MCID: BLR005
MIFTS: 38

Biliary Papillomatosis

Categories: Cancer diseases, Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Biliary Papillomatosis

MalaCards integrated aliases for Biliary Papillomatosis:

Name: Biliary Papillomatosis 12 15 73
Bile Duct Papillomatosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5468
NCIt 50 C65198

Summaries for Biliary Papillomatosis

Disease Ontology : 12 A biliary tract neoplasm characterized by multiple papillary tumors in the intrahepatic and/or extrahepatic biliary tree.

MalaCards based summary : Biliary Papillomatosis, also known as bile duct papillomatosis, is related to bile duct cysts and papilloma. An important gene associated with Biliary Papillomatosis is MUC2 (Mucin 2, Oligomeric Mucus/Gel-Forming), and among its related pathways/superpathways are HIV Life Cycle and Metabolism of proteins. Affiliated tissues include liver, lung and colon, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Biliary Papillomatosis

Diseases related to Biliary Papillomatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 275)
# Related Disease Score Top Affiliating Genes
1 bile duct cysts 30.7 HRAS KRAS
2 papilloma 30.3 KRT20 KRT7 TP53
3 adenocarcinoma 29.9 HRAS KRAS MUC1 TP53
4 intrahepatic cholangiocarcinoma 28.6 CDX2 KRAS KRT19 KRT20 KRT7 MUC1
5 cholangiocarcinoma 28.6 CDX2 CEACAM5 KRAS KRT19 KRT20 KRT7
6 intrahepatic biliary papillomatosis 12.4
7 extrahepatic biliary papillomatosis 12.4
8 cap polyposis 10.3 MUC2 MUC5AC
9 small intestine adenocarcinoma 10.3 MUC2 MUC6
10 filamentary keratitis 10.3 MUC1 MUC5AC
11 microcystic adenoma 10.3 MUC1 MUC6
12 chronic cholangitis 10.3 CDX2 MUC2
13 endocervical carcinoma 10.3 KRT7 MUC6
14 endosalpingiosis 10.3 KRT7 MUC1
15 parachordoma 10.3 KRT7 MUC1
16 cervical polyp 10.3 CDX2 MUC6
17 secretory meningioma 10.3 KRT7 MUC1
18 middle ear adenoma 10.3 KRT7 MUC1
19 monophasic synovial sarcoma 10.3 KRT7 MUC1
20 hepatoid adenocarcinoma 10.3 CDX2 MUC1
21 well-differentiated liposarcoma 10.3 KRT7 MUC1
22 nasal cavity cancer 10.2 CDX2 KRT7
23 ovary neuroendocrine neoplasm 10.2 CDX2 KRT7
24 epithelial predominant wilms' tumor 10.2 CDX2 KRT7
25 chordoid glioma 10.2 MUC1 TP53
26 vulvar disease 10.2 KRT7 TP53
27 female reproductive endometrioid cancer 10.2 KRT7 TP53
28 pleomorphic carcinoma 10.2 KRT7 TP53
29 vulvar intraepithelial neoplasia 10.2 KRT7 TP53
30 syringocystadenoma papilliferum 10.2 KRAS MUC1
31 esophagus adenocarcinoma 10.2 CDX2 TP53
32 alveoli adenoma 10.2 KRAS KRT7
33 hidradenoma 10.2 KRT7 MUC1
34 malignant leydig cell tumor 10.2 KRT19 KRT7
35 chondroid lipoma 10.2 KRT19 KRT7
36 corneal abscess 10.2 KRT19 KRT7
37 pulmonary blastoma 10.2 KRAS TP53
38 renal pelvis adenocarcinoma 10.2 KRT19 KRT7
39 intrahepatic bile duct adenoma 10.2 KRT19 KRT7
40 mature teratoma 10.2 KRAS TP53
41 spiradenoma 10.2 KRT7 TP53
42 rare adenocarcinoma of the breast 10.2 KRAS TP53
43 proliferating trichilemmal cyst 10.2 KRT19 KRT7
44 hyperplastic polyposis syndrome 10.2 KRAS TP53
45 mutyh-associated polyposis 10.2 KRAS TP53
46 embryoma 10.2 CDX2 KRT19
47 cholangitis 10.2
48 meningeal melanomatosis 10.2 HRAS TP53
49 spitz nevus 10.2 HRAS TP53
50 large intestine adenocarcinoma 10.2 KRT20 KRT7

Graphical network of the top 20 diseases related to Biliary Papillomatosis:



Diseases related to Biliary Papillomatosis

Symptoms & Phenotypes for Biliary Papillomatosis

GenomeRNAi Phenotypes related to Biliary Papillomatosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.47 HRAS KRAS MUC1
2 Decreased viability GR00106-A-0 9.47 KRAS
3 Decreased viability GR00221-A-1 9.47 HRAS KRAS
4 Decreased viability GR00221-A-2 9.47 HRAS KRAS
5 Decreased viability GR00221-A-3 9.47 HRAS
6 Decreased viability GR00301-A 9.47 KRAS
7 Decreased viability GR00381-A-1 9.47 KRAS
8 Decreased viability GR00402-S-2 9.47 HRAS KRAS MUC1

