MCID: BLR004
MIFTS: 33

Biliary Dyskinesia

Categories: Gastrointestinal diseases

Aliases & Classifications for Biliary Dyskinesia

MalaCards integrated aliases for Biliary Dyskinesia:

Name: Biliary Dyskinesia 12 55 44 15 17 72
Sphincter of Oddi Dysfunction 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4140
MeSH 44 D001657
SNOMED-CT 68 43469007
UMLS 72 C0005416

Summaries for Biliary Dyskinesia

Disease Ontology : 12 A gallbladder disease characterized by altered tonus of the sphincter of Oddi, disturbance in the coordination of contraction of the biliary ducts, and/or reduction in the speed of emptying of the biliary tree.

MalaCards based summary : Biliary Dyskinesia, also known as sphincter of oddi dysfunction, is related to pancreatitis and acute pancreatitis. An important gene associated with Biliary Dyskinesia is CCK (Cholecystokinin), and among its related pathways/superpathways is Gastric acid production. The drugs Pinaverium and Neostigmine have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and pancreas.

Wikipedia : 75 Biliary dyskinesia is a disorder of some component of biliary part of the digestive system in which bile... more...

Related Diseases for Biliary Dyskinesia

Diseases related to Biliary Dyskinesia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 87)
# Related Disease Score Top Affiliating Genes
1 pancreatitis 31.3 SCT CCK
2 acute pancreatitis 30.9 SCT CCK
3 duodenogastric reflux 30.4 SCT CCK
4 cholecystolithiasis 30.2 STK10 CCK
5 duodenal ulcer 30.2 SCT CCK
6 postcholecystectomy syndrome 30.1 SOBP CCK
7 choledocholithiasis 30.1 STK10 SOBP
8 cholecystitis 10.6
9 recurrent acute pancreatitis 10.6
10 cholelithiasis 10.5
11 gallbladder disease 1 10.5
12 bile duct cysts 10.4
13 acalculous cholecystitis 10.3
14 gallbladder disease 10.3
15 optic papillitis 10.3
16 gastritis 10.2
17 pancreatic cholera 10.2 SCT CCK
18 duodenal gastrinoma 10.2 SCT CCK
19 constipation 10.2
20 dyspepsia 10.2
21 pancreatic steatorrhea 10.2 SCT CCK
22 steatorrhea 10.2 SCT CCK
23 space motion sickness 10.2 SCT CCK
24 alcoholic pancreatitis 10.1 SCT CCK
25 biliary tract disease 10.1
26 hypercholesterolemia, familial, 1 10.1
27 paine syndrome 10.1
28 muscle hypertrophy 10.1
29 leptin deficiency or dysfunction 10.1
30 opioid abuse 10.1
31 allergic hypersensitivity disease 10.1
32 somatization disorder 10.1
33 fibromyalgia 10.1
34 adenoma 10.1
35 fascioliasis 10.1
36 47,xyy 10.1
37 chronic pain 10.1
38 dysphagia 10.1
39 swallowing disorders 10.1
40 exocrine pancreatic insufficiency 10.1 SCT CCK
41 maturity-onset diabetes of the young, type 7 10.1 SCT CCK
42 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.0
43 strawberry gallbladder 10.0
44 gastroparesis 10.0
45 esophagitis 10.0
46 peptic ulcer disease 10.0
47 pancreas disease 10.0 SCT CCK
48 gastroesophageal reflux 9.9
49 breast cancer 9.9
50 hernia, hiatus 9.9

Graphical network of the top 20 diseases related to Biliary Dyskinesia:



Diseases related to Biliary Dyskinesia

Symptoms & Phenotypes for Biliary Dyskinesia

Drugs & Therapeutics for Biliary Dyskinesia

Drugs for Biliary Dyskinesia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 55)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pinaverium Approved Phase 4 59995-65-2
2
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
3
Morphine Approved, Investigational Phase 4 57-27-2 5288826
4
Secretin Approved Phase 4 108153-74-8
5 Parasympatholytics Phase 4
6 Anticonvulsants Phase 4
7 Bromides Phase 4
8 calcium channel blockers Phase 4
9 Hormones Phase 4
10 Autonomic Agents Phase 4
11 Analgesics Phase 4
12 Neurotransmitter Agents Phase 4
13 Hormone Antagonists Phase 4
14 Cholinesterase Inhibitors Phase 4
15 Narcotics Phase 4
16 Gastrointestinal Agents Phase 4
17 Cholinergic Agents Phase 4
18 Analgesics, Opioid Phase 4
19 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
20
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
21
Norepinephrine Approved Phase 3 51-41-2 439260
22
Indomethacin Approved, Investigational Phase 3 53-86-1 3715
23
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
24
Emodepside Investigational, Vet_approved Phase 3 155030-63-0
25 Calcium, Dietary Phase 3
26 Psychotropic Drugs Phase 3
27 Neurotransmitter Uptake Inhibitors Phase 3
28 Serotonin and Noradrenaline Reuptake Inhibitors Phase 3
29 Dopamine Agents Phase 3
30 Duloxetine Hydrochloride Phase 3
31 Antidepressive Agents Phase 3
32 Analgesics, Non-Narcotic Phase 3
33 Cyclooxygenase Inhibitors Phase 3
34 Anti-Inflammatory Agents, Non-Steroidal Phase 3
35 Anti-Inflammatory Agents Phase 3
36 Antirheumatic Agents Phase 3
37 Pharmaceutical Solutions Phase 3
38 Tocolytic Agents Phase 3
39
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
40
Amitriptyline Approved Phase 2 50-48-6 2160
41
Perphenazine Approved Phase 2 58-39-9 4748
42 Adrenergic Agents Phase 2
43 Tranquilizing Agents Phase 2
44 Amitriptyline, perphenazine drug combination Phase 2
45 Antipsychotic Agents Phase 2
46 Antidepressive Agents, Tricyclic Phase 2
47
Pancrelipase Approved, Investigational Phase 1 53608-75-6
48 pancreatin Phase 1
49
Diclofenac Approved, Vet_approved 15307-86-5 3033
50
Ropivacaine Approved 84057-95-4 71273 175805

Interventional clinical trials:

(show all 25)
# Name Status NCT ID Phase Drugs
1 Application of Pinaverium Bromide in the Treatment of Patients With Post-cholecystectomy Sphincter of Oddi Dysfunction (SOD): A Randomized, Controlled and Multicenter Clinical Study Unknown status NCT02833103 Phase 4 Danshu Capsules;Pinaverium Bromide
2 A Randomised, Double Blind Cross-over Study of Serial MRCP Following Morphine-neostigmine and Secretin Provocation in Healthy Volunteers Completed NCT01134848 Phase 4 Morphine;Neostigmine;0.9% saline;Secretin;0.9% saline
3 A Prospective Randomised Trial of 0.025 Wire Guided Cannulation Versus Current Practice 0.035 Wire Guided Cannulation Completed NCT01408264 Phase 4
4 Pilot Study of the Efficacy and Tolerability of Duloxetine in Patients With Suspected Functional Pancreatic/Biliary Pain (Sphincter of Oddi Dysfunction). Completed NCT00471315 Phase 3 Duloxetine
5 Prevention of Post-Endoscopic Retrograde Cholangiopancreatography (ERCP) - Induced Pancreatitis Using Aggressive Lactated Ringer's Infusion and/or Rectal Indomethacin Completed NCT02641561 Phase 3 Indomethacin;Lactated Ringer's Solution;Normal Saline;Placebo
6 Randomized Controlled Trial of Laparoscopic Cholecystectomy vs. Non-operative Treatment for Gallbladder Dyskinesia Unknown status NCT02195115 Phase 2 amitriptyline
7 Prospective Evaluation of the Use of a Biodegradable Endoprothesis in the Prevention of Post-Endoscopic Retrograde CholoangioPancreatography Pancreatitis Not yet recruiting NCT03977779 Phase 2
8 The Use of Non-invasive MRI to Quantify the Effect of Secretin on Pancreatic Blood Flow and Perfusion in Healthy Volunteers Completed NCT01452217 Phase 1 Secretin
9 Laparoscopic Cholecystectomy Using Transvaginal Endoscopic Assistance Withdrawn NCT00815438 Phase 1
10 Intramuscular Diclofenac in the Prevention of Post-ERCP Pancreatitis Unknown status NCT01717599 Diclofenac;normal saline
11 A Phase III Randomized Multicenter Clinical Trial of Sphincterotomy for the Treatment of SOD III Patients Completed NCT00688662
12 Early Precut Versus Pancreatic Duct Stent in Preventing Post-ERCP Pancreatitis in High-risk Subjects Completed NCT02497872
13 Effect of Anatomy of Major Duodenal Papilla on the Difficulty of Cannulation During Endoscopic Retrograde Cholangiopancreatography (ERCP) Completed NCT03550768
14 Defining the Role of ERCP in the Evaluation and Treatment of Idiopathic Recurrent Acute Pancreatitis Completed NCT01583517
15 Primary Needle Knife Fistulotomy Versus Conventional Cannulation Method in Patients With High Risk of Post-endoscopic Retrograde Cholangiopancreatography Pancreatitis: A Multicenter Randomized Controlled Trial Completed NCT02916199
16 Single Incision Versus Laparoscopic Cholecystectomy Completed NCT00981604
17 A Prospective, Multicenter, Randomized, Double-blind Controlled Study to Determine Whether a Single Dose of Intraduodenal Indomethacin Can Decrease the Incidence and Severity of Post-ERCP Pancreatitis Completed NCT00727740 Indomethacin;Placebo suspension
18 Natural Orifice Translumenal Endoscopic Surgery (NOTES) Transvaginal Cholecystectomy Completed NCT00984100
19 A Prospective Pilot Study to Evaluate the Effect of Virtual Reality as a Treatment Option for Pain in Patients With Functional Pancreaticobiliary Disorder or Type 3 Sphincter of Oddi Dysfunction Recruiting NCT03999333
20 QST Study: Predicting Treatment Response in Chronic Pancreatitis Using Quantitative Sensory Testing Recruiting NCT03434392
21 COMPLICATIONS OF ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY- AN INDIAN PERSPECTIVE Active, not recruiting NCT04062617
22 Trans-incisional Rectus Sheath Block Versus Laparoscopic Guided Rectus Sheath Block for Pediatric Single Incision Laparoscopic Cholecystectomy: A Prospective, Randomized Study Active, not recruiting NCT02494336 Ropivacaine
23 Evaluation of Gastrointestinal Symptoms and Quality of Life in Patients With Sphincter of Oddi Dysfunction: Evaluation of the Differences Between Those Undergoing Endoscopic Therapy vs.Conservative Care Terminated NCT01410071
24 Study to Investigate the Role of Ultrasound for Diagnosis of Biliary Dyskinesia Terminated NCT00737295
25 Single-Incision Laparoscopic Cholecystectomy Versus Traditional Laparoscopic Cholecystectomy: A Randomized Prospective Trial Terminated NCT01195285

