PBC3
MCID: BLR017
MIFTS: 12

Biliary Cirrhosis, Primary, 3 (PBC3)

Categories: Endocrine diseases, Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Biliary Cirrhosis, Primary, 3

MalaCards integrated aliases for Biliary Cirrhosis, Primary, 3:

Name: Biliary Cirrhosis, Primary, 3 58 13 74
Pbc3 58

Classifications:



External Ids:

OMIM 58 613008
MedGen 43 C2751695
UMLS 74 C2751695

Summaries for Biliary Cirrhosis, Primary, 3

OMIM : 58 Primary biliary cirrhosis (PBC) is a chronic, progressive cholestatic liver disease that usually affects middle-aged women and eventually leads to liver failure (summary by Kaplan, 1996). For a discussion of genetic heterogeneity of primary biliary cirrhosis (PBC), see PBC1 (109720). (613008)

MalaCards based summary : Biliary Cirrhosis, Primary, 3, also known as pbc3, is related to primary biliary cirrhosis. An important gene associated with Biliary Cirrhosis, Primary, 3 is PBC3 (Biliary Cirrhosis, Primary, 3). The drug Ursodeoxycholic acid has been mentioned in the context of this disorder. Affiliated tissues include liver.

Related Diseases for Biliary Cirrhosis, Primary, 3

Diseases in the Primary Biliary Cirrhosis family:

Biliary Cirrhosis, Primary, 1 Biliary Cirrhosis, Primary, 2
Biliary Cirrhosis, Primary, 3 Biliary Cirrhosis, Primary, 4
Biliary Cirrhosis, Primary, 5

Diseases related to Biliary Cirrhosis, Primary, 3 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 primary biliary cirrhosis 11.1

Symptoms & Phenotypes for Biliary Cirrhosis, Primary, 3

Clinical features from OMIM:

613008

Drugs & Therapeutics for Biliary Cirrhosis, Primary, 3

Drugs for Biliary Cirrhosis, Primary, 3 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ursodeoxycholic acid Approved, Investigational Phase 4 128-13-2 31401

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Trial of 18-22mg/kg/d Ursodeoxycholic in Refractory Primary Biliary Cholangitis Recruiting NCT03345589 Phase 4 18-22mg/kg/d Ursodeoxycholic;13-15mg/kg/d Ursodeoxycholic

Search NIH Clinical Center for Biliary Cirrhosis, Primary, 3

Genetic Tests for Biliary Cirrhosis, Primary, 3

Anatomical Context for Biliary Cirrhosis, Primary, 3

MalaCards organs/tissues related to Biliary Cirrhosis, Primary, 3:

42
Liver

Publications for Biliary Cirrhosis, Primary, 3

Variations for Biliary Cirrhosis, Primary, 3

Expression for Biliary Cirrhosis, Primary, 3

Search GEO for disease gene expression data for Biliary Cirrhosis, Primary, 3.

Pathways for Biliary Cirrhosis, Primary, 3

GO Terms for Biliary Cirrhosis, Primary, 3

Sources for Biliary Cirrhosis, Primary, 3

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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