MCID: BLR005
MIFTS: 37

Biliary Papillomatosis

Categories: Cancer diseases, Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Biliary Papillomatosis

MalaCards integrated aliases for Biliary Papillomatosis:

Name: Biliary Papillomatosis 12 15 74
Bile Duct Papillomatosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5468
NCIt 51 C65198

Summaries for Biliary Papillomatosis

Disease Ontology : 12 A biliary tract benign neoplasm characterized by multiple papillary tumors in the intrahepatic and/or extrahepatic biliary tree.

MalaCards based summary : Biliary Papillomatosis, also known as bile duct papillomatosis, is related to bile duct cysts and papilloma. An important gene associated with Biliary Papillomatosis is MUC17 (Mucin 17, Cell Surface Associated), and among its related pathways/superpathways are Metabolism of proteins and Gastric cancer. Affiliated tissues include liver, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Biliary Papillomatosis

Diseases related to Biliary Papillomatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 259)
# Related Disease Score Top Affiliating Genes
1 bile duct cysts 30.9 HRAS KRAS
2 papilloma 30.4 KRT20 KRT7 TP53
3 adenocarcinoma 30.0 HRAS KRAS MUC1 TP53
4 intrahepatic cholangiocarcinoma 28.2 CDX2 KRAS KRT19 KRT20 KRT7 MUC1
5 cholangiocarcinoma 27.9 CDX2 CEACAM5 KRAS KRT19 KRT20 KRT7
6 intrahepatic biliary papillomatosis 12.4
7 extrahepatic biliary papillomatosis 12.4
8 cap polyposis 10.5 MUC2 MUC5AC
9 tn polyagglutination syndrome 10.5 MUC1 MUC2
10 small intestine adenocarcinoma 10.5 MUC2 MUC6
11 microcystic adenoma 10.5 MUC1 MUC6
12 endosalpingiosis 10.4 KRT7 MUC1
13 endocervical carcinoma 10.4 KRT7 MUC6
14 parachordoma 10.4 KRT7 MUC1
15 cervical polyp 10.4 CDX2 MUC6
16 chronic cholangitis 10.4 CDX2 MUC2
17 secretory meningioma 10.4 KRT7 MUC1
18 middle ear adenoma 10.4 KRT7 MUC1
19 monophasic synovial sarcoma 10.4 KRT7 MUC1
20 hepatoid adenocarcinoma 10.4 CDX2 MUC1
21 nasal cavity cancer 10.4 CDX2 KRT7
22 ovary neuroendocrine neoplasm 10.4 CDX2 KRT7
23 epithelial predominant wilms' tumor 10.4 CDX2 KRT7
24 chordoid glioma 10.4 MUC1 TP53
25 sarcomatoid renal cell carcinoma 10.4 MUC1 TP53
26 vulvar disease 10.4 KRT7 TP53
27 female reproductive endometrioid cancer 10.4 KRT7 TP53
28 vulvar intraepithelial neoplasia 10.4 KRT7 TP53
29 syringocystadenoma papilliferum 10.4 KRAS MUC1
30 hidradenoma 10.3 KRT7 MUC1
31 mature teratoma 10.3 KRAS TP53
32 rare adenocarcinoma of the breast 10.3 KRAS TP53
33 hyperplastic polyposis syndrome 10.3 KRAS TP53
34 mutyh-associated polyposis 10.3 KRAS TP53
35 large intestine adenocarcinoma 10.3 KRT20 KRT7
36 malignant leydig cell tumor 10.3 KRT19 KRT7
37 chondroid lipoma 10.3 KRT19 KRT7
38 bladder lymphoma 10.3 KRT20 KRT7
39 seminal vesicle adenocarcinoma 10.3 KRT20 KRT7
40 corneal abscess 10.3 KRT19 KRT7
41 transverse colon cancer 10.3 KRT20 KRT7
42 papillary transitional carcinoma 10.3 KRT20 KRT7
43 linitis plastica 10.3 KRT20 KRT7
44 cystic basal cell carcinoma 10.3 KRT20 KRT7
45 medulloepithelioma 10.3 KRT20 KRT7
46 spitz nevus 10.3 HRAS TP53
47 renal pelvis adenocarcinoma 10.3 KRT19 KRT7
48 intrahepatic bile duct adenoma 10.3 KRT19 KRT7
49 adenoid squamous cell carcinoma 10.3 KRT20 KRT7
50 schimmelpenning-feuerstein-mims syndrome 10.3 HRAS KRAS

Graphical network of the top 20 diseases related to Biliary Papillomatosis:



Diseases related to Biliary Papillomatosis

Symptoms & Phenotypes for Biliary Papillomatosis

GenomeRNAi Phenotypes related to Biliary Papillomatosis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.47 HRAS KRAS MUC1
2 Decreased viability GR00106-A-0 9.47 KRAS
3 Decreased viability GR00221-A-1 9.47 HRAS KRAS
4 Decreased viability GR00221-A-2 9.47 HRAS KRAS
5 Decreased viability GR00221-A-3 9.47 HRAS
6 Decreased viability GR00301-A 9.47 KRAS
7 Decreased viability GR00381-A-1 9.47 KRAS
8 Decreased viability GR00402-S-2 9.47 HRAS KRAS MUC1

MGI Mouse Phenotypes related to Biliary Papillomatosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.5 CDX2 HRAS KRAS KRT19 MUC2 MUC5AC
2 neoplasm MP:0002006 9.1 CDX2 HRAS KRAS KRT19 MUC2 TP53

Drugs & Therapeutics for Biliary Papillomatosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Contrast Enhanced Ultrasound and Molecular Analysis in the Diagnosis of Pancreatic Cyst Recruiting NCT03740360
2 Whole-Exome Sequencing (WES) of Intraductal Neoplasms of the Bile Duct (IPNB) Not yet recruiting NCT03838913

Search NIH Clinical Center for Biliary Papillomatosis

Genetic Tests for Biliary Papillomatosis

Anatomical Context for Biliary Papillomatosis

MalaCards organs/tissues related to Biliary Papillomatosis:

42
Liver

Publications for Biliary Papillomatosis

Articles related to Biliary Papillomatosis:

(show top 50) (show all 79)
# Title Authors Year
1
Electrocoagulation of biliary papillomatosis during choledochoscopy. ( 30658359 )
2019
2
Surgical treatment of malignant biliary papillomatosis invading adjacent organs: A case report. ( 30705903 )
2019
3
Successful Orthotopic Liver Transplant for Diffuse Biliary Papillomatosis With Malignant Transformation: A Case Report With Long-Term Follow-Up. ( 29534660 )
2018
4
Caroli's disease associated with biliary papillomatosis and cholangiolithiasis. ( 29969806 )
2018
5
Tumor recurrence after liver transplantation for diffuse biliary papillomatosis in the absence of invasive carcinoma: a case report. ( 29938516 )
2018
6
Biliary papillomatosis. ( 30431667 )
2018
7
Robotic left hepatectomy and Roux-en-Y right hepatico-jejunostomy for biliary papillomatosis. ( 26845467 )
2016
8
Biliary papillomatosis with malignant transformation: A case report and review of the literature. ( 26722332 )
2015
9
Volume-reserving Surgery after Photodynamic Therapy for Biliary Papillomatosis: A Case Report. ( 26194131 )
2015
10
Recurrent cholangitis in a 65-year-old man. Biliary papillomatosis. ( 25533647 )
2015
11
Intrahepatic biliary papillomatosis associated with malignant transformation: report of two cases and review of the literature. ( 26885145 )
2015
12
Biliary papillomatosis: diagnosis with direct peroral cholangioscopy. ( 24929479 )
2014
13
Successful surgical treatment of extrahepatic biliary papillomatosis diagnosed with endoscopic retrograde cholangiopancreatography: a case report. ( 24885726 )
2014
14
Rare event of biliary papillomatosis arising in a choledochal cyst. ( 24990847 )
2014
15
Biliary papillomatosis. ( 24714176 )
2014
16
Biliary papillomatosis: correlation of radiologic findings with percutaneous transhepatic cholangioscopy. ( 24369325 )
2013
17
Biliary papillomatosis in the common bile duct. ( 23832505 )
2013
18
Extrahepatic biliary papillomatosis in a child. ( 24381830 )
2013
19
Biliary papillomatosis and new ultrasound imaging modalities. ( 22298103 )
2012
20
Multicentric biliary papillomatosis with synchronous gallbladder malignancy. ( 22803310 )
2012
21
Biliary papillomatosis in three Caucasian patients in a Western centre. ( 22154963 )
2012
22
Benign biliary papillomatosis in a patient with a choledochal cyst presenting as haemobilia: a case report. ( 22524914 )
2012
23
Biliary papillomatosis. Case report. ( 21988050 )
2011
24
Biliary papillomatosis diagnosed with mother-daughter narrow-band imaging (NBI) cholangioscopy. ( 21425023 )
2011
25
Biliary papillomatosis. ( 20879032 )
2010
26
Surgical strategy of biliary papillomatosis in Western countries. ( 19649560 )
2010
27
Multidisciplinary treatment of aggressive and rapidly progressing biliary papillomatosis. ( 20411427 )
2010
28
Mucin-producing intrahepatic biliary papillomatosis. ( 20740348 )
2010
29
Biliary papillomatosis with adenocarcinoma arising in choledochal cyst. ( 20426283 )
2009
30
Novel application of intraductal argon plasma coagulation in biliary papillomatosis (with video). ( 18656860 )
2009
31
Left hemihepatectomy and caudate lobectomy and complete extrahepatic bile duct resection using transduodenal approach for hilar cholangiocarcinoma arsing from biliary papillomatosis. ( 18521837 )
2008
32
Best cases from the AFIP: biliary papillomatosis. ( 19001658 )
2008
33
Biliary papillomatosis: analysis of 18 cases. ( 19187604 )
2008
34
Successful photodynamic therapy for biliary papillomatosis: a case report. ( 18636672 )
2008
35
Intraductal growth-type mucin-producing peripheral cholangiocarcinoma associated with biliary papillomatosis. ( 17240305 )
2007
36
Non-mucin-producing biliary papillomatosis diagnosed by transpapillary endoscopic curettage (with video). ( 17210153 )
2007
37
Acute pancreatitis and cholangitis caused by hemobilia from biliary papillomatosis. ( 17185104 )
2007
38
Image of the month. Biliary papillomatosis. ( 16755684 )
2006
39
Long-term survival after isolated liver transplantation for intrahepatic biliary papillomatosis. ( 16441776 )
2006
40
Molecular and virological studies on a rare case of biliary papillomatosis. ( 16821587 )
2006
41
Malignant potential of intrahepatic biliary papillomatosis: a case report and review of the literature. ( 17026772 )
2006
42
Well differentiated intrahepatic cholangiocarcinoma in the setting of biliary papillomatosis: a case report and review of the literature. ( 16341314 )
2005
43
Clinicopathologic review of 58 patients with biliary papillomatosis. ( 14770435 )
2004
44
Biliary papillomatosis: report of seven cases and review of English literature. ( 14598142 )
2003
45
Sonographic appearance of mucinous biliary papillomatosis. ( 14620899 )
2003
46
Biliary papillomatosis arising in a congenital choledochal cyst: report of a case. ( 12444445 )
2002
47
Multiple biliary papillomatosis: comparison of MR cholangiography with endoscopic retrograde cholangiography. ( 12488745 )
2002
48
EUS in multiple biliary papillomatosis. ( 11756933 )
2002
49
Malignant intrahepatic biliary papillomatosis associated with viral C cirrhosis. ( 11860318 )
2002
50
Expression of MUC1 and MUC2 and carbohydrate antigen Tn change during malignant transformation of biliary papillomatosis. ( 11422499 )
2001

Variations for Biliary Papillomatosis

Cosmic variations for Biliary Papillomatosis:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM516 KRAS biliary tract,bile duct,other,papillomatosis c.34G>T p.G12C 12:25245351-25245351 0

Expression for Biliary Papillomatosis

Search GEO for disease gene expression data for Biliary Papillomatosis.

Pathways for Biliary Papillomatosis

Pathways related to Biliary Papillomatosis according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.4 CCNA2 CDX2 CEACAM5 MUC1 MUC17 MUC2
2
Show member pathways
12.43 CDX2 HRAS KRAS MUC2 TP53
3 12.3 KRT19 KRT20 KRT7 MUC1
4 12.01 CCNA2 HRAS KRAS TP53
5
Show member pathways
11.95 HRAS KRAS TP53
6
Show member pathways
11.86 HRAS KRAS TP53
7 11.82 HRAS KRAS TP53
8
Show member pathways
11.82 MUC1 MUC17 MUC2 MUC5AC MUC6
9 11.8 HRAS KRAS TP53
10 11.78 HRAS KRAS TP53
11 11.76 HRAS KRAS TP53
12 11.76 CCNA2 HRAS KRAS TP53
13
Show member pathways
11.58 HRAS KRAS MUC1 MUC17 MUC2 MUC5AC
14 11.52 HRAS KRAS TP53
15
Show member pathways
11.52 MUC1 MUC17 MUC2 MUC5AC MUC6
16 11.45 HRAS KRAS TP53
17 11.42 HRAS KRAS TP53
18 11.09 HRAS KRAS TP53
19 10.93 HRAS KRAS
20 10.88 HRAS KRAS
21 10.64 HRAS KRAS

GO Terms for Biliary Papillomatosis

Cellular components related to Biliary Papillomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi lumen GO:0005796 9.02 MUC1 MUC17 MUC2 MUC5AC MUC6

Biological processes related to Biliary Papillomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornification GO:0070268 9.58 KRT19 KRT20 KRT7
2 Ras protein signal transduction GO:0007265 9.46 CCNA2 HRAS KRAS TP53
3 regulation of long-term neuronal synaptic plasticity GO:0048169 9.43 HRAS KRAS
4 maintenance of gastrointestinal epithelium GO:0030277 9.37 MUC2 MUC6
5 O-glycan processing GO:0016266 9.35 MUC1 MUC17 MUC2 MUC5AC MUC6
6 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.32 MUC1 TP53
7 response to isolation stress GO:0035900 9.26 HRAS KRAS
8 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.17 HRAS KRAS MUC1 MUC17 MUC2 MUC5AC

Sources for Biliary Papillomatosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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