MGI Mouse Phenotypes related to Biliary Papillomatosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.5 CDX2 HRAS KRAS KRT19 MUC2 MUC5AC
2 neoplasm MP:0002006 9.1 CDX2 HRAS KRAS KRT19 MUC2 TP53

Drugs & Therapeutics for Biliary Papillomatosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Contrast Enhanced Ultrasound and Molecular Analysis in the Diagnosis of Pancreatic Cyst Recruiting NCT03740360

Search NIH Clinical Center for Biliary Papillomatosis

Genetic Tests for Biliary Papillomatosis

Anatomical Context for Biliary Papillomatosis

MalaCards organs/tissues related to Biliary Papillomatosis:

41
Liver, Lung, Colon, Pancreas, Thyroid, Thymus

Publications for Biliary Papillomatosis

Articles related to Biliary Papillomatosis:

(show top 50) (show all 77)
# Title Authors Year
1
Successful Orthotopic Liver Transplant for Diffuse Biliary Papillomatosis With Malignant Transformation: A Case Report With Long-Term Follow-Up. ( 29534660 )
2018
2
Caroli's disease associated with biliary papillomatosis and cholangiolithiasis. ( 29969806 )
2018
3
Tumor recurrence after liver transplantation for diffuse biliary papillomatosis in the absence of invasive carcinoma. ( 29938516 )
2018
4
Biliary papillomatosis. ( 30431667 )
2018
5
Robotic left hepatectomy and Roux-en-Y right hepatico-jejunostomy for biliary papillomatosis. ( 26845467 )
2016
6
Biliary papillomatosis with malignant transformation: A case report and review of the literature. ( 26722332 )
2015
7
Volume-reserving Surgery after Photodynamic Therapy for Biliary Papillomatosis: A Case Report. ( 26194131 )
2015
8
Recurrent cholangitis in a 65-year-old man. Biliary papillomatosis. ( 25533647 )
2015
9
Intrahepatic biliary papillomatosis associated with malignant transformation: report of two cases and review of the literature. ( 26885145 )
2015
10
Biliary papillomatosis: diagnosis with direct peroral cholangioscopy. ( 24929479 )
2014
11
Successful surgical treatment of extrahepatic biliary papillomatosis diagnosed with endoscopic retrograde cholangiopancreatography: a case report. ( 24885726 )
2014
12
Rare event of biliary papillomatosis arising in a choledochal cyst. ( 24990847 )
2014
13
Biliary papillomatosis. ( 24714176 )
2014
14
Biliary papillomatosis: correlation of radiologic findings with percutaneous transhepatic cholangioscopy. ( 24369325 )
2013
15
Biliary papillomatosis in the common bile duct. ( 23832505 )
2013
16
Extrahepatic biliary papillomatosis in a child. ( 24381830 )
2013
17
Biliary papillomatosis and new ultrasound imaging modalities. ( 22298103 )
2012
18
Multicentric biliary papillomatosis with synchronous gallbladder malignancy. ( 22803310 )
2012
19
Biliary papillomatosis in three Caucasian patients in a Western centre. ( 22154963 )
2012
20
Benign biliary papillomatosis in a patient with a choledochal cyst presenting as haemobilia: a case report. ( 22524914 )
2012
21
Biliary papillomatosis. Case report. ( 21988050 )
2011
22
Biliary papillomatosis diagnosed with mother-daughter narrow-band imaging (NBI) cholangioscopy. ( 21425023 )
2011
23
Biliary papillomatosis. ( 20879032 )
2010
24
Surgical strategy of biliary papillomatosis in Western countries. ( 19649560 )
2010
25
Multidisciplinary treatment of aggressive and rapidly progressing biliary papillomatosis. ( 20411427 )
2010
26
Mucin-producing intrahepatic biliary papillomatosis. ( 20740348 )
2010
27
Biliary papillomatosis with adenocarcinoma arising in choledochal cyst. ( 20426283 )
2009
28
Novel application of intraductal argon plasma coagulation in biliary papillomatosis (with video). ( 18656860 )
2009
29
Left hemihepatectomy and caudate lobectomy and complete extrahepatic bile duct resection using transduodenal approach for hilar cholangiocarcinoma arsing from biliary papillomatosis. ( 18521837 )
2008
30
Best cases from the AFIP: biliary papillomatosis. ( 19001658 )
2008
31
Biliary papillomatosis: analysis of 18 cases. ( 19187604 )
2008
32
Successful photodynamic therapy for biliary papillomatosis: a case report. ( 18636672 )
2008
33
Intraductal growth-type mucin-producing peripheral cholangiocarcinoma associated with biliary papillomatosis. ( 17240305 )
2007
34
Non-mucin-producing biliary papillomatosis diagnosed by transpapillary endoscopic curettage (with video). ( 17210153 )
2007
35
Acute pancreatitis and cholangitis caused by hemobilia from biliary papillomatosis. ( 17185104 )
2007
36
Image of the month. Biliary papillomatosis. ( 16755684 )
2006
37
Long-term survival after isolated liver transplantation for intrahepatic biliary papillomatosis. ( 16441776 )
2006
38
Molecular and virological studies on a rare case of biliary papillomatosis. ( 16821587 )
2006
39
Malignant potential of intrahepatic biliary papillomatosis: a case report and review of the literature. ( 17026772 )
2006
40
Well differentiated intrahepatic cholangiocarcinoma in the setting of biliary papillomatosis: a case report and review of the literature. ( 16341314 )
2005
41
Clinicopathologic review of 58 patients with biliary papillomatosis. ( 14770435 )
2004
42
Biliary papillomatosis: report of seven cases and review of English literature. ( 14598142 )
2003
43
Sonographic appearance of mucinous biliary papillomatosis. ( 14620899 )
2003
44
Biliary papillomatosis arising in a congenital choledochal cyst: report of a case. ( 12444445 )
2002
45
Multiple biliary papillomatosis: comparison of MR cholangiography with endoscopic retrograde cholangiography. ( 12488745 )
2002
46
EUS in multiple biliary papillomatosis. ( 11756933 )
2002
47
Malignant intrahepatic biliary papillomatosis associated with viral C cirrhosis. ( 11860318 )
2002
48
Expression of MUC1 and MUC2 and carbohydrate antigen Tn change during malignant transformation of biliary papillomatosis. ( 11422499 )
2001
49
Orthotopic liver transplantation for biliary papillomatosis. ( 11244169 )
2001
50
Successful liver transplantation for diffuse biliary papillomatosis. ( 11682045 )
2001

Variations for Biliary Papillomatosis

Cosmic variations for Biliary Papillomatosis:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM516 KRAS biliary tract,bile duct,other,papillomatosis c.34G>T p.G12C 12:25245351-25245351 5

Expression for Biliary Papillomatosis

Search GEO for disease gene expression data for Biliary Papillomatosis.

Pathways for Biliary Papillomatosis

Pathways related to Biliary Papillomatosis according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.51 HRAS KRAS MUC1 MUC17 MUC2 MUC5AC
2
Show member pathways
13.48 CDX2 CEACAM5 MUC1 MUC17 MUC2 MUC5AC
3
Show member pathways
12.39 CDX2 HRAS KRAS MUC2 TP53
4
Show member pathways
12.3 HRAS KRAS MUC1 TP53
5 12.28 KRT19 KRT20 KRT7 MUC1
6 12.01 HRAS KRAS TP53
7
Show member pathways
12.01 HRAS KRAS TP53
8
Show member pathways
11.97 HRAS KRAS TP53
9
Show member pathways
11.96 HRAS KRAS TP53
10
Show member pathways
11.92 MUC1 MUC17 MUC2 MUC5AC MUC6
11 11.87 HRAS KRAS TP53
12
Show member pathways
11.86 HRAS KRAS TP53
13 11.82 HRAS KRAS TP53
14 11.8 HRAS KRAS TP53
15 11.78 HRAS KRAS TP53
16 11.76 HRAS KRAS TP53
17
Show member pathways
11.72 MUC1 MUC17 MUC2 MUC5AC MUC6
18
Show member pathways
11.58 HRAS KRAS MUC1 MUC17 MUC2 MUC5AC
19 11.47 HRAS KRAS TP53
20 11.39 HRAS KRAS TP53
21
Show member pathways
11.39 MUC1 MUC17 MUC2 MUC5AC MUC6
22 11.36 HRAS KRAS TP53
23 11.07 HRAS KRAS TP53
24 10.99 HRAS KRAS
25 10.96 HRAS KRAS
26 10.88 HRAS KRAS
27 10.64 HRAS KRAS

GO Terms for Biliary Papillomatosis

Cellular components related to Biliary Papillomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi lumen GO:0005796 9.02 MUC1 MUC17 MUC2 MUC5AC MUC6

Biological processes related to Biliary Papillomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornification GO:0070268 9.54 KRT19 KRT20 KRT7
2 regulation of long-term neuronal synaptic plasticity GO:0048169 9.43 HRAS KRAS
3 maintenance of gastrointestinal epithelium GO:0030277 9.4 MUC2 MUC6
4 O-glycan processing GO:0016266 9.35 MUC1 MUC17 MUC2 MUC5AC MUC6
5 Ras protein signal transduction GO:0007265 9.33 HRAS KRAS TP53
6 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.32 MUC1 TP53
7 response to isolation stress GO:0035900 9.26 HRAS KRAS
8 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.17 HRAS KRAS MUC1 MUC17 MUC2 MUC5AC

Sources for Biliary Papillomatosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....