MCID: BLR004
MIFTS: 33

Biliary Dyskinesia

Categories: Gastrointestinal diseases

Aliases & Classifications for Biliary Dyskinesia

MalaCards integrated aliases for Biliary Dyskinesia:

Name: Biliary Dyskinesia 12 55 44 15 73
Sphincter of Oddi Dysfunction 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4140
MeSH 44 D001657
SNOMED-CT 68 43469007
UMLS 73 C0005416

Summaries for Biliary Dyskinesia

Disease Ontology : 12 A gallbladder disease characterized by altered tonus of the sphincter of Oddi, disturbance in the coordination of contraction of the biliary ducts, and/or reduction in the speed of emptying of the biliary tree.

MalaCards based summary : Biliary Dyskinesia, also known as sphincter of oddi dysfunction, is related to acute pancreatitis and choledocholithiasis. An important gene associated with Biliary Dyskinesia is CCK (Cholecystokinin), and among its related pathways/superpathways is Gastric acid production. The drugs Pinaverium and Morphine have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and pancreas.

Wikipedia : 76 Biliary dyskinesia is a disorder of some component of biliary part of the digestive system in which bile... more...

Related Diseases for Biliary Dyskinesia

Diseases related to Biliary Dyskinesia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
# Related Disease Score Top Affiliating Genes
1 acute pancreatitis 30.5 CCK SCT
2 choledocholithiasis 30.0 SOBP STK10
3 duodenogastric reflux 30.0 CCK SCT
4 pancreatitis 29.9 CCK SCT
5 recurrent acute pancreatitis 10.4
6 segmental odontomaxillary dysplasia 10.3
7 bile duct cysts 10.3
8 degos 'en cocarde' erythrokeratoderma 10.3
9 cholecystitis 10.1
10 paine syndrome 10.1
11 somatization disorder 10.1
12 fascioliasis 10.1
13 achalasia 10.1
14 irritable bowel syndrome 10.1
15 fibromyalgia 10.1
16 pain - chronic 10.1
17 swallowing disorders 10.1
18 pancreatic cholera 10.1 CCK SCT
19 pancreatic steatorrhea 10.1 CCK SCT
20 steatorrhea 10.1 CCK SCT
21 duodenal disease 10.1 CCK SCT
22 postcholecystectomy syndrome 10.1 CCK SOBP
23 duodenal gastrinoma 10.1 CCK SCT
24 space motion sickness 10.1 CCK SCT
25 exocrine pancreatic insufficiency 10.1 CCK SCT
26 alcoholic pancreatitis 10.0 CCK SCT
27 cholelithiasis 10.0
28 gastroparesis 10.0
29 acalculous cholecystitis 10.0
30 cholecystolithiasis 10.0 CCK STK10
31 maturity-onset diabetes of the young, type 7 10.0 CCK SCT
32 duodenal ulcer 10.0 CCK SCT
33 pancreas disease 10.0 CCK SCT
34 gastrointestinal system disease 9.9 CCK SCT
35 dermatitis, atopic 9.9
36 urticaria 9.9
37 constipation 9.9
38 dermatitis 9.9
39 causalgia 9.9
40 cholangitis 9.9
41 carotenemia 9.9
42 common bile duct disease 9.8 CCK SOBP STK10
43 panic disorder 9.8 CCK TSPO

Graphical network of the top 20 diseases related to Biliary Dyskinesia:



Diseases related to Biliary Dyskinesia

Symptoms & Phenotypes for Biliary Dyskinesia

Drugs & Therapeutics for Biliary Dyskinesia

Drugs for Biliary Dyskinesia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pinaverium Approved Phase 4 59995-65-2
2
Morphine Approved, Investigational Phase 4 57-27-2 5288826
3
Secretin Approved Phase 4 108153-74-8
4
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
5 Anticonvulsants Phase 4
6 Autonomic Agents Phase 4
7 Parasympatholytics Phase 4
8 Calcium, Dietary Phase 4
9 calcium channel blockers Phase 4
10 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
11 Bromides Phase 4
12 Analgesics Phase 4,Phase 3,Phase 2
13 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
14 Central Nervous System Depressants Phase 4,Phase 2,Not Applicable
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
16 Cholinesterase Inhibitors Phase 4
17 Cholinergic Agents Phase 4
18 Analgesics, Opioid Phase 4
19 Hormone Antagonists Phase 4
20 Narcotics Phase 4
21 Hormones Phase 4
22 Gastrointestinal Agents Phase 4
23
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
24
Norepinephrine Approved Phase 3 51-41-2 439260
25 Psychotropic Drugs Phase 3,Phase 2
26 Neurotransmitter Uptake Inhibitors Phase 3,Phase 2
27 Antidepressive Agents Phase 3,Phase 2
28 Dopamine Agents Phase 3
29 Serotonin and Noradrenaline Reuptake Inhibitors Phase 3
30 Duloxetine Hydrochloride Phase 3
31
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
32
Amitriptyline Approved Phase 2 50-48-6 2160
33
Perphenazine Approved Phase 2 58-39-9 4748
34 Amitriptyline, perphenazine drug combination Phase 2
35 Analgesics, Non-Narcotic Phase 2
36 Antidepressive Agents, Tricyclic Phase 2
37 Adrenergic Agents Phase 2
38 Tranquilizing Agents Phase 2
39 Antipsychotic Agents Phase 2
40
Ropivacaine Approved Not Applicable 84057-95-4 175805 71273
41
Bupivacaine Approved, Investigational Not Applicable 2180-92-9, 38396-39-3 2474
42 Anesthetics, Local Not Applicable
43 Anesthetics Not Applicable

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Pinaverium Bromide in Post-cholecystectomy Sphincter of Oddi Dysfunction Unknown status NCT02833103 Phase 4 Danshu Capsules;Pinaverium Bromide
2 A Study of Serial Magnetic Resonance Cholangiopancreatography (MRCP) Following Morphine-neostigmine and Secretin Provocation in Healthy Volunteers Completed NCT01134848 Phase 4 Morphine;Neostigmine;0.9% saline;Secretin;0.9% saline
3 Duloxetine in Patients With Suspected Functional Pancreatic/Biliary Pain (Sphincter of Oddi Dysfunction) Completed NCT00471315 Phase 3 Duloxetine
4 Trial of Laparoscopic Cholecystectomy vs. Non-operative Treatment for Gallbladder Dyskinesia Unknown status NCT02195115 Phase 2 amitriptyline
5 Transvaginal Cholecystectomy Using Endoscopic Assistance Withdrawn NCT00815438 Phase 1
6 Natural Orifice Translumenal Endoscopic Surgery (NOTES) Transvaginal Cholecystectomy Completed NCT00984100 Not Applicable
7 Single Incision Laparoscopic Surgery (SILS) Versus Laparoscopic Cholecystectomy Completed NCT00981604 Not Applicable
8 Primary Needle Knife Fistulotomy Versus Conventional Cannulation Method Completed NCT02916199 Not Applicable
9 Evaluating Predictors & Interventions in Sphincter of Oddi Dysfunction Completed NCT00688662 Not Applicable
10 The Clinical Evaluation of Oddi Spincteroplasty With Blood Vessel Clamp After Iatrogenic Injury by ERCP Recruiting NCT03795584 Not Applicable
11 Trans-incisional vs Laparoscopic Guided Rectus Sheath Block for Pediatric Single Incision Laparoscopic Cholecystectomy Active, not recruiting NCT02494336 Not Applicable Ropivacaine
12 Ultrasound for Diagnosis of Biliary Dyskinesia Terminated NCT00737295 Not Applicable
13 Single-Incision Laparoscopic Cholecystectomy Versus Traditional Laparoscopic Cholecystectomy Terminated NCT01195285 Not Applicable
14 Evaluation of Gastrointestinal Symptoms and Quality of Life in Patients With Sphincter of Oddi Dysfunction Terminated NCT01410071

Search NIH Clinical Center for Biliary Dyskinesia

Cochrane evidence based reviews: biliary dyskinesia

Genetic Tests for Biliary Dyskinesia

Anatomical Context for Biliary Dyskinesia

MalaCards organs/tissues related to Biliary Dyskinesia:

41
Testes, Liver, Pancreas, Spinal Cord

Publications for Biliary Dyskinesia

Articles related to Biliary Dyskinesia:

(show top 50) (show all 301)
# Title Authors Year
1
Poor Reproducibility of Gallbladder Ejection Fraction by Biliary Scintigraphy for Diagnosis of Biliary Dyskinesia. ( 29157795 )
2018
2
Trends of Cholecystectomies for Presumed Biliary Dyskinesia in Children in the United States. ( 29036007 )
2018
3
Long-term results of cholecystectomy for biliary dyskinesia: outcomes and resource utilization. ( 30100038 )
2018
4
Pathologic Findings of the Gallbladder in Patients Undergoing Surgery for Biliary Dyskinesia. ( 30219129 )
2018
5
Pediatric Biliary Dyskinesia: Evaluating Predictive Factors for Successful Treatment of Biliary Dyskinesia with Laparoscopic Cholecystectomy. ( 30268165 )
2018
6
Pathologic Findings of the Gallbladder in Patients Undergoing Surgery for Biliary Dyskinesia. ( 30454529 )
2018
7
Cost Effective Therapy for Sphincter of Oddi Dysfunction. ( 28711688 )
2018
8
Sphincter of Oddi dysfunction: the never-ending story has come to a conclusion. ( 29241851 )
2018
9
Sphincter of Oddi dysfunction: sphincter of Oddi dysfunction or discordance? What is the state of the art in 2018? ( 29916850 )
2018
10
Post-ERCP biliary complications in patients with biliary type sphincter of Oddi dysfunction. ( 29967373 )
2018
11
Decision-making patterns in managing children with suspected biliary dyskinesia. ( 28540197 )
2017
12
Gallbladder Dysfunction: Cholecystitis, Choledocholithiasis, Cholangitis, and Biliary Dyskinesia. ( 29132521 )
2017
13
Outcomes of Laparoscopic Cholecystectomy for Biliary Dyskinesia in Children. ( 28350202 )
2017
14
Effects of laparoscopic cholecystectomy in normokinetic biliary dyskinesia. ( 28669533 )
2017
15
Outcomes of Endoscopic Retrograde Cholangiopancreatography (ERCP) and Sphincterotomy for Suspected Sphincter of Oddi Dysfunction (SOD) Post Roux-En-Y Gastric Bypass. ( 28488091 )
2017
16
Risk factors of post- endoscopic retrograde cholangiopancreatography pancreatitis in biliary type sphincter of Oddi dysfunction in Japanese patients. ( 28898571 )
2017
17
Biliary Dyskinesia in Children: A Systematic Review. ( 27472474 )
2016
18
The Utility of Nuclear Medicine Scans for Diagnosing Pediatric Biliary Dyskinesia Remains Unclear. ( 27149253 )
2016
19
Management of Sphincter of Oddi Dysfunction: Teaching an Old SOD New Tricks? ( 27435328 )
2016
20
Duloxetine for the Treatment of Patients with Suspected Sphincter of Oddi Dysfunction: A Pilot Study. ( 27165434 )
2016
21
Opium-related sphincter of Oddi dysfunction causing double duct sign. ( 27503161 )
2016
22
Translational and clinical perspectives on sphincter of Oddi dysfunction. ( 27555792 )
2016
23
Wide disparities in attitudes and practices regarding Type II sphincter of Oddi dysfunction: a survey of expert U.S. endoscopists. ( 27652298 )
2016
24
Post-cholecystectomy syndrome and sphincter of Oddi dysfunction: past, present and future. ( 27762149 )
2016
25
Sphincter of Oddi Dysfunction: A Perplexing Presentation. ( 28100991 )
2016
26
Prediction of symptom improvement in children with biliary dyskinesia. ( 25891671 )
2015
27
In response to: Preston JF, Diggs BS, Dolan JP, Gilbert EW, Schein M, Hunter JG. Biliary dyskinesia: a surgical disease rarely found outside the United States. Am J Surg. 2015;209:799-803. ( 26116320 )
2015
28
Biliary dyskinesia: a surgical disease rarely found outside the United States. ( 25771131 )
2015
29
HIDA Scan with Ejection Fraction Is over Utilized in the Management of Biliary Dyskinesia. ( 26140885 )
2015
30
Endoscopic sphincterotomy for sphincter of oddi dysfunction: inefficacious therapy for a fictitious disease. ( 25532810 )
2015
31
Spinal cord stimulation for intractable visceral pain due to sphincter of oddi dysfunction. ( 25589948 )
2015
32
A Trial of Rectal Indomethacin to Prevent Post-ERCP Pancreatitis in Patients with Suspected Type 3 Sphincter of Oddi Dysfunction. ( 25868629 )
2015
33
Determinants of long-term complications of endoscopic sphincterotomy are infections and high risk factors of bile duct and not sphincter of Oddi dysfunction. ( 25874514 )
2015
34
Sphincter of Oddi dysfunction Type III: New studies suggest new approaches are needed. ( 26019439 )
2015
35
Sphincter of Oddi Dysfunction: Updates from the Recent Literature. ( 26143628 )
2015
36
Incidence and predictors of post-ERCP pancreatitis in patients with suspected sphincter of Oddi dysfunction undergoing biliary or dual sphincterotomy: results from the EPISOD prospective multicenter randomized sham-controlled study. ( 26165739 )
2015
37
Sphincter of Oddi Dysfunction. ( 26431602 )
2015
38
Erratum to: A Trial of Rectal Indomethacin to Prevent Post-ERCP Pancreatitis in Patients with Suspected Type 3 Sphincter of Oddi Dysfunction. ( 26438337 )
2015
39
Acalculous cholecystitis or biliary dyskinesia for Epstein-Barr virus gallbladder involvement? ( 24874936 )
2014
40
Osteopathic manipulative treatment in the management of biliary dyskinesia. ( 24481806 )
2014
41
Biliary dyskinesia in pediatrics. ( 24716563 )
2014
42
Cholecystectomy for biliary dyskinesia in gastroparesis: mimic or misfortune? ( 25502153 )
2014
43
Long-term efficacy of laparoscopic cholecystectomy for the treatment of biliary dyskinesia. ( 24581761 )
2014
44
Biliary dyskinesia and symptomatic gallstone disease in children: two sides of the same coin? ( 24715545 )
2014
45
Commentary on "Cholecystectomy for biliary dyskinesia in gastroparesis: mimic or misfortune?". ( 25502154 )
2014
46
Cholecystectomy for biliary dyskinesia: how did we get there? ( 25193389 )
2014
47
Psychosocial characteristics and pain burden of patients with suspected sphincter of Oddi dysfunction in the EPISOD multicenter trial. ( 24445573 )
2014
48
Can patient and pain characteristics predict manometric sphincter of Oddi dysfunction in patients with clinically suspected sphincter of Oddi dysfunction? ( 24472759 )
2014
49
Impact of pancreatic stent caliber on post-endoscopic retrograde cholangiopancreatogram pancreatitis rates in patients with confirmed sphincter of Oddi dysfunction. ( 24617703 )
2014
50
Effect of endoscopic sphincterotomy for suspected sphincter of Oddi dysfunction on pain-related disability following cholecystectomy: the EPISOD randomized clinical trial. ( 24867013 )
2014

Variations for Biliary Dyskinesia

Expression for Biliary Dyskinesia

Search GEO for disease gene expression data for Biliary Dyskinesia.

Pathways for Biliary Dyskinesia

Pathways related to Biliary Dyskinesia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.47 CCK SCT

GO Terms for Biliary Dyskinesia

Biological processes related to Biliary Dyskinesia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of mitochondrial depolarization GO:0051901 8.62 CCK TSPO

Molecular functions related to Biliary Dyskinesia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.62 CCK SCT

Sources for Biliary Dyskinesia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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