Search NIH Clinical Center for Biliary Dyskinesia

Cochrane evidence based reviews: biliary dyskinesia

Genetic Tests for Biliary Dyskinesia

Anatomical Context for Biliary Dyskinesia

MalaCards organs/tissues related to Biliary Dyskinesia:

41
Liver, Testes, Pancreas, Colon, Spinal Cord, Heart, Bone

Publications for Biliary Dyskinesia

Articles related to Biliary Dyskinesia:

(show top 50) (show all 967)
# Title Authors PMID Year
1
Biliary dyskinesia: a potentially unrecognized cause of abdominal pain in children. 9 38
15322841 2004
2
Laparoscopic cholecystectomy for biliary dyskinesia: correlation of preoperative cholecystokinin cholescintigraphy results with postoperative outcome. 9 38
15054652 2004
3
Biliary dyskinesia: role of the sphincter of Oddi, gallbladder and cholecystokinin. 9 38
9374365 1997
4
Abnormal gallbladder nuclear ejection fraction predicts success of cholecystectomy in patients with biliary dyskinesia. 9 38
8273847 1993
5
Kinevac (sincalide for injection)/Squibb Diagnostics. 9 38
1932168 1991
6
Post-endoscopic retrograde cholangiopancreatography pancreatitis: A systematic review for prevention and treatment. 38
31413535 2019
7
Clinical features and management of painless biliary type sphincter of Oddi dysfunction. 38
31122105 2019
8
Sphincter of Oddi Dysfunction After Gastric Bypass: Surgical or Endoscopic Therapy? 38
30738357 2019
9
Effects of Paeoniflorin on the activity of muscle strips, intracellular calcium ion concentration and L‑type voltage‑sensitive calcium ion channels in the sphincter of Oddi of hypercholesterolemic rabbits. 38
31059080 2019
10
Biliary Tract Disease in Girls and Young Women With Rett Syndrome. 38
30664568 2019
11
Variability in perioperative evaluation and resource utilization in pediatric patients with suspected biliary dyskinesia: A multi-institutional retrospective cohort study. 38
30885555 2019
12
Surgical outcome in patients with biliary colic and atypical workup findings. 38
31000093 2019
13
Is hyperkinetic gallbladder an indication for cholecystectomy? 38
30209609 2019
14
An Update on Biliary Dyskinesia. 38
30846030 2019
15
Laparoscopic cholecystectomy for ultrasound normal gallbladders: Should we forego hepatobiliary iminodiacetic acid scans? 38
30924462 2019
16
Systematic review with meta-analysis: cholecystectomy for biliary dyskinesia-what can the gallbladder ejection fraction tell us? 38
30706496 2019
17
A systematic review of the aetiology and management of post cholecystectomy syndrome. 38
29730174 2019
18
Biliary hyperkinesia, a new diagnosis or misunderstood pathophysiology of dyskinesia: A case report. 38
30716707 2019
19
Characterization of the urinary metabolic profile of cholangiocarcinoma in a United Kingdom population. 38
31118840 2019
20
Etiologies of Long-Term Postcholecystectomy Symptoms: A Systematic Review. 38
31110517 2019
21
Recurrent Acute Pancreatitis: Current Concepts in the Diagnosis and Management. 38
30232693 2018
22
Update on the Prevention of Post-ERCP Pancreatitis. 38
30334143 2018
23
Biliary endoscopic sphincterotomy: Techniques and complications. 38
30613665 2018
24
Risk Factors for Post-ERCP Pancreatitis in High-Risk Patients Receiving Post-procedure Rectal Indomethacin. 38
29980976 2018
25
Long-term results of cholecystectomy for biliary dyskinesia: outcomes and resource utilization. 38
30100038 2018
26
Acute Biliary Disease. 38
30243451 2018
27
Pediatric Biliary Dyskinesia: Evaluating Predictive Factors for Successful Treatment of Biliary Dyskinesia with Laparoscopic Cholecystectomy. 38
30268165 2018
28
Sphincter of Oddi dysfunction: sphincter of Oddi dysfunction or discordance? What is the state of the art in 2018? 38
29916850 2018
29
Adverse Events and Reinterventions Following Pancreatic Endoscopic Sphincterotomy. 38
29912853 2018
30
Post-ERCP biliary complications in patients with biliary type sphincter of Oddi dysfunction. 38
29967373 2018
31
Pathologic Findings of the Gallbladder in Patients Undergoing Surgery for Biliary Dyskinesia. 38
30454529 2018
32
Pathologic Findings of the Gallbladder in Patients Undergoing Surgery for Biliary Dyskinesia 38
29981584 2018
33
Pathologic Findings of the Gallbladder in Patients Undergoing Surgery for Biliary Dyskinesia. 38
30219129 2018
34
Rectal Indomethacin Prevents Moderate to Severe Post-ERCP Pancreatitis and Death and Should Be Used Before the Procedure: A Meta-Analysis of Aggregate Subgroup Data. 38
31294402 2018
35
Trends of Cholecystectomies for Presumed Biliary Dyskinesia in Children in the United States. 38
29036007 2018
36
Idiopathic Pancreatitis as a Rare Gastrointestinal Manifestation of Myotonic Muscular Dystrophy. 38
29805942 2018
37
Cost Effective Therapy for Sphincter of Oddi Dysfunction. 38
28711688 2018
38
Poor Reproducibility of Gallbladder Ejection Fraction by Biliary Scintigraphy for Diagnosis of Biliary Dyskinesia. 38
29157795 2018
39
Effects of laparoscopic cholecystectomy in normokinetic biliary dyskinesia. 38
28669533 2018
40
Sphincter of Oddi dysfunction: the never-ending story has come to a conclusion. 38
29241851 2018
41
The EPISOD study: long-term outcomes. 38
28455162 2018
42
Randomized sham-controlled trials in endoscopy: a systematic review and meta-analysis of adverse events. 38
28802556 2017
43
Biliary Complications in Recipients of Living-Donor Liver Transplant: A Single-Center Review of 120 Patients. 38
29025382 2017
44
Influence of discharge timing and diagnosis on outcomes of pediatric laparoscopic cholecystectomy. 38
29050888 2017
45
Diabetes and the Pancreatobiliary Diseases. 38
29079901 2017
46
Gallbladder Dysfunction: Cholecystitis, Choledocholithiasis, Cholangitis, and Biliary Dyskinesia. 38
29132521 2017
47
Endoscopic retrograde cholangiopancreatography with ampullary biopsy vs ERCP alone: a matched-pairs controlled evaluation of outcomes and complications. 38
28065885 2017
48
Eluxadoline in irritable bowel syndrome with diarrhea: rationale, evidence and place in therapy. 38
29090081 2017
49
Variation in prophylactic antibiotic use for laparoscopic cholecystectomy: need for better stewardship in pediatric surgery. 38
29106917 2017
50
Risk factors of pancreatitis after endoscopic sphincterotomy. Review of literature and practical remarks based on approximately 10,000 ERCPs. 38
29154236 2017

Variations for Biliary Dyskinesia

Expression for Biliary Dyskinesia

Search GEO for disease gene expression data for Biliary Dyskinesia.

Pathways for Biliary Dyskinesia

Pathways related to Biliary Dyskinesia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.47 SCT CCK

GO Terms for Biliary Dyskinesia

Biological processes related to Biliary Dyskinesia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of mitochondrial depolarization GO:0051901 8.62 TSPO CCK

Molecular functions related to Biliary Dyskinesia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.62 SCT CCK

Sources for Biliary Dyskinesia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
Content
Loading form....