpha,7beta-Dihydroxy-5beta-cholan-24-oic acid

3alpha,7beta-Dihydroxy-5beta-cholan-24-Oic acid

3alpha,7beta-Dihydroxy-5beta-cholanic acid

3-alpha,7-beta-Dihydroxy-5-beta-cholanoic acid

3-alpha,7-beta-Dihydroxycholanic acid

3-alpha,7-beta-Dioxycholanic acid

3α,7β-dihydroxy-5β-cholan-24-Oate

3α,7β-dihydroxy-5β-cholan-24-Oic acid

4-10-00-01604 (Beilstein Handbook Reference)

50809-41-1

5beta-Cholan-24-oic acid-3alpha,7beta-diol

5beta-Cholanic Acid-3alpha,7beta-diol

7beta-Hydroxylithocholic acid

7-beta-Hydroxylithocholic acid

80225-86-1

AB00513977

AC-18919

AC1L1LJH

AC-2081

Acid, deoxyursocholic

Acid, ursacholic

Acid, ursodeoxycholic

Acide ursodesoxycholique

Acide ursodesoxycholique [INN-French]

Acido ursodeossicolico

Acido ursodeossicolico [Italian]

Acido ursodeoxicolico

Acido ursodeoxicolico [INN-Spanish]

Acidum ursodeoxycholicum

Acidum ursodeoxycholicum [INN-Latin]

Actigall

Actigall (TN)

Antigall

Antigen brand OF ursodeoxycholic acid

Arsacol

Aventis brand OF ursodeoxycholic acid

Axcan brand OF ursodeoxycholic acid

BB_NC-2372

BPBio1_001052

BRN 3219888

BSPBio_000956

C07880

C24H40O4

CCRIS 5502

CHEBI:9907

CHEMBL1551

CHEMBL73390

chenodeoxycholic acid

Cholan-24-oic acid, 3,7-dihydroxy-, (3-alpha,5-beta,7-beta)- (9CI)

Cholit-ursan

Cholofalk

CID11516715

CID31401

CP Brand OF ursodeoxycholic acid

CPD000058403

CPD-10534

D00734

DB01586

Delursan

Deoxyursocholic acid

Deoxyursocholic Acid

Destolit

Deursil

Dom-ursodiol c

EINECS 204-879-3

Estedi brand OF ursodeoxycholic acid

Falk brand OF ursodeoxycholic acid

Farmasa brand OF ursodeoxycholic acid

Galen brand OF ursodeoxycholic acid

Heumann brand OF ursodeoxycholic acid

HMS1570P18

ISO-URSODEOXYCHOLIC ACID

IU5

Litursol

LMST04010033

LS-53033

Lyeton

MLS000028461

MLS001066373

MolPort-001-794-630

MolPort-005-932-884

NCGC00179363-01

NCI60_028904

Niddapharm brand OF ursodeoxycholic acid

Norgine brand OF ursodeoxycholic acid

NSC 657950

NSC 683769

Orphan brand OF ursodeoxycholic acid

Peptarom

PHL-ursodiol c

PMS-ursodiol c

Prestwick0_000958

Prestwick1_000958

Prestwick2_000958

Prestwick3_000958

Provalis brand OF ursodeoxycholic acid

S1643_Selleck

SAM002264653

Sanofi synthelabo brand OF ursodeoxycholic acid

SMP2_000012

SMR000058403

Sodium ursodeoxycholate

Sodium Ursodeoxycholate

Solutrat

SPBio_003105

tramedico Brand OF ursodeoxycholic acid

U0030

U5127_SIGMA

U-9000

UDCA

UDCS

UNII-724L30Y2QR

Urdox

Urosdesoxycholate

Urosdesoxycholic acid

Urosiol

Ursacholic acid

Ursacholic Acid

Ursacol

Urso

UrSO

Urso (TN)

Urso 250

Urso DS

Urso Forte

urso Heumann

Ursobilane

Ursobilin

Ursochol

Ursodamor

Ursodeoxy cholic acid

ursodeoxycholate

Ursodeoxycholate

Ursodeoxycholate, sodium

Ursodeoxycholic acid

URSODEOXYCHOLIC ACID

Ursodeoxycholic acid (JP15/INN)

Ursodeoxycholic acid, UDCA, Ursosan, Ursofalk, Urso Forte, Udiliv, Ursodiol

Ursodeoxycholicacid

Ursodesoxycholic acid

Ursodexycholate

Ursodexycholic acid

Ursodexycholic Acid

ursodiol

Ursodiol

Ursodiol (USP)

Ursodiol [USAN]

Ursofalk

Ursogal

Ursolite

Ursolvan

Ursosan

Vita brand OF ursodeoxycholic acid

Zambon brand OF ursodeoxycholic acid

9

Immunoglobulins, Intravenous

10

Antibodies

11

Gastrointestinal Agents

12

gamma-Globulins

13

Immunoglobulins

14

Cholagogues and Choleretics

15

Immunologic Factors

16

Rho(D) Immune Globulin

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Safety and Efficacy of Long-Term Treatment With Atorvastatin in Patients With Primary Biliary Cirrhosis	Completed	NCT00844402	Phase 3	Atorvastatin
2	The Comparison About the Response of Ursodeoxycholic Acid in Primary Biliary Cholangitis Only and Primary Biliary Cholangitis With High Immune Globulin G or Aminotransferase at West China Hospital	Recruiting	NCT03322943

Search NIH Clinical Center for Biliary Cirrhosis, Primary, 2

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Genetic Tests for Biliary Cirrhosis, Primary, 2

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Anatomical Context for Biliary Cirrhosis, Primary, 2

MalaCards organs/tissues related to Biliary Cirrhosis, Primary, 2:

⁴¹

Liver

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Publications for Biliary Cirrhosis, Primary, 2

Articles related to Biliary Cirrhosis, Primary, 2:

#	Title	Authors	Year
1	Evidence that rabbit cytochrome P-450 K is encoded by the plasmid pP-450 PBc2. ( 3801023 )	Finlayson MJ...Johnson EF	1986

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Genes for Biliary Cirrhosis, Primary, 2

Genes related to Biliary Cirrhosis, Primary, 2 (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	PBC2	Biliary Cirrhosis, Primary, 2	Genetic Locus	58.69	Susceptibility factor ⁵⁷ GeneCards inferred via : Gene name (show sections)

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Variations for Biliary Cirrhosis, Primary, 2

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Expression for Biliary Cirrhosis, Primary, 2

Search GEO for disease gene expression data for Biliary Cirrhosis, Primary, 2.

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Pathways for Biliary Cirrhosis, Primary, 2

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GO Terms for Biliary Cirrhosis, Primary, 2

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Sources for Biliary Cirrhosis, Primary, 2

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia

Biliary Cirrhosis, Primary, 2 (PBC2)

Aliases & Classifications for Biliary Cirrhosis, Primary, 2

MalaCards integrated aliases for Biliary Cirrhosis, Primary, 2:

Classifications:

External Ids:

Summaries for Biliary Cirrhosis, Primary, 2

Related Diseases for Biliary Cirrhosis, Primary, 2

Diseases in the Primary Biliary Cirrhosis family:

Diseases related to Biliary Cirrhosis, Primary, 2 via text searches within MalaCards or GeneCards Suite gene sharing:

Symptoms & Phenotypes for Biliary Cirrhosis, Primary, 2

Clinical features from OMIM:

Drugs & Therapeutics for Biliary Cirrhosis, Primary, 2

Drugs for Biliary Cirrhosis, Primary, 2 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Genetic Tests for Biliary Cirrhosis, Primary, 2

Anatomical Context for Biliary Cirrhosis, Primary, 2

MalaCards organs/tissues related to Biliary Cirrhosis, Primary, 2:

Publications for Biliary Cirrhosis, Primary, 2

Articles related to Biliary Cirrhosis, Primary, 2:

Genes for Biliary Cirrhosis, Primary, 2

Genes related to Biliary Cirrhosis, Primary, 2 (1 elite genes):

Variations for Biliary Cirrhosis, Primary, 2

Expression for Biliary Cirrhosis, Primary, 2

Pathways for Biliary Cirrhosis, Primary, 2

GO Terms for Biliary Cirrhosis, Primary, 2

Sources for Biliary Cirrhosis, Primary, 2