MCID: BLR004
MIFTS: 34

Biliary Dyskinesia

Categories: Gastrointestinal diseases

Aliases & Classifications for Biliary Dyskinesia

MalaCards integrated aliases for Biliary Dyskinesia:

Name: Biliary Dyskinesia 12 56 45 15 17 74
Sphincter of Oddi Dysfunction 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4140
MeSH 45 D001657
SNOMED-CT 69 43469007
UMLS 74 C0005416

Summaries for Biliary Dyskinesia

Disease Ontology : 12 A gallbladder disease characterized by altered tonus of the sphincter of Oddi, disturbance in the coordination of contraction of the biliary ducts, and/or reduction in the speed of emptying of the biliary tree.

MalaCards based summary : Biliary Dyskinesia, also known as sphincter of oddi dysfunction, is related to acute pancreatitis and duodenogastric reflux. An important gene associated with Biliary Dyskinesia is CCK (Cholecystokinin), and among its related pathways/superpathways is Gastric acid production. The drugs Pinaverium and Morphine have been mentioned in the context of this disorder. Affiliated tissues include testes, pancreas and liver.

Wikipedia : 77 Biliary dyskinesia is a disorder of some component of biliary part of the digestive system in which bile... more...

Related Diseases for Biliary Dyskinesia

Diseases related to Biliary Dyskinesia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
# Related Disease Score Top Affiliating Genes
1 acute pancreatitis 30.5 CCK SCT
2 duodenogastric reflux 30.0 CCK SCT
3 pancreatitis 29.9 CCK SCT
4 choledocholithiasis 29.8 SOBP STK10
5 recurrent acute pancreatitis 10.4
6 bile duct cysts 10.3
7 degos 'en cocarde' erythrokeratoderma 10.3
8 pancreatic cholera 10.1 CCK SCT
9 cholecystitis 10.1
10 pancreatic steatorrhea 10.1 CCK SCT
11 steatorrhea 10.1 CCK SCT
12 paine syndrome 10.1
13 somatization disorder 10.1
14 fibromyalgia 10.1
15 fascioliasis 10.1
16 achalasia 10.1
17 irritable bowel syndrome 10.1
18 pain - chronic 10.1
19 swallowing disorders 10.1
20 duodenal gastrinoma 10.1 CCK SCT
21 postcholecystectomy syndrome 10.1 CCK SOBP
22 space motion sickness 10.1 CCK SCT
23 exocrine pancreatic insufficiency 10.1 CCK SCT
24 alcoholic pancreatitis 10.1 CCK SCT
25 maturity-onset diabetes of the young, type 7 10.1 CCK SCT
26 cholelithiasis 10.0
27 gastroparesis 10.0
28 acalculous cholecystitis 10.0
29 duodenal ulcer 10.0 CCK SCT
30 pancreas disease 10.0 CCK SCT
31 panic disorder 9.9 CCK TSPO
32 cholecystolithiasis 9.9 CCK STK10
33 gastrointestinal system disease 9.9 CCK SCT
34 breast cancer 9.9
35 hypertriglyceridemia, familial 9.9
36 dermatitis, atopic 9.9
37 urticaria 9.9
38 constipation 9.9
39 dermatitis 9.9
40 causalgia 9.9
41 neurotic disorder 9.9
42 cholangitis 9.9
43 carotenemia 9.9
44 alcohol dependence 9.7 CCK TSPO
45 common bile duct disease 9.6 CCK SOBP STK10

Graphical network of the top 20 diseases related to Biliary Dyskinesia:



Diseases related to Biliary Dyskinesia

Symptoms & Phenotypes for Biliary Dyskinesia

Drugs & Therapeutics for Biliary Dyskinesia

Drugs for Biliary Dyskinesia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pinaverium Approved Phase 4 59995-65-2
2
Morphine Approved, Investigational Phase 4 57-27-2 5288826
3
Secretin Approved Phase 4 108153-74-8
4
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
5
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
6 Calcium, Dietary Phase 4
7 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
8 Bromides Phase 4
9 Parasympatholytics Phase 4
10 Autonomic Agents Phase 4
11 Hormones Phase 4
12 calcium channel blockers Phase 4
13 Anticonvulsants Phase 4
14 Analgesics Phase 4,Phase 3,Phase 2,Not Applicable
15 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
16 Central Nervous System Depressants Phase 4,Phase 2,Not Applicable
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
18 Cholinesterase Inhibitors Phase 4
19 Hormone Antagonists Phase 4
20 Analgesics, Opioid Phase 4
21 Gastrointestinal Agents Phase 4
22 Narcotics Phase 4
23 Cholinergic Agents Phase 4
24
Dopamine Approved Phase 3 62-31-7, 51-61-6 681
25
Norepinephrine Approved Phase 3 51-41-2 439260
26 Neurotransmitter Uptake Inhibitors Phase 3,Phase 2
27 Antidepressive Agents Phase 3,Phase 2
28 Psychotropic Drugs Phase 3,Phase 2
29 Duloxetine Hydrochloride Phase 3
30 Dopamine Agents Phase 3
31 Serotonin and Noradrenaline Reuptake Inhibitors Phase 3
32
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
33
Amitriptyline Approved Phase 2 50-48-6 2160
34
Perphenazine Approved Phase 2 58-39-9 4748
35 Amitriptyline, perphenazine drug combination Phase 2
36 Antidepressive Agents, Tricyclic Phase 2
37 Antipsychotic Agents Phase 2
38 Adrenergic Agents Phase 2
39 Analgesics, Non-Narcotic Phase 2,Not Applicable
40 Tranquilizing Agents Phase 2
41
Diclofenac Approved, Vet_approved Not Applicable 15307-86-5 3033
42
Indomethacin Approved, Investigational 53-86-1 3715
43
Midazolam Approved, Illicit 59467-70-8 4192
44
Pancrelipase Approved, Investigational 53608-75-6
45
Bupivacaine Approved, Investigational Not Applicable 38396-39-3, 2180-92-9 2474
46
Ropivacaine Approved Not Applicable 84057-95-4 175805 71273
47 Cyclooxygenase Inhibitors Not Applicable
48 Anti-Inflammatory Agents Not Applicable
49 Antirheumatic Agents Not Applicable
50 Anti-Inflammatory Agents, Non-Steroidal Not Applicable

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Pinaverium Bromide in Post-cholecystectomy Sphincter of Oddi Dysfunction Unknown status NCT02833103 Phase 4 Danshu Capsules;Pinaverium Bromide
2 A Study of Serial Magnetic Resonance Cholangiopancreatography (MRCP) Following Morphine-neostigmine and Secretin Provocation in Healthy Volunteers Completed NCT01134848 Phase 4 Morphine;Neostigmine;0.9% saline;Secretin;0.9% saline
3 Duloxetine in Patients With Suspected Functional Pancreatic/Biliary Pain (Sphincter of Oddi Dysfunction) Completed NCT00471315 Phase 3 Duloxetine
4 Trial of Laparoscopic Cholecystectomy vs. Non-operative Treatment for Gallbladder Dyskinesia Unknown status NCT02195115 Phase 2 amitriptyline
5 Transvaginal Cholecystectomy Using Endoscopic Assistance Withdrawn NCT00815438 Phase 1
6 Intramuscular Diclofenac in the Prevention of Post-ERCP Pancreatitis Unknown status NCT01717599 Not Applicable Diclofenac;normal saline
7 Natural Orifice Translumenal Endoscopic Surgery (NOTES) Transvaginal Cholecystectomy Completed NCT00984100 Not Applicable
8 Single Incision Laparoscopic Surgery (SILS) Versus Laparoscopic Cholecystectomy Completed NCT00981604 Not Applicable
9 Primary Needle Knife Fistulotomy Versus Conventional Cannulation Method Completed NCT02916199 Not Applicable
10 Evaluating Predictors & Interventions in Sphincter of Oddi Dysfunction Completed NCT00688662 Not Applicable
11 Early Precut Versus Pancreatic Stent for Post-ERCP Pancreatitis Completed NCT02497872 Not Applicable
12 Risk Factors of Post-ERCP Pancreatitis in Patients Receiving Rectal Indomethacin Completed NCT02709421
13 ERCP in Idiopathic Recurrent Acute Pancreatitis Completed NCT01583517 Not Applicable
14 The Clinical Evaluation of Oddi Spincteroplasty With Blood Vessel Clamp After Iatrogenic Injury by ERCP Recruiting NCT03795584 Not Applicable
15 QST Study: Predicting Treatment Response in Chronic Pancreatitis Using Quantitative Sensory Testing Recruiting NCT03434392 Not Applicable
16 Effect of Anatomy of Major Duodenal Papilla on the Difficulty of Cannulation During Endoscopic Retrograde Cholangiopancreatography Recruiting NCT03550768
17 The Association Between Post-ERCP Acute Pancreatitis and Various Genetic Mutations Recruiting NCT02928718
18 Trans-incisional vs Laparoscopic Guided Rectus Sheath Block for Pediatric Single Incision Laparoscopic Cholecystectomy Active, not recruiting NCT02494336 Not Applicable Ropivacaine
19 Ultrasound for Diagnosis of Biliary Dyskinesia Terminated NCT00737295 Not Applicable
20 Single-Incision Laparoscopic Cholecystectomy Versus Traditional Laparoscopic Cholecystectomy Terminated NCT01195285 Not Applicable
21 Evaluation of Gastrointestinal Symptoms and Quality of Life in Patients With Sphincter of Oddi Dysfunction Terminated NCT01410071

Search NIH Clinical Center for Biliary Dyskinesia

Cochrane evidence based reviews: biliary dyskinesia

Genetic Tests for Biliary Dyskinesia

Anatomical Context for Biliary Dyskinesia

MalaCards organs/tissues related to Biliary Dyskinesia:

42
Testes, Pancreas, Liver, Breast, Spinal Cord

Publications for Biliary Dyskinesia

Articles related to Biliary Dyskinesia:

(show top 50) (show all 329)
# Title Authors Year
1
Systematic review with meta-analysis: cholecystectomy for biliary dyskinesia-what can the gallbladder ejection fraction tell us? ( 30706496 )
2019
2
An Update on Biliary Dyskinesia. ( 30846030 )
2019
3
Variability in perioperative evaluation and resource utilization in pediatric patients with suspected biliary dyskinesia: A multi-institutional retrospective cohort study. ( 30885555 )
2019
4
Sphincter of Oddi Dysfunction After Gastric Bypass: Surgical or Endoscopic Therapy? ( 30738357 )
2019
5
Effects of laparoscopic cholecystectomy in normokinetic biliary dyskinesia. ( 28669533 )
2018
6
Trends of Cholecystectomies for Presumed Biliary Dyskinesia in Children in the United States. ( 29036007 )
2018
7
Poor Reproducibility of Gallbladder Ejection Fraction by Biliary Scintigraphy for Diagnosis of Biliary Dyskinesia. ( 29157795 )
2018
8
Pathologic Findings of the Gallbladder in Patients Undergoing Surgery for Biliary Dyskinesia ( 29981584 )
2018
9
Long-term results of cholecystectomy for biliary dyskinesia: outcomes and resource utilization. ( 30100038 )
2018
10
Pediatric Biliary Dyskinesia: Evaluating Predictive Factors for Successful Treatment of Biliary Dyskinesia with Laparoscopic Cholecystectomy. ( 30268165 )
2018
11
Cost Effective Therapy for Sphincter of Oddi Dysfunction. ( 28711688 )
2018
12
Sphincter of Oddi dysfunction: the never-ending story has come to a conclusion. ( 29241851 )
2018
13
Sphincter of Oddi dysfunction: sphincter of Oddi dysfunction or discordance? What is the state of the art in 2018? ( 29916850 )
2018
14
Post-ERCP biliary complications in patients with biliary type sphincter of Oddi dysfunction. ( 29967373 )
2018
15
Biliary Dyskinesia in Children: A Systematic Review. ( 27472474 )
2017
16
Outcomes of Laparoscopic Cholecystectomy for Biliary Dyskinesia in Children. ( 28350202 )
2017
17
Decision-making patterns in managing children with suspected biliary dyskinesia. ( 28540197 )
2017
18
Gallbladder Dysfunction: Cholecystitis, Choledocholithiasis, Cholangitis, and Biliary Dyskinesia. ( 29132521 )
2017
19
Risk factors of post- endoscopic retrograde cholangiopancreatography pancreatitis in biliary type sphincter of Oddi dysfunction in Japanese patients. ( 28898571 )
2017
20
Outcomes of Endoscopic Retrograde Cholangiopancreatography (ERCP) and Sphincterotomy for Suspected Sphincter of Oddi Dysfunction (SOD) Post Roux-En-Y Gastric Bypass. ( 28488091 )
2017
21
Pilot Randomized Controlled Trial of Laparoscopic Cholecystectomy vs Active Nonoperative Therapy for the Treatment of Biliary Dyskinesia. ( 27049778 )
2016
22
The Utility of Nuclear Medicine Scans for Diagnosing Pediatric Biliary Dyskinesia Remains Unclear. ( 27149253 )
2016
23
Duloxetine for the Treatment of Patients with Suspected Sphincter of Oddi Dysfunction: A Pilot Study. ( 27165434 )
2016
24
Management of Sphincter of Oddi Dysfunction: Teaching an Old SOD New Tricks? ( 27435328 )
2016
25
Opium-related sphincter of Oddi dysfunction causing double duct sign. ( 27503161 )
2016
26
Translational and clinical perspectives on sphincter of Oddi dysfunction. ( 27555792 )
2016
27
Wide disparities in attitudes and practices regarding Type II sphincter of Oddi dysfunction: a survey of expert U.S. endoscopists. ( 27652298 )
2016
28
Post-cholecystectomy syndrome and sphincter of Oddi dysfunction: past, present and future. ( 27762149 )
2016
29
Sphincter of Oddi Dysfunction: A Perplexing Presentation. ( 28100991 )
2016
30
Biliary dyskinesia: a surgical disease rarely found outside the United States. ( 25771131 )
2015
31
Prediction of symptom improvement in children with biliary dyskinesia. ( 25891671 )
2015
32
In response to: Preston JF, Diggs BS, Dolan JP, Gilbert EW, Schein M, Hunter JG. Biliary dyskinesia: a surgical disease rarely found outside the United States. Am J Surg. 2015;209:799-803. ( 26116320 )
2015
33
HIDA Scan with Ejection Fraction Is over Utilized in the Management of Biliary Dyskinesia. ( 26140885 )
2015
34
Sphincter of Oddi Dysfunction and the Formation of Adult Choledochal Cyst Following Cholecystectomy: A Retrospective Cohort Study. ( 26632721 )
2015
35
Endoscopic sphincterotomy for sphincter of oddi dysfunction: inefficacious therapy for a fictitious disease. ( 25532810 )
2015
36
Spinal cord stimulation for intractable visceral pain due to sphincter of oddi dysfunction. ( 25589948 )
2015
37
A Trial of Rectal Indomethacin to Prevent Post-ERCP Pancreatitis in Patients with Suspected Type 3 Sphincter of Oddi Dysfunction. ( 25868629 )
2015
38
Determinants of long-term complications of endoscopic sphincterotomy are infections and high risk factors of bile duct and not sphincter of Oddi dysfunction. ( 25874514 )
2015
39
Sphincter of Oddi dysfunction Type III: New studies suggest new approaches are needed. ( 26019439 )
2015
40
Sphincter of Oddi Dysfunction: Updates from the Recent Literature. ( 26143628 )
2015
41
Incidence and predictors of post-ERCP pancreatitis in patients with suspected sphincter of Oddi dysfunction undergoing biliary or dual sphincterotomy: results from the EPISOD prospective multicenter randomized sham-controlled study. ( 26165739 )
2015
42
Sphincter of Oddi Dysfunction. ( 26431602 )
2015
43
Erratum to: A Trial of Rectal Indomethacin to Prevent Post-ERCP Pancreatitis in Patients with Suspected Type 3 Sphincter of Oddi Dysfunction. ( 26438337 )
2015
44
Acalculous cholecystitis or biliary dyskinesia for Epstein-Barr virus gallbladder involvement? ( 24874936 )
2014
45
Osteopathic manipulative treatment in the management of biliary dyskinesia. ( 24481806 )
2014
46
Long-term efficacy of laparoscopic cholecystectomy for the treatment of biliary dyskinesia. ( 24581761 )
2014
47
Biliary dyskinesia and symptomatic gallstone disease in children: two sides of the same coin? ( 24715545 )
2014
48
Biliary dyskinesia in pediatrics. ( 24716563 )
2014
49
Cholecystectomy for biliary dyskinesia: how did we get there? ( 25193389 )
2014
50
Cholecystectomy for biliary dyskinesia in gastroparesis: mimic or misfortune? ( 25502153 )
2014

Variations for Biliary Dyskinesia

Expression for Biliary Dyskinesia

Search GEO for disease gene expression data for Biliary Dyskinesia.

Pathways for Biliary Dyskinesia

Pathways related to Biliary Dyskinesia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.47 CCK SCT

GO Terms for Biliary Dyskinesia

Biological processes related to Biliary Dyskinesia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of mitochondrial depolarization GO:0051901 8.62 CCK TSPO

Molecular functions related to Biliary Dyskinesia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.62 CCK SCT

Sources for Biliary Dyskinesia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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