MCID: BLR004
MIFTS: 37

Biliary Dyskinesia

Categories: Gastrointestinal diseases

Aliases & Classifications for Biliary Dyskinesia

MalaCards integrated aliases for Biliary Dyskinesia:

Name: Biliary Dyskinesia 12 54 43 15 17 71
Sphincter of Oddi Dysfunction 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4140
MeSH 43 D001657
SNOMED-CT 67 43469007
UMLS 71 C0005416

Summaries for Biliary Dyskinesia

Disease Ontology : 12 A gallbladder disease characterized by altered tonus of the sphincter of Oddi, disturbance in the coordination of contraction of the biliary ducts, and/or reduction in the speed of emptying of the biliary tree.

MalaCards based summary : Biliary Dyskinesia, also known as sphincter of oddi dysfunction, is related to bile duct cysts and acalculous cholecystitis. An important gene associated with Biliary Dyskinesia is CCK (Cholecystokinin), and among its related pathways/superpathways are Salivary secretion and Pancreatic secretion. The drugs Pinaverium and Secretin have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and testes.

Wikipedia : 74 Biliary dyskinesia is a disorder of some component of biliary part of the digestive system in which bile... more...

Related Diseases for Biliary Dyskinesia

Diseases related to Biliary Dyskinesia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 199)
# Related Disease Score Top Affiliating Genes
1 bile duct cysts 30.9 PRSS1 GPT
2 acalculous cholecystitis 30.9 GPT CCK
3 cholelithiasis 30.9 SST GPT CCK
4 recurrent acute pancreatitis 30.8 SPINK1 SCT PRSS1 CFTR
5 gastritis 30.5 SST SCT ATP4A
6 postcholecystectomy syndrome 30.5 SOBP CCK
7 duodenal ulcer 30.4 SST SCT CCK
8 cholecystolithiasis 30.4 GPT CCK
9 gastroduodenitis 30.2 ATP4A ATP12A
10 dumping syndrome 30.2 SST SCT CCK
11 choledocholithiasis 30.2 GPT CCK
12 peptic esophagitis 30.1 ATP4A ATP12A
13 hernia, hiatus 30.1 ATP4A ATP12A
14 constipation 30.1 SST CCK ATP4A ATP12A
15 gallbladder disease 30.0 SST GPT CFTR CCK
16 pancreatitis, hereditary 30.0 SPINK1 PRSS1 CFTR
17 peptic ulcer disease 29.8 SST SCT ATP4A ATP12A
18 cholangitis 29.6 SST GPT CFTR
19 duodenogastric reflux 29.6 SST SCT CCK ATP4A ATP12A
20 pancreatitis 29.4 SST SPINK1 SCT REG3A PRSS1 CFTR
21 acute pancreatitis 28.7 SST SPINK1 SCT REG3A PRSS1 GPT
22 cholecystitis 10.6
23 gallbladder disease 1 10.5
24 pancreatic cholera 10.4 SST SCT
25 functionless pituitary adenoma 10.4 SST CCK
26 glucagonoma 10.4 SST SCT
27 tropical calcific pancreatitis 10.4 SPINK1 PRSS1
28 pancreas, annular 10.4 SPINK1 PRSS58
29 dysplastic nevus syndrome 10.3 PRSS58 PRSS1
30 parenteral nutrition-associated cholestasis 10.3 GPT CCK
31 pancreatic vasoactive intestinal peptide producing tumor 10.3 ATP4A ATP12A
32 hemangioma of intra-abdominal structure 10.3 ATP4A ATP12A
33 displacement of cardia through esophageal hiatus 10.3 ATP4A ATP12A
34 acquired gastric outlet stenosis 10.3 ATP4A ATP12A
35 angiodysplasia of intestine 10.3 ATP4A ATP12A
36 benzylpenicillin allergy 10.3 ATP4A ATP12A
37 median arcuate ligament syndrome 10.3 ATP4A ATP12A
38 granulomatous gastritis 10.3 ATP4A ATP12A
39 bacterial esophagitis 10.3 ATP4A ATP12A
40 lingual goiter 10.3 ATP4A ATP12A
41 cascade stomach 10.3 ATP4A ATP12A
42 gastrojejunal ulcer 10.3 ATP4A ATP12A
43 optic papillitis 10.3
44 fungal esophagitis 10.3 ATP4A ATP12A
45 gastric gastrinoma 10.3 ATP4A ATP12A
46 fungal gastritis 10.3 ATP4A ATP12A
47 superior mesenteric artery syndrome 10.3 ATP4A ATP12A
48 pneumatosis cystoides intestinalis 10.3 ATP4A ATP12A
49 dieulafoy lesion 10.3 ATP4A ATP12A
50 esophagus sarcoma 10.3 ATP4A ATP12A

Graphical network of the top 20 diseases related to Biliary Dyskinesia:



Diseases related to Biliary Dyskinesia

Symptoms & Phenotypes for Biliary Dyskinesia

Drugs & Therapeutics for Biliary Dyskinesia

Drugs for Biliary Dyskinesia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 52)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pinaverium Approved Phase 4 59995-65-2
2
Secretin Approved Phase 4 108153-74-8
3
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
4
Morphine Approved, Investigational Phase 4 57-27-2 5288826
5 Anticonvulsants Phase 4
6 calcium channel blockers Phase 4
7 Parasympatholytics Phase 4
8 Bromides Phase 4
9 Autonomic Agents Phase 4
10 Hormones Phase 4
11 Analgesics Phase 4
12 Neurotransmitter Agents Phase 4
13 Narcotics Phase 4
14 Gastrointestinal Agents Phase 4
15 Hormone Antagonists Phase 4
16 Analgesics, Opioid Phase 4
17 Cholinergic Agents Phase 4
18 Cholinesterase Inhibitors Phase 4
19
Norepinephrine Approved Phase 3 51-41-2 439260
20
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
21
Indomethacin Approved, Investigational Phase 3 53-86-1 3715
22
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
23
Emodepside Investigational, Vet_approved Phase 3 155030-63-0
24 Calcium, Dietary Phase 3
25 Dopamine Agents Phase 3
26 Psychotropic Drugs Phase 3
27 Duloxetine Hydrochloride Phase 3
28 Antidepressive Agents Phase 3
29 Serotonin and Noradrenaline Reuptake Inhibitors Phase 3
30 Anti-Inflammatory Agents Phase 3
31 Anti-Inflammatory Agents, Non-Steroidal Phase 3
32 Analgesics, Non-Narcotic Phase 3
33 Cyclooxygenase Inhibitors Phase 3
34 Antirheumatic Agents Phase 3
35 Pharmaceutical Solutions Phase 3
36 Tocolytic Agents Phase 3
37
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
38
Perphenazine Approved Phase 2 58-39-9 4748
39
Amitriptyline Approved Phase 2 50-48-6 2160
40 Tranquilizing Agents Phase 2
41 Antipsychotic Agents Phase 2
42 Amitriptyline, perphenazine drug combination Phase 2
43 Adrenergic Agents Phase 2
44 Antidepressive Agents, Tricyclic Phase 2
45
Pancrelipase Approved, Investigational Phase 1 53608-75-6
46 pancreatin Phase 1
47
Diclofenac Approved, Vet_approved 15307-86-5 3033
48
Bupivacaine Approved, Investigational 38396-39-3, 2180-92-9 2474
49
Ropivacaine Approved 84057-95-4 71273 175805
50 Central Nervous System Depressants

Interventional clinical trials:

(show all 25)
# Name Status NCT ID Phase Drugs
1 Application of Pinaverium Bromide in the Treatment of Patients With Post-cholecystectomy Sphincter of Oddi Dysfunction (SOD): A Randomized, Controlled and Multicenter Clinical Study Unknown status NCT02833103 Phase 4 Danshu Capsules;Pinaverium Bromide
2 A Randomised, Double Blind Cross-over Study of Serial MRCP Following Morphine-neostigmine and Secretin Provocation in Healthy Volunteers Completed NCT01134848 Phase 4 Morphine;Neostigmine;0.9% saline;Secretin;0.9% saline
3 A Prospective Randomised Trial of 0.025 Wire Guided Cannulation Versus Current Practice 0.035 Wire Guided Cannulation Completed NCT01408264 Phase 4
4 Pilot Study of the Efficacy and Tolerability of Duloxetine in Patients With Suspected Functional Pancreatic/Biliary Pain (Sphincter of Oddi Dysfunction). Completed NCT00471315 Phase 3 Duloxetine
5 Prevention of Post-Endoscopic Retrograde Cholangiopancreatography (ERCP) - Induced Pancreatitis Using Aggressive Lactated Ringer's Infusion and/or Rectal Indomethacin Completed NCT02641561 Phase 3 Indomethacin;Lactated Ringer's Solution;Normal Saline;Placebo
6 Randomized Controlled Trial of Laparoscopic Cholecystectomy vs. Non-operative Treatment for Gallbladder Dyskinesia Unknown status NCT02195115 Phase 2 amitriptyline
7 Prospective Evaluation of the Use of a Biodegradable Endoprothesis in the Prevention of Post-Endoscopic Retrograde CholoangioPancreatography Pancreatitis Not yet recruiting NCT03977779 Phase 2
8 The Use of Non-invasive MRI to Quantify the Effect of Secretin on Pancreatic Blood Flow and Perfusion in Healthy Volunteers Completed NCT01452217 Phase 1 Secretin
9 Laparoscopic Cholecystectomy Using Transvaginal Endoscopic Assistance Withdrawn NCT00815438 Phase 1
10 Intramuscular Diclofenac in the Prevention of Post-ERCP Pancreatitis Unknown status NCT01717599 Diclofenac;normal saline
11 A Phase III Randomized Multicenter Clinical Trial of Sphincterotomy for the Treatment of SOD III Patients Completed NCT00688662
12 Early Precut Versus Pancreatic Duct Stent in Preventing Post-ERCP Pancreatitis in High-risk Subjects Completed NCT02497872
13 Effect of Anatomy of Major Duodenal Papilla on the Difficulty of Cannulation During Endoscopic Retrograde Cholangiopancreatography (ERCP) Completed NCT03550768
14 Defining the Role of ERCP in the Evaluation and Treatment of Idiopathic Recurrent Acute Pancreatitis Completed NCT01583517
15 Primary Needle Knife Fistulotomy Versus Conventional Cannulation Method in Patients With High Risk of Post-endoscopic Retrograde Cholangiopancreatography Pancreatitis: A Multicenter Randomized Controlled Trial Completed NCT02916199
16 Single Incision Versus Laparoscopic Cholecystectomy Completed NCT00981604
17 A Prospective, Multicenter, Randomized, Double-blind Controlled Study to Determine Whether a Single Dose of Intraduodenal Indomethacin Can Decrease the Incidence and Severity of Post-ERCP Pancreatitis Completed NCT00727740 Indomethacin;Placebo suspension
18 Natural Orifice Translumenal Endoscopic Surgery (NOTES) Transvaginal Cholecystectomy Completed NCT00984100
19 A Prospective Pilot Study to Evaluate the Effect of Virtual Reality as a Treatment Option for Pain in Patients With Functional Pancreaticobiliary Disorder or Type 3 Sphincter of Oddi Dysfunction Recruiting NCT03999333
20 QST Study: Predicting Treatment Response in Chronic Pancreatitis Using Quantitative Sensory Testing Recruiting NCT03434392
21 COMPLICATIONS OF ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY- AN INDIAN PERSPECTIVE Active, not recruiting NCT04062617
22 Trans-incisional Rectus Sheath Block Versus Laparoscopic Guided Rectus Sheath Block for Pediatric Single Incision Laparoscopic Cholecystectomy: A Prospective, Randomized Study Active, not recruiting NCT02494336 Ropivacaine
23 Evaluation of Gastrointestinal Symptoms and Quality of Life in Patients With Sphincter of Oddi Dysfunction: Evaluation of the Differences Between Those Undergoing Endoscopic Therapy vs.Conservative Care Terminated NCT01410071
24 Study to Investigate the Role of Ultrasound for Diagnosis of Biliary Dyskinesia Terminated NCT00737295
25 Single-Incision Laparoscopic Cholecystectomy Versus Traditional Laparoscopic Cholecystectomy: A Randomized Prospective Trial Terminated NCT01195285

Search NIH Clinical Center for Biliary Dyskinesia

Cochrane evidence based reviews: biliary dyskinesia

Genetic Tests for Biliary Dyskinesia

Anatomical Context for Biliary Dyskinesia

MalaCards organs/tissues related to Biliary Dyskinesia:

40
Liver, Pancreas, Testes, Heart, Spinal Cord, Colon, Bone

Publications for Biliary Dyskinesia

Articles related to Biliary Dyskinesia:

(show top 50) (show all 972)
# Title Authors PMID Year
1
Biliary dyskinesia: a potentially unrecognized cause of abdominal pain in children. 54 61
15322841 2004
2
Laparoscopic cholecystectomy for biliary dyskinesia: correlation of preoperative cholecystokinin cholescintigraphy results with postoperative outcome. 54 61
15054652 2004
3
Biliary dyskinesia: role of the sphincter of Oddi, gallbladder and cholecystokinin. 54 61
9374365 1997
4
Abnormal gallbladder nuclear ejection fraction predicts success of cholecystectomy in patients with biliary dyskinesia. 54 61
8273847 1993
5
Kinevac (sincalide for injection)/Squibb Diagnostics. 54 61
1932168 1991
6
Self-reported Outcomes After Cholecystectomy for Pediatric Hyperkinetic Biliary Dyskinesia. 61
31562988 2020
7
Risk factors of post-ERCP pancreatitis in high-risk patients despite prevention with prophylactic pancreatic stents. 61
31852319 2020
8
Functional Pancreatic Sphincter Dysfunction in Children: Recommendations for Diagnosis and Management. 61
31567892 2019
9
Maintaining the blind in sham controlled interventional trials: lessons from the EPISOD study. 61
31673601 2019
10
Overall outcomes of laparoscopic-assisted ERCP after Roux-en-Y gastric bypass and sphincter of Oddi dysfunction subgroup analysis. 61
31579709 2019
11
Post-endoscopic retrograde cholangiopancreatography pancreatitis: A systematic review for prevention and treatment. 61
31413535 2019
12
Clinical features and management of painless biliary type sphincter of Oddi dysfunction. 61
31122105 2019
13
Sphincter of Oddi Dysfunction After Gastric Bypass: Surgical or Endoscopic Therapy? 61
30738357 2019
14
Effects of Paeoniflorin on the activity of muscle strips, intracellular calcium ion concentration and L‑type voltage‑sensitive calcium ion channels in the sphincter of Oddi of hypercholesterolemic rabbits. 61
31059080 2019
15
Variability in perioperative evaluation and resource utilization in pediatric patients with suspected biliary dyskinesia: A multi-institutional retrospective cohort study. 61
30885555 2019
16
Biliary Tract Disease in Girls and Young Women With Rett Syndrome. 61
30664568 2019
17
Surgical outcome in patients with biliary colic and atypical workup findings. 61
31000093 2019
18
Is hyperkinetic gallbladder an indication for cholecystectomy? 61
30209609 2019
19
Laparoscopic cholecystectomy for ultrasound normal gallbladders: Should we forego hepatobiliary iminodiacetic acid scans? 61
30924462 2019
20
An Update on Biliary Dyskinesia. 61
30846030 2019
21
Systematic review with meta-analysis: cholecystectomy for biliary dyskinesia-what can the gallbladder ejection fraction tell us? 61
30706496 2019
22
A systematic review of the aetiology and management of post cholecystectomy syndrome. 61
29730174 2019
23
Role of laparoscopic cholecystectomy in the management of chronic right upper quadrant pain due to biliary dyskinesia: a systematic review and meta-analysis. 61
31620653 2019
24
Biliary hyperkinesia, a new diagnosis or misunderstood pathophysiology of dyskinesia: A case report. 61
30716707 2019
25
Clinical course of biliary-type sphincter of Oddi dysfunction: endoscopic sphincterotomy and functional dyspepsia as affecting factors. 61
31448369 2019
26
Characterization of the urinary metabolic profile of cholangiocarcinoma in a United Kingdom population. 61
31118840 2019
27
Etiologies of Long-Term Postcholecystectomy Symptoms: A Systematic Review. 61
31110517 2019
28
Recurrent Acute Pancreatitis: Current Concepts in the Diagnosis and Management. 61
30232693 2018
29
Update on the Prevention of Post-ERCP Pancreatitis. 61
30334143 2018
30
Biliary endoscopic sphincterotomy: Techniques and complications. 61
30613665 2018
31
Risk Factors for Post-ERCP Pancreatitis in High-Risk Patients Receiving Post-procedure Rectal Indomethacin. 61
29980976 2018
32
Long-term results of cholecystectomy for biliary dyskinesia: outcomes and resource utilization. 61
30100038 2018
33
Acute Biliary Disease. 61
30243451 2018
34
Pediatric Biliary Dyskinesia: Evaluating Predictive Factors for Successful Treatment of Biliary Dyskinesia with Laparoscopic Cholecystectomy. 61
30268165 2018
35
Sphincter of Oddi dysfunction: sphincter of Oddi dysfunction or discordance? What is the state of the art in 2018? 61
29916850 2018
36
Adverse Events and Reinterventions Following Pancreatic Endoscopic Sphincterotomy. 61
29912853 2018
37
Post-ERCP biliary complications in patients with biliary type sphincter of Oddi dysfunction. 61
29967373 2018
38
Pathologic Findings of the Gallbladder in Patients Undergoing Surgery for Biliary Dyskinesia 61
29981584 2018
39
Rectal Indomethacin Prevents Moderate to Severe Post-ERCP Pancreatitis and Death and Should Be Used Before the Procedure: A Meta-Analysis of Aggregate Subgroup Data. 61
31294402 2018
40
Trends of Cholecystectomies for Presumed Biliary Dyskinesia in Children in the United States. 61
29036007 2018
41
Idiopathic Pancreatitis as a Rare Gastrointestinal Manifestation of Myotonic Muscular Dystrophy. 61
29805942 2018
42
Cost Effective Therapy for Sphincter of Oddi Dysfunction. 61
28711688 2018
43
Poor Reproducibility of Gallbladder Ejection Fraction by Biliary Scintigraphy for Diagnosis of Biliary Dyskinesia. 61
29157795 2018
44
Effects of laparoscopic cholecystectomy in normokinetic biliary dyskinesia. 61
28669533 2018
45
Sphincter of Oddi dysfunction: the never-ending story has come to a conclusion. 61
29241851 2018
46
The EPISOD study: long-term outcomes. 61
28455162 2018
47
Randomized sham-controlled trials in endoscopy: a systematic review and meta-analysis of adverse events. 61
28802556 2017
48
Biliary Complications in Recipients of Living-Donor Liver Transplant: A Single-Center Review of 120 Patients. 61
29025382 2017
49
Influence of discharge timing and diagnosis on outcomes of pediatric laparoscopic cholecystectomy. 61
29050888 2017
50
Diabetes and the Pancreatobiliary Diseases. 61
29079901 2017

Variations for Biliary Dyskinesia

Expression for Biliary Dyskinesia

Search GEO for disease gene expression data for Biliary Dyskinesia.

Pathways for Biliary Dyskinesia

Pathways related to Biliary Dyskinesia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.55 SST CFTR ATP4A
2 10.93 SCT PRSS1 CFTR CCK
3 9.8 SCT CCK

GO Terms for Biliary Dyskinesia

Cellular components related to Biliary Dyskinesia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 SST SPINK1 SCT REG3A PRSS58 PRSS1
2 extracellular space GO:0005615 9.28 SST SPINK1 SCT REG3A PRSS1 GPT

Biological processes related to Biliary Dyskinesia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sperm capacitation GO:0048240 9.37 SPINK1 CFTR
2 cellular sodium ion homeostasis GO:0006883 9.32 ATP4A ATP12A
3 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.26 ATP4A ATP12A
4 sodium ion export across plasma membrane GO:0036376 9.16 ATP4A ATP12A
5 cellular potassium ion homeostasis GO:0030007 8.96 ATP4A ATP12A
6 digestion GO:0007586 8.8 SST PRSS1 CCK

Molecular functions related to Biliary Dyskinesia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.54 PRSS58 PRSS1 CELA1
2 serine-type peptidase activity GO:0008236 9.5 PRSS58 PRSS1 CELA1
3 hormone activity GO:0005179 9.43 SST SCT CCK
4 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP4A ATP12A
5 potassium-transporting ATPase activity GO:0008556 8.96 ATP4A ATP12A
6 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A

Sources for Biliary Dyskinesia